Details of the Researcher

PHOTO

Bin Li
Section
Advanced Research Center for Innovations in Next-Generation Medicine
Job title
Senior Assistant Professor
Degree

  • 博士（医学）（東北大学）

  • Ｍ．Ｓ．（中国吉林大学）

e-Rad No.
20566814

Research History 1

  • 2024/04 -
    Tohoku University

Professional Memberships 2

  • Japan Society of Obstetrics and Gyneology

  • Japan Society of Biochemistry and Molecular Biology

Research Interests 5

  • AMPK

  • SERM

  • ヒト子宮筋腫モデルマウス

  • 子宮筋腫

  • ELT-3細胞

Research Areas 1

  • Life sciences / Tumor biology /

Awards 1

  1. IS Good Poster Award

Papers 37

  1. Hypoxia and heme oxygenases: Oxygen sensing and regulation of expression Peer-reviewed

    Shigeki Shibahara, Feng Han, Bin Li, Kazuhisa Takeda

    ANTIOXIDANTS & REDOX SIGNALING　9　(12)　2209-2225　2007/12

    DOI： 10.1089/ars.2007.1784 　

    ISSN： 1523-0864

    eISSN： 1557-7716

  2. 子宮頸癌における血漿メタボローム解析を用いた治療効果予測バイオマーカーの探索

    萩原 達也, 島田 宗昭, 菱沼 英史, 李 賓, 久木元 詩央香, 栃木 実佳子, 清水 孝規, 宮原 周子, 吉泉 絵理, 湊 純子, 渋谷 祐介, 橋本 千明, 石橋 ますみ, 重田 昌吾, 徳永 英樹, 小柴 生造, 齋藤 昌利, 八重樫 伸生

    日本婦人科腫瘍学会学術講演会プログラム・抄録集　66回　260-260　2024/07

    Publisher: (公社)日本婦人科腫瘍学会

  3. 血漿メタボローム解析を用いた子宮頸癌代謝プロファイリングの再検証

    太田 真理子, 島田 宗昭, 菱沼 英史, 李 賓, 久木元 詩央香, 萩原 達也, 栃木 実佳子, 清水 孝規, 宮原 周子, 吉泉 絵理, 湊 純子, 渋谷 祐介, 橋本 千明, 石橋 ますみ, 重田 昌吾, 徳永 英樹, 小柴 生造, 八重樫 伸生

    日本婦人科腫瘍学会学術講演会プログラム・抄録集　66回　261-261　2024/07

    Publisher: (公社)日本婦人科腫瘍学会

  4. 卵巣癌における口腔内メタゲノム解析によるバイオマーカーの探索

    橋本 千明, 島田 宗昭, 齋藤 さかえ, 玉原 亨, 李 賓, 菱沼 英史, 青木 裕一, 渋谷 祐介, 久木元 詩央香, 栃木 実佳子, 萩原 達也, 清水 孝規, 工藤 敬, 湊 純子, 石橋 ますみ, 重田 昌吾, 徳永 英樹, 清水 律子, 八重樫 伸生

    日本婦人科腫瘍学会学術講演会プログラム・抄録集　66回　275-275　2024/07

    Publisher: (公社)日本婦人科腫瘍学会

  5. Sequential Sampling of the Gastrointestinal Tract to Characterize the Entire Digestive Microbiome in Japanese Subjects

    Kota Ishizawa, Toru Tamahara, Suguo Suzuki, Yutaka Hatayama, Bin Li, Michiaki Abe, Yuichi Aoki, Ryutaro Arita, Natsumi Saito, Minoru Ohsawa, Soichiro Kaneko, Rie Ono, Shin Takayama, Muneaki Shimada, Kazuki Kumada, Tomoyuki Koike, Atsushi Masamune, Ko Onodera, Tadashi Ishii, Ritsuko Shimizu, Takeshi Kanno

    Microorganisms　12　(7)　1324-1324　2024/06/28

    Publisher: MDPI AG

    DOI： 10.3390/microorganisms12071324 　

    eISSN： 2076-2607

    More details Close

    The gastrointestinal (GI) tract harbors trillions of microorganisms known to influence human health and disease, and next-generation sequencing (NGS) now enables the in-depth analysis of their diversity and functions. Although a significant amount of research has been conducted on the GI microbiome, comprehensive metagenomic datasets covering the entire tract are scarce due to cost and technical challenges. Despite the widespread use of fecal samples, integrated datasets encompassing the entire digestive process, beginning at the mouth and ending with feces, are lacking. With this study, we aimed to fill this gap by analyzing the complete metagenome of the GI tract, providing insights into the dynamics of the microbiota and potential therapeutic avenues. In this study, we delved into the complex world of the GI microbiota, which we examined in five healthy Japanese subjects. While samples from the whole GI flora and fecal samples provided sufficient bacteria, samples obtained from the stomach and duodenum posed a challenge. Using a principal coordinate analysis (PCoA), clear clustering patterns were identified; these revealed significant diversity in the duodenum. Although this study was limited by its small sample size, the flora in the overall GI tract showed unwavering consistency, while the duodenum exhibited unprecedented phylogenetic diversity. A visual heat map illustrates the discrepancy in abundance, with Fusobacteria and Bacilli dominating the upper GI tract and Clostridia and Bacteroidia dominating the fecal samples. Negativicutes and Actinobacteria were found throughout the digestive tract. This study demonstrates that it is possible to continuously collect microbiome samples throughout the human digestive tract. These findings not only shed light on the complexity of GI microbiota but also provide a basis for future research.

