東北大学研究者紹介

ナルシマ　タカユキ

成島　尚之

Takayuki Narushima

所属

大学院工学研究科　材料システム工学専攻　生体材料システム学講座（医用材料工学分野）

職名

教授

学位

博士（工学）（東北大学）

researchmap

https://researchmap.jp/read0168413

J-GLOBAL ID

200901010849505436

経歴 7

2023年4月～継続中

東北大学レアメタル・グリーンイノベーション研究開発センター　センター長
2007年4月～継続中

東北大学大学院工学研究科材料システム工学専攻　教授
2004年6月～ 2007年3月

東北大学先進医工学研究機構　教授
1997年4月～ 2004年6月

東北大学大学院工学研究科　助教授
1998年3月～ 1999年3月

カリフォルニア大学（文部省在外研究員）　リサーチフェロー
1994年12月～ 1997年3月

東北大学工学部　助教授
1987年4月～ 1994年11月

東北大学工学部　助手

︎全件表示 ︎最初の5件までを表示

学歴 2

東北大学　工学研究科　材料物性工学専攻

～ 1987年3月31日
東北大学　工学部　金属工学科

～ 1985年3月31日

委員歴 33

一般社団法人日本鉄鋼協会　代議員

2024年4月～継続中
日本チタン学会　副会長

2021年4月～継続中
一般社団法人日本歯科理工学会　東北支部代議員

2018年4月～継続中
チタン世界会議国際組織委員会　日本代表委員

2015年8月～継続中
一般社団法人日本鉄鋼協会, JABEE委員会　委員

2015年4月～継続中
日本チタン協会　産学連携委員会学側代表

2010年4月～継続中
日本バイオマテリアル学会　評議員

2006年4月～継続中
公益社団法人日本金属学会　理事

2021年4月～ 2023年3月
軽金属学会　軽金属誌編集委員

2010年4月～ 2023年3月
日本バイオマテリアル学会　理事

2012年4月～ 2022年3月
一般社団法人日本技術者教育認定機構　理事

2019年4月～ 2021年4月
一般社団法人日本鉄鋼協会, JABEE委員会　委員長

2018年4月～ 2020年3月
一般社団法人日本技術者教育認定機構　認定・審査調整委員会委員

2018年4月～ 2020年3月
一般社団法人日本鉄鋼協会　理事

2018年4月～ 2020年3月
軽金属学会研究委員会「チタンの準安定相・析出相研究部会」　部会長

2015年6月～ 2020年3月
軽金属学会　東北支部支部長

2015年4月～ 2019年3月
日本金属学会「チタン製造プロセスと材料機能」研究会　代表者

2014年4月～ 2019年3月
一般社団法人日本鉄鋼協会, JABEE委員会　副委員長

2016年4月～ 2018年3月
日本金属学会第4分科会　副委員長

2015年4月～ 2017年3月
次世代構造部材創製・加工技術開発総合技術委員会　委員

2013年10月～ 2016年3月
日本金属学会第4分科会　委員長

2011年4月～ 2015年3月
軽金属学会　理事

2011年4月～ 2015年3月
軽金属学会編集員会　幹事

2011年4月～ 2015年3月
日本金属学会第4分科会　副委員長

2009年4月～ 2011年3月
日本金属学会分科会　幹事

2005年4月～ 2009年3月
日本金属学会会誌・欧文誌　編集委員

2002年4月～ 2006年3月
日本金属学会分科会　委員

2003年4月～ 2005年4月
日本金属学会会報「まてりあ」　編集委員

2003年4月～ 2005年3月
(社)日本鉄鋼協会　ノーベルプロセッシングフォーラム幹事

2000年4月～ 2003年3月
(社)日本鉄鋼協会　東北支部幹事

2000年4月～ 2002年3月
日本セラミックス協会　JABEE対応学部カリキュラム小委員会委員

2000年10月～ 2001年3月
日本金属学会会報「まてりあ」　編集委員

1999年4月～ 2001年3月
日本金属学会　まてりあ改革検討小委員会委員

2003年6月～

︎全件表示 ︎最初の5件までを表示

所属学協会 9

一般社団法人日本チタン協会

2012年4月～継続中
米国TMS

2010年1月～継続中
一般社団法人日本歯科理工学会

2007年4月～継続中
一般社団法人軽金属学会

2007年4月～継続中
日本バイオマテリアル学会

2005年4月～継続中
一般社団法人日本鉄鋼協会

1990年4月～継続中
米国セラミックス協会

1989年1月～継続中
公益社団法人日本金属学会

1987年4月～継続中
公益社団法人日本セラミックス協会

1987年1月～継続中

︎全件表示 ︎最初の5件までを表示

研究キーワード 5

界面反応
リン酸カルシウム
Co-Cr合金
チタン合金
生体材料

研究分野 4

ナノテク・材料 / 構造材料、機能材料 /
ライフサイエンス / 生体材料学 /
ライフサイエンス / 生体医工学 /
ナノテク・材料 / 材料加工、組織制御 /

受賞 37

ポスター賞

2019年12月　第2回日本金属学会第7分野講演会「金属系バイオマテリアルサイエンスの新展開(II)」　実用歯科用チタン合金表面に作製した炭素・窒素含有TiO2膜の可視光応答性評価
優秀ポスター賞

2019年10月　日本バイオマテリアル学会東北ブロック　ステント用Co-Cr-W-Ni合金の結晶粒粒微細化と機械的特性
東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会優秀ポスター賞

2019年10月　日本バイオマテリアル学会東北ブロック　二段階熱酸化によるチタンへの炭素・窒素含有TiO2膜の作製と可視光応答型光触媒活性
平成30年度軽金属希望の星賞

2019年3月　軽金属学会　二段階熱酸化法による実用Ti合金表面への光活性抗菌機能化TiO2膜作製と評価
東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会優秀ポスター賞

2018年8月　日本バイオマテリアル学会東北ブロック　二段階熱酸化による歯科用Ti合金へのTiO2膜作製と抗菌能評価
東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会「バイオマテリアル研究東北地区交流会」優秀ポスター賞

2017年9月26日　バイオマテリアル研究東北地区
Poster Presentation Award

2017年6月28日　Joint Symposium on Materials Science and Engineering for the 21st Century
Poster Presentation Award

2017年3月21日　2017 Annual Meeting of Excellent Graduate Schools for Materials Integration Center and Materials Science Center
Poster Presentation Award

2016年3月19日　2016 Japan-Russia Joint Seminar “Advanced Materials Synthesis Process and Nanostructure” in conjunction with 2015 Annual Meeting of Excellent Graduate Schools for “Materials Integration Center” and “Materials Science Center”
優秀ポスター賞

2015年9月　日本金属学会
優秀ポスター発表賞

2015年5月　軽金属学会
Best Oral Presentation

2014年11月　Bioceramics26
優秀ポスター賞

2014年9月　日本金属学会
Award of the 2nd poster presentation prize

2014年9月　6th International Workshop on Advanced Ceramics
第12回軽金属功績賞

2014年5月17日　（一社）軽金属学会
Outstanding Presentation Award

2013年12月　International Symposium on Eco Topia Science 2013(ISETS13)
優秀講演発表賞

2013年5月　粉体粉末冶金協会
日本セラミックス協会東海支部学術研究発表会優秀発表賞

2012年12月　日本セラミックス協会東海支部
第29回日本チタン協会技術賞

2012年11月19日　日本チタン協会
ISAEM2012 Best Poster Presentation

2012年11月6日　ISAEM-2012
Best Poster Award

2009年12月　KINKEN-WAKATE2009
第8回日本金属学会東北支部研究発表大会奨励賞

2009年12月　日本金属学会東北支部
Best Presentation Award

2009年9月　Interdisciplinary Science of Nanomaterials
ISAEM-2008 Best Poster Presentation

2008年11月　ISAEM-2008
第10回日本金属学会優秀ポスター賞

2008年3月26日　日本金属学会
第66回日本金属学会功績賞

2008年3月26日　(社)日本金属学会　材料化学部門
第６回軽金属躍進賞

2007年11月10日　(社)軽金属学会　軽金属に関する学術研究および技術開発
第6回日本金属学会東北支部研究発表大会ポスター優秀賞

2007年11月　日本金属学会東北支部
第一回東北大学金属材料研究所附属金属ガラス総合研究センター共同利用研究最優秀賞

2007年5月21日　東北大学金属材料研究所附属金属ガラス総合研究センター
平成19年度学術記念賞（西山記念賞）

2007年3月27日　(社)日本鉄鋼協会　材料製造プロセスの基礎的研究
傾斜機能材料研究会2006年度研究奨励賞

2006年6月　傾斜機能材料研究会
第5回日本金属学会優秀ポスター賞

2005年9月　日本金属学会
第1回日本金属学会優秀ポスター賞

2003年10月　日本金属学会
第5回金属学会奨励賞

1995年12月　(社)日本金属学会　新素材の高温における物理化学
第65回工学研究奨励賞

1995年10月　(財)服部報公会　ラマン分光法により高温酸化皮膜形成過程のその座観察
第34回原田研究奨励賞

1994年7月　(財)金属研究助成会　シリコン其セラミックスの高温酸化
第15回本多記念研究奨励賞

1994年2月　(財)本多記念会　シリコン其セラミックスの高温酸化

︎全件表示 ︎最初の5件までを表示

論文 261

Probing plastic deformation-related properties in static recrystallized Co-Cr-Fe-Ni-Mo alloy for biomedical applications 査読有り

K. Hiyama, K. Ueki, K. Ueda, T. Narushima

Mat. Sci. Eng. A　2024年5月
Systematic study on the microstructures of biomedical Co-20Cr-15W-10Ni alloys with carbon contents ranging from 0 to 0.2 mass pct 査読有り

S.S. Friandani, K. Ueda, T. Narushima

Metall. Mater. Trans. B　55　1011-1024　2024年3月

DOI： 10.1007/s11661-024-07300-3 　
Improvement of Work-Hardening Behavior of Co-Cr-W-Ni Alloy by Adding Mn/Fe for Balloon-Expandable Stents 査読有り

Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Key Engineering Materials　967　115-120　2023年12月5日
出版者・発行元：Trans Tech Publications, Ltd.
DOI： 10.4028/p-ervq7v 　

eISSN：1662-9795

詳細を見る詳細を閉じる

The Co-20Cr-15W-10Ni (CCWN, mass%) alloy, registered as American society of testing and materials (ASTM) F90, has been widely used as a balloon-expandable stent because of its excellent balance between its mechanical properties and corrosion resistance. To realize a less invasive stent placement, the stent diameter must be reduced, which implies that the stent strut thickness must be reduced. As such, the CCWN alloy must be high in strength and ductility while maintaining a low yield stress to facilitate the expansion and suppression of stent recoil. In this study, we focus on the effects of the adding Mn/Fe on the microstructure, mechanical properties, and corrosive properties of CCWN alloys. A 6 mass% Mn-added CCWN alloy with a grain size of approximately 20 μm prepared in this study exhibits excellent balance between tensile strength and ductility. In addition, it exhibits a lower yield stress while maintaining a high tensile strength compared with the ASTM F90 alloy. Meanwhile, a 6 mass% Fe-added CCWN alloy exhibits a higher ductility compared with the ASTM F90 alloy. The addition of Mn or Fe to the CCWN alloy increases the stacking fault energy of the alloy and suppresses strain-induced martensitic transformation during plastic deformation, thus improving the ductility of the alloy. Results of polarization tests show that the 6 mass% Mn-or Fe-added CCWN alloys exhibit the same corrosion current density as the ASTM F90 alloy. Mn-added Co-Cr-W-Ni alloys are suitable for use in balloon-expandable stents.
Visible-light antibacterial activity of carbon and nitrogen co-doped rutile TiO2 films 招待有り査読有り

R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, H. Kanetaka, T. Mokudai, T. Narushima

Thin Solid Films　780　139944　2023年8月

DOI： 10.1016/j.tsf.2023.139944 　
Electronic structure analysis of light-element-doped anatase TiO2 using all-electron GW approach 査読有り

T. Ishikawa, R. Sahara, K. Ohno, K. Ueda, T. Narushima

Comput. Mater. Sci.　220　112059　2023年2月

DOI： 10.1016/j.commatsci.2023.112059 　
Special Issue on Recent Research and Development in the Processing, Microstructure, and Properties of Titanium and Its Alloys

Mitsuo Niinomi, Masahiko Ikeda, Yoko Yamabe-Mitarai, Hideki Hosoda, Takuya Ishimoto, Sengo Kobayashi, Takao Hanawa, Takayuki Narushima, Takayoshi Nakano

Materials Transactions　64　(1)　1　2023年

DOI： 10.2320/matertrans.MPR2023901 　

ISSN：1345-9678
Improvement of mechanical properties of Co–Cr–W–Ni alloy tube suitable for balloon-expandable stent applications through heat treatment 査読有り

Shunsei Takeda, Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Materials Science and Engineering: A　862　144505-144505　2023年1月
出版者・発行元：None
DOI： 10.1016/j.msea.2022.144505 　

ISSN：0921-5093
Effect of niobium and oxygen contents on microstructure and mechanical properties of α+β-type Ti-(5–25)Nb-(0.5–1)O (mass%) alloys for biomedical applications 査読有り

K. Ueda, M. Omiya, K. Kato, H. Kanetaka, T. Narushima

Mater. Trans.　64　(1)　138-146　2023年1月

DOI： 10.2320/matertrans.MT-MLA2022020 　
Antibacterial properties of TiO2 layers formed by Au-sputtering and thermal oxidation of titanium under visible light 査読有り

T. Ueda, R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima

Mater. Trans.　63　(12)　155-164　2023年1月

DOI： 10.2320/matertrans.MT-MLA2022006 　

ISSN：1345-9678
Tough yet flexible superelastic alloys meet biomedical needs 招待有り査読有り

X. Xu, T. Odaira, S. Xu, K. Hirata, T. Omori, K. Ueki, K. Ueda, T. Narushima, M. Nagasako, R. Kainuma, S. Harjo, T. Kawasaki, L. Bodnárová, P. Sedlák, H. Seiner

Advanced Materials & Processes　180　(7)　35-37　2022年10月
出版者・発行元：None
ISSN：0882-7958

eISSN：2161-9425
Flexible and Tough Superelastic Co–Cr Alloys for Biomedical Applications 国際誌査読有り

Takumi Odaira, Sheng Xu, Kenji Hirata, Xiao Xu, Toshihiro Omori, Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima, Makoto Nagasako, Stefanus Harjo, Takuro Kawasaki, Lucie Bodnárová, Petr Sedlák, Hanuš Seiner, Ryosuke Kainuma

Advanced Materials　34　(27)　2202305-2202305　2022年7月
出版者・発行元：Wiley
DOI： 10.1002/adma.202202305 　

ISSN：0935-9648

eISSN：1521-4095

詳細を見る詳細を閉じる

The demand for biomaterials has been increasing along with the increase in the population of elderly people worldwide. The mechanical properties and high wear resistance of metallic biomaterials make them well-suited for use as substitutes or as support for damaged hard tissues. However, unless these biomaterials also have a low Young's modulus similar to that of human bones, bone atrophy inevitably occurs. Because a low Young's modulus is typically associated with poor wear resistance, it is difficult to realize a low Young's modulus and high wear resistance simultaneously. Also, the superelastic property of shape-memory alloys makes them suitable for biomedical applications, like vascular stents and guide wires. However, due to the low recoverable strain of conventional biocompatible shape-memory alloys, the demand for a new alloy system is high. The novel body-centered-cubic cobalt-chromium-based alloys in this work provide a solution to both of these problems. The Young's modulus of <001>-oriented single-crystal cobalt-chromium-based alloys is 10-30 GPa, which is similar to that of human bone, and they also demonstrate high wear and corrosion resistance. They also exhibit superelasticity with a huge recoverable strain up to 17.0%. For these reasons, the novel cobalt-chromium-based alloys can be promising candidates for biomedical applications.
Analysis of the oxidation and nitridation of Ti-17 (Ti-5Al-2Sn-2Zr-4Mo-4Cr) alloys with added Si in atmospheric heating 査読有り

T. Narushima, S. Suzuki, K. Ueda, S.K. Bhattacharya, R. Sahara

ISIJ Int.　62　(7)　1512-1521　2022年7月

DOI： 10.2355/isijinternational.ISIJINT-2022-053 　
Electronegativity difference as a descriptor for oxidation inhibiting effect of alloying element during early stages of titanium oxidation 国際誌国際共著査読有り

K. Kohli, S. Bhattacharya, K. Ueda, T. Narushima, R. Sahara, P. Ghosh

Langmuir　38　(4)　1448-1457　2022年1月
出版者・発行元：None
DOI： 10.1021/acs.langmuir.1c02633 　

ISSN：0743-7463

eISSN：1520-5827
Development of Low-Yield Stress Co–Cr–W–Ni Alloy by Adding 6 Mass Pct Mn for Balloon-Expandable Stents 査読有り

Soh Yanagihara, Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Metallurgical and Materials Transactions A　52　(9)　4137-4145　2021年7月7日
出版者・発行元：None
DOI： 10.1007/s11661-021-06374-7 　

ISSN：1073-5623

eISSN：1543-1940
Effect of Precursor Deficiency Induced Ca/P Ratio on Antibacterial and Osteoblast Adhesion Properties of Ag-Incorporated Hydroxyapatite: Reducing Ag Toxicity 査読有り

Ozkan Gokcekaya, Celaletdin Ergun, Thomas J. Webster, Abdurrahman Bahadir, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano

Materials　14　(12)　3158-3158　2021年6月8日
出版者・発行元：None
DOI： 10.3390/ma14123158 　

eISSN：1996-1944

詳細を見る詳細を閉じる

Ag-containing hydroxyapatite (HA) can reduce risks associated with bacterial infections which may eventually require additional surgical operations to retrieve a failed implant. The biological properties of HA in such applications are strongly affected by its composition in terms of dopants as well as Ca/P stoichiometry, which can be easily controlled by altering processing parameters, such as precursor concentrations. The objective of this in vitro study was to understand the effect of variations in HA precursor solutions on antibacterial properties againstEscherichia coli(E. coli) and for promoting osteoblast (bone-forming cell) adhesion on Ag incorporated HA (AgHA) which has not yet been investigated. For this, two groups of AgHAs were synthesized via a precipitation method by adjusting precursor reactants with a stoichiometric value of 1.67, being either (Ca + Ag)/P (Ca-deficient) or Ca/(P + Ag) (P-deficient), and were characterized by XRD, FTIR, and SEM-EDS. Results showed that Ag+ incorporated into the Ca2+ sites was associated with a corresponding OH− vacancy. Additional incorporation of CO32− into PO43− sites occurred specifically for the P-deficient AgHAs. While antibacterial properties increased, osteoblast adhesion decreased with increasing Ag content for the Ca-deficient AgHAs, as anticipated. In contrast, significant antibacterial properties with good osteoblast behavior were observed on the P-deficient AgHAs even with a lower Ag content, owing to carbonated HA. Thus, this showed that by synthesizing AgHA using P-deficient precursors with carbonate substitution, one can keep the antibacterial properties of Ag in HA while reducing its toxic effect on osteoblasts.
Unique crystallographic texture formation in Inconel 718 by laser powder bed fusion and its effect on mechanical anisotropy 査読有り

O. Gokcekaya, T. Ishimoto, S. Hibino, J. Yasutomi, T. Narushima, T. Nakano

Acta Mater.　212　116876　2021年4月

DOI： 10.1016/j.actamat.2021.116876 　

ISSN：1359-6454
Improvement of mechanical properties relating to microstructure for biomedical Co–Cr–W–Ni alloys with addition of Mn and Si 査読有り

K. Ueki, S. Yanagihara, K. Ueda, M. Nakai, T. Nakano, T. Narushima

Mater. Trans.　62　(2)　229-238　2021年2月
出版者・発行元：None
DOI： 10.2320/matertrans.MT-M2020300 　

ISSN：1345-9678

eISSN：1347-5320
Improvement of Strength and Ductility by Combining Static Recrystallization and Unique Heat Treatment in Co-20Cr-15W-10Ni Alloy for Stent Application

Kosuke Ueki, Soh Yanagihara, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Materials Science Forum　1016　1503-1509　2021年1月
出版者・発行元：None
DOI： 10.4028/www.scientific.net/msf.1016.1503 　

ISSN：0255-5476

eISSN：1662-9752
Effect of scan length on densification and crystallographic texture formation of pure chromium fabricated by laser powder bed fusion 査読有り

O. Gokcekaya, T. Ishimoto, T. Todo, R. Suganuma, R. Fukushima, T. Narushima, T. Nakano

Crystals　11　(1)　9-14　2021年1月

DOI： 10.3390/cryst11010009 　

eISSN：2073-4352
Formation of carbon-added anatase-rich TiO2 layers on titanium and their antibacterial properties in visible light 国際誌査読有り

Takatoshi Ueda, Naoki Sato, Ryusuke Koizumi, Kyosuke Ueda, Koyu Ito, Kouetsu Ogasawara, Takayuki Narushima

Dental Materials　37　(2)　e37-e46　2021年1月
出版者・発行元：None
DOI： 10.1016/j.dental.2020.10.009 　

ISSN：0109-5641
Crystallographic orientation control of pure chromium via laser powder-bed fusion and improved high temperature oxidation resistance 査読有り

O. Gokcekaya, N. Hayashi, T. Ishimoto, K. Ueda, T. Narushima, T. Nakano

Additive Manufacturing　36　101624-101624　2020年10月
出版者・発行元：None
DOI： 10.1016/j.addma.2020.101624 　

ISSN：2214-8604
Development of α+β-type biomedical Ti-Nb alloys with high oxygen content 査読有り

K. Ueda, M. Omiya, Y. Hirose, T. Narushima

MATEC Web of Conferences　321　05003-05003　2020年10月
出版者・発行元：None
DOI： 10.1051/matecconf/202032105003 　

eISSN：2261-236X
Fabrication and bioresorbability of Ag- and Ta-containing amorphous calcium phosphate films formed on titanium substrates by RF magnetron sputtering 査読有り

J. Wu, K. Ueda, T. Narushima

MATEC Web of Conferences　321　05007-05007　2020年10月
出版者・発行元：None
DOI： 10.1051/matecconf/202032105007 　

eISSN：2261-236X
Predicting the parabolic rate constants of high-temperature oxidation of Ti alloys using machine learning 査読有り

S.Kr. Bhattacharya, R. Sahara, T. Narushima

Oxid. Met.　94　205-218　2020年6月

DOI： 10.1007/s11085-020-09986-3 　
Fabrication of Ag and Ta co-doped amorphous calcium phosphate coating films by radiofrequency magnetron sputtering and their antibacterial activity 査読有り

Jun Wu, Kyosuke Ueda, Takayuki Narushima

Materials Science and Engineering: C　109　110599-110599　2020年4月
出版者・発行元：Elsevier BV
DOI： 10.1016/j.msec.2019.110599 　

ISSN：0928-4931
Using HAADF-STEM for atomic-scale evaluation of incorporation of antibacterial Ag atoms in a β-tricalcium phosphate structure 査読有り

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano

Nanoscale　12　(31)　16596-16604　2020年
出版者・発行元：None
DOI： 10.1039/d0nr04208k 　

ISSN：2040-3364

eISSN：2040-3372
Precipitation during γ-ε phase transformation in biomedical Co-Cr-Mo alloys fabricated by electron beam melting 査読有り

K. Ueki, M. Kasamatsu, K. Ueda, Y. Koizumi, D. Wei, A. Chiba, T. Narushima

Metals　10　(1)　71-1-13　2020年1月

DOI： 10.3390/met10010071 　

eISSN：2075-4701
Overcoming the strength-ductility trade-off by the combination of static recrystallization and low-temperature heat treatment in Co-Cr-W-Ni alloy for stent application 査読有り

K. Ueki, S. Yanagihara, K. Ueda, M. Nakai, T. Nakano, T. Narushima

Mat. Sci. Eng. A　766　2019年9月
出版者・発行元：None
DOI： 10.1016/j.msea.2019.138400 　

ISSN：0921-5093

eISSN：1873-4936
Effect of nonmetallic inclusions on fatigue properties of superelastic Ti-Ni fine wire 査読有り

F. Yamashita, Y. Ide, S. Kato, K. Ueda, T. Narushima, S. Kise, K. Ishikawa, M. Nishida

Metals　9　(9)　999　2019年9月

DOI： 10.3390/met9090999 　

eISSN：2075-4701
Formation of photocatalytic active TiO2 layers on Ti-Nb alloys by two-step thermal oxidation 査読有り

S. Sado, T. Ueda, Y. Tokuda, N. Sato, K. Ueda, T. Narushima

Mater. Trans.　60　(9)　1814-1820　2019年9月

DOI： 10.2320/matertrans.ME201901 　
COX-2 Induces T cell accumulation and IFN-γ production during the development of chromium allergy 査読有り

R. Sitalaksmi, K. Ito, K. Ogasawara, Y. Suto, M. Itabashi, K. Ueda, N. Hirasawa, T. Narushima, S. Higuchi, N. Sato, N. Hendrijantini, U. Kresnoadi, K. Sasaki

Autoimmunity　52　(5-6)　228-234　2019年8月

DOI： 10.1080/08916934.2019.1662404 　

ISSN：0891-6934

eISSN：1607-842X
Deoxidation of Ti melt by newly developed two-step plasma arc melting process using hydrogen 査読有り

M. Watanabe, F. Sato, R. Abe, K. Ueda, D. Matsuwaka, F. Kudo, T. Narushima

Metall. Mater. Trans. B　50　(4)　1553-1558　2019年8月

DOI： 10.1007/s11663-019-01608-x 　
Visible-light responsible antibacterial activity of Au-incorporated TiO2 layers formed on Ti-(0–10)at%Au alloys by air oxidation 国際誌査読有り

T. Ueda, K. Ueda, K. Ito, K. Ogasawara, T. Mokudai, H. Kanetaka, Y. Niwano, T. Narushima

J. Biomed. Mater. Res. A　107　(5)　991-1000　2019年5月

DOI： 10.1002/jbm.a.36624 　
Antibacterial activity of Ag nanoparticle-containing hydroxyapatite powders in simulated body fluids with Cl ions 査読有り

O. Gokcekaya, K. Ueda, K. Ogasawara, T. Narushima

Mater. Chem. Phys.　223　473-478　2019年1月

DOI： 10.1016/j.matchemphys 　
Experimental and theoretical study of the effect of Si on the oxidative behavior of Ti-6Al-4V alloys 査読有り

Kodai Maeda, Satoshi Suzuki, Kyosuke Ueda, Tomonori Kitashima, Somesh Kr. Bhattacharya, Ryoji Sahara, Takayuki Narushima

J. Alloys Compd.　776　519-528　2019年1月

DOI： 10.1016/j.jallcom.2018.10.291 　

ISSN：0925-8388
Synchronous improvement in strength and ductility of biomedical Co–Cr–Mo alloy by unique low-temperature heat treatment 査読有り

K. Ueki, M. Abe, K. Ueda, M. Nakai, T. Nakano, T. Narushima

Mat. Sci. Eng. A　739　53-61　2019年1月
出版者・発行元：None
DOI： 10.1016/j.msea.2018.10.016 　

ISSN：0921-5093

eISSN：1873-4936
Mechanism of oxidation of pure and Si-segregated α-Ti surfaces 査読有り

S. K. Bhattacharya, R. Sahara, S. Suzuki, K. Ueda, T. Narushima

Appl. Surf. Sci.　463　686-692　2019年1月

DOI： 10.1016/j.apsusc.2018.08.253 　
Heterogeneous microstructures and corrosion resistance of biomedical Co-Cr-Mo alloy fabricated by electron beam melting (EBM) 査読有り

Daixiu Wei, Yuichiro Koizumi, Akihiko Chiba, Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima, Yusuke Tsutsumi, Takao Hanawa

Additive Manufacturing　24　103-114　2018年12月

DOI： 10.1016/j.addma.2018.09.006 　

eISSN：2214-8604

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© 2018 We have investigated the spatial distribution of microstructures of a Co-Cr-Mo alloy rod fabricated by Electron Beam Melting (EBM) method along built height. The topside of the rod is rich in γ-fcc phase and consists of fine grains with high local distortion density. The bottom part has an ε-hcp single phase and consists of relatively coarser grains with low local distortion density. The middle part of the rod consisted of the mixture of both phases. The mean grain size increases from 56 μm (at the top of the rod) to 159 μm (at the bottom), and is accompanied by a decrease in the γ-fcc phase fraction. On the other hand, a large number of precipitates including the main M 23 X 6 phase and minor phases (η-phase and π-phase) were observed. The area fraction of the precipitates increases gradually from 5.26% (at the top) to 8.73% (at the bottom), and the relative proportion of each phase fluctuates at different positions. The hardness of the top side is lower than that of the bottom side. As a result, the hardness of the samples, as well as the area fraction of precipitates formed in the samples, increases gradually from top to bottom of the rod, while corrosion resistance is uniformly high throughout the rod almost independently of the location. The mechanism behind the formation of phase distribution is discussed in terms of thermodynamic phase stability and kinetics of phase transformation accompanying the thermal history during the post-solidification process.
Microstructural Changes During Plastic Deformation and Corrosion Properties of Biomedical Co-20Cr-15W-10Ni Alloy Heat-Treated at 873 K 査読有り

Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science　49　(6)　2393-2404　2018年6月1日
出版者・発行元：Springer Boston
DOI： 10.1007/s11661-018-4597-0 　

ISSN：1073-5623

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Microstructural changes were observed during the plastic deformation of ASTM F90 Co-20Cr-15W-10Ni (mass pct) alloy heat-treated at 873 K (600 °C) for 14.4 ks, and analyzed by electron backscatter diffraction and in situ X-ray diffraction techniques. The obtained results revealed that the area fraction of the ε-phase (fε) in the as-received alloy was higher than that in the heat-treated alloy in the low-to-middle strain region (≤ 50 pct), whereas the fε of the heat-treated alloy was higher than that of the as-received alloy at the fracture point. During plastic deformation, the ε-phase was preferentially formed at the twin boundaries of the heat-treated alloy rather than at the grain boundaries. According to the transmission electron microscopy observations, the thin ε-phase layer formed due to the alloy heat treatment acted as the origin of deformation twinning, which decreased the stress concentration at the grain boundaries. The results of anodic polarization testing showed that neither the heat treatment at 873 K (600 °C) nor plastic deformation affected the alloy corrosion properties. To the best of our knowledge, this is the first study proving that the formation of a thin ε-phase layer during the low-temperature heat treatment of the studied alloy represents an effective method for the enhancement of the alloy ductility without sacrificing its strength and corrosion properties.
Effect of Si on the oxidation reaction of α-Ti (0001) surface: ab initio molecular dynamics study 査読有り

S. K. Bhattacharya, R. Sahara, K. Ueda, T. Narushima

Sci. Tech. Ad. Mater.　18　(1)　998-1004　2017年12月31日
出版者・発行元：None
DOI： 10.1080/14686996.2017.1403273 　

ISSN：1878-5514 1468-6996
First principles study of oxidation of Si segregated α-Ti(0001) surfaces 査読有り

S. K. Bhattacharya, R. Sahara, T. Kitashima, K. Ueda, T. Narushima

JPN. J. Appl. Phys.　56　(12)　125701-1-125701-7　2017年12月
出版者・発行元：None
DOI： 10.7567/JJAP.56.125701 　

ISSN：0021-4922

eISSN：1347-4065
In vitro performance of Ag-incorporated hydroxyapatite and its adhesive porous coatings deposited by electrostatic spraying 査読有り

Ozkan Gokcekaya, Thomas J. Webster, Kyosuke Ueda, Takayuki Narushima, Celaletdin Ergun

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　77　556-564　2017年8月
出版者・発行元：ELSEVIER SCIENCE BV
DOI： 10.1016/j.msec.2017.03.233 　

ISSN：0928-4931

eISSN：1873-0191

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Bacterial infection of implanted materials is a significant complication that might require additional surgical operations for implant retrieval. As an antibacterial biomaterial, Ag-containing hydroxyapatite (HA) may be a solution to reduce the incidences of implant associated infections. In this study, pure, 0.2 mol% and 0.3 mol% Ag incorporated HA powders were synthesized via a precipitation method. Colloidal precursor dispersions prepared from these powders were used to deposit porous coatings onto titanium and stainless steel substrates via electrostatic spraying. The porous coating layers obtained with various deposition times and heat treatment conditions were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Scratch tests were conducted to assess the adhesion strength of the coating. Antibacterial activity of Ag-incorporated HA was tested towards Escherichia coli (E. coli) at various incubation times. Osteoblast adhesion on Ag-incorporated HA was evaluated to assess biocompatibility. Improvement in adhesion strength of the coating layer was observed after the heat treatment process due to mutual ionic diffusion at the interface. The Ag-incorporated HA killed all viable E. coli after 24 h of incubation, whereas no antibacterial activity was detected with pure HA. In addition, in vitro cell culture tests demonstrated osteoblast adhesion similar to pure HA, which indicated good cytocompatibility. In summary, results of this study provided significant promise for the future study of Agincorporated HA for numerous medical applications. (C) 2017 Elsevier B.V.All rights reserved.
Effect of heat treatment and alloying elements on precipitation and surface behavior of Co-Cr-Mo alloys 査読有り

Alfirano, A. Milandia, T. Narushima

ARPN Journal of Engineering and Applied Sciences　12　(12)　3808-3812　2017年6月15日
In vitro evaluation of Ag-containing calcium phosphates: Effectiveness of Ag-incorporated β-tricalcium phosphate 査読有り

O. Gokcekaya, K. Ueda, K. Ogasawara, H. Kanetaka, T. Narushima

Mater. Sci. Eng. C　75　926-933　2017年6月
出版者・発行元：None
DOI： 10.1016/j.msec.2017.02.059 　

ISSN：0928-4931

eISSN：1873-0191
TRAV7-2*02 Expressing CD8⁺ T Cells Are Responsible for Palladium Allergy. 国際誌査読有り

Yuri Takeda, Yoshiko Suto, Koyu Ito, Wataru Hashimoto, Tadashi Nishiya, Kyosuke Ueda, Takayuki Narushima, Tetsu Takahashi, Kouetsu Ogasawara

International journal of molecular sciences　18　(6)　1162-1-1162-12　2017年5月31日

DOI： 10.3390/ijms18061162 　

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While metallic biomaterials have led to an improvement in the quality of life, metal allergies, especially to palladium (Pd), has caused a recent increase in allergic patients. Metal allergy is known to be a T cell-mediated delayed-type hypersensitivity (DTH); however, the pathogenic T cell subsets and the specific T cell receptor (TCR) have not been identified. Therefore, we attempted to identify the pathogenic T cells responsible for Pd allergy. We found that activating CD8⁺ T cells significantly increased and that the TRAV (TCRα variable) 7-2*02 chain skewed in Pd allergic mice. Furthermore, adoptive transfer experiments revealed that in vitro-cultured Pd-stimulated antigen presenting cells (APCs) function as memory APCs with recipient mice developing Pd allergy and that the frequency of TRAV7-2*02 increases the same as conventional Pd allergic mice. In contrast, neither proliferation of CD8⁺ T cells nor increasing of TRAV7-2*02 was observed in major histocompatibility complex I (MHC I)-deficient Pd-APCs transferred to mice. Taken together, we revealed that TRAV7-2*02-expressing CD8⁺ T cells are the pathogenic T cells for the development of Pd allergy. We also identified the CDR3 consensus motif of pathogenic TCRs as CAAXSGSWQLIF in TRAV7-2*02/TRAJ (TCRα junction)22*01 positive cells. These results suggest that the specific TCRs represent novel targets for the development of diagnostics and treatments for metal allergy.
Ceramic coating of Ti and its alloys using dry processes for biomedical applications 査読有り

T. Ueda, N. Kondo, S. Sado, O. Gokcekaya, K. Ueda, K. Ogasawara, T. Narushima

Interface Oral Health Science 2016, Innovative Research on Biosis-Abiosis Intelligent Interface　23-34　2017年1月8日

DOI： 10.1007/978-981-10-1560-1_2 　
Development and performance of low-cost beta-type Ti-based alloys for biomedical applications using Mn additions 査読有り

P.F. Santos, M. Niinomi, H. Liu, M. Nakai, K. Cho, T. Narushima, K. Ueda, N. Ohtsu, M. Hirano, Y. Itoh

Interface Oral Health Science 2016, Innovative Research on Biosis-Abiosis Intelligent Interface　229-245　2017年1月8日

DOI： 10.1007/978-981-10-1560-1_19 　
In vitro properties of Ag-containing calcium phosphates 査読有り

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima, Kouetsu Ogasawara, Hiroyasu Kanetaka

Ceramic Engineering and Science Proceedings　37　(4)　87-93　2017年
出版者・発行元：American Ceramic Society
DOI： 10.1002/9781119321682.ch10 　

ISSN：0196-6219

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Infections caused by implants used for bone replacement often lead to revision surgery and delayed recovery. The use of implant materials that exhibit antibacterial activity is an effective method for decreasing the rate of such infections. Ag is widely used for fabricating implants because of its antibacterial properties. In this study, calcium phosphate powders with various Ag contents were synthesized by a precipitation method and sintered at 1373 K in air for 24 h to form compacts of biphasic hydroxyapatite (HA)/tricalcium phosphate (β-TCP) or single phase β-TCP. The in vitro dissolution test of sintered compacts was conducted in Tris-HCl solution (Tris-hydroxymethyl-aminomethane). An Escherichia coli suspension was used for the antibacterial tests. Cytotoxicity of sintered compacts toward V79 fibroblasts was evaluated. During the in vitro dissolution test of Ag-containing calcium phosphate sintered compacts, the amount of Ag ions in Tri-HCl solution initially increased and then decreased because of AgCl precipitation. The antibacterial activity of Ag-incorporated single β-TCP was clearly observed, and higher than that of the biphasic HA/β-TCP. No cytotoxicity toward V79 fibroblasts was detected for Ag-incorporated β-TCP sintered compacts.
Effects of Mo Addition on the Mechanical Properties and Microstructures of Ti-Mn Alloys Fabricated by Metal Injection Molding for Biomedical Applications 査読有り

Pedro Fernandes Santos, Mitsuo Niinomi, Ken Cho, Huihong Liu, Masaaki Nakai, Takayuki Narushima, Kyosuke Ueda, Yoshinori Itoh

MATERIALS TRANSACTIONS　58　(2)　271-279　2017年
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.M2016286 　

