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Yu Mori

Section

Graduate School of Medicine

Job title

Senior Assistant Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/yu-mori

J-GLOBAL ID

201801020002629746

Research History 3

2021/04 - Present

Tohoku University　Graduate School of Medicine　Assistant Professor
2013/04 - 2020/03

Tohoku University　Graduate School of Medicine　Assistant professor
2010/04 - 2011/03

University of Connecticut博士研究員

Education 2

Tohoku University　Graduate School of Medicine　Department of Orthopaedic Surgery

2004/04 - 2008/03
Tohoku University　Faculty of Medicine　School of Medicine

1994/04 - 2000/03

Committee Memberships 8

日本関節病学会　評議員

2023 - Present
日本整形外科学会　リウマチ委員

2022 - Present
東日本整形災害外科学会評議員

2021 - Present
日本リウマチの外科学会評議員

2020 - Present
日本バイオマテリアル学会評議員

2020 - Present
日本骨代謝学会評議員

2020 - Present
日本骨粗鬆症学会評議員

2020 - Present
日本リウマチ学会評議員

2016 - Present

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Professional Memberships 10

日本人工関節学会
日本関節病学会
日本股関節学会
日本リウマチの外科学会
東日本整形外科学会
日本バイオマテリアル学会
日本骨代謝学会
日本骨粗鬆症学会
日本リウマチ学会
日本整形外科学会

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Research Interests 5

バイオマテリアル
Octacalcium Phosphate
Low Young's Modulus Titanium alloy
Osteoporosis
Rheumatoid Arthritis

Research Areas 1

Life sciences / Orthopedics /

Awards 17

日本脊椎関節炎学会 UCB Research Grant Award 2024

2024
日本バイオマテリアル学会シンポジウム2024 優秀ポスター賞（共著者）

2024
Top 10 The Tohoku Journal of Experimental Medicine Best Citation Awards (2021-2022)

2024
第7回日本脊椎関節炎学会七川アッヴィ賞

2024
第45回東北骨代謝・骨粗鬆症研究会優秀演題賞（共著者）

2024
東北大学医学系研究科教育貢献賞

2023　東北大学
第16回東北大学金属材料研究所附属新素材共同研究開発センター共同利用研究課題最優秀賞

2022
第65回日本リウマチ学会秀逸ポスター

2021
第42回東北骨代謝・骨粗鬆症研究会優秀演題賞（共著者）

2021
日本骨代謝学会優秀論文賞（JBMM論文賞）

2020
第41回東北骨代謝・骨粗鬆症研究会優秀演題賞（共著者）

2020
第62回日本リウマチ学会ベストポスター（共著者）

2018
日本股関節研究振興財団研究奨励賞

2016
武田科学振興財団研究奨励賞

2016
整形災害外科学研究助成財団財団奨励賞

2015
アメリカ骨代謝学会若手研究者賞

2011
東北大学整形外科同窓会学術振興基金学術業績賞(若松賞)

2008

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Papers 150

Hip internal rotation restriction and heel raise mechanics as risk factors for Jones fractures in youth football players

Tomoki Koyama, Yoshitomo Saita, Tomohiko Tateishi, Tomokazu Tanita, Hiroki Ukita, Toshiro Shima, Nobuyuki Itaya, Haruki Yaguchi, Nanako Yamamoto, Yu Mori, Toshimi Aizawa, Masashi Nagao

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology　42　15-20　2025/10
Publisher: Elsevier BV
DOI： 10.1016/j.asmart.2025.08.007 　

ISSN： 2214-6873
Thromboembolic risks after knee arthroplasty in patients with severe obesity: A large-scale analysis using Japanese medical claims data

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Journal of Orthopaedic Science　2025/09

DOI： 10.1016/j.jos.2025.08.007 　
Tranexamic acid in total hip arthroplasty: Nationwide evidence for reducing blood transfusions and post-operative complications

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kazuyoshi Baba, Ryuichi Kanabuchi, Yasuaki Kuriyama, Hiroaki Kurishima, Hideki Fukuchi, Hiroki Kawamata, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Journal of Joint Surgery and Research　2025/09

DOI： 10.1016/j.jjoisr.2025.06.004 　
Mathematical Model Analysis in Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Yu Mori, Naoko Mori, Takuya Izumiyama, Ryuichi Kanabuchi, Hiroshi Hatakeyama, Toshimi Aizawa

JCR: Journal of Clinical Rheumatology　2025/09

DOI： 10.1097/RHU.0000000000002245 　
Comparison of Cup Position and Perioperative Characteristics in Total Hip Arthroplasty Following Three Types of Pelvic Osteotomy

Ryuichi Kanabuchi, Yu Mori, Kazuyoshi Baba, Hidetatsu Tanaka, Hiroaki Kurishima, Yasuaki Kuriyama, Hideki Fukuchi, Hiroki Kawamata, Toshimi Aizawa

Medicina　2025/08/02

DOI： 10.3390/medicina61081407 　
More than a rebuttal: a field guide to letters to the editor in radiology

Naoko Mori, Yu Mori, Motoko Konno, Tomoki Tozawa, Kento Hatakeyama, Shunji Mugikura

European Journal of Radiology　112375-112375　2025/08
Publisher: Elsevier BV
DOI： 10.1016/j.ejrad.2025.112375 　

ISSN： 0720-048X
Impact of ongoing glucocorticoid use on postoperative complications following total knee arthroplasty: a Japanese nationwide propensity score–matched cohort study

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Ryuichi Kanabuchi, Hiroshi Hatakeyama, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Modern Rheumatology　2025/07/20

DOI： 10.1093/mr/roaf067 　
Response to the letter regarding "Increased complications of proximal femur fractures during the COVID-19 pandemic".

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Journal of bone and mineral metabolism　2025/07/18

DOI： 10.1007/s00774-025-01628-5 　
Increased Risks of Surgical Site Infection and In-Hospital Mortality Following Knee Arthroplasty in Dialysis Patients: Insights from a Japanese Nationwide Cohort. International-journal

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Tomoki Koyama, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

The Journal of arthroplasty　2025/07/12

DOI： 10.1016/j.arth.2025.07.010 　

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INTRODUCTION: Dialysis patients often develop advanced knee osteoarthritis, necessitating knee arthroplasty. Although total knee arthroplasty is commonly performed, limited data exist on perioperative complications among Japanese dialysis patients. This study uses a Japanese nationwide medical claims database to investigate the incidence of perioperative complications and mortality in dialysis versus non-dialysis patients undergoing knee arthroplasty. METHODS: A retrospective analysis was conducted using data from a Japanese nationwide database (April 2016 to March 2023). Propensity score matching was used to balance confounding variables, including age, sex, body mass index, surgical procedures, and comorbidities. A 1:1 propensity score-matched cohort of 1,923 dialysis and 1,923 non-dialysis patients was analyzed. Outcomes included in-hospital mortality, surgical site infections, and other complications. Multivariate logistic regression identified risk factors. RESULTS: Dialysis patients exhibited significantly higher in-hospital mortality and surgical site infection risks. The odds ratio for surgical site infection in dialysis patients was 2.17 (95% CI [confidence interval]: 1.31 to 3.61). The dialysis group demonstrated a significantly higher in-hospital mortality risk compared to the non-dialysis group (P < 0.0001). No in-hospital deaths were observed among non-dialysis patients post-matching, precluding the calculation of an odds ratio. Bilateral simultaneous surgery emerged as an additional independent risk factor, with an odds ratio of 9.94 (95% CI: 1.95 to 50.74) in dialysis patients. CONCLUSION: This propensity score-matched study highlights significantly elevated surgical site infection and in-hospital mortality risks for dialysis patients undergoing knee arthroplasty. These findings underscore the necessity for careful perioperative management and the avoidance of high-risk procedures, such as bilateral simultaneous surgeries, in dialysis patients.
High risk of postoperative complications in dialysis patients undergoing total hip arthroplasty: a database study of Japanese nationwide medical claims. International-journal

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kazuyoshi Baba, Hideki Fukuchi, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Scientific reports　15　(1)　24211-24211　2025/07/07

DOI： 10.1038/s41598-025-02829-8 　

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Dialysis patients who develop degenerative hip disease or femoral neck fractures may require total hip arthroplasty, and their comorbidities predispose them to complications. This study aimed to evaluate whether dialysis was associated with early postoperative complications using a large database of Japanese. In this cohort study, using the Japanese National Administrative Diagnosis Procedure Combination database on THA for patients on hemodialysis or not from December 2011 to March 2023, we assessed the surgical-related complications, medical complications, and mortality during hospitalization after propensity score matching by age, sex, BMI, and comorbidities. A total of 2,111 pairs of patients on hemodialysis and non-dialysis were included. In THA for patients on hemodialysis, the significant odds ratios for various complications were as follows: dislocation (2.616, 95% CI: 1.282 to 5.338, p < 0.01), reoperation (2.104, 95% CI: 1.222 to 3.623, p < 0.01), deep vein thrombosis (0.407, 95% CI: 0.286 to 0.579, p < 0.01), cerebrovascular events (4.426, 95% CI: 1.495 to 13.10, p < 0.01). These findings help identify postoperative THA risks for patients on dialysis, suggesting that more attention should be paid to preoperative planning and postoperative care.
MRI-based predictors of spinal ankylosis progression: ESSR framework for axial spondyloarthritis

Yu Mori, Naoko Mori, Takuya Izumiyama, Ryuichi Kanabuchi, Hiroshi Hatakeyama, Toshimi Aizawa

Modern Rheumatology　2025/07/05

DOI： 10.1093/mr/roaf015 　
Postoperative risks of type 2 diabetes in elderly hip fracture patients: a propensity score-matched study

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Journal of Bone and Mineral Metabolism　2025/07/01

DOI： 10.1007/s00774-025-01624-9 　

ISSN： 0914-8779 1435-5604

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<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Introduction</jats:title> <jats:p>Type 2 diabetes is associated with an increased risk of fragility fractures, even in individuals with normal or high bone mineral density. However, the impact of type 2 diabetes on postoperative outcomes after hip fracture surgery in elderly Japanese patients remains unclear. This study evaluated the association between type 2 diabetes and postoperative complications, including in-hospital mortality, using a nationwide database in Japan.</jats:p> </jats:sec> <jats:sec> <jats:title>Materials and methods</jats:title> <jats:p>A retrospective cohort study was conducted using the Diagnosis Procedure Combination (DPC) database from April 2016 to March 2022. Patients aged ≥ 65 years who underwent hip fracture surgery were included. Propensity score matching (1:1) was performed to adjust for confounders. Logistic regression analyses were used to assess associations between type 2 diabetes and outcomes.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Of the 474,293 eligible patients included in this study, 18.5% were identified as having comorbid type 2 diabetes. Following 1:1 propensity score matching, the final analytic cohorts each comprised 83,283 patients. Although statistically significant, the presence of type 2 diabetes was associated with only modest increases in the risks of postoperative myocardial infarction (risk difference [RD]: 0.0007), cognitive dysfunction (RD: 0.0029), and in-hospital mortality (RD: 0.0045), with all comparisons yielding p-values of less than 0.0001. Additionally, the length of hospital stay was longer among patients with type 2 diabetes.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Although the absolute risk differences were small, type 2 diabetes remains an independent risk factor for adverse postoperative outcomes following hip fracture surgery in elderly Japanese patients. Tailored perioperative strategies may help optimize outcomes in this vulnerable population.</jats:p> </jats:sec>
An MSC Chemotactic and Bone-Replaceable PLGA Material Involving Chemokine Loading OCP for Orthopedic Bone Defect Repair

Yasuaki Kuriyama, Ryo Hamai, Yu Mori, Ryuichi Kanabuchi, Kazuyoshi Baba, Kaori Tsuchiya, Toshimi Aizawa, Osamu Suzuki

ACS Applied Bio Materials　2025/06/23
Publisher: American Chemical Society (ACS)
DOI： 10.1021/acsabm.5c00549 　

ISSN： 2576-6422

eISSN： 2576-6422
Increased complications of proximal femur fractures during the COVID-19 pandemic: a nationwide medical claims database study in Japan.

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Journal of bone and mineral metabolism　2025/06/10

DOI： 10.1007/s00774-025-01611-0 　

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INTRODUCTION: Coronavirus disease 2019 (COVID-19) is a worldwide pandemic, and mortality increases in elderly patients with comorbidities. This study aims to examine the in-hospital complications and mortality for elderly patients with proximal femur fractures during the COVID-19 pandemic or countermeasure periods. MATERIALS AND METHODS: The proximal femur fractures undergoing surgery during the COVID-19 pandemic or countermeasure period were compared with the pre-pandemic in a Japanese national inpatient data. The assessed outcomes were the development of pneumonia, deep vein thrombosis (DVT), pulmonary embolism (PE), and mortality during hospitalization in two periods, and those for COVID-19-positive patients. RESULTS: A total of 284,922 proximal femur fractures aged over 65 years were included. In the COVID-19 pandemic period compared to the pre-pandemic, the odds of pneumonia, DVT, PE, and mortality decreased to 0.942 (95% confidence interval [CI]: 0.901 - 0.986, P = 0.0102) and 0.839 (95% CI: 0.745 - 0.946, P = 0.004), increased to 1.153 (95% CI: 1.112 - 1.195, P < 0.001), and 1.048 (95% CI: 0.982 - 1.118, P = 0.1554), respectively. For COVID-19 positivity at admission, the odds of PE increased significantly to 12.95 (95% CI: 8.795 - 19.06, P < 0.001). For COVID-19 positivity during hospitalization, the odds of pneumonia and mortality were increased to 2.896 (95% CI: 1.820 - 4.608, P < 0.001) and 6.303 (95% CI: 3.440 - 11.55, P < 0.001), respectively. CONCLUSION: These findings alert healthcare professionals and patients to the elevated complications, especially PE rate for proximal femoral fracture with COVID-19 positive.
Increased risk of deep vein thrombosis and surgical site infection in cemented total knee arthroplasty: A nationwide propensity score-matched study in Japan. International-journal

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Kento Harada, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Archives of orthopaedic and trauma surgery　145　(1)　327-327　2025/06/02

DOI： 10.1007/s00402-025-05943-4 　

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INTRODUCTION: Total knee arthroplasty (TKA) is a widely used treatment for advanced knee osteoarthritis. While cemented fixation is the standard technique, cementless fixation has demonstrated comparable long-term outcomes. However, the association between cement use and postoperative complications, including venous thromboembolism and surgical site infections, remains unclear, particularly in Japanese patients. This study aimed to investigate the incidence of postoperative complications in cemented and cementless TKA using a nationwide database. METHODS: A nationwide cohort study was conducted using Japan's DPC database from April 2016 to March 2023. Patients who underwent TKA were identified, and postoperative complications, including deep vein thrombosis, pulmonary embolism, pneumonia, cerebrovascular events, postoperative cognitive dysfunction, and surgical site infection, were analyzed. One-to-one propensity score (PS) matching was performed based on age, sex, body mass index, type of anesthesia, simultaneous bilateral surgery, Charlson comorbidity index, and comorbidities to ensure comparability. Statistical analyses included χ² tests, Student's t-tests, and multivariate logistic regression analysis. RESULTS: A total of 228,595 patients met the eligibility criteria, with 21,906 matched pairs in the cemented and cementless groups after PS matching. The incidence of deep vein thrombosis (OR: 1.231, 95% CI: 1.151-1.316, p < 0.0001) and surgical site infection (OR: 1.716, 95% CI: 1.420-2.073, p < 0.0001) was significantly higher in the cemented group. No significant differences were observed in pulmonary embolism or other complications. CONCLUSION: Cement application was associated with an increased risk of deep vein thrombosis and surgical site infection. These findings suggest that careful perioperative management may be warranted in patients undergoing cemented TKA.
Case Report: Xanthogranulomatous Osteomyelitis of the Femur: A Rare Mimic of Malignant Bone Tumors. International-journal

Hiroshi Hatakeyama, Yu Mori, Shinichirou Yoshida, Jun Iwatsu, Hirotaka Kurata, Shin Hitachi, Mika Watanabe, Toshimi Aizawa

International journal of rheumatic diseases　28　(6)　e70313　2025/06

DOI： 10.1111/1756-185X.70313 　
Microstructures and mechanical properties of anodic oxides on TiNbSn implant alloys

N. Masahashi, M. Kubota, H. Inoue, Y. Mori, K. Ohmura

Thin Solid Films　140674-140674　2025/06

DOI： 10.1016/j.tsf.2025.140674 　

ISSN： 0040-6090
Biocompatible functional surface of titanium-based implant materials

Naoya Masahashi, Yu Mori, Hiroyuki Inoue

International Materials Reviews　70　(6)　465-496　2025/05/23

DOI： 10.1177/09506608251345899 　

ISSN： 0950-6608 1743-2804

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<jats:p> Titanium (Ti) and its alloys are widely used in orthopedic and dental implants owing to their high biocompatibility with tissues, low toxicity, and excellent mechanical properties, such as high strength, fatigue strength, and corrosion resistance. Total hip arthroplasty (THA) is predicted to rise from1.8 million in 2015 to 2.8 million in 2050, and the demand for Ti-based THA is also increasing. The biocompatibility of Ti originates from the several-nanometer-thick oxide layer present on its surface, which inhibits the redox reactions. The oxide forms spontaneously on the surface upon exposure to air and stays in thermodynamic equilibrium; however, it is easily disrupted by the interfacial shear stress owing to the low wear resistance of Ti. Ti exposed to corrosive body fluids elutes metal ions, generating wear debris in the biological fluids and tissues. This causes injury and disease, incites allergies, and promotes the formation of granulomas and even carcinomas. Furthermore, poor osseointegration due to poor adhesion with adjacent bone causes the loosening of the implant-bone interface and slows the healing process. To overcome these drawbacks of implant Ti materials, surface modifications using biocompatible TiO <jats:sub>2</jats:sub> are expected for imparting biofunctions such as osseointegration, antivirus activity, and tribocorrosion. Although various methods have been studied for the fabrication of TiO <jats:sub>2</jats:sub> on Ti alloys, anodic oxidation has attracted considerable attention owing to its advantages. This review aims to provide a comprehensive, evidence-based overview of current studies on the osseointegration, antimicrobial properties, and cytotoxicity of surface-modified implant Ti alloys, in addition to a brief introduction to different metallic biomaterials. </jats:p>
Thromboembolic and infectious complication risks in TKA and UKA: evidence from a Japanese nationwide cohort

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Kento Harada, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Knee Surgery & Related Research　2025/05/08

DOI： 10.1186/s43019-025-00273-6 　
Biomechanical Comparison of Transverse Capsulotomy Versus Longitudinal Capsulotomy of the Hip: A Cadaveric Study

Hidetatsu Tanaka, Kazuyoshi Baba, Yu Mori, Yasuaki Kuriyama, Ryuichi Kanabuchi, Eiji Itoi, Toshimi Aizawa

Orthopaedic Journal of Sports Medicine　2025/05

DOI： 10.1177/23259671251334145 　
Effectiveness of Stress Shielding Prevention Using a Low Young’s Modulus Ti-33.6Nb-4Sn Stem: A 7-Year Follow-Up Study

Kazuyoshi Baba, Yu Mori, Hidetatsu Tanaka, Ryuichi Kanabuchi, Yasuaki Kuriyama, Hiroaki Kurishima, Kentaro Ito, Masayuki Kamimura, Daisuke Chiba, Toshimi Aizawa

Medical Sciences　2025/05/01

DOI： 10.3390/medsci13020051 　
Increased Periprosthetic Joint Infection Rate Following Total Knee Arthroplasty in Rheumatoid Arthritis Patients: Insights From a Japanese Nationwide Medical Claims Database Study. International-journal

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Ryuichi Kanabuchi, Hiroshi Hatakeyama, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

International journal of rheumatic diseases　28　(5)　e70249　2025/05

DOI： 10.1111/1756-185X.70249 　

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INTRODUCTION: Advances in pharmacological treatments have reduced joint deformities in rheumatoid arthritis (RA), leading to a decline in total knee arthroplasty (TKA) among RA patients. However, RA remains associated with higher risks of postoperative complications. This study compares postoperative complications during hospitalization in patients with RA and osteoarthritis (OA) undergoing TKA in Japan. METHODS: This retrospective cohort study utilized data from the Japanese Diagnosis Procedure Combination database from April 2016 to March 2023. Patients who underwent TKA were identified, and propensity score (PS) matching was performed to balance age, sex, body mass index, simultaneous surgeries, and comorbidities, resulting in 9048 matched pairs. Outcomes included periprosthetic joint infections (PJI), cognitive dysfunction, deep vein thrombosis (DVT), pulmonary embolism (PE), and periprosthetic fractures. Statistical analyses were conducted using multivariate logistic regression with a significance threshold of p < 0.01. RESULTS: RA patients had higher risks of PJI (odds ratio [OR]: 1.473, 95% CI: 1.134-1.912, p = 0.004) and postoperative cognitive dysfunction (OR: 1.721, 95% CI: 1.190-2.488, p = 0.004) compared to OA patients. In contrast, no significant differences were observed in the incidence of DVT, PE, or periprosthetic fractures. CONCLUSION: RA patients undergoing TKA are at increased risk of PJI and cognitive dysfunction, highlighting the need for tailored perioperative management. These findings provide important insights into optimizing outcomes for RA patients.
Comparison of outcomes and cost-effectiveness of simultaneous and staged total hip arthroplasty using the anterolateral-supine approach

Hiroaki Kurishima, Norikazu Yamada, Atsushi Noro, Hidetatsu Tanaka, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Surgery and Research　2025/04/29

DOI： 10.1186/s13018-025-05840-x 　

ISSN： 1749-799X
Biomechanical and Clinical Validation of a Modulus-Graded Ti-Nb-Sn Femoral Stem for Suppressing Stress Shielding in Total Hip Arthroplasty

Yu Mori, Hidetatsu Tanaka, Hiroaki Kurishima, Ryuichi Kanabuchi, Naoko Mori, Keisuke Sasagawa, Toshimi Aizawa

Applied Sciences　2025/04/26

DOI： 10.3390/app15094827 　
Post-brachytherapy patient management: the need for integrated health information systems in radiation safety and mortality tracking.