  6. Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling Peer-reviewed

    Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Yoshiko Shima, Bin Li, Ikuko N. Motoike, Yusuke Shibuya, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, Daisuke Saigusa, Kengo Kinoshita, Seizo Koshiba, Nobuo Yaegashi

    Cancer & Metabolism　11　(1)　11-16　2023/10/11

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40170-023-00317-z 　

    eISSN： 2049-3002

    More details Close

    Abstract Background Endometrial cancer (EMC) is the most common female genital tract malignancy with an increasing prevalence in many countries including Japan, a fact that renders early detection and treatment necessary to protect health and fertility. Although early detection and treatment are necessary to further improve the prognosis of women with endometrial cancer, biomarkers that accurately reflect the pathophysiology of EMC patients are still unclear. Therefore, it is clinically critical to identify biomarkers to assess diagnosis and treatment efficacy to facilitate appropriate treatment and development of new therapies for EMC. Methods In this study, wide-targeted plasma metabolome analysis was performed to identify biomarkers for EMC diagnosis and the prediction of treatment responses. The absolute quantification of 628 metabolites in plasma samples from 142 patients with EMC was performed using ultra-high-performance liquid chromatography with tandem mass spectrometry. Results The concentrations of 111 metabolites increased significantly, while the concentrations of 148 metabolites decreased significantly in patients with EMC compared to healthy controls. Specifically, LysoPC and TGs, including unsaturated fatty acids, were reduced in patients with stage IA EMC compared to healthy controls, indicating that these metabolic profiles could be used as early diagnostic markers of EMC. In contrast, blood levels of amino acids such as histidine and tryptophan decreased as the risk of recurrence increased and the stages of EMC advanced. Furthermore, a marked increase in total TG and a decrease in specific TGs and free fatty acids including polyunsaturated fatty acids levels were observed in patients with EMC. These results suggest that the polyunsaturated fatty acids in patients with EMC are crucial for disease progression. Conclusions Our data identified specific metabolite profiles that reflect the pathogenesis of EMC and showed that these metabolites correlate with the risk of recurrence and disease stage. Analysis of changes in plasma metabolite profiles could be applied for the early diagnosis and monitoring of the course of treatment of EMC patients.

  7. Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide‐targeted metabolomics International-journal Peer-reviewed

    Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Bin Li, Ikuko N. Motoike, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, Daisuke Saigusa, Kengo Kinoshita, Seizo Koshiba, Nobuo Yaegashi

    Journal of Obstetrics and Gynaecology Research　49　(8)　2109-2117　2023/06/09

    Publisher: Wiley

    DOI： 10.1111/jog.15709 　

    ISSN： 1341-8076

    eISSN： 1447-0756

    More details Close

    AIM: Uterine cervical cancer (UCC) is the fourth most common cancer in women, responsible for more than 300 000 deaths worldwide. Its early detection, by cervical cytology, and prevention, by vaccinating against human papilloma virus, greatly contribute to reducing cervical cancer mortality in women. However, penetration of the effective prevention of UCC in Japan remains low. Plasma metabolome analysis is widely used for biomarker discovery and the identification of cancer-specific metabolic pathways. Here, we aimed to identify predictive biomarkers for the diagnosis and radiation sensitivity of UCC using wide-targeted plasma metabolomics. METHODS: We analyzed 628 metabolites in plasma samples obtained from 45 patients with UCC using ultra-high-performance liquid chromatography with tandem mass spectrometry. RESULTS: The levels of 47 metabolites were significantly increased and those of 75 metabolites were significantly decreased in patients with UCC relative to healthy controls. Increased levels of arginine and ceramides, and decreased levels of tryptophan, ornithine, glycosylceramides, lysophosphatidylcholine, and phosphatidylcholine were characteristic of patients with UCC. Comparison of metabolite profiles in groups susceptible and non-susceptible to radiation therapy, a treatment for UCC, revealed marked variations in polyunsaturated fatty acid, nucleic acid, and arginine metabolism in the group not susceptible to treatment. CONCLUSIONS: Our findings suggest that the metabolite profile of patients with UCC may be an important indicator for distinguishing these patients from healthy cohorts, and may also be useful for predicting sensitivity to radiotherapy.