ISSN：1345-9678

eISSN：1347-5320

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Ti-Mn alloys fabricated by metal injection molding (MIM) show promising performance for biomedical applications, but their low ductility (caused by high O content and the presence of pores and carbides) requires improvement. Previously, the addition of Mo to cold crucible levitation melted (CCLM) Ti-Mn alloys efficiently improved the ductility of those alloys by promoting mechanical twinning. In the present study, Mo was added to Ti-Mn alloys fabricated by MIM. Unlike fabrication by CCLM, fabrication by MIM can produce alloys with a smaller grain size, and also introduce microstructures such as pores and Ti carbides. Thus, in order to investigate how Mo addition interacts with these typical MIM features, four alloys for biomedical applications were fabricated by MIM: Ti-5Mn-3Mo (TMM-53), Ti-5Mn-4Mo (TMM-54), Ti-6Mn-3Mo (TMM-63), and Ti-6Mn-4Mo (TMM-64). Their microstructures, mechanical properties, and tensile deformation mechanisms were evaluated. Their hardness values range from 312-359 HV, and their Young s modulus values range from 84-88 GPa; both the Vickers hardness and Young s modulus show little variation among the alloys. Although the alloys show fracture features associated with a predominantly ductile fracture mode and Mo addition successfully promotes mechanical twinning in TMM-54, the elongation of these alloys is still critically low. Compared to the TMM alloys fabricated by CCLM, the TMM alloys fabricated by MIM show slightly lower hardness and Young s modulus, and comparable tensile strength, with their low elongation remaining inadequate for such applications. In particular, TMM-63 shows the best combination of mechanical properties among the present alloys, with an elongation of 4% and an ultimate tensile strength of 1145 MPa.
Preparation of orthophosphate glasses in the MgO–CaO–SiO2–Nb2O5–P2O5 system 査読有り

S Lee, K Ueda, T Narushima, T Nakano, T Kasuga

Bio-Medical Materials and Engineering　28　(1)　23-30　2017年
出版者・発行元：None
DOI： 10.3233/BME-171652 　

ISSN：0959-2989

eISSN：1878-3619
Removal of Oxygen in Ti-Si Melts by Arc-Melting 査読有り

Masahito Watanabe, Fumiya Sato, Kyosuke Ueda, Daisuke Matsuwaka, Takayuki Narushima

MATERIALS TRANSACTIONS　58　(4)　613-618　2017年
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.M2017003 　

ISSN：1345-9678

eISSN：1347-5320

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Oxygen removal from Ti-Si melts (Si: 9.1-30 mass%) during arc melting was investigated. High-purity Si was added to either Ti with a high oxygen content (High O Ti, O: 1.6 mass%) or commercially pure Ti (CP Ti, O: 0.104 mass%) melted under Ar or He gasfiow conditions at atmospheric pressure. At Si additions of 23 mass% and 30 mass%, the oxygen content of the Ti-Si ingots decreased. After melting, Si and amorphous SiO2 powders were observed in the chamber, which suggested that the oxygen in the melts was removed in the form of SiO gas. The oxygen content of the Ti-Si ingots after melting varied as a function of position within the ingot; the residual oxygen content was lowest in the top section of the ingots and highest in the bottom section. Under the Ar gasfiow, the oxygen content of the High O Ti-30Si ingot decreased to 0.136 mass% and 0.609 mass% in the top and center sections of the ingot, respectively; similarly, the oxygen content of the CP Ti-30Si ingot decreased to 0.030 mass% and 0.051 mass% in the top and center sections, respectively. After melting under He gasfiow, the oxygen contents of the CP Ti-30Si ingot in the top, center, and bottom sections were 0.020 mass%, 0.021 mass%, and 0.029 mass%, respectively. Better uniformity of oxygen distribution in the ingots was achieved under the He gasfiow than under the Ar gasfiow because the melted region is extended in the depth direction by using He gas. During melting, no significant evaporation of Ti and Si occurred, which is an advantage of arc melting that operates at atmospheric pressure over electron beam melting that occurs in vacuum.
Microstructure and mechanical properties of an α+β type Ti-4V-0.6O alloy 査読有り

M. Omiya, K. Ueda, T. Narushima

Mater. Trans.　58　(9)　1250-1256　2017年
出版者・発行元：None
DOI： 10.2320/matertrans.L-M2017825 　

ISSN：1345-9678

eISSN：1347-5320
TiO2 layers on Ti-Au alloy formed by two-step thermal oxidation and their photocatalytic activity in visible-light 査読有り

Takatoshi Ueda, Shota Sado, Kyosuke Ueda, Takayuki Narushima

MATERIALS LETTERS　185　290-294　2016年12月
出版者・発行元：ELSEVIER SCIENCE BV
DOI： 10.1016/j.matlet.2016.08.066 　

ISSN：0167-577X

eISSN：1873-4979

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Titania (TiO2) layers consisting of anatase and rutile phases were formed on Ti-4at%Au alloy surface, using a two-step thermal oxidation method of carburization followed by air oxidation. Au from the alloy was found in the formed TiO2 layer as metallic Au nanoparticles with diameter < 10 nm and dissolved Au3+. The visible-light photocatalytic activity of the TiO2 layer was evaluated by the degradation of stearic acid coating upon irradiation. Marked degradation of stearic acid was observed through the measured decrease in the water contact angle. Possible mechanisms of the visible-light photocatalytic activity are discussed. (C) 2016 Elsevier B.V. All rights reserved.
Improvement of microstructure, mechanical and corrosion properties of biomedical Ti-Mn alloys by Mo addition 査読有り

Pedro Fernandes Santos, Mitsuo Niinomi, Huihong Liu, Ken Cho, Masaaki Nakai, Adhitya Trenggono, Sebastien Champagne, Hendra Hermawan, Takayuki Narushima

MATERIALS & DESIGN　110　(2016)　414-424　2016年11月
出版者・発行元：ELSEVIER SCI LTD
DOI： 10.1016/j.matdes.2016.07.115 　

ISSN：0264-1275

eISSN：1873-4197

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In previous studies, Ti-Mn alloys showed promising performance for biomedical applications, but their elongation required improvement. In this study, Mo was added to Ti-Mn alloys to promote mechanical twinning and improve their ductility. Four alloys for biomedical applications were designed and fabricated by cold crucible levitation melting: Ti-5Mn-3Mo (TMM-53), Ti-5Mn-4Mo (TMM-54), Ti-6Mn-3Mo (TMM-63), and Ti-6Mn-4Mo (TMM-64). The microstructure, mechanical properties, tensile deformation mechanisms, and electrochemical corrosion properties of the alloys were evaluated. Their hardness ranges from 336 to 373 HV. Their Young's modulus ranges from 89 to 100 GPa. Both hardness and Young's modulus tend to decrease with decreasing amount of athermal omega phase, which is caused by increasing alloying elements contents. Mo addition improves the elongation of TMM-53 and TMM-54 by promoting twinning. Conversely, it increases the tensile strength of TMM-63 and TMM-64. Particularly, TMM-54 shows an elongation of 34% with an ultimate tensile strength (UTS) of 935 MPa. TMM-63 shows an elongation of 14% and a UTS of 1220 MPa, associated to the formation of deformation-induced to phase. Moreover, Mo addition decreases the corrosion rate of the Ti-Mn alloys to a level comparable to that of commercially-pure Ti. (C) 2016 Elsevier Ltd. All rights reserved.
Formation of porous layer with low Ni content on NiTi substrate by dealloying in metallic melts 査読有り

Kyosuke Ueda, Ryuma Hashimoto, Masahiro Hirohashi, Takeshi Wada, Hidemi Kato, Takayuki Narushima

Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy　63　(8)　766-770　2016年7月1日
出版者・発行元：Journal of the Japan Society of Powder and Powder Metallurgy
DOI： 10.2497/jjspm.63.766 　

ISSN：0532-8799

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NiTi has been used in biomedical implants because of its shape memory effect and superelasticity. In this study, a dealloying process was applied to NiTi substrates to form porous surfaces with low Ni content. The NiTi substrates were immersed in Ce or Mg melts for dealloying Ni. The reaction layers were characterized by using SEM/EDX and XRD. Upon dealloying, a porous layer consisting of NiTi2 and α-Ti phases was obtained at the surface of the NiTi. The Ni content in the porous layer formed at the surface of the NiTi substrate decreased step-wise until it reached a value of 2.0 at%. The thickness of the porous layer obtained by using the Ce melt was higher than that obtained by using the Mg melt, which might be due to the high affinity of Ni with Ce. 1 mass% lactic acid solution was used as an eluent for eluting Ni ions from the reaction layers. Although the amount of Ni ions eluted from the reaction layer formed by using the Ce melt was higher than that eluted from the as-polished NiTi substrate, the amount of eluting Ni ions per unit area decreased. In the case of the reaction layer obtained by using the Mg melt, the amount of eluting Ni ions was comparable with that from the as-polished NiTi substrate.
Microstructural evolution and mechanical properties of Co–Cr–Mo alloy subjected to high-pressure torsion 査読有り

M. Isik, M. Niinomi, K. Cho, M. Nakai, H. Liu, H. Yilmazer, Z. Horita, T. Narushima

J. Mech. Behav. Biomed. Mater.　59　226-235　2016年6月
出版者・発行元：None
DOI： 10.1016/j.jmbbm.2015.11.015 　

ISSN：1751-6161

eISSN：1878-0180
Fabrication of low-cost beta-type Ti-Mn alloys for biomedical applications by metal injection molding process and their mechanical properties 査読有り

Pedro Fernandes Santos, Mitsuo Niinomi, Huihong Liu, Ken Cho, Masaaki Nakai, Yoshinori Itoh, Takayuki Narushima, Masahiko Ikeda

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS　59　497-507　2016年6月
出版者・発行元：ELSEVIER SCIENCE BV
DOI： 10.1016/j.jmbbm.2016.02.035 　

ISSN：1751-6161

eISSN：1878-0180

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Titanium and its alloys are suitable for biomedical applications owing to their good mechanical properties and biocompatibility. Beta-type Ti-Mn alloys (8-17 mass% Mn) were fabricated by metal injection molding (MIM) as a potential low cost material for use in biomedical applications. The microstructures and mechanical properties of the alloys were evaluated. For up to 13 mass% Mn, the tensile strength (1162-938 MPa) and hardness (308-294 HV) of the MIM fabricated alloys are comparable to those of Ti-Mn alloys fabricated by cold crucible levitation melting. Ti-9Mn exhibits the best balance of ultimate tensile strength (1046 MPa) and elongation (4.7%) among the tested alloys, and has a Young's modulus of 89 GPa. The observed low elongation of the alloys is attributed to the combined effects of high oxygen content, with the presence of interconnected pores and titanium carbides, the formation of which is due to carbon pickup during the debinding process. The elongation and tensile strength of the alloys decrease with increasing Mn content. The Ti-Mn alloys show good compressive properties, with Ti-17Mn showing a compressive 0.2% proof stress of 1034 MPa, and a compressive strain of 50%. (C) 2016 Elsevier Ltd. All rights reserved.
The antihistamine olopatadine regulates T cell activation in palladium allergy 査読有り

Naohiko Iguchi, Yuri Takeda, Naoki Sato, Kenichirou Ukichi, Akira Katakura, Kyosuke Ueda, Takayuki Narushima, Shigehito Higuchi, Kouetsu Ogasawara

INTERNATIONAL IMMUNOPHARMACOLOGY　35　(35)　70-76　2016年6月
出版者・発行元：ELSEVIER SCIENCE BV
DOI： 10.1016/j.intimp.2016.03.021 　

ISSN：1567-5769

eISSN：1878-1705

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Because of its corrosion resistance palladium (Pd) has been widely used in many consumer products ranging from fashion accessories to dental materials. Recently, however, an increase in Pd allergy cases has been reported. Metal allergy is categorized as a Type IV allergy, which is characterized as a delayed-type hypersensitivity reaction in which T cells are known to play an important role; however, the precise mechanism of their action remains unclear. Here we defined the relationship between histamine and the Pd allergic reaction specifically with respect to T cell responses. To verify the effects of histamine on T cells, we examined whether there is a change in IFN-gamma production following stimulation of histamine or the antihistamine, olopatadine hydrochloride (OLP), in vitro. In addition, we assessed whether OLP administration affected the degree of footpad swelling or IFN-gamma production during the Pd allergy response in mice. We found that histamine stimulation increased IFN-gamma production in T cells, specifically enhancing IFN-gamma production in CD8(+) T cells compared with CD4(+) T cells. Interestingly, OLP suppressed the production of IFN-gamma in CD8(+) T cells, and this compound inhibited footpad swelling and IFN-gamma production in mice with Pd allergy. These results suggest that histamine promotes the Type IV allergic reaction and thus, the histamine 1 receptor (H1R) might be useful therapeutic target for treatment of metal allergy. (C) 2016 Elsevier B.V. All rights reserved.
Microstructure and Mechanical Properties of Heat-Treated Co-20Cr-15W-10Ni Alloy for Biomedical Application 査読有り

Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　47A　(6)　2773-2782　2016年6月
出版者・発行元：SPRINGER
DOI： 10.1007/s11661-016-3488-5 　

ISSN：1073-5623

eISSN：1543-1940

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The microstructure and mechanical properties of a heat-treated biomedical ASTM F90 Co-20Cr-15W-10Ni (mass pct) alloy were investigated. The alloy was heat-treated at temperatures of 673 K to 1623 K (400 A degrees C to 1450 A degrees C) for holding times of 0.6 to 259.2 ks. The formation of M23X6-type (M: metallic element and X: C and N) and eta-phase (M6X-M12X type) precipitates was detected in the heat-treated alloys using a combination of electrolytic extraction and X-ray diffraction. The formation of precipitates deteriorated the ductility of the heat-treated alloys. On the other hand, both the tensile strength and elongation were improved by heat treatment at low temperatures of 673 K to 873 K (400 A degrees C to 600 A degrees C). In this heat-treated alloy, the density of stacking faults was higher than that of the as-received alloy, and the formation of the epsilon-phase was detected. (C) The Minerals, Metals & Materials Society and ASM International 2016
Formation and evaluation of thermally-oxidized titania layers on commercially pure Ti 査読有り

T. Narushima, N. Umetsu, T. Ueda, S. Sado, K. Ueda

Proceedings of Ti-2015: The 13th World Conference on Titanium　1717-1721　2016年5月6日

DOI： 10.1002/9781119296126.ch288 　
Preparation of Antibacterial ZnO-CaO-P2O5-Nb2O5 Invert Glasses 査読有り

Sungho Lee, Hirotaka Uehara, Anthony L, B. Maçon, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

Materials Transactions　30　30-34　2016年4月
Improvement in mechanical strength of low-cost β-Type Ti-Mn alloys fabricated by metal injection molding through cold rolling 査読有り

K. Cho, M. Niinomi, M. Nakai, P.F. Santos, H. Yilmazer, Y. Itoh, M. Ikeda, M. Abdel-Hady Gepreel, T. Narushima

J. Alloys Compd.　664　272-283　2016年4月
出版者・発行元：None
DOI： 10.1016/j.jallcom.2015.12.200 　

ISSN：0925-8388

eISSN：1873-4669
Structures and dissolution behaviors of MgO–CaO–P2O5–Nb2O5 glasses 査読有り

H. Maeda, S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga

Journal of Non-Crystalline Solids　438　18-25　2016年4月
出版者・発行元：None
DOI： 10.1016/j.jnoncrysol.2016.02.006 　

ISSN：0022-3093

eISSN：1873-4812
Structure and physicochemical properties of CaO–P2O5–Nb2O5–Na2O glasses 査読有り

H. Maeda, S. Lee, T. Miyajima, A. Obata, K. Ueda, T. Narushima, T. Kasuga

Journal of Non-Crystalline Solids　432　60-64　2016年1月
出版者・発行元：None
DOI： 10.1016/j.jnoncrysol.2015.06.003 　

ISSN：0022-3093

eISSN：1873-4812
α+β型Ti-(0～10)mass%V-(0.5～1)mass%O合金の組織と機械的特性査読有り

上田恭介, 小林達矢, 成島尚之

日本金属学会誌　80　(1)　60-65　2016年
出版者・発行元：None
DOI： 10.2320/jinstmet.JB201503 　

ISSN：0021-4876

eISSN：1880-6880
Grain refinement mechanism and evolution of dislocation structure of Co–Cr–Mo alloy subjected to high-pressure torsion 査読有り

M. Isik, M. Niinomi, H. Liu, K. Cho, M. Nakai, Z. Horita, S. Sato, T. Narushima, H. Yilmazer, M. Nagasako

Mater. Trans.　57　(7)　1109-1118　2016年
出版者・発行元：None
DOI： 10.2320/matertrans.M2016052 　

ISSN：1345-9678

eISSN：1347-5320
Optimization of microstructure and mechanical properties of Co–Cr–Mo alloys subjected to high-pressure torsion using a subsequent short-time annealing 査読有り

M. Isik, M. Niinomi, H. Liu, K. Cho, M. Nakai, Z. Horita, T. Narushima, K. Ueda

Mater. Trans.　57　(11)　1887-1896　2016年
出版者・発行元：None
DOI： 10.2320/matertrans.M2016112 　

ISSN：1345-9678

eISSN：1347-5320
Changes in Microstructure of Biomedical Co-Cr-Mo Alloys during Aging at 973 to 1373 K 査読有り

Kosuke Ueki, Yuto Kurihara, Shingo Mineta, Alfirano, Kyosuke Ueda, Shigenobu Namba, Takashi Yoneda, Takayuki Narushima

MATERIALS TRANSACTIONS　57　(12)　2048-2053　2016年
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MI201507 　

ISSN：1345-9678

eISSN：1347-5320

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Changes in the microstructure and hardness of biomedical Co-Cr-Mo forged alloys (Co-27Cr-6Mo-0.77Si-0.64Mn-0.17N-0.06C (mass%)) during aging were investigated with a focus on precipitation. After solution treatment at 1523 K for 1.8 ks, the alloys were subjected to aging at temperatures between 973 and 1373 K for up to 86.4 ks. eta-phase (M6X-M12X type), M23X6-type and pi-phase (A(2)T(3)X type) precipitates were detected after aging. The formation of pi-phase precipitates was detected in alloys aged between 1023 and 1123 K for holding times >= 21.6 ks, with a nose temperature between 1073 and 1123 K. The presence of Tr-phase precipitates in the aged Co-Cr-Mo alloy is reported for the first time; N contained within the alloy is believed to contribute to formation of the yr-phase. The formation of a hexagonal-close-packed Co-based metallic phase (epsilon-phase) was observed between 1023 and 1123 K. The Vickers hardness increased in alloys aged at 1023 and 1073 K. This increase in hardness is attributed to the presence Of pi-phase and epsilon-phase and their wide-area precipitation.
Effects of Precipitates and Albumin in Simulated Body Fluids on Pin-on-Disk Wear Behavior of Biomedical Co-Cr-Mo Alloys 査読有り

Kyosuke Ueda, Motoka Kasamatsu, Masanori Tanno, Kosuke Ueki, Jean Geringer, Takayuki Narushima

MATERIALS TRANSACTIONS　57　(12)　2054-2059　2016年
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MI201518 　

ISSN：1345-9678

eISSN：1347-5320

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Pin-on-disk wear tests using Co-Cr-Mo (CCM) alloy pins and disks were conducted in 0.14 NI NaCl solutions with and without albumin. To clarify the effect of precipitates in the CCM alloys on the alloy wear behavior, as-received (having precipitates) and solution-treated (having no precipitates) CCM alloys were used as specimens. Friction coefficients during wear testing were measured. After the wear testing, the mass loss of pins and disks, wear tracks on the disks, and the wear debris were examined using scanning electron microscopy (SEM) and laser microscopy (LM). The concentration of metallic ions in solution was analyzed by inductively coupled plasma-atomic emission spectroscopy (ICPAES). In the solution without albumin, the friction coefficient increased with increasing sliding time and discontinuous wear grooves with attached and detached sections were observed, indicating that adhesive wear was dominant. On the other hand, in the solution with albumin, the friction coefficient was constant independent of the sliding distance and continuous wear grooves were observed, indicating that abrasive wear was dominant. High amounts of mass loss were detected from the as-received alloys in the albumin solution, and it is theorized that the wear debris (including precipitates) enhanced the third-body wear. The concentration of Cr ions in solution was lower than the expected values based on the alloy composition. In the solution with albumin, it was thought that the Cr ions bonded with the albumin, increasing the amount of available Cr ions in solution.
Preparation of Antibacterial ZnO-CaO-P2O5-Nb2O5 Invert Glasses 査読有り

Sungho Lee, Hirotaka Uehara, Anthony L. B. Macon, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

MATERIALS TRANSACTIONS　57　(12)　2072-2076　2016年
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MI201503 　

ISSN：1345-9678

eISSN：1347-5320

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ZnO-CaO-P2O5-Nb2O5 invert glasses, with ZnO substituted for CaO, were successfully prepared using a melt-quenching method. Their structures, dissolution behaviors, and antibacterial abilities were evaluated. Niobate switched its role of network former to modifier with increasing ZnO content, as Zn2+ ions preferentially coordinated with phosphate groups. In parallel, with increasing content of ZnO in the glasses, P-O-Zn bonds were formed, which crosslinked phosphate groups with ZnO acting as a network former. As a result, the glass-forming ability and chemical durability of the glasses were improved. The glasses showed antibacterial ability to gram-positive and-negative bacteria.
Effect of light elements on fatigue properties of NiTi wires for designing biomedical stents 査読有り

K. Hara, K. Ueda, T. Narushima, F. Yamashita, K. Ishikawa

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　20-28　2015年12月18日
Microstructure, tensile properties and corrosive properties of ASTM F90 Co-20Cr-15W-10Ni Alloys 査読有り

K. Ueki, K. Ueda, T. Narushima

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　50-58　2015年12月18日
In vitro evaluation of Ag-containing calcium phosphates 査読有り

O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　95-103　2015年12月18日
Design, microstructural characterization and mechanical evaluation of novel Ti-Mn-Mo alloys for biomedical applications 査読有り

P.F. Santos, M. Niinomi, H. Liu, M. Nakai, K. Cho, T. Narushima

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　120-125　2015年12月18日
Behavior of oxygen in arc-melted Ti–Si alloys 査読有り

M. Watanabe, K. Ueda, T. Narushima, D. Matsuwaka

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　513-520　2015年12月18日
Microstructure and balanced mechanical properties of short-time solution treated Co-Cr-Mo alloys processed through high-pressure torsion 査読有り

M. Isik, M. Niinomi, H. Liu, M. Nakai, K. Cho, Z. Horita, T. Narushima

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　680-685　2015年12月18日
Formation of TiO2 layers on commercially pure Ti and Ti-Mo and Ti-Nb alloys by two-step thermal oxidation and their photocatalytic activity 査読有り

Shota Sado, Takatoshi Ueda, Kyosuke Ueda, Takayuki Narushima

APPLIED SURFACE SCIENCE　357　2198-2205　2015年12月
出版者・発行元：ELSEVIER SCIENCE BV
DOI： 10.1016/j.apsusc.2015.09.211 　

ISSN：0169-4332

eISSN：1873-5584

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Anatase-containing TiO2 layers were formed on commercially pure (CP) Ti and Ti-25mass%Mo (Ti-25Mo) and Ti-25mass%Nb (Ti-25Nb) alloys by two-step thermal oxidation. The first-step treatment was conducted in an Ar-1%CO atmosphere at 1073K for 3.6 ks, and the second-step treatment was conducted in air at 673-1073 K for 10.8 ks. The second-step temperature range for anatase formation was wider in the Ti alloys than in CP Ti. Photo-induced superhydrophilicity under UV irradiation was observed for the TiO2 layers with anatase fractions >= 0.6 on CP Ti and the Ti-25Mo alloy, and with anatase fractions >= 0.18 on the Ti-25Nb alloy. The TiO2 layers on the Ti-25Nb alloy exhibited excellent photocatalytic activity in the low anatase fraction region, which is considered to be caused by the incorporation of 1-3 at% Nb into the TiO2 layers. The rate constant of methylene blue degradation showed maxima at anatase fractions of 0.6-0.9. (C) 2015 Elsevier B.V. All rights reserved.
Visible light activities of TiO2 layers formed on Ti-Ag and Ti-Au alloys by thermal oxidation 査読有り

T. Ueda, S. Sado, K. Ueda, T. Narushima

Proceedings for International Symposium on Eco Topia Science 2015　2015年11月
Structures and dissolution behaviors of CaO-P2O5-TiO2/Nb2O5 (Ca/P ≥ 1) invert glasses 査読有り

S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga

J. Non-Cryst. Solids　426　35-42　2015年10月
出版者・発行元：None
DOI： 10.1016/j.jnoncrysol.2015.06.024 　

ISSN：0022-3093

eISSN：1873-4812
Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications 査読有り

Pedro Fernandes Santos, Mitsuo Niinomi, Ken Cho, Masaaki Nakai, Huihong Liu, Naofumi Ohtsu, Mitsuhiro Hirano, Masahiko Ikeda, Takayuki Narushima

ACTA BIOMATERIALIA　26　366-376　2015年10月
出版者・発行元：ELSEVIER SCI LTD
DOI： 10.1016/j.actbio.2015.08.015 　

ISSN：1742-7061

eISSN：1878-7568

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The microstructures, mechanical properties and biocompatibility of low cost beta-type Ti-(6-18)Mn alloys were investigated after solution treatment. Ti-9Mn exhibits the best combination of tensile strength and elongation among the fabricated alloys, and its performance is comparable to or superior to those of Ti-6Al-4V ELI (Ti-64 ELI) in terms of every parameter evaluated. A hardness of 338 HV, a Young's modulus of 94 GPa, a 0.2% proof stress of 1023 MPa, an ultimate tensile strength of 1048 MPa and elongation of 19% were obtained for Ti-9Mn. Furthermore, the cell viability and metallic ion release ratios are comparable to those of commercially pure titanium, making this alloy promising for biomedical applications. The Young's modulus is also lower than that of Ti-64 ELI (110 GPa), which can possibly reduce the stress shielding effect in implanted patients. Statement of significance This study evaluates mechanical and biological performance of low cost solution treated beta-type Ti-(6, 9, 13 and 18 mass%)Mn alloys. It includes alloys containing a Mn content range higher than most previously published works (which is around or lower than 8 mass%). Furthermore, the effects of the omega phase and the beta phase stability of the alloys over some mechanical properties and microstructures are discussed. Ion release behavior under simulated body fluids and cell viability are also evaluated. For the case of the Ti-9Mn, a mechanical and biological performance that is comparable to or superior than that of the widely used Ti-6Al-4V ELI and commercially pure Ti was observed. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Structure and dissolution behavior of MgO–P2O5–TiO2/Nb2O5 (Mg/P ≥ 1) invert glasses 査読有り

S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga

J. Ceram. Soc. Jpn.　123　(1442)　942-948　2015年10月
出版者・発行元：None
DOI： 10.2109/jcersj2.123.942 　

ISSN：1882-0743

eISSN：1348-6535
Formation of the χ-phase precipitate in Co-Cr-Mo alloys with additional Si and C 査読有り

K. Sugawara, Alfirano, S. Mineta, K. Ueda, T. Narushima

Metall. Mater. Trans. A　46A　(9)　4342-4350　2015年9月
出版者・発行元：None
DOI： 10.1007/s11661-015-3008-z 　

ISSN：1073-5623

eISSN：1543-1940
Synthesis and characterization of Ag-containing calcium phosphates with various Ca/P ratios 査読有り

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima, Celaletdin Ergun

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　53　111-119　2015年8月
出版者・発行元：ELSEVIER SCIENCE BV
DOI： 10.1016/j.msec.2015.04.025 　

ISSN：0928-4931

eISSN：1873-0191

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Ag-containing calcium phosphate (CaP) powders were synthesized by a precipitation method using aqueous solutions of calcium nitrate, silver nitrate, and ammonium phosphate. The powders were sintered at temperatures ranging from 1173 to 14731<. The charged atomic ratios of (Ca + Ag)/P and Ag/(Ca + Ag) in solution were varied from 133 to 1.67 and from 0 to 030, respectively. The Ag content in the as-precipitated CaP powders increased with the charged Ag/(Ca + Ag) atomic ratio in solution and was lower than the charged Ag/(Ca + Ag) value. The as-precipitated CaP powders consisted of hydroxyapatite (HA) as the main phase. Ag nanoparticles were observed on the as-precipitated HA particles under all conditions of Ag addition. After the sintering, HA,beta-TCP (tricalcium phosphate), alpha-TCP, and beta-CPP (calcium pyrophosphate) were mainly detected as CaPs on the basis of the Ca/P atomic ratio of the as-precipitated powders. The addition of Ag stabilized the beta-TCP phase, and the distribution of Ag in beta-TCP was homogeneous. A metallic Ag phase coexisted with HA. The solubility of Ag in HA was estimated to be 0.0019-0.0061 (Ag/(Ca + Ag)) atomic ratio, which was lower than that in beta-TCP (higher than 0.0536) and higher than that of beta-CPP (below the detection limit of analyses). (C) 2015 Elsevier B.V. All rights reserved.
Control of bioresorbability of amorphous calcium phosphate coating film with niobium added 査読有り

K. Ueda, T. Takahashi, A. Obata, T. Kasuga, T. Goto, T. Narushima

Proceedings of the Biomaterials International Conference 2015　1026　2015年6月
Effect of heat treatment of the microstructure and mechanical properties of biomedical Co-20Cr-15W-10Ni alloy 査読有り

K. Ueki, K. Ueda, T. Narushima

Proceedings of the Biomaterials International Conference 2015　1182　2015年6月
Evaluation of photocatalytic activity of the tio2 layer formed on ti by thermal oxidation 査読有り

Takayuki Narushima, Shota Sado, Natsumi Kondo, Kyosuke Ueda

Interface Oral Health Science 2014: Innovative Research on Biosis-Abiosis Intelligent Interface　65-78　2015年1月1日
出版者・発行元：Springer Japan
DOI： 10.1007/978-4-431-55192-8_6 　

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Two-step thermal oxidation was proposed for Ti and Ti alloys as a surface-treatment process for preparing an anatase-containing TiO2 layer. This process consisted of treatment in a CO-containing atmosphere (first step) and subsequent treatment in air (second step). In this chapter, first, the current status of TiO2 coating onto Ti and Ti alloys for biomedical applications is reviewed then our recent work on the phase and microstructure of TiO2 layers prepared on commercially pure (CP) Ti, Ti-25mass%Mo alloy, and Ti-25mass%Nb alloy by two-step thermal oxidation is described. The anatase fraction in the TiO2 layer was controlled through process parameters such as the second-step temperature. Finally, photocatalytic activity of TiO2 layers formed on the Ti and Ti alloys is evaluated, including: results of water contact angle, decomposition of methylene blue, and antibacterial effects.
CONTROL OF Ag RELEASE FROM Ag-CONTAINING CALCIUM PHOSPHATES IN SIMULATED BODY FLUID 査読有り

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima

BIOMATERIALS SCIENCE: PROCESSING, PROPERTIES, AND APPLICATIONS V　254　13-20　2015年
出版者・発行元：JOHN WILEY & SONS INC
DOI： 10.1002/9781119190134.ch2 　

ISSN：1042-1122

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The dissolution behavior of Ag-containing hydroxyapatite (HA) powders and their sintered compacts in a Tris buffer solution (TBS) with a pH value of 7.4 was investigated. The Ag-containing calcium phosphate powders were prepared by a precipitation method using aqueous solutions. The (Ca+Ag)/P and Ag/(Ca+Ag) atomic ratios in the solutions were set to 1.33 and 1.67 and 0 and 0.10, respectively. The precipitated powders were sintered at 1373 K for 1 d. beta-tricalcium phosphate (TCP) and HA were the main phases of the sintered compacts at (Ca+Ag)/P ratios of 1.33 and 1.67, respectively. Metallic Ag coexisted with HA, and Ag was incorporated into the beta-TCP matrix. Ag ion release was observed in both the as-precipitated powders and the sintered compacts in the TBS. The amount of Ag ion release from the sintered compacts of the beta-TCP matrix was higher than that from the sintered compacts with the HA matrix and metallic Ag particles. The formation of AgCl was confirmed during the immersion of both the as-precipitated powders and the sintered compacts.
Evaluation of Thin Amorphous Calcium Phosphate Coatings on Titanium Dental Implants Deposited Using Magnetron Sputtering 査読有り

Sou Yokota, Naruhiko Nishiwaki, Kyosuke Ueda, Takayuki Narushima, Hiroshi Kawamura, Tetsu Takahashi

IMPLANT DENTISTRY　23　(3)　343-350　2014年6月
出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS
DOI： 10.1097/ID.0000000000000098 　

ISSN：1056-6163

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Objective: Calcium phosphate is used for dental material because of its biocompatibility and osteoconductivity. Amorphous calcium phosphate (ACP) coatings deposited by magnetron sputtering can control their thickness and absorbability. This study aimed to evaluate and characterize ACP coatings deposited via magnetron sputtering. It was hypothesized that ACP coatings would enhance bone formation and be absorbed rapidly in vivo. Methods: ACP coatings that are 0.5 mu m in thickness were deposited via magnetron sputtering on dental implants. Uncoated implants served as controls. The effect of the ACP coatings in vivo was investigated in New Zealand white rabbit. To evaluate the effect of the ACP coatings on the bone response of the implants, the removal torque, implant stability quotient, and histomorphometric analysis were performed on the implants at 1, 2, and 4 weeks after implantation. Results: Results of the x-ray diffraction analyses confirmed the deposition of ACP coatings. Images from the scanning electron microscopy revealed that the coatings were dense, uniform, and 0.5 mu m in thickness and that they were absorbed completely. Mechanical stability and bone formation in the case of the ACP-coated implants were higher than those of control. Conclusion: These results suggest that implants coated with thin ACP layers improve implant fixation and accelerate bone response.
NKG2D+ IFN-γ+ CD8+ T cells are responsible for palladium allergy 査読有り

M. Kawano, M. Nakayama, Y. Aoshima, K. Nakamura, M. Ono, T. Nishiya, S. Nakamura, Y. Takeda, A. Dobashi, A. Takahashi, M. Endo, A. Ito, K. Ueda, N. Sato, S. Higuchi, T. Kondo, S. Hashimoto, M. Watanabe, M. Watanabe, T. Takahashi, K. Sasaki, M. Nakamura, T. Sasazuki, T. Narushima, R. Suzuki, K. Ogasawara

PLOS one　9　(2)　e86810　2014年2月
出版者・発行元：None
DOI： 10.1371/journal.pone.0086810 　

ISSN：1932-6203
Preparation of calcium pyrophosphate glass-ceramics containing Nb2O5 査読有り

Hirotaka Maeda, Tomohiro Miyajima, Sungho Lee, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　122　(1421)　122-124　2014年1月
出版者・発行元：CERAMIC SOC JAPAN-NIPPON SERAMIKKUSU KYOKAI
DOI： 10.2109/jcersj2.122.122 　

ISSN：1882-0743

eISSN：1348-6535

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New types of calcium phosphate glass-ceramics were prepared with the addition of Nb2O5 to the pyrophosphate region. The glass-ceramics contained alpha-Ca2P2O7, beta-Ca2P2O7, and orthorhombic Nb2O5. The concentrations of Ca, P and Nb elements released from the glass-ceramics were lower than those released from glass of the same chemical composition. Apatite formed on the surface of the glass-ceramics after soaking in 1.5 simulated body fluid for 7 days. The crystal phases of the glass-ceramics improved the chemical durability and apatite forming ability of the material. (C)2014 The Ceramic Society of Japan. All rights reserved.
Precipitate phases and mechanical properties of heat-treated ASTM F 90 Co-Cr-W-Ni alloy 査読有り

Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima

ADVANCED CERAMICS AND NOVEL PROCESSING　616　258-262　2014年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/KEM.616.258 　

ISSN：1013-9826

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The precipitation behavior during heat treatment and resulting mechanical properties of ASTM F 90 Co-20Cr-15W-10Ni (mass%) alloys were investigated with regards to their biomedical applications. Heat treatment was conducted at temperatures of 873 to 1623 K, for a holding time of 259.2 ks. The precipitates produced were then electrolytically extracted from the alloys and analyzed by X-ray diffraction (XRD). This revealed that the precipitates formed were an M23X6 type and/or eta-phase (i.e., an M6X-M12X type). The M23X6-type precipitate was detected across the entire heat-treatment temperature range; however, the.-phase precipitate was only detected at 1073 to 1473 K, becoming dominant at 1173 to 1373 K. The formation of M23X6 type precipitates at 873 K is shown to improve the mechanical properties of this alloy, whereas the domination by the eta-phase precipitate at higher temperatures causes deterioration in the ductility.
Microstructural analysis of biomedical Co–Cr–Mo alloy subjected to high-pressure torsion processing 査読有り

M. Isik, M. Niinomi, K. Cho, M. Nakai, J. Hieda, H. Yilmazer, Z. Horita, T. Narushima

Key. Eng. Mat.　616　263-269　2014年
出版者・発行元：None
DOI： 10.4028/www.scientific.net/KEM.616.263 　

ISSN：1013-9826
Photocatalytic evaluation of anatase layer formed on Ti alloys by thermal oxidation 査読有り

S. Sado, K. Ueda, T. Narushima, M. Kawano, K. Ogasawara

Proceedings for International Symposium on Eco Topia Science 2013　1131　2013年11月
Ag distribution in calcium phosphates with various Ca/P ratios 査読有り

O. Gokcekaya, K. Ueda, T. Narushima, C. Ergun

Proceedings for International Symposium on Eco Topia Science 2013　1113　2013年11月
Formation of Anatase on Commercially Pure Ti by Two-Step Thermal Oxidation Using N-2-CO Gas 査読有り

Nobuyuki Umetsu, Shota Sado, Kyosuke Ueda, Kazuki Tajima, Takayuki Narushima

MATERIALS TRANSACTIONS　54　(8)　1302-1307　2013年8月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.ME201315 　

ISSN：1345-9678

eISSN：1347-5320

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The phase of a TiO2 layer formed on commercially pure Ti by two-step thermal oxidation using N-2-CO gas was investigated. The oxidation process comprised two steps: treatment in an N-2-(0.1, 1 and 5)%CO atmosphere and treatment in air. A Ti(C,N,O) phase was formed after the first-step treatment conducted at 873-1123 K. In the second step, the oxidation of this phase at 573-773 K resulted in the formation of an anatase phase, while its oxidation at 873 K resulted in the formation of a single rutile phase. An increase in the CO partial pressure in the first step lowered the temperature for anatase phase formation. Further, in the second step, a single-phase anatase layer was formed at temperatures of 623 and 673 K.
Preparation of Ag-doped calcium phosphate 査読有り

O. Gokcekaya, K. Ueda, T. Narushima, C. Ergun

Proceedings of the 8th Pacific Rim International Congress on Advanced Materials and Processing　1679-1685　2013年8月
金属材料のセラミックスコーティング査読有り

成島尚之, 上田恭介

加工プロセスによる材料機能発現第176委員会第24回研究会資料　62-81　2013年
Phase and Formation/Dissolution of Precipitates in Biomedical Co-Cr-Mo Alloys with Nitrogen Addition 査読有り

Shingo Mineta, Alfirano, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　44A　(1)　494-503　2013年1月
出版者・発行元：SPRINGER
DOI： 10.1007/s11661-012-1399-7 　