Naoko Mori, Yuki Wada, Satoshi Kumagai, Yu Mori, Hiroshi Sakamoto, Shunji Mugikura

Japanese journal of radiology　2025/04/25

DOI： 10.1007/s11604-025-01793-7 　
Limited effect of preoperative dental clearance on infection prevention in primary or revision hip arthroplasty for high- and low-risk groups

Kazuyoshi Baba, Hidetatsu Tanaka, Ryuichi Kanabuchi, Yasuaki Kuriyama, Daisuke Chiba, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Reports　2025/04

DOI： 10.1016/j.jorep.2025.100565 　
Perspectives on MRI sequences and clustering techniques in predicting osteosarcoma treatment response

Yu Mori, Naoko Mori

La radiologia medica　2025/03/21

DOI： 10.1007/s11547-025-01999-9 　

ISSN： 1826-6983
Increased early complication rates following total hip arthroplasty in rheumatoid arthritis patients based on a Japanese nationwide medical claims database study

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Ryuichi Kanabuchi, Yasuaki Kuriyama, Hiroshi Hatakeyama, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Scientific Reports　2025/03/17

DOI： 10.1038/s41598-025-94342-1 　

ISSN： 2045-2322
Nationwide database study of postoperative sequelae and in-hospital mortality in super-elderly hip fracture patients

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Journal of Bone and Mineral Metabolism　2025/03

DOI： 10.1007/s00774-024-01564-w 　
Enhanced osteogenic capacity of octacalcium phosphate involving adsorption of stromal-derived factor-1 in a standardized defect of a rat femur. International-journal

Ryuichi Kanabuchi, Ryo Hamai, Yu Mori, Soshi Hamada, Yukari Shiwaku, Yuko Sai, Kaori Tsuchiya, Toshimi Aizawa, Osamu Suzuki

Journal of materials science. Materials in medicine　36　(1)　23-23　2025/02/28

DOI： 10.1007/s10856-025-06872-9 　

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This study investigated whether octacalcium phosphate (OCP) enhances bone regeneration through its synergistic effect with stromal-derived factor-1 (SDF-1). Recombinant SDF-1 (0.5-5.0 μg) was combined with OCP granules through lyophilization. OCP/SDF-1 granules were implanted into a rat femoral standardized defect for 2 and 4 weeks and subjected to histomorphometry, C-X-C motif chemokine receptor 4 (CXCR4) and osteocalcin immunohistomorphometry, and tartrate-resistant acid phosphatase (TRAP) staining. Calcium-deficient hydroxyapatite (CDHA) was used as a control for in vitro analyses. Mesenchymal stem cell (MSC) migration was estimated using a Transwell system with OCP/SDF-1. SDF-1 release from OCP/SDF-1 into the supernatant was determined without cells. SDF-1 adsorption in 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid buffer onto OCP, the chemical structure of OCP immersed in the medium using Fourier transform infrared spectroscopy, and the degree of supersaturation of the medium were determined. Bone regeneration and OCP degradation were enhanced the most by 1.0 μg of OCP/SDF-1 at 2 weeks after implantation by CT analysis and increasing CXCR4-positive, osteocalcin-positive, and TRAP-positive cells accumulation around the OCP. MSC migration increased until 48 h in the following order: SDF-1 only, CDHA/SDF-1, and OCP/SDF-1, with the greatest effect with 1.0 μg of SDF-1 than from OCP. CDHA promoted a greater release than OCP at 48 h. The physicochemical analyses indicated that SDF-1 interacted with OCP through Freundlich-type adsorption and that the adsorption controlled SDF-1 release from OCP during the hydrolysis into CDHA. Therefore, leveraging its molecular affinity for the OCP surface, OCP/SDF-1 facilitates MSC migration and enhances bone formation by ensuring the controlled, sustained release of SDF-1 from OCP.
Case Report: A Diagnostic Challenge in Adult‐Onset Hypophosphatasia With Persistent Polyarthralgia

Ryuichi Kanabuchi, Yu Mori, Hiroshi Hatakeyama, Mishio Chiba, Naoko Mori, Toshimi Aizawa

International Journal of Rheumatic Diseases　28　(2)　2025/02/14
Publisher: Wiley
DOI： 10.1111/1756-185x.70136 　

ISSN： 1756-1841

eISSN： 1756-185X
Preserving medial iliofemoral ligament avoids excessive leg lengthening in total hip arthroplasty using anterolateral-supine approach

Hiroaki Kurishima, Norikazu Yamada, Atsushi Noro, Hidetatsu Tanaka, Shusuke Takahashi, Kyota Tsuchida, Yu Mori, Toshimi Aizawa

Journal of Orthopaedics　2025/02

DOI： 10.1016/j.jor.2024.09.004 　
Preoperative Osteoporosis Treatment Reduces Stress Shielding in Total Hip Arthroplasty

Ryuichi Kanabuchi, Yu Mori, Kazuyoshi Baba, Hidetatsu Tanaka, Yasuaki Kuriyama, Hideki Fukuchi, Hiroki Kawamata, Toshimi Aizawa

Medical Sciences　2025/01/28

DOI： 10.3390/medsci13010010 　
Does Osteonecrosis of the Femoral Head Increase Early Complication Rates After Total Hip Arthroplasty? A Japanese Nationwide Medical Claims Database Study

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Yasuaki Kuriyama, Hiroki Kawamata, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

The Journal of Arthroplasty　2025/01/23

DOI： 10.1016/j.arth.2025.01.029 　

ISSN： 0883-5403
Limited impact of weekend admissions on hip fracture outcomes in elderly patients: A study from a Japanese nationwide medical claims database.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Geriatrics & gerontology international　2024/12/04

DOI： 10.1111/ggi.15041 　

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AIM: The effectiveness of early surgery in preventing complications in elderly Japanese hip fracture patients and the impact of weekend hospitalization need further investigation. The purpose of this study was to determine whether weekend hospitalization affects the incidence of various sequelae and death during hospitalization in elderly hip fracture patients using a comprehensive Japanese hip fracture case database. METHODS: We retrospectively analyzed the Japanese National Administrative DPC (Diagnosis Procedure Combination) database from April 2016 to March 2022. During this period, approximately 1100 DPC-affiliated hospitals consistently provided medical records with consent for the study. The study focused on weekend hospitalizations and investigated the associations with postoperative pneumonia, pulmonary embolism, myocardial infarction, urinary tract infection, acute renal dysfunction, dementia, and in-hospital mortality after propensity score matching. Owing to the large population size of the study, significance levels were strictly enforced, and a P-value < 0.001 was considered statistically significant. RESULTS: After performing propensity score matching based on age, sex, and comorbidities, 111 035 patient pairs were identified, comparing those admitted on weekends versus weekdays. The analysis showed no heightened risk of sequelae for those admitted during the weekend compared with weekdays. Additionally, there was a slight trend toward higher mortality risk during weekend hospital stays; however, the increase was insignificant, with a hazard ratio of 1.071 (95% confidence interval: 1.005-1.140, P = 0.03). CONCLUSION: The results of this study indicate that weekend hospitalization for elderly patients with hip fractures is not definitively associated with an increase in various sequelae or in-hospital mortality and that the importance of early surgery for elderly patients with hip fractures may be recognized and promoted in Japan. Geriatr Gerontol Int 2024; ••: ••-••.
Case Report: SAPHO Syndrome With Refractory Shoulder Pain and Severe Acne. International-journal

Mishio Chiba, Yu Mori, Ryuichi Kanabuchi, Hiroshi Hatakeyama, Naoko Mori, Toshimi Aizawa

International journal of rheumatic diseases　27　(12)　e15441　2024/12

DOI： 10.1111/1756-185X.15441 　
Magnetic Resonance Imaging Texture Analysis Based on Intraosseous and Extraosseous Lesions to Predict Prognosis in Patients with Osteosarcoma

Yu Mori, Hainan Ren, Naoko Mori, Munenori Watanuki, Shin Hitachi, Mika Watanabe, Shunji Mugikura, Kei Takase

Diagnostics　2024/11/15

DOI： 10.3390/diagnostics14222562 　
Total Knee Arthroplasty in Patients With Ankle Osteoarthritis Affects Contralateral Ankle Alignment and Postoperative Outcome of Total Knee Arthroplasty. International-journal

Tomoki Koyama, Yu Mori, Shunsuke Utsumi, Kento Harada, Kentaro Ito, Hidetatsu Tanaka, Takashi Aki, Hideaki Nagamoto, Masayuki Kamimura, Toshimi Aizawa

Foot & ankle international　10711007241283783-10711007241283783　2024/11/06

DOI： 10.1177/10711007241283783 　

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BACKGROUND: This study investigated the impact of total knee arthroplasty (TKA) on the alignment of the ankle joint, focusing on changes in coronal alignment of both ankles. METHODS: This retrospective study, conducted at our hospital, included 64 patients older than 70 years who underwent TKA for varus knee osteoarthritis (OA). Using full-length standing radiographs of both lower extremities taken preoperatively and 6 months postoperatively, we assessed ankle OA grading based on the Takakura-Tanaka classification and measured mechanical hip-knee-ankle (mHKA) and the tibiotalar angle (TTA) on both the surgical and contralateral side. Additionally, we examined the impact of ankle OA on postoperative clinical scores, the Knee injury and Osteoarthritis Outcome Score, following TKA. RESULTS: Based on the classification, ankle OA stage 2 or higher was present in 13 cases on the surgical side and 13 cases on the contralateral side. On the surgical side, mHKA changed from 12.2 to 1.8 degrees varus (P < .001) and TTA from 1.7 to 1.0 degrees varus (P = .002). On the contralateral side, mHKA changed from 4.0 to 5.4 degrees varus (P = .04), and TTA from 2.7 to 3.0 degrees varus (P < .001). In ankle OA stage 2 or higher patients, contralateral TTA changed from 5.2 to 6.5 degrees varus (P < .001) and unchanged in stage 1 patients. Ankle OA stage 2 or higher patients had worse ADL outcomes than stage 1 patients (score: 67.2 and 78.3, respectively, P = .03). CONCLUSION: This study suggests an apparent interrelationship between knee and ankle OA and the potential negative influence of TKA on ankle OA.
Efficacy of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite Implantation for Miniature Swine Lumbar Interbody Fusion

Yu Mori, Ryo Hamai, Ryuichi Kanabuchi, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa, Osamu Suzuki

The Tohoku Journal of Experimental Medicine　2024/11
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2024.j138 　

ISSN： 0040-8727

eISSN： 1349-3329
TiNbSn Alloy Plates with Low Young's Modulus Modulates Interfragmentary Movement and Promote Osteosynthesis in Rat Femur

Tomoki Koyama, Yu Mori, Masayuki Kamimura, Hidetatsu Tanaka, Rui Tome, Ketaro Ito, Masashi Koguchi, Naoko Mori, Toshimi Aizawa

Journal of the Mechanical Behavior of Biomedical Materials　106820-106820　2024/11
Publisher: Elsevier BV
DOI： 10.1016/j.jmbbm.2024.106820 　

ISSN： 1751-6161
Impact of Aging and Knee Osteoarthritis on Lower Limb Alignment and CPAK Classification: Gender Differences in a Japanese Cohort

Kento Harada, Yu Mori, Masayuki Kamimura, Takashi Aki, Tomoki Koyama, Toshimi Aizawa

Journal of Clinical Medicine　2024/10/19

DOI： 10.3390/jcm13206250 　
Prospects of perfusion contrast-enhanced ultrasound (CE-US) in diagnosing axillary lymph node metastases in breast cancer: a comparison with lymphatic CE-US

Naoko Mori, Li Li, Masazumi Matsuda, Yu Mori, Shunji Mugikura

Journal of Medical Ultrasonics　2024/10

DOI： 10.1007/s10396-024-01444-w 　

ISSN： 1613-2254 1346-4523
Advances in titanium alloys and orthopedic implants: new titanium alloys and future research directions

Yu Mori, Naoko Mori

Bio-Design and Manufacturing　2024/09/30
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s42242-024-00314-1 　

ISSN： 2096-5524

eISSN： 2522-8552
Rheumatoid arthritis increases complication risks in elderly hip fracture patients.: A Japanese nationwide medical claims database study. International-journal

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Ryuichi Kanabuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Modern rheumatology　2024/09/05

DOI： 10.1093/mr/roae088 　

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OBJECTIVES: Rheumatoid arthritis (RA) is a common autoimmune disorder characterized by chronic inflammation and periarticular bone loss, leading to systemic osteoporosis and heightened fracture susceptibility, especially hip fractures among the elderly. This study aimed to evaluate the outcomes and complications associated with hip fractures in patients with RA relative to those without RA. METHODS: Using the Japanese National Administrative Diagnosis Procedure Combination (DPC) database, we examined cases of femoral neck fractures from April 2016 to March 2023. After one to three propensity score matching for age, sex, and complications, we examined the association between RA, complications, and mortality during hospitalization in elderly patients with hip fractures. RESULTS: The findings revealed that elderly Japanese RA patients with hip fractures had significantly higher complications of pneumonia than elderly hip fracture patients without RA, with a ratio of 1.232 (95% CI: 1.065-1.426, p=0.0056), and pulmonary embolism, with a ratio of 1.155 (95% CI: 1.036-1.287, p=0.009) in multivariate logistic regression analyses. Although not significantly elevated, it also found a trend toward higher mortality during hospitalization, with a ratio of 1.179 (95% CI: 0.973-1.429, p=0.096). CONCLUSIONS: A substantial study based on the Japanese DPC database revealed a significant association between RA and increased complications, including pneumonia and pulmonary embolism. On the other hand, there was a nonsignificant but higher trend for risk of mortality during hospitalization for hip fracture in elderly RA patients. Implementing preventive strategies is essential to minimizing complications in the treatment of hip fractures in patients with RA.
Surgery within Two Days of Admission Reduces Complications and Mortality of Patients with Trochanteric Femur Fractures: A Japanese DPC Study

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

The Tohoku Journal of Experimental Medicine　2024/09
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2024.j093 　

ISSN： 0040-8727

eISSN： 1349-3329
Advancing osteoporosis diagnosis and fracture prediction: role of quantitative CT and future research directions

Yu Mori, Naoko Mori

Archives of Orthopaedic and Trauma Surgery　2024/08/24

DOI： 10.1007/s00402-024-05512-1 　
Elucidation of Factors Influencing Spinal Ankylosis in Patients with Axial Spondyloarthritis

Takuya Izumiyama, Yu Mori, Ryuichi Kanabuchi, Hiroshi Hatakeyama, Toshimi Aizawa

Modern Rheumatology　2024/08/23
Publisher: Oxford University Press (OUP)
DOI： 10.1093/mr/roae075 　

ISSN： 1439-7595

eISSN： 1439-7609

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Abstract Objective Spondyloarthritis encompasses conditions such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Advanced axial spondyloarthritis causes significant spinal fusion, affecting daily activities. Recent therapeutic agents have enhanced the control of inflammation, yet they do not consistently stop the axial progression. This study aimed to identify factors influencing the progression of axial lesions over a two-year period in Japanese patients with axial spondyloarthritis. Methods This retrospective and cross-sectional study included 47 axial spondyloarthritis patients. Spinal lesions were assessed using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Patients were categorized into progressive and non-progressive groups based on changes in their mSASSS scores. Various clinical parameters were analyzed for correlation with ankylosis progression. Results The study found no significant correlation between ankylosis progression and traditional factors, including the level of inflammation or the use of biologics. However, modified Health Assessment Questionnaire (mHAQ) scores were associated with disease progression. The baseline mSASSS was another significant factor, underscoring the importance of early detection and management. Conclusion This study showed that patient-reported outcomes and baseline mSASSS scores are crucial for assessing axial spondyloarthritis progression. This underscores the need for a comprehensive treatment strategy that addresses both clinical indicators and patient-reported outcomes.
Large language model may assist diagnosis of SAPHO syndrome by bone scintigraphy

Yu Mori, Takuya Izumiyama, Ryuichi Kanabuchi, Naoko Mori, Toshimi Aizawa

Modern Rheumatology　2024/08/20

DOI： 10.1093/mr/road115 　
Surgery on admission and following day reduces hip fracture complications: a Japanese DPC study.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Journal of bone and mineral metabolism　2024/07/11

DOI： 10.1007/s00774-024-01534-2 　

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INTRODUCTION: The efficacy of early surgery in preventing complications among Japanese elderly patients with hip fractures requires further investigation. This study aims to use a comprehensive Japanese hip fracture case database to determine whether surgery within the day of admission and the following day reduces the incidence of complications and mortality during hospitalization in elderly hip fracture patients. MATERIALS AND METHODS: We retrospectively analyzed the Japanese National Administrative DPC (Diagnosis Procedure Combination) database from April 2016 to March 2022. Approximately 1100 DPC-affiliated hospitals consistently provided medical records with consent for research. The study investigated the association between postoperative pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization after propensity score matching, focusing on surgeries conducted on the day of admission and the following day. RESULTS: After one-to-one propensity score matching for age, gender, and comorbidity, we identified 146,441 pairs of patients who underwent surgery either within the day of admission and the following day or after the third day of admission. Surgery on the third day or later was independently associated with increased risks of pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization with risk ratios of 1.367 (95% CI 1.307-1.426), 1.328 (95% CI 1.169-1.508), 1.338 (95% CI 1.289-1.388), and 1.167 (95% CI 1.103-1.234), respectively. CONCLUSION: A comprehensive study of elderly Japanese patients with hip fractures in the DPC database showed that surgery on admission and the following day is crucial for preventing complications like pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization.
Does total hip arthroplasty in elderly patients with femoral neck fractures reduce complications? A Japanese DPC study

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Journal of Orthopaedic Science　2024/07
Publisher: Elsevier BV
DOI： 10.1016/j.jos.2024.06.011 　

ISSN： 0949-2658
Prone position magnetic resonance imaging for the mandibular bone: enhancing image quality to perform texture analysis for medication-related osteonecrosis of the jaw and carcinoma of the lower gingiva

Takahiro Otani, Hirokazu Yoshida, Daichi Sugawara, Yu Mori, Naoko Mori

Oral Radiology　2024/07

DOI： 10.1007/s11282-024-00754-6 　

ISSN： 1613-9674 0911-6028
Selection of the phase of dynamic contrast-enhanced magnetic resonance imaging and use of the voxel-based enhancement maps may facilitate the assessment of clinical disease activity in patients with rheumatoid arthritis.

Yu Mori, Naoko Mori

Japanese journal of radiology　2024/06/24

DOI： 10.1007/s11604-024-01620-5 　
Acetabular coverage exerts minimal influence on femoral head collapse and the necessity for surgical intervention in patients with osteonecrosis of femoral head

Yasuaki Kuriyama, Hidetatsu Tanaka, Kazuyoshi Baba, Ryuichi Kanabuchi, Yu Mori, Toshimi Aizawa

International Orthopaedics　2024/06/20
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00264-024-06238-w 　

ISSN： 0341-2695

eISSN： 1432-5195

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Abstract Purpose The acetabular coverage in osteonecrosis of the femoral head (ONFH) affects the need for surgical intervention, and the collapse of the femoral head remains unclear. This study aimed to evaluate the relation between the acetabular coverage and the need for surgical treatment and femoral head collapse. Methods The study included 158 patients with 252 hips with glucocorticoid administration and idiopathic ONHF without osteoarthritis changes. The mean age at the first visit was 45.2 years, and the mean follow-up period was 92.2 months. All ONFH hips were subsequently divided into two groups: those needing surgical intervention and those without surgery. Additionally, it divided 167 initially non-collapsed hips into those that either later collapsed or not. Radiographic parameters with the centre-edge angle, acetabular roof obliquity, sharp angle, and necrotic location, following the guidelines of the Japanese Investigation Committee, were evaluated. Results There were no significant differences in radiographic parameters between the 106 hips that underwent surgery and the 146 hips without surgery. Among the 167 hips without initial collapse, 91 eventually collapsed while 76 did not; their radiographic findings have no significant differences. The necrotic locations were significantly larger in hips requiring surgical intervention or femoral head collapse. Furthermore, 21.8% (55 out of 252 hips) had acetabular dysplasia, which did not significantly correlate with the necessity for surgical treatment or the incidence of femoral head collapse. Conclusions Acetabular coverage has little effect on the necessity for surgical treatment and femoral head collapse in ONFH patients over a long-term follow-up.
Letter to the Editor from Mori and Mori: “Sequential Therapy for the Long-Term Treatment of Postmenopausal Osteoporosis”

Yu Mori, Naoko Mori

The Journal of Clinical Endocrinology & Metabolism　2024/06/17

DOI： 10.1210/clinem/dgae083 　

ISSN： 0021-972X 1945-7197
A Review of the Impacts of Implant Stiffness on Fracture Healing

Yu Mori, Masayuki Kamimura, Kentaro Ito, Masashi Koguchi, Hidetatsu Tanaka, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

Applied Sciences　2024/03/07

DOI： 10.3390/app14062259 　
Clinical Outcomes of Bipolar Hemiarthroplasty with a Conjoined Tendon-Preserving Posterior Approach for Femoral Neck Fractures

Tanaka, H., Mori, Y., Noro, A., Yano, T., Aizawa, T., Masuda, K.