  8. Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125 Peer-reviewed

    Takamichi Minato, Shin Ito, Bin Li, Haruna Fujimori, Mai Mochizuki, Kazunori Yamaguchi, Keiichi Tamai, Muneaki Shimada, Hideki Tokunaga, Shogo Shigeta, Ikuro Sato, Hiroshi Shima, Hidekazu Yamada, Nobuo Yaegashi, Jun Yasuda

    Gynecologic Oncology Reports　38　100847-100847　2021/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.gore.2021.100847 　

    ISSN： 2352-5789

  9. Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer. International-journal

    Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Daisuke Saigusa, Bin Li, Kei Kudo, Keita Tsuji, Shogo Shigeta, Hideki Tokunaga, Kazuki Kumada, Keigo Komine, Hidekazu Shirota, Yuichi Aoki, Ikuko N Motoike, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto, Seizo Koshiba, Nobuo Yaegashi

    Toxins　13　(7)　2021/06/30

    DOI： 10.3390/toxins13070461 　

    More details Close

    Epithelial ovarian cancer (EOC) is a fatal gynecologic cancer, and its poor prognosis is mainly due to delayed diagnosis. Therefore, biomarker identification and prognosis prediction are crucial in EOC. Altered cell metabolism is a characteristic feature of cancers, and metabolomics reflects an individual's current phenotype. In particular, plasma metabolome analyses can be useful for biomarker identification. In this study, we analyzed 624 metabolites, including uremic toxins (UTx) in plasma derived from 80 patients with EOC using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Compared with the healthy control, we detected 77 significantly increased metabolites and 114 significantly decreased metabolites in EOC patients. Especially, decreased concentrations of lysophosphatidylcholines and phosphatidylcholines and increased concentrations of triglycerides were observed, indicating a metabolic profile characteristic of EOC patients. After calculating the parameters of each metabolic index, we found that higher ratios of kynurenine to tryptophan correlates with worse prognosis in EOC patients. Kynurenine, one of the UTx, can affect the prognosis of EOC. Our results demonstrated that plasma metabolome analysis is useful not only for the diagnosis of EOC, but also for predicting prognosis with the variation of UTx and evaluating response to chemotherapy.

  10. The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer Peer-reviewed

    Hodaka Tayama, Hideaki Karasawa, Akihiro Yamamura, Yasunobu Okamura, Fumiki Katsuoka, Hideyuki Suzuki, Taiki Kajiwara, Minoru Kobayashi, Yuuri Hatsuzawa, Masahiro Shiihara, Li Bin, Md, Yeashin Gazi, Mizuki Sato, Kazuki Kumada, Shigehiro Ito, Muneaki Shimada, Toru Furukawa, Takashi Kamei, Shinobu Ohnuma, Michiaki Unno

    Biochem Biophys Res Commun .　30　(560)　59-65　2021/06

  11. Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines Peer-reviewed

    Noriko Ishida, Yuichi Aoki, Fumiki Katsuoka, Ichiko Nishijima, Takahiro Nobukuni, Hayato Anzawa, Li Bin, Miyuki Tsuda, Kazuki Kumada, Hisaaki Kudo, Takahiro Terakawa, Akihito Otsuki, Kengo Kinoshita, Riu Yamashita, Naoko Minegishi, Masayuki Yamamoto

    Free Radic Biol Med .　161　71-83　2020/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.freeradbiomed.2020.09.023 　

    ISSN： 0891-5849

  12. Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing Peer-reviewed

    Yusuke Shibuya, Hideki Tokunaga, Sakae Saito, Kazurou Shimokawa, Fumiki Katsuoka, Li Bin, Kaname Kojima, Masao Nagasaki, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda

    GENES CHROMOSOMES & CANCER　57　(2)　51-60　2018/02

    DOI： 10.1002/gcc.22507 　

    ISSN： 1045-2257

    eISSN： 1098-2264

  13. 17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer. Peer-reviewed

    Hashimoto C, Miki Y, Tanaka S, Takagi K, Fue M, Doe Z, Li B, Yaegashi N, Suzuki T, Ito K

    Int J Mol Sci.　19　E1139　2018

  14. SS5020の阻害効果の研究 異種移植マウスモデルにおける子宮平滑筋腫の選択的エストロゲン受容体修飾物質(Investigate the Inhibitory Effect of SS5020-A Selective Estrogen Receptor Modulator on Uterine Leiomyomas in an Xenograft Mouse Model)

    Li Bin, Takeda Takashi, Tsuiji Kenji, Yaegashi Nobuo

    日本産科婦人科学会雑誌　69　(2)　561-561　2017/02

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  15. 新規選択的エストロゲン受容体モジュレーターによる子宮筋腫治療薬開発

    李 賓

    産科と婦人科　83　1342-1343　2016/11

  16. Investigate the Inhibitory Effect of SS5020-A Selective Estrogen Receptor Modulator on Uterine Leiomyomas. Peer-reviewed