ISSN：1073-5623

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The precipitates in as-cast and heat-treated biomedical Co-28Cr-6Mo-(0 to 0.35)C-(0.15 to 0.25) N alloys (mass pct) were investigated. Heat treatment was carried out at temperatures of 1473 K to 1573 K (1200 degrees C to 1300 degrees C) for holding periods of 0 to 43.2 ks. In the as-cast and heat-treated Co-Cr-Mo-N alloys, no precipitates were detected; nitrogen effectively inhibited the formation of the sigma-phase and stabilized the face-centered cubic (fcc) metallic gamma-phase. The precipitates observed in the as-cast and heat-treated Co-Cr-Mo-C-N alloys were of the M23X6 type, M2X type, pi-phase (M2T3X type with a beta-Mn structure), and eta-phase (M6X-M12X type). Complete precipitate dissolution was detected in the alloys with carbon contents of less than 0.3 mass pct regardless of the nitrogen content. The main precipitates were of the M2X and M23X6 types after heat treatment for 1.8 to 43.2 ks. The pi-phase precipitate was detected in the early stage of heat treatment at high temperatures. The formation of the M2X-type precipitate was enhanced by the addition of nitrogen, although the constitution of the precipitates depended on the balance between the nitrogen and carbon contents and the heat-treatment conditions. DOI: 10.1007/s11661-012-1399-7 (C) The Minerals, Metals & Materials Society and ASM International 2012
Effect of Ba deoxidation on oxygen content in NiTi alloys and non-metallic inclusions 査読有り

Daisuke Ito, Naruhiko Nishiwaki, Kyosuke Ueda, Takayuki Narushima

JOURNAL OF MATERIALS SCIENCE　48　(1)　359-366　2013年1月
出版者・発行元：SPRINGER
DOI： 10.1007/s10853-012-6753-z 　

ISSN：0022-2461

eISSN：1573-4803

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The effect of Ba deoxidation on the oxygen content and non-metallic inclusions in NiTi alloys was investigated. The NiTi alloy melt was held in a CaO crucible at 1673 K under Ar gas flow for 0-600 s. Metallic Ba (0.5-1.5 mass% with respect to NiTi alloy melt) was added to the melt. After melting, oxygen content of 710 and 330 mass ppm decreased to 210 and 130 mass ppm, respectively, after a holding time of 300 s after the addition of Ba. The oxygen in the melts was reduced to as low as 64 mass ppm after a second Ba deoxidation. The non-metallic inclusions observed in the NiTi alloys were the Ti4Ni2O (X) and Ti(C,N,O) (X) types. Decreased oxygen content through Ba deoxidation caused a change in the main phase of the non-metallic inclusions from the Ti4Ni2O (X) type to the Ti(C,N,O) (X) type, and a decrease in the area percents of the non-metallic inclusions.
β grain refinement of α+β type Ti-4.5Al-6Nb-2Fe-2Mo alloy using rare earth oxide precipitates 査読有り

K. Ueda, S. Nakaoka, T. Narushima

Mater. Trans.　54　(2)　161-168　2013年
出版者・発行元：None
DOI： 10.2320/matertrans.MC201207 　

ISSN：1345-9678

eISSN：1347-5320
Mass loss and ion elution of biomedical Co-Cr-Mo alloys during pin-on-disk wear tests 査読有り

Kyosuke Ueda, Kaori Nakaie, Shigenobu Namba, Takashi Yoneda, Keita Ishimizu, Takayuki Narushima

Materials Transactions　54　(8)　1281-1287　2013年

DOI： 10.2320/matertrans.ME201316 　

ISSN：1345-9678

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Pin-on-disk wear tests using biomedical Co-Cr-Mo alloy pins and alumina disks were conducted in Kokubo and 1% lactic acid solutions. The mass loss and elution of metallic ions were measured and the surface of the pin was observed after the wear test. Mass loss of the alloy pins in 1% lactic acid solution was 10 times higher than the mass loss in Kokubo solution. In Kokubo solution, the as-cast pins exhibited higher mass loss and higher total amount of eluted ions than solution-treated pins. The Cr and Mn ion content in Kokubo solution was lower than expected, based on the chemical composition of the alloy. The incorporation of Cr and Mn ions into the calcium phosphate detected on the wear track of disks is the possible reason for the small amount of these ions in Kokubo solution. © 2013 The Japan Institute of Metals and Materials.
RFマグネトロンスパッタリング法による非晶質リン酸カルシウムコーティングの評価

横田聡, 栗原淳, 西脇成彦, 玉手総一郎, 上田恭介, 成島尚之, 川村仁, 高橋哲

Japanese Journal of Maxillo Facial Implants　11　(3)　243-243　2012年11月
出版者・発行元：(公社)日本顎顔面インプラント学会
ISSN：1347-894X
Effects of Niobium Ions Released from Calcium Phosphate Invert Glasses Containing Nb2O5 on Osteoblast-Like Cell Functions 査読有り

Akiko Obata, Yoshiaki Takahashi, Tomohiro Miyajima, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

ACS APPLIED MATERIALS & INTERFACES　4　(10)　5684-5690　2012年10月
出版者・発行元：AMER CHEMICAL SOC
DOI： 10.1021/am301614a 　

ISSN：1944-8244

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The effects of niobium ions released from 60CaO-30P(2)O(5)-(10-x)Na2O-xNb(2)O(5) (mol %, x = 0-10) glasses on MC3T3-E1 cell functions were evaluated by culture tests with two systems; cell culture on glass plates, or in culture media containing glass extracts. Alkaline phosphatase (ALP) activity in the cells cultured on the glass plates containing 3 and 5 mol 96 of Nb2O5 was significantly higher than that on the Nb2O5-free glass, although proliferation was not enhanced on all glasses containing Nb2O5. Cells cultured in the medium containing 3 X 10(-7) M niobium ions showed the highest ALP activity in comparison with other Nb-containing media or normal medium, regardless of the presence of osteogenic factors (ascorbic acid, beta-glycerophosphate and dexamethasone) in the media. Calcium deposition by the cells cultured in the medium containing 3 x 10(-7) M niobium ions was twice as high as those cultured in medium containing no niobium ions. The effects of niobium ions were thought to depend on ion concentration, and to enhance differentiation and mineralization of osteogenic cells rather than their initial adhesion or proliferation.
Quantitative analyses of osteogenic-differentiation-related gene expressions in human osteoblast-like cells (Saos-2) cultured on hydroxyapatite and titanium 査読有り

M. Taira, W. Hatakeyama, H. Kihara, H. Kondo, K. Ueda, T. Narushima

J. Oral Tissue. Engin.　10　(1)　34-41　2012年10月1日
出版者・発行元：Japanese Association of Regenerative Dentistry
DOI： 10.11223/jarde.10.34 　

ISSN：1348-9623

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The purpose of this study was to examine osteogenic differentiation behaviors at gene expression levels of osteoblast-like cells (SaOS-2) when cultured on polystyrene (PS), hydoroxyapatite (HAP) and titanium (Ti) for 8, 16 and 24 days, using six primer sets such as those for genes (mRNAs) of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), alkaline phosphatase (ALPL), type 1 collagen (COL1A1), osteopontin (SPP1), bone Sialo protein (IBSP) and osteocalcin precursor (BGLAP). With respect to GAPDH control, ALPL and COL1A1; SPP1 and IBSP; and BGLAP were used as initial-stage, middle-to-late-stage, and last-stage osteogenic differentiation phenotype markers, respectively. Quantitative real-time RT-PCR analyses revealed that HAP most differentiated SaOS-2, followed by Ti while PS did least. It was re-confirmed that with respect to PS, HAP was an excellent osteo-conductive material while Ti also exerted moderate osteo-conductive effects on SaOS-2 in the cell culture condition.
Precipitates in biomedical Co-28Cr-6Mo-(0–0.41)C alloys heat-treated at 1473 K to 1623 K (1200 ℃ to 1350 ℃) 査読有り

S. Mineta, Alfirano, S. Namba, T. Yoneda, K. Ueda, T. Narushima

Metall. Mater. Trans. A　43A　(9)　3351-3358　2012年9月
出版者・発行元：None
DOI： 10.1007/s11661-012-1142-4 　

ISSN：1073-5623
Biomechanical Evaluation of Amorphous Calcium Phosphate Coated TNTZ Implants Prepared Using a Radiofrequency Magnetron Sputtering System 査読有り

Naru Shiraishi, Rong Tu, Risa Uzuka, Takahisa Anada, Takayuki Narushima, Takashi Goto, Mitsuo Niinomi, Keiichi Sasaki, Osamu Suzuki

MATERIALS TRANSACTIONS　53　(7)　1343-1348　2012年7月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.M2012078 　

ISSN：1345-9678

eISSN：1347-5320

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Ti-29Nb-13Ta-4.6Zr alloy (TNTZ), a new beta-type Ti alloy, has excellent advantages as a biomaterial, such as low Young's modulus and cytotoxicity, and the absence of allergens. However, it is unclear whether TNTZ can achieve sufficient osseointcgration for it to be used as a dental implant. The effectiveness of surface modification of TNTZ implants by radiofrequency (RF) magnetron sputtering is also unclear. We investigated the biomechanical behaviors of TNTZ implants in vivo, using cylindrical implants of four types: pure Ti, TNTZ, and pure Ti and TNTZ coated with amorphous calcium phosphate (ACP). The implants were inserted in rat femurs, and the femurs were subjected to biomechanical analyses after various time intervals. The results suggest that TNTZ implants can achieve osseointegration similar to that of pure Ti, and that surface modification with ACP by RF magnetron sputtering improves osseointegration, especially in the later stages of healing. doi:10.2320/matertrans.M2012078]
Precipitates in Biomedical Co-Cr-Mo-C-N-Si-Mn Alloys 査読有り

Alfirano, Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　43A　(6)　2125-2132　2012年6月
出版者・発行元：SPRINGER
DOI： 10.1007/s11661-011-1009-0 　

ISSN：1073-5623

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The microstructures of biomedical ASTM F 75/F 799 Co-28Cr-6Mo-0.25C-0.175N-(0 to 1)Si-(0 to 1)Mo alloys (mass pct) were investigated before and after heat treatment, with special attention paid to the effect of nitrogen on the phases and the dissolution of precipitates. The heat treatment temperatures and holding periods employed ranged from 1448 to 1548 K (1175 to 1275 A degrees C) and 0 to 43.2 ks, respectively. A blocky-dense pi-phase precipitate and a lamellar cellular colony, which consisted of an M2X type precipitate and a gamma phase, were mainly detected in the as-cast alloys with and without added Si, respectively. The addition of nitrogen caused cellular precipitation, while the addition of Si suppressed it and enhanced the formation of the pi phase. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analyses suggested that a discontinuous reaction, i.e., gamma (1) -> gamma (2) + M2X, might be a possible formation mechanism for the lamellar cellular colony. Nitrogen was enriched in the M2X type, eta-phase, and pi-phase precipitates, but was excluded from the M23X6 type precipitate. Complete precipitate dissolution was observed in all of the alloys under varied heat treatment conditions depending on the alloy composition. The addition of nitrogen decreased the time required for complete precipitate dissolution at low heat-treatment temperatures. At high temperatures, i.e., 1548 K (1275 A degrees C), complete precipitate dissolution was delayed by the partial melting that accompanied the formation of the precipitates such as the pi phase resulting in the boundary between the complete and incomplete precipitate dissolution regions in having a C-curved shape.
π-phase and χ-phase: new precipitates in biomedical Co-Cr-Mo alloys 招待有り査読有り

T. Narushima, S. Mineta, Alfirano, K. Ueda

Interface Oral Health Science 2011　72-80　2012年4月

DOI： 10.1007/978-4-431-54070-0_102 　
Calcium phosphate-coated titanium alloy implants prepared by radiofrequency magnetron sputtering: A review 査読有り

Naru Shiraishi, Yuko Suzuki, Naoko Sato, Takahisa Anada, Takashi Goto, Rong Tu, Mitsuo Niinomi, Takayuki Narushima, Kyosuke Ueda, Risa Uzuka, Osamu Suzuki, Keiichi Sasaki

Interface Oral Health Science 2011　352-354　2012年1月1日
出版者・発行元：Springer Japan
DOI： 10.1007/978-4-431-54070-0_102 　

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This review summarized dental implant coated with calcium phosphate films, especially prepared by radiofrequency (RF) magnetron sputtering system. Calcium phosphate films on titanium alloys fabricated by RF magnetron sputtering system have very thin layer (within 500 nm), high bonding strength (over 60 MPa) and excellent biocompatibilities, even though its films created under the condition of room temperature. This method may be providing the effective interface between tissues and some other materials.
Accelerated bone formation around titanium dental implants with amorphous calcium phosphate coating in rabbits 査読有り

Sou Yokota, Jun Kurihara, Naruhiko Nishiwaki, Soichiro Tamate, Kyosuke Ueda, Takayuki Narushima, Hiroshi Kawamura

Interface Oral Health Science 2011　243-245　2012年1月1日
出版者・発行元：Springer Japan
DOI： 10.1007/978-4-431-54070-0_69 　

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The aim of this study was to investigate the bone response of titanium dental implant with amorphous calcium phosphate (ACP) coating film fabricated using RF magnetron sputtering in rabbit. Calcium phosphate coating using RF magnetron sputtering acquires high bonding strength and nanouniformity of films. Moreover, it is reported that ACP was resorbed rapidly in vitro. The ACP-coated and noncoated implants were placed into rabbits. After 1, 2 and 4 weeks of implantation, the implant stability was evaluated by resonance frequency analysis (RFA) and bone formation was also evaluated histomorphometrically. The ACP-coated implants showed higher stability in RFA and improved bone-implant contact ratio in 4 weeks. Titanium dental implant coated with ACP fabricated using RF magnetron sputtering accelerated bone formation compared with that of non coated implants.
Grain refinement in α+β-type Ti-4.5Al-6Nb-2Fe-2Mo alloys through precipitation of TiB or rare earth oxides 査読有り

Y. Kimura, N. Umetsu, N. Iwata, S. Nakaoka, K. Ueda, T. Narushima

Proceedings of the 12th World Conference on Titanium (Ti-2011)　2077-2080　2012年
出版者・発行元：None
Two-step Gas Treatment of Commercially Pure Titanium for Anatase Layer Formation 査読有り

Nobuyuki Umetsu, Takuro Okazumi, Kyosuke Ueda, Takayuki Narushima

TI-2011: PROCEEDINGS OF THE 12TH WORLD CONFERENCE ON TITANIUM, VOL III　2106-2110　2012年
出版者・発行元：SCIENCE PRESS BEIJING

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A two-step gas treatment of commercially pure titanium (CP Ti) was investigated with a focus on the formation of the anatase phase. The first step was carried out in Ar-1%C0 atmosphere at 1073 K for 0 ks or in N-2 atmosphere at 1123 K for 14.4 ks. The subsequent second step was carried out in air at 473-873 K for 0 ks and 86.4 ks. A titanium oxycarbide (TiC1-xOx) layer was formed after the first-step treatment in Ar-1% CO atmosphere, and an anatase-rich TiO2 layer was obtained after the second-step treatments in air at 673-873 K for 0 ks and at 573-773 K for 86.4 ks. In particular, single-phase anatase formed under the condition of the second step in air at 573 K for 86.4 ks. The anatase fraction in reaction layer could be controlled by varying the temperature and holding time of the second step. Both the TiN and Ti2N phases were detected as reaction products after the first step in N-2 atmosphere, and an anatase-containing TiO2 layer was obtained after the second-step treatment in air at 723 K for 86.4 ks. The formation of TiN and its oxidation at low temperatures seem to be required for the preparation of an anatase-containing TiO2 layer on Ti.
Deoxidation of NiTi Alloys Using Metallic Barium and their Microstructures 査読有り

Takayuki Narushima, Daisuke Ito, Kyosuke Ueda

TI-2011: PROCEEDINGS OF THE 12TH WORLD CONFERENCE ON TITANIUM, VOL III　2050-2053　2012年
出版者・発行元：SCIENCE PRESS BEIJING

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The Ba deoxidation of NiTi alloy melts with two different levels of initial oxygen content was investigated. Metallic Ba was added to the NiTi alloy melts held in CaO crucibles at 1673 K. The oxygen and Ba contents in the melts were quantitatively measured, and the precipitates in the NiTi alloys were analyzed, based on electrolytic extraction, after cooling in the CaO crucibles. The oxygen contents of the NiTi alloy melts decreased to 131 ppm and to 212 ppm in the NiTi alloy melts with low and high levels of initial oxygen contents, respectively, through the Ba deoxidation. The Ba content in the NiTi alloy melts was less than 10 ppm,120 s after the addition of Ba, independent of the initial oxygen content levels. The content of the precipitates was decreased by the Ba deoxidation. The phase of the precipitates depended on the oxygen and carbon contents in the NiTi alloy melts; the Ba deoxidation changed the phase of the precipitates from Ni2Ti4O and Ti(C, N, O) types to Ti(C, N, O) and from Ni2Ti4O type to Ti(C,N, O) type for NiTi alloys with low and high levels of initial oxygen contents, respectively.
Precipitates in As-Cast and Heat-Treated ASTM F75 Co-Cr-Mo-C Alloys Containing Si and/or Mn 査読有り

Alfirano, Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　42A　(7)　1941-1949　2011年7月
出版者・発行元：SPRINGER
DOI： 10.1007/s11661-011-0604-4 　

ISSN：1073-5623

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The effect of the addition of Si or Mn to ASTM F75 Co-28Cr-6Mo-0.25C alloys on precipitate formation as well as dissolution during solution treatment was investigated. Three alloys-Co-28Cr-6Mo-0.25C-1Si (1Si), Co-28Cr-6Mo-0.25C-1Mn (1Mn), and Co-28Cr-6Mo-0.25C-1Si-1Mn (1Si1Mn)-were heat treated from 1448 K to 1548 K (1175 A degrees C to 1275 A degrees C) for a holding time of up to 43.2 ks. In the case of the as-cast 1Si and 1Si1Mn alloys, the precipitates were M(23)C(6)-type carbide, eta phase (M(6)C-M(12)C-type carbide), and pi phase (M(2)T(3)X-type carbide with a beta-Mn structure), while in the case of the as-cast 1Mn alloy, M(23)C(6)-type carbide and eta phase were detected. The 1Si and 1Si1Mn alloys required longer heat-treatment times for complete precipitate dissolution than did the 1Mn alloys. During the solution treatment, blocky dense M(23)C(6)-type carbide was observed in all the alloys over the temperature range of 1448 K to 1498 K (1175 A degrees C to 1225 A degrees C). At the heat-treatment temperature of 1523 K (1250 A degrees C), starlike precipitates with stripe patterns-comprising M(23)C(6)-type carbide and metallic face-centered-cubic (fcc) gamma phase-were detected in the 1Si and 1Si1Mn alloys. A pi phase was observed in the 1Si and 1Si1Mn alloys heat treated at 1523 K and 1548 K (1250 A degrees C and 1275 A degrees C) and in the 1Mn alloy heat treated at 1548 K (1275 A degrees C); its morphology was starlike-dense. The addition of Si appeared to promote the formation of the pi phase in Co-28Cr-6Mo-0.25C alloys at 1523 K and 1548 K (1250 A degrees C and 1275 A degrees C). Thus, the addition of Si and Mn affects the phase and morphology of the carbide precipitates in biomedical Co-Cr-Mo alloys.
Anatase formation on titanium by two-step thermal oxidation 査読有り

Takuro Okazumi, Kyosuke Ueda, Kazuki Tajima, Nobuyuki Umetsu, Takayuki Narushima

JOURNAL OF MATERIALS SCIENCE　46　(9)　2998-3005　2011年5月
出版者・発行元：SPRINGER
DOI： 10.1007/s10853-010-5177-x 　

ISSN：0022-2461

eISSN：1573-4803

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Two-step thermal oxidation of commercially pure Ti was investigated with a focus on the formation of anatase. A first-step treatment was conducted in Ar-(0.1-20)%CO atmosphere at a temperature of 773-1173 K for a holding time of 0 or 86.4 ks, and a subsequent second-step treatment was conducted in air at 473-873 K for 0-86.4 ks. Titanium oxides and titanium oxycarbide were obtained in the first step, with relative amounts depending on heating temperature, holding time, and CO partial pressure. An anatase-rich layer on Ti was obtained after second-step treatment in air at 573-773 K in cases where single-phase titanium oxycarbide formed in the first step. Thus, the formation of single-phase titanium oxycarbide in the first step and temperature control in the second step were required for the formation of an anatase-rich layer. The bonding strength of an anatase-rich layer with a thickness of 0.5 mu m was calculated to be around 90 MPa. This study reveals the conditions under which an anatase-rich layer with excellent adherence to Ti can be prepared by thermal oxidation.
Enhancement of nickel elution by lipopolysaccharide-induced inflammation 査読有り

Rina Tanaka, Yoshiaki Goi, Kenji Ishihara, Kyosuke Ueda, Takayuki Narushima, Hiroshi Ohtsu, Masahiro Hiratsuka, Noriyasu Hirasawa

JOURNAL OF DERMATOLOGICAL SCIENCE　62　(1)　50-57　2011年4月
出版者・発行元：ELSEVIER IRELAND LTD
DOI： 10.1016/j.jdermsci.2010.12.006 　

ISSN：0923-1811

eISSN：1873-569X

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Background: Implantations of metallic biomedical devices into bodies are increasing. The elution of Ni ions from these devices can lead to metal allergies. However, the molecular mechanisms of the elution have not been fully examined. Furthermore, it is not clear whether infection and inflammation affect the corrosion of metals. Objective: We examined whether the elution of Ni from metal wires and plates was enhanced by inflammation in vivo and in vitro. Methods: A Ni or SUS316L wire was implanted subcutaneously in the dorsum of mice. Lipopolysaccharide (LPS) was injected at the site immediately following the implantation. After 8, 24, and 72 h, the tissue around the wire was excised. RAW 264 cells were seeded on a Ni plate and incubated for 24 h in medium containing LPS. The amount of Ni in the tissue or conditioned medium was determined fluorometrically. Results: The release of Ni ions from the wire was significantly increased from 8 to 72 h, and further increased by LPS. LPS also enhanced the release of Ni ions by the cells, but only when they were attached to the Ni plate. Chloroquine, bafilomycin A(1) and amiloride markedly inhibited the effects of LPS. Conclusion: The activation of inflammatory cells on metals enhanced the elution of Ni probably via the release of protons at the interface of the cells and material. (C) 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
Assessment of the release of nickel from biomaterials in vivo and in vitro: enhancement by lipopolysaccharide 査読有り

Rina Tanaka, Yoshiaki Goi, Kenji Ishihara, Kyosuke Ueda, Takayuki Narushima, Hiroshi Ohtsu, K. Ohuchi, Masahiro Hiratsuka, Noriyasu Hirasawa

Inflam. Regene.　31　(3)　302-306　2011年
出版者・発行元：The Japanese Society of Inflammation and Regeneration
DOI： 10.2492/inflammregen.31.302 　

ISSN：1880-9693

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Biodevices are implanted for long periods of time, so the release of metal ions from alloys should be tested in tissues to assess the risk of inducing metal allergies. However there is little evidence that the release of metal ions from alloys in vivo is similar to that in vitro. We implanted metal wires in mice and determined the concentration of metal ions in tissue to analyze the mechanisms responsible for metal allergies. The release of ions from the Ni wire was detected within 8 h and attained a plateau 72 h after the implantation. Furthermore, it was significantly increased by an injection of LPS. The results indicated that the release of Ni was apparently enhanced by inflammatory responses. We also established an in vitro assay system using the murine macrophage cell line RAW 264. The addition of LPS apparently increased the amount of Ni released into the medium, indicating the activation of the cells to have enhanced the elution of ions from the Ni plate. Our in vitro model using LPS-stimulated RAW264 cells might reflect the elution of Ni in inflamed tissue.
Alkali Hydrothermal Synthesis of Zeolite A Using Oxide By-products 査読有り

Taichi Murakami, Yoshiyuki Sugano, Tsunetoshi Kinami, Takayuki Narushima, Yasutaka Iguchi, Chiaki Ouchi

ISIJ INTERNATIONAL　51　(1)　158-165　2011年
出版者・発行元：IRON STEEL INST JAPAN KEIDANREN KAIKAN
DOI： 10.2355/isijinternational.51.158 　

ISSN：0915-1559

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The alkali hydrothermal synthesis of zeolite A using oxide by-products such as blast furnace (BF) slag and aluminum dross was investigated. Na-P1 (Na(6)Al(6)Si(6)O(32) center dot 12H(2)O) was synthesized directly in NaOH aqueous solution for 86.4 ks at 373 K using BF slag, Al(2)O(3), and SiO(2). On the other hand, zeolite A was successfully synthesized by a two-step method including an elution treatment of Al(2)O(3). Under optimal conditions, the formation ratio of zeolite A in various compounds contained in the product was 56 %. The utilization of dross residue squeezed out from the aluminum dross as a raw material to synthesis of zeolite A let this ratio increase to 60 %. The heat of water adsorption of the product synthesized by the two-step method using BF slag, SiO(2), and aluminum dross residue was measured, and it was 184 J/g, being higher than that of commercial zeolite A.
Recovery of Calcium from BF Slag and Synthesis of Zeolite A Using Its Residue 査読有り

Taichi Murakami, Yoshiyuki Sugano, Takayuki Narushima, Yasutaka Iguchi, Chiaki Ouchi

ISIJ INTERNATIONAL　51　(6)　901-905　2011年
出版者・発行元：IRON STEEL INST JAPAN KEIDANREN KAIKAN
DOI： 10.2355/isijinternational.51.901 　

ISSN：0915-1559

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The elution and recovery of Ca from blast furnace slag and the alkali hydrothermal synthesis of zeolite A using the residue from the elution treatment were investigated using a ball-milling-type reaction vessel. The superior elution was obtained by using citric and formic acid solutions from which Ca could be selectively eluted from the slag. Whereas hydrochloric acid solution and ion-exchanged water were ineffective for Ca elution. Ca ions eluted in the solution were recovered as calcium formate by evaporation of water. From the formic acid eluted slag residue after three elution treatment cycles of the slag for 7.2 ks, zeolite A was synthesized in 1 mol/L NaOH solution with a reaction time of 86.3 ks at 343 K, without the addition of any other materials.
Precipitates in Biomedical Co-Cr-Mo-C-Si-Mn Alloys 査読有り

T. Narushima, Alfirano, S. Mineta, S. Namba, T. Yoneda, K. Ueda

ADVANCED MATERIALS RESEARCH QIR 12　277　51-+　2011年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/AMR.277.51 　

ISSN：1022-6680

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The phase and dissolution behavior of precipitates in biomedical ASTM F75 Co-Cr-Mo-C-Si-Mn alloys were investigated. Alloys of five different compositions, Co-28Cr-6Mo-0.25C-1Si, Co-28Cr-6Mo-0.25C-1Mn, Co-28Cr-6Mo-0.25C-1Si-1Mn, Co-28Cr-6Mo-0.15C-1Si, and Co-28Cr-6Mo-0.35C-1Si, were heat-treated from 1448 to 1548 K. The precipitates observed in the as-cast and heat-treated alloys were carbides (M23C6 type, eta-phase, and pi-phase) and an intermetallic compound (pi-phase). The main precipitates observed after heat treatment at high temperatures such as 1548 K were pi-phase and M23C6 type carbide. At these high temperatures, two types of starlike precipitates-dense and stripe-patterned-were observed. The starlike-dense precipitate was the pi-phase, and the starlike precipitate with a stripe pattern was identified as the M23C6 type carbide and metallic fcc gamma-phase. In the alloys heat-treated at 1448 to 1498 K, blocky-dense M23C6 type carbide was primarily observed. chi-phase was detected in the Co-28Cr-6Mo-0.15C-1Si alloy under as-cast condition and after heat treatment at 1448-1523 K for a short holding time. The addition of Si seemed to increase the holding time for complete precipitate dissolution because of the effects of Si on the promotion of pi-phase formation at high temperatures and the increased carbon activity in the metallic matrix.
Surface modification of titanium by pack cementation treatment using calcium phosphate powders for biomedical applications 査読有り

Kyosuke Ueda, Hajime Suto, Takayuki Narushima

METALS AND MATERIALS INTERNATIONAL　16　(4)　569-572　2010年8月
出版者・発行元：KOREAN INST METALS MATERIALS
DOI： 10.1007/s12540-010-0808-y 　

ISSN：1598-9623

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The surface modification of commercially pure titanium by pack cementation treatment using hydroxyapatite (HAp) or tetracalcium phosphate (TTCP) powder was investigated for temperatures ranging from 773 K to 1073 K. An HAp phase was detected on the surface of the titanium substrates after pack cementation treatment at temperatures of 973 K and 1073 K. After treatment using HAp and TTCP powders, a reaction layer with small HAp particles and pores containing small HAp particles, respectively, was observed. Apatite crystallites with a network pattern formed on the pack-cementation-treated titanium substrates after the substrates were immersed in Kokubo solution for 43.2 ks; such rapid apatite formation suggests that pack cementation treatment improves the biocompatibility of titanium.
Carbide Formation and Dissolution in Biomedical Co-Cr-Mo Alloys with Different Carbon Contents during Solution Treatment 査読有り

Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　41A　(8)　2129-2138　2010年8月
出版者・発行元：SPRINGER
DOI： 10.1007/s11661-010-0227-1 　

ISSN：1073-5623

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The microstructures of as-cast and heat-treated biomedical Co-Cr-Mo (ASTM F75) alloys with four different carbon contents were investigated. The as-cast alloys were solution treated at 1473 to 1548 K for 0 to 43.2 ks. The precipitates in the matrix were electrolytically extracted from the as-cast and heat-treated alloys. An M(23)C(6) type carbide and an intermetallic sigma phase (Co(Cr,Mo)) were detected as precipitates in the as-cast Co-28Cr-6Mo-0.12C alloy; an M(23)C(6) type carbide, a sigma phase, an eta phase (M(6)C-M(12)C type carbide), and a pi phase (M(2)T(3)X type carbide with a beta-manganese structure) were detected in the as-cast Co-28Cr-6Mo-0.15C alloy; and an M(23)C(6) type carbide and an eta phase were detected in the as-cast Co-28Cr-6Mo-0.25C and Co-28Cr-6Mo-0.35C alloys. After solution treatment, complete precipitate dissolution occurred in all four alloys. Under incomplete precipitate dissolution conditions, the phase and shape of precipitates depended on the heat-treatment conditions and the carbon content in the alloys. The pi phase was detected in the alloys with carbon contents of 0.15, 0.25, and 0.35 mass pct after heat treatment at high temperature such as 1548 K for a short holding time of less than 1.8 ks. The presence of the pi phase in the Co-Cr-Mo alloys has been revealed in this study for the first time.
チタン上への多層リン酸カルシウムコーティング膜の作製とその評価査読有り

上田恭介, 川﨑雄城, 後藤孝, 栗原淳, 川村仁, 成島尚之

粉体および粉末冶金　57　(5)　314-320　2010年5月

DOI： 10.2497/jjspm.57.314 　

ISSN：0532-8799
S0201-1-2 熱酸化プロセスを利用したチタン上へのアナターゼ皮膜形成と骨適合性評価(骨再生と骨再建のためのバイオマテリアル(1),社会変革を技術で廻す機械工学)

成島尚之, 上田恭介, 岡住拓朗

年次大会講演論文集　2010　13-14　2010年
出版者・発行元：一般社団法人日本機械学会
DOI： 10.1299/jsmemecjo.2010.5.0_13 　

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The oxide phase on Ti, TiO_2, is known to affect their properties. Anatase has been suggested to have excellent bone forming ability as compared to rutile. The anatase layer formation on Ti and its alloys by thermal oxidation could be the low-cost and simple surface treatment for improving their bone compatibility. We developed the two-step thermal oxidation process for the anatase layer formation on CP Ti. At the first-step, CP Ti is heat-treated in an Ar-CO atmosphere. At the second-step, the specimens were oxidized in air, and anatase-rich layer was obtained in the case of that oxycarbide (TiC_xO_y) single phase was formed at the first-step. The immersion tests in simulated body fluid showed that the anatase-rich layer improved the bone compatibility of CP Ti. The bonding strength between the anatase-rich layer and CP Ti was higher than 90 MPa.
New-generation metallic biomaterials 査読有り

T. Narushima

Metals for Biomedical Devices　355-378　2010年
出版者・発行元：Elsevier Ltd
DOI： 10.1533/9781845699246.4.355 　

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In this chapter, the current status of metallic biomaterials and the research and development of new-generation metallic biomaterials are discussed. First, the traditional metallic biomaterials are reviewed. The alloy design and properties of the new metallic biomaterials and the new processing technologies used in fabricating porous metallic biomaterials and in grain refining are then discussed. This chapter focuses on the following metallic biomaterials: stainless steels, cobalt (Co)-chromium (Cr) alloys, titanium (Ti) and its alloys, magnesium (mg) alloys, and bulk metallic glasses. Finally, the future trends in new-generation metallic biomaterials are presented. © 2010 Woodhead Publishing Limited All rights reserved.
Preparation of functionally graded bio-ceramic film by MOCVD 査読有り

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

MULTISCALE, MULTIFUNCTIONAL AND FUNCTIONALLY GRADED MATERIALS　631-632　193-+　2010年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.631-632.193 　

ISSN：0255-5476

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Functionally graded Ca-Ti-O/Ca-P-O films were prepared by MOCVD. The phases, composition and morphology of Ca-Ti-O and Ca-P-O films changed depending on the molar ratio of each precursors, total pressure (P-tot) and substrate temperature (T-sub). CaTiO3 films in a single phase were obtained at T-sub = 973 and 1073 K. CaTiO3 films prepared at 873 K had a dense and smooth surface, whereas that prepared at T-sub = 1073 K had complicated rough surface with a cauliflower-like texture. The graded texture of CaTiO3 films from columnar to fine grains was advantageous to good adherence for metal substrates. alpha-TCP and HAp films in a single phase were obtained at T-sub = 973 and 1073 K. Both alpha-TCP and HAp films had a dense and smooth surface. The maximum deposition rate of Ca-Ti-O and Ca-P-O films were 44 and 20 mu m/h, respectively, and several 10 times grater than that of sputtering method. Apatite formation rate strongly depended on the surface morphology of film. Apatite formed after 3 days on the CaTiO3 film, 14 days on the alpha-TCP film and 6 hours on the HAp film in a Hanks' solution.
Calcium Phosphate Coating on Blast-treated Titanium Implants by RF Magnetron Sputtering 査読有り

K. Ueda, T. Narushima, T. Goto, T. Katsube, H. Nakagawa, H. Kawamura, M. Taira

MULTISCALE, MULTIFUNCTIONAL AND FUNCTIONALLY GRADED MATERIALS　631-632　211-+　2010年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.631-632.211 　

ISSN：0255-5476

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Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.
Changes in microstructure of biomedical Co-Cr-Mo-C alloys with solution treating and aging 査読有り

S. Mineta, S. Namba, T. Yoneda, K. Ueda, T. Narushima

THERMEC 2009 SUPPLEMENT　89-91　377-+　2010年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/AMR.89-91.377 　

ISSN：1022-6680

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Microstructural changes occurring in biomedical Co-Cr-Mo alloys with three carbon levels due to solution treatment and aging were investigated. Ingots of Co-Cr-Mo alloys with three different carbon levels were prepared by vacuum furnace melting; their chemical composition was Co-28Cr-6Mo-xC (x = 0.12, 0.25 and 0.35 mass%). Precipitates were electrolytically extracted from as-cast and heat-treated alloys. An M23C6 type carbide and a sigma phase were detected as precipitates in as-cast Co-28Cr-6Mo-0.12C alloy, and an M23C6 type carbide and an eta phase (M6C-M12C type carbide) were detected in as-cast Co-28Cr-6Mo-0.25C and Co-28Cr-6Mo-0.35C alloys. Only the M23C6 type carbide was detected during solution treatment. Complete precipitate dissolution occurred in all the three alloys after solution treatment. The holding time required for complete precipitate dissolution increased with increasing carbon content and decreasing solution treatment temperature. Complete precipitate dissolution occurred in the Co-Cr-Mo-C alloys solution treated at 1523 K for 43.2 ks; they were then subjected to aging from 873 to 1473 K for a heating time up to 44.1 ks after complete precipitate dissolution in solution treatment at 1523 K for 43.2 ks. The M23C6 type carbide with a grain size of 0.1-3 mu m was observed after aging. A time-temperature-precipitation diagram of the M23C6 type carbide formed in the Co-28Cr-6Mo-0.25C alloy was plotted.
Microscopic observations and inflammatory cytokine productions of human macrophage phagocytising submicron titanium particles 査読有り

Masayuki Taira, Tadayoshi Kagiya, Hidemitsu Harada, Minoru Sasaki, Shigenobu Kimura, Takayuki Narushima, Takashi Nezu, Yoshima Araki

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　21　(1)　267-275　2010年1月
出版者・発行元：SPRINGER
DOI： 10.1007/s10856-009-3834-x 　

ISSN：0957-4530

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This study was performed to microscopically observe and measure inflammatory cytokine production by human macrophages phagocytosing submicron titanium (Ti) particles. Observations with secondary electron microscopy (SEM), SEM/electron probe microanalysis (EPMA) and transmission electron microscopy (TEM) indicated that macrophages [phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells] at 24 h in culture actively phagocytosed and accumulated submicron Ti particles in intracellular phagosomes, in which refinement of Ti particles occurred. The macrophages were also cultured for 24 h in four media with and without submicron Ti particles and lipopolysaccharide (LPS; components of bacteria). Whilst neither stimulus reduced cell viability, submicron Ti particles and LPS activation independently and synergistically caused the macrophages to produce three inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) at high levels in the culture supernatants. The inflammatory and osteolysis conditions caused by macrophages phagocytosing submicron Ti particles would be worsened by challenge with LPS in patients wearing Ti prostheses.
Phase and Morphology of Carbides in ASTM F75 Co-Cr-Mo-C Alloys Formed at 1473 to 1623 K 査読有り

Shingo Mineta, Alfi Rano, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

PRICM 7, PTS 1-3　654-656　2176-+　2010年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.654-656.2176 　

ISSN：0255-5476

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The phase and morphology of precipitates in heat-treated Co-28Cr-6Mo-xC (x = 0.12, 0.15, 0.25, and 0.35mass%) alloys were investigated. The as-cast alloys were solution-treated in the temperature range of 1473 to 1623 K for 0 to 43.2 ks. Complete precipitate dissolution was observed in all four alloys, each of which had different carbon contents. The holding time for complete dissolution was greater for alloys with greater carbon content. The curve representing the boundary between the complete- and incomplete-dissolution conditions for each alloy is C shaped. Under the incomplete precipitate dissolution conditions of the Co-28Cr-6Mo-0.25C alloy, an M23C6 type carbide and a pi-phase (M2T3X type carbide with beta-Mn structure) were observed at 1548 to 1623 K, and starlike precipitates with a stripe pattern and with a dense appearance were both observed; the former comprised the M23C6 type carbide + gamma-phase, and the latter was the pi-phase. In contrast, only a blocky-dense M23C6 type carbide was observed at 1473 to 1523 K.
Heat Treatment of ASTM F75 Co-Cr-Mo-C-Si-Mn Alloys 査読有り