Medicina (Lithuania)　60　(3)　2024/02/21

DOI： 10.3390/medicina60030356 　

ISSN： 1648-9144 1010-660X
SAPHO syndrome with refractory mandibular osteitis

Mori, Y., Izumiyama, T., Kanabuchi, R., Mori, N., Aizawa, T.

International Journal of Rheumatic Diseases　27　(2)　2024/02

DOI： 10.1111/1756-185X.15059 　

ISSN： 1756-185X 1756-1841
Minimal Influence on Muscle Strength and Patient Reported Outcome Measures by Conjoined Tendon Detachment in Anterolateral Muscle-Sparing Total Hip Arthroplasty

Hidetatsu Tanaka, Norikazu Yamada, Hiroaki Kurishima, Yu Mori, Toshimi Aizawa

Indian Journal of Orthopaedics　2024/01/05
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s43465-023-01080-5 　

ISSN： 0019-5413

eISSN： 1998-3727
Chronic proximal tibial aseptic osteitis diagnosed as SAPHO syndrome ameliorated with oral methotrexate: A case report

Takuya Izumiyama, Yu Mori, Yasuaki Kuriyama, Ryuichi Kanabuchi, Naoko Mori, Toshimi Aizawa

JOS Case Reports　2024/01

DOI： 10.1016/j.joscr.2024.01.002 　

ISSN： 2772-9648
Different types of hip fragility fractures have different values of 25-hydroxyvitamin D and parathyroid hormone

Atsuko Kanno, Toshitake Aizawa, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Science　29　(1)　256-261　2024/01
Publisher: Elsevier BV
DOI： 10.1016/j.jos.2022.11.003 　

ISSN： 0949-2658
Anticipations for advancement of non-contrast MRI sequences suitable for longitudinal studies of rheumatoid arthritis

Yu Mori, Naoko Mori

La radiologia medica　2023/11/10
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11547-023-01745-z 　

eISSN： 1826-6983
Validating MRI and ultrasound findings to predict bone destruction in rheumatoid arthritis

Yu Mori, Naoko Mori, Toshimi Aizawa

Modern Rheumatology　33　(6)　2023/11/01

DOI： 10.1093/mr/roac129 　

ISSN： 1439-7609 1439-7595
SAPHO syndrome complicated by hypertrophic pachymeningitis

Yu Mori, Takuya Izumiyama, Ryuichi Kanabuchi, Toshimi Aizawa

International Journal of Rheumatic Diseases　2023/10/06
Publisher: Wiley
DOI： 10.1111/1756-185x.14937 　

ISSN： 1756-1841

eISSN： 1756-185X
Pyoderma gangrenosum after surgery for forefoot deformity in a patient with rheumatoid arthritis: a case report. International-journal

Yu Mori, Takuya Izumiyama, Kazuaki Otsuka, Ryuichi Kanabuchi, Jun Yamamoto, Mana Sekine, Naoko Mori, Yoshihide Asano, Toshimi Aizawa

Modern rheumatology case reports　2023/08/28

DOI： 10.1093/mrcr/rxad051 　

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Pyoderma gangrenosum (PG) is a rare inflammatory skin disease characterized by skin ulcers that are associated with autoimmune diseases. Although the effectiveness of immunosuppression with glucocorticoids and tumor necrosis factor inhibitors in treating PG has been reported, the utility of negative-pressure wound therapy (NPWT) for severe ulcerative lesions in patients with PG remains controversial. Herein, we report the case of a 76-year-old woman with rheumatoid arthritis who developed PG after undergoing surgery for a forefoot deformity. The patient showed improvement in deep ulcer lesions through NPWT while receiving treatment with abatacept and systemic glucocorticoids. Subsequent topical glucocorticoid therapy led to the remission of the PG. This case suggests that NPWT, when used under immunosuppressive conditions, does not exacerbate the pathergy and may be beneficial for treating severe ulcerative PG.
Photoinduced properties of anodized Ti alloys for biomaterial applications

N. Masahashi, M. Hatakeyama, Y. Mori, H. Kurishima, H. Inoue, T. Mokudai, K. Ohmura, T. Aizawa, S. Hanada

Scientific Reports　13　(1)　2023/08/25
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-023-41189-z 　

eISSN： 2045-2322

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Abstract The photocatalytic properties of anodic oxides on a newly developed TiNbSn and commonly used Ti6Al4V alloys as biomaterials were investigated. The alloys were anodized in an electrolyte of sodium tartrate acid with H₂O₂ at a high voltage and the mechanism of the photocatalytic and antiviral activities was studied. The anodized TiNbSn and Ti6Al4V exhibited highly crystallized rutile TiO₂ and poorly crystallized anatase TiO₂, respectively. X-ray photoelectron spectroscopy analysis revealed the presence of oxides of the alloying elements in addition to TiO₂. The anodized TiNbSn exhibited higher activities than Ti6Al4V, and electron spin resonance spectra indicated that the number of hydroxyl radicals (⋅OH) generated from the anodized TiNbSn was higher than that from the anodized Ti6Al4V. The results can be explained by two possible mechanisms: the higher crystallinity of TiO₂ on TiNbSn than that on the Ti6Al4V reduces the number of charge recombination sites and generates abundant ⋅OH; charge separation in the anodic oxide on TiNbSn due to the electronic band structure between TiO₂ and the oxides of alloying elements enhances photo activities. The excellent photoinduced characteristics of the anodized TiNbSn are expected to contribute to the safe and reliable implant treatment.
Assessment of clinical and radiological characteristics of Japanese patients with SAPHO syndrome

Yu Mori, Takuya Izumiyama, Hiroshi Okuno, Munenori Watanuki, Ryuichi Kanabuchi, Shinichiro Yoshida, Jun Iwatsu, Naoko Mori, Toshimi Aizawa

Modern Rheumatology　2023/08/24
Publisher: Oxford University Press (OUP)
DOI： 10.1093/mr/road086 　

ISSN： 1439-7595

eISSN： 1439-7609

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Abstract Objective This study aimed to analyse the radiological characteristics and clinical diversity of Japanese patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, a heterogeneous disorder. Methods Radiographs and clinical information from 115 Japanese patients (female/male: 81/34, mean age at onset: 48.7 years) diagnosed with SAPHO syndrome between January 2007 and December 2020 were retrospectively reviewed. Additionally, the treatment for SAPHO syndrome was explored. Results Among the 115 patients, 70 patients had complications, including palmoplantar pustulosis, acne, or psoriasis. Imaging studies included bone scintigraphy, magnetic resonance imaging, computed tomography, and positron emission tomography in 71, 58, 70, and 23 patients, respectively. The most frequent lesions were arthritis and hyperostosis of the sternoclavicular joints in 96 patients; spinal lesions, including sacroiliac arthritis were observed in 85 patients. Peripheral aseptic osteitis was observed in 22 patients, and the tibia was involved in 12. The treatments consisted of analgesics, bisphosphonates, conventional synthetic disease-modifying anti-rheumatic drugs, and biologics (tumour necrosis factor inhibitors and interleukin-23p19 inhibitors) in 85, 15, 23, and 10 patients (8 and 2 patients), respectively. Conclusion Sternoclavicular hyperostosis and pustulosis are frequently observed in patients with SAPHO syndrome. Biological agents were more frequently used in patients with peripheral osteitis and arthritis.
TiNbSn stems with gradient changes of Young’s modulus and stiffness reduce stress shielding compared to the standard fit-and-fill stems

Kazuyoshi Baba, Yu Mori, Daisuke Chiba, Yoshiyuki Kuwahara, Hiroaki Kurishima, Hidetatsu Tanaka, Atsushi Kogure, Masayuki Kamimura, Norikazu Yamada, Susumu Ohtsu, Masamizu Oyama, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

European Journal of Medical Research　28　(1)　2023/07/03
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s40001-023-01199-z 　

eISSN： 2047-783X

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Abstract Background The difference between Young’s moduli of the femur and the stem causes stress shielding (SS). TiNbSn (TNS) stem has a low Young’s modulus and strength with gradient functional properties during the change in elastic modulus with heat treatment. The aim of this study was to investigate the inhibitory effect of TNS stems on SS and their clinical outcomes compared to conventional stems. Methods This study was a clinical trial. Primary THA was performed using a TNS stem from April 2016 to September 2017 for patients in the TNS group. Unilateral THA was performed using a Ti6Al4V alloy stem from January 2007 to February 2011 for patients in the control group. The TNS and Ti6Al4V stems were matched in shape. Radiographs were obtained at the 1- and 3-year follow-ups. Two surgeons independently checked the SS grade and appearance of cortical hypertrophy (CH). The Japanese Orthopaedic Association (JOA) scores before and 1 year after surgery were assessed as clinical scores. Results None of the patients in the TNS group had grade 3 or 4 SS. In contrast, in the control group, 24% and 40% of patients had grade 3 and 4 SS at the 1- and 3-year follow-ups, respectively. The SS grade was lower in the TNS group than in the control group at the 1- and 3-year follow-ups (p < 0.001). The frequencies of CH in both groups were no significant difference at the 1- and 3-year follow-ups. The JOA scores of the TNS group significantly improved at 1 year after surgery and were comparable to control group. Conclusion The TNS stem reduced SS at 1 and 3 years after THA compared to the proximal-engaging cementless stem, although the shapes of the stems matched. The TNS stem could reduce SS, stem loosening, and periprosthetic fractures. Trial registration: Current Controlled Trials. ISRCTN21241251. https://www.isrctn.com/search?q=21241251. The date of registration was October 26, 2021. Retrospectively registered.
Radiologic-pathologic correlation should be considered to place the region of interest on the intravoxel incoherent motion imaging and diffusion kurtosis imaging maps

Mori, N., Mori, Y.

European Journal of Radiology　166　110975-110975　2023/07
Publisher: Elsevier {BV}
DOI： 10.1016/j.ejrad.2023.110975 　

ISSN： 1872-7727 0720-048X
Long-term results of Chiari pelvic osteotomy on the preservation of hip function with mean follow-up of more than 30 years and its prognostic factors

Hiroaki Kurishima, Daisuke Chiba, Kazuyoshi Baba, Soshi Hamada, Takayuki Suzuki, Ryuichi Kanabuchi, Genji Fujii, Masamizu Oyama, Tatsuhiro Ochiai, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Science　2023/06
Publisher: Elsevier BV
DOI： 10.1016/j.jos.2023.05.013 　

ISSN： 0949-2658
Impact of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite on Bone Repair in Refractory Bone Defects

Yu Mori, Ryo Hamai, Toshimi Aizawa, Osamu Suzuki

The Tohoku Journal of Experimental Medicine　2023/05
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2023.j040 　

ISSN： 0040-8727

eISSN： 1349-3329
Approaches to reduce periprosthetic bone resorption after total hip arthroplasty

Yu Mori, Naoko Mori

Journal of Bone and Mineral Metabolism　2023/04/08
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00774-023-01423-0 　

ISSN： 0914-8779

eISSN： 1435-5604
Radiologist expertise and responsibilities for off-label use of Urografin before the change in indication by medical health insurance.

Eriko Okuyama, Masazumi Matsuda, Yu Mori, Naoko Mori

Japanese journal of radiology　2023/03/13

DOI： 10.1007/s11604-023-01404-3 　
Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway

Yu Mori, Kazuko Ueno, Daisuke Chiba, Ko Hashimoto, Yosuke Kawai, Kazuyoshi Baba, Hidetatsu Tanaka, Takashi Aki, Masanori Ogasawara, Naoto Shibasaki, Katsushi Tokunaga, Toshimi Aizawa, Masao Nagasaki

International Journal of Molecular Sciences　24　(5)　5019-5019　2023/03/06
Publisher: MDPI AG
DOI： 10.3390/ijms24055019 　

eISSN： 1422-0067

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This study examined the association between developmental dysplasia of the hip (DDH) and disease-associated loci in a Japanese cohort. A genome-wide association study (GWAS) of 238 Japanese patients with DDH and 2044 healthy individuals was performed. As a replicate, GWAS was also conducted on the UK Biobank data with 3315 cases and matched 74,038 controls. Gene set enrichment analyses (GSEAs) of both the genetics and transcriptome of DDH were performed. Transcriptome analysis of cartilage specimens from DDH-associated osteoarthritis and femoral neck fractures was performed as a control. Most of the lead variants were very low-frequency ones in the UK, and variants in the Japanese GWAS could not be replicated with the UK GWAS. We assigned DDH-related candidate variants to 42 and 81 genes from the Japanese and UK GWASs, respectively, using functional mapping and annotation. GSEA of gene ontology, disease ontology, and canonical pathways identified the most enriched pathway to be the ferroptosis signaling pathway, both in the Japanese gene set as well as the Japanese and UK merged set. Transcriptome GSEA also identified significant downregulation of genes in the ferroptosis signaling pathway. Thus, the ferroptosis signaling pathway may be associated with the pathogenic mechanism of DDH.
Effect of vitamin D administration on muscle function improvement depending on vitamin D sufficiency status

Mori, Y., Mori, N.

Journal of Bone and Mineral Metabolism　41　(2)　2023/03
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00774-022-01394-8 　

ISSN： 1435-5604 0914-8779

eISSN： 1435-5604
Antimicrobial Properties of TiNbSn Alloys Anodized in a Sulfuric Acid Electrolyte

Mori, Y., Fujimori, S., Kurishima, H., Inoue, H., Ishii, K., Kubota, M., Kawakami, K., Mori, N., Aizawa, T., Masahashi, N.

Materials　16　(4)　1487-1487　2023/02/10
Publisher: MDPI AG
DOI： 10.3390/ma16041487 　

ISSN： 1996-1944

eISSN： 1996-1944
Letter to the Editor Regarding “Comparison of Efficacy of Percutaneous Vertebroplasty Versus Percutaneous Kyphoplasty in the Treatment of Osteoporotic Vertebral Asymmetric Compression Fracture”

Mori, Y., Mori, N.

World Neurosurgery　170　256-256　2023/02
Publisher: Elsevier {BV}
DOI： 10.1016/j.wneu.2022.10.125 　

ISSN： 1878-8769 1878-8750
Dynamic contrast-enhanced MRI could assess the local disease activity of enthesitis and dactylitis in patients with spondyloarthritis

Yu Mori, Naoko Mori

Skeletal Radiology　2023/01/10
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00256-023-04276-w 　

ISSN： 0364-2348

eISSN： 1432-2161
Low Young's Modulus TiNbSn Alloy Locking Plates Accelerate Osteosynthesis in Rabbit Tibiae

Masashi Koguchi, Yu Mori, Masayuki Kamimura, Kentaro Ito, Hidetatsu Tanaka, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

The Tohoku Journal of Experimental Medicine　2023
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2023.j075 　

ISSN： 0040-8727

eISSN： 1349-3329
Two-stage revision knee arthroplasty for metallosis in a patient with rheumatoid arthritis: A case report

Koyama, T., Mori, Y., Kamimura, M., Aki, T., Izumiyama, T., Mori, N., Chiba, D., Hashimoto, K., Yamamoto, N., Aizawa, T.

SAGE Open Medical Case Reports　11　2023/01

DOI： 10.1177/2050313X231177752 　

ISSN： 2050-313X
Feasibility of methotrexate discontinuation following tocilizumab and methotrexate combination therapy in patients with long-standing and advanced rheumatoid arthritis: a 3-year observational cohort study

Masayuki Miyata, Yasuhiko Hirabayashi, Yasuhiko Munakata, Yukitomo Urata, Koichi Saito, Hiroshi Okuno, Masaaki Yoshida, Takao Kodera, Ryu Watanabe, Seiya Miyamoto, Tomonori Ishii, Shigeshi Nakazawa, Hiromitsu Takemori, Takanobu Ando, Takashi Kanno, Masataka Komagamine, Ichiro Kato, Yuichi Takahashi, Atsushi Komatsuda, Kojiro Endo, Chihiro Murai, Yuya Takakubo, Takao Miura, Yukio Sato, Kazunobu Ichikawa, Tsuneo Konta, Noriyuki Chiba, Tai Muryoi, Hiroko Kobayashi, Hiroshi Fujii, Yukio Sekiguchi, Akira Hatakeyama, Ken Ogura, Hirotake Sakuraba, Tomoyuki Asano, Hiroshi Kanazawa, Eiji Suzuki, Satoshi Takasaki, Kenichi Asakura, Yoko Suzuki, Michiaki Takagi, Takahiro Nakayama, Hiroshi Watanabe, Keiki Miura, Yu Mori

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE　2023

DOI： 10.5387/fms.2022-06 　

ISSN： 0016-2590

eISSN： 2185-4610
How much force is acting on the shoulder joint to create a Hill-Sachs Lesion or reverse Hill-Sachs Lesion?

Etoh, T., Yamamoto, N., Kawakami, J., Kamimura, M., Chiba, D., Mori, Y., Hashimoto, K., Aizawa, T., Itoi, E.

Journal of Orthopaedic Science　28　(6)　2023
Publisher: Elsevier {BV}
DOI： 10.1016/j.jos.2022.09.016 　

ISSN： 1436-2023 0949-2658
Five cases of seronegative persistent inflammatory monoarthritis improved with biological therapy

Izumiyama, T., Mori, Y., Hamada, S., Kurishima, H., Mori, N., Aizawa, T.

Modern Rheumatology Case Reports　7　(1)　2023
Publisher: Oxford University Press (OUP)
DOI： 10.1093/mrcr/rxac063 　

ISSN： 2472-5625

eISSN： 2472-5625
A modified minimally invasive surgery for thoracic pyogenic spondylitis: Percutaneous pedicle screw fixation in combination with a vertebral debridement in a separate posterolateral approach—A case report

Yuki Sato, Ko Hashimoto, Michiharu Matsuda, Takahiro Onoki, Masayuki Kamimura, Kohei Takahashi, Yoshito Onoda, Daisuke Chiba, Yu Mori, Haruo Kanno, Nobuyuki Yamamoto, Toshimi Aizawa

Clinical Case Reports　10　(12)　2022/12
Publisher: Wiley
DOI： 10.1002/ccr3.6710 　

ISSN： 2050-0904

eISSN： 2050-0904
Impacts of external rotators and the ischiofemoral ligament on preventing excessive internal hip rotation: a cadaveric study

Baba, K., Chiba, D., Mori, Y., Kuwahara, Y., Kogure, A., Sugaya, T., Kamata, K., Oizumi, I., Suzuki, T., Kurishima, H., Hamada, S., Itoi, E., Aizawa, T.