    Bin Li, Takashi Takeda, Kenji Tsuiji, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES　23　332A-332A　2016/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  17. Improvement of Bioavailability and Apoptosis Potential of Curcumin in Combination With Epigallocatechin-3-Gallate in Leiomyosarcoma Cells Peer-reviewed

    Li Bin, Takeda Takashi, Tsuiji Kenji, Tadakawa Mari, Kondo Akiko, Yaegashi Nobuo

    REPRODUCTIVE SCIENCES　22　119A　2015/03

    ISSN： 1933-7191

  18. Inhibitory Effects of Curcumin and Nanocurcumin on Human Uterine Leiomyoma Xenograft Model In Vivo. Peer-reviewed

    Tsuiji Kenji, Takeda Takashi, Li Bin, Tadakawa Mari, Yaegashi Nobuo

    REPRODUCTIVE SCIENCES　22　306A　2015/03

    ISSN： 1933-7191

  19. 平滑筋肉腫細胞におけるepigallocatechin-3-gallateを併用したクルクミンの生体利用性とアポトーシス誘導能の改善(Improvement of bioavailability and apoptosis potential of curcumin in combination with epigallocatechin-3-gallate in leiomyosarcoma cells)

    Li Bin, Takeda Takashi, Tsuiji Kenji, Tadakawa Mari, Kondo Akiko, Yaegashi Nobuo

    日本産科婦人科学会雑誌　67　(2)　1022-1022　2015/02

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  20. The role of 5 alpha-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma Peer-reviewed

    Sota Tanaka, Yasuhiro Miki, Chiaki Hashimoto, Kiyoshi Takagi, Zhulanqiqige Doe, Bin Li, Nobuo Yaegashi, Takashi Suzuki, Kiyoshi Ito

    MOLECULAR AND CELLULAR ENDOCRINOLOGY　401　(C)　56-64　2015/02

    DOI： 10.1016/j.mce.2014.11.022 　

    ISSN： 0303-7207

  21. Proliferative effect of Hachimijiogan, a Japanese herbal medicine, in C2C12 skeletal muscle cells Peer-reviewed

    Takashi Takeda, Kenji Tsuiji, Bin Li, Mari Tadakawa, Nobuo Yaegashi

    CLINICAL INTERVENTIONS IN AGING　10　445-451　2015

    DOI： 10.2147/CIA.S75945 　

    ISSN： 1178-1998

  22. The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1 alpha signaling pathway in ELT-3 cells Peer-reviewed

    Mad Tadakawa, Takashi Takeda, Bin Li, Kenji Tsuiji, Nobuo Yaegashi

    MOLECULAR AND CELLULAR ENDOCRINOLOGY　399　(C)　1-8　2015/01

    DOI： 10.1016/j.mce.2014.08.012 　

    ISSN： 0303-7207

  23. Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression Peer-reviewed

    Tze Fang Wong, Takashi Takeda, Bin Li, Kenji Tsuiji, Akiko Kondo, Mari Tadakawa, Satoru Nagase, Nobuo Yaegashi

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY　19　(2)　354-363　2014/04

    DOI： 10.1007/s10147-013-0563-4 　

    ISSN： 1341-9625

    eISSN： 1437-7772

  24. Curcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma Cells Peer-reviewed

    Bin Li, Takashi Takeda, Kenji Tsuiji, Tze Fang Wong, Mari Tadakawa, Akiko Kondo, Satoru Nagase, Nobuo Yaegashi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER　23　(5)　803-808　2013/06

    DOI： 10.1097/IGC.0b013e31828c9581 　

    ISSN： 1048-891X

    eISSN： 1525-1438

  25. Epigallocatechin-3-gallate potentiates curcumin's ability to suppress uterine leiomyosarcoma cell growth and induce apoptosis Peer-reviewed

    Akiko Kondo, Takashi Takeda, Bin Li, Kenji Tsuiji, Mari Kitamura, Tze Fang Wong, Nobuo Yaegashi

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY　18　(3)　380-388　2013/06

    DOI： 10.1007/s10147-012-0387-7 　

    ISSN： 1341-9625

  26. The antidiabetic drug metformin inhibits uterine leiomyoma cell proliferation via an AMP-activated protein kinase signaling pathway Peer-reviewed

    Bin Li, Takashi Takeda, Kenji Tsuiji, Akiko Kondo, Mari Kitamura, Tze Fang Wong, Nobuo Yaegashi

    Gynecological Endocrinology　29　(1)　87-90　2013/01

    DOI： 10.3109/09513590.2012.706668 　

    ISSN： 0951-3590 1473-0766

  27. Coordinated Expression of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase 4 and Heme Oxygenase 2: Evidence for a Regulatory Link between Glycolysis and Heme Catabolism Peer-reviewed

    Bin Li, Kazuhisa Takeda, Kazunobu Ishikawa, Miki Yoshizawa, Michihiko Sato, Shigeki Shibahara, Kazumichi Furuyama

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　228　(1)　27-41　2012/09

    DOI： 10.1620/tjem.228.27 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  28. Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition Peer-reviewed