Alfirano, Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

PRICM 7, PTS 1-3　654-656　2180-+　2010年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.654-656.2180 　

ISSN：0255-5476

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In this study, the carbide dissolution and formation of biomedical Co-28Cr-6Mo-0.25C-1Si (1Si) and Co-28Cr-6Mo-0.25C-1Mn (1Mn) alloys occurring during solution treatment and aging were investigated. The addition of Si or Mn markedly affected the behavior of precipitates during heat treatment. The alloy with added Si required a longer solution treatment time for complete precipitate dissolution as compared to the alloy with added Mn. Blocky M23C6-type carbide was observed during solution treatment at 1448-1523 K. Starlike precipitates were observed in the I Si and 1Mn alloys at 1523-1548 K and 1523 K, respectively. The starlike precipitates exhibited two types of morphologies: dense and stripe patterned. The starlike precipitates with dense and stripe-patterned appearances were a pi-phase and M23C6-type carbide + metallic gamma-phase, respectively. An M23C6-type carbide and an eta-phase were formed during the aging of both the 1Si and the 1Mn alloys. In addition, an intermetallic sigma-phase was detected during the aging of the 1Si alloy at 1373 K.
Pack Cementation Treatment of Titanium Using Tetracalcium Phosphate Powder for Biomedical Applications 査読有り

Kyosuke Ueda, Hajime Suto, Kaori Nakaie, Takayuki Narushima

PRICM 7, PTS 1-3　654-656　2172-2175　2010年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.654-656.2172 　

ISSN：0255-5476

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The surface modification of commercially pure titanium (CP Ti) by pack cementation treatment at 973 K using tetracalcium phosphate (Ca(4)(PO(4))(2)O, TTCP) slurry was investigated. An HAp phase and a CaTiO(3) phase were observed on the reaction layer of the CP Ti substrate after pack cementation treatment at 973 K for 86.4 ks. TTCP powder decomposed to HAp and CaO, and CaO reacted with TiO(2) to form CaTiO(3). The reaction layer on the CP Ti substrate consisted of inner and outer layers and the particles were in the outer reaction layer. The pores observed on the reaction layer were formed by the detachment of particles from the outer layer. The bonding strength of the reaction layer was 68.1 MPa. Apatite completely covered the surface of the pack-cementation-treated CP Ti after immersion in Kokubo solution for 21.6 ks; such rapid apatite formation suggests that pack cementation treatment improves the biocompatibility of titanium.
Calcium Phosphate Coating on Titanium Using Dry Process 査読有り

Takayuki Narushima, Kyosuke Ueda, Takashi Goto, Jun Kurihara, Hiroshi Kawamura

PRICM 7, PTS 1-3　654-656　2162-+　2010年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.654-656.2162 　

ISSN：0255-5476

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Oxyapatite, amorphous calcium phosphate, and double-layered calcium phosphate coating films were fabricated on mirror-polished commercially pure titanium (CP Ti) and blasted Ti-6Al-4V alloy substrates by radiofrequency (RF) magnetron sputtering; the properties of these films were evaluated in vivo and in vitro. The bonding strength between the calcium phosphate films and the Ti substrates was higher than 50 MPa. This value is higher than the bonding strength reported in the case of plasma-sprayed calcium phosphate coating films fabricated on Ti substrates. The removal torque of screw-type blasted Ti-6Al-4V alloy implants in the femurs of Japanese white rabbits increased with the duration of implantation, and the removal torque values of the coated implants was observed to be higher than those of the non-coated implants. In vitro and in vivo studies indicate that coating Ti implants with calcium phosphate films using RF magnetron sputtering is effective in improving the bone compatibility of Ti implants. Finally, the factors that should be considered in fabricating biomedical coating films were discussed.
Effect of yttrium addition on grain growth of α, β and α+β titanium alloys 査読有り

B. Poorganji, A. Kazahari, T. Narushima, C. Ouchi, T. Furuhara

J. Phys.: Conf. Ser.　240　012170　2010年
出版者・発行元：None
DOI： 10.1088/1742-6596/240/1/012170 　

ISSN：1742-6588
Oxygen Distribution in Titanium Single Crystal Fabricated by Optical Floating-Zone Method under Extremely Low Oxygen Partial Pressure 査読有り

Koji Hagihara, Takahiro Tachibana, Keita Sasaki, Yoshiyuki Yoshida, Naoki Shirakawa, Tohru Nagasawa, Takayuki Narushima, Takayoshi Nakano

MATERIALS TRANSACTIONS　50　(12)　2709-2715　2009年12月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MA200903 　

ISSN：1345-9678

eISSN：1347-5320

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This study examines the properties of a titanium single crystal fabricated by the floating-zone-melting process in Ar gas flow atmosphere where the partial pressure of oxygen was maintained extremely low at P-O2 = similar to 10(-23) atm by the newly developed oxygen pump system. The distribution of solute oxygen atoms in the obtained single crystal exhibited a peculiar gradient. In the early stage of the titanium single crystal growth, the oxygen content in the single crystal (approximately 1600 ppm) was higher than that in the mother ingot (980 ppm). However, as the crystal growth progressed. the oxygen content gradually decreases and then reduced to 660 ppm in the final stage of crystal growth. Such a gradient of oxygen composition was not detected in titanium single crystals fabricated under conventional, commercial Ar gas flow atmosphere. owing to the unique gradient of oxygen content formed under extremely low oxygen partial pressure, the Vickers hardness of the single crystal decreased gradually along the crystal growth direction. [doi: 10.2320/matertrans.MA200903]
Surface Hardening Treatment for Titanium Materials Using Ar-5%CO Gas in Combination with Post Heat Treatment under Vacuum 査読有り

Y. Z. Kim, Takashi Konno, Taichi Murakami, Takayuki Narushima, Chiaki Ouchi

MATERIALS TRANSACTIONS　50　(12)　2763-2771　2009年12月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MA200911 　

ISSN：1345-9678

eISSN：1347-5320

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Surface hardening using solute oxygen formed by the dissociation of titanium oxide (TiO2) layer on commercially pure (C.P.) titanium, alpha + beta type Ti-4.5Al-3V-2Fe-2Mo (SP-700) alloy, and beta type Ti-15Mo-5Zr-3Al (Ti-15-53) alloy was investigated. This method consists of two steps: surface hardening using Ar-5%CO gas for a short time period and subsequent heat treatment under vacuum. Both treatments were carried out at 1073 K. The maximum Surface hardness and hardening layer depth for C.P. titanium obtained by surface hardening in Ar-5%CO gas for 1.8 ks were 420 Hv and 30 mu m, respectively. After post heat treatment for 14.4 ks, these values increased to 820 Hv and 70 mu m, respectively. The increase of surface hardening achieved by post heat treatment was yielded by solid solution hardening of oxygen via the following steps. Solute oxygen was continuously formed at the oxide layer/titanium interface by the dissociation of the oxide layer formed during surface hardening treatment. Oxygen then diffused into titanium matrix, which resulted in solid solution hardening. The highest and lowest values of the maximum surface hardness were obtained in C.P. titanium and Ti-15-53 alloy, respectively. On the other hand, the hardening layer depth was largest for Ti-15-53 alloy and smallest for C.P. titanium. These results can be explained by the differences in solubility and diffusivity of oxygen between the titanium a phase and phase. This two-step process appears to be a beneficial industrial surface hardening method for titanium materials because it enables the removal of the oxide layer while yielding surface hardness comparable to that obtained by the one-step process under the same total heat-treating time. [doi: 10.2320/matertrans.MA200911]
Behavior of Precipitates in Biomedical Co-Cr-Mo-C Alloys during Heat Treatment 査読有り

S. Mineta, Alfirano, S. Namba, T. Yoneda, K. Ueda, T. Narushima

Proceedings of Processing and Fabrication of Advance Materials　2009年12月
Effect of Addition of Alloying Elements on Microstructure of Biomedical Co-Cr-Mo Alloy 査読有り

Alfirano, S. Mineta, S. Namba, T. Yoneda, K. Ueda, T. Narushima

Proceedings of Processing and Fabrication of Advance Materials　2009年12月
Surface modification of titanium by dry process for biomedical applications 査読有り

T. Narushima, K. Ueda, T. Goto

Proceedings of the 9th International Symposium on Biomaterials　22-27　2009年10月29日
Precipitation Behavior in a Hanks’ Solution on Ca-P-O Films Prepared by Laser CVD 査読有り

M. Sato, R. Tu, T. Goto, K. Ueda, T. Narushima

Mater.Trans.　50　(10)　2455-2459　2009年10月
出版者・発行元：None
DOI： 10.2320/matertrans.M2009160 　

ISSN：1345-9678

eISSN：1347-5320
Fatigue behaviors of ultra fine wires of β-type and α-type titanium alloys 査読有り

S. Yonezawa, T. Narushima, K. Ueda, H. Kimura, Y. Iguchi

Mater. Trans.　50　(7)　1713-1719　2009年7月
出版者・発行元：None
DOI： 10.2320/matertrans.MF200920 　

ISSN：1345-9678

eISSN：1347-5320
Apatite formation behavior on bio-ceramic films prepared by MOCVD 査読有り

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　117　(1364)　461-465　2009年4月
出版者・発行元：CERAMIC SOC JAPAN-NIPPON SERAMIKKUSU KYOKAI
DOI： 10.2109/jcersj2.117.461 　

ISSN：1882-0743

eISSN：1348-6535

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Calcium titanate (CaTiO3), alpha-tricalcium phosphate (alpha-TCP) and hydroxyapatite (HAp) films were prepared by metal-organic chemical vapor deposition (MOCVD) using Ca(dpm)(2), Ti(O-i-Pr)(2)(dpm)(2) and (C6H5O3)PO precursors. The phases, composition and surface morphology of these films changed depending on substrate temperature (T-sub), total pressure (P-tot) and molar ratio of each precursors (R-Ca/Ti, R-Ca/P). The surface morphology of CaTiO3 films changed from granular structure to cauliflower-like texture, and its cross-sectional morphology changed from dense to columnar structure with increasing T-sub alpha-TCP and HAp films had granular surface and dense cross-sectional morphology. CaTiO3, alpha-TCP and HAp films were immersed in a Hanks' solution for 28 d. Apatite formation rate strongly depended on the surface morphology of CaTiO3 film, and apatite covered CaTiO3 film having a granular surface after 4 w while CaTiO3 film having a cauliflower-like texture after 3 d. Apatite covered alpha-TCP films after 14 d and HAp films after 6 h, respectively. HAp films prepared by MOCVD were promising as bone conductive materials. (C) 2009 The Ceramic society of Japan. All rights reserved.
Gene Expression Analyses of Human Macrophage Phagocytizing sub-μ Titanium Particles by Allergy DNA Chip (GenopalTM) 査読有り

M. Taira, T. Nezua, M. Sasaki, S. Kimura, T. Kagiya, H. Harada, T. Narushima, Y. Araki

Bio-Medical Materials and Engineering　19　(1)　63-70　2009年
出版者・発行元：None
DOI： 10.3233/BME-2009-0564 　

ISSN：0959-2989
Calcium phosphate films with/without heat treatments fabricated using RF magnetron sputtering 査読有り

Kyosuke Ueda, Yuuki Kawasaki, Takayuki Narushima, Takashi Goto, Jun Kurihara, Hironobu Nakagawa, Hiroshi Kawamura, Masayuki Taira

Journal of Biomechanical Science and Engineering　4　(3)　392-403　2009年

DOI： 10.1299/jbse.4.392 　

ISSN：1880-9863

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Calcium phosphate coating films were fabricated on blast-treated titanium plates and screw-type titanium implants using RF magnetron sputtering. A uniform and dense coating film with a thickness of 0.5 μm could cover the blast-treated titanium plate efficiently, maintaining the surface roughness of the substrates. The as-sputtered coating films consisted of amorphous calcium phosphate (ACP) or oxyapatite (Ca10(PO4)6O, OAp). Heat treatments of the OAp coating films were conducted in a silica ampoule or in air, and it was observed that the crystallinity of the coating films increased after the heat treatment. The bonding strength between the as-sputtered coating films, subjected to heat treatment in air, and the blast-treated titanium plates exceeded 60 MPa. An immersion test was conducted and alkaline phosphatase (ALP) activity of osteoblasts was investigated in vitro. The dissolution rate of the coating films in the 0.9% NaCl solution decreased with an increase in their crystallinity. The ACP coating film exhibited high ALP activity. As the in vivo evaluation, the coated and non-coated titanium implants were implanted into the femur of Japanese white rabbits. The percentage of bone-implant contact and the removal torque value of the coated titanium implants were greater than those of the non-coated titanium implants.
チタンのユビキタス化戦略査読有り

新家光雄, 塙隆夫, 池田勝彦, 千葉昌彦, 古原忠, 成島尚之, 土谷浩一, 江村聡, 中野貴由, 竹中俊英

2008年12月
極低酸素分圧雰囲気下でのTi単結晶の帯溶融育成査読有り

萩原幸司, 橘孝洋, 佐々木啓太, 吉田良行, 白川直樹, 長澤亨, 成島尚之, 中野貴由

日本金属学会誌　72　(12)　928-934　2008年12月
出版者・発行元：None
DOI： 10.2320/jinstmet.72.928 　

ISSN：0021-4876

eISSN：1880-6880
真空後熱処理を組み合わせたAr-5%COガスを利用したチタン材料の表面硬化処理法査読有り

金元哲, 今野昂, 村上太一, 成島尚之, 大内千秋

日本金属学会誌　72　(12)　1002-1009　2008年12月
出版者・発行元：None
DOI： 10.2320/jinstmet.72.1002 　

ISSN：0021-4876

eISSN：1880-6880
Hydroxyapatite formation on Ca-P-O coating prepared by MOCVD 査読有り

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

MATERIALS TRANSACTIONS　49　(8)　1848-1852　2008年8月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MRA2008097 　

ISSN：1345-9678

eISSN：1347-5320

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Ca-P-O coatings of alpha-tricalcium phosphate (alpha-TCP) and hydroxyapatite (HAp) films were prepared on commercially pure Ti (CP-Ti) by MOCVD using Ca(dpm)(2) and (C6H5O)(3)PO precursors. The behavior of apatite formation on the Ca-P-O coatings was investigated by immersing specimens in a Hanks' solution. An apatite phase has regenerated on the alpha-TCP coating after 1 day and has covered the whole specimen surface after 14d. On the HAp coating. an apatite phase has regenerated after 1 h and has covered the whole surface after 6h. The microstructure of the regenerated apatite phase on the HAp coating has changed from a needle-like to a network texture after 12h.
RFマグネトロンスパッタリング法を用いた吸収性薄層リン酸カルシウムコーテイングインプラントに関する実験的研究査読有り

中川浩伸, 勝部朝之, 上田恭介, 栗原淳, 後藤孝, 成島尚之, 川村仁

日本顎顔面インプラント学会誌　7　(1)　3-13　2008年6月25日
ブラスト処理を施したTi-6Al-4V合金基板へのリン酸カルシウムコーティングと生体内外評価査読有り

成島尚之, 上田恭介, 後藤孝, 勝部朝之, 川村, 仁, 中川, 浩伸平雅之

粉体および粉末冶金　55　(5)　318-324　2008年5月

DOI： 10.2497/jjspm.55.318 　

ISSN：0532-8799
MOCVD法によるCa-Ti-OおよびCa-P-O系傾斜機能バイオセラミックス膜の合成査読有り

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

粉体および粉末冶金　55　(5)　325-330　2008年5月

DOI： 10.2497/jjspm.55.325 　

ISSN：0532-8799
The effect of solute elements on hardness and grain size in platinum based binary alloys 査読有り

Taichi Murakami, Ryoji Sahara, Daisuke Harako, Masahiro Akiba, Takayuki Narushirna, Chiaki Ouchi

MATERIALS TRANSACTIONS　49　(3)　538-547　2008年3月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MRA2007265 　

ISSN：1345-9678

eISSN：1347-5320

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The effects of 25 kinds of solute elements on hardness and grain size in annealed Pt-based binary alloys were investigated together with cold workability and a hardness variation with a cold rolling reduction. Gain size largely varied depending on solute elements and their concentrations, and so the decrement in grain size per I at% solute addition was evaluated based on grain size difference between pure platinum and a respective alloy. This value markedly reduced in the low solute concentration range below 5 at%, followed by a sluggish reduction in the higher solute concentration range. Hardness values obtained in all alloys were corrected considering contribution of hardening due to grain refinement, and solid solution hardening was evaluated by the increment in hardness per I at% solute addition. The lattice constants of pure platinum and alloys were measured to calculate the size misfits. The increment in hardness increased with the increase in the size misfit in all alloys, and this relationship was clearly divided into two groups depending on whether the binary alloy system is a completely miscible type or a type with the solubility limit. The increment in hardness in the latter type of alloys was much higher than that of the former, and this value became larger with the increase in the inverse value of the solubility limit in Pt-based binary alloy. The superior cold workability and very similar work hardening behavior were observed in all Pt-based binary alloys.
Deoxidation of NiTi alloy melts using metallic barium 査読有り

Susumu Miyamoto, Masatoshi Watanabe, Takayuki Narushima, Yasutaka Iguchi

MATERIALS TRANSACTIONS　49　(2)　289-293　2008年2月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MRA2007219 　

ISSN：1345-9678

eISSN：1347-5320

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The deoxidation behavior of NiTi alloy melts with metallic barium was investigated. Metallic barium was added to the NiTi alloy melts held in lime (CaO) crucibles at 1673 K, and the concentrations of oxygen, barium and calcium in the melts were quantitatively measured. The oxygen content in a raw NiTi alloy bar was 660 ppm, and the oxygen content in the NiTi alloy melts just before barium addition was around 1100 ppm. Oxygen was introduced into the melts by the dissolution of lime during melting. The addition of barium lowered the oxygen content in the melts with the formation of deoxidation product, which might be barium oxide. The oxygen content was measured to be around 350 ppm 120 s after barium addition. The barium and calcium contents were less than 10 ppm and 12 ppm, respectively, indicating that the deoxidation product was removed from the melts in a very short period of time. These results suggest that barium is an effective deoxidation element for NiTi alloy melts. Furthermore, the interaction between oxygen and barium cannot be ignored in thermodynamic considerations of the deoxidation process.
Evaluation of sliding wear resistant property of CP titanium and SP-700 titanium alloy surface-hardened by Ar-5%CO gas 査読有り

Y. Z. Kim, Taichi Murakami, Takayuki Narushima, Chialki Ouch

ISIJ INTERNATIONAL　48　(1)　89-98　2008年
出版者・発行元：IRON STEEL INST JAPAN KEIDANREN KAIKAN
DOI： 10.2355/isijinternational.48.89 　

ISSN：0915-1559

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Sliding wear resistant properties of C.P. titanium and SP-700 alloy surface-hardened by Ar-5%CO gas were evaluated using a counterpart material of a bearing steel, JIS SUJ-2 steel and Nishihara type of sliding wear testing machine. In the latter, two disk specimens were rotated at different rotating speeds under a given compressive applied load, yielding a sliding ratio of 20 %. Wear tests were repeated intermittently for several times, and a respective test time period in each series of wear tests was primarily varied. The mass loss in both disks was measured after each test. Wear resistance of annealed C.P. titanium without surface hardening was inferior to that of annealed SUJ-2 steel, but surface hardened C.P. titanium resulted in superior wear resistance over quench-tempered SUJ-2 steel with a hardness of 720 in Hv. Observation results of worn surfaces in both disks indicate that preferential wear occurred in the convex region of a furrow-like pattern formed by a lathe machining, resulting in a reduction of surface roughness values with wear progress. When a respective test time period was extended to 21.6 ks, adhesive wear took place between worn surfaces in both specimens, and the mass loss ratio in titanium disk increased at a much higher rate compared with that of a respective test time period of less than 14.4 ks. The steel debris torn off from worn surface of SUJ-2 steel disk was observed to adhere to the worn surface in surface hardened C.P. titanium disk. Wear resistant property of surface hardened SP-700 alloy was also superior to quench-tempered SUJ-2 steel.
New Manufacturing Method of Iron Foam using Precursor Made of Iron, Graphite and Hematite Powders 査読有り

T. Murakami, K. Ohara, T. Narushima, C. Ouchi

POROUS METALS AND METALLIC FOAMS: METFOAM 2007　145-+　2008年
出版者・発行元：DESTECH PUBLICATIONS, INC

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Iron based metal foam has several advantages over aluminum alloy foam such as high strength, high energy absorbability and low cost. However, it is hard to manufacture iron foam using conventional foaming agents because of a significant difference between their decomposition temperatures and melting point of iron. In this study, a new manufacturing method of iron foam in use of CO and CO2 gases as foaming agents was studied, which was generated by reduction of iron oxide by carbon contained in iron melt. In this method, the cold-pressed precursor made of pure iron, graphite and hematite powders is heated at temperatures between solidus and liquidus in Fe-C binary system. The powder size and the amount of hematite used to make a precursor markedly affected the porosity and pore size of iron foam. Iron foam with the porosity of approximately 55% was obtained using the precursor with the composition of Fe-3.1%C-1.0%FezO(3).
Austenitic Grain Growth behavior Immediately after Dynamic Recrystallization in HSLA Steels and Austenitic Stainless Steel 査読有り

Noriki Fujita, Ryoji Sahara, Takayuki Narushima, Chiaki Ouchi

ISIJ INTERNATIONAL　48　(10)　1419-1428　2008年
出版者・発行元：IRON STEEL INST JAPAN KEIDANREN KAIKAN
DOI： 10.2355/isijinternational.48.1419 　

ISSN：0915-1559

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Austenitic grain growth behavior after dynamic recrystallization in HSLA steels and the austenitic stainless steel of Type 316L was investigated focusing on grain growth during a very short holding time period immediately after hot deformation. Hot compressed specimens were isothermally held at temperatures of 1373 K, 1 423 K and 1473 K for various time periods from 0.1 s to 1.8 ks. The grain size in all steels was coarsened by 1.5 to 2.5 times in a short holding time period of 20 s. Addition of 0.078%Zr or 0.018%Ti in HSLA steel could not prevent this rapid grain growth, which retarded grain growth in a longer holding time period over 60 s. The grain growth exponent of the n value was evaluated using a formulated grain growth kinetic equation, and two n values largely differing in the fine and coarse grain size regions were obtained in a respective temperature and alloy. The n value in the latter region ranged from 2.3 to 3.2, being almost consistent with values of various materials reported in the past studies. The very high n value over 77 was obtained in the fine grain size region for dynamic recrystallization in all steels, where n values for static recrystallization was relatively lower than those for dynamic recrystallization. The similar result of n values was obtained from grain growth data after dynamic recrystallization in pure nickel. The cause for very high n value and the difference of n values obtained from grain growth data after dynamic and static recrystallizations were discussed based on features of the microstructure and the grain boundary evolved by dynamic or static recrystallization and annealing.
Fatigue Properties of Titanium Wires for Medical Applications 査読有り

T.Narushima K.Ueda, T.Kinami, H.Kimura, C.Ouchi Y.Iguchi

Ti-2007, Science and Technology, Proc. the 11th World Conference on Titanium (JIMIC-5)　1505-1508　2007年12月20日
In vivo and in vitro Evaluations of Calcium Phosphate Films Coated on Titanium by RF Magnetron Sputtering 査読有り

K.Ueda T.Narushima T.Goto, H.Nakagawa, H.Kawamura, T.Katsube

Ti-2007, Science and Technology, Proc. the 11th World Conference on Titanium (JIMIC-5)　1477-1480　2007年12月20日
Effect of Alloying Elements on Hot Deformation of Duplex Titanium Alloys 査読有り

Behrang Poorganji Taichi, Murakami Takayuki, Narushima Chiaki Ouchi, Tadashi Furuhara

Ti-2007, Science and Technology, Proc. the 11th World Conference on Titanium (JIMIC-5)　535-538　2007年12月20日
Evaluation of amorphous calcium phosphate coating films fabricated on titanium by RF magnetron sputtering 査読有り

K. Ueda, T. Narushima, T. Goto, H. Nakagawa, H. Kawamura, T. Katsube

1st Asian Biomaterials Congress, Abstract　47　2007年12月
Development of a new method for manufacturing iron foam using gases generated by reduction of iron oxide 査読有り

Taichi Murakami, Kensuke Ohara, Takayuki Narushima, Chiaki Ouchi

MATERIALS TRANSACTIONS　48　(11)　2937-2944　2007年11月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MRA2007127 　

ISSN：1345-9678

eISSN：1347-5320

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A new method for manufacturing iron foam using CO and CO2 as foaming gases was studied. This method consists of three stages: (1) mixing powders of pure iron, graphite, and hematite; (2) preparing the precursor by cold pressing the mixed powders; and (3) foaming by heating the precursor at temperatures between the liquidus and solidus in the Fe-C binary system. Molten iron containing carbon is foamed by gases generated by a reduction reaction. Optimizations of both the composition of the precursor and the heating conditions are required to produce the iron foam with high porosity. It was found that the content and powder size of hematite in the precursor significantly affect the porosity and pore diameter of the iron foam. Iron foam with a porosity of 55% and average pore diameter of around 500 mu m is obtained by heating the precursor of Fe-3.1 mass%C-1.0 mass%Fe2O3 at 1543 K.
Dynamic and static restoration behaviors of pure lead and tin in the ambient temperature range 査読有り

Satoshi Hotta, Keigo Matsumoto, Taichi Murakami, Takayuki Narushima, Chiaki Ouchi

MATERIALS TRANSACTIONS　48　(10)　2665-2673　2007年10月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MRA2007078 　

ISSN：1345-9678

eISSN：1347-5320

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Dynamic and static restoration behaviors of pure lead and tin were investigated by compression tests, and the deformation temperature and strain rate were varied in the range from 223 to 348 K and from 2 x 10(-3) to 1 s(-1), respectively. Lead and tin used had two purity levels of 99.999% (5N) and 99.9% (3N), and 5N and 4N, respectively. The hot working simulator was reformed so as to enable compression tests at low temperatures ranged from 223 to 273 K. S-S curves observed in lead and tin were those in dynamic recrystallization and dynamic recovery types of metals, respectively, of which activation energies were 92 to 119 kJ/mol in lead and 49 to 52 kJ/mol in tin. Steady state flow stress in lead with 5N purity was lower than that of tin with 5N purity. A reduction of purity level from 5N to 3N in lead significantly increased flow stress, but difference in purity level of 5N and 4N in tin exerted tiny influence on flow stress at strain rate below 1 x 10(-1) s(-1). Static recrystallization in lead with 5N purity completed in the holding time of less than 600 s even at 273 K, while tin with the same purity showed a slightly retarded recrystallization progress. A reduction of purity level in both metals extended the time period for completion of recrystallization by more than 2 orders.
Fabrication of calcium phosphate films for coating on titanium substrates heated up to 773 K by RF magnetron sputtering and their evaluations 査読有り

Kyosuke Ueda, Takayuki Narushima, Takashi Goto, Masayuki Taira, Tomoyuki Katsube

Biomedical Materials　2　(3)　S160-S166　2007年9月1日

DOI： 10.1088/1748-6041/2/3/S14 　

ISSN：1748-6041 1748-605X

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Calcium phosphate films were fabricated on titanium substrates heated up to 773 K using radiofrequency (RF) magnetron sputtering. The deposition rate, phase and preferred orientation of the calcium phosphate films were studied. Immersion tests for the films were conducted using Hanks' solution and PBS(-), and the surface reactions on the specimens coated with the calcium phosphate films were investigated. The bonding strength between the coating films and the titanium substrates before and after the immersion tests was evaluated the bonding strength decreased after the immersion tests. The alkaline phosphatase (ALP) activity of SaOS-2 cells on a titanium plate coated with a calcium phosphate film was examined by conducting a culture test. Calcium phosphate coating increased the ALP activity of SaOS-2 cells cultured for 3 and 7 days. Titanium cylinders were coated with an amorphous calcium phosphate film and implanted into the mandibles of beagle dogs. An increase in the extent of bone-implant contact for the coated titanium cylinders was confirmed 8 to 12 weeks after implantation and compared with the case for uncoated titanium cylinders. © 2007 IOP Publishing Ltd.
Hydroxyapatite formation on CaTiO3 film prepared by metal-organic chemical vapor deposition 査読有り

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

MATERIALS TRANSACTIONS　48　(6)　1505-1510　2007年6月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MRA2007016 　

ISSN：1345-9678

eISSN：1347-5320

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Calcium titanate (CaTiO3) films were prepared on commercially pure titanium (CP-Ti) by metal-organic chemical vapor deposition using Ca(dpm)(2) and Ti(O-i-Pr)(2)(dpm)(2) precursors. The formation of hydroxyapatite (HAp, Ca-10(PO4)(6)(OH)(2)) on CaTiO3 film was investigated in a Hanks' solution. The formation rate of HAp was significantly affected by deposition conditions of CaTiO3 films, particularly substrate temperature (T-sub). The time for the HAp formation was 3.6 Ms (42 d) on the CaTiO3 film prepared at T-sub = 873 K, wheras that was 1.2 (14 d) and 0.3 Ms (3 d) on that prepared at T-sub = 973 and 1073 K, respectively. Octacalcium phosphate (OCP, Ca8H2(PO4)(6).5H(2)O) was identified oil the CaTiO3 film prepared at T-sub = 1073 K by the immersion for 21.6 ks.
The Effect of Small Amounts of Yttrium Addition on Grain Grwoth Under Superplastic Deformation Condition in Newly Developed α+β Type, Ti-4.5Al-6Nb-2Mo-2Fe Alloy 査読有り

B. Poorganji, S. Hotta, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

Advanced Materials Research　15-17　726-731　2007年4月
Evaluation of calcium phosphate coating films on titanium fabricated using RF magnetron sputtering 査読有り

Kyosuke Ueda, Takayuki Narushima, Takashi Goto, Tomoyuki Katsube, Hironobu Nakagawa, Hiroshi Kawamura, Masayuki Taira

MATERIALS TRANSACTIONS　48　(3)　307-312　2007年3月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.48.307 　

ISSN：1345-9678

eISSN：1347-5320

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Calcium phosphate coating films fabricated on commercially pure titanium (CP-Ti) substrates using radiofrequency (RF) magnetron sputtering were evaluated in vivo and in vitro for investigating their applications in dental and medical implants. For the in vitro evaluations of the calcium phosphate coating films, the bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a polished titanium plate exceeded 60 MPa. When compared with an uncoated titanium plate, the increase in the ALP activity of SaOS-2 cells (a well-characterized osteosarcoma human cell line exhibiting osteoblast-like properties) on a titanium plate coated with a calcium phosphate film was confirmed by a culture test. Titanium cylinders coated with an amorphous calcium phosphate film were implanted into the mandibles of beagle dogs. The percentage of bone-implant contact in coated titanium was greater than that in uncoated titanium.
Calcium phosphate films coated on titanium by RF magnetron sputtering for medical applications 査読有り

T. Narushima, K. Ueda, T. Goto, T. Katsube, H. Kawamura, C. Ouchi, Y. Iguchi

THERMEC 2006, PTS 1-5　539-543　551-+　2007年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.539-543.551 　

ISSN：0255-5476

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Calcium phosphate films were coated on commercially pure titanium substrates by radiofrequency magnetron sputtering using beta-tricalcium phosphate targets. The films consisted of amorphous calcium phosphate and oxyapatite phases. Immersion tests of the films were carried out in Hanks' solution and PBS(-), and apatite fort-nation and calcium ion elution from the films were investigated. The titanium cylinders coated with calcium phosphate films were implanted into the mandibles of beagle dogs. These results suggest that coating with calcium phosphate improves the biocompatibility of titanium implants with bone tissue.
EFFECTS OF COOLING RATE AND DIRECT HOT DEFORMATION CONDITIONS AFTER SOLIDIFICATION ON THE AUSTENITIC MICROSTRUCTURE EVOLVED BY SIMULATED STRIP CASTING AND THIN SLAB CASTING PROCESSES IN HSLA STEELS 査読有り

S. Hotta, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

THERMEC 2006 SUPPLEMENT　15-17　726-731　2007年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/AMR.15-17.726 　

ISSN：1022-6680

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Currently new continuous casting processes such as thin slab caster or strip casting are industrialized or under developing in the world steel makers. In these casting processes, cooling rate after solidification becomes much faster compared with thick slab caster, and hot rolling mill connected directly with casting machine tends to be installed. The present study was conducted to investigate variations of austenitic grain size and micro segregation with cooling rate after solidification and also direct hot deformation conditions in austenite immediately after solidification in HSLA steels. HSLA steels were 0.15%C-0.25%Si-1.50%Mn, 0.028%Nb and 0.028%Nb-0.015%Ti with the same basic compositions. A hot working simulator of THERMECMASTER-Z was used, and the center part of tensile specimen set up in this machine was partially or fully levitation-melted by induction heating under argon gas atmosphere. After melting, specimens were cooled at cooling rate from 0.4K/s to 40K/s, and this range covered cooling rates after solidification in heavy thick slab caster and strip casting. Direct hot tensile straining in austenite after solidification was conducted at strain rates from 1.4x10(-3) s(-1) to 2.6s(-1), corresponding to an extracting speed in a respective caster. The increase of cooling rate refined continuously as cast austenitic grain size, and it was enhanced in micro alloyed steels. Micro segregation such as Mn was improved by faster cooling. Direct straining after solidification markedly refined austenitic grain size through dynamic or static recrystallization occurring depending on strain rate.
The Effect of Small Amounts of Yttrium Addition on Static and under Superplastic Deformation Condition Grain Growth in Newly Developed α+β Type Ti-4.5Al-6Nb-2Mo-2Fe Alloy 査読有り

B.Poorganji, S.Hotta, T.Murakami, T.Narushima, Y.Iguchi, C.Ouchi

Advanced Materials Research　15-17　970-975　2007年
出版者・発行元：None
DOI： 10.4028/www.scientific.net/AMR.15-17.970 　

ISSN：1022-6680
Alloy Design and Properties of New α+β Titanium Alloy with Excellent Cold Workability, Superplasticity and Cytocompatibility 査読有り

T. Hirano, T. Murakami, M. Taira, T. Narushima, C. Ouchi

ISIJ International　47　(5)　745-752　2007年
出版者・発行元：None
DOI： 10.2355/isijinternational.47.745 　

ISSN：0915-1559
Variations in the Microstructure and Hardness with Solution Treating and Aging Conditions in New α+β Titanium Alloy Ti-4.5%Al-6%Nb-2%Fe-2%Mo 査読有り

T. Hirano, T. Murakami, T. Narushima, C. Ouchi

ISIJ International　47　(7)　1042-1049　2007年
出版者・発行元：None
DOI： 10.2355/isijinternational.47.1042 　

ISSN：0915-1559
In vitro evaluations of RF magnetron-sputtered calcium phosphate films on titanium 査読有り

Kyosuke Ueda, Takayuki Narushima, Tomoyuki Katsube, Hiroshi Kawamura, Takashi Goto

INNOVATION IN CERAMICS SCIENCE AND ENGINEERING　352　305-+　2007年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/0-87849-454-5.305 　

ISSN：1013-9826

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Calcium phosphate coating films were fabricated on mirror-polished or blast-treated titanium substrates using radio-frequency (RF) magnetron sputtering and they were evaluated in vitro. Immersion tests for the films were conducted using phosphate-buffered saline (PBS(-)), and apatite formation and the elution of calcium ions from the films were investigated. The bonding strengths between the calcium phosphate films and titanium substrates before and after the immersion tests were evaluated. After the immersion tests, a decrease in the bonding strength was observed for the coating films on the mirror-polished titanium substrates, while that for the blast-treated titanium substrates was almost the same as that before the immersion tests.
Hydroxyapatite formation on MOCVD-CaTiO3 coated Ti 査読有り

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

INNOVATION IN CERAMICS SCIENCE AND ENGINEERING　352　301-+　2007年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/0-87849-454-5.301 　

ISSN：1013-9826

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Ca-Ti-O films were prepared by MOCVD using Ca(dpm)(2) and Ti(OiPr)(2)(dpm)(2) precursors. The phases, composition and morphology of Ca-Ti-O films changed depending on the molar ratio of Ca to Ti precursors (R-Ca/Ti), total pressure (P-tot) and substrate temperature (T-sub). CaTiO3 films in a single phase were obtained at T-sub = 973 and 1073 K. CaTiO3 films prepared at 873 K had a dense structure and smooth surface. CaTiO3 films prepared at T-sub = 1073 K had complicated rough surface with a cauliflower-like texture. Hydroxyapatite (HAp) formed in 3 days on the CaTiO3 film prepared at T-sub = 1073 K.
Hydroxyapatite formation on calcium phosphate coated titanium 査読有り

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

PRICM 6: SIXTH PACIFIC RIM INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS AND PROCESSING, PTS 1-3　561-565　1513-+　2007年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.561-565.1513 　

ISSN：0255-5476

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Calcium phosphate films were prepared by MOCVD using Ca(dpm)(2) and (C6H5O)(3)PO precursors. The phases, composition and morphology of films changed depending on the molar ratio of Ca to P precursors (R-Ca/P), total pressure (P-tot) and substrate temperature (T-sub). alpha-tricalcimu phosphate (alpha-TCP, alpha-Ca-3(PO4)(2)) Films in a single phase were obtained at T-sub = 1073 K, 0.1 < R-Ca/P < 0.4 and T-sub = 973 K, RCa/P < 0.4. Hydroxyapatite (HAp, Ca-10(PO4)(6)(OH)(2)) films in a single phase were obtained at T-sub = 1073 K, 0.8 < R-Ca/P < 1.0 and T-sub = 973 K, 0.5 < R-Ca/P < 0.6. Ca-P-O films had a dense and smooth surface. HAp formed within 1 day on the alpha-TCP film and wholly covered the specimens within 2 weeks in a Hanks' solution. The surface of CVD-HAp film was covered by precipitated HAp within 6 hours.
口腔内自動骨延長器の開発：ビーグル犬下顎骨への適用査読有り

勝部朝之, 成島尚之, 中野貴由, 馬越佑吉, 佐々木具文, 伊藤秀美, 古屋泰文, 川村仁

第6回バイオメカニクス論文集　2006年12月
Accumulation of Element Ti in Macrophage-like RAW 264 cells Cultured in Medium with 1ppm Ti and Effect on cell viability, SOD production and TNF-α secretion 査読有り

M.Taira, K.Sasaki, S.Saitoh, T.Nezu, M.Sasaki, S.Kimura, K.Terasaki, K.Sera, T.Narushima, Y.Araki