Journal of Orthopaedic Surgery and Research　17　(1)　2022/12
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1186/s13018-021-02873-w 　

ISSN： 1749-799X
Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF-kB/MAPK signaling. International-journal

Mei-Tzu Su, Ono K, Kezuka D, Miyamoto S, Yu Mori, Toshiyuki Takai

International immunology　2022/11/04

DOI： 10.1093/intimm/dxac051 　

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Dysregulation of osteoclasts, the multinucleated cells responsible for bone resorption, contributes to several degenerative bone disorders. Previously, we showed that blocking the leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4), a kind of inhibitory receptor that plays an important role in immune regulation, promotes osteoclast differentiation in vitro. Here, we explored whether gp49B, the murine ortholog of LILRB4, regulates osteoclastogenesis in vivo, and whether fibronectin (FN), a ligand of LILRB4/gp49B, certainly contributes to LILRB4/gp49B-mediated osteoclastogenesis. In comparison with wild-type mice, gp49B deficiency mice exhibited a loss of trabecular bone number and an increase in osteoclast formation. Gp49B knockout improved the bone resorptive capacity of osteoclasts derived from murine Raw264.7 cells by increasing osteoclast formation. We further revealed that gp49B deficiency increased the receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced signaling transduction by increasing the phosphorylation of TGF-activated kinase 1 (TAK1), NF-κB and mitogen-activated protein kinases (MAPKs). Furthermore, the N-terminal 30 kDa proteolytic fragments of FN promoted gp49B-mediated inhibition of osteoclastogenesis by increasing Src homology-2-containing tyrosine phosphatase 1 (SHP-1) phosphorylation and tumor necrosis factor receptor-associated factor 6 (TRAF6)-SHP-1 association. In summary, the FN-LILRB4/gp49B interaction negatively regulates RANKL-induced TRAF6/TAK1/NF-𝜅B/MAPK signaling in osteoclastogenesis.
Letter to the Editor: Development of image analysis methods that reflect muscle weakness and fall risk

Yu Mori, Naoko Mori

Skeletal Radiology　52　(1)　57-58　2022/10/05
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00256-022-04200-8 　

ISSN： 0364-2348

eISSN： 1432-2161
Octacalcium Phosphate/Gelatin Composite (OCP/Gel) Enhances Bone Repair in a Critical-sized Transcortical Femoral Defect Rat Model

Soshi Hamada, Yu Mori, Yukari Shiwaku, Ryo Hamai, Kaori Tsuchiya, Kazuyoshi Baba, Itsuki Oizumi, Ryuichi Kanabuchi, Naohisa Miyatake, Toshimi Aizawa, Osamu Suzuki

Clinical Orthopaedics & Related Research　Publish Ahead of Print　(10)　2043-2055　2022/10
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/CORR.0000000000002257 　

ISSN： 0009-921X 1528-1132

eISSN： 1528-1132
β-type TiNbSn Alloy Plates With Low Young Modulus Accelerates Osteosynthesis in Rabbit Tibiae

Kentaro Ito, Yu Mori, Masayuki Kamimura, Masashi Koguchi, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

Clinical Orthopaedics & Related Research　480　(9)　1817-1832　2022/09
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/corr.0000000000002240 　

ISSN： 0009-921X

eISSN： 1528-1132
A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants

Yu Mori, Naoya Masahashi, Toshimi Aizawa

Materials　15　(15)　5116-5116　2022/07/22
Publisher: MDPI AG
DOI： 10.3390/ma15155116 　

eISSN： 1996-1944

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Titanium alloys are useful for application in orthopedic implants. However, complications, such as prosthetic infections and aseptic loosening, often occur after orthopedic devices are implanted. Therefore, innovation in surface modification techniques is essential to develop orthopedic materials with optimal properties at the biomaterial–bone interface. In this review, we present recent research on the improvement in the osteoconductivity and antibacterial effect of the Ti-33.6% Nb-4% Sn (TiNbSn) alloy by anodic oxidation and other related studies. TiNbSn alloys are excellent new titanium alloys with a low Young’s modulus, high tensile strength, and with gradient functional properties such as a thermally adjustable Young’s modulus and strength. Titanium dioxide (TiO2), when obtained by the anodic oxidation of a TiNbSn alloy, improves bone affinity and provides antibacterial performance owing to its photocatalytic activity. The safety of TiO2 and its strong bonding with metal materials make its method of preparation a promising alternative to conventional methods for improving the surface quality of orthopedic implants. Implementing anodization technology for TiNbSn alloys may alleviate orthopedic surgery-related complications, such as loosening, stress shielding, and infection after arthroplasty.
Improving osteoinductive properties and imparting antibacterial activity to titanium alloys

Yu Mori, Naoko Mori, Toshimi Aizawa

Journal of Bone and Mineral Metabolism　40　(4)　720-721　2022/06/01
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1007/s00774-022-01335-5 　

ISSN： 0914-8779 1435-5604

eISSN： 1435-5604
Evaluation of the usefulness of the Synovasure alpha-defensin lateral flow test kit for the diagnosis of periprosthetic joint infection in Japanese patients

Yu Mori, Ryuichi Kanabuchi, Kazayoshi Baba, Daisuke Chiba, Masayuki Kamimura, Naoko Mori, Toshimi Aizawa

Journal of Orthopaedic Science　27　(4)　935-938　2022/05
Publisher: Elsevier BV
DOI： 10.1016/j.jos.2022.05.001 　

ISSN： 0949-2658

eISSN： 1436-2023
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

Naoko Mori, Chihiro Inoue, Hajime Tamura, Tatsuo Nagasaka, Hainan Ren, Satoko Sato, Yu Mori, Minoru Miyashita, Shunji Mugikura, Kei Takase

Magnetic Resonance Imaging　90　53-60　2022/04/16
Publisher: Elsevier {BV}
DOI： 10.1016/j.mri.2022.04.003 　

ISSN： 0730-725X

eISSN： 1873-5894
Association between Hip Center Position and Isokinetic Hip Muscle Performance after Anterolateral Muscle-Sparing Total Hip Arthroplasty International-journal

Hidetatsu Tanaka, Norikazu Yamada, Hiroaki Kurishima, Yu Mori, Toshimi Aizawa

Medicina　58　(4)　538-538　2022/04/13
Publisher: MDPI AG
DOI： 10.3390/medicina58040538 　

ISSN： 1648-9144

eISSN： 1648-9144

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Background and objectives: The superior placement of the acetabular cup induced the delayed recovery of abductor muscle moment after total hip arthroplasty (THA) with a conventional posterior approach. The anterior-based muscle-sparing (ABMS) THA effectively reduces soft tissue damage, including muscles. The influence of hip center position on anterior-based muscle-sparing (ABMS) total hip arthroplasty (THA) for post-operative hip muscle strength was unclear. We evaluate whether the hip center position affects the recovery of hip muscle strength after ABMS THA. Materials and Methods: The study was performed as a retrospective cohort study, and included 38 hips in 38 patients that underwent primary ABMS THA. Muscle strength was measured using isokinetic dynamometry before the operation, and at 6 and 12 months after surgery. The horizontal and vertical centers of rotation (H-COR and V-COR), vertical shift (V-shift), leg length, and global femoral offset were determined radiographically in reference to a previous report. Results: A weak negative correlation was observed between abduction muscle strength at 6 months and V-shift; a V-shift more than 15 mm demonstrated significantly decreased abductor muscle strength at 6 months. Conclusions: The superior placement of the hip center caused delayed recovery of abductor muscle strength in hips with anterolateral minimally invasive THA. There seems to exist no biomechanical reason why the same should not also be the case for the muscle-sparing approach.
Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Hiroaki Kurishima, Yu Mori, Keiko Ishii, Hiroyuki Inoue, Takayuki Mokudai, Satoko Fujimori, Eiji Itoi, Shuji Hanada, Naoya Masahashi, Toshimi Aizawa

Frontiers in Bioengineering and Biotechnology　10　2022/04/11
Publisher: Frontiers Media {SA}
DOI： 10.3389/fbioe.2022.883335 　

ISSN： 2296-4185

eISSN： 2296-4185

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<jats:p>In this study, we anodized a TiNbSn alloy with low Young’s modulus in an electrolyte of sodium tartrate with and without hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>). The photo-induced characteristics of the anodized alloy were analyzed for crystallinity and electrochemical conditions with comparisons to the effect with the addition of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. The antibacterial activity was evaluated using methicillin-resistant <jats:italic>Staphylococcus aureus</jats:italic> and other pathogenic bacteria according to ISO 27447, and time decay antibacterial tests were also conducted. The anodized oxide had a porous microstructure with anatase- and rutile-structured titanium dioxide (TiO<jats:sub>2</jats:sub>). In contrast, the peaks of rutile-structured TiO<jats:sub>2</jats:sub> were accelerated in the anodized TiNbSn alloy with H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. The formation of hydroxyl radicals and methylene blue breaching performance under ultraviolet irradiation was confirmed in the anodic oxide on TiNbSn alloy with and without H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. The anodic oxide on TiNbSn alloy had a robust antibacterial activity, and no significant difference was detected with or without H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. We conclude that anodized TiNbSn alloy with sodium tartrate electrolyte may be a functional biomaterial with a low Young’s modulus and an antibacterial function.</jats:p>
Impacts of low molecular weight heparin on bone healing and osseointegration

Yu Mori, Toshimi Aizawa

Journal of Bone and Mineral Metabolism　2022/03
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1007/s00774-021-01290-7 　

ISSN： 0914-8779 1435-5604
Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation

Masaki Saito, Marina Hirano, Tomohiro Izumi, Yu Mori, Kentaro Ito, Yurika Saitoh, Nobuo Terada, Takeya Sato, Jun Sukegawa

International Journal of Molecular Sciences　23　(4)　2094-2094　2022/02
Publisher: {MDPI} {AG}
DOI： 10.3390/ijms23042094 　

ISSN： 1422-0067

eISSN： 1422-0067

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<jats:p>The primary cilium is a hair-like immotile organelle with specific membrane receptors, including the receptor of Hedgehog signaling, smoothened. The cilium organized in preosteoblasts promotes differentiation of the cells into osteoblasts (osteoblast differentiation) by mediating Hedgehog signaling to achieve bone formation. Notably, 4.1G is a plasma membrane-associated cytoskeletal protein that plays essential roles in various tissues, including the peripheral nervous system, testis, and retina. However, its function in the bone remains unexplored. In this study, we identified 4.1G expression in the bone. We found that, in the 4.1G-knockout mice, calcium deposits and primary cilium formation were suppressed in the trabecular bone, which is preosteoblast-rich region of the newborn tibia, indicating that 4.1G is a prerequisite for osteoblast differentiation by organizing the primary cilia in preosteoblasts. Next, we found that the primary cilium was elongated in the differentiating mouse preosteoblast cell line MC3T3-E1, whereas the knockdown of 4.1G suppressed its elongation. Moreover, 4.1G-knockdown suppressed the induction of the cilia-mediated Hedgehog signaling and subsequent osteoblast differentiation. These results demonstrate a new regulatory mechanism of 4.1G in bone formation that promotes the primary ciliogenesis in the differentiating preosteoblasts and induction of cilia-mediated osteoblast differentiation, resulting in bone formation at the newborn stage.</jats:p>
Rapid progression of joint deformity after subchondral insufficiency fracture of the knee with medial meniscal root tear

Yu Mori, Naoko Mori

Japanese Journal of Radiology　40　(7)　749-750　2022/01/30
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1007/s11604-022-01248-3 　

ISSN： 1867-1071 1867-108X

eISSN： 1867-108X
Mid-term results of a new femoral prosthesis using Ti-Nb-Sn alloy with low Young’s modulus

Daisuke Chiba, Norikazu Yamada, Yu Mori, Masamizu Oyama, Susumu Ohtsu, Yoshiyuki Kuwahara, Kazuyoshi Baba, Hidetatsu Tanaka, Toshimi Aizawa, Shuji Hanada, Eiji Itoi

BMC Musculoskeletal Disorders　22　(1)　2021/12
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1186/s12891-021-04879-1 　

ISSN： 1471-2474

eISSN： 1471-2474
Limited effects on patient outcomes of conjoint tendon release in anterolateral muscle-sparing total hip arthroplasty

Hidetatsu Tanaka, Norikazu Yamada, Hiroaki Kurishima, Yu Mori, Takashi Sakamoto, Masamizu Oyama, Toshimi Aizawa

Journal of Orthopaedic Surgery and Research　16　(1)　2021/12
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1186/s13018-021-02644-7 　

ISSN： 1749-799X

eISSN： 1749-799X
Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies

Yu Mori, Takuya Izumiyama, Hiroaki Kurishima, Masayuki Kamimura, Kazuyoshi Baba, Naoko Mori, Eiji Itoi

Journal of Orthopaedic Surgery and Research　16　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s13018-021-02271-2 　

eISSN： 1749-799X
Interstitial Lung Disease in a Woman with Rheumatoid Arthritis Treated with Denosumab: A Case Report

Yu Mori, Takuya Izumiyama, Naoko Mori, Toshimi Aizawa

Modern Rheumatology Case Reports　6　(2)　155-159　2021/11/17
Publisher: Oxford University Press ({OUP})
DOI： 10.1093/mrcr/rxab046 　

ISSN： 2472-5625

eISSN： 2472-5625
Quantitative parameters including volume of enhanced synovium and enhancement from the optimal scan timing might be needed for the assessment of treatment response in patients with rheumatoid arthritis

Mori, N., Mori, Y.

European Journal of Radiology　144　109998-109998　2021/11
Publisher: Elsevier BV
DOI： 10.1016/j.ejrad.2021.109998 　

ISSN： 1872-7727 0720-048X
Impacts of hydroxyvitamin D deficiency on impaired balance function and muscle weakness in young adults.

Yu Mori, Toshimi Aizawa

Journal of bone and mineral metabolism　39　(6)　1102　2021/08/23

DOI： 10.1007/s00774-021-01260-z 　

ISSN： 0914-8779

eISSN： 1435-5604
Clinical relevance of MR arthrography to classify the types of femoro-acetabular impingement

Yu Mori, Naoko Mori

Japanese Journal of Radiology　40　(2)　226-227　2021/08/10
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1007/s11604-021-01188-4 　

ISSN： 1867-108X

eISSN： 1867-108X
Mathematical model for histogram analysis of dynamic contrast-enhanced MRI: A method to evaluate the drug treatment response in rheumatoid arthritis

Yu Mori, Naoko Mori, Takuya Izumiyama, Asami Inoue, Kei Takase, Toshimi Aizawa

European Journal of Radiology　141　109831-109831　2021/08
Publisher: Elsevier BV
DOI： 10.1016/j.ejrad.2021.109831 　

ISSN： 0720-048X

eISSN： 1872-7727
Assessment of bone repair in animal models with suppressed osteoclast function by pretreatment of bisphosphonates

Yu Mori, Toshimi Aizawa

Journal of Bone and Mineral Metabolism　39　(6)　1101　2021/07/21
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1007/s00774-021-01251-0 　

ISSN： 1435-5604

eISSN： 1435-5604
The intraoperative hip range of motion in total hip arthroplasty predicts postoperative patient's satisfaction for cutting toenails and putting on sock

Hidetatsu Tanaka, Norikazu Yamada, Hiroaki Kurishima, Yu Mori, Takashi Sakamoto, Masamizu Oyama

Journal of Orthopaedic Science　2021/07
Publisher: Elsevier BV
DOI： 10.1016/j.jos.2021.06.005 　

ISSN： 0949-2658

eISSN： 1436-2023
Effect of interleukin-17A inhibitor in Japanese patients with psoriatic arthritis compared with tumor necrosis factor-alpha inhibitor

Takuya Izumiyama, Yu Mori, Itsuki Oizumi, Soshi Hamada, Hiroaki Kurishima, Hitoshi Terui, Ryoko Omori-Shimada, Kenshi Yamasaki, Eiji Itoi

Journal of Orthopaedic Surgery　29　(2)　230949902110122-230949902110122　2021/05/01
Publisher: SAGE Publications
DOI： 10.1177/23094990211012286 　

ISSN： 2309-4990

eISSN： 2309-4990
Discriminating low-grade ductal carcinoma in situ (DCIS) from non-low-grade DCIS or DCIS upgraded to invasive carcinoma: effective texture features on ultrafast dynamic contrast-enhanced magnetic resonance imaging

Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yo Oguma, Minami Hirasawa, Satoko Sato, Kei Takase

Breast Cancer　28　(5)　1141-1153　2021/04/26
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12282-021-01257-6 　

ISSN： 1340-6868

eISSN： 1880-4233
Photoactivity of an anodized biocompatible TiNbSn alloy prepared in sodium tartrate/hydrogen peroxide aqueous solution

N. Masahashi, Y. Mori, H. Kurishima, H. Inoue, T. Mokudai, S. Semboshi, M. Hatakeyama, E. Itoi, S. Hanada

Applied Surface Science　543　148829-148829　2021/03
Publisher: Elsevier {BV}
DOI： 10.1016/j.apsusc.2020.148829 　

ISSN： 0169-4332
Impact of simultaneous hydrolysis of OCP and PLGA on bone induction of a PLGA-OCP composite scaffold in a rat femoral defect

Itsuki Oizumi, Ryo Hamai, Yukari Shiwaku, Yu Mori, Takahisa Anada, Kazuyoshi Baba, Naohisa Miyatake, Soshi Hamada, Kaori Tsuchiya, Shin-nosuke Nishimura, Eiji Itoi, Osamu Suzuki

Acta Biomaterialia　124　358-373　2021/02
Publisher: Elsevier BV
DOI： 10.1016/j.actbio.2021.01.048 　

ISSN： 1742-7061

eISSN： 1878-7568
Acceleration of fracture healing in mouse tibiae using intramedullary nails composed of β-type tinbsn alloy with low young’s modulus

Yu Mori, Hirokazu Fujisawa, Masayuki Kamimura, Atsushi Kogure, Hidetatsu Tanaka, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

Tohoku Journal of Experimental Medicine　255　(2)　135-142　2021
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.255.135 　

ISSN： 0040-8727

eISSN： 1349-3329
The Effect of Teriparatide for the Treatment of Multiple Spontaneous Clinical Vertebral Fractures after Discontinuation of Denosumab in a Female Patient with Rheumatoid Arthritis: A Case Report

Yu Mori, Takuya Izumiyama, Naoko Mori, Toshimi Aizawa

The Tohoku Journal of Experimental Medicine　254　(1)　57-61　2021
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.254.57 　

ISSN： 0040-8727

eISSN： 1349-3329
Tocilizumab Was Effective in Repairing the Large Geode in a Patient with Rheumatoid Arthritis

Takuya Izumiyama, Yu Mori, Eiji Itoi

Case Reports in Rheumatology　2020　1-6　2020/08/25
Publisher: Hindawi Limited
DOI： 10.1155/2020/8899391 　

ISSN： 2090-6889

eISSN： 2090-6897

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Rheumatoid arthritis is characterized by multiple chronic arthritis subsequently inducing joint destruction. Although subchondral geode is a well-known feature of high-disease activity, a large geode is rare. Moreover, the treatment effect of biologic agents in the repair of large geode has not been reported. The present report shows the significant effect of interleukin-6 receptor blocker, tocilizumab, in repairing the large geode in the left humeral lateral epicondyle. This case implies that tocilizumab might be an effective treatment in patients with rheumatoid arthritis even with large geode.
Evaluation of risk factors of vertebral fracture in Japanese female patients with glucocorticoid-induced osteoporosis International-journal Peer-reviewed

Yu Mori, Takuya Izumiyama, Kazuyoshi Baba, Naoko Mori, Hiroshi Fujii, Tomonori Ishii, Eiji Itoi

Journal of Orthopaedic Surgery and Research　15　(1)　290-290　2020/07/29

DOI： 10.1186/s13018-020-01813-4 　

ISSN： 1749-799X

eISSN： 1749-799X
Psoriatic arthritis with skin lesions localized to the scalp: A case report Peer-reviewed

Tetsuya Akaishi, Kenshi Yamasaki, Yu Mori, Toshiya Takahashi, Takuya Izumiyama, Hitoshi Terui, Michiaki Abe, Shin Takayama, Setsuya Aiba, Tadashi Ishii

JOURNAL OF GENERAL AND FAMILY MEDICINE　21　(6)　264-267　2020/07

DOI： 10.1002/jgf2.358 　

ISSN： 2189-7948

eISSN： 2189-7948
Rheumatoid Arthritis After Cord Blood Cell Transplantation. International-journal Peer-reviewed

Tsuyoshi Shirai, Yu Mori, Takuya Izumiyama, Hiroshi Fujii, Tomonori Ishii, Hideo Harigae

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases　Publish Ahead of Print　(7)　e276-e277　2020/06/12
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/RHU.0000000000001430 　

ISSN： 1076-1608

eISSN： 1536-7355
Chemical Stability-Sensitive Osteoconductive Performance of Octacalcium Phosphate Bone Substitute in an Ovariectomized Rat Tibia Defect Peer-reviewed

Kazuyoshi Baba, Yukari Shiwaku, Ryo Hamai, Yu Mori, Takahisa Anada, Kaori Tsuchiya, Itsuki Oizumi, Naohisa Miyatake, Eiji Itoi, Osamu Suzuki

ACS Applied Bio Materials　3　(3)　1444-1458　2020/03/16

DOI： 10.1021/acsabm.9b01091 　

ISSN： 2576-6422

eISSN： 2576-6422
Turbo Spin-echo Diffusion-weighted Imaging Compared with Single-shot Echo-planar Diffusion-weighted Imaging: Image Quality and Diagnostic Performance When Differentiating between Ductal Carcinoma in situ and Invasive Ductal Carcinoma. Peer-reviewed

Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yui Maekawa, Tatsuo Nagasaka, Kei Takase

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　20　(1)　60-68　2020/03/06
Publisher: Japanese Society for Magnetic Resonance in Medicine
DOI： 10.2463/mrms.mp.2019-0195 　

ISSN： 1347-3182

eISSN： 1880-2206
Effect of eldecalcitol on muscle function and fall prevention in Japanese postmenopausal women: A randomized controlled trial Peer-reviewed

Takeshi Saito, Yu Mori, Osamu Irei, Kazuyoshi Baba, Satoru Nakajo, Eiji Itoi

Journal of Orthopaedic Science　26　(1)　173-178　2020

DOI： 10.1016/j.jos.2020.02.004 　

ISSN： 0949-2658

eISSN： 1436-2023
Validating an empirical mathematical model for dynamic contrast-enhanced MR imaging of hand and wrist synovitis in rheumatoid arthritis: Correlation of model parameters with clinical disease activity Peer-reviewed

Junko Ochi, Naoko Mori, Yu Mori, Shunji Mugikura, Shin Hitachi, Eiji Itoi, Kei Takase

Magnetic Resonance in Medical Sciences　19　(3)　176-183　2020

DOI： 10.2463/mrms.mp.2019-0026 　

ISSN： 1347-3182

eISSN： 1880-2206
Validating an empirical mathematical model for dynamic contrast-enhanced MR imaging of hand and wrist synovitis in rheumatoid arthritis: Correlation of model parameters with clinical disease activity Peer-reviewed

Ochi, J., Mori, N., Mori, Y., Mugikura, S., Hitachi, S., Itoi, E., Takase, K.