    Tze Fang Wong, Takashi Takeda, Bin Li, Kenji Tsuiji, Mari Kitamura, Akiko Kondo, Nobuo Yaegashi

    GYNECOLOGIC ONCOLOGY　122　(1)　141-148　2011/07

    DOI： 10.1016/j.ygyno.2011.03.001 　

    ISSN： 0090-8258

  29. Inhibitory effect of curcumin on uterine leiomyoma cell proliferation Peer-reviewed

    Kenji Tsuiji, Takashi Takeda, Bin Li, Atsuko Wakabayashi, Akiko Kondo, Tadashi Kimura, Nobuo Yaegashi

    GYNECOLOGICAL ENDOCRINOLOGY　27　(7)　512-517　2011/07

    DOI： 10.3109/09513590.2010.507287 　

    ISSN： 0951-3590

  30. 婦人科癌治療患者における漢方治療に対する意識調査と不安状態に関する検討 Peer-reviewed

    武田 卓, 吉永 浩介, 伊藤 潔, 築地 謙治, 李 賓, 山口 拓洋, 八重樫 伸生

    産婦人科 漢方研究のあゆみ　28　35-39　2011

  31. Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells Peer-reviewed

    Atsuko Wakabayashi, Takashi Takeda, Kenji Tsuiji, Bin Li, Masahiro Sakata, Ken-ichirou Morishige, Nobuo Yaegashi, Tadashi Kimura

    GYNECOLOGICAL ENDOCRINOLOGY　27　(1)　33-38　2011/01

    DOI： 10.3109/09513590.2010.487605 　

    ISSN： 0951-3590

  32. Establishment of a Novel Xenograft Model for Human Uterine Leiomyoma in Immunodeficient Mice Peer-reviewed

    Kenji Tsuiji, Takashi Takeda, Bin Li, Akiko Kondo, Mamoru Ito, Nobuo Yaegashi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　222　(1)　55-61　2010/09

    DOI： 10.1620/tjem.222.55 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  33. Aldosterone stimulates the proliferation of uterine leiomyoma cells Peer-reviewed

    Aki Isobe, Takashi Takeda, Atsuko Wakabayashi, Kenji Tsuiji, Bin Li, Masahiro Sakata, Nobuo Yaegashi, Tadashi Kimura

    GYNECOLOGICAL ENDOCRINOLOGY　26　(5)　372-377　2010/05

    DOI： 10.3109/09513590903511521 　

    ISSN： 0951-3590

  34. Prostaglandin D(2) induces heme oxygenase-1 mRNA expression through the DP2 receptor Peer-reviewed

    Soisungwan Satarug, Raewadee Wisedpanichkij, Kazuhisa Takeda, Bin Li, Kesara Na-Bangchang, Michael R. Moore, Shigeki Shibahara

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　377　(3)　878-883　2008/12

    DOI： 10.1016/j.bbrc.2008.10.094 　

    ISSN： 0006-291X

  35. Prevention of cadmium accumulation in retinal pigment epithelium with manganese and zinc Peer-reviewed

    Soisungwan Satarug, Mihoko Kikuchi, Raewadee Wisedpanichkij, Bin Li, Kazuhisa Takeda, Kesara Na-Bangchang, Michael R. Moore, Kenji Hirayama, Shigeki Shibahara

    EXPERIMENTAL EYE RESEARCH　87　(6)　587-593　2008/12

    DOI： 10.1016/j.exer.2008.09.014 　

    ISSN： 0014-4835

  36. A Prolyl-hydroxylase Inhibitor, Ethyl-3,4-dihydroxybenzoate, Induces Haem Oxygenase-1 Expression in Human Cells Through a Mechanism Independent of Hypoxia-inducible Factor-1 alpha Peer-reviewed

    Bin Li, Kazuhisa Takeda, Satoru Yokoyamay, Shigeki Shibahara

    JOURNAL OF BIOCHEMISTRY　144　(5)　643-654　2008/11

    DOI： 10.1093/jb/mvn115 　

    ISSN： 0021-924X

  37. Prostaglandin D-2 induces heme oxygenase-1 in human retinal pigment epithelial cells Peer-reviewed

    Jiraporn Kuesap, Bin Li, Soisungwan Satarug, Kazuhisa Takeda, Ikuko Numata, Kesara Na-Bangchang, Shigeki Shibahara

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　367　(2)　413-419　2008/03

    DOI： 10.1016/j.bbrc.2007.12.148 　

    ISSN： 0006-291X

Show all ︎Show first 5

Misc. 30

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    萩原達也, 島田宗昭, 菱沼英史, 李賓, 久木元詩央香, 橋本栄文, 遠藤俊, 清水孝規, 湊純子, 渋谷祐介, 石橋ますみ, 橋本千明, 重田昌吾, 徳永英樹, 八重樫伸生