Dent. Mater. J.　25　(4)　726-732　2006年12月
出版者・発行元：None
DOI： 10.4012/dmj.25.726 　

ISSN：0287-4547
In Vivo Evaluation of Calcium Phosophate Films on Titanium Implant by RF Magnetron Sputtering 査読有り

T.Katsube, H.Nakagawa, T.Narushima, H.Kawamura

Proceedings of XVIII International Congress of the European Association for Cranio-Maxillofacial Surgery　67-72　2006年12月
Oxidation or nitridation behavior of pure chromium and chromium alloys containing 10 mass% ni or Fe in atmospheric heating 査読有り

Kaori Taneichi, Takayuki Narushima, Yasutaka Iguchi, Chiaki Ouchi

MATERIALS TRANSACTIONS　47　(10)　2540-2546　2006年10月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.47.2540 　

ISSN：1345-9678

eISSN：1347-5320

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The oxidation or nitridation behavior of pure chromium and chromium alloys containing 10 mass%Ni or 10 mass%Fe in atmospheric heating was investigated in the temperature range of 1073 to 1373 K. The formation behavior of the outer oxide phase of Cr2O3 and its growth kinetics in both chromium alloys was very similar to that of pure chromium. The nitride layer with the Cr2N phase was formed beneath the oxide phase at temperatures above 1273 K in pure chromium. Marked internal nitridation with the formation of the Cr2N phase was observed in the Cr-10 mass%Fe alloy, while the formation Of Cr2N was negligible in the Cr-10 mass%Ni alloy. Neither Ni nor Fe were detected inside the Cr2O3 phase, and was enriched in the subsurface layer between the oxide layer and the base alloy in a respective alloy. The Ni-enriched layer in Cr-10mass%Ni alloy had a relatively narrow width, but a very high concentration of Ni compared with the Fe-enriched layer formed in the Cr-10mass%Fe alloy.
MOCVD法による傾斜組成生体適合性膜の作製査読有り

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

傾斜機能材料論文集　20　109-114　2006年10月
Surface hardening treatment in use of CO gas and post-heat treatment in C.P. titanium and titanium alloys 査読有り

Y. Z. Kim, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

Solid State Phenomena　118　109-114　2006年
出版者・発行元：Trans Tech Publications Ltd
DOI： 10.4028/www.scientific.net/SSP.118.109 　

ISSN：1662-9779

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Surface hardening treatment of titanium materials in use of CO gas was studied including investigation of post heat treatment under vacuum. C.P. titanium, α+β type SP-700 alloy with Ti-4.5%Al-3%V-2%Mo-2%Fe and β type alloy with Ti-15%Mo-5%Zr-3%Al were used. Surface hardening was conducted by heating these materials at 1073K for 21.6ks in Ar-5%CO gas. Subsequently, specimens subjected to surface hardening were heated at 1073k for various time periods under vacuum. While the maximum surface hardness value was the largest in C.P. titanium and the least in SP-700 alloy, hardening layer thickness was the thickest in β type alloy and the thinnest in C.P. titanium. Surface hardening in C.P. titanium was brought about by solid solution hardening due to oxygen and carbon. Enrichment of these elements in the surface layer of both titanium alloys caused continuous variations of the microstructure such as β to α+β, or their volume fractions in the surface hardening layer. Post heat treatment at 1073K increased the maximum surface hardness and hardening layer thickness with an extension of the heating time in C.P. titanium, but the surface maximum hardness decreased continuously in β type titanium alloy. Post heat treatment could remove the thin oxide layer formed by surface hardening treatment.
β Grain Refinement due to Small Amounts of Yttrium Addition in α+β Type Titanium Alloy, SP-700 査読有り

S. Hotta, K. Yamada, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

ISIJ International　46　(1)　129-137　2006年
出版者・発行元：None
DOI： 10.2355/isijinternational.46.129 　

ISSN：0915-1559
CO2ガスを利用したチタンおよびチタン合金の表面硬化処理査読有り

金元哲, 佐原亮二, 成島尚之, 井口泰孝, 大内千秋

鉄と鋼　92　(1)　1-9　2006年1月
出版者・発行元：None
DOI： 10.2355/tetsutohagane1955.92.1_1 　

ISSN：0021-1575
Alloy Design and Property Evaluation of New β type Titanium Alloy with Excellent Cold Workability and Biocompatibility 査読有り

K. Taneichi, M. Taira, E. Sukedai, T. Narushima, Y. Iguchi, C. Ouchi

ISIJ International　46　(2)　292-301　2006年
出版者・発行元：None
DOI： 10.2355/isijinternational.46.292 　

ISSN：0915-1559
Surface hardening treatment in use of CO gas and post-heat treatment in CP titanium and titanium alloys 査読有り

Y. Z. Kim, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

HEAT TREATMENT OF MATERIALS　118　109-+　2006年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/3-908451-25-6.109 　

ISSN：1012-0394

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Surface hardening treatment of titanium materials in use of CO gas was studied including investigation of post heat treatment under vacuum. C.P. titanium, alpha+beta type SP-700 alloy with Ti-4.5%A1-3%V-2%Mo-2%Fe and beta type alloy with Ti-15%Mo-5%Zr-3%Al were used. Surface hardening was conducted by heating these materials at 1073K for 21.6ks in Ar-5%CO gas. Subsequently, specimens subjected to surface hardening were heated at 1073k for various time periods under vacuum. While the maximum surface hardness value was the largest in C.P. titanium and the least in SP-700 alloy, hardening layer thickness was the thickest in beta type alloy and the thinnest in C.P. titanium. Surface hardening in C.P. titanium was brought about by solid solution hardening due to oxygen and carbon. Enrichment of these elements in the surface layer of both titanium alloys caused continuous variations of the microstructure such as beta to alpha+beta, or their volume fractions in the surface hardening layer. Post heat treatment at 1073K increased the maximum surface hardness and hardening layer thickness with an extension of the heating time in C.P. titanium, but the surface maximum hardness decreased continuously in beta type titanium alloy. Post heat treatment could remove the thin oxide layer formed by surface hardening treatment.
Characterization of calcium phosphate films prepared by RF magnetron sputtering 査読有り

Takayuki Narushima, Kyosuke Ueda, Takashi Goto, Tomoyuki Katsube, Hiroshi Kawamura, Chiaki Ouchi, Yasutaka Iguchi

MATERIAL AND DEVICES FOR SMART SYSTEMS II　888　101-+　2006年
出版者・発行元：MATERIALS RESEARCH SOC
ISSN：0272-9172

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Calcium phosphate films were prepared on commercially pure titanium (CP-Ti) substrates by RF magnetron sputtering using beta-tricalcium phosphate targets. XRD and FTIR analyses showed that the films consisted of amorphous calcium phosphate and oxyapatite phases. The (002) preferred orientation of the oxyapatite phase was observed depending on the oxygen gas concentration in the sputtering gas. The surface reactions of the calcium phosphate films were investigated in Hanks' solution and PBS(-). Apatite crystallites were detected on the films after immersion for 7 days. An active surface reaction was observed on the amorphous calcium phosphate films during immersion in PBS(-). The CP-Ti plates coated with the calcium phosphate films were placed on the mandible of male Japanese white rabbits. These results suggest that the calcium phosphate coating improves the biocompatibility of titanium implants with bone.
Surface hardening treatment for CP titanium and titanium alloys in use of Ar-5%CO gas 査読有り

Y. Z. Kim, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

ISIJ INTERNATIONAL　46　(9)　1329-1338　2006年
出版者・発行元：IRON STEEL INST JAPAN KEIDANREN KAIKAN
DOI： 10.2355/isijinternational.46.1329 　

ISSN：0915-1559

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Surface hardening of C.P. (commercially pure) titanium and titanium alloys in use of Ar-5%CO gas was investigated in the temperature range between 973 K and 1 123 K. Ttanium materials used were alpha+beta type alloy of Ti-4.5%Al-3%V-2%Mo-2%Fe (SP-700) and beta type alloy of Ti-15%V-3%Cr-3%Sn-3%Al (Ti-15-333). Oxidation accompanied with surface hardening in use of Ar-5%CO gas is much reduced compared with that of Ar-20%CO2 gas. Surface hardening was evaluated by both of the maximum surface hardness and hardening layer depth obtained from hardness distribution profiles in the subsurface region, The former is the highest in C.P. titanium and the lowest in Ti-15-333 alloy, and the latter is the deepest in Ti-15-333 alloy and the shallowest in C.P. titanium. Surface hardening in C.P. titanium is caused by solid solution hardening of oxygen and carbon enriched in the subsurface region. Enrichment of these interstitials in the subsurface region of SP-700 or Ti-15-333 alloys causes the increase of a volume fraction in alpha+beta two phases or phase transformation from beta to alpha+beta two phases, respectively, and surface hardening is primarily controlled by volume fraction of alpha phase hardened by interstitials enrichment. The other beta type titanium alloy of Ti-15%Mo-5%Zr-3%Al yields much marked surface hardening over T-15-333 alloy. All of these results were analyzed and discussed based on oxygen and carbon concentration profiles, which were obtained by EPMA, and were also calculated by uni-dimensional diffusion model.
Surface Hardening treatment in use of CO gas and Post-heat treatment in C.P. Titanium and Titanium Alloys 査読有り

Y. Z. Kim, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

Proceedings of The 3rd Asian Conference on Heat Treatment of Materials　252-254　2005年11月
Preferred Orientation of Calcium Phosphate Films Prepared by RF Magnetron Sputtering 査読有り

K. Ueda, T. Narushima, T. Goto, T. Katsube, H. Kawamura, C. Ouchi, Y. Iguchi

Archives of BioCeramics Research　5　59-62　2005年11月
Preparation of calcium phosphate films by radiofrequency magnetron sputtering 査読有り

T Narushima, K Ueda, T Goto, H Masumoto, T Katsube, H Kawamura, C Ouchi, Y Iguchi

MATERIALS TRANSACTIONS　46　(10)　2246-2252　2005年10月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.46.2246 　

ISSN：1345-9678

eISSN：1347-5320

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Calcium phosphate films were prepared on titanium substrates by radiofrequency (RF) magnetron sputtering at RF powers from 75 to 150 W. Hot-pressed beta-tricalcium phosphate (beta-TCP) plates with a high density (> 99.6%) were used as a sputtering target. The substrate was not intentionally heated. The films consisted of amorphous calcium phosphate and oxyapatite (Ca-10(PO4)(6)O) phases, The ratio of the oxyapatite phase depended on the sputtering conditions of RF power. oxygen gas concentration in the sputtering gas (Co-2) and total pressure in the chamber. The (002) preferred orientation of oxyapatite phase was observed. The deposition rate of films increased with increasing RF power and decreasing Co-2. The highest deposition rate was 0.143 nm center dot s(-1) (0.515 mu m center dot h(-1)).
Development of dental and medical systems for reconstruction of human body with high performance titanium materials 査読有り

Tomoyuki Katsube, Kyosuke Ueda, Takayuki Narushima, Takashi Goto, Yasutaka Iguchi, Hiroshi Kawamura

International Congress Series　1284　324-325　2005年9月

DOI： 10.1016/j.ics.2005.06.067 　

ISSN：0531-5131

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Calcium phosphate films on the surface of titanium have been investigated in order to apply them to the device for clinical treatments in oral and maxillofacial fields. The calcium phosphate films were coated on substrates by RF magnetron sputtering method. Commercially pure titanium (CP-Ti) plates were used as substrates. The films consisted of amorphous calcium phosphate and oxyapatite phases. The c-axis, (002), preferred orientation of oxyapatite phase was observed. The histological results demonstrated that the titanium plates coated with the calcium phosphate film were in close contact with bone at some parts of the interfaces between the bone and the implant, compared with non-coated titanium plates. © 2005 Elsevier B.V. All rights reserved.
Fatigue properties of stainless steel wire ropes for electrodes in functional electrical stimulation systems 査読有り

T Narushima, K Suzuki, T Murakami, C Ouchi, Y Iguchi

MATERIALS TRANSACTIONS　46　(9)　2083-2088　2005年9月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.46.2083 　

ISSN：1345-9678

eISSN：1347-5320

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The fatigue properties of stainless steel wire ropes with 19 strands developed for a functional electrical stimulation (FES) electrode in simulated body fluids were investigated. The wire ropes were made of a new austenite stainless steel (Fe-22Cr-10Ni-6Mn-2Mo-0.4N alloy) and Type 316L stainless steel. Fatigue properties of the wire ropes were evaluated in Hanks' solution and 1 mass% lactic acid solution at 310K using a dual axel-driven rotating-bending fatigue machine. After fatigue testing, the wire ropes were examined by scanning electron microscopy and the metal ion concentrations in the solutions were quantitatively determined. Corrosion products in the solutions were analyzed by transmission electron microscopy. Under low maximum cyclic bending stress level, the Fe-22Cr-10Ni-6Mn-2Mo-0.4N alloy wire rope exhibited a higher cyclic life than the Type 316L stainless steel wire rope. Metal ion concentrations in the lactic acid solution increased with increasing of number of fatigue cycles, and no corrosion products were detected. In Hanks' solution, ferric oxyhydroxides (FeOOH) were formed as corrosion products during fatigue testing and the concentrations of metal ions were lower than those in the lactic acid solution for cyclic tests over 104 cycles.
Materials Transactions: Preface

Mitsuo Niinomi, Takao Hanawa, Yoshimitsu Okazaki, Masahiko Ikeda, Akihiko Chiba, Takayuki Narushima, Hisao Fukui

Materials Transactions　46　(7)　1514　2005年7月

ISSN：1345-9678
The Effects of Dynamic Recrystallization on γ Grain Refinement and Improvement of Micro Segregation of As Cast Austenite in 9%Ni Steel 査読有り

S. Hotta, T. Murakami, T. Narushima, Y. Iguchi, C. Ouchi

ISIJ International　45　(3)　338-346　2005年
出版者・発行元：None
DOI： 10.2355/isijinternational.45.338 　

ISSN：0915-1559
Hydrothermal synthesis of zeolite a using blast furnace slag 査読有り

Y Sugano, R Sahara, T Murakami, T Narushima, Y Iguchi, C Ouchi

ISIJ INTERNATIONAL　45　(6)　937-945　2005年
出版者・発行元：IRON STEEL INST JAPAN KEIDANREN KAIKAN
DOI： 10.2355/isijinternational.45.937 　

ISSN：0915-1559

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Alkali hydrothermal synthesis of zeolite A using blast furnace (BF) slag was investigated. The preliminary experiment was conducted in use of synthetic slag consisting of SiO2, Al2O3, and CaO powders, and it was made clear that the most optimum slag compositions to synthesize zeolite A were the molar ratio of Si to Al (Si/Al) of I and reduction of CaO content down to 15 mass%, and that hydrothermal treating conditions were the temperature range from 328 to 358 K, NaOH solution of 1 M (=mol/L) and the ratio of the volume of NaOH solution to total mass of slag (V-sol/W-slag) of 15 (mL/g). It was also found that synthetic slag with such a higher content of CaO as 40% resulted in formation of tobermorite and hydrogarnet. In the experiment using BF slag, zeolite A could be successfully synthesized by optimizing both conditions of the compositions of raw material powders and hydrothermal treatment as noted above, where optimization of the compositions of raw material powders such as Si or Al content were performed by the suitable amount of addition Of SiO2 powder or NaAlO2 powder as a source of Si and Al. The ball milling type reaction vessel containing numerous small SiC balls which was first adopted in this hydrothermal treating study was confirmed to be very effective for acceleration of synthetic reaction rate, shortening markedly the time period needed for fully synthesis of zeolite A. Temperature dependence of heat capacity of zeolite A powder synthesized in use of BF slag was measured after absorption of vapor at the ambient temperature, showing endothermic behavior with the peak at the temperature of around 473 K.
Wear loss and elution of CPTi and titanium alloys in simulated body fluids 査読有り

K Ueda, T Narushima, C Ouchi, Y Iguchi

PRICM 5: THE FIFTH PACIFIC RIM INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS AND PROCESSING, PTS 1-5　475-479　2333-2336　2005年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.475-479.2333 　

ISSN：0255-5476

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Wear behavior of titanium materials such as C.P.Ti, Ti-6Al-4V and Ti-6Al-7Nb, was studied in simulated body fluids by means of the pin-on-disk type wear testing. The mass loss in wear testing increased with increasing the sliding distance. The alpha+beta type titanium alloys, Ti-6Al-4V and Ti-6Al-7Nb, exhibited higher wear resistance than the C.P.Ti. Average size of the wear debris was 4.5 mu m and 3.7 mu m for C.P.Ti and the alpha+beta type titanium alloys, respectively. The elution of metallic constituents into 1 mass% lactic acid solution was detected after the wear test.
Evaluation of Fatigue Property of Titanium Wires by Rotating-bending Testing in 1mass% Lactic Acid Solution 査読有り

T. Narushima, K. Ueda, M. Yamashita, T. Murakami, C. Ouchi, Y. Iguchi

Proc. of International Functional Electrical Stimulation Society 2004　416-418　2004年7月
Boron and nitrogen in GaAs and InP melts equilibrated with B2O3 flux 査読有り

T Yamada, T Kudo, K Tajima, A Otsuka, T Narushima, C Ouchi, Y Iguchi

MATERIALS TRANSACTIONS　45　(4)　1306-1310　2004年4月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.45.1306 　

ISSN：1345-9678

eISSN：1347-5320

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The boron and nitrogen contents of GaAs and InP melts equilibrated with B2O3 flux were examined at 1523 and 1373 K, respectively, using a chemical equilibrium technique. GaAs or InP was melted with B2O3 flux in a silica ampoule with and without a BN crucible. The boron content decreased with increasing nitrogen content in both of the melts equilibrated with B2O3 flux and BN. The solubility product of BN in the melts was expressed as a function of nitrogen content. The relationship between the boron and nitrogen contents of a GaAs melt coexisted with BN agreed well with that in the residue after LEC crystal growth of GaAs. The boron content of the GaAs melt coexisted with silica was much larger than that of the GaAs melt with BN. It was suggested that the reduction of B2O3 by silicon introduced into the melt from silica led the increase of boron content.
Nitridation of Titanium-Tin Alloys during Heating in Air 査読有り

T. Narushima, K. Suzuki, S. Kimura, Y. Iguchi, C. Ouchi

Ti-2003, Science and Technology, Vol.IV　2115-2122　2004年4月
Refinement of beta Grain Size Due to TiB or Y2O3 Precipitates in Titanium Alloy 査読有り

T. Nomura, N. Yamamoto, T. Narushima, Y. Iguchi, C. Ouchi

Ti-2003, Science and Technology, Vol.II　1235-1242　2004年4月
出版者・発行元：Wiley-VCH
Oxidation of boron carbide-silicon carbide composite at 1073 to 1773 K 査読有り

T Narushima, T Goto, M Maruyama, H Arashi, Y Iguchi

MATERIALS TRANSACTIONS　44　(3)　401-406　2003年3月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.44.401 　

ISSN：1345-9678

eISSN：1347-5320

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The oxidation behavior of B4C-(25-60 mol%)SiC composites prepared by arc-melting was investigated in the temperature range of 1073 to 1773 K using a thermogravimetric technique. Liquid borosilicate, solid SiO2 and carbon were identified as oxidation products by X-ray diffraction and Raman spectroscopy. Mass gain was observed during oxidation at 1073 K, while mass loss due to the vaporization of boron oxide in liquid borosilicate was observed at temperatures of 1273 K and higher. In situ Raman spectra of the surface of B4C-SiC composites indicated that the silica concentration in the liquid borosilicate increased with increasing SiC content in the composite. Micro-Raman spectroscopy showed that carbon was enriched in the borosilicate layer close to the oxide/composite interface. The parabolic rate constants for B4C-50 mol%SiC composites at 1073 K were proportional to ambient oxygen partial pressures ranging between 30 and 100 kPa. The diffusion of oxygen molecules through the liquid borosilicate layer could be the rate-controlling process. The increase of SiC content in the B4C-SiC composites improved the oxidation resistance in both the mass gain and mass loss regions.
Wet Oxidation of Silicon Carbide and Silicon Nitride 査読有り

T. Narushima, T. Goto, C. Ouchi, Y. Iguchi

Metals Materials and Processes　15　(1-2)　177-185　2003年1月
Application of Srβ-alumina Solid Electrolyte to a CO2 Gas Sensor 査読有り

T. Goto, G. He, T. Narushima, Y. Iguchi

Solid State Ionics　156　(3-4)　329-336　2003年1月

DOI： 10.1016/S0167-2738(02)00681-1 　

ISSN：0167-2738
Grain refinement of As cast austenite by dynamic recrystallization in HSLA steels 査読有り

N Fujita, T Narushima, Y Iguchi, C Ouchi

ISIJ INTERNATIONAL　43　(7)　1063-1072　2003年
出版者・発行元：IRON STEEL INST JAPAN KEIDANREN KAIKAN
DOI： 10.2355/isijinternational.43.1063 　

ISSN：0915-1559

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Recent progress of steel manufacturing process necessitates to refine an extremely coarse austenitic microstructure evolved in a strand cast steel. Grain refinement of as cast austenite by dynamic recrystallization in HSLA steels was studied by using a hot working simulator. The specimens were prepared from a strand cast slab and the hot rolled steel plate of 0.09%C-1.14%Mn-2.26Ni-0.54Mo-0.045%V steel supplied from a steel plant, and also laboratory heat ingots of 0.14%C-1.45%Mn and 0.14%C-1A5%Mn-0.018%Ti steels. Variations of the true stress-true strain curve and dynamically recrystallized grain size with the deformation temperature, strain rate and the initial gamma grain size were investigated by hot compression test. It was confirmed that dynamically recrystallized grain size in as cast steels was determined simply by steady state flow stress or Zener-Hollomon parameter, but was not influenced by the initial grain size. Austenitic grain size variation with the reheating temperature in the as cast 0.09%C-2.26Ni-Mo-V steel was very small, and flow stress in the as cast Ti-bearing steel was markedly higher compared with those of the hot rolled plate of this steel or the C-Mn steel. These appeared to be caused by grain growth suppression due to the inter-dendritic phase enriched with carbon or alloying elements, and dispersion of the micro segregation region with high hardness, respectively. Finally, the direct hot deformation experiment after levitation melting and solidification was conducted, where the Ti-bearing steel was reheated at the temperature from 1743 to 1773 K and hot deformed by tensile strain at 1523 K. It was confirmed that very coarse gamma grain size in an order of mm was much refined down to 130 to 170 mum by dynamic recrystallization.
Austenitic grain refinement in as cast HSLA steels by dynamic recrystallization 査読有り

N Fujita, T Narushima, Y Iguchi, C Ouchi

THERMEC'2003, PTS 1-5　426-4　1095-1100　2003年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/MSF.426-432.1095 　

ISSN：0255-5476

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Grain refinement of as cast austenite by dynamic recrystallization in HSLA steels was studied by using a hot working simulator. The hot compression and tensile specimens were prepared from 0.14%C-1.45%Mn and 0.018%Ti or 0.078%Zr bearing steels. Variations of the true stress-true strain curve and dynamically recrystallized grain size with the, deformation temperature, strain rate and the initial 7 grain size were investigated by hot compression test. The direct hot deformation experiment after levitation melting and solidification was conducted by using the tensile specimens, where the C-Mn and 0.018%Ti-bearing steels were reheated in the temperature range from 1743 K to 1773 K, cooled by various cooling rates, and then hot deformed by tensile strain at 1423 K to 1523 K. It was confirmed that dynamically recrystallized grain size was determined simply by steady state flow stress or Zener-Hollomon parameter, but was not influenced by the initial gram size. The very coarse 7 grain size with an order of mm was much refined down to 90 to 150 mum by dynamic recrystallization.
Model studies of surfaces and interfaces in ceramics 査読有り

M Kitayama, T Narushima, K Tran, G Gronsky, AM Glaese

ADVANCED CERAMICS AND COMPOSITES　247　341-347　2003年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/KEM.247.341 　

ISSN：1013-9826

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For ceramics, surfaces and interfaces play a critical role in affecting the outcome of processing and sintering. The ultimate performance of ceramics and ceramic-containing composites and devices will also be impacted by surfaces and heterophase interfaces. This paper summarizes the development and application of model experiments for the study of ceramic/vapor and ceramic/metal interfaces. Lithography and etching when combined with solid-state diffusion bonding allow the internalization of controlled-geometry voids, whose morphological evolution can prove information on the coupling between surface energetics (Wulff shapes) and the kinetics of mass flow. Examples from studies - of undoped sapphire and silicon carbide will be presented. We have recently demonstrated that filling the voids with metal prior to diffusion bonding allows the fabrication of arrays of encapsulated, controlled-geometry, metal particles (nickel or copper) within a single crystal ceramic host (sapphire). The potential for using such embedded particles for studies of ceramic/metal interface energetics and shape relaxation kinetics in ceramic/metal systems will be discussed.
Fatigue Property of Stainless Steel FES Electrode in Hanks' Solution 査読有り

Y. Iguchi Yasutaka, T. Narushima, K. Suzuki, S. Yoshida, M. Watanabe, T. Kinami, C. Ouchi

Proc. of International Functional Electrical Stimulation Society 2002　217-219　2002年9月
Oxidation of silicon and silicon carbide in ozone-containing atmospheres at 973 K 査読有り

T Narushima, M Kato, S Murase, C Ouchi, Y Iguchi

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　85　(8)　2049-2055　2002年8月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.2002.tb00402.x 　

ISSN：0002-7820

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The oxidation behavior of a silicon wafer, chemically vapor-deposited SiC, and single-crystal SiC was investigated in an oxygen-2%-7% ozone gas mixture at 973 K. The thickness of the oxide film that formed during oxidation was measured by ellipsometry. The oxidation rates in the ozone-containing atmosphere were much higher than those in a pure oxygen atmosphere. The parabolic oxidation kinetics were observed for both silicon and SiC. The parabolic rate constants varied linearly with the ozone-gas partial pressure. Inward diffusion of atomic oxygen formed by the dissociation of ozone gas through the SiO2 film apparently was the rate-controlling process.
Solubilities and equilibrium distribution coefficients of oxygen and carbon in silicon 査読有り

T Narushima, A Yamashita, C Ouchi, Y Iguchi

MATERIALS TRANSACTIONS　43　(8)　2120-2124　2002年8月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.43.2120 　

ISSN：1345-9678

eISSN：1347-5320

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Solubilities of oxygen and carbon in solid silicon at 1673 K were determined by using a chemical equilibrium technique. Solid silicon was heated at 1673 K in an oxygen atmosphere for 1800 ks, and then oxygen content in the solid silicon equilibrated with silica was measured by the inert gas fusion-IR absorption method. Carbon content in the solid silicon equilibrated with silicon carbide after heating at 1673 K in an Ar-5%CO atmosphere for 4860 ks was measured by the combustion-IR absorption method. Comparing these solubility values in solid silicon with those in liquid silicon that were previously reported by the present authors, the equilibrium distribution coefficients of oxygen and carbon in silicon at the melting point were evaluated to be 0.85 +/- 0.08 and 0.30 +/- 0.16, respectively.
Behavior of oxygen in Ga-As melts with the range of As content up to 5 mass% equilibrated with B2O3 flux 査読有り

K Tajima, T Ogasawara, T Narushima, C Ouchi, Y Iguchi

MATERIALS TRANSACTIONS　42　(11)　2434-2439　2001年11月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.42.2434 　

ISSN：1345-9678

eISSN：1347-5320

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The equilibrium between Ga-As melt, containing arsenic up to 5 mass%, and B2O3 flux was investigated from 1273 to 1523 K in a silica ampoule. The effect of arsenic on equilibrium contents of oxygen, boron and silicon in the melt was investigated. The results were analyzed using interaction parameters. The equilibrium distribution ratio of oxygen between Ga-As melt and B2O3 flux decreased with the increase of temperature, Ga2O3 content in the flux and arsenic content in the melt. The activity of Ga2O3 in the B2O3 flux was determined in the temperature range from 1273 to 1523 K, which is relevant to the practical process of crystal growth of GaAs.
Calorimetric study on hydration of CaO-based oxides 査読有り

Y. Iguchi, T. Narushima, C. Izumi

Journal of Alloys and Compounds　321　(2)　276-281　2001年6月14日

DOI： 10.1016/S0925-8388(01)00970-7 　

ISSN：0925-8388

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Hydration behavior of compounds in Ca-(Si, Al or Fe)-O systems, CaO-(FeO or MnO) solid solutions and various kind of slags were investigated using calorimetric and dilatometric techniques in order to clarify the effects of CaO-based oxides on stability of steelmaking slag. Slow hydration rate and large volume expansion were observed in 3CaO·Al2O3, which was a harmful component for stabilizing slag. Heat of hydration and volume expansion of CaO solid solutions were almost the same as those of pure CaO in lower solute content region than 30-mole%, while the hydration rate decreased as MnO contents increased in higher solute content region. Hydration behavior of converter slag was dominated by free lime contained in the slag. It was suggested that 3CaO·Al2O3 affected hydration behavior of ladle furnace free (LF) slag because Al dissolution was detected after calorimetric measurements and slow expansion rates and higher heat of hydration than that calculated with free lime contents were observed for LF slag. © 2001 Elsevier Science B.V.
High-temperature morphological evolution of lithographically introduced cavities in silicon carbide 査読有り

T Narushima, AM Glaeser

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　84　(5)　921-928　2001年5月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.2001.tb00769.x 　

ISSN：0002-7820

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Internal cavities of controlled geometry and crystallography mere introduced in 6H silicon carbide single crystals by combining lithographic methods, ion-beam etching, and solid-state diffusion bonding. The morphologic evolution of these internal cavities (negative crystals) in response to anneals of up to 128 h duration at 1900 degreesC was examined using optical microscopy. Surface energy anisotropy and faceting had a strong influence on the geometric and kinetic characteristics of evolution. Decomposition of {1210} cavity edges into {101x} facets was observed after 16 h anneals, indicating that (1210) faces are not components of the Wulff shape. The shape evolution kinetics of penny-shaped cavities were also investigated. Experimentally observed evolution rates decreased much more rapidly with those predicted by a model in which surface diffusion was assumed to be rate limiting. This suggested that the development of facets and the associated loss of ledges and terraces during the initial stages of evolution resulted in an evolution process limited by the nucleation rate of attachment/detachment sites (ledges) on the facets.
The Wulff shape of alumina: I. Modeling the kinetics of morphological evolution 査読有り

M Kitayama, T Narushima, WC Carter, RM Cannon, AM Glaeser

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　83　(10)　2561-2571　2000年10月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.2000.tb01591.x 　

ISSN：0002-7820

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The rate at which fully facetted nonequilibrium shaped particles and pores approach their equilibrium (Wulff) shape via surface diffusion was modeled, and calculations relevant to alumina were performed to guide experimental studies. The modeling focuses on 2-D features, and considers initial particle/pore shape, size, surface energy anisotropy, and temperature (surface diffusivity) as variables. The chemical potential differences driving the shape change are expressed in terms of facet-to-facet differences in weighted mean curvature, Two approaches to modeling the surface flux are taken. One linearizes the difference in the mean chemical potential of adjacent facets, and assumes the flux is proportional to this difference. The other approach treats the surface chemical potential as a continuous function of position, and relates the displacement rate of the surface to the divergence of the surface flux. When consistent values for the relevant materials parameters are used, the predictions of these two modeling approaches agree to within a factor of 1.5, As expected, the most important parameters affecting the evolution times are the cross-sectional area (volume in 3-D) and the temperature through its effect on the surface diffusivity, Pores of micrometer size are predicted to reach near-equilibrium shapes in reasonable times at temperatures as low as 1600 degrees C. The detailed geometry of the initial nonequilibrium shape and the Wulff shape appear to have relatively minor effects on the times required to reach a near-equilibrium shape.
The Wulff shape of alumina: II. Experimental measurements of pore shape evolution rates 査読有り

M Kitayama, T Narushima, AM Glaeser

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　83　(10)　2572-2583　2000年10月
出版者・発行元：WILEY-BLACKWELL
DOI： 10.1111/j.1151-2916.2000.tb01592.x 　

ISSN：0002-7820

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The rate at which a facetted tetragonal cavity of nonequilibrium shape approaches a cubic equilibrium (Wulff) shape via surface diffusion was modeled. The shape relaxation rate of a facetted "stretched cylinder" was also modeled, For the first geometry, only an approximate solution based on linearizing the mean potential difference between the source and sink facets was obtained. For the stretched cylinder, both an approximate and an exact solution can be obtained; the approximate solution underestimates the evolution rate by a factor of approximate to 2, To assess the applicability of the models, nonequilibrium shape pores of identical initial geometry (approximate to 20 mu m x 20 mu m x 0.5 mu m) were introduced into (0001), {10 (1) over bar 2}, {11 (2) over bar 0}, and {10 (1) over bar 0} surfaces of sapphire single crystals using microfabrication techniques, ion-beam etching, and hot pressing. The large (approximate to 20 pm x 20 mu m) faces of the pore are low-index surfaces whose nature is dictated by the wafer orientation. A series of anneals was performed at 1900 degrees C, and the approach of the pore shape to an equilibrium shape was monitored, The kinetics of shape evolution are highly sensitive to the crystallographic orientation and stability of the low-index surface that dominates the initial pore shape. The measured variations of the pore aspect ratio were compared to those predicted by the kinetic model. The observations suggest that when the initial bounding surface is unstable, shape relaxation may be controlled by diffusion. However, surface-attachment-limited kinetics (SALK) appears to play a major role in determining the pore shape evolution rate in cases where the initial bounding surfaces have orientations that are part of the Wulff shape.
Sulfidation of Iron and Iron Oxide at 573 to 773 K 査読有り

T.Inaba, M.Sakuma, M.Watanabe, T.Narushima, C.Ouchi, Y.Iguchi

Proceedings of the International Symposium on High-Temperature Corrosion and Protection 2000　143-148　2000年8月
Fatigue Properties of FES Electrodes in Saline Solution 査読有り

M. Watanabe, T. Kinami, T. Narushima, C. Ouchi, Y. Iguchi, Y. Handa, N. Hoshimiya

Proceedings of the International Workshop on FES　24-27　2000年8月
Development of Implanted Bio-materials and Application to FES Electrodes as the Interface between Stimulator and Nerve 査読有り

Y.Iguchi, C.Ouchi, T.Narushima, M.Watanabe, T.Kinami, T.Nishikawa, N.Hoshimiya, Y.Handa

Proceedings of 5th Annual Conference of the International Functional Electrical Stimulation Society　253-256　2000年7月
Collaboration and Technology Transfer between Universities and Industries on Development of Electrodes as the Interface for FES (Functional Electrical Stimulation) 査読有り

Y. Iguchi, T. Narushima, M. Watanabe, T. Kinami, N. Hoshimiya, Y. Handa

Proceedings of The International Conference on Steel and Society (ICSS2000)　396-401　2000年7月
Activity of Ga2O3 in B2O3 flux and standard free energies of formation of GaBO3 and InBO3 査読有り

K Tajima, Y Hino, T Narushima, Y Iguchi

MATERIALS TRANSACTIONS JIM　41　(6)　714-718　2000年6月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.41.714 　

ISSN：0916-1821

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The equilibrium between liquid III group metal and B2O3 flux was investigated thermodynamically as a fundamental study on impurity control in single crystal growth of III-V group compound semiconductors. The oxygen distribution ratio between gallium melt and B2O3 flux and the activity of Ga2O3 in B2O3 Bur were clarified at 1373 and 1273 K by measuring oxygen contents in gallium melt and Ga(2)O(3)contents in B2O3 flux. The standard free energies of formation of GaBO3 and InBO3 were determined by measuring oxygen content of liquid Ill group metal (gallium or indium) equilibrated with B2O3 flux and GaBO3 or InBO3: Delta G degrees(GaBO3) = -1.14 x 10(6) + 251T (J) (T : 1123 similar to 1173 K) Delta G degrees(InBO3) = -1.02 x 10(6) + 220T (J) (T : 1223 similar to 1373 K).
High Temperature CO2 Gas Sensor Using Sr β Alumina 査読有り

G.He, T.Goto, T.Narushima, Y.Iguchi

Proceedings of 4th East Asian Conference on Chemical Sensor　183-186　1999年10月
Electrical Conductivity and Ionic Transport Number of Sr and Ba β-aluminas 査読有り

G.He, T.Goto, T.Narushima, Y.Iguchi

Solid State Ionics　124　(1)　119-124　1999年9月1日
出版者・発行元：None
DOI： 10.1016/S0167-2738(99)00128-9 　

ISSN：0167-2738
Evaluation of Fatigue Properties of High Nitrogen High Manganese Austenite Stainless Steel as an FES Electrode 査読有り

M.Watanabe, T.Narushima, T.Kinami, Y.Iguchi, N.Hoshimiya, Y.Handa

Proceedings of 4th Annual Conference of the IFESS　121　121-123　1999年8月
Electrical Conductivity of Alkaline-Earth Metal β Aluminas and Their Application to a CO2 Gas Sensor 査読有り

G.He, T.Goto, T.Narushima, Y.Iguchi

Solid State Ionics　121　(1)　313-319　1999年
出版者・発行元：None
DOI： 10.1016/S0167-2738(99)00063-6 　

ISSN：0167-2738
BaO-MgO-Al_2O_3におけるBaβ-アルミナの作製とその電気的性質測定

何崗, 成島尚之, 後藤孝, 平井敏雄, 井口泰孝

日本セラミックス協会学術論文誌 : Nippon Seramikkusu Kyokai gakujutsu ronbunshi　106　(1239)　1048-1050　1998年11月1日
出版者・発行元：公益社団法人日本セラミックス協会
DOI： 10.2109/jcersj.106.1048 　

ISSN：1882-1022

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An ionic conductor, Ba β-alumina, was synthesized in a BaO-MgO-Al_2O_3 ternary system by solid state sintering at 2023 to 2073 K. The Ba β-alumina with a composition of BaO : MgO : Al_2O_3 = 1 : 1 : 5 was in a single phase. Its relative density was 96% of the theoretical density. The electrical conductivity of Ba β-alumina was 4.6 × 10^<-3> S・m^<-1> at 1673 K and the activation energy was 126.82 kJ・mol^<-1>. The mobile ion could be Ba^<2+>, and its ionic transport number was about 0.8 to 0.9 at 1073 to 1673 K.
Synthesis and Electrical Property of Baβ-Alumina in a BaO-MgO-Al2O3 System 査読有り

G.He, T.Narushima, T.Goto, T.Hirai, Y.Iguchi

J. Ceram. Soc. Jpn.　106　(11)　1048-1050　1998年11月
出版者・発行元：None
DOI： 10.2109/jcersj.106.1048 　

ISSN：1882-0743

eISSN：1348-6535
Effect of alloying elements on carbon solubility in liquid silicon equilibrated with silicon carbide 査読有り

K Yanaba, Y Matsumura, T Narushima, Y Iguchi

MATERIALS TRANSACTIONS JIM　39　(8)　819-823　1998年8月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.39.819 　