Magnetic Resonance in Medical Sciences　19　(3)　2020

DOI： 10.2463/mrms.mp.2019-0026 　

ISSN： 1880-2206
Improved Osseointegration of a TiNbSn Alloy with a Low Young’s Modulus Treated with Anodic Oxidation International-journal Peer-reviewed

Tomonori Kunii, Yu Mori, Hidetatsu Tanaka, Atsushi Kogure, Masayuki Kamimura, Naoko Mori, Shuji Hanada, Naoya Masahashi, Eiji Itoi

Scientific Reports　9　(1)　13985-13985　2019/12/01

DOI： 10.1038/s41598-019-50581-7 　

ISSN： 2045-2322

eISSN： 2045-2322
Meniscal tear morphology independently affects pain relief following arthroscopic partial meniscectomy in middle-aged patients International-journal Peer-reviewed

Masayuki Kamimura, Jutaro Umehara, Atsushi Takahashi, Yu Mori, Daisuke Chiba, Yoshiyuki Kuwahara, Eiji Itoi

Knee Surgery, Sports Traumatology, Arthroscopy　27　(8)　2460-2467　2019/08/01

DOI： 10.1007/s00167-018-5238-2 　

ISSN： 0942-2056

eISSN： 1433-7347
Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density International-journal Peer-reviewed

Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Chiaki Takasawa, Satoko Sato, Minoru Miyashita, Yu Mori, Federico D. Pineda, Gregory S. Karczmar, Hajime Tamura, Shoki Takahashi, Kei Takase

Academic Radiology　26　(7)　e141-e149　2019/07

DOI： 10.1016/j.acra.2018.08.016 　

ISSN： 1076-6332

eISSN： 1878-4046
The effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed destructive arthritis and enthesitis International-journal Peer-reviewed

Takuya Izumiyama, Yu Mori, Shiro Mori, Naoko Mori, Tetsuya Kodama, Eiji Itoi

BMC Musculoskeletal Disorders　20　(1)　286-286　2019/06/15

DOI： 10.1186/s12891-019-2664-3 　

ISSN： 1471-2474

eISSN： 1471-2474
Bioactive TiNbSn alloy prepared by anodization in sulfuric acid electrolytes Peer-reviewed

N. Masahashi, Y. Mori, H. Tanaka, A. Kogure, H. Inoue, K. Ohmura, Y. Kodama, M. Nishijima, E. Itoi, S. Hanada

Materials Science and Engineering C　98　753-763　2019/05
Publisher: Elsevier {BV}
DOI： 10.1016/j.msec.2019.01.033 　

ISSN： 0928-4931

eISSN： 1873-0191
Effects of elastic intramedullary nails composed of low Young's modulus Ti-Nb-Sn alloy on healing of tibial osteotomies in rabbits International-journal Peer-reviewed

Atsushi Kogure, Yu Mori, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi

Journal of Biomedical Materials Research - Part B Applied Biomaterials　107　(3)　700-707　2019/04

DOI： 10.1002/jbm.b.34163 　

ISSN： 1552-4973

eISSN： 1552-4981
Perfusion contrast-enhanced ultrasound to predict early lymph-node metastasis in breast cancer Peer-reviewed

Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yumiko Kudo, Mikiko Suzuki, Li Li, Yu Mori, Shoki Takahashi, Kei Takase

Japanese Journal of Radiology　37　(2)　145-153　2019/02/20

DOI： 10.1007/s11604-018-0792-6 　

ISSN： 1867-1071

eISSN： 1867-108X
Performance of an octacalcium phosphate biomaterial in a long bone defect in ovariectomized rat Peer-reviewed

Kazuyoshi Baba, Yukari Shiwaku, Takahisa Anada, Yu Mori, Kaori Tsuchiya, Eiji Itoi, Osamu Suzuki

Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium　40　932　2019

ISSN： 1526-7547
Effects of intramedullary nails composed of a new β-type Ti-Nb-Sn alloy with low Young's modulus on fracture healing in mouse tibiae International-journal Peer-reviewed

Hirokazu Fujisawa, Yu Mori, Atsushi Kogure, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi

Journal of Biomedical Materials Research - Part B Applied Biomaterials　106　(8)　2841-2848　2018/11

DOI： 10.1002/jbm.b.34064 　

ISSN： 1552-4973

eISSN： 1552-4981
Long-term results of a modified Spitzy shelf operation for developmental dysplasia of the hip in adults and adolescents International-journal Peer-reviewed

Hidetatsu Tanaka, Daisuke Chiba, Yu Mori, Yoshiyuki Kuwahara, Kazuyoshi Baba, Norikazu Yamada, Genji Fujii, Eiji Itoi

European Journal of Orthopaedic Surgery and Traumatology　28　(7)　1341-1347　2018/10/01

DOI： 10.1007/s00590-018-2191-1 　

ISSN： 1633-8065

eISSN： 1432-1068
Biomechanical analysis of supra-acetabular insufficiency fracture using finite element analysis Peer-reviewed

Hidetatsu Tanaka, Go Yamako, Hiroaki Kurishima, Shutaro Yamashita, Yu Mori, Daisuke Chiba, Etsuo Chosa, Eiji Itoi

Journal of Orthopaedic Science　23　(5)　825-833　2018/09

DOI： 10.1016/j.jos.2018.04.005 　

ISSN： 0949-2658

eISSN： 1436-2023
Clinical features and radiological findings of 67 patients with SAPHO syndrome International-journal Peer-reviewed

Hiroshi Okuno, Munenori Watanuki, Yoshiyuki Kuwahara, Akira Sekiguchi, Yu Mori, Shin Hitachi, Keiki Miura, Ken Ogura, Mika Watanabe, Masami Hosaka, Masahito Hatori, Eiji Itoi, Katsumi Sato

Modern Rheumatology　28　(4)　703-708　2018/07/04

DOI： 10.1080/14397595.2017.1372874 　

ISSN： 1439-7595

eISSN： 1439-7609
Assessment of the risk of low bone mineral density in premenopausal Japanese female patients with systemic lupus erythematosus International-journal Peer-reviewed

Yu Mori, Kazuyoshi Baba, Atsushi Kogure, Takuya Izumiyama, Michiharu Matsuda, Naoko Mori, Tomonori Ishii, Eiji Itoi

Journal of Orthopaedics　15　(1)　89-93　2018/03

DOI： 10.1016/j.jor.2018.01.029 　

ISSN： 0972-978X

eISSN： 0972-978X
Study of bioactivity on a TiNbSn alloy surface Peer-reviewed

N. Masahashi, Y. Mori, H. Tanaka, A. Kogure, H. Inoue, K. Ohmura, Y. Kodama, M. Nishijima, E. Itoi, S. Hanada

Thin Solid Films　639　22-28　2017/10/01

DOI： 10.1016/j.tsf.2017.08.023 　

ISSN： 0040-6090
Posture analysis in patients with spinal osteoporosis Peer-reviewed

Eiji Itoi, Yu Mori

Non-Pharmacological Management of Osteoporosis: Exercise, Nutrition, Fall and Fracture Prevention　31-43　2017/06/06
Publisher: Non-Pharmacological Management of Osteoporosis: Exercise, Nutrition, Fall and Fracture Prevention
DOI： 10.1007/978-3-319-54016-0_3 　
A vitamin D analogue, eldecalcitol, enhances expression of fast myosin heavy chain subtypes in differentiated C2C12 myoblasts Peer-reviewed

Hideo Saito, Koshi N. Kishimoto, Yu Mori, Hiroshi Okuno, Masahiko Tanaka, Eiji Itoi

Journal of Orthopaedic Science　22　(2)　345-350　2017/03/01

DOI： 10.1016/j.jos.2016.12.005 　

ISSN： 0949-2658

eISSN： 1436-2023
Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging in Invasive Breast Cancer: A Novel Technique to Obtain Histopathologic Information of Microvessel Density International-journal Peer-reviewed

Naoko Mori, Shunji Mugikura, Shoki Takahashi, Koichi Ito, Chiaki Takasawa, Li Li, Minoru Miyashita, Atsuko Kasajima, Yu Mori, Takanori Ishida, Tetsuya Kodama, Kei Takase

Ultrasound in Medicine and Biology　43　(3)　607-614　2017/03/01

DOI： 10.1016/j.ultrasmedbio.2016.11.009 　

ISSN： 0301-5629

eISSN： 1879-291X
Is Methotrexate (MTX) Necessary in Combination Therapy with Tocilizumab and MTX for Rheumatoid Arthritis in Remission? Cohort Study Carried by the Michinoku Tocilizumab Study Group

Masayuki Miyata, Yasuhiko Hirabayashi, Yasuhiko Munakata, Yukitomo Urata, Koichi Saito, Hiroshi Okuno, Masaki Yoshida, Takao Koderai, Ryu Watanabei, Seiya Miyamoto, Tomonori Ishii, Shigeshi Nakazawa, Hiromitsu Takemori, Takanobu Ando, Takashi Kanno, Masataka Komagamine, Ichiro Kato, Yuichi Takahashi, Atsushi Komatsuda, Kojiro Endo, Chihiro Murai, Yuya Takakubo, Takao Miura, Yukio Sato, Kazunobu Ichikawa, Tsuneo Konta, Noriyuki Chiba, Tai Muryoi, Hiroko Kobayashi, Hiroshi Fujii, Yukio Sekiguchi, Akira Hatakeyama, Ken Ogura, Hirotake Sakuraba, Tomoyuki Asano, Hiroshi Kanazawa, Eiji Suzuki, Satoshi Takasaki, Kenichi Asakura, Yoko Suzuki, Michiaki Takagi, Takahiro Nakayama, Hiroshi Watanabe, Keiki Miura, Yu Mori

Internal Medicine: Open Access　07　(02)　2017
Publisher: OMICS Publishing Group
DOI： 10.4172/2165-8048.1000240 　

ISSN： 2165-8048

eISSN： 2165-8048
Bone mineral density of postmenopausal women with rheumatoid arthritis depends on disease duration regardless of treatment Peer-reviewed

Yu Mori, Yoshiyuki Kuwahara, Shinpei Chiba, Atsushi Kogre, Kazuyoshi Baba, Masayuki Kamimura, Eiji Itoi

Journal of Bone and Mineral Metabolism　35　(1)　52-57　2017/01/01

DOI： 10.1007/s00774-015-0716-9 　

ISSN： 0914-8779

eISSN： 1435-5604
Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3–green fluorescent protein reporter mice Peer-reviewed

Yu Mori, Douglas Adams, Yusuke Hagiwara, Ryu Yoshida, Masayuki Kamimura, Eiji Itoi, David W. Rowe

Journal of Bone and Mineral Metabolism　34　(6)　606-614　2016/11/01

DOI： 10.1007/s00774-015-0711-1 　

ISSN： 0914-8779

eISSN： 1435-5604
Clinical and structural remission rates increased annually and radiographic progression was continuously inhibited during a 3-year administration of tocilizumab in patients with rheumatoid arthritis: A multi-center, prospective cohort study by the Michinoku Tocilizumab Study Group International-journal Peer-reviewed

Yasuhiko Hirabayashi, Yasuhiko Munakata, Masayuki Miyata, Yukitomo Urata, Koichi Saito, Hiroshi Okuno, Masaaki Yoshida, Takao Kodera, Ryu Watanabe, Seiya Miyamoto, Tomonori Ishii, Shigeshi Nakazawa, Hiromitsu Takemori, Takanobu Ando, Takashi Kanno, Masataka Komagamine, Ichiro Kato, Yuichi Takahashi, Atsushi Komatsuda, Kojiro Endo, Chihiro Murai, Yuya Takakubo, Takao Miura, Yukio Sato, Kazunobu Ichikawa, Tsuneo Konta, Noriyuki Chiba, Tai Muryoi, Hiroko Kobayashi, Hiroshi Fujii, Yukio Sekiguchi, Akira Hatakeyama, Ken Ogura, Hirotake Sakuraba, Tomoyuki Asano, Hiroshi Kanazawa, Eiji Suzuki, Satoshi Takasaki, Kenichi Asakura, Kota Sugisaki, Yoko Suzuki, Michiaki Takagi, Takahiro Nakayama, Hiroshi Watanabe, Keiki Miura, Yu Mori, Hideo Harigae, Satoshi Hoshi, Ryo Ichinohasama, Yoh Ishiguro, Eiji Itoi, Nobuki Maki, Takatomo Moro, Hiromasa Ohira, Naohisa Ouchi, Yuta Oyama, Akira Rikimaru, Souichi Saito, Akiko Sasaki, Takeshi Sasaki, Akira Sekiguchi, Tadashi Shimamura, Mikio Suzuki, Yuji Wakai, Seiji Yamaya

Modern Rheumatology　26　(6)　828-835　2016/11/01

DOI： 10.3109/14397595.2016.1160991 　

ISSN： 1439-7595

eISSN： 1439-7609
Prediction of pathological fracture of the femoral shaft with an osteolytic lesion using a computed tomography-based nonlinear three-dimensional finite element method Peer-reviewed

Daisuke Chiba, Yu Mori, Hirotaka Sano, Koshi Kishimoto, Masahito Hatori, Atsushi Takahashi, Satoru Nakajo, Eiji Itoi

Journal of Orthopaedic Science　21　(4)　530-538　2016/07/01

DOI： 10.1016/j.jos.2016.04.003 　

ISSN： 0949-2658

eISSN： 1436-2023
Apatite formation and biocompatibility of a low young's modulus Ti-Nb-Sn alloy treated with anodic oxidation and hot water International-journal Peer-reviewed

Hidetatsu Tanaka, Yu Mori, Atsushi Noro, Atsushi Kogure, Masayuki Kamimura, Norikazu Yamada, Shuji Hanada, Naoya Masahashi, Eiji Itoi

PLoS ONE　11　(2)　e0150081　2016/02

DOI： 10.1371/journal.pone.0150081 　

ISSN： 1932-6203

eISSN： 1932-6203
Impaired fracture healing caused by deficiency of the immunoreceptor adaptor protein DAP12 International-journal Peer-reviewed

Masayuki Kamimura, Yu Mori, Akiko Sugahara-Tobinai, Toshiyuki Takai, Eiji Itoi

PLoS ONE　10　(6)　e0128210　2015/06/01

DOI： 10.1371/journal.pone.0128210 　

ISSN： 1932-6203

eISSN： 1932-6203
Efficacy of methotrexate and tumor necrosis factor inhibitors in Japanese patients with active psoriatic arthritis International-journal Peer-reviewed

Yu Mori, Yoshiyuki Kuwahara, Shinpei Chiba, Eiji Itoi

Modern Rheumatology　25　(3)　431-434　2015

DOI： 10.3109/14397595.2014.958891 　

ISSN： 1439-7595

eISSN： 1439-7609
Risk of acetabular protrusion is low in rheumatoid arthritis patients treated with bipolar hemiarthroplasty for displaced femoral neck fractures without rheumatoid change in hip joints International-journal Peer-reviewed

Yu Mori, Naoko Mori, Taketo Mori, Satoshi Nakamura, Masato Ishizuka, Tokuhisa Sano, Eiji Itoi

European Journal of Orthopaedic Surgery and Traumatology　24　(6)　905-909　2014/08

DOI： 10.1007/s00590-013-1379-7 　

ISSN： 1633-8065

eISSN： 1432-1068
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development International-journal Peer-reviewed

Yu Mori, Sukenao Tsuji, Masanori Inui, Yuzuru Sakamoto, Shota Endo, Yumi Ito, Shion Fujimura, Takako Koga, Akira Nakamura, Hiroshi Takayanagi, Eiji Itoi, Toshiyuki Takai

Journal of Immunology　181　(7)　4742-4751　2008/10/01

DOI： 10.4049/jimmunol.181.7.4742 　

ISSN： 0022-1767

eISSN： 1550-6606
[Regulatory mechanisms of osteoclast development and bone disorders]. Peer-reviewed

Masanori Inui, Yu Mori, Toshiyuki Takai

Seikagaku. The Journal of Japanese Biochemical Society　78　(3)　250-6　2006/03

ISSN： 0037-1017

Show all ︎Show first 5

Misc. 150

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Type C1およびC2の大腿骨頭壊死症患者の寛骨臼形態が骨頭圧壊と股関節機能に与える影響に関する後ろ向き調査

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eISSN： 2758-7479
体軸性脊椎関節炎患者における脊椎病変進行関連因子の解明

泉山拓也, 森優, 金淵龍一, 相澤俊峰

日本整形外科学会雑誌　98　(3)　S1270-S1270　2024/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325

eISSN： 2758-7479
Investigation of antimicrobial effect of anodized TiNbSn alloy

森優, 正橋直哉

東北大学金属材料研究所新素材共同研究開発センター共同利用研究報告書(CD-ROM)　2023　2024
Pathophysiology and treatment strategies for secondary osteoporosis

森優

骨折(Web)　46　(Supplement (CD-ROM))　2024

ISSN： 2434-6055
Stage1・2の大腿骨頭壊死患者の骨形態と骨頭圧潰に関する後ろ向き調査

栗山恭明, 田中秀達, 馬場一慈, 金淵龍一, 森優, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　51st　2024
人工股関節全置換術術前の骨粗鬆症治療導入が術後成績に与える影響

金淵龍一, 森優, 馬場一慈, 田中秀達, 栗山恭明, 畠山拡, 川又裕輝, 福地英輝, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　51st　2024
腸骨大腿靭帯を含む股関節包切開方向が股関節安定性に与える影響の検討-新鮮凍結屍体を用いて

田中秀達, 馬場一慈, 金淵龍一, 栗山恭明, 森優, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　51st　2024
骨折の有無で比較検討した骨粗鬆症治療中の関節リウマチ患者の特徴

泉山拓也, 森優, 金淵龍一, 相澤俊峰

日本骨粗鬆症学会雑誌　10　(Suppl.1 (CD-ROM))　2024

ISSN： 2189-8383
リン酸八カルシウム(OCP)骨補填材の開発と生体材料としての特徴について

鈴木治, 森優, 濱井瞭, 酒井進, 土屋香織, 相澤俊峰

整形外科バイオマテリアル研究会プログラム・抄録集　43rd　2024
陽極酸化TiO₂の光触媒活性に及ぼす基板依存性

正橋直哉, 久保田真彩, 目代貴之, 森優, 栗島宏明, 井上博之, 相澤俊峰, 花田修治

日本金属学会講演大会(Web)　174th　2024
陰圧閉鎖療法で著明な改善を得た、足趾形成術後に壊疽性膿皮症を発症した関節リウマチの1例

泉山拓也, 森優, 相澤俊峰

日本足の外科学会雑誌　44　(Suppl.)　S418-S418　2023/10
Publisher: (一社)日本足の外科学会
ISSN： 0916-7927
ラット大腿骨皮質骨欠損におけるOCP/Gel,Gel,β-TCPの骨修復能の検討

森優, 金淵龍一, 濱井瞭, 土屋香織, 馬場一慈, 濱田壮志, 相澤俊峰, 鈴木治

日本バイオマテリアル学会大会予稿集　45回　143-143　2023/10
Publisher: 日本バイオマテリアル学会
ケモカイン担持リン酸八カルシウムのラット長管骨欠損修復能の評価

金淵龍一, 濱井瞭, 塩飽由香利, 森優, 土屋香織, 蔡優広, 濱田壮志, 栗山恭明, 原田健登, 相澤俊峰, 鈴木治

日本バイオマテリアル学会大会予稿集　45回　270-270　2023/10
Publisher: 日本バイオマテリアル学会
Baricitinibの特徴とこれからの関節リウマチ治療で求められる役割

森優

日本足の外科学会雑誌　44　(Suppl.)　S188-S188　2023/10
Publisher: (一社)日本足の外科学会
ISSN： 0916-7927
リン酸オクタカルシウム/ゼラチン多孔質複合体のラット大腿骨両側皮質骨欠損モデルに対する骨修復能の放射線学的・組織学的評価

金淵龍一, 森優, 濱井瞭, 土屋香織, 宮武尚史, 馬場一慈, 濱田壮志, 栗山恭明, 原田健登, 相澤俊峰, 鈴木治

日本整形外科学会雑誌　97　(8)　S1617-S1617　2023/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
人工股関節全置換術前の口腔ケアは全例で必要か? 口腔ケアが必要な感染高リスク症例の抽出法の検討

馬塲一慈, 千葉大介, 森優, 金淵龍一, 栗山恭明, 栗島宏明, 鈴木貴之, 濱田壮志, 相澤俊峰

Hip Joint　49　(1)　57-59　2023/08
Publisher: 日本股関節学会
ISSN： 0389-3634
PJI 人工関節周囲感染診断におけるalpha-defensin検査の有用性について

森優, 千葉大介, 上村雅之, 金淵龍一, 馬場一慈, 相澤俊峰

日本骨・関節感染症学会プログラム・抄録集　46回　108-108　2023/06
Publisher: (一社)日本骨・関節感染症学会
整形外科医による関節リウマチの治療戦略