    日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web)　65th　2023

  2. 子宮体癌における血漿メタボローム解析によるバイオマーカーの探索

    辻圭太, 島田宗昭, 菱沼英史, 重田昌吾, 李賓, 宮原周子, 土岐麻実, 工藤敬, 徳永英樹, 小柴生造, 木下賢吾, 山本雅之, 八重樫伸生

    日本婦人科腫瘍学会雑誌　39　(1)　2021

    ISSN： 1347-8559

  3. がん代謝を標的とした卵巣癌におけるバイオマーカーの探索

    工藤敬, 島田宗昭, 菱沼英史, 重田昌吾, 李賓, 宮原周子, 土岐麻実, 辻圭太, 徳永英樹, 小柴生造, 木下賢吾, 山本雅之, 八重樫伸生

    日本婦人科腫瘍学会雑誌　39　(1)　2021

    ISSN： 1347-8559

  4. Identification of Somatic Genetic Alterations in Ovarian Clear Cell Carcinoma with Next Generation Sequencing.

    Yusuke Shibuya, Hideki Tokunaga, Bin Li, Jun Yasuda, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES　25　92A-92A　2018/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  5. 卵巣明細胞癌における次世代配列分析による体細胞遺伝子変異の同定(Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing)

    Shibuya Yusuke, Tokunaga Hideki, Li Bin, Yaegashi Nobuo

    日本産科婦人科学会雑誌　70　(2)　508-508　2018/02

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  6. 次世代シーケンシングによる卵巣明細胞癌における体細胞遺伝子変化の同定(Identification of somatic genetic alterations in ovarian clear cell carcinomas with next generation sequencing)

    Shibuya Yusuke, Tokunaga Hideki, Li Bin, Yaegashi Nobuo

    The Journal of Obstetrics and Gynaecology Research　43　(12)　1935-1935　2017/12

    Publisher: John Wiley & Sons Australia, Ltd

    ISSN： 1341-8076

    eISSN： 1447-0756

  7. 卵巣明細胞がんを引き起こす遺伝子変異の発見(Discovery of gene alterations causing ovarian clear cell carcinoma)

    Shibuya Yusuke, Tokunaga Hideki, Saito Sakae, Kojima Kaname, Li Bin, Nagasaki Masao, Yasuda Jun, Yaegashi Nobuo

    日本婦人科腫瘍学会雑誌　35　(3)　566-566　2017/06

    Publisher: (公社)日本婦人科腫瘍学会

    ISSN： 1347-8559

  8. Identification of Somatic Genetic Alterations in Ovarian Clear Cell Carcinomas with Next Generation Sequencing.

    Yusuke Shibuya, Sakae Saito, Kaname Kojima, Bin Li, Hideki Tokunaga, Masao Nagasaki, Jun Yasuda, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES　24　268A-268A　2017/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  9. The 17 beta-Hydroxysteroid Dehydrogenase Type 2 Expression Induced by the Androgen Signal in Endometrial Cancer.

    Chiaki Hashimoto, Yasuhiro Miki, Sota Tanaka, Kiyoshi Takagi, Misaki Fue, Zhulanqiqige Doe, Bin Li, Nobuo Yaegashi, Takashi Suzuki, Kiyoshi Ito

    REPRODUCTIVE SCIENCES　24　202A-202A　2017/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  10. 次世代シークエンシングを用いた卵巣明細胞癌における体細胞遺伝的変化の同定(Identification of somatic genetic alterations in ovarian clear cell carcinomas with next generation sequencing)

    Shibuya Yusuke, Tokunaga Hideki, Li Bin, Yaegashi Nobuo

    日本産科婦人科学会雑誌　69　(2)　552-552　2017/02

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  11. 次世代シークエンサーを用いた卵巣明細胞腺癌の遺伝子変異の探索

    渋谷 祐介, 齋藤 さかえ, 小島 要, 李 賓, 徳永 英樹, 長崎 正朗, 安田 純, 八重樫 伸生

    日本癌学会総会記事　75回　P-1369　2016/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  12. 卵巣明細胞腺癌を引き起こす遺伝子変異の発見(Discovery of gene alterations causing ovarian clear cell carcinoma)

    渋谷 祐介, 徳永 英樹, 安田 純, 長崎 正朗, 斎藤 さかえ, 小島 要, 李 賓, 八重樫 伸生

    日本婦人科腫瘍学会雑誌　34　(3)　452-452　2016/06

    Publisher: (公社)日本婦人科腫瘍学会

    ISSN： 1347-8559

  13. 卵巣明細胞腺癌の原因遺伝子を探る

    渋谷 祐介, 徳永 英樹, 李 賓, 安田 純, 八重樫 伸生

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[1P1049]-[1P1049]　2015/12

    Publisher: (公社)日本生化学会

  14. ISP-8-2 Improvement of bioavailability and apoptosis potential of curcumin in combination with epigallocatechin-3-gallate in leiomyosarcoma cells(Group 8 Oncology 8,IS Poster,International Session) :