ISSN：0916-1821

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Carbon solubilities in liquid Si-X alloys (where X represents the alloying elements) that have been equilibrated with silicon carbide were determined in the temperature range between 1723 and 1873 K. The Si-X alloy was melted in a silicon carbide crucible under Ar-CO mixture gas flowing. After the equilibrium between the liquid silicon and silicon carbide was established, the carbon content and alloying element (X) content of the quenched sample were measured. The carbon solubility increased as B, Al, P and Ca contents increased in the liquid silicon, but decreased as Ti, V, Cr, Mn, Fe, Co, Ni and Cu contents increased. The effect of the alloying elements on the carbon solubility was discussed thermodynamically.
High-temperature oxidation of CVD silicon carbide -passive/active oxidation and bubble formation 査読有り

T Goto, H Homma, T Hirai, T Narushima, Y Iguchi

HIGH TEMPERATURE CORROSION AND MATERIALS CHEMISTRY, PROCEEDINGS　98　(9)　395-408　1998年
出版者・発行元：ELECTROCHEMICAL SOCIETY INC

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The active oxidation rates of CVD SiC increased with increasing oxygen partial pressure (P-O2) in Ar-O-2 atmosphere, and the active to passive transition happened sharply at a critical P-O2. In CO-CO2 atmosphere, the active oxidation rates showed a maximum at about P-CO2/P-CO=10(-3). With increasing P-CO2/P-CO, the active oxidation changed gradually to the passive oxidation forming a solid phase of SiO2. The Wagner criterion well explained the active to passive transition behavior in both Ar-O-2 and CO-CO2 atmospheres. The passive oxidation kinetics in the temperature range between 1800 and 2000 K was linear with an activation energy of 110 kJ/mol in Ar-O-2, but was parabolic with that of 150 kJ/mol in Ar-CO2. No bubble formation was observed in both Ar-O-2 and Ar-CO2 atmospheres at less than 1990 K.
Sr β-アルミナイオン伝導体の作製とそのa.c.インピーダンス測定

何崗, 早坂祥和, 成島尚之, 後藤孝, 平井敏雄, 井口泰孝

日本セラミックス協会学術論文誌 : Nippon Seramikkusu Kyokai gakujutsu ronbunshi　105　(1228)　1067-1071　1997年12月1日
出版者・発行元：公益社団法人日本セラミックス協会
DOI： 10.2109/jcersj.105.1067 　

ISSN：1882-1022

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β-alumina type ionic conductors were synthesized in the SrO-MgO-Al_2O_3 system by a direct sintering method and their electrical conductivity was measured at 873 to 1373 K by an a.c.impedance method in order to apply the β-alumina to solid electrolyte of a gas sensor at high temperatures. Sr β-aluminas in a single phase were obtained in the composition range of SrO : MgO : Al_2O_3=1 : 1 : 4.8-5.2. The bulk and grain boundary conductivities were separated from the total conductivity at SrO : MgO : Al_2O_3=1 : 1 : 4.8 and 1 : 1 : 5.0. The bulk conductivity of the Sr β-alumina was around 6.7×10^<-3> S・m^<-1> at 1373 K.
Preparation of Srβ-alumina Ionic Conductors and Their Impedance Measurements 査読有り

H.Gang, Y.Hayasaka, T.Narushima, T.Goto, T.Hirai, Y.Iguchi

J. Ceram. Soc. Jpn.　105　(12)　1067-1071　1997年12月
出版者・発行元：None
DOI： 10.2109/jcersj.105.1067 　

ISSN：1882-0743

eISSN：1348-6535
Solubility of carbon in liquid silicon equilibrated with silicon carbide 査読有り

K Yanaba, M Akasaka, M Takeuchi, M Watanabe, T Narushima, Y Iguchi

MATERIALS TRANSACTIONS JIM　38　(11)　990-994　1997年11月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.38.990 　

ISSN：0916-1821

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The solubility of carbon in liquid silicon equilibrated with silicon carbide was determined in the temperature range from 1723 to 1873 K. Silicon was melted in a silicon carbide crucible with an Ar-CO mixture gas flowing. Carbon in silicon was analyzed by the combustion-IR absorption method. The temperature dependence of the carbon solubility in liquid silicon can be represented by the following equation: log (C-(c under bar)/mass%)=3.63-9660/T(+/-0.02) (T:1723-1873 K) The carbon solubility at the melting point of silicon was calculated to be 79 ppm (9.1 x 10(18) atoms.cm(-3)). The level of oxygen impurities in the melt was much lower than that of liquid silicon equilibrated with solid silica. The standard Gibbs free energy change for carbon dissolution in liquid silicon can be represented as: C(s)=(C) under bar C(1 mass%, in liquid silicon) Delta G degrees=7.20x10(4)-11.4Tlog T+6.20T (J).
Oxygen Distribution between Molten B2O3 Flux and Indium or Gallium 査読有り

Y.Iguchi, M.Kinoshita, Y.Hino, T.Narushima

Proc. of 5th Int. Conf. on Molten Slags, Fluxes and Salts　317-320　1997年1月
Determination of Free Lime Contents in Slags by Solution Calorimetry 査読有り

Y.Muraki, T.Narushima, Y.Iguchi

ISIJ International　36　(12)　243-246　1996年12月
出版者・発行元：The Iron and Steel Institute of Japan
DOI： 10.2355/isijinternational.36.Suppl_S243 　

ISSN：0915-1559

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Free lime content in slag was investigated using a solution calorimetric technique in order to clarify hydration behavior of the free lime. After confirmation of the agreement between the heat of hydration of pure CaO obtained by this method and the calculated value, the heats of hydration of slags with different free lime contents were measured. Good correlation between the free lime contents and the heats of the hydration was indicated though small amounts of calcium silicates, calcium aluminates, MgO and calcium ferrite in the slags might be hydrated in addition to the free lime.
High-Temperature Oxidation of CVD Silicon-Based Ceramics 査読有り

T.Goto, T.Hirai, T.Narushima, Y.Iguchi

Ceramic Transaction　71　245-257　1996年10月
Oxygen Distribution between Molten III Group Metals and B2O3 Flux 査読有り

Y.Iguchi, M.Kinoshita, D.Sajuti, S.Yoshida, Y.Hino, T.Narushima

Proc. of Int. Symp. on Metall. and Mater. of Non-Ferrous Metals and Alloys　45-49　1996年10月
In situ observation of oxide films formed during thermal oxidation of SiC-B4C composite using Raman spectroscopy 査読有り

T Narushima, M Maruyama, H Arashi, T Goto, T Hirai, Y Iguchi

CORROSION OF ADVANCED CERAMICS　113　99-104　1996年
出版者・発行元：TRANS TECH PUBLICATIONS LTD
DOI： 10.4028/www.scientific.net/KEM.113.99 　

ISSN：1013-9826

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Oxidation behaviour of SiC-B4C composites at 1073 K was investigated by laser Raman spectroscopy. In situ Raman spectra of the surface of the composite indicated the formation of carbon and borosilicate as oxidation products. The carbon was enriched in the part of borosilicate closer to the oxide/composite interface using a micro-Raman spectroscopic system. The oxidation resistance of the composites was improved with increasing SiC content.
Complex oxide films formed during thermal oxidation of liquid aluminum alloys 査読有り

Y Iguchi, T Narushima, M Marauyama, T Shiozawa, H Arashi

DESIGN FUNDAMENTALS OF HIGH TEMPERATURE COMPOSITES, INTERMETALLICS, AND METAL-CERAMICS SYSTEMS　337-343　1996年
出版者・発行元：MINERALS, METALS & MATERIALS SOC
High-Temperature Oxidation Behavior of CVD SiC and Si3N4 査読有り

T.Goto, T.Hirai, T.Narushima, Y.Iguchi

Proc. 95' Beijing Inter. Conf. for Surface Science and Engineering　401-406　1995年9月
OXYGEN SOLUBILITY IN LIQUID SI-X (X=SB, B, P AND AS) ALLOYS 査読有り

T NARUSHIMA, K MATSUZAWA, M MAMIYA, Y IGUCHI

MATERIALS TRANSACTIONS JIM　36　(6)　763-769　1995年6月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.36.763 　

ISSN：0916-1821

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Oxygen solubilities in liquid Si-X (X=Sb, B, P and As) alloys equilibrated with solid silica (cristobalite) were determined in the temperature range between 1693 and 1823 K. Si-X alloys were melted in a silica crucible with oxygen gas flowing. After the equilibrium between a silicon melt and silica was established, the contents of oxygen and the alloying elements (X) in the silicon melt were determined. It was found that the oxygen solubility increased with increasing alloying element in the melt. The effect of the alloying elements on the oxygen solubility was discussed thermodynamically.
ラマン分光法を用いた高温酸化皮膜の "その場" 観察装置の開発査読有り

成島尚之, 菊池直樹, 丸山誠, 嵐治夫, 仁科雄一郎, 井口泰孝

鉄と鋼　81　(6)　607-612　1995年6月
出版者・発行元：None
DOI： 10.2355/tetsutohagane1955.81.6_607 　

ISSN：0021-1575
CVD炭化ケイ素および窒化ケイ素の高温酸化挙動査読有り

後藤孝, 成島尚之, 井口泰孝, 平井敏雄

第6回超耐環境性先進材料シンポジウム講演集　331-338　1995年
溶融ガリウムおよびインジウムの酸素溶解度査読有り

成島尚之, ジュスマンサユティ, 佐伯勝之, 吉田真哉, 井口泰孝

日本金属学会誌　59　(1)　37-43　1995年1月
出版者・発行元：None
DOI： 10.2320/jinstmet1952.59.1_37 　

ISSN：0021-4876

eISSN：1880-6880
HIGH-TEMPERATURE OXIDATION OF CHEMICALLY VAPOR-DEPOSITED SILICON-NITRIDE IN A CARBON-MONOXIDE CARBON-DIOXIDE ATMOSPHERE 査読有り

T NARUSHIMA, T GOTO, J HAGIWARA, Y IGUCHI, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　77　(11)　2921-2925　1994年11月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1994.tb04525.x 　

ISSN：0002-7820

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Oxidation behavior of chemically vapor-deposited silicon nitride (CVD-Si3N4) in CO-CO2 atmospheres between 1823 and 1923 K was investigated using a thermogravimetric technique. Mass loss of Si3N4 (active oxidation) was observed in a region of P-CO2/P-CO < 1, while mass gain (passive oxidation) was observed at around P-CO2/P-CO 10. In the active oxidation region below P-CO2/P-CO 10(-4), carbon particles were formed on the Si3N4 surface as an oxidation product, and the mass-loss rates were independent of P-CO2/P-CO. In the active oxidation region above P-CO2/P-CO 10(-4), the mass-loss rates decreased with increasing P-CO2/P-CO. The critical P-CO2/P-CO value from the active to passive oxidation was 2 orders of magnitude larger than the calculated value predicted from the Wagner model.
NITROGEN SOLUBILITY IN LIQUID SILICON 査読有り

T NARUSHIMA, N UEDA, M TAKEUCHI, F ISHII, Y IGUCHI

MATERIALS TRANSACTIONS JIM　35　(11)　821-826　1994年11月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.35.821 　

ISSN：0916-1821

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The nitrogen solubility in,liquid silicon equilibrated with beta-Si3N4 was determined in the temperature range between 1723 and 1873 K. A silicon nitride crucible and an N-2-H-2 atmosphere (N-2:H-2=4:1, total pressure=0.1 MPa) were employed for the melting of silicon to secure the Si(1)/Si3N4(s) equilibrium. Nitrogen in silicon was analyzed by the Kjeldahl method. The temperature dependence of nitrogen solubility (C ($) under bar($) under bar N) in liquid silicon was represented by the following equation: log (C-$ under bar N/mass%)=2.410-9759s/T (+/-0.24) (T:1723-1873 K). Since oxygen contents in the silicon melt were much smaller than the oxygen solubility, the effect of oxygen in liquid silicon on the nitrogen solubility could be ignored. The nitrogen solubility at the melting point of silicon (1685 K) by extrapolation was around 4 ppm (4 x 10(17) atoms cm(-3)), which was one order of magnitude smaller than the literature values reported previously. The standard free energy change for nitrogen dissolution could be represented as: 1/2N(2)=($) under bar N(mass%, in liquid silicon), Delta G degrees= -4.45 x 10(4)+66.4T(J). The correlation between the standard enthalpy change for nitrogen dissolution in liquid silicon and the standard enthalpy of formation of silicon nitride at 298 K per mol of nitrogen agreed with those for other liquid metals. Therefore, the values of nitrogen solubility obtained in the present work were considered to be
HIGH-TEMPERATURE ACTIVE OXIDATION AND ACTIVE-TO-PASSIVE TRANSITION OF CHEMICALLY VAPOR-DEPOSITED SILICON-NITRIDE IN N-2 O-2 AND AR O-2 ATMOSPHERES 査読有り

T NARUSHIMA, T GOTO, Y YOKOYAMA, J HAGIWARA, Y IGUCHI, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　77　(9)　2369-2375　1994年9月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1994.tb04607.x 　

ISSN：0002-7820

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The oxidation behavior of chemically vapor-deposited silicon nitride in N-2-O-2 acid Ar-O-2 atmospheres was studied using a thermogravimetric technique at temperatures 1823 to 1923 K. Active oxidation was observed at low oxygen partial pressures. The active oxidation rates increased with increasing oxygen partial pressure (P-O2) up to a certain P-O2 and then passive oxidation occurred. The transition oxygen partial pressures from active to passive oxidation were determined. The rate-controlling step for the active oxidation could be oxygen diffusion through a gaseous boundary layer near the S3N4 surface. Decomposition of SI3N4 does not seem to be associated with the mass loss behavior. The Wagner model was employed to explain the oxidation behavior.
High-Temperature Passive/Active Oxidation for CVD SiC and Si3N4 査読有り

T.Goto, T.Narushima, Y.Iguchi, T.Hirai

Ceramic Transactions　42　307-318　1994年8月
OXYGEN SOLUBILITY IN LIQUID SILICON 査読有り

T NARUSHIMA, K MATSUZAWA, Y MUKAI, Y IGUCHI

MATERIALS TRANSACTIONS JIM　35　(8)　522-528　1994年8月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.35.522 　

ISSN：0916-1821

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The oxygen solubility in liquid silicon equilibrated with solid silica (cristobalite) was determined in the temperature range between 1693 and 1823 K. Silicon was melted in a silica crucible with oxygen gas flowing. Oxygen in a quenched sample was analyzed by the inert gas fusion-IR absorption method. The optimum furnace power and bath composition for oxygen extraction were determined. The temperature dependence of oxygen solubility in liquid silicon could be expressed as the following equation. log (C-O under bar/mass%)= -4620/T+0.332(+/-0.06)(T:1693 similar to 1823 K) The oxygen solubility in liquid silicon at the melting point (1685 K) was calculated to be 39 ppm (3.4 x 10(18) atoms . cm(-3)). Using the temperature dependence of oxygen solubility in the present work and the standard free energy of formation of silica in the literature, the standard free energy change follows: 1/2O(2)(g)=(O) under bar(mass%, in liquid silicon) Delta G degrees= -3.88 x 10(5)+95.6 T(J) According to the previously reported correlations between the standard enthalpy change for oxygen dissolution in liquid metals and the standard enthalpy of the formation of the metal oxides at 298 K per mol of oxygen, and the standard enthalpy change and the standard entropy change for oxygen dissolution in liquid metals, it was suggested that the present Delta G degrees value, i.e., the oxygen solubility in liquid silicon, was reasonable.
Theoretical estimation of the effect of minor elements on the solubility of oxygen in silicon melt 査読有り

Y. Waseda, K. T. Jacob, Y. Iguchi, T. Narushima

Journal of Crystal Growth　139　(3-4)　357-362　1994年5月2日

DOI： 10.1016/0022-0248(94)90188-0 　

ISSN：0022-0248

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The effect of fourteen minor elements (Al, As, B, Bi, C, Ga, Ge, In, N, P, Pb, S, Sb and Sn) on the solubility of oxygen in silicon melt has been estimated using a recently developed theoretical equation, with only fundamental physical parameters such as hard sphere diameter, atomic volume and molar heat of solution at infinite dilution as inputs. The results are expressed in the form of interaction parameters. Although only limited experimental data are available for comparison, the theoretical approach appears to predict the correct sign, but underestimates the magnitude of the interaction between oxygen and alloying elements. The present theoretical approach is useful in making qualitative predications on the effect of minor elements on the solubility of oxygen in silicon melt, when direct measurements are not available. © 1994.
ACTIVE-TO-PASSIVE TRANSITION AND BUBBLE FORMATION FOR HIGH-TEMPERATURE OXIDATION OF CHEMICALLY VAPOR-DEPOSITED SILICON-CARBIDE IN CO-CO2 ATMOSPHERE 査読有り

T NARUSHIMA, T GOTO, Y YOKOYAMA, M TAKEUCHI, Y IGUCHI, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　77　(4)　1079-1082　1994年4月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1994.tb07273.x 　

ISSN：0002-7820

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Oxidation behavior of chemically vapor-deposited SiC in CO-CO2 atmospheres (0.1 MPa) was investigated using a thermogravimetric technique at temperatures from 1823 to 1923 K. Active or passive oxidation was observed depending on temperature and CO2/CO partial pressure ratio (P(CO2)/P(CO)). The critical P(CO2)/P(CO) value for the transition was 10(2) times as large as a theoretical value calculated from the Wagner model. In the passive oxidation above 1873 K, SiO2 bubbles were grown. The expansion and rupture of bubbles caused cyclic rapid mass gain and mass loss.
CVD炭化ケイ素のアクティブ／パッシブ酸化挙動査読有り

後藤孝, 成島尚之, 井口泰孝, 平井敏雄

第５回超耐環境性先進材料シンポジウム講演集　375-382　1994年
ACTIVE TO PASSIVE TRANSITION IN THE HIGH-TEMPERATURE OXIDATION OF CVD SIC AND SI3N4 査読有り

T GOTO, T NARUSHIMA, Y IGUCHI, T HIRAI

CORROSION OF ADVANCED CERAMICS　267　165-176　1994年
出版者・発行元：KLUWER ACADEMIC PUBL
ISSN：0168-132X
HIGH-TEMPERATURE ACTIVE OXIDATION OF CVD-SI3N4 IN N2-O2 ATMOSPHERE 査読有り

T NARUSHIMA, J HAGIWARA, N KIKUCHI, Y IGUCHI, T GOTO, T HIRAI

ADVANCED MATERIALS '93, I - A & B　14　(A & B)　281-284　1994年
出版者・発行元：ELSEVIER SCIENCE PUBL B V
PHASE-DIAGRAMS OF THE GA2O3-B2O3 AND IN2O3-B2O3 BINARY-SYSTEMS 査読有り

D SAJUTI, M YANO, T NARUSHIMA, Y IGUCHI

MATERIALS TRANSACTIONS JIM　34　(12)　1195-1199　1993年12月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.34.1195 　

ISSN：0916-1821

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The solubility of Ga2O3 or In2O3 in liquid B2O3 which is used as a flux for pulling single crystal of III-V compounds has been measured by the sampling method in the temperature range of 973 to 1573 K. The gallium or indium contents in the samples were analyzed by ICP atomic emission spectroscopy. The phase equilibrium in the Ga2O3-B2O3 or In2O3-B2O3, binary system has been determined by X-ray diffraction and differential thermal analysis for the precipitates in liquid phase or the binary compounds which were synthesized from pure oxides. The solid phase equilibrated with liquid phase was clarified. The phase diagrams of the Ga2O3-B2O3 and In2O3-B2O3 binary systems were constructed.
HIGH-TEMPERATURE ACTIVE OXIDATION OF CHEMICALLY VAPOR-DEPOSITED SILICON-CARBIDE IN CO-CO2 ATMOSPHERE 査読有り

T NARUSHIMA, T GOTO, Y YOKOYAMA, Y IGUCHI, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　76　(10)　2521-2524　1993年10月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1993.tb03975.x 　

ISSN：0002-7820

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Active oxidation behavior of CVD-SiC in CO-CO2 atmospheres was investigated using a thermogravimetric technique in the temperature range between 1823 and 1923 K. The gas pressure ratio, P(CO2)/P(CO), was controlled between 10(-4) and 10(-1) at 0.1 MPa. Active oxidation rates (mass loss rates) showed maxima at a certain value of P(CO2)/P(CO), (P(CO2)/P(CO))*. In a P(CO2)/P(CO) region lower than the (P(CO2)/P(CO))*, a carbon layer was formed on the SiC surface. In a P(CO2)/P(CO) region higher than the (P(CO2)/P(CO))*, silica particles or a porous silica layer was observed on the SiC surface.
OXIDATION OF CHEMICALLY VAPOR-DEPOSITED SILICON-NITRIDE IN DRY OXYGEN AT 1923-K TO 2003-K 査読有り

T NARUSHIMA, RY LIN, Y IGUCHI, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　76　(4)　1047-1051　1993年4月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1993.tb05333.x 　

ISSN：0002-7820

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Oxidation of chemically vapor-deposited Si3N4 was studied in dry oxygen between 1923 and 2003 K under a total pressure of 0.1 MPa using a thermogravimetric technique. At 1923 to 1953 K, a parabolic rate mechanism prevailed for the oxidation reaction. From 1973 K, the oxidation reaction exhibited a mixed linear-parabolic rate mechanism. At 2003 K, on the other hand, the oxidation of Si3N4 showed a linear behavior. Both amorphous silica and cristobalite were identified as reaction products on the oxidized Si3N4 surface using X-ray diffraction analysis. The percentage of cristobalite in the surface oxide scale was determined from the X-ray diffraction pattern. It was found that, at 2003 K, only amorphous silica was formed. The parabolic rate constants (K(p)) obtained from this study were close to those obtained in the literature.
SOLUBILITY OF OXYGEN, NITROGEN AND CARBON IN LIQUID SILICON 査読有り

Y IGUCHI, T NARUSHIMA

FIRST INTERNATIONAL CONFERENCE ON PROCESSING MATERIALS FOR PROPERTIES　437-440　1993年
出版者・発行元：MINERALS, METALS & MATERIALS SOC
Solubility of Ga2O3 or In2O3 in Liquid B2O3 査読有り

D.Sajuti, M.Yano, T.Narushima, Y.Iguchi

Proceedings of the 4th International Conference on Molten Slags and Fluxes　614-619　1992年6月
HIGH-TEMPERATURE OXIDATION OF CVD-SIC IN CO-CO2 ATMOSPHERE 査読有り

T NARUSHIMA, T GOTO, Y IGUCHI, T HIRAI

HIGH TEMPERATURE CORROSION OF ADVANCED MATERIALS AND PROTECTIVE COATINGS　345-350　1992年
出版者・発行元：NORTH HOLLAND, ELSEVIER SCIENCE PUBL BV
High-temperature active oxidation of CVD-Si3N4 in ArO2 atmosphere 査読有り

Takayuki Narushima, Yasutaka Iguchi, Takashi Goto, Toshio Hirai, Yoshio Yokoyama

Solid State Ionics　53-56　(1)　265-269　1992年

DOI： 10.1016/0167-2738(92)90389-7 　

ISSN：0167-2738

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Active oxidation of CVD-Si3N4 in ArO2 atmospheres was investigated at temperatures from 1823 to 1923 K. Active oxidation rates increased with increasing oxygen partial pressure, temperature and total gas flow rate. The rate-controlling step for active oxidation is oxygen diffusion through a gaseous boundary layer. The transition from active to passive oxidation was observed at a certain oxygen partial pressure. The transition behavior is discussed using Wagner's model. © 1992.
HIGH-TEMPERATURE ACTIVE OXIDATION OF CHEMICALLY VAPOR-DEPOSITED SILICON-CARBIDE IN AN AR-O-2 ATMOSPHERE 査読有り

T NARUSHIMA, T GOTO, Y IGUCHI, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　74　(10)　2583-2586　1991年10月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1991.tb06803.x 　

ISSN：0002-7820

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Active oxidation behavior of chemically vapor-deposited silicon carbide in an Ar-O2 atmosphere at 0.1 MPa was examined in the temperature range between 1840 and 1923 K. The transition from active oxidation (mass loss) to passive oxidation (mass gain) was observed at certain distinct oxygen partial pressures (P(O2)t). The values of P(O2)t increased with increasing temperature and with decreasing total gas flow rates. This behavior was well explained by Wagner's model and thermodynamic calculations. Active oxidation rates (K(a)) increased with increasing O2 partial pressures and total gas flow rates. The rate-controlling step of the active oxidation was concluded to be O2 diffusion through the gaseous boundary layer.
HIGH-TEMPERATURE OXIDATION OF CHEMICALLY VAPOR-DEPOSITED SILICON-CARBIDE IN WET OXYGEN AT 1823 TO 1923-K 査読有り

T NARUSHIMA, T GOTO, Y IGUCHI, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　73　(12)　3580-3584　1990年12月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1990.tb04261.x 　

ISSN：0002-7820

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The oxidation of chemically vapor-deposited SiC in wet O2 (water vapor partial pressure = 0.01 MPa, total pressure = 0.1 MPa) was examined using a thermogravimetric technique in the temperature range of 1823 to 1923 K. The oxidation kinetics follow a linear-parabolic relationship over the entire temperature range. The activation energies of linear and parabolic rate constants were 428 and 397 kJ.mol-1, respectively. The results suggested that the rate-controlling step is a chemical reaction at an SiC/SiO2 interface in the linear oxidation regime, and the rate-controlling step is an oxygen diffusion process through the oxide film (cristobalite) in the parabolic oxidation regime.
HIGH-TEMPERATURE PASSIVE OXIDATION OF CHEMICALLY VAPOR-DEPOSITED SILICON-CARBIDE 査読有り

T NARUSHIMA, T GOTO, T HIRAI

JOURNAL OF THE AMERICAN CERAMIC SOCIETY　72　(8)　1386-1390　1989年8月
出版者・発行元：AMER CERAMIC SOC
DOI： 10.1111/j.1151-2916.1989.tb07658.x 　

ISSN：0002-7820
Active to Passive Transition in the Oxidation of CVD-SiC 査読有り

T. Narushima, T. Goto, T. Hirai

Proc. the Materials Research Society International Meeting on Advanced Materials　4　295-300　1989年4月

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MISC 90

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表面技術　72　(11)　616-621　2021年11月
出版者・発行元：The Surface Finishing Society of Japan
DOI： 10.4139/sfj.72.616 　

ISSN：0915-1869

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チタンへの骨適合性コーティング招待有り査読有り

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Mitsuo Niinomi, Takao Hanawa, Takayuki Narushima, Takayoshi Nakano, Masahiko Ikeda

MATERIALS TRANSACTIONS　57　(12)　1985-1985　2016年
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MPR2016905 　

ISSN：1345-9678

eISSN：1347-5320
The role of niobium ions in calcium phosphate invert glasses for bone regeneration

A. Obata, H. Maeda, K. Ueda, T.Narushima, T. Kasuga

Phosphorus Research Bulletin　30　30-34　2015年12月31日
出版者・発行元：日本無機リン化学会
DOI： 10.3363/prb.30.3 　

ISSN：0918-4783

詳細を見る詳細を閉じる

Abstract: Phosphate invert glasses (PIGs) containing niobium were prepared by a conventional melt-quenching method and the structures and chemical durability of the glasses and osteoblast-like cell responses to them were examined. Raman and solid state 31 P NMR spectra of the glasses demonstrated that two types of niobate groups, NbO4 and NbO6 units, were contained in the glasses and prepared to combine to pyrophosphate structure than orthophosphate one. The chemical durability in Tris-HCl solution was increased with the increase in the niobium content in the glasses, since niobium replaced to phosphorus and contributed to the formation of P-O-Nb and Nb-O-Nb bonds, which are stronger than P-O-P bond. The niobium ions released from the glasses enhanced the differentiation and mineralization of the cells, rather than the initial adhesion and proliferation. The upregulation of these cell functions by the niobium ions possessed doze-dependence; the medium containing 1 x 10-7 M of the ions exhibited the highest levels of the cell functions.
超高齢社会でのQOL向上に貢献するバイオマテリアル研究

成島尚之

Kawaijuku Guideline 2015　(11)　68-69　2015年11月15日
金属系バイオマテリアルにおける表面改質

成島尚之

メカニカルサーフェス・テック　(028)　20-22　2015年10月25日
出版者・発行元：メカニカル・テック社
チタンおよびチタン合金

新家光雄, 池田勝彦, 小林郁夫, 成島尚之

軽金属　65　(8)　377-380　2015年8月1日
出版者・発行元：軽金属学会
ISSN：0451-5994
金属系バイオマテリアルの表面・組織制御(特別講演2,Dental Materials Adviser/Senior Adviser特別セミナー,第65回日本歯科理工学会学術講演会)

成島尚之

日本歯科理工学会誌　34　(2)　127-127　2015年3月25日
出版者・発行元：一般社団法人日本歯科理工学会
ISSN：1884-4421
リン酸カルシウムコーティングによる骨組織伝導

上田恭介, 成島尚之

骨形態計測学会誌　24　(1)　24-31　2014年1月
チタンの熱酸化を利用した生体用表面処理

成島尚之, 上田恭介, 佐渡翔太

材料と環境　63　(5)　295-300　2014年
出版者・発行元：Japan Society of Corrosion Engineering
DOI： 10.3323/jcorr.63.295 　

ISSN：1881-9664 0917-0480
セラミックスコーティングによる金属系バイオマテリアル表面の高機能化

成島尚之, 上田恭介, 佐渡翔太

機能材料　33　(9)　33-39　2013年9月1日
出版者・発行元：シーエムシー出版
ISSN：0286-4835
Special Issue on New Functions and Properties of Engineering Materials Created by Designing and Processing II PREFACE

Mitsuo Niinomi, Tadashi Furuhara, Akihiko Chiba, Takayuki Narushima

MATERIALS TRANSACTIONS　54　(8)　1241-1241　2013年8月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans.MPR2013904 　

ISSN：1345-9678

eISSN：1347-5320
チタンの軽元素メタラジー

成島尚之

チタン　61　(2)　126-131　2013年4月1日
Precipitates in Biomedical Co-Cr Alloys

Takayuki Narushima, Shingo Mineta, Yuto Kurihara, Kyosuke Ueda

JOM　65　(4)　489-504　2013年4月
出版者・発行元：SPRINGER
DOI： 10.1007/s11837-013-0567-6 　

ISSN：1047-4838

詳細を見る詳細を閉じる

Herein, precipitates in biomedical Co-Cr-Mo and Co-Cr-W-Ni alloys are reviewed with a focus on their phase, chemical composition, morphology, and formation/dissolution during heat treatment. The effects of the heat-treatment conditions and the addition of minor alloying elements such as carbon, nitrogen, Si, and Mn on the precipitates are also discussed. Mostly, the precipitates in the alloys are of the sigma-phase, M23X6-type phase, eta-phase (M6X-M12X type), pi-phase (M2T3X type), chi-phase, M7X3-type phase, or M2X-type phase (M and T refer to metallic elements, and X refers to carbon and/or nitrogen); the sigma- and chi-phases are intermetallic compounds, and the others are carbides, nitrides, and carbonitrides. The dissolution of the precipitates during solution treatment is delayed by the formation of the pi-phase at temperatures where partial melting occurs in the alloys. In addition, the stability of the precipitates depends on the content of minor alloying elements. For example, the addition of carbon enhances the formation of M23X6-type and M7X3-type precipitates. Nitrogen stabilizes the M2X-type, eta-phase, and pi-phase precipitates, and Si stabilizes the eta-phase and chi-phase precipitates. The balance between the minor alloying element abundances also affects the constitution of the precipitates in Co-Cr alloys.
TNTZ製インプラントの有効性と, RFマグネトロンスパッタリングによる表面改質の効果に関する検討

白石成, 成島尚之, 後藤孝, 新家光雄, 鈴木治, 佐々木啓一

日本歯科理工学会誌 = The journal of the Japanese Society for Dental Materials and Devices　31　(5)　385-385　2012年9月25日
出版者・発行元：一般社団法人日本歯科理工学会
ISSN：1884-4421

詳細を見る詳細を閉じる

Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) has excellent advantages as a biomaterial, such as low Young's modulus, low cytotoxicity, and the absence of allergens. However, it is unclear whether TNTZ can achieve sufficient osseointegration as a dental implant. The effectiveness of surface modification of TNTZ implants with amorphous calcium phosphate (ACP) by radiofrequency (RF) magnetron sputtering is also unclear. We investigated the biomechanical behaviors of TNTZ implants in vivo. The results suggest that TNTZ implants can achieve osseointegration similar to that of pure Ti, and that surface modification with ACP by RF magnetron sputtering improves osseointegration.
東北支部のあゆみ

新家光雄, 成島尚之

軽金属　61　(11)　605-606　2011年11月30日

ISSN：0451-5994
チタンおよびチタン合金

新家光雄, 池田勝彦, 成島尚之

軽金属　61　(11)　673-677　2011年11月1日
Research and Development of Metallic Biomaterials in Japan

T. Narushima

Proceeding: 4th NATIONAL SEMINAR of METALLURGY and MATERIAL　11-24　2010年7月
Special Issue on Low-Cost Reduction Processes, Roles of Low-Cost Elements and Interstitial Elements, and Microstructural Control for Generalization of Titanium Alloys PREFACE

Mitsuo Niinomi, Takao Hanawa, Masahiko Ikeda, Akihiko Chiba, Tadashi Furuhara, Takayuki Narushima, Koichi Tsuchiya, Satoshi Emura, Takayoshi Nakano, Toshihide Takenaka

MATERIALS TRANSACTIONS　50　(12)　2703-2703　2009年12月
出版者・発行元：JAPAN INST METALS
ISSN：1345-9678

eISSN：1347-5320
新しい用途展開（Ⅳ）生体医療用途

成島尚之

第61回白石記念講座「ユビキタス時代に向けたチタンの元素戦略」　125-142　2009年10月9日
出版者・発行元：日本鉄鋼協会
Special Issue on New Functions and Properties of Engineering Materials Created by Designing and Processing PREFACE

Masahiko Morinaga, Mitsuo Niinomi, Tadashi Furuhara, Akihiko Chiba, Takayuki Narushima

MATERIALS TRANSACTIONS　50　(7)　1612-1612　2009年7月
出版者・発行元：JAPAN INST METALS
ISSN：1345-9678

eISSN：1347-5320
S109 ブラスト処理Ti-6Al-4V基板へのリン酸カルシウムコーティングと生体内外評価(力学適応能,自己組織化能を有するバイオマテリアル-生体インターフェイスの創製,SP1:シンポジウム1)

成島尚之, 上田恭介, 後藤孝, 栗原淳, 中川浩伸, 川村仁

バイオエンジニアリング講演会講演論文集　2008　(0)　331-332　2009年
出版者・発行元：一般社団法人日本機械学会
S111 CVD法により合成したCa-P-O膜の骨形成に及ぼす微細組織の影響(力学適応能,自己組織化能を有するバイオマテリアル-生体インターフェイスの創製,SP1:シンポジウム1)

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

バイオエンジニアリング講演会講演論文集　2008　(0)　335-336　2009年
出版者・発行元：一般社団法人日本機械学会
J0401-2-3 チタン基板上に作製したリン酸カルシウムコーティング膜評価(生体材料およびその表面改質材(2))

上田恭介, 川崎雄城, 成島尚之, 後藤孝, 栗原淳, 川村仁

年次大会講演論文集　2009　(0)　271-272　2009年
出版者・発行元：一般社団法人日本機械学会
DOI： 10.1299/jsmemecjo.2009.6.0_271 　

詳細を見る詳細を閉じる

Amorphous calcium phosphate (ACP), oxyapatite (Ca_<10>(PO_4)_6O, OAp), heat-treated OAp (OAp-AIR) and OAp/OAp-AIR double layer (D-layer) coating films were fabricated on the surface of the titanium substrates using RF magnetron sputtering. The cross sectional observation before and after the implantation, bonding strength between coating film and substrates and removal torques from femur of Japanese white rabbits were examined. The bonding strength between coating films and substrates were more than 50 MPa, and removal torque of coated implants from the femur of Japanese white rabbits were greater than that of uncoated one. After the implantation of ACP coating film, the coating would be dissolved into the body and it caused the high biocompatibility of bone.
Deoxidation of NiTi Alloy Melts Using Metallic Barium (vol 49, pg 289, 2008)

Susumu Miyamoto, Masatoshi Watanabe, Takayuki Narushima, Yasutaka Iguchi

MATERIALS TRANSACTIONS　49　(12)　2922-2922　2008年12月
出版者・発行元：JAPAN INST METALS
ISSN：1345-9678

eISSN：1347-5320
Strategy for ubiquitous titanium alloys

Mitsuo Niinomi, Takao Hanawa, Masahiko Ikeda, Akihiko Chiba, Tadashi Furuhara, Takayuki Narushima, Koichi Tsuchiya, Satoshi Emura, Takayoshi Nakano, Toshihide Takenaka

Nippon Kinzoku Gakkaishi/Journal of the Japan Institute of Metals　72　(12)　915　2008年12月

DOI： 10.2320/jinstmet.72.915 　

ISSN：0021-4876
骨適合性向上を目的としたチタン材料の表面処理

成島尚之

軽金属　58　(11)　577-582　2008年11月

DOI： 10.2464/jilm.58.577 　

ISSN：0451-5994
レーザーCVD法により合成したリン酸カルシウム膜のアパタイト形成能

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　142nd　2008年

ISSN：1342-5730
レーザーCVD法により合成したHAp膜上へのアパタイト形成の結晶配向依存性

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　143rd　2008年

ISSN：1342-5730
リン酸カルシウムコーティングを施したチタン材料の生体内外評価

成島尚之

大会講演概要　113　59-60　2007年10月10日
表面処理：金属バイオマテリアルの表面形態制御と表面組成・相制御

成島尚之

バイオマテリアル　25　(3)　252-260　2007年8月
金属バイオマテリアルの表面形態制御と表面組成・相制御

成島尚之

バイオマテリアル : 生体材料 : Journal of Japanese Society for Biomaterials　25　(4)　252-260　2007年7月15日
出版者・発行元：日本バイオマテリアル学会
ISSN：1347-7080
PREFACE

HOSODA Hideki, NAKANO Takayoshi, NARUSHIMA Takayuki, HANAWA Takao, NIINOMI Mitsuo, MIYAZAKI Shuichi

Materials transactions　48　(3)　277-277　2007年3月1日

ISSN：1345-9678
Special Issue on smart and harmonic biomaterials

Hideki Hosoda, Takayoshi Nakano, Takayuki Narushima, Takao Hanawa, Mitsuo Niinomi, Shuichi Miyazaki