森優

日本関節病学会誌　42　(3)　251-251　2023/06
Publisher: (一社)日本関節病学会
ISSN： 1883-2873

eISSN： 1884-9067
【人工関節における進歩】バイオマテリアル金属素材と表面加工チタン合金・低弾性チタン合金低弾性チタン合金,チタン-ニオブ-スズ合金で開発した人工股関節ステムの成績と今後の展望

千葉大介, 山田則一, 森優, 馬場一慈, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

別冊整形外科　(83)　9-12　2023/04
Publisher: (株)南江堂
ISSN： 0287-1645

eISSN： 2433-4316
脊椎関節炎-3 体軸性脊椎関節炎患者における脊椎病変進行の関連因子の解明

泉山拓也, 森優, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　67回　600-600　2023/03
Publisher: (一社)日本リウマチ学会
脊椎関節炎-3 SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　67回　600-600　2023/03
Publisher: (一社)日本リウマチ学会
関節症の評価と発症機序・病態日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 泉山拓也, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　67回　686-686　2023/03
Publisher: (一社)日本リウマチ学会
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 千葉大介, 橋本功, 馬場一慈, 田中秀達, 植野和子, 長崎正朗, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S115-S115　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
生物学的製剤使用下における,体軸性脊椎関節炎の脊椎強直進行因子の検討

泉山拓也, 森優, 栗山恭明, 金淵龍一, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S887-S887　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 綿貫宗則, 吉田新一郎, 森菜緒子, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S888-S888　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
新規に開発した同一stem内で剛性が変化するstem(TiNbSn stem)のstress shielding予防効果

馬場一慈, 千葉大介, 森優, 田中秀達, 小暮敦史, 桑原功行, 山田則一, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S1114-S1114　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 千葉大介, 橋本功, 馬場一慈, 田中秀達, 植野和子, 長崎正朗, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S115-S115　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎関節炎-3 体軸性脊椎関節炎患者における脊椎病変進行の関連因子の解明

泉山拓也, 森優, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　67回　600-600　2023/03
Publisher: (一社)日本リウマチ学会
脊椎関節炎-3 SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　67回　600-600　2023/03
Publisher: (一社)日本リウマチ学会
関節症の評価と発症機序・病態日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 泉山拓也, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　67回　686-686　2023/03
Publisher: (一社)日本リウマチ学会
生物学的製剤使用下における,体軸性脊椎関節炎の脊椎強直進行因子の検討

泉山拓也, 森優, 栗山恭明, 金淵龍一, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S887-S887　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 綿貫宗則, 吉田新一郎, 森菜緒子, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S888-S888　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
新規に開発した同一stem内で剛性が変化するstem(TiNbSn stem)のstress shielding予防効果

馬場一慈, 千葉大介, 森優, 田中秀達, 小暮敦史, 桑原功行, 山田則一, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S1114-S1114　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
整形外科医からみた脊椎関節炎の診断と治療

森優

日本脊椎関節炎学会誌(Web)　10　(Suppl)　2023

ISSN： 2435-6778
陽極酸化TiNbSn合金の光誘起特性

正橋直哉, 久保田真彩, 森優, 目代貴之, 井上博之, 花田修治

日本金属学会講演大会(Web)　173rd　2023
大腿骨転子部骨折の早期手術の有効性についての検討

田中秀達, 野呂篤司, 鯉淵迪子, 松本周, 伊東健太郎, 浜田壮志, 鈴木貴之, 杉村誠一, 森優, 相澤俊峰, 増田啓治

日本整形外科学会雑誌　97　(2)　2023

ISSN： 0021-5325
関節リウマチ患者における、前足部手術後の外反母趾再発に関わる因子の検討

泉山拓也, 森優, 相澤俊峰

日本足の外科学会雑誌　43　(Suppl.)　S284-S284　2022/10
Publisher: (一社)日本足の外科学会
ISSN： 0916-7927
関節リウマチ患者における、前足部手術後の外反母趾再発に関わる因子の検討

泉山拓也, 森優, 相澤俊峰

日本足の外科学会雑誌　43　(Suppl.)　S284-S284　2022/10
Publisher: (一社)日本足の外科学会
ISSN： 0916-7927
低弾性率チタン合金製ロッキングプレートによるウサギ脛骨骨切り部の骨癒合促進効果

古口昌志, 森優, 伊東健太郎, 古山和樹, 正橋直哉, 花田修二, 相澤俊峰

日本整形外科学会雑誌　96　(8)　S1644-S1644　2022/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
ステロイド性骨粗鬆症におけるロモソズマブの治療成績前治療薬による比較と導入前骨代謝マーカーから見た治療効果の予測

高橋忠久, 森優, 藤盛理子, 相澤俊峰

日本骨粗鬆症学会雑誌　8　(Suppl.1)　157-157　2022/08
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
【整形外科医×関節リウマチ診療今後の関わり方を考える】今後のリウマチ診療における整形外科リウマチ医の役割について

森優

臨床整形外科　57　(7)　847-851　2022/07
Publisher: (株)医学書院
ISSN： 0557-0433

eISSN： 1882-1286
リウマチ整形外科医の現状と未来～今後どのような方向へ向かうべきか?～関節リウマチ診療の課題と展望整形外科医の立場から

森優

日本リウマチ学会総会・学術集会プログラム・抄録集　66回　191-191　2022/03
Publisher: (一社)日本リウマチ学会
骨粗鬆症と骨代謝閉経後関節リウマチ患者におけるビスホスホネート製剤から切り替え後のデノスマブによる関節破壊防止効果

森優, 泉山拓也, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　66回　381-381　2022/03
Publisher: (一社)日本リウマチ学会
リウマチ性疾患における感染症人工関節周囲感染に対するalpha-defensin検出キットの有用性

金淵龍一, 森優, 泉山拓也

日本リウマチ学会総会・学術集会プログラム・抄録集　66回　462-462　2022/03
Publisher: (一社)日本リウマチ学会
ダイナミック造影MRIのヒストグラム解析の数理モデルによる関節リウマチの薬物治療効果判定の検討

森優, 泉山拓也, 相澤俊峰

日本整形外科学会雑誌　96　(2)　S434-S434　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
整形外科医からみた乾癬性関節炎の病態と治療

森優

日本整形外科学会雑誌　96　(3)　S552-S552　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
股関節内旋制動における外旋筋や後方関節包の機能が、股関節屈曲角度で異なるか Cadaverを用いた研究

馬場一慈, 千葉大介, 森優, 桑原功行, 小暮敦史, 菅谷岳広, 鈴木貴之, 栗島宏明, 浜田壮志, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S805-S805　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
閉経後関節リウマチ患者におけるビスフォスフォネート製剤から切り替え後のデノスマブによる関節破壊防止効果

森優, 泉山拓也, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S865-S865　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
リウマチ整形外科医の現状と未来〜今後どのような方向へ向かうべきか?〜関節リウマチ診療の課題と展望整形外科医の立場から

森優

日本リウマチ学会総会・学術集会プログラム・抄録集　66回　191-191　2022/03
Publisher: (一社)日本リウマチ学会
骨粗鬆症と骨代謝閉経後関節リウマチ患者におけるビスホスホネート製剤から切り替え後のデノスマブによる関節破壊防止効果

森優, 泉山拓也, 金淵龍一

日本リウマチ学会総会・学術集会プログラム・抄録集　66回　381-381　2022/03
Publisher: (一社)日本リウマチ学会
リウマチ性疾患における感染症人工関節周囲感染に対するalpha-defensin検出キットの有用性

金淵龍一, 森優, 泉山拓也

日本リウマチ学会総会・学術集会プログラム・抄録集　66回　462-462　2022/03
Publisher: (一社)日本リウマチ学会
関節リウマチ薬物治療効果判定に有効な手関節ダイナミックMRIのパラメータ検証

森菜緒子, 常陸真, 麦倉俊司, 高瀬圭, 森優, 井上麻美

Japanese Journal of Radiology　40　(Suppl.)　5-5　2022/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
人工股関節置換術の術中関節可動域と術後の靴下の着脱・爪切り動作の満足度についての検討

田中秀達, 田中秀達, 山田則一, 栗島宏明, 栗島宏明, 坂本敬, 森優, 大沼正宏, 大山正瑞, 相澤俊峰, 北純

日本整形外科学会雑誌　96　(3)　2022

ISSN： 0021-5325
Anterolateral supine approach(ALSA)-THAにおける内閉鎖筋共同腱の温存・解離の臨床的意義について-

田中秀達, 田中秀達, 山田則一, 栗島宏明, 栗島宏明, 坂本敬, 森優, 大沼正宏, 大山正瑞, 相澤俊峰, 北純

日本整形外科学会雑誌　96　(3)　2022

ISSN： 0021-5325
体軸性脊椎関節炎における単純レントゲン上での病変に対する生物学的製剤の効果検討

泉山拓也, 森優, 相澤俊峰

日本脊椎関節炎学会誌　9　(Suppl.)　S-68　2022
Publisher: 日本脊椎関節炎学会
eISSN： 2435-6778
体軸性脊椎関節炎における単純レントゲン上での病変に対する生物学的製剤の効果検討

泉山拓也, 森優, 相澤俊峰

日本脊椎関節炎学会誌　9　(Suppl.)　S-68　2022
Publisher: 日本脊椎関節炎学会
eISSN： 2435-6778
陽極酸化TiNbSn合金の光誘起機能

正橋直哉, 久保田真彩, 目代貴之, 森優, 栗島宏明, 井上博之, 相澤俊峰, 花田修治

日本金属学会講演大会(Web)　171st　2022
関節リウマチ治療におけるIL-6制御の意義

森優

日本リウマチ学会北海道・東北支部学術集会抄録集　31回　33-33　2022/01
Publisher: (一社)日本リウマチ学会-北海道・東北支部
メタローシスに対して二期的に人工膝関節再置換術を行った関節リウマチの一例

古山和樹, 森優, 上村雅之, 相澤俊峰

日本リウマチ学会北海道・東北支部学術集会抄録集　31回　56-56　2022/01
Publisher: (一社)日本リウマチ学会-北海道・東北支部
一次繊毛を介した骨芽細胞分化における膜裏打ちタンパク質4.1Gの役割

斎藤将樹, 泉朋宏, 森優, 齊藤百合花, 寺田信生

日本生化学会大会プログラム・講演要旨集　94回　[2T14a-611)]　2021/11
Publisher: (公社)日本生化学会
長期ステロイド性骨粗鬆症罹患症例における脆弱性骨折のリスク因子の評価

高橋忠久, 森優, 伊藤健太郎, 鈴木貴之, 佐藤宏陽, 相澤俊峰

日本骨粗鬆症学会雑誌　7　(Suppl.1)　302-302　2021/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
ステロイド性骨粗鬆症にロモソズマブを使用した6例

高橋忠久, 森優, 伊藤健太郎, 鈴木貴之, 佐藤宏陽, 相澤俊峰

日本骨粗鬆症学会雑誌　7　(Suppl.1)　303-303　2021/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
ビスフォスフォネートから治療変更したデノスマブの抗CCP抗体陽性関節リウマチ症例における骨関節破壊の抑制効果の検討

森優, 泉山拓也, 井樋栄二, 相澤俊峰

日本骨粗鬆症学会雑誌　7　(Suppl.1)　339-339　2021/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
酒石酸ナトリウム電解浴で陽極酸化したTNS合金の抗菌能

栗島宏明, 森優, 正橋直哉, 石井恵子, 井上博之, 畠山美樹, 花田修治, 川上和義, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　95　(8)　S1784-S1784　2021/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
低弾性率チタン合金製プレートによるウサギ脛骨骨切り部の骨癒合促進効果

伊東健太郎, 森優, 國井知典, 栗島宏明, 古口昌志, 藤盛理子, 正橋直哉, 花田修治, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　95　(8)　S1813-S1813　2021/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
生物学的製剤により改善を得られた、大関節関節炎を主とする血清反応陰性関節リウマチの5症例に関する検討

泉山拓也, 森優, 井樋栄二

日本リウマチ学会総会・学術集会プログラム・抄録集　65回　578-578　2021/03
Publisher: (一社)日本リウマチ学会
関節リウマチにおける薬物治療後の手指・手関節ダイナミックMRIの臨床的意義の検討

森優, 泉山拓也, 井樋栄二

日本リウマチ学会総会・学術集会プログラム・抄録集　65回　556-556　2021/03
Publisher: (一社)日本リウマチ学会
関節リウマチにおける薬物治療後の手指・手関節ダイナミックMRIの臨床的意義の検討

森優, 泉山拓也, 井樋栄二

日本リウマチ学会総会・学術集会プログラム・抄録集　65回　556-556　2021/03
Publisher: (一社)日本リウマチ学会
生物学的製剤により改善を得られた、大関節関節炎を主とする血清反応陰性関節リウマチの5症例に関する検討

泉山拓也, 森優, 井樋栄二

日本リウマチ学会総会・学術集会プログラム・抄録集　65回　578-578　2021/03
Publisher: (一社)日本リウマチ学会
ラット長管骨骨欠損モデルにおける新規骨補填材のリン酸八カルシウムと乳酸グリコール酸共重合体複合体による骨修復効果の検討

大泉樹, 森優, 塩飽由香利, 濱井瞭, 馬場一慈, 穴田貴久, 井樋栄二, 鈴木治

日本整形外科学会雑誌　94　(8)　S1917-S1917　2020/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
日本人ステロイド骨粗鬆症症例における椎体骨折の危険因子の検討

森優, 泉山拓也, 馬場一慈, 井樋栄二

日本骨粗鬆症学会雑誌　6　(Suppl.1)　310-310　2020/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
閉経後骨粗鬆症症例における無作為化比較試験によるエルデカルシトールの筋力改善、転倒予防の有用性評価

森優, 斎藤毅, 馬場一慈, 井樋栄二

日本骨粗鬆症学会雑誌　6　(Suppl.1)　349-349　2020/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
乾癬性関節炎に対する抗IL-17A製剤および抗TNF-α製剤の治療効果の比較検討

泉山拓也, 森優, 井樋栄二

日本リウマチ学会総会・学術集会プログラム・抄録集　64回　581-581　2020/08
Publisher: (一社)日本リウマチ学会
乾癬性関節炎に対する抗IL-17A製剤の効果および抗TNF-α製剤との比較検討

泉山拓也, 森優, 大泉樹, 濱田壮志, 井樋栄二

日本整形外科学会雑誌　94　(2)　S152-S152　2020/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
関節リウマチの手指・手関節滑膜炎のダイナミック造影MRIにおける数理モデルの有用性ならびに疾患活動性との相関の検証

森優, 森菜緒子, 常陸真, 泉山拓也, 井樋栄二

日本整形外科学会雑誌　94　(3)　S604-S604　2020/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
関節リウマチにおける薬物治療後の手指・手関節ダイナミックMRIの臨床的意義の検討

森優, 森菜緒子, 常陸真, 泉山拓也, 井樋栄二

日本整形外科学会雑誌　94　(3)　S832-S832　2020/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
乾癬性関節炎に対する抗IL-17A製剤の効果および抗TNF-α製剤との比較検討

泉山拓也, 森優, 井樋栄二

日本リウマチ学会北海道・東北支部学術集会抄録集　29回　101-101　2019/11
Publisher: (一社)日本リウマチ学会-北海道・東北支部
閉経後骨粗鬆症モデルラットにおけるリン酸八カルシウムの溶解性が骨新生に与える影響

馬場一慈, 塩飽由香利, 濱井瞭, 森優, 穴田貴久, 大泉樹, 宮武尚央, 土屋香織, 井樋栄二, 鈴木治

日本バイオマテリアル学会大会予稿集　41回　274-274　2019/11
Publisher: 日本バイオマテリアル学会
硫酸陽極酸化を行った低弾性Ti-Nb-Sn合金の骨伝導能

國井知典, 森優, 田中秀達, 正橋直哉, 花田修治, 井樋栄二

日本整形外科学会雑誌　93　(8)　S1940-S1940　2019/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
骨粗鬆症モデルラットにおけるリン酸八カルシウムの骨新生の評価

馬場一慈, 塩飽由香利, 穴田貴久, 濱井瞭, 森優, 井樋栄二, 鈴木治

日本整形外科学会雑誌　93　(8)　S1973-S1973　2019/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
SLE症例における骨粗鬆症のリスクファクターの検討

森優, 馬場一慈, 泉山拓也, 井樋栄二

日本骨粗鬆症学会雑誌　5　(Suppl.1)　294-294　2019/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
矢状面での脊椎alignmentが転倒にあたえる影響

馬場一慈, 森優, 松田倫治, 井樋栄二

日本骨粗鬆症学会雑誌　5　(Suppl.1)　468-468　2019/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
乾癬性関節炎に対するIL-17A阻害剤の治療効果の検討

泉山拓也, 森優, 井樋栄二

日本リウマチ学会総会・学術集会プログラム・抄録集　63回　747-747　2019/03
Publisher: (一社)日本リウマチ学会
Performance of an octacalcium phosphate biomaterial in a long bone defect in ovariectomized rat

Kazuyoshi Baba, Yukari Shiwaku, Takahisa Anada, Yu Mori, Kaori Tsuchiya, Eiji Itoi, Osamu Suzuki

Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium　40　932　2019/01/01

ISSN： 1526-7547
硫酸陽極酸化を行った低弾性Ti-Nb-Sn合金の表面解析

國井知典, 森優, 田中秀達, 小暮敦史, 正橋直哉, 花田修治, 井樋栄二

日本整形外科学会雑誌　92　(8)　S1791-S1791　2018/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
関節強直に至る関節炎を自然発症するMcH-lpr/lpr-RA1マウスに対するIL-6抑制効果の検討

泉山拓也, 森優, 武田航, 堀江佐知子, 森士朗, 小玉哲也, 井樋栄二

日本整形外科学会雑誌　92　(8)　S1987-S1987　2018/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
臼蓋棚形成術の長期成績

田中秀達, 山田則一, 千葉大介, 森優, 桑原功行, 馬場一慈, 藤井玄二, 大山正瑞, 北純, 井樋栄二

日仏整形外科学会プログラム・抄録集　18th　2018
骨粗鬆症モデルラットによるリン酸オクタカルシウムの骨組織応答性に関する研究

馬場一慈, 塩飽由香利, 穴田貴久, 濱井瞭, 森優, 井樋栄二, 鈴木治

日本バイオマテリアル学会大会予稿集(Web)　40th　218 (WEB ONLY)-218　2018
Publisher: 日本バイオマテリアル学会
陽極酸化を施したTiNbSn合金の骨伝導性

正橋直哉, 森優, 田中秀達, 小暮敦史, 井樋栄二, 井上博之, 花田修治

日本金属学会講演概要(CD-ROM)　160th　2017

ISSN： 2433-3093
寛骨臼上脆弱性骨折有限要素解析による力学的発症メカニズムの解明

田中秀達, 山子剛, 栗島宏明, 千葉大介, 森優, 桑原功行, 小暮敦史, 馬場一慈, 帖佐悦男, 井樋栄二

日本骨粗鬆症学会雑誌　2　(Suppl.1)　252-252　2016/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
低弾性チタン合金Ti-Nb-Sn製の髄内釘による内固定は骨癒合を促進する

小暮敦史, 森優, 田中秀達, 花田修治, 正橋直哉, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1722-S1722　2016/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
陽極酸化と温水処理を施行した低弾性β型Ti-Nb-Sn合金の生体内における骨親和性の検討 Focused ion beamを用いた金属と骨界面の微細構造評価

田中秀達, 森優, 小暮敦史, 正橋直哉, 花田修治, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1811-S1811　2016/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Bioactivity of Surface Modified TiNbSn Alloy for Biomedical Implant

64　(3)　216-221　2016/07
Publisher: 日本チタン協会
ISSN： 1341-1713
表面改質を施したインプラント用TiNbSn合金の生体活性

正橋直哉, 森優, 田中秀達, 小暮敦史, 野呂篤司, 上村雅之, 山田則一, 井樋栄二, 花田修治

チタン　64　(3)　50-55　2016

ISSN： 1341-1713
陽極酸化処理と温水処理を施行した低弾性β型Ti-Nb-Sn合金の生体内における骨固着能評価

田中秀達, 森優, 野呂篤司, 小暮敦史, 山田則一, 正橋直哉, 花田修治, 井樋栄二

日本整形外科学会雑誌　89　(8)　S1735-S1735　2015/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
陽極酸化処理と温水処理を施行した低弾性β型Ti-Nb-Sn合金の生体内における骨固着能評価

田中秀達, 森優, 野呂篤司, 小暮敦史, 山田則一, 正橋直哉, 花田修治, 井樋栄二

日本骨代謝学会学術集会プログラム抄録集　33回　201-201　2015/07
Publisher: (一社)日本骨代謝学会
ISSN： 1349-0761
下顎枝が吸収し側頭骨、脳硬膜まで病変が波及したSAPHO症候群の1例