    Li Bin, Takeda Takashi, Tsuji Kenji, Tadakawa Mari, Kondo Akiko, Yaegashi Nobuo

    67　(2)　1022-1022　2015

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  15. P1-6-3 類内膜型子宮内膜腺癌においてアンドロゲンはどのような作用を持つか? : アンドロゲン合成酵素5αリダクターゼ1を中心とした検討(Group6 子宮体部腫瘍 基礎3,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    田中 創太, 橋本 千明, 李 賓, 伊藤 潔, 八重樫 伸生

    日本産科婦人科學會雜誌　67　(2)　546-546　2015

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  16. NW-21-3 糖尿病治療薬メトホルミンによる子宮筋腫抑制効果 : ヒト子宮筋腫モデルマウスを用いたin vivoでの検討(ミニワークショップ21 良性腫瘍,その他,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    築地 謙治, 武田 卓, 李 賓, 只川 真理, 八重樫 伸生

    日本産科婦人科學會雜誌　67　(2)　533-533　2015

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  17. 新規ヒト子宮筋腫モデルマウスを用いた味噌経口摂取による子宮筋腫増殖抑制効果についての検討

    武田 卓, 築地 謙治, Li Bin

    中央味噌研究所研究報告　34　61-64　2014/03

  18. ISP-8-1 The anti-diabetic drug metformin inhibits angiogenesis through HIF-1α/VEGF pathway in uterine leiomyoma in vitro(Group 8 Oncology 8,IS Poster,International Session) :

    Tadakawa Mari, Takeda Takashi, Li Bin, Tsuiji Kenji, Yaegashi Nobuo

    66　(2)　940-940　2014

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  19. MW-15-2 天然型クルクミンおよびナノクルクミンによる子宮筋腫抑制効果 : ヒト子宮筋腫モデルマウスを用いたin vivoでの検討(ミニワークショップ15 子宮筋腫・基礎と臨床,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)

    築地 謙治, 武田 卓, 李 賓, 只川 真理, 八重樫 伸生

    日本産科婦人科學會雜誌　66　(2)　2014

  20. K3-4-4 ターメリック・ウコン中の有効成分クルクミンによる子宮平滑筋肉腫細胞増殖抑制効果 : オートファジーおよびアポトーシス誘導からの検討(高得点演題16 婦人科腫瘍学5,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

    李 賓, 武田 卓, 築地 謙治, 黄 志芳, 北村 真理, 近藤 亜希子, 八重樫 伸生

    日本産科婦人科學會雜誌　65　(2)　855-855　2013

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  21. K2-1-1 プロゲスチンの子宮筋腫増殖への影響 : ヒト子宮筋腫モデルマウスを用いたin vivo での検討(高得点演題6 女性医学,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

    築地 謙治, 武田 卓, 李 賓, 北村 真理, 八重樫 伸生

    日本産科婦人科學會雜誌　65　(2)　2013

  22. Antiproliferative effect of Miso on uterine leiomyoma cells in vitro and in vivo

    33　(33)　171-174　2012/03

    Publisher: 中央味噌研究所

    ISSN： 0289-8942

  23. P1-16-3 天然物ターメリック・ウコン中の有効物質クルクミンによる子宮筋腫治療薬開発 : ヒト子宮筋腫モデルマウスを用いたin vivoでの検討(Group16 良性疾患基礎・治療1,一般演題,第64回日本産科婦人科学会学術講演会)

    築地 謙治, 武田 卓, 李 賓, 近藤 亜希子, 北村 真理, 黄 志芳, 八重樫 伸生

    日本産科婦人科學會雜誌　64　(2)　2012

  24. ウコン中のクルクミンによる子宮平滑筋肉腫細胞増殖抑制効果~mTORに対する分子標的療法の可能性

    黄志芳, 武田卓, 李賓, 築地謙治, 近藤亜希子, 北村真理, 八重樫伸生

    日本婦人科腫よう学会雑誌　29　(3)　582-582　2011/06

    Publisher: (公社)日本婦人科腫瘍学会

    ISSN： 1347-8559

  25. メトホルミンによる子宮筋腫細胞増殖抑制効果解析

    北村真理, リ ビン, 築地謙治, ウォン ツーファン, 近藤亜希子, 武田卓, 八重樫伸生

    日本内分泌学会雑誌 87(1) 389 2011年4月　87　(1)　389-389　2011/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  26. Antiproliferative effect of miso on uterine leiomyoma cells in vitro and in vivo