MATERIALS TRANSACTIONS　48　(3)　277-277　2007年3月
出版者・発行元：JAPAN INST METALS
ISSN：1345-9678

eISSN：1347-5320
生体用チタン及びチタン合金

成島尚之

金属　77　(2)　122-127　2007年2月
MOCVD法によるCa-Ti-OおよびCa-P-O傾斜機能バイオセラミックス膜の合成

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

粉体粉末冶金協会講演概要集　2007　2007年
MOCVD法により合成したCa-P-O膜上への擬似体液中におけるアパタイト形成

佐藤充孝, TU R., 後藤孝, 上田恭介, 成島尚之

セラミックス基礎科学討論会講演要旨集　45th　2007年
MOCVD法により合成したCa-P-O膜の擬似体液中におけるHAp形成

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　140th　2007年

ISSN：1342-5730
Effect of oxygen partial pressure on electrical conductivity of Ca-Ru-O compounds prepared by spark plasma sintering

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

Materials Science Forum　561-565　(0)　595-598　2007年
PIXE法による細胞培養液とチタンイオン貪食マクロファージRAW264の元素分析

平雅之, 佐々木かおり, 斉藤設雄, 根津尚史, 荒木吉馬, 成島尚之

歯科材料・器械　25　(2)　181-181　2006年4月5日
出版者・発行元：一般社団法人日本歯科理工学会
ISSN：0286-5858
ハーモニックバイオマテリアル-界面制御型生体調和材料創製の可能性-MOCVD法により合成したCaTiO3膜の擬似体液中におけるHAp形成

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　138th　2006年

ISSN：1342-5730
ハンクス溶液中におけるCVD CaTiO3膜へのHAp生成

塗溶, 佐藤充孝, 後藤孝, 上田恭介, 成島尚之

日本セラミックス協会年会・秋季シンポジウム講演予稿集　2006　(0)　591-591　2006年
出版者・発行元：公益社団法人日本セラミックス協会

詳細を見る詳細を閉じる

縦型コールドウォール式ＣＶＤ装置を用い、Ca(dpm)2およびTi(OiPr)2(dpm)2によりCaTiO3膜を作製した。基板温度が973、1073 Kでは原料モル比が約1のとき、CaTiO3単一相が得られたが、873 KではCaTiO3とCaOの混合相が得られた。膜の微細組織波、基板温度の上昇に伴いCaTiO3膜の断面組織は緻密構造から柱状晶へと変化した。成膜速度は基板温度の上昇および反応室内圧力の減少とともに増大し、基板温度1073 K、反応室内圧力0.4 kPaでは最大であった。ハンクス溶液中におけるHApの生成を調べた。
特集「QOL向上のための材料技術」

新家光雄, 塙隆夫, 千葉晶彦, 成島尚之, 福井壽男, 岡崎義光, 池田勝彦

日本金属学会誌　70　(4)　259-259　2006年
生体材料としてのチタンおよびチタン合金

成島尚之

軽金属　55　(11)　561-565　2005年11月

DOI： 10.2464/jilm.55.561 　
チタンイオンがマクロファージ様細胞RAW264の細胞生存率に及ぼす影響評価(毒性, 平成17年度秋期 (長崎) 第46回日本歯科理工学会学術講演会)

平雅之, 佐々木かおり, 斉藤設雄, 根津尚史, 荒木吉馬, 成島尚之

歯科材料・器械　24　(5)　349-349　2005年9月5日
出版者・発行元：一般社団法人日本歯科理工学会
ISSN：0286-5858
Special Issue on Medical, Healthcare, Sport and Leisure Materials - Preface

M Niinomi, T Hanawa, Y Okazaki, M Ikeda, A Chiba, T Narushima, H Fukui

MATERIALS TRANSACTIONS　46　(7)　1514-1514　2005年7月
出版者・発行元：JAPAN INST METALS
ISSN：1345-9678

eISSN：1347-5320
生体用金属材料: チタン、チタン合金

成島尚之

バイオマテリアル　23　(2)　86-95　2005年4月
Japanese research and development on metallic biomedical, dental, and healthcare materials

M Niinomi, T Hanawa, T Narushima

JOM　57　(4)　18-24　2005年4月
出版者・発行元：SPRINGER
DOI： 10.1007/s11837-005-0076-3 　

ISSN：1047-4838

eISSN：1543-1851

詳細を見る詳細を閉じる

There is considerable demand for metallic materials for use in medical and dental devices. Metals and alloys are widely used as biomedical materials and are indispensable in the medical field. In dentistry, metal is used for restorations, orthodontic wires, and dental implants. This article describes R&D on metallic biomaterials primarily conducted by the members of the Japan Institute of Metals.
鉄鋼スラグ及び結晶性Al_2O_3を原料としたゼオライトAのアルカリ水熱合成

菅野善之, 木浪常利, 村上太一, 井口泰孝, 大内千秋, 成島尚之

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　18　(1)　205-205　2005年3月1日

ISSN：0914-6628
極微量のイットリウム添加α+β型チタン合金のβ粒成長に及ぼす加熱温度・時間の影響

堀田智史, 鈴木寛征, 村上太一, 井口泰孝, 大内千秋, 成島尚之

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　18　(3)　690-690　2005年3月1日

ISSN：0914-6628
チタン合金のβ粒微細化及び粒成長挙動に及ぼすY_2O_3分散粒子の影響

堀田智史, 村上太一, 成島尚之, 井口泰孝, 大内千秋

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　18　(3)　P33　2005年3月1日

ISSN：0914-6628
Preface of Special Issue on Medical Healthcare, Sport and Lesure Materials

M. Niinomi, T. Hanawa, Y. Okazaki, M. Ikeda, A. Chiba, T. Narushima, H. Fukui

Mat. Trans.　46　(7)　0　2005年
超微細組織を有する生体用新α+β型チタン合金の熱処理特性

平野貴大, 成島尚之, 井口泰孝, 大内千秋

大会講演概要　106　181-182　2004年5月18日
連続鋳造による9%Ni鋼のミクロ偏析に及ぼすオーステナイトでの動的再結晶の影響

堀田智史, 成島尚之, 井口泰孝, 大内千秋

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　17　(1)　159-159　2004年3月1日

ISSN：0914-6628
鉄鋼スラグを原料としたぜオライト類のアルカリ水熱合成

菅野善之, 木浪常利, 成島尚之, 井口泰孝, 大内千秋

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　17　(1)　89-89　2004年3月1日

ISSN：0914-6628
TiB及びY_2O_3分散粒子による粉末冶金チタン合金のβ粒微細化

山本直樹, 野村卓哉, 佐原亮二, 成島尚之, 井口泰孝, 大内千秋

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　16　(6)　1482-1482　2003年9月1日

ISSN：0914-6628
鋳造低合金鋼での動的再結晶後のγ粒成長挙動に及ぼす微量元素の影響

藤田昇輝, 成島尚之, 井口泰孝, 大内千秋

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　15　(6)　1152-1152　2002年9月1日

ISSN：0914-6628
動的再結晶による鋼の凝固オーステナイト粒の微細化及び粒成長挙動

藤田昇輝, 成島尚之, 井口泰孝, 大内千秋

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　15　(3)　615-615　2002年3月1日

ISSN：0914-6628
析出粒子及び動的再結晶による凝固オーステナイト粒径の微細化

大内千秋, 藤田昇輝, 成島尚之, 井口康孝

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　14　(6)　1151-1154　2001年9月1日

ISSN：0914-6628
超高純度精製技術に基づいた機能的電気刺激用生体埋込みステンレス鋼製電極の開発

井口泰孝, 成島尚之, 星宮望, 半田康延

ふぇらむ　4　(11)　737-740　1999年11月
ライム系物質の水和反応

泉千尋, 佐久間実, 成島尚之, 井口泰孝

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　12　(4)　826-826　1999年9月1日

ISSN：0914-6628
製鋼スラグの水和機構解明

泉千尋, 成島尚之, 井口泰孝

材料とプロセス : 日本鉄鋼協会講演論文集 = Current advances in materials and processes : report of the ISIJ meeting　11　(4)　775-775　1998年9月1日

ISSN：0914-6628
<記事>(4) 溶融シリコン中の不純物元素の物理化学的挙動(主題 : 素材・材料プロセスに係わる物性と評価)(素材工学研究所第 6 回研究懇談会)(素材工学研究会記事)

井口泰孝, 成島尚之, 東北大学大学院工学研究科, 東北大学大学院工学研究科

東北大学素材工学研究所彙報 = Bulletin of the Institute for Advanced Materials Processing, Tohoku University　53　(1)　138-139　1998年3月27日

ISSN：0919-4827
High-temperature oxidation of silicon carbide and silicon nitride

T Narushima, T Goto, T Hirai, Y Iguchi

MATERIALS TRANSACTIONS JIM　38　(10)　821-835　1997年10月
出版者・発行元：JAPAN INST METALS
DOI： 10.2320/matertrans1989.38.821 　

ISSN：0916-1821

詳細を見る詳細を閉じる

Oxidation behavior of silicon-based ceramics such as SiC and Si3N4 at high temperatures is important for their practical applications to structural or electronic materials. In the present paper two kinds of oxidation (passive and active) and active-to-passive transition of silicon-based ceramics were discussed thermodynamically, and the rate constants of passive/active oxidation and active-to-passive transition oxygen potentials for SiC and Si3N4 were reviewed. Passive and active oxidation behavior depended on the microstructure of oxide films and SiO gas pressure on silicon-based ceramics, respectively. Wagner model, volatility diagram and solgasmix-based calculation were used to estimate the active-to-passive transition.
東北大学工学部金属物理化学講座・研究紹介

井口泰孝, 成島尚之, 渡辺雅俊

資源・素材　1996　(1)　104-104　1996年10月21日

ISSN：0919-7915
太陽電池用シリコン製造プロセスにおける軽元素不純物の挙動に関する熱力学的研究

井口泰孝, 成島尚之, 簗場康司

資源・素材　1996　(6)　12-12　1996年10月1日

ISSN：0919-7915
口腔内児童骨炎長期の開発：ビーグル犬下顎骨への適用

勝部朝之, 成島尚之, 中野貴由, 馬越佑吉, 佐々木具文, 伊藤秀美, 古屋泰文, 川村仁

日本実験力学学会論文集　(6月2日)　58-61　1994年

︎全件表示 ︎最初の5件までを表示

書籍等出版物 20

チタンの基礎と応用

新家, 光雄, 池田, 勝彦, 成島, 尚之, 中野, 貴由, 細田, 秀樹

内田老鶴圃　2023年3月

ISBN: 9784753651122
製品利用に向けたバイオマテリアル開発の基本事項と注意点―材料の特徴・材料劣化・表面解析・安全性試験・ニーズ収集―

上田恭介, 成島尚之

情報機構　2022年6月

ISBN: 9784865022360
Phosphate and Borate Bioactive Glasses

K. Ueda, T. Narushima

Royal Society of Chemistry　2022年
チタンの準安定相・析出相研究部会報告書

成島尚之, 上田恭介, 廣瀬祐介

軽金属学会　2020年10月
Metals for biomedical devices, Second Edition

NARUSHIMA Takayuki

Woodhead Publishing　2019年8月
有機/無機材料の表面処理・改質による生体適合性付与

成島尚之

シーエムシー出版　2019年1月
バイオマテリアル：その基礎と先端研究への展開

成島尚之

東京化学同人　2016年2月20日
歯科再生・修復医療と材料

成島尚之, 上田恭介, 上田隆統志, 佐渡翔太

CMC出版　2015年8月25日
Advances in Metallic Biomaterials: Processing and Applications

M. Hirohashi, K. Ueda, T. Wada, T. Narushima, H. Kato

Springer　2015年6月27日

ISBN: 9783662468418
Advances in Metallic Biomaterials: Tissues, Materials and Biological Reactions

T. Narushima, K. Ueda, Alfirano

Springer　2015年6月27日

ISBN: 9783662468357
バイオマテリアル研究の最前線

成島尚之, 中野貴由

日本金属学会　2014年10月31日
未来型人工関節を目指して

成島尚之

日本医学館　2013年7月1日
Technological Advancements in Biomedicine for Healthcare Applications

T. Narushima, K. Ueda

IGI Global　2012年9月30日
Biological and Biomedical Coatings Handbook: Processing and Characterization (Advances in Materials Science and Engineering)

T. Goto, T. Narushima, K. Ueda

CRC Press　2011年4月
バイオマテリアルの基礎

成島尚之

日本医学館　2010年11月25日
Metals for biomedical devices

Takayuki Narushima

Woodhead Publishing Limited　2010年4月
金属材料の加工と組織

成島尚之

共立出版　2010年3月25日
医療用金属材料概論

成島尚之

（社）日本金属学会　2010年3月
チタンの基礎・加工と最新応用技術

成島尚之

シーエムシー出版　2009年8月
実験材料科学ニューマテリアル開発への基礎

内田老鶴圃, 東北大学工学部マテリアル, 開発系学生実験委員会, 編

1996年9月15日

︎全件表示 ︎最初の5件までを表示

講演・口頭発表等 105

生体用金属材料の表面・組織制御招待有り

成島尚之

日本鉄鋼協会東北支部湯川記念講演会　2023年12月3日
日本におけるチタン研究開発の最新動向

成島尚之

第3回日本チタン学会講演大会（2023年度）　2023年11月2日
Advancements of Ti research and development in Japan 招待有り

T. Narushima

2023 Fall Conference of the Korean Institute of Metals and Materials　2023年10月26日
Recent Activities of Titanium Research and Development in Japan 招待有り

T. Narushima

Titanium Technology Class　2023年8月24日
Recent Research and Development Activities on Titanium in Japan 招待有り

T. Narushima, T. Hirose

The 15th World Conference of Titanium (Ti-2023)　2023年6月12日
TiO2膜の光触媒活性を利用したチタン表面の抗菌機能化招待有り

成島尚之

日本金属学会2022秋季（第171回）講演大会　2022年9月21日
チタンの表面処理による抗菌機能化招待有り

成島尚之

2021年度東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会　2021年9月29日
高温酸化反応から見るチタン・チタン合金の熱力学招待有り

成島尚之

日本チタン学会;日本チタン協会産学連携委員会共同主催行事;年度第;回WEB教育講演;チタンの基礎;応用に関する教育講座　2021年6月18日
プラズマを用いたチタン融体からの酸素除去招待有り

成島尚之

第8回「チタン研究者･技術者研究交流会」　2021年3月4日
金属系バイオマテリアルの表面・組織制御

成島尚之

東北大学材料科学ウェビナー　2020年9月7日
材料工学における熱力学の役割招待有り

成島尚之

学際;国際的高度人材育成ライフイノベーションマテリアル創製共同研究プロジェクト第;回生体医療;福祉材料分野研究会　2020年1月29日
日本におけるチタン研究の動向招待有り

成島尚之

東邦チタニウム講演会　2020年1月22日
金属チタン研究の最先端招待有り

成島尚之

日本機械学会2019年度年次大会特別企画「チタンの研究と実用の最前線」　2019年9月9日
Preparation of bioceramic coatings on Ti and its alloys by dry processes and their antibacterial activity 国際会議招待有り

成島尚之

the 10th Pacific Rim International Conference on Advance Materials and Processing (PRICM-10)　2019年8月21日
Recent Activities of Titanium Research and Development in Japan 国際会議招待有り

T. Narushima, Y. Sugizaki

The 14th World Conference of Titanium (Ti-2019)　2019年6月11日
日本チタン研究の最先端

成島尚之

一般社団法人日本チタン協会, 2019年度通常総会記念講演会　2019年5月28日
水素プラズマを利用したチタン融体からの酸素除去の可能性

成島尚之

本金属学会チタン製造プロセスと材料機能研究会第5回講演会　2019年1月25日
Formation and Antibacterial Activity of TiO2 Layers on Ti-Au Alloys 国際会議招待有り

Takayuki Narushima, Kyosuke Ueda, Takatoshi Ueda, Naoki Sato

15th International Symposium on Functionally Graded Materials　2018年8月7日
Antibacterial activity of TiO2 layers formed on Ti-Au alloys by thermal oxidation 国際会議招待有り

T. Narushima, T. Ueda, N. Sato, K. Ueda, K. Ito, K. Ogasawara, H. Kanetaka

Finland-Japan Workshop: The next generation medical engineering in biomaterials, Joint with 3rd Bone and Biomaterials Workshop　2018年6月20日
Tiの高温酸化に及ぼすSiの影響に関する実験的・計算材料学的研究

成島尚之, 上田恭介, 鈴木聡, 佐原亮二, Somesh Kr. Bhattacharya

本金属学会チタン製造プロセスと材料機能研究会第4回講演会　2018年1月26日
ドライプロセスによる金属系バイオマテリアル表面処理の現状と展望

成島尚之

日本金属学会2017秋期（第161回）講演大会　2017年9月6日
バイオマテリアルｰからだの中で活躍する材料ｰ

成島尚之

東北大学工学部・工学研究科技術一般研修　2017年8月1日
ステント用金属系バイオマテリアルの機械的特性

成島尚之

SMAシンポジウム2016　2016年11月11日
NiTi and Co-Cr alloys used in biomedical stents 国際会議

T. Narushima, Alfirano, K. Ueda

National Seminar of Metallurgy and Materials IX (SENAMM IX)　2016年10月11日
Formation and evaluation of TiO2 layers on Ti alloys prepared by thermal oxidation

成島尚之

4th AMED-CNPq project seminar and meeting　2016年9月5日
Surface modification of Ti using bio-ceramic coating 国際会議

Takayuki Narushima, Takatoshi Ueda, Shota Sado, Kyosuke Ueda

2nd Bone and Biomaterials Workshop Hotelli Inari, Inarintie 40, 99870 Inari, Finland　2016年8月7日
Biomaterials, Smart Materials and Structures 国際会議

Takayuki Narushima

The Ninth Pacific Rim International Conference on Advanced Materials and Processing (PRICM 9)　2016年8月1日
Precipitates and mechanical properties of metallic biomaterials 国際会議

Takayuki Narushim

Thermec’ 16, Intl’ Conf. on Processing & Manufacturing of Advanced Materials　2016年5月30日
ドライプロセスを用いたチタンの生体用表面改質

成島尚之

軽金属学会第130回春期大会　2016年5月28日
Fatigue properties of NiTi wires used in biomedical applications 国際会議

Takayuki Narushima

The 6th International Symposium for Interface Oral Health Science　2016年1月18日
レアメタル一次資源部門

成島尚之

東北大学レアメタル・グリーンイノベーション研究開発センター第一回フォーラム　2015年12月22日
生体材料としてのチタン

成島尚之

仙台青葉工業クラブ第42回講演会　2015年10月18日
金属系バイオマテリアルと軽元素との反応

成島尚之

東北大学金属材料研究所共同研究ワークショップ、日本バイオマテリアル学会東北地域講演会　2015年9月7日
Formation and evaluation of thermally-oxidized titania layer on Ti and Ti alloys 国際会議

Takayuki Narushima, Takatoshi Ueda, Shota Sado, Kyosuke Ueda

Ti-2015: The 13th World Conference on Titanium　2015年8月16日
金属系バイオマテリアルの表面・組織制御

成島尚之

第65回日本歯科理工学会学術講演会　2015年4月16日
生体用NiTiの晶析出物と疲労特性

成島尚之, 原健治, 上田恭介, 山下史祥, 石川浩司

東北大学金属材料研究所共同研究ワークショップ、日本バイオマテリアル学会東北地域講演会　2014年10月6日
二段階熱酸化プロセスを利用した生体用チタンの表面処理

成島尚之, 佐渡翔太, 近藤なつ美, 上田恭介

第181回腐食防食シンポジウム　2014年9月16日
Reaction between light elements and metallic biomaterials: thermal oxidation and precipitation 国際会議

T. Narushima

156th IBB Seminar, JST-CNPq Project　2014年9月16日
金属系バイオマテリアルの軽元素メタラジー

成島尚之

北海道大学工学研究院材料科学専攻第51回マテリアルセミナー　2014年5月27日
Photocatalytic evaluation of TiO2 layer formed on titanium by thermal oxidation 国際会議

T. Narushima, S. Sado, K. Ueda, M. Kawano, K. Ogasawara

Innovative Research for Biosis-Abiosis Intelligent Interface Symposium　2014年1月20日
Formation of anatase layer using two-step thermal oxidation and its evaluation 国際会議

T. Narushima, K. Ueda, S. Sado

5th International Symposium on Advanced Ceramics (ISAC-5)　2013年12月9日
Precipitates and properties of biomedical Co-Cr-W-Ni alloys 国際会議

T. Narushima, Y. Kurihara, K. Ueda

International Conference on Processing & Manufacturing of Advanced Materials (THERMEC’ 2013)　2013年12月2日
金属材料のセラミックスコーティング

成島尚之, 上田恭介

学振第176委員会（加工プロセスによる材料機能発現）第24回研究会　2013年11月1日
Surface treatments of titanium using thermal oxidation 国際会議

T. Narushima, K. Ueda, S. Sado

The Eighth Pacific Rim International Conference on Advanced Materials and Processing (PRICM-8)　2013年8月4日
チタン系融体の脱酸と析出物への影響

成島尚之, 上田恭介, 伊藤大介, 西脇成彦

日本金属学会機能性チタン合金研究会　2013年1月28日
ドライプロセスによるバイオセラミックス被覆

成島尚之

日本バイオマテリアル学会シンポジウム2012　2012年11月26日
Bioceramic Coating on Titanium Using Dry Process 国際会議

T. Narushima

The 5th International Symposium on Designing, Processing and Properties of Advanced Engineering Materials ISAEM-2012　2012年11月5日
Precipitates in biomedical Co-Cr-Mo alloys 国際会議

T. Narushima

Korea-Japan Joint Work Shop on Biomaterials　2012年9月25日
生体用Co-Cr-Mo合金における晶析出挙動

成島尚之

日本金属学会 2012年秋季（第151回）大会公募シンポジウム「体用Co-Cr合金研究の現状と将来展望」　2012年9月17日
熱酸化法によるチタン表面へのアナターゼ形成と評価

成島尚之

東北大学金属材料研究所共同研究ワークショップ、日本バイオマテリアル学会東北地域講演会　2012年9月3日
Precipitation in biomedical Co-Cr and NiTi alloys 国際会議

T. Narushima

The Japan-Finland Joint Workshop on Future Implant, Research Seminar in Oulu　2012年8月8日
Surface modification of titanium using dry process 国際会議

T. Narushima

The Japan-Finland Joint Workshop on Future Implant, Research Seminar in Helsinki　2012年8月6日
金属系生体材料における軽元素メタラジー

成島尚之

東北大学学際科学国際高等研究センター第48回インフォーマルセミナー　2012年2月24日
Precipitates in biomedical Co-Cr-Mo and NiTi alloys 国際会議

T. Narushima

Workshop on a foreign experts academic exchange project　2011年11月2日
Fabrication and Evaluation of Amorphous Calcium Phosphate Film on Titanium 国際会議

T. Narushima, K. Ueda, T. Goto, N. Nishiwaki, S. Yokota, H. Kawamura

Workshop on Materials Science in Tianjin University Day　2011年10月11日
金属系バイオマテリアル中の析出相

成島尚之

東北大学金属材料研究所共同研究ワークショップ、日本バイオマテリアル学会東北地域講演会　2011年9月29日
Deoxidation of NiTi alloys using metallic barium and their microstructures 国際会議

T. Narushima, D. Ito, K. Ueda

The 12th World Conference on Titanium　2011年6月20日
Precipitates in Metallic Biomaterials 国際会議

T. Narushima

The 4th International Symposium for Interface Oral Health Science　2011年3月7日
ドライプロセスを利用したチタン系材料の表面・バルク処理

成島尚之

日本鉄鋼協会・日本金属学会関西支部材料開発研究会平成２２年度第４回研究会　2011年1月20日
Surface Modification of Titanium for Biomedical Applications 国際会議

Takayuki Narushim

The 1st Joint Workshop on Advanced Materials Research & Application, Dalian University of Technology - Tohoku University　2010年11月3日
生体用Co-Cr-Mo合金中の析出物形成および溶解挙動

成島尚之, 峯田真悟, Alfirano, 難波茂信, 米田隆志, 上田恭介

東北大学金属材料研究所共同研究ワークショップ、日本バイオマテリアル学会東北地域講演会、金属系バイオマテリアルの力学的および生物学的生体機能性の付与－骨機能再建・再生マテリアルの創製に向けて－　2010年8月30日
Calcium Phosphate Coating on Titanium Using Dry Process 国際会議

Takayuki Narushima

The Seventh Pacific Rim International Conference on Advanced Materials and Processing (PRICM7)　2010年8月1日
Research and Development of Metallic Biomaterials in Japan 国際会議

Takayuki Narushima

Special Seminar in Research Center for Metallurgy　2010年7月16日
Research and Development of Metallic Biomaterials in Japan 国際会議

Takayuki Narushima

4th National Seminar of Metallurgy and Material　2010年7月14日
Surface treatment of titanium by gas processes 国際会議

Takayuki Narushima

International Cooperation between KITECH and Tohoku University　2010年2月25日
金属系生体材料の高機能化

成島尚之

MAST21 第14回フォーラム　2009年11月27日
ガス法によるチタン材料の表面硬化処理

成島尚之

日本金属学会機能性チタン合金研究会第２回講演会　2009年11月20日
Surface modification of titanium by dry process for biomedical applications 国際会議

T. Narushima, K. Ueda, T. Goto

the 9th International Symposium on Biomaterials　2009年10月29日
ユビキタス時代に向けたチタンの元素戦略と新しい用途展開『新しい用途展開(Ⅳ) 生体・医療用途』

成島尚之

第61回白石記念講座　2009年10月9日
骨/リン酸カルシウムコーティング膜/チタンインプラント界面の力学特性

成島尚之, 上田恭介, 後藤孝

日本金属学会 2009年秋季（第145回）大会公募シンポジウム「力学的生体適合性」　2009年9月15日
Surface modification of titanium by pack cementation process for biomedical applications 国際会議

Takayuki NARUSHIMA

The third International Conference on Processing, Manufacturing of Advanced Materials (ICAM-2009)　2009年7月8日
Fabrication and Evaluation of Calcium Phosphate Films Coated on Blast-treated Ti-6Al-4V Substrate 国際会議

Takayuki NARUSHIMA

International Conference on Materials for Advanced Technologies (ICMAT 2009)　2009年6月28日
金属系生体材料製造プロセスにおける軽元素の挙動

成島尚之

第126回特殊鋼部会大会　2009年6月4日
Calcium phosphate coating on titanium by RF magnetron sputtering 国際会議

KIM-JIM Symposium　2009年3月29日
酸素を利用したチタンの表面・組織制御

成島尚之

第34回材質制御研究会―歯科材料を中心した生体材料開発の最前線―　2008年12月26日
In vivo and in vitro evaluation of amorphous calcium phosphate films coated on titanium implants by RF magnetron sputtering 国際会議

T. Narushima

4th International Symposium on Designing,Processing and Properties of Advanced Engineering Materials (ISAEM-2008)　2008年11月18日
Calcium phosphate formation on NaOH-treated titanium in simulated body fluids 国際会議

Takayuki Narushima, Shuntaro Watanabe, Kenichi Kato, Kyosuke Ueda

the 2008 Fall Annual Meeting of the KIM, 2008 Fall Conference　2008年10月23日
Amorphous Calcium Phosphate Thin Film Coated on Titanium Implant by RF Magnetron Sputtering 国際会議

T. Narushima

2nd PNU – IMR Joint Workshop on Advanced and Bio Materials　2008年6月6日
リン酸カルシウムコーティングを施したチタン材料の生体内外評価

成島尚之

社団法人軽金属学会第１１３回大会　2007年11月10日
In vivo and In vitro Evaluation of Calcium Phosphate Coating Films on Blast-treated Titanium Substrate 国際会議

T. Narushima, K.Ueda, T.Goto, H.Kawamura, T.Katsube

Symposium on the Nano Particles and Highly-functional Interface Science　2007年8月9日
Fatigue Properties of Titanium Wires for Medical Applications 国際会議

K.Ueda, T.Kinami, H.Kimura, C.Ouchi, Y.Iguchi

The 11th World Conference on Titanium　2007年6月3日
Calcium Phosphate Coating on Titanium by RF Magnetron Sputtering for Medical Applications 国際会議

T. Narushima

The joint symposium on advanced materials between Pusan nationals university and Tohoku university　2007年5月7日
チタン上に作製したリン酸カルシウムスパッタリング膜の生体内外評価

成島尚之

東北大学金属材料研究所共同研究ワークショップ　2006年12月13日
Evaluation of Calcium Phosphate Coating Films on Titanium Fabricated Using RF Magnetron Sputtering 国際会議

T. Narushima, K. Ueda, T. Goto, M. Taira, T. Katsube

the 4th Korea-China Symposium on Biomaterials and Nano-bio Technology　2006年10月19日
Evaluation of RF-magnetron-sputtered calcium phosphate films on titanium for implant applications 国際会議

T. Narushima

The 2nd. Korean-Japan joint workshop on biomedical materials　2006年10月9日
Calcium Phosphate Coating on Titanium by RF Magnetron Sputtering for Medical Applications 国際会議

T. Narushima

Thermec’2006, International Conference on Processing & Manufacturing of Advanced Materials　2006年7月4日
Calcium Phosphate Coating on Titanium by RF Magnetron Sputtering for Medical Applications 国際会議

T. Narushima

Non-ferrous Metal Seminar between China and Japan　2006年3月15日
Calcium Phosphate Films Coated on Titanium by RF Magnetron Sputtering 国際会議

T. Narushima

Korea-Japan Symposium on Nano-Bio Technology –Interdisciplinary Science of Nanomaterials for Asia Core Program-　2006年2月14日
リン酸カルシウムコーティングによるチタン材料の生体機能化

成島尚之

学術討論会若手生体材料研究者が目指す金属とセラミックス、高分子とのインテグレート生体機能材料　2006年1月16日
Characterization of Calcium Phosphate Films Prepared by RF Magnetron Sputtering 国際会議

T. Narushima

The 1st Korean-Japan joint workshop on biomedical materials　2005年12月12日
Characterization of Calcium Phosphate Films Prepared by RF Magnetron Sputtering 国際会議

T. Narushima

2005 MRS Fall Meeting　2005年11月28日
東北大学先進医工学研究機構における生体材料に関する研究

成島尚之

東北大学素材・材料開発研究会　2005年6月10日
Evaluation of Fatigue Property of Titanium Wires by Rotating-bending Testing in 1mass% Lactic Acid Solution 国際会議

T. Narushima, K.Ueda, M.Yamashita, T.Murakami, C.Ouchi, Y.Iguchi

The 9th Annual Conference of the International Functional Electrical Stimulation Society　2004年9月5日
Bio-materials Researches at Tohoku University 国際会議

T. Narushima, T.Katsube, C.Ouchi, Y.Iguchi

Symposium on Materials Science in Japan, China, and Korea　2004年6月15日
新しい生体用チタン合金の研究開発動向とその課題

成島尚之

第17回歯科チタン学会　2004年2月14日
Nitridation of Titanium-Tin Alloys during Heating in Air 国際会議

T. Narushima, K.Suzuki, S.Kimura, Y.Iguchi, C.Ouchi

The 10th World Conference on Titanium　2003年7月13日
Refinement of β Grain Size Due to TiB or Y2O3 Precipitates in Titanium Alloy 国際会議

T. Narushima, K.Suzuki, S.Kimura, Y.Iguchi, C.Ouchi

The 10th World Conference on Titanium　2003年7月13日
Calorimetric Study on Hydration of CaO-based Oxides 国際会議

T. Narushima, Y.Iguchi, C.Izumi

Kleppa Symposium, 2000 Annual Spring Meeting, TMS　2000年3月
Oxygen Distribution between Molten B2O3 Flux and Indium or Gallium 国際会議

T. Narushima, Y.Iguchi, M.Kinoshita, Y.Hino

The 5th International Conference on Molten Slags, Fluxes and Salts　1997年1月
Determination of Free Lime Contents in Slags by Solution Calorimetry 国際会議

T. Narushima, Y.Muraki, Y.Iguchi

ICS'96　1996年4月
In situ Observation of Oxide Films Formed during Thermal Oxidation of SiC-B4C Composite 国際会議

T. Narushima, M.Maruyama, H.Arashi, T.Goto, T.Hirai, Y.Iguchi

European Ceramic Society 4th Conference　1995年9月
High-Temperature Active Oxidation of CVD-Si3N4 in N2-O2 Atmosphere 国際会議

T. Narushima

Advanced Materials '93　1993年10月
High-Temperature Active Oxidation of CVD-Si3N4 in Ar-O2 Atmosphere 国際会議

T. Narushima, Y.Iguchi, T.Goto, T.Hirai, Y.Yokoyama

SSI-8　1991年10月
High-Temperature Oxidation of CVD-SiC in CO-CO2 Atmosphere 国際会議

T. Narushima, T.Goto, Y.Iguchi, T.Hirai

High Temperature Corrosion of Advanced Materials and Protective Coatings　1990年11月
Active to Passive Transition in the Oxidation of CVD-SiC 国際会議

T. Narushima, T.Goto, T.Hirai

MRS International Meeting on Advanced Materials　1988年6月

︎全件表示 ︎最初の5件までを表示

産業財産権 13

NiTi系合金材料、NiTi系合金の製造方法、NiTi系合金材料からなる線材または管材、およびその製造方法

山下史祥、喜瀬純男、藤井美里、石川浩司、成島尚之、上田恭介、加藤卓

産業財産権の種類: 特許権

権利者: 国立大学法人東北大学、株式会社古河テクノマテリアル
チタン素材の脱酸方法

松若大介, 成島尚之, 上田恭介

産業財産権の種類: 特許権

権利者: 株式会社神戸製鋼所
METHOD FOR PURIFYING TITANIUM MATERIAL

MATSUWAKA Daisuke, NARUSHIMA Takayuki, UEDA Kyosuke

産業財産権の種類: 特許権

権利者: KABUSHIKI KAISHA KOBE SEIKO SHO (KOBE STEEL, LTD.)
光触媒機能性部材およびその製造方法

成島尚之, 上田恭介, 上田隆統志, 佐渡翔太, 小笠原康悦, 伊藤甲雄, 金高弘恭

産業財産権の種類: 特許権

権利者: 国立大学法人東北大学
耐熱Ti合金および耐熱Ti合金材

成島尚之, 上田恭介, 前田幸大, 鈴木聡

産業財産権の種類: 特許権

権利者: 国立大学法人東北大学
Ti-Si系合金の脱酸方法

松若大介, 成島尚之, 上田恭介, 渡辺将仁

産業財産権の種類: 特許権
NiTi系超弾性合金材料または形状記憶合金材料及びこれを用いた線材または管材

成島尚之, 上田恭介, 原健治, 山下史祥, 石川浩司

産業財産権の種類: 特許権
チタン合金とアルミニウム材料の接合方法

村上太一, 大内千秋, 成島尚之, 井口泰孝

産業財産権の種類: 特許権
自動骨延長用装置及びその使用方法

成島尚之, 勝部朝之, 川村仁

産業財産権の種類: 特許権
酸化物の還元反応を利用した発泡金属製造法

村上太一, 成島尚之, 井口泰孝, 大内千秋

産業財産権の種類: 特許権
産業副生成物からのマグネシウム及びカルシウム除去回収とA型ゼオライト製造方法

村上太一, 成島尚之, 井口泰孝, 大内千秋, 菅野善之

産業財産権の種類: 特許権
ゼオライトの製造方法

成島尚之, 井口泰孝, 大内千秋, 木浪常利, 菅野善之

産業財産権の種類: 特許権
Ca-βアルミナとジルコニア固体電解質よりなる結合型ガスセンサー

鹿野弘, 会田広治, 井口泰孝, 成島尚之, 中澤壮三

産業財産権の種類: 特許権

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共同研究・競争的資金等の研究課題 32

スパイクタンパク質に着目したコロナウイルスを不活性化させる材料表面設計

成島尚之, 佐原亮二, 小笠原康悦, 上田恭介, 金高弘恭, 伊藤甲雄

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (A)

研究機関：Tohoku University

2021年4月5日～ 2025年3月31日

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令和3年度は以下の3項目に関して研究を遂行した。 (a)計算材料学的手法によるTiO2のバンドギャップの精密評価方法の確立：密度汎関数法を用いた平面波-擬ポテンシャル法電子状態計算プログラムVASPにより炭素・窒素を添加したアナターゼ型TiO2の熱力学的安定性を評価した。TiO2中の炭素・窒素の安定な存在状態（化学状態）は雰囲気の酸素ポテンシャルに依存することを明らかにした。全電子混合基底法を基礎とした第一原理計算プログラムTOMBOにより、炭素・窒素の安定な存在状態におけるアナターゼ型TiO2のバンドギャップを評価した。（イ）10^-20 atm程度の酸素分圧下で安定な炭素・窒素がTiO2のバンドギャップエネルギーの低下に寄与する、（ロ）炭素および窒素の共添加がTiO2のバンドギャップエネルギーの低下に有効、であることが分かった。 (b)二段階熱酸化法による窒素添加TiO2膜の抗菌特性評価：二段階熱酸化法によりチタン基板上に作製した炭素・窒素添加TiO2膜の可視光照射下における抗菌性を評価した。菌種としては大腸菌を用いた。15分という短時間可視光照射でも抗菌活性値1（90%の菌が死滅）が得られた。ECR（電子スピン共鳴）法により可視光照射下でのラジカル発生を確認した。抗菌能評価結果を抗ウイルス特性発現のスクリーニングとして用いる。 (c)スパイクタンパク質を有する融合タンパク質定量方法の確立：ELISA（酵素結合免疫吸着測定）法を用いることで融合タンパク質の定量分析手法を確立した。一次抗体の種類や溶液の適切な選択、融合タンパク質の回収方法の最適化を図ることが必要であった。確立した手法を応用することでTiO2膜の光触媒活性に伴うスパイクタンパク質不活化評価実験を行う体制が構築された。
表面化学反応機構の理論的解明による耐熱材料の高精度制御

佐原亮二, 成島尚之, 上田恭介

2021年4月1日～ 2024年3月31日
元素徐放型高密着バイオアクティブコーティングによるインプラントへの機能付与

上田恭介, 成島尚之, 李誠鎬, 小笠原康悦, 金高弘恭

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2020年4月1日～ 2024年3月31日

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チタン製歯科インプラントの骨との迅速・強固な結合およびインプラント周囲炎予防を目的として、チタンへの生体内溶解性ガラス組成の検討およびそのコーティングプロセスを検討した。コーティング膜組成として、骨適合性と生体内溶解性を有するSi-Ca-P-O系生体活性ガラスをベースとし、抗菌性元素(X)、骨形成能向上元素(Y)および溶解性制御元素(Z)を添加したSi-Ca-P-O-X-Y-Z系ガラスに着目した。コーティング膜組成決定のために、ゾルゲル法にて元素添加生体活性ガラス粉末を合成した。本生体活性ガラス系において、ガラス中に固溶する元素、リン酸カルシウム系結晶相の形成を促進する元素を定量的に明らかした。擬似体液中への溶解性を評価したところ、抗菌性元素の徐放が確認され、抗菌性の発現が期待できる。コーティングプロセスとしては、ゾルゲル・ディップコーティング法を用いた。本プロセスは安価で簡便にガラスやセラミックスコーティング膜を作製できるものの、基板との密着力が低いことが知られている。そこで、基板であるチタンを活性化処理し、中間層を作製することで、基板と化学的に結合した生体活性ガラスコーティング膜作製を試みた。ゾル組成やディップコーティング条件を制御することで、膜厚数マイクロメートルの均一なコーティング膜作製条件を見出すことができた。今後は、粉末合成により明らかにした組成の生体活性ガラスをチタン基板上にコーティングし、基板との密着力、擬似体液における溶解性、抗菌性、細胞培養試験による骨適合性を評価する。
骨形成能と抗菌能を両立させた光機能性チタン表面の創製とインプラントへの応用