佐藤修一, 高橋哲, 熊本裕行, 森優

日本顎関節学会雑誌　26　(Suppl.)　138-138　2014/07
Publisher: (一社)日本顎関節学会
ISSN： 0915-3004

eISSN： 1884-4308
頸椎椎間関節の強直をきたした乾癬性関節炎(psoriatic arthritis)の1例

柴山一洋, 大津進, 佐藤俊一郎, 今川啓, 森優, 塩澤広重, 今泉秀樹

東北整形災害外科学会雑誌　57　(1)　65-69　2014/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
その他の膠原病・アミロイドーシス当科における乾癬性関節炎症例の治療成績の検討

森優, 井樋栄二

日本リウマチ学会総会・学術集会プログラム・抄録集　58回　419-419　2014/03
Publisher: (一社)日本リウマチ学会
その他の膠原病手指に発症した骨サルコイドーシス症例の検討

森優, 奥野洋史, 小倉健, 井樋栄二

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集　57回・22回　345-345　2013/03
Publisher: (一社)日本リウマチ学会
骨移植を併用せずにプレート固定をした踵骨関節内骨折の治療成績

佐藤俊一郎, 今泉秀樹, 大津進, 森優, 今川啓

骨折　34　(1)　153-155　2012/02
Publisher: (一社)日本骨折治療学会
ISSN： 0287-2285

eISSN： 2434-6055
頸椎椎間関節の強直をきたした乾癬性関節炎(psoritic arthritis=PsA)の1例

柴山一洋, 大津進, 森優, 今川啓, 佐藤俊一郎, 今泉秀樹, 塩沢広重

東北整形災害外科学会雑誌　54　(1)　96-96　2010/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
セメントレス人工骨頭挿入術中に肺血栓塞栓症を発症した一例

大津進, 森優, 今川啓, 佐藤俊一郎, 今泉秀樹

大崎市民病院誌　12　(1)　43-46　2008/12
Publisher: 大崎市民病院
ISSN： 1881-6142
術後12年で遠隔転移をおこしたsclerosing epithelioid fibrosarcomaの1例

菅野敦子, 保坂正美, 羽鳥正仁, 岸本光司, 森優, 井樋栄二, 石橋賢太郎, 渡辺みか

東北整形災害外科学会雑誌　52　(1)　152-153　2008/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
関節リウマチ患者に対するMagna-Rom 21人工膝関節置換術の臨床成績

小倉健, 大津進, 伊澤亮平, 森優, 奥野洋史, 井樋栄二

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集　52回・17回　338-338　2008/04
Publisher: (一社)日本リウマチ学会
【骨と免疫】免疫グロブリン様受容体と骨代謝 Invited

高井俊行, 乾匡範, 森優

腎と骨代謝　21　(1)　43-50　2008/01
Publisher: (株)日本メディカルセンター
ISSN： 0914-5265

eISSN： 2433-2496
【炎症と破骨細胞】破骨細胞を制御するレセプター群 Invited

森優, 乾匡範, 高井俊行

炎症と免疫　14　(5)　615-619　2006/08
Publisher: (株)先端医学社
ISSN： 0918-8371
【加齢の生化学】破骨細胞の分化制御機構と骨疾患 Invited

乾匡範, 森優, 高井俊行

生化学　78　(3)　250-256　2006/03
Publisher: (公社)日本生化学会
ISSN： 0037-1017
Regulatory mechanisms of osteoclast development and bone disorders

Masanori Inui, Y. Mori, Toshiyuki Takai

Seikagaku. The Journal of Japanese Biochemical Society　78　(3)　250-256　2006/03

ISSN： 0037-1017
【関節リウマチの最新動向骨免疫学的視点からの病因論・治療学】破骨細胞分化機構 IgLRによる破骨細胞の分化制御 Invited

高井俊行, 乾匡範, 井上和也, 森優

日本臨床　63　(9)　1562-1568　2005/09
Publisher: (株)日本臨床社
ISSN： 0047-1852
Regulation of osteoclast development by immunoglobulin-like receptors Invited

Toshiyuki Takai, Masanori Inui, Kazuya Inoue, Y. Mori

Nippon rinsho. Japanese journal of clinical medicine　63　(9)　1562-1568　2005/09

ISSN： 0047-1852
前骨間神経麻痺の電気診断と治療成績

信田進吾, 佐藤克巳, 小松哲郎, 小倉健, 森優

日本肘関節学会雑誌　11　(1)　163-164　2004/12
Publisher: 日本肘関節学会
ISSN： 1349-7324

eISSN： 2434-2262
肘関節に発生した滑膜性骨軟骨腫症の1例

森優, 信田進吾, 小松哲郎, 千本英一, 佐藤克巳

東北整形災害外科学会雑誌　48　(1)　83-83　2004/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Subcutaneous rupture of the extensor pollicis longus tendon after fracture of the distal radius : report of two cases

MORI Yu, NOBUTA Shingo, SATO Katsumi, KOMATSU Tetsuro, OGURA Ken

48　(1)　58-61　2004/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
外傷性肘関節拘縮に対する関節解離術の治療成績

信田進吾, 佐藤克巳, 小松哲郎, 笠間史夫, 小倉健, 森優

日本整形外科学会雑誌　78　(4)　S479-S479　2004/04
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
前骨間神経麻痺の電気診断と治療経験

信田進吾, 佐藤克巳, 小松哲郎, 森優, 兼子忠延

総合リハビリテーション　32　(3)　267-270　2004/03
Publisher: (株)医学書院
ISSN： 0386-9822

eISSN： 1882-1340
手根管症候群に対する手関節装具療法の治療成績

信田進吾, 佐藤克巳, 小松哲郎, 小倉健, 森優

日本手の外科学会雑誌　21　(1)　S38-S38　2004/03
Publisher: (一社)日本手外科学会
ISSN： 0910-5700
症例肘関節に発生した滑膜性骨軟骨腫症の1例

森優, 信田進吾, 佐藤克巳

整形・災害外科　46　(12)　1505-1508　2003/11
Publisher: 金原出版
ISSN： 0387-4095
Clinical Results of Stabilized Anterior Subcutaneous Transposition of the Ulnar Nerve for Cubital Tunnel Syndrome

NOBUTA Shingo, SATO Katsumi, KOMATSU Tetsuro, CHIMOTO Eiichi, MORI Yu

20　(2)　84-87　2003/08/25
Publisher: (一社)日本手外科学会
ISSN： 0910-5700
間欠跛行に対する20mシャトル・ウォーキングテストとトレッドミル検査の吟味

小松哲郎, 佐藤克巳, 笠間史夫, 小松田辰郎, 曽根茂樹, 日下部隆, 千本英一, 森優, 益本真太郎

東北整形災害外科紀要　47　(1)　108-108　2003/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
A case of pyogenic spondylitis with large abscess caused by Streptococcus constellatus

MORI Yu, KOIZUMI Yutaka

47　(1)　9-13　2003/06/01
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
The experiences of ankle arthrodesis with Transfibular approach for rheumatoid arthritis patients

MORI Yu, SAITO Koichi, IWAI Kazuo

47　(1)　66-69　2003/06/01
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
超音波画像のナビゲーションによる坐骨神経ブロックInterventional ultrasound navigation in the musculoskeletal system

小松哲郎, 信田進吾, 千本英一, 森優, 山下安夫, 桜庭勝

超音波医学　30　(3)　J360-J361　2003/05
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
重度手根管症候群の治療成績と電気診断学的推移

信田進吾, 佐藤克巳, 小松哲郎, 笠間史夫, 千本英一, 森優

日本整形外科学会雑誌　77　(3)　S312-S312　2003/03/25
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
鎖骨近位端に発生した軟骨腫の1例

立花利江, 岩井和夫, 斉藤宏一, 古泉豊, 吉田政史, 石倉透, 森優

東北整形災害外科紀要　46　(2)　228-229　2002/12
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
広範な腹膜周囲膿瘍を併発した化膿性脊椎炎の1例

森優, 古泉豊, 岩井和夫, 齊藤宏一, 立花利江, 吉田政史, 石倉透

東北整形災害外科紀要　46　(2)　242-242　2002/12
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
健側として測定された関節可動域の検討

岩井和夫, 斉藤宏一, 古泉豊, 立花利江, 吉田政史, 萩原宏樹, 森優

日本職業・災害医学会会誌　50　(臨増)　139-139　2002/09
Publisher: (一社)日本職業・災害医学会
ISSN： 1345-2592
頸椎硬膜外嚢腫の1例

石倉透, 古泉豊, 岩井和夫, 斉藤宏一, 早坂俊雄, 立花利江, 吉田政史, 森優

東北整形災害外科紀要　46　(1)　109-109　2002/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
脱臼性股関節症の経過観察例

齊藤宏一, 岩井和夫, 古泉豊, 早坂俊雄, 吉田政史, 石倉透, 森優, 那須孝邦

東北整形災害外科紀要　46　(1)　119-119　2002/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
慢性関節リウマチ足関節病変に対する手術症例の検討

森優, 齊藤宏一, 岩井和夫, 古泉豊, 立花利江, 吉田政史, 石倉透, 大平信廣, 井上尚美

東北整形災害外科紀要　46　(1)　125-125　2002/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
腰椎分離辷り症によるfar-out syndromeの1例

古泉豊, 石倉透, 岩井和夫, 斎藤宏一, 早坂俊雄, 吉田政史, 森優

東北整形災害外科紀要　46　(1)　129-129　2002/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
人工股関節置換術における手術操作と経食道エコーによる右心房内輝度変化

齊藤宏一, 岩井和夫, 古泉豊, 立花利江, 吉田政史, 石倉透, 森優, 洪浩彰

日本整形外科学会雑誌　76　(3)　S88-S88　2002/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
高位脛骨骨切り術を行った大腿骨内側顆骨壊死の5例

吉田政史, 岩井和夫, 斉藤宏一, 古泉豊, 早坂俊雄, 古子剛, 森優

東北整形災害外科紀要　45　(2)　270-270　2001/12
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
第一趾ガングリオン症例の検討

森優, 岩井和夫, 斉藤宏一, 古泉豊, 早坂俊雄, 吉田政史, 古子剛

東北整形災害外科紀要　45　(1)　135-135　2001/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
腰椎部慢性硬膜外血腫の1例

早坂俊雄, 古泉豊, 岩井和夫, 斉藤宏一, 吉田政史, 古子剛, 森優

東北整形災害外科紀要　45　(1)　121-122　2001/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751

Show all ︎Show first 5

Books and Other Publications 2

Posture analysis in patients with spinal osteoporosis. Non-Pharmacological Management of Osteoporosis: Exercise, Nutrition, Fall and Fracture Prevention.

Itoi E, Mori Y, Sinaki M, Pfeifer M

2017
骨粗鬆症の予防と治療ガイドライン2015年版

井樋栄二, 森優

2015

Presentations 99

Year in Review AxSpAの診断と強直進行予測の取り組み Invited

森優

日本脊椎関節炎学会第35回学術集会
実臨床に則したリウマチ疾患の真実整形外科医からみた脊椎関節炎の診断と治療 Invited

森優

第98回日本整形外科学会学術総会
Type C1およびC2の大腿骨頭壊死症患者の寛骨臼形態が骨頭圧壊と股関節機能に与える影響に関する後ろ向き調査

川又裕輝, 田中秀達, 馬場一慈, 栗山恭明, 金淵龍一, 福地英輝, 森優, 相澤俊峰

第98回日本整形外科学会学術総会
腰椎変性後彎症のゲノムワイド関連解析東北6大学による多施設共同研究

橋本功, 長崎正朗, 植野和子, 大橋正幸, 鈴木智人, 菅野晴夫, 渡邉和之, 山部大輔, 森優, 徳永勝士, 相澤俊峰

第98回日本整形外科学会学術総会
DPCデータベースを用いた超高齢大腿骨近位部骨折患者における術後合併症発生率と院内死亡率の検討

千葉美詩央, 森優, たら澤邦男, 田中秀達, 金淵龍一, 畠山拡, 森菜緒子, 伏見清秀, 藤森研司, 相澤俊峰

第98回日本整形外科学会学術総会
新型コロナウイルス感染症パンデミックの大腿骨近位部骨折患者の合併症に与える影響日本におけるDPCデータベースからの研究

田中秀達, たら澤邦男, 森優, 伏見清秀, 藤森研司, 相澤俊峰

第98回日本整形外科学会学術総会
骨粗鬆症患者における腰痛と脊柱・骨盤・下肢アライメントの相互関係の検討

藤田涼, 高橋康平, 大野木孝嘉, 八幡健一郎, 小野田祥人, 森優, 橋本功, 相澤俊峰

第98回日本整形外科学会学術総会
高齢者の股関節骨折転帰と週末入院の影響日本のDPCデータベースからの研究

森優, たら澤邦男, 田中秀達, 森菜緒子, 伏見清秀, 藤森研司, 相澤俊峰

第98回日本整形外科学会学術総会
日本人体軸性脊椎関節炎患者の脊椎強直性病変進行に関連するリスク因子の検討

畠山拡, 森優, 泉山拓也, 金淵龍一, 千葉美詩央, 相澤俊峰

第98回日本整形外科学会学術総会
Stage 1大腿骨頭壊死患者の予後に関する検討

田中秀達, 馬場一慈, 金淵龍一, 栗山恭明, 川又裕輝, 福地英輝, 森優, 相澤俊峰

第98回日本整形外科学会学術総会
全国DPCデータベース分析による関節リウマチ併存高齢患者の大腿骨近位部骨折術後合併症リスクの検討

金淵龍一, 森優, 馬場一慈, 田中秀達, 栗山恭明, 畠山拡, 千葉美詩央, 相澤俊峰

第98回日本整形外科学会学術総会
体軸性脊椎関節炎と乾癬性関節炎の治療薬をどのように使い分けるか? 体軸性脊椎関節炎に対するTNF阻害薬の位置づけ Invited

森優

第69回日本リウマチ学会総会・学術集会
DPCデータベースを用いた高齢関節リウマチ患者の大腿骨近位部骨折における術後合併症リスク評価

金淵龍一, 森優, 畠山拡, 千葉美詩央, 相澤俊峰

第69回日本リウマチ学会総会・学術集会
日本人体軸性脊椎関節炎患者の脊椎強直性病変進行に関連するリスク因子の検討

畠山拡, 森優, 泉山拓也, 金淵龍一, 千葉美詩央, 相澤俊峰

第69回日本リウマチ学会総会・学術集会
難治性の頭骨・顎骨骨炎を来したSAPHO症候群の検討

千葉美詩央, 森優, 金淵龍一, 畠山拡, 相澤俊峰

第69回日本リウマチ学会総会・学術集会
Analysis of osteogenic capacity of an octacalcium phosphate bone substitute used in orthopedic bone defect filling,

Osamu Suzuki, Yu Mori, Ryo Hamai, Susumu Sakai, Kaori Tsuchiya, Toshimi Aizawa

Society for Biomaterial 2025 Annual meeting
リン酸オクタカルシウム／ゼラチン（OCP／ゲル）複合体の腰椎椎体固定における実験的検討について

森優, 濱井瞭, 金淵龍一, 相澤俊峰, 鈴木治

日本バイオマテリアル学会シンポジウム2024
ケモカインを担持したリン酸八カルシウム/PLGA複合体への骨組織応答の評価

栗山恭明, 濱井瞭, 森優, 馬塲一慈, 土屋香織, 金淵龍一, 原田健登, 相澤俊峰, 鈴木治

日本バイオマテリアル学会シンポジウム2024
リン酸八カルシウムと間質由来因子1のラット長管骨欠損修復における相乗効果

金淵龍一, 濱井瞭, 塩鮑由香利, 森優, 土屋香織, 蔡優広, 濱田壮志, 栗山恭明, 相澤俊峰, 鈴木治

日本バイオマテリアル学会シンポジウム2024
OCPの整形外科領域への臨床応用に向けた検討について Invited

森優

日本バイオマテリアル学会シンポジウム2024
D2T RAを予防する関節リウマチの治療戦略 Invited

森優

公益社団法人日本整形外科学会第42回リウマチ医研修会(応用)
全国DPCデータベース分析による関節リウマチ合併高齢大腿骨近位部骨折患者の術後続発症リスクの検討

金淵龍一, 森優, 畠山拡, 相澤俊峰

第34回日本リウマチ学会北海道・東北支部学術集会山形 2024年10月19-20日
RAにおけるIL-6阻害は術後創部癒合遅延および創部感染と関連するか？ Invited

森優

第34回日本リウマチ学会北海道・東北支部学術集会山形 2024年10月19-20日
低弾性率チタン(TiNbSn)合金製ロッキングプレートはラット大腿骨骨切り部の骨癒合を促進する.

古山和樹, 森優, 上村雅之, 田中秀達, 伊東健太郎, 古口昌志, 原田健登, 内海峻輔, 畠山拡, 正橋直哉, 相澤俊峰

第39回日本整形外科学会基礎学術集会
骨折の有無で比較検討した、骨粗鬆症治療中の関節リウマチ患者の特徴

泉山拓也, 森優, 栗山恭明, 金淵龍一, 相澤俊峰

第26回日本骨粗鬆症学会
ケモカイン担持によるリン酸八カルシウム/PLGA複合体の骨再生能強化の検討

栗山恭明, 濱井瞭, 森優, 馬塲一慈, 土屋香織, 金淵龍一, 原田健登, 相澤俊峰, 鈴木治

セラミックス協会第37回秋季シンポジウム
第7回七川アッヴィ賞受賞講演：SAPHO症候群の放射線学的特徴と臨床的多様性の検討 Invited

森優

日本脊椎関節炎学会第34回学術集会
関節リウマチに対する薬物治療：biologic DMARDs Invited

森優

公益社団法人日本整形外科学会第41回リウマチ医研修会(資格取得・基礎)
Anterolateral supine approach THAにおける内閉鎖筋共同腱の解離が臨床転帰および股関節周囲筋筋力に与える影響は限定的である

田中秀達, 山田則一, 栗島宏明, 馬塲一慈, 森優, 相澤俊峰

第97回日本整形外科学会学術総会
大規模言語モデルを用いた画像診断データ解析によるSAPHO症候群の診断性能の検討

森優, 泉山拓也, 金淵龍一, 森菜緒子, 相澤俊峰

第97回日本整形外科学会学術総会
体軸性脊椎関節炎患者における脊椎病変進行関連因子の解明

泉山拓也, 森優, 金淵龍一, 相澤俊峰

第68回日本リウマチ学会総会・学術集会
仰臥位前外側アプローチによる人工股関節全置換術後の脱臼危険因子の検討

金淵龍一, 森優, 泉山拓也, 相澤俊峰

第68回日本リウマチ学会総会・学術集会
大規模言語モデルを用いた画像診断データ解析によるSAPHO症候群の診断性能の検討.

森優, 泉山拓也, 金淵龍一, 相澤俊峰

第68回日本リウマチ学会総会・学術集会
リン酸八カルシウム/PLGA複合体のラット大腿骨骨欠損修復効果

栗山恭明, 濱井瞭, 森優, 馬塲一慈, 土屋香織, 金淵龍一, 原田健登, 相澤俊峰, 鈴木治

第23回日本再生医療学会総会
陽極酸化Ti02の光触媒活性に及ぼす基板依存性

正橋直哉, 久保田真彩, 目代貴之, 森優, 栗島宏明, 井上博之, 相澤俊峰, 花田修治

第174回日本金属学会講演大会
リン酸八カルシウム/ゼラチン複合体の開発と難治性骨欠損における骨修復性能の検討 Invited

森優, 濱井瞭, 相澤俊峰, 鈴木治

第42回整形外科バイオマテリアル研究会
陽極酸化処理によるTiNbSn合金の抗菌性能付与と骨親和性改善効果 Invited

森優, 正橋直哉, 相澤俊峰

第42回整形外科バイオマテリアル研究会
ラット長管骨欠損におけるリン酸八カルシウムと間質由来因子-1の骨再生に関する相乗効果

金淵龍一, 濱井瞭, 塩飽由香利, 森優, 土屋香織, 蔡優広, 濵田壮志, 栗山恭明, 原田健登, 相澤俊峰, 鈴木治

第25回生体関連セラミックス討論会
ケモカイン担持リン酸八カルシウムのラット長管骨欠損修復能の評価

金淵龍一, 濱井瞭, 塩飽由香利, 森優, 土屋香織, 蔡優広, 濵田壮志, 栗山恭明, 原田健登, 相澤俊峰, 鈴木治

第45回日本バイオマテリアル学会
ラット大腿骨皮質骨欠損におけるOCP/Gel, Gel, β-TCPの骨修復能の検討

森優, 金淵龍一, 濱井瞭, 土屋香織, 馬場一慈, 濱田壮志, 相澤俊峰, 鈴木治

第45回日本バイオマテリアル学会
Baricitinibの特徴とこれからの関節リウマチ治療で求められる役割 Invited

森優

第48回日本足の外科学会学術集会
リン酸オクタカルシウム/ゼラチン多孔質複合体のラット大腿骨両側皮質骨欠損モデルに対する骨修復能の放射線学的・組織学的評価

金淵龍一, 森優, 濱井瞭, 土屋香織, 宮武尚史, 馬場一慈, 濱田壮志, 栗山恭明, 原田健登, 相澤俊峰, 鈴木治

第38回日本整形外科学会基礎学術集会
関節リウマチ症例に対する下肢関節手術の変化 Invited

森優

第33回日本リウマチ学会北海道・東北支部学術集会
整形外科医からみた脊椎関節炎の診断と治療 Invited

森優

第33回日本脊椎関節炎学会
整形外科医による関節リウマチの治療戦略 Invited

森優

第51回日本関節病学会
人工関節周囲感染診断におけるalpha-defensin検査の有用性について Invited

森優, 千葉大介, 上村雅之, 金淵龍一, 馬場一慈, 相澤俊峰

第46回日本骨・関節感染症学会
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連.