    Report of Central Miso Research Institute.　32　(32)　55-58　2011/03

    Publisher: 中央味噌研究所

    ISSN： 0289-8942

  27. P2-31-7 メトホルミンによる子宮筋腫細胞増殖抑制効果 : 子宮筋腫モデル細胞株・ヒト子宮筋腫モデルマウスを用いた検討(Group133 良性腫瘍・手術・基礎,一般演題,第63回日本産科婦人科学会学術講演会)

    李 賓, 武田 卓, 築地 謙治, 近藤 亜希子, 黄 志芳, 八重樫 伸生

    日本産科婦人科學會雜誌　63　(2)　899-899　2011

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  28. P2-14-12 ターメリック・ウコン中の有効成分クルクミンによる子宮平滑筋肉腫細胞増殖抑制効果 : mTORに対する分子標的療法の可能性(Group97 子宮体部悪性腫瘍・基礎1,一般演題,第63回日本産科婦人科学会学術講演会)

    黄 志芳, 武田 卓, 李 賓, 築地 謙治, 近藤 亜希子, 八重樫 伸生

    日本産科婦人科學會雜誌　63　(2)　2011

  29. P2-31-5 超免疫不全マウスを用いた新規ヒト子宮筋腫移植モデルマウスの確立(Group133 良性腫瘍・手術・基礎,一般演題,第63回日本産科婦人科学会学術講演会)

    築地 謙治, 武田 卓, 李 賓, 黄 志芳, 近藤 亜希子, 八重樫 伸生

    日本産科婦人科學會雜誌　63　(2)　2011

  30. P2-136 ターメリック・ウコン中の有効成分であるクルクミンによる子宮筋腫細胞増殖抑制効果(Group60 子宮筋腫・内膜症4,一般演題,第62回日本産科婦人科学会学術講演会)

    築地 謙治, 武田 卓, 李 賓, 近藤 亜希子, 若林 敦子, 木村 正, 八重樫 伸生

    日本産科婦人科學會雜誌　62　(2)　510-510　2010

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

Show all ︎Show first 5

Presentations 11

  1. Establishment and management a clinical biobank

    Li Bin

    2023/11/28

  2. Establishment and management a clinical biobank

    Li Bin

    2022/12/27

  3. Clinical biobank

    Li Bin

    2022/02/25

  4. Clinical Biobank in INGEM International-presentation

    Li Bin

    Collaborative Seminar by Tohoku University and CEA, France Toward the Next Generation Medicine　2018/10

  5. Investigate the Inhibitory Effect of SS5020-A Selective Estrogen Receptor Modulator on UterineLeiomyomas International-presentation

    Li Bin

    63rd Society for Reproductive Investigation　2016/03

  6. Improvement of bioavailability and apoptosis potential of curcumin in combination with epigallocatechin-3-gallate in leiomyosarcoma cells International-presentation

    Li Bin

    62nd Society for Reproductive Investigation　2015

  7. Comparison between Chinese gynecological cancer-care and Japanese gynecological cancer-care Invited

    Li Bin

    International symposium of PHRDC (Promotion Plan for the Platform of Human Resource Development for Cancer) 2014 in Iwate　2014

  8. Curcumin induces cross-regulation between autophagy and apoptosis in uterine leiomyosarcoma cells

    Li Bin

    65th JSOG (Japan Society of Obstetrics and Gynecology) Annual Meeting in Hokaido　2013

  9. The antidiabetic drug metformin inhibits uterine leiomyoma cell proliferation via an AMP-activated protein kinase signaling pathway.

    Li Bin

    63rd JSOG (Japan Society of Obstetrics and Gynecology) Annual Meeting in Osaka, 2011　2011

  10. Prostaglandin D2 as an endogenous inducer of heme oxygenase-1 expression in human retinal pigment epithelial cells.

    Li Bin

    BMB2008 Biochemistry and Molecular Biology Annual Meeting in Kobe, 2008　2008

  11. A prolyl-hydroxylase inhibitor, ethyl-3, 4-dihydroxybenzoate, induces hemeoxygenase-1 expression by a hypoxia inducible factor-1a independent mechanism in human retinal pigment epithelial cells.

    Li Bin

    BMB2007 Biochemistry and Molecular Biology Annual Meeting in Yokohama, 2007　2007

Show all Show first 5

Industrial Property Rights 1

  1. 子宮筋腫細胞増殖抑制剤

    武田 卓, 八重樫 伸生, 李 賓

    Property Type: Patent

Research Projects 3

  1. 新規選択的エストロゲン受容体モジュレーターによる子宮筋腫治療薬開発 Competitive

    李 賓

    Offer Organization: 文部科学省および日本学術振興会

    System: 科学研究費助成事業

    2013 - 2016

  2. Uterine leiomyoma and AMPK/mTOR signal transduction pathway- a new therapeutic strategy.

    TAKEDA Takashi, TSUIJI Kenji, LI Bin

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2011 - 2013

    More details Close

    Metformin is an anti-diabetic drug that is used all over the world. We have proved its anti-tumor effect and anti-angiogenic effect through suppression of the mammalian target of rapamycin (mTOR) pathway.

  3. 子宮筋腫細胞増殖・線維化における、低酸素細胞内シグナル伝達機構解析 Competitive

    李 賓

    Offer Organization: （財）日中医学協会

    System: （財）日中医学協会在留中国人研究者助成

    2010 - 2011