成島尚之, 佐原亮二, 小笠原康悦, 上田恭介, 金高弘恭

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2018年4月1日～ 2022年3月31日

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歯科インプラントへの応用を念頭に、骨形成能と抗菌能を両立させたチタン表面の作製に成功した。熱酸化を基礎とした独自プロセスによりチタン表面に作製したAu含有TiO2膜は可視光照射下で大腸菌に対して抗菌性を発現した。本研究で得られたAu含有TiO2膜の光機能はインプラント自身が骨組織との再密着による「治癒」を担い、かつ患者自身による「予防」も可能にするという「セルフメインテナンス機能」を具現化するための成果である。これらの成果はTiO2膜とチタン基材の優れた密着力と併せて、インプラント応用ばかりでなく新型コロナウイルス(SARS-CoV-2)の接触感染予防への展開も期待できる。
水素プラズマアークを利用したチタン融体からの酸素除去：300ppmへの挑戦

成島尚之, 上田恭介

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Research (Exploratory)

研究機関：Tohoku University

2018年6月29日～ 2020年3月31日

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従来困難とされてきたチタン融体からの酸素除去プロセスを確立した。そのプロセスは水素プラズマアーク溶解（第一段階目溶解）とアルゴンプラズマアーク溶解（第二段階目溶解）から構成される。水素分圧、溶解時間、ガス流量やプラズマ電流などを最適化することで、チタン融体中において0.127mass%（1270 mass ppm）から0.034mass%（340 mass ppm）への酸素除去を達成した。プラズマ中の活性な原子状水素の高い水素ポテンシャルに応じてチタン融体中に導入された溶存水素が第二段階目溶解で脱酸剤として機能していることが熱力学的考察から示唆された。本研究成果を基礎に国際特許出願を行った。
非晶質リン酸カルシウム薄膜を担体とした骨形成タンパク質の徐放性制御

上田恭介, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2017年4月1日～ 2020年3月31日

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Ti製硬組織代替デバイスの骨との迅速かつ強固な結合および抗菌性の両立を目指し、非晶質リン酸カルシウム(ACP)の生体内溶解性に着目した表面処理方法を構築した。RFマグネトロンスパッタリング法により作製した膜厚0.5μmのACPコーティング膜に骨形成タンパク質(BMP)を担持させることができた。ACPコーティングの溶解に伴うBMPの徐放を確認できた。ターゲット組成を変化させることで、AgおよびTaを供添加したACPコーティング膜を作製できた。Ta添加による溶解性の抑制とAgイオンの放出による抗菌性発現を達成できた。
生体吸収性非晶質リン酸カルシウム薄膜を担体とした薬剤徐放型インプラントの創製

上田恭介, 金髙弘恭, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Exploratory Research

研究機関：Tohoku University

2015年4月1日～ 2017年3月31日

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非晶質リン酸カルシウム(ACP)の生体吸収性に着目し、ACP薄膜の徐放に伴う骨形成タンパク質(BMP-2)の放出制御を試みた。ACP薄膜をBMP-2溶液に浸漬させることでBMP-2を担持させた。PBS(-)にて希釈したBMP-2溶液を用いた場合、ACP薄膜からのBMP-2放出は12 hまで続き、徐放させることができた。ヘパリンを共添加した溶液にて担持させた場合は、BMP-2は1 h以内に放出していた。以上の結果から、ACP薄膜はBMP-2の担体として有効であることが示唆された。
低温プラズマジェット照射による新しいインプラントリカバリーシステムの構築

金高弘恭, 佐々木啓一, 成島尚之, 金子俊郎, 川下将一, 工藤忠明

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2013年4月1日～ 2016年3月31日

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歯科用インプラントは予知性の高い治療法として広く普及しているが、一方でインプラント周囲炎などの課題も残されている。そこで本研究では、問題の生じたインプラントを撤去することなく口腔内で機能的かつ形態的な回復を獲得する方法として、①強力な殺菌、不良組織除去、②インプラント表面再活性化処理、③組織再生を３本柱とする全く新しい手法による口腔内でのリカバリーシステム構築を目的とした。研究成果として、低温プラズマジェットの最新技術を応用し、生体活性を失ったインプラントに対して、口腔内で安全に殺菌および表面再活性化処理を行うことで、良好な組織再生を促進するリカバリーシステムの基盤の構築を行った。
セラミックス界面層構築による金属材料の生体機能化とその評価

成島尚之, 春日敏宏, 小笠原康悦, 上田恭介

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (A)

研究機関：Tohoku University

2013年4月1日～ 2016年3月31日

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Ti製インプラントの生体機能化を目的に、非晶質リン酸カルシウム（ACP）およびTiO2といったセラミックスコーティング膜の作製と抗菌性評価を行った。スパッタリング法により作製したAg固溶ACP膜はACPの生体吸収に伴うAgイオン徐放により、継続的な抗菌性を発現した。熱酸化法により作製した元素添加TiO2膜は光照射下において有機物分解能および抗菌性を発現した。特に、Ti-4.2at%Au合金表面に作製したAu添加TiO2膜では可視光応答型光触媒活性が確認できた。コーティングプロセスの最適化により優れた骨形成能と抗菌性の両方を有した界面層の構築が可能であることを示した。
ＮｉＴｉの表層域ポーラス化とＮｉイオン溶出抑制

上田恭介, 成島尚之, 加藤秀実

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Exploratory Research

研究機関：Tohoku University

2012年4月1日～ 2014年3月31日

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金属浴浸漬法をNiTi合金に適用することにより、表面からNiを除去したポーラス層を作製することができた。反応層のNi濃度は基板側から段階的に減少し、内側はTi2Ni相、表層はα-Ti相となった。これらの試料からの1mass%乳酸中への金属イオン溶出量は、Mg浴浸漬試料においては、ポーラス化による表面積の増大にも関わらずNiイオン溶出量は未処理試料と同程度であった。二段階熱酸化法によるアナターゼ皮膜形成によっても、Niイオン溶出量を抑制することができた。
骨表面における骨増量のための自家骨再生法

川村仁, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2011年4月1日～ 2014年3月31日

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我々は骨表面から骨膜を徐々に持ち上げ骨表面に新生骨を誘導する研究を進めている。本研究ではこの誘導した新生骨に、より適したデンタルインプラントシステムの開発を行った。RFマグネトロンスパッタリング法で吸収性非晶質リン酸カルシウムを薄くコーティングしたインプラントは早い段階で周囲骨からのdistance osteogenesisのみでなくコーティング薄膜表層からのinner osteogenesisを生じさせる可能性を示した。機械的固定力も速やかに高まった。結果として、吸収性非晶質リン酸カルシウムを薄膜でコーティングしたインプラントは骨反応を促進し速やかに機械的固定力高めることが示唆された。
生体吸収性リン酸カルシウム系コーティング膜を利用した骨適合界面の創製

成島尚之, 上田恭介, 川村仁, 春日敏宏, 平雅之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2010年～ 2012年

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スパッタリング法で工業用純チタン表面に作製した非晶質リン酸カルシウム膜の生体内外評価を行った。非晶質リン酸カルシウムコーティングを施したチタンインプラントを白色家兎大腿骨および脛骨に埋入したところ、インプラント安定指数(ISQ値)や骨接触率の有意な上昇が観察された。埋入2週後には既にコーティング膜は生体吸収されており、CaやP関連イオンの徐放が骨適合性向上の支配因子と考えられた。非晶質リン酸カルシウム膜へのNb添加は溶解性を低下させ、生体吸収性制御に有力であった。
骨形成能向上を目的としたパックセメンテーション法によるチタン系材料の表面改質

上田恭介, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2009年～ 2010年

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チタンの骨適合性向上を目的として、パックセメンテーション法、定温定圧法およびその複合により、チタン表面にリン酸カルシウム反応層を作製した。得られた反応層はハイドロキシアパタイト(HAp)相およびCa-P-O-Ti傾斜層であり、厚さは数μm程度であった。本法は、基板との優れた密着力を示し、細胞培養試験からも高いALP活性能を示したことから、新規表面処理方法として有効であることが示唆された。
骨形成能制御を目的としたチタン及びチタン合金のセラミックス化表面改質

成島尚之, 上田恭介, 勝部朝之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2007年～ 2009年

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チタンの骨形成能向上を目的として、表面に生体活性セラミックスを形成する表面改質プロセス開発と評価を行った。代表的な成果は以下の通りである。(1)RFマグネトロンスパッタリング法により作製した非晶質リン酸カルシウムコーティング膜はチタンの骨適合性を向上させると共に生体に吸収されることを明らかにした。(2)二段階熱酸化法という簡便で生産性の高いプロセスによりチタン上に骨適合性に優れたアナターゼ皮膜を作製することに成功した。
生体吸収性材料とチタン合金を用いた自家骨再生・修復デバイス開発-治験申請を目指す

成島尚之, 勝部朝之, 川村仁, 後藤孝, 井口泰孝, 大内千秋

2005年～ 2006年

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本年は、生体吸収性を有するリン酸カルシウムコーティング膜として、擬似体液中における迅速なアパタイト形成及びカルシウムイオン溶出が確認された非晶質リン酸カルシウム(ACP)に着目し、その生体内外評価を行うと共に、β型チタン合金の人工歯根としての可能性を検討した。 (1)ACP膜の生体外評価: ACPコーティング膜のチタン基板との密着力をアルミニウムスタッド引き抜き法により評価した。コーティングままでは、60MPa以上の密蒲力が得られたが、擬似体液中へ浸漬後の密着力は30MPaへと低下した。これに対し、ブラスト処理を施したチタン基板においては、擬似体液浸漬後においてもコーティングままと同等以上の密着力が得られた。インプラント用コーティング膜の密着力としては50MPa以上が必要とされているが、それを満足するものと評価できる。 (2)ACP膜の生体内評価: 前年にビーグル犬下顎骨に埋入したACPコーティングを施したチタンシリンダーと骨界面の骨接触率を評価した。その結果、8-12週埋入後において、ACPコーティング膜の存在が骨接触率を有意(P<0.05)に上昇させることを見出した。また、インプラント-骨界面における新生骨量に関しても、ACPコーティング材において有意(P<0.05)に大きいことがわかった。 (3)コーティング膜総合的評価: 生体内外評価によりRFマグネトロンスパッタリング法により作製した生体吸収性ACPコーティング膜はチタンの骨適合性を向上させることが明らかとなった。 (4)β型チタン合金の人工茜根への応用: Ti-6at%Mo-4at%Snを素材とした人工歯根のビーグル犬下顎骨への埋入実験を行い、骨接触率に関してCPチタン材と大きな差異のないことを確認した。
メタンガスを利用したチタン母材組織の超微細化を伴う新表面硬化処理法

成島尚之, 大内千秋, 村上太一, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：TOHOKU UNIVERSITY

2005年～ 2006年

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(1)メタンガス処理アルゴン-5%メタン処理後の表面最高硬さおよび硬化層深さは1198K、10.8ksの処理を施したTi-6Al-4V合金で850Hvおよび230μm、1073K、21.6ksの処理を施したTi-4.5Al-3V-2Fe-2Mo(SP-700)合金で880Hvおよび130μmであった。炭素の固溶に伴うチタン材料の顕著な表面硬化が観察された。しかし、アルゴン-5%メタン処理による吸水素は組織の微細化を達成するために十分な量ではなかった。 (2)メタン-水素混合ガスによる処理 CH_4:H_2=1:1雰囲気での吸水素処理を1023Kにおいて1.8ks行った。吸水素量は十分であったが、時効処理、脱水素処理を経ても、いずれのチタン合金においても組織は微細化されなかった。組織を詳細に観察すると、表層付近には微細な組織が観察される領域が存在した。表層付近は炭素の固溶により表面硬化と共に、β変態点が上昇していると考えられる。すなわち、各合金のβ変態点と処理温度の関係の把握が必要であることを示唆すると判断した。 (3)水素のみを用いた組織微細化条件の検討吸水素条件、1023K、1.8ks、時効処理523〜873K,28.8ks、脱水素処理973〜1173K,3.6ksにおいて、組織微細化を検討した。Ti-6Al-4Vにおいては、773Kにおける時効処理の後、脱水素処理を973Kから1173Kにおいて行うことで等軸化も含めた微細組織制御が可能であった。一方、SP-700合金の微細化は達成されず、針状のα相が形成された。この理由は、SP-700合金のβ変態点がTi-6Al-4Vよりも100Kほど低いために、吸水素処理と時効処理で十分なひずみが導入されなかったためと考えられた。今後、吸水素条件の詳細な検討が必要と思われる。
生体インプラント用金属およびセラミックス材料表面反応に及ぼす応力の影響

成島尚之, 大内千秋, 井口泰孝, 平雅之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：TOHOKU UNIVERSITY

2004年～ 2005年

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種々のインプラント用材料の摩耗特性とそれに伴う摩耗紛形成、イオン溶出、摩耗特性向上のためのガス法による表面処理および粉末と細胞との反応などを明らかにした。 (1)擬似体液中におけるインプラント用材料の摩耗挙動 1.摩耗試験における1%乳酸溶液中への金属イオン溶出量は、ハンクス溶液中と比較して大きな値を示した。 2.いずれの材料を用いた場合も、摺動距離および接触応力の増加に関わらずWear lossは一定の値を示した。一方、Elution rateは摺動距離の増加に伴い増加した。 3.C.P.チタンを用いた場合、他のチタン合金と比較してElution rateは高い値を示した。これは、生成した摩耗粉の平均粒径および摩耗痕の平均表面粗さの違いによるものと考えられる。 4.PSZおよびSi_3N_4のピンを用いた場合、他のセラミックスのピンを用いた場合と比較してWear lossは小さい値を示したが、Elution rateは大きな値を示した。 (2)チタンの摩耗挙動に及ぼす表面硬化処理の影響 1.C.P.チタン、β型チタン合金Ti-14Mo-3Nb-1.6Zrいずれにおいても、COガスによる表面硬化処理は、摩耗に伴う質量損失を減少させた。 2.COガスによる表面硬化処理は、β型合金よりもC.P.チタンで有効であった。これは、α相中への酸素および炭素の溶解度が大きく、表面最高硬さが大きいためである。 (3)摩耗紛の生体内外評価 1.生体環境でチタン粉末からはイオン溶出するが、イオン溶出量は摩耗試験における全体の中で占める割合は大きくない。 2.チタンイオンは、RAW264細胞の生存率を減少させ、SOD活性量やTNF-α分泌量にも影響を与えることがわかった。 3.RAW264細胞が直径約10μmのチタン粉末を貪食する様子が観察され、チタン粉末と細胞との活発な相互作用が示唆された。
撚り線構造を有するチタン合金製生体刺激用埋め込み電極の開発と特性評価

井口泰孝, 大内千秋, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：TOHOKU UNIVERSITY

2004年～ 2005年

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1.チタン製生体刺激用埋め込み電極の作製 (1)α+β型チタン合金Ti-4.5Al-6Nb-2Fe-2Mを素材とした直径100μmまでの線引きにおいて、チタンのような活性な材料の表面処理としては陽極酸化が有効であることおよび大気酸化を用いる場合にはできる限り低温で行う必要があることが示唆された。 (2)β型チタン合金Ti-14Mo-3Nb-1.5Zrを素材として直径42μmという極細線の作製に成功した。潤滑用酸化皮膜の作製には低温大気酸化を用いた。また、陽極酸化を利用して、直径100μmまでの線引きにも行った。陽極酸化を利用したものは比較的良好な表面性状を示した。 (3)4NのCPチタンを素材として直径47μmという細線の作製に成功した。従来、市販のチタン細線として得られる最も細い直径50μm(実測46μm)のものと比較して、開発材の表面性状は良好であった。 (4)α型Ti-10Zr合金を素材として直径51μmという細線の作製に成功した。合金線としては表面性状が良好であり、また機械的特性にも優れることから、直径51μmのTi-10Zr合金線を素線とした7本撚り線および7X7本撚り線を作製した。 2.特性評価 (1)開発CPチタン線直径50μm材では、最高引張強度980'MPaおよび引張伸び値3.5%が得られた。市販材と比較して強度、伸び値ともにわずかではあるが優れていた。また、α型Ti-10Zr合金細線やβ型Ti-14Mo-3Nb-1.5Zr合金細線においても機械的特性を評価した。 (2)回転曲げ疲労試験における疲労限は、開発CPチタン直径50μm材の200MPaに対し、市販直径50μm材では300MPaであった。10^7回まで破断しなかった両試料の疲労試験後の側面観察により、市販材において開発材よりも滑らかな表面となっており、疲労限への関連が示唆された。
低温プラズマ・水素還元法による高純度チタン粉末製造プロセスの研究

井口泰孝, 成島尚之, 大内千秋

2003年～ 2003年

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これまでSiF_4を原料とした太陽電池用シリコン粉末製造に使用されていた同軸マグネトロン型プラズマ処理法を応用して、クロール法と同じ原料の液体TiCl_4からのチタン製造プロセスの検討を行い、以下の結果を得た。 1.原料としてはTiCl_4の液体を用いるので、同軸マグネトロン型プラズマ処理装置のガス導入系を改良して液体原料を保持する容器を据え付けると共に、その蒸気をチャンバー内に搬送することができるようにした。 2.TiCl_4気化温度100〜150℃、水素流量80sccm、チャンバー圧力4Torr、RF入射電力1.5〜2kW、反射電力0.1KWとした合成条件下における2時間の反応により約20〜30%の収率で、主にTiCl_3粉末が得られた。TiCl_3は大気中の水蒸気の反応によりTicl_3・6H_2Oとして存在していた。また、一部TiO_xの存在もX線回折により確認された。 3.TiO_xの存在は、チタン金属粉末が大気中の酸素または水蒸気と反応して形成されたものと予想される。従って、原理的には、低温プラズマを利用した本方法によりTiCl_4(1)から金属チタンの製造は可能と思われる。Ticl_4の還元を十分進行させ、金属チタンの収率を向上させるためには、(i)水素ガスの供給量(分圧)を向上させる、(ii)チャンバー中の反応領域の体積を増加させるなどの対応が有効と考えられる。
炭化ケイ素結晶の異方性:高温酸化と表面プロセス変形によるアプローチ

成島尚之, 井口泰孝, 大内千秋

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2002年～ 2003年

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炭化ケイ素(SiC)の物理的および化学的特性の結晶方位異方性を明らかにすることを目的に以下の研究を行った。 1.炭化ケイ素のオゾンガス酸化 CVD法により合成された炭化ケイ素および単結晶炭化ケイ素ウエハを試料として、オゾンガス-酸素混合ガス中(最大オゾンガス分圧:0.07atm)、573〜1273Kの温度範囲で試料表面に形成されるシリカ皮膜厚さをエリプソメータで測定することにより酸化速度を評価した。オゾン含有雰囲気においても、これまで純酸素中や酸素-水蒸気混合ガス中で報告されているように、全実験温度範囲で(0001)Si面よりも(0001^^-)C面で酸化速度の大きいことが確認された。また、単結晶炭化ケイ素試料を用いた検討から酸化速度は以下の順に大きいことが明らかとなった。 (0001^^-)>(12^^-10)>(101^^-0)>(0001) この順番は各結晶面におけるC原子密度と良く対応しており、酸化プロセスに炭化ケイ素中のC原子が重要な役割を果たすことが示唆された。オゾン含有雰囲気においてはSi面における酸化速度が、純酸素中や酸素-水蒸気混合ガス中と比較して相対的に上昇していた。オゾンガスは酸化皮膜中の炭素濃度を減少させることを考え併せれば、炭化ケイ素Si面を用いた半導体プロセスにおけるオゾンガスの有用性が確認されたこととなる。 2.炭化ケイ素表面プロセス変形 2473Kにおいてon-axis材およびoff-axis材の熱処理に伴うネガティブクリスタル形状変化観察を行った。{0001}面が安定であること、および{121^^-0}面が不安定であることを明らかにした。また表面化学ポテンシャルの違いを駆動力としたモデル計算からの計算結果より、on-axis材に関しては表面着脱が律速段階であること、off-axis材については表面拡散が律速段階に関与することが示唆された。
鉄鋼精錬スラグを原料とした蓄熱システム用吸着剤の開発

大内千秋, 渡辺雅俊, 佐原亮二, 成島尚之, 大内千秋

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：TOHOKU UNIVERSITY

2002年～ 2003年

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ゼオライトへの水蒸気吸着熱を利用した蓄熱システムはエネルギー密度が高いことおよびプロセスの自由度の高さから注目されている。A型ゼオライト(M_x[Al_xSi_<1-x>O_2]・nH_2O)は構成組成としてSi:Alがモル比で最高1:1であるため、ゼオライトの中でも親水性が高く水蒸気吸着特性に優れる。高炉スラグは、SiO_2-Al_2O_3-CaO-MgOから構成されているため、CaやMgがA型ゼオライト中にMとして取り込まれることを考えれば、A型ゼオライト合成の有力な原料である。以上を踏まえ、SiO_2-Al_2O_3-CaO三元系合成スラグおよび実プロセスで得られた高炉スラグを原料として、NaOH溶液中でA型ゼオライト合成を目的としたアルカリ水熱合成を行った結果を以下に示す。 1.15mass%CaOを含有したSiO_2-Al_2O_3-CaO三元系合成スラグを原料とした合成実験により、328〜393K、NaOH濃度=0.5-3M、反応容器に投入するNaOH溶液質量と合成スラグ質量の比、M_<sol>/M_<slag>=15(ml/g)において、A型ゼオライトが合成されることがわかった。 2.合成されたA型ゼオライトは873Kまで安定であった。 3.高炉スラグから水熱合成によりA型ゼオライトを合成するためには成分調整が必要であった。含有されるCaO+MgO含有量を減少させるほどアルカリ水熱処理後の生成物中A型ゼオライトの割合が増加した。A型ゼオライトを合成するためにはCaO+MgO<30mass%にすることが必要である。 4.ボールミル型反応容器を使用することで、28.8ksと短時間でA型ゼオライトが形成されることを確認した。 5.CaO+MgO=15mass%と成分調整した高炉スラグからの生成物では、昇温に伴い水蒸気脱離に伴う吸熱が確認され、蓄熱材料としての有用性が示唆された。
回転曲げ疲労試験における生体内埋め込み金属電極の摩耗および元素溶出特性

井口泰孝, 成島尚之, 大内千秋

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：TOHOKU UNIVERSITY

2002年～ 2003年

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ステンレス鋼製生体刺激電極およびチタン製ワイヤーの回転曲げ疲労試験を310K、擬似体液中で行い、その疲労特性を明らかにした。 1.ステンレス鋼製生体刺激電極 (1)生体刺激用電極材料として開発されたFe-22Cr-10-Ni-6Mo-0.4Nオーステナイト系ステンレス鋼は、低曲げ応力領域において従来材であるSUS316Lよりも優れた疲労強度を示した。 (2)1%乳酸溶液中における溶出イオン濃度は、ステンレス鋼組成とほぼ一致した。一方、Hanks溶液中では、疲労試験時間に関係なくイオン溶出は低濃度に抑制された。また、検出されるイオン濃度は、Ni>Cr>Feとなることを明らかにした。 (3)疲労試験後にHanks溶液中における生成物として、棒状のβ-FeOOHの存在が確認された。β-FeOOH中にはCrが固溶していることがHanks溶液中における低いFeおよびCrイオン濃度の原因と考えられた。 2.チタン製ワイヤー (1)当研究室で開発したβ型チタン合金(Ti-14Mo-3Nb-1.5Zr-0.080)を素材として作製した直径100mmの細線では、C.P.Tiよりも高い疲労強度が得られた。 (2)市販の直径100μmのC.P.チタン細線の疲労強度は引張り強度の約3割に留まった。これは細線化プロセスにおいて形成された表面のクラックが疲労破壊の起点となったためと考えられる。 (3)DLC(diamond like carbon)をコーティングした直径100μmのC.P.チタン細線では、疲労強度は引張り強度の7割程度となった。これらは、DLCコーティングプロセスの最適化によりチタン細線の疲労特性が向上する可能性のあることを示唆する。
オゾンガスによるシリコンおよびシリコン基セラミックスの酸化機構解明

成島尚之, 井口泰孝

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：TOHOKU UNIVERSITY

1999年～ 2000年

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目的:シリコンデバイスの高集積化に伴うシリカ酸化皮膜形成方法の有力な手法であるオゾンガスによるシリコン基材料の酸化に関する基礎研究を目的として研究を行った。実験方法:酸化実験用試料には、n型シリコンウエハ、CVD炭化ケイ素および単結晶6H炭化ケイ素を用いた。オゾンガスの発生は放電式オゾナイザを用い、最大0.07atmのオゾン分圧を達成することができる。酸化温度は973Kとした。酸化速度の評価は形成された酸化皮膜厚さをエリプソメータを用いて測定することにより行った。結果: (1)酸化速度オゾン含有雰囲気における酸化速度はシリコン、炭化ケイ素いずれにおいても放物線則で説明することができた。純酸素中と比較すると非常に大きな酸化速度が得られた。純酸素中では酸化速度は、シリコン、炭化ケイ素C面、炭化ケイ素Si面となることが報告されているが、オゾン含有雰囲気では、炭化ケイ素C面の酸化速度がシリコンのよりも大きくなるという特異な挙動が観察された。炭化ケイ素C面上に形成される酸化皮膜中には、オゾン酸化後に炭素の存在がSIMSにより確認された。この炭素が酸化速度に影響を及ぼしていると考えられる。 (2)酸化速度のオゾン分圧依存性オゾンガス分圧と放物線速度定数との間には比例関係が得られた。オゾンガスの解離により形成される原子状酸素の酸化皮膜中を通る拡散が律速段階であると結論づけられる。また、この比例領域で酸化速度定数の温度依存性を検討することにより、意味のある活性化エネルギーが得られると予想され、将来的には、より低温における酸化速度の研究に関する指針も与えることができた。また、オゾン酸化速度に及ぼすArガスおよびCO_2ガス分圧の影響を調べたところ、オゾンガスの解離を促進するCO_2ガスにおいて、酸化速度が増加し、原子状酸素の拡散律速が確かめられた。
生体内長期埋め込みを想定した機能的電気刺激電極用新合金の開発および特性評価

井口泰孝, 飯久保知人, 半田康延, 星宮望, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B).

研究機関：Tohoku University

1998年～ 2000年

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機能的電気刺激(Functional Electrical Stimulation:FES)に使用する生体内長期埋め込み電極用の合金に関する研究を行い、以下の成果を得た。 1.新合金の設計:新合金設計のためのデータベースを整備して生体親和性、機械的強度、耐食性、磁性、加工性等の観点から合金組成を検討し、ニッケルの代替としてマンガン、窒素を添加し、クロム、ニッケル量を調整したオーステナイト系ステンレス鋼数種のインゴットを試作し、得られた新合金の加工率と引張強さ、延び、絞り等の関係を検討した。その結果、マンガン6%,ニッケル10%,クロム22%,モリブデン2%,窒素0.4%という組成を持つ合金(以下NAS106N)が最も極細線の製造に適する事を確認し、この材料で生体埋め込み電極用の極細線ワイヤーロープを試作した。 2.新合金で作製した生体埋め込み電極の評価:新合金NAS106N,従来より生体埋め込み電極に使用されているオーステナイト系ステンレス鋼SUS316L,従来歯科材料等に使用されているコバルト・クロム基合金NAS604PHの3種の合金で製造した電極用ワイヤーについて、磁気ヒステリシスの測定を行ない、NAS106NおよびNAS604PHでは強磁性相がほぼ存在しない事を確認した。さらに、大気中および生理食塩水中での回転曲げ疲労試験の結果から、大気中および高応力条件下の生理食塩水中ではNAS106Nの耐疲労性が最も優れている事を確認した。しかし、試験時間の長い低応力条件下では擦過腐食の影響により、他の合金と同程度の寿命となる事も判明した。また、有害元素であるニッケルイオンの溶出はNAS106Nで最も少ない事を確認した。以上を総括すると、本研究で開発した新合金NAS106Nは生体内長期埋め込み電極用合金として従来材に比較して極めて優れた性質を有するが、擦過腐食に関する特性改善が今後の課題と考えられる。
オゾンガスによるシリコンおよびシリコン基セラミックスの酸化機構解明

成島尚之

1998年～ 1998年
ラマン分光法による溶融アルミニウム合金表面上における酸化皮膜形成過程のその場観察

成島尚之, 井口泰孝

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：TOHOKU YNIVERSITY

1996年～ 1997年

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ラマン分光法により1273K、純酸素中において溶融純AlおよびAl-Mg合金上に形成される酸化皮膜形成過程のその場観察を行うと共に、酸化に伴う質量変化を測定することにより以下の結果を得た。 1.溶融Al合金の酸化挙動は、酸化初期、酸化潜伏期および酸化進行期の三段階よりなっていることがわかった。しかしながら、溶融純Alや溶融Al-4mass%Mg、溶融Al-4mass%Mg-1mass%Si、溶融Al-4mass%Mg-4mass%Siでは酸化潜伏期が観察されなかった。 2.酸化初期にはMg蒸気の関与する酸化反応が起こり、MgOやスピネル相(MgO・Al^2O^3)が形成された。酸化潜伏期にはスピネル相を通してのAl融体の浸透が起こり、この浸透の完了が酸化進行期を出現させる。酸化進行期においては主にα-Al^2O^3が形成され、大きな酸化速度が観察される。 3.酸化進行期を迎える溶融Al-1mass%Mgおよび酸化進行期が観察されない溶融Al-4mass%Mgについて、ラマン分光法により酸化皮膜形成過程のその場観察を行った。溶融Al-1mass%Mg合金では、昇温過程よりスピネル相(MgO・Al^2O^3)が同定され、1273K付近よりα-Al^2O^3も同時に観察された。1273Kにおける保持の間、周期的にスピネル相とα-Al^2O^3のラマン線が消えるという現象が確認された。この原因としては、形成される酸化皮膜(スピネル相およびα-Al^2O^3)の割れに伴い、Al融体が酸化皮膜表面に存在したためと考えられる。酸化皮膜の割れは、高温顕微鏡による酸化過程のその場観察でも認められた。また、EPMAを用いた酸化皮膜断面の組成分析でも下地金属に平行にスピネル相が検出されたことからも示唆される。一方、溶融Al-4mass%Mg合金では、1273Kよりスピネル相の形成が観察された。以降、5時間までラマンスペクトルに大きな変化はなかった。これは、スピネル相中を通してのAl融体の浸透が完了していないことを意味する。
インプランタブル機能的電気刺激用電極の開発

井口泰孝, 成島尚之, 国分馨, 半田康延, 星宮望

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (A)

研究機関：TOHOKU UNIVERSITY

1994年～ 1996年

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手足が運動麻痺している脊髄損傷患者、脳卒中患者に対して、麻痺した末梢神経・筋系にプログラムされた電気刺激を与え、麻痺部位の機能を再建する機能的電気刺激(Functional Electrical Stimulation:FES)は有効である。申請者らは経皮的筋内埋め込み電極を用いた刺激装置を開発し、臨床的に使用している。本システムは刺激電極が皮膚を貫通して体内に埋め込まれるため、刺入部の感染、断線の可能性、注意深い手入れの必要性、外観上の抵抗感等の欠点がある。そのため、インプランタブル機能的電気刺激装置の開発が急務である。本研究では、現在の経皮的埋め込み電極より、一層信頼性の高い完全体内埋め込みシステム用の電極開発を目的としており、下記の成果が得られた。 1.従来のSUS316Lステンレス鋼細線に加えクロム-コバルト基合金である604PHを用い径25μmの細線加工を行い十分な機械的性質を有する電極を作製した。 2.SUS316L細線は塩素イオンを含む溶液(生理食塩水)中の電荷負荷加速腐食試験により孔食(pitting corosion)が認められた。一方、604PHでは孔食は全く認められず、高い耐食性を示した。インプランタブル機能的電気刺激用電極として、刺激装置との接続可能なコネクターおよび電極先端形状を開発した。これを用いることにより埋め込み手術中容易に20本以上の電極を安定して結合できた。現在、完全埋め込み型刺激装置のプロトタイプと2種類の電極(SUS316L細線および604PH細線)を用い、山羊へ埋め込み、システム全体の動作試験を行っている。本格的なシステム開発への有用な知見が期待される。
二次イオン質量分析法による高温酸化皮膜中の水素分析に関する研究

成島尚之, 井口泰孝

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for General Scientific Research (C)

研究機関：TOHOKU UNIVERSITY

1994年～ 1995年

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◯二次イオン質量分析法(SIMS)による水素分析:前年度に水素分析用標準試料として採用したプロトンを打ち込んだシリカ皮膜中の水素分析を二次イオン質量分析法により行い、最適分析条件を明らかにした。水素分析のためには、一次イオン種、検出二次イオン種の選定の他に、一次イオン照射ラスターサイズや二次イオン採取領域が分析精度に影響を与えることがわかった。 ◯酸化速度測定:化学気相析出法により合成した炭化ケイ素および窒化ケイ素の酸化速度に及ぼす水蒸気分圧および酸素分圧の影響を明らかにすると共に、酸化過程で形成される酸化皮膜の分析をX線回析、顕微ラマン分光法により行った。水蒸気分圧上昇および酸素分圧減少に伴い、酸化速度は増加した。この原因は、酸化皮膜(シリカ)中のミクロ的な欠陥構造が酸化雰囲気により変化するためと考察した。酸化皮膜のX線分析により、雰囲気中に存在する水蒸気は高温(1873K以上)では酸化皮膜の非晶質化を促進し、低温(1373K付近)では結晶質化を促進することが明らかになった。また顕微ラマン分光法による酸化皮膜断面観察により、湿潤雰囲気中において形成される酸化皮膜は皮膜/材料界面においては結晶質相(クリストバライト)、皮膜/ガス界面においては非晶質相(非晶質シリカ)という二重構造を有することを明らかにした。つまり、雰囲気中に存在する水蒸気は結晶質シリカを非晶質化し、その非晶質化がシリコン気セラミックスの耐酸化特性を劣化させるものと考えられる。
迅速顕微ラマン測定法を用いた金属酸化過程のその場観測装置の開発

嵐治夫, 清水良祐, 成島尚之, 井口康孝

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Developmental Scientific Research (B)

研究機関：TOHOKU UNIVERSITY

1993年～ 1994年

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本研究ではレーザラマン分光法を非破壊で局所領域の分析が可能であるという特色に着目し、さまざまな雰囲気における耐熱金属材料の高温における酸化挙動を"その場"観測できる迅速顕微ラマン測定装置の開発を行うことを目的とした。本研究では、焦点距離64cmのトリプルモノクロメータとCCD型の光検知器を組み合わせて超高感度迅速ラマン散乱測定装置を開発した。この装置の開発しは国内外にで先駆的なものであり、耐熱金属の酸化過程の研究へ適用し、種々の雰囲気ガス中で時間分解しながら"その場"で酸化挙動の素過程をミクロな立場から明らかにできるようになった。開発した超高感度迅速ラマン散乱測定装置を用いて、Fe-6.5mass%Siの純O_2、純CO_2雰囲気中、1073Kでラマンスペクトルの"その場"測定を行うことにより、純O_2、純CO_2雰囲気中での酸化機構の違いは、表面SiO_2層の酸素欠陥濃度の差によることを明らかにした。また、溶湯表面の酸化皮膜が鋳造時の問題となっているAl、Al-Mg合金について酸化機構の解明にも開発した装置を使用した。Al、Al-Mg合金溶湯においてはこれまで報告されている最高温度よりも高い1273Kで"その場"観測を行うことに成功した。その結果、Al-1mass%Mgが最も激しく酸化が進行し、それは初期に形成されるMgO皮膜の量に依存することがわかった。本研究において開発した超高感度迅速ラマン散乱測定装置を用いて金属の酸化過程を"その場"観測することにより、従来困難であった1273Kにおけるラマン散乱スペクトルの"その場“観測が初めて可能となり、このシステムが高温における金属の酸化機構の解明に有効であることが明らかにされた。
III-V族化合物半導体単結晶成長時のフラックスと原料融体間の各種元素の分配

井口泰孝, 渡辺雅俊, 成島尚之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for General Scientific Research (B)

研究機関：TOHOKU UNIVERSITY

1993年～ 1994年

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前年度にIII族金属酸化物-B_2O_3二元系フラックスおよび溶融III族金属に関する検討を行っており、本年度はB_2O_3二元系フラックス-溶融III族金属間の酸素の分配平衡を明らかにした。 1.Ga_2O_3‐B_2O_3二元系フラックスと溶融Ga間の酸素分配 1423Kにおいてフラックス中のGa_2O_3濃度と溶融Ga中の溶存酸素濃度を定量し、酸素分配比((mol%Ga_2O_3)/[mass%O]^3)を決定した。分配比はGa_2O_3濃度の上昇に伴い減少する傾向が見られた。溶融Ga中の溶存酸素濃度からフラックス中のGa_2O_3の活量を算出した。 2.In_2O_3‐B_2O_3二元系フラックスと溶融In間の酸素分配 1373および1473Kにおいてフラックス中のIn_2O_3濃度と溶融In中の溶存酸素濃度を定量し、Ga系と同様に酸素分配比((mol%In_2O_3)/[mass%O]^3)を決定した。分配比はIn_2O_3濃度にほとんど依存しないことがわかった。溶融In中の溶存酸素濃度からフラックス中のIn_2O_3の活量を算出した。 Ga系、In系いずれにおいてもフラックス中のIII族酸化物活量は非常に小さな値(純物質基準で0.01以下)となった。これは、実操業においても原料融体中の溶存酸素が低濃度に抑えられていることを意味する。しかしながら、物理化学的には現時点においてIII族金属酸化物-B_2O_3二元系のIII族金属酸化物側の状態図(B_2O_3固溶度)が不明であるため、III族酸化物活量の理想溶液からの偏倚を検討することができていない。将来的にはGa_2O_3‐B_2O_3固溶体中のGa_2O_3活量およびInBO_3中のIn_2O_3活量を明らかにすると共に、さらに詳細なIII族金属酸化物-B_2O_3二元系状態図の作製が必要である。
ラマン分光法によるシリカ酸化皮膜の結晶化のその場観察とその酸化速度に及ぼす影響

成島尚之

1991年～ 1991年
シリコン基セラミックスの超高温低酸素分圧下における酸化機構

成島尚之

1989年～ 1989年

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