森優, 千葉大介, 橋本功, 馬場一慈, 田中秀達, 植野和子, 長崎正朗, 相澤俊峰

第96回日本整形外科学会学術総会
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 綿貫宗則, 吉田新一郎, 森菜緒子, 相澤俊峰

第96回日本整形外科学会学術総会
新規に開発した同一stem内で剛性が変化するstem(TiNbSn stem)のstress shielding予防効果

馬場一慈, 千葉大介, 森優, 田中秀達, 小暮敦史, 桑原功行, 山田則一, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

第96回日本整形外科学会学術総会
Chiari骨盤骨切り術の術後平均32年の長期成績と予後予測因子の検討

栗島宏明, 千葉大介, 馬場一慈, 濱田壮志, 鈴木貴之, 金淵龍一, 藤井玄二, 大山正瑞, 落合達宏, 森優, 相澤俊峰

第96回日本整形外科学会学術総会
生物学的製剤使用下における,体軸性脊椎関節炎の脊椎強直進行因子の検討

泉山拓也, 森優, 栗山恭明, 金淵龍一, 相澤俊峰

第96回日本整形外科学会学術総会
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 金淵龍一

第67回日本リウマチ学会総会・学術集会
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 泉山拓也, 金淵龍一

第67回日本リウマチ学会総会・学術集会
体軸性脊椎関節炎患者における脊椎病変進行の関連因子の解明

泉山拓也, 森優, 金淵龍一

第67回日本リウマチ学会総会・学術集会
Bone repair effect of octacalcium phosphate/gelatin porous composite on refractory bone defects in rat femur

Osamu Suzuki, Yu Mori, Ryo Hamai, Kaori Tsuchiya, Itsuki Oizumi, Soshi Hamada, Ryuichi Kanabuchi, Toshimi Aizawa

Society for Biomaterials 2023 Annual Meeting
陽極酸化TiNbSn合金の光誘起特性

正橋直哉, 久保田真彩, 森優, 井上博之, 目代貴之, 花田修司

第120回日本金属学会
Effect of low Young's modulus Ti-Nb-Sn alloy locking plate on bone healing

Masashi Koguchi, Yu Mori, Ketaro Ito, Tomoki Koyama, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Toshimi Aizawa

2023 ORS annual meeting
Effect of OCP/PLGA composites on MSC differentiation and the materials hydrolyses

Ryo Hamai, Itsuki Oizumi, Yukari Shiwaku, Yu Mori, Takahisa Anada, Kazuyoshi Baba, Naohisa Miyatake, Shin-nosuke Nishimura, Toshimi Aizawa, Eiji Itoi, Osamu Suzuki

Society for biomaterials 2022 annual meeting
リン酸オクタカルシウム/ゼラチン多孔質複合体を用いたラット大腿骨難治性骨欠損に対する骨修復効果について

金淵龍一, 森優, 濱井瞭, 土屋香織, 宮武尚久, 馬場一慈, 大泉樹, 濱田壯志, 相澤俊峰, 鈴木治

第41回整形外科バイオマテリアル研究会
関節リウマチ治療の最適化の取り組み Invited

森優

第49回日本股関節学会
低弾性率チタン合金製ロッキングプレートによるウサギ脛骨骨切り部の骨癒合促進効果

古口昌志, 森優, 伊東健太郎, 古山和樹, 正橋直哉, 花田修二, 相澤俊峰

第37回日本整形外科学会基礎学術集会
陽極酸化TiNbSn合金の光誘起性能

正橋直哉, 久保田真彩, 目代貴之, 森優, 栗島宏明, 井上博之, 相澤俊峰, 花田修治

第171回日本金属学会講演大会
ステロイド性骨粗鬆症におけるロモソズマブの治療成績-前治療薬による比較と導入前骨代謝マーカーから見た治療効果の予測-

高橋忠久, 森優, 藤盛理子, 相澤俊峰

第24回日本骨粗鬆症学会
一次繊毛を介した骨形成における膜裏打ちタンパク質4.1Gの役割

斎藤将樹, 森優, 伊東健太郎, 齊藤百合花, 寺田信生

第74回日本細胞生物学会
関節リウマチ患者の骨粗鬆症対策 Invited

森優

第119回東北整形災害外科学会
股関節内旋制動における外旋筋や後方関節包の機能が、股関節屈曲角度で異なるか Cadaverを用いた研究

馬場一慈, 千葉大介, 森優, 桑原功行, 小暮敦史, 菅谷岳広, 鈴木貴之, 栗島宏明, 浜田壮志, 井樋栄二, 相澤俊峰

第95回日本整形外科学会学術集会
整形外科医からみた乾癬性関節炎の病態と治療 Invited

森優

第95回日本整形外科学会学術集会
人工股関節置換術の術中関節可動域と術後の靴下の着脱・爪切り動作の満足度についての検討(会議録)

田中秀達, 山田則一, 栗島宏明, 坂本敬, 森優, 大沼正宏, 大山正瑞, 相澤俊峰, 北純

第95回日本整形外科学会学術集会
Anterolateral supine approach(ALSA) THAにおける内閉鎖筋共同腱の温存・解離の臨床的意義について

田中秀達, 山田則一, 栗島宏明, 坂本敬, 森優, 大沼正宏, 大山正瑞, 相澤俊峰, 北純

第95回日本整形外科学会学術集会
ダイナミック造影MRIのヒストグラム解析の数理モデルによる関節リウマチの薬物治療効果判定の検討

森優, 泉山拓也, 相澤俊峰

第95回日本整形外科学会学術集会
閉経後関節リウマチ患者におけるビスフォスフォネート製剤から切り替え後のデノスマブによる関節破壊防止効果

森優, 泉山拓也, 相澤俊峰

第95回日本整形外科学会学術集会
リウマチ整形外科医の現状と未来～今後どのような方向へ向かうべきか?～関節リウマチ診療の課題と展望整形外科医の立場から Invited

森優

第67回日本リウマチ学会総会学術集会
リウマチ性疾患における感染症人工関節周囲感染に対するalpha-defensin検出キットの有用性

金淵龍一, 森優, 泉山拓也

第66回日本リウマチ学会総会学術集会
骨粗鬆症と骨代謝閉経後関節リウマチ患者におけるビスホスホネート製剤から切り替え後のデノスマブによる関節破壊防止効果

森優, 泉山拓也, 金淵龍一

第66回日本リウマチ学会総会学術集会
関節リウマチ治療におけるIL-6制御の意義 Invited

森優

第31回日本リウマチ学会北海道・東北支部学術集会
一次繊毛を介した骨芽細胞分化における膜裏打ちタンパク質4.1Gの役割

斎藤将樹, 泉朋宏, 森優, 齊藤百合花, 寺田信生

第94回日本生化学大会
酒石酸ナトリウム電解浴で陽極酸化したTNS合金の抗菌能

栗島宏明, 森優, 正橋直哉, 石井恵子, 井上博之, 畠山美樹, 花田修治, 川上和義, 井樋栄二, 相澤俊峰

第36回日本整形外科学会基礎学術集会
低弾性率チタン合金製プレートによるウサギ脛骨骨切り部の骨癒合促進効果

伊東健太郎, 森優, 國井知典, 栗島宏明, 古口昌志, 藤盛理子, 正橋直哉, 花田修治, 井樋栄二, 相澤俊峰

第36回日本整形外科学会基礎学術集会
ビスフォスフォネートから治療変更したデノスマブの抗CCP抗体陽性関節リウマチ症例における骨関節破壊の抑制効果の検討

森優, 泉山拓也, 井樋栄二, 相澤俊峰

第23回日本骨粗鬆症学会
関節リウマチにおける薬物治療後の手指・手関節ダイナミックMRIの臨床的意義の検討

森優, 泉山拓也, 井樋栄二

第66回日本リウマチ学会総会・学術集会
Effects of Elastic Plate of Low Young's Modulus Ti-Nb-Sn-alloy on Bone Healing

Kentaro Ito, Yu Mori, Tomonori Kunii, Hiroaki Kurishim, Masashi Koguchi, Satoko Fujimori, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi

ORS 2021 Annual meeting
The antibacterial activity of anodized biocompatible TiNbSn alloy prepared in sodium tartrate

Hiroaki Kurishima, Yu Mori, Naoya Masahashi, Keiko Ishii, Hiroyuki Inoue, Shuji Hanada, Kazuyoshi Kawakami, Eiji Itoi

ORS 2021 Annual meeting
Effective parameters of Dynamic Contrast-Enhanced MRI of finger and wrist joints to evaluate drug treatment response in rheumatoid arthritis patients

Yu Mori, Naoko Mori, Takuya Izumiyama, Eiji Itoi

ORS 2021 Annual meeting
閉経後骨粗鬆症症例における無作為化比較試験によるエルデカルシトールの筋力改善、転倒予防効果の検討

森優, 斎藤毅, 馬場一慈, 井樋栄二

第22回日本骨粗鬆症学会
日本人ステロイド骨粗鬆症症例における椎体骨折の危険因子の検討

森優, 泉山拓也, 馬場一慈, 井樋栄二

第22回日本骨粗鬆症学会
ラット長管骨骨欠損モデルにおける新規骨補填材のリン酸八カルシウムと乳酸グリコール酸共重合体複合体による骨修復効果の検討

大泉樹, 森優, 塩鮑由香利, 濱井瞭, 馬場一慈, 穴田貴久, 井樋栄二, 鈴木治

第35回日本整形外科学会基礎学術集会
関節リウマチの手指・手関節滑膜炎のダイナミック造影MRIにおける数理モデルの有用性並びに疾患活動性との相関の検証

森優, 森菜緒子, 常陸真, 泉山拓也, 井樋栄二

第93回日本整形外科学会学術集会
関節リウマチにおける薬物治療後の手指・手関節ダイナミック造影MRIの臨床的意義の検討関節リウマチにおける薬物治療後の手指・手関節ダイナミック造影MRIの臨床的意義の検討

森優, 森菜緒子, 常陸真, 泉山拓也, 井樋栄二

第93回日本整形外科学会学術集会
乾癬性関節炎に対する抗IL-17A製剤および抗TNF-α製剤の治療効果の比較検討

泉山拓也, 森優, 大泉樹, 濵田壮志, 井樋栄二

第93回日本整形外科学会学術集会
日本人ゲノム解析ツールによる運動器疾患の疾患感受性遺伝子の探索 Invited

森優

第46回日本股関節学会学術集会
Performance of an octacalcium phosphate biomaterial in a long bone defect on ovariectomized rat

Baba K., Shiwaku Y., Anada T., Mori Y., Tsuchiya K., Itoi E., Suzuki O.

42nd Society for Biomaterials Annual Meeting and Exposition
Improved Osseointegration of a TiNbSn Alloy with a Low Young’s Modulus Treated with Anodic Oxidation.

Kunii T., Mori Y., Tanaka H., Kogure A., Masahashi N., Itoi E.

2019 ORS annual meeting
The effect of anti-IL-6 receptor antibody for the treatment of MCH-lpr/lpr-RA1 mice that spontaneously develop ankylosing arthritis.

Izumiyama T., Mori Y., Mori S., Takeda K., Horie S., Kodama T., Itoi E.

20th Asia Pacific League of Associations for Rheumatology Congress
Biomechanical Analysis of Supra-Acetabular Insufficiency Fracture

Hidetatsu Tanaka, Go Yamako, Hiroaki Kurishima, Shutaro Yamashita, Yu Mori, Daisuke Chiba, Etsuo Chosa, Eiji Itoi

ORS 2017 annual meeting
Interface Analysis of the low Young’s Modulus Ti-Nb-Sn Alloy with Anodic Oxidation and Hot Water Treatment implanted to rabbit femur

Hidetatsu Tanaka, Yu Mori, Atsushi Kogure, Shuji Hanada, Naoya Masahashi, Eiji Itoi

ORS 2017 annual meeting
The effects of elastic intramedullary nails of low Young's modulus new β type Ti-Nb-Sn alloy on fracture healing in mice.

H Fujisawa, Y Mori, M Kamimura, S Hanada, E Itoi

ORS 2017 annual meeting
Effects of Elastic Intramedullary Nails of Low Young's Modulus Ti-Nb-Sn-alloy on Bone Healing

Atsushi Kogure, Yu Mori, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi

ORS 2017 annual meeting
The Apatite forming Ability of The New TiNbSn Alloy With low Young’S Modulus Via Anodic Oxidation And Hot Water Treatment

Hidetatsu Tanaka, Yu Mori, Atsushi Noro, Norikazu Yamada, Shuji Hanada, Naoya Masahashi, Eiji Itoi

ORS 2016 annual meeting
続発性骨粗鬆症の病態と治療戦略 Invited

森優

第50回日本骨折治療学会学術集会　2024/06/28

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Industrial Property Rights 2

骨再生材料、骨再生材料の製造方法、骨再生材料製造装置

Property Type: Patent
生体用チタン合金及びその製造方法

Property Type: Patent

Research Projects 14

生体親和性と抗菌性能を両立する低弾性率チタン合金材料の開発

上村雅之, 森優

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04 - 2027/03
低骨代謝状態における低弾性率チタン合金プレートの骨癒合促進効果の検証

田中秀達、森優

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04 - 2027/03
Development of bone graft substitutes with both osteogenic potential and high strength

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2023/04 - 2026/03
Electrophysiological characterisation of breast cancer by minimally invasive MR conductivity mapping.

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2022/04 - 2025/03
骨再生能と高弾性を有する骨補填材開発の試み

鈴木治, 濱井瞭, 塩飽由香利, 森優

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(B)

Category: 基盤研究(B)

Institution: 東北大学

2021/04/01 - 2024/03/31
Role of cytoskeletal protein 4.1G on bone formation and improvement in pathophysiology of osteoporosis

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2021/04 - 2024/03
Study of biocompatible implant TiNbSn alloy

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2020/04 - 2024/03
ジャポニカアレイを用いた股関節形成不全の疾患感受性遺伝子の探索

千葉大介, 橋本功, 森優

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2020/04/01 - 2023/03/31

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発育性股関節形成不全(developmental dysplasia of the hip: DDH)は日本人に好発する家族集積性の高い疾患である。また本邦では変形性股関節症の約80％はDDHを原因としている。変形性股関節症に対する人工股関節置換術は年間約10万件となり、増加傾向である。変形性股関節症の予防のためにDDHの病態解明は必須であるが、DDHの原因遺伝子は未解明である。当施設では日本人ゲノム解析ツールであるジャポニカアレイを開発している。日本人に最適化されたジャポニカアレイを用いたDDHの原因遺伝子を解明することが目的である。先行してDDH患者230症例についてジャポニカアレイでの解析を既に行っている。今後DDH 患者200症例の追加解析を目標とする。ジャポニカアレイを用いて日本人に特異的な約66万箇所のSNPの中で、DDH発症と相関するSNPを有する遺伝子群を解析する。また、約30億塩基の全ゲノム構造をインピュテーションすることでDDH疾患感受性遺伝子の網羅的な探索を行う。健常群は東北大学東北メディカル・メガバンクの2947人のデータを利用予定である。p値が1x10-7以下の疾患感受性が疑われるSNPに関して，ジャポニカアレイ検体とは異なるDDH患者200症例のゲノムDNAを対象にして、Taqman probeを用いたリアルタイムPCRでレプリケーションスタディを行い、ジャポニカアレイで同定された新規DDH関連SNPの発現について検証する。 DDHの網羅的ゲノム解析で探索されたDDH疾患感受性遺伝子について、家族歴・環境因子、画像での重症度評価、手術治療などの臨床情報と相関解析を行うことで重症化関連遺伝子を解明する。
Elucidation of mechanisms of bone formation; primary ciliary formation by protein 4.1G

Saito Masaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Osteogenesis imperfecta is one of the designated intractable diseases, and no effective therapeutic method has been developed. Discovering the mechanisms of osteogenesis connects to the development of a novel therapeutic method. In the present study, I found that a membrane scaffold protein 4.1G contributed to the formation of primary cilia in the osteoprogenitor cells, resulting in potentiation of the ciliary hedgehog signaling and differentiation to osteoblasts. By using isolated tibia from 4.1G-knockout mice, I further found that 4.1G regulates osteogenesis in both males and females from the embryonic to neonatal period and in the only females at puberty.
Effects of reducing stress shielding and fracture healing acceleration by orthopaedic implants of TiNbSn alloy with low Young's modulus

Mori Yu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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The suppression effect of stress shielding was investigated in an experimental hip joint prosthesis model using a low elastic modulus titanium alloy TiNbSn. Finite element analysis confirmed the improvement of load-stress imbalance, and the suppression of bone atrophy in the canine low elastic modulus titanium alloy artificial hip joint model was clarified. We also investigated the effect of low modulus titanium alloy TiNbSn on promoting bone healing by making a metal plate and examining CT images of actual bone tissue, hard tissue specimens, and bone strength after healing in a rabbit tibial osteotomy model. The effect of TiNbSn alloy on early bone healing and improvement of bone strength after healing was confirmed in comparison with Ti6Al4V alloy.
Elucidation of the causative gene of developmental dysplasia of the hip using Japonica array

Chiba Daisuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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Developmental dysplasia of the hip (DDH) is common in Japanese with a frequency of approximately 0.3%. About 80% of patients with osteoarthritis of the hips (OA) are caused by DDH. The pain and deformity of the hip joint make walking difficult and the activities of daily living are significantly impaired. Prevention of OA is important. The purpose of this study is to elucidate the causative gene of DDH using Japonica array, which is a genome-wide association analysis tool optimized for Japanese. The data of healthy subjects and those of DDH patients were compared. As a result of Japonica array analysis, 157 SNPs with a significantly high frequency in DDH were identified. In particular, it was suggested that the ubiquinol-cytochrome c reductase complex chaperone (UQCC) 1 gene is involved in the development of DDH in Japanese.
Study on titanium dioxide with environmental purification and biocompatibility

Masahashi Naoya, MIZUKOSHI YOSHITERU, SEMBOSHI SATOSHI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2015/04/01 - 2019/03/31

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In order to impart osteoconductivity to a low Young's modulus TiNbSn alloy which suppresses stress shielding, anodic oxidation was applied in a sulfuric acid electrolyte under high voltage application. The crystallinity of the titanium oxide formed on the surface was controlled under the electrolytic conditions, and the osteoconductivity was confirmed in the TiNbSn alloy with high crystallinity TiO2. The pull-out strength of anodized TiNbSn alloy increased significantly as compared with the untreated material after in vivo test, and it was considered that the adhesion with the TiNbSn alloy was strengthened by the new bone tissue formed on the TiO2. TEM-EDX analysis after in vitro test confirmed the penetration of large amounts of Ca and P into porous TiO2, and proposed a model that osteoconductivity is attributed to the bioactive TiO2 loading and penetration of bone constituent elements into porous TiO2.
Effects of total hip arthroplasty stem composed of Ti-Nb-Sn alloy with low Young's modulus on the improvement of stress shielding

Mori Yu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Total hip arthroplasty stems of Ti6Al4V alloy and TiNbSn alloy were produced with the same design. It is confirmed that the Young’s modulus of the TiNbSn alloy stem is 55 GPa. The modulus of elasticity of the Ti6Al4V alloy stem was 110 GPa. Total hip arthroplasties were performed on 10 kg male Beagle dogs. We plan to observe the bone formation around the stem by the CT image and evaluate histological analyses of bone tissue around the stems at 1 year after surgery. We compare the results of stress analyses using FEM with CT images and histological findings. We also assessed the effects of anodizing treatment of TiNbSn alloy on improvement of bone compatibility and of the low elasticity on bone union acceleration. In the rabbit tibia model and the mouse tibia model, improved bone synthesis in the fracture site was indicated in TiNbSn group compared with the stainless steel group or the Ti6Al4V group.
Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3-green fluorescent protein reporter mice

MORI Yu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2013/04/01 - 2015/03/31

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Fracture healing is a complex biological process involving the proliferation of mesenchymal progenitor cells, and chondrogenic, osteogenic and angiogenic differentiation. Here, we demonstrate Dickkopf-related protein 3 (Dkk3) expression in periosteal cells using Dkk3-green fluorescent protein (Dkk3-GFP) reporter mice. We found that proliferation of mesenchymal progenitor cells began in the periosteum, involving Dkk3-positive cell proliferation near the fracture site. In addition, Dkk3 was expressed in fibrocartilage cells with and smooth muscle alpha actin and Col3.6 in the early phase of fracture healing as a cell marker of fibrocartilage cells. Dkk3 was not expressed in mature chondrogenic cells or osteogenic cells. Transient expression of Dkk3 had disappeared in the late phase of fracture healing except in the superficial periosteal area of fracture callus. The Dkk3 expression pattern differed in newly formed type IV collagen-positive blood vessels and the related avascular tissue.

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