顔写真

ナカヤ ナオキ
中谷 直樹
Naoki Nakaya
所属
東北メディカル・メガバンク機構 予防医学・疫学部門
職名
教授
学位
  • 博士(障害科学)(東北大学)

  • 修士(障害科学)(東北大学)

経歴 11

  • 2021年 ~ 継続中
    北海道大学大学院保健科学院 客員教授

  • 2021年 ~ 継続中
    東北大学東北メディカル・メガバンク機構 予防医学・疫学部門 教授

  • 2019年 ~ 2021年
    埼玉県立大学保健医療福祉学部健康開発学科、埼玉県立大学大学院保健医療福祉学研究科 教授

  • 2019年 ~ 2020年
    東北大学東北メディカル・メガバンク機構 客員教授

  • 2015年 ~ 2019年
    東北大学東北メディカル・メガバンク機構予防医学・疫学部門 准教授

  • 2012年 ~ 2015年
    東北大学東北メディカル・メガバンク機構予防医学・疫学部門 講師

  • 2010年 ~ 2012年
    鎌倉女子大学家政学部管理栄養学科 専任講師

  • 2008年 ~ 2010年
    日本学術振興会海外特別研究員 (所属:Visiting Researcher, Psychosocial Cancer Research, Danish Cancer Society, Copenhagen, Denmark)

  • 2005年 ~ 2008年
    東北大学大学院医学系研究科公衆衛生学分野 助手(助教)

  • 2004年 ~ 2005年
    (財)がん研究振興財団リサーチ・レジデント (所属:国立がんセンター研究所支所精神腫瘍学研究部)

  • 2003年 ~ 2004年
    東北大学 研究支援員 (所属:東北大学大学院医学系研究科公衆衛生学分野)

︎全件表示 ︎最初の5件までを表示

学歴 3

  • 東北大学大学院医学系研究科障害科学専攻博士課程後期3年の課程 修了 東北大学 博士(障害科学)

    2003年 ~

  • 東北大学大学院医学系研究科障害科学専攻博士課程前期2年の課程 修了 東北大学 修士(障害科学)

    2000年 ~

  • 麻布大学環境保健学部環境保健学科卒業

    1998年 ~

委員歴 56

  • 査読)J Psychiatric Research (2022年×2、2023年×2)

    2022年 ~ 継続中

  • Reviewer Board)Japanese Journal of Clinical Oncology (2021-)

    2021年 ~ 継続中

  • 査読)Perspectives in Public Health

    2021年 ~ 継続中

  • 査読)Preventive Medicine(2021×2)

    2021年 ~ 継続中

  • 査読)Public Health (2021×3, 2022×1)

    2021年 ~ 継続中

  • 委員) 戸田市保健対策推進協議会委員(会長)

    2019年4月 ~ 2021年3月

  • 委員)日本疫学会評議員 2013-14、 日本疫学会代議員 2015-16, 2017-18, 2021-22, 2023-24

    2016年 ~ 2019年

  • 委員) 弘前大学COI健康・医療データ連携推進機構運営委員会 委員

    2017年 ~ 2018年

  • 査読)日本行動医学会プログラム編集員

    2015年 ~ 2015年

  • 委員) 国際行動医学会プログラム編集委員:

    2008年 ~ 2008年

  • Dementia and Geriatric Cognitive Disorders(2023年)

    2023年 ~

  • 委員)日本サイコオンコロジー学会 代議員 2023-24

    2023年 ~

  • 査読) Journal of Alzheimer’s Disease

    2023年 ~

  • 査読)Disaster Medicine and Public Health Preparedness

    2021年 ~

  • 査読)Preventive Medicine Reports(2020, 2024)

    2020年 ~

  • 査読)Complementary Therapies in Clinical Practice (×2)

    2020年 ~

  • 査読)Environmental Health and Preventive Medicine(2020✖2)

    2020年 ~

  • 査読)European Journal of Clinical Nutrition(2020✖2)

    2020年 ~

  • 査読)BMC Medical Research Methodology

    2020年 ~

  • 査読)Journal of Psychosocial Oncology Research and Practice (2019, 2020)

    2019年 ~

  • 査読)Japanese Journal of Clinical Oncology

    2019年 ~

  • 査読)Neuropsychopharmacology Reports

    2019年 ~

  • 査読)Psychiatry and Clinical Neruoscience

    2018年 ~

  • 査読)Social Psychiatry and Psychiatric Epidemiology (2018, 2020×5, 2021×2)

    2018年 ~

  • 査読)Scientific Reports (2018年, 2022年)

    2018年 ~

  • 査読)Disability and Rehabilitation (2017年、2018年×2、2023年×2)

    2017年 ~

  • 査読)Tohoku Journal of Experimental Medicine (2017年、2019年×2、2022年)

    2017年 ~

  • 査読)Journal of Atherosclerosis and Thrombosis

    2017年 ~

  • 査読)Case Reports in Medicine

    2017年 ~

  • 査読) BMJ Open(2016年、2022年×2)

    2016年 ~

  • 査読)Journal of Negative Results in BioMedicine

    2016年 ~

  • 査読)BMC Geriatrics

    2015年 ~

  • 査読)Cancer Epidemiology

    2015年 ~

  • 査読)European Journal of Public Health

    2014年 ~

  • 査読)Environmental Health and Preventive Medicine(2014年、2015年、2018年)

    2014年 ~

  • 査読) Plos One (2014年*2, 2016年)

    2014年 ~

  • 査読) British Journal of Cancer

    2013年 ~

  • 査読) Journal of Physical Therapy Science

    2013年 ~

  • 査読) International Journal of Neuroscience

    2013年 ~

  • 査読) BMC Cancer

    2013年 ~

  • 査読) Journal of the National Cancer Institute

    2012年 ~

  • 査読) Psychooncology (2012年、2013年、2014年、2015年、2018年)

    2012年 ~

  • 査読) European Journal of Psychotherapy & Counselling

    2012年 ~

  • 査読) Nephrology Dialysis Transplantation

    2012年 ~

  • 査読) Journal of Affective Disorders (2012年、2016、2017年、2018年×2、2019年×2、2020年×3、2023年)

    2012年 ~

  • 査読) Patient Preference and Adherence

    2011年 ~

  • 査読) Spanish Journal of Psychology

    2011年 ~

  • 査読) 行動医学研究

    2010年 ~

  • 査読) American Journal of Epidemiology

    2010年 ~

  • 査読) International Journal of Cancer (2009年、2015年、2018年×2)

    2009年 ~

  • 査読) Journal of Epidemiology (2008年、2009年、2010年、2012年、2014年、2015年、2020年×2、2021年×3)

    2008年 ~

  • 査読) BMC Public Health

    2008年 ~

  • 査読) BioPsychoSocial Medicine

    2008年 ~

  • 査読) Acta Oncologica

    2008年 ~

  • 査読) Preventive Medicine

    2007年 ~

  • 査読) Journal of Psychosomatic Research(2007、2020)

    2007年 ~

︎全件表示 ︎最初の5件までを表示

所属学協会 3

  • 日本公衆衛生学会

  • 日本サイコオンコロジー学会

  • 日本疫学会(上級疫学専門家2019-)

研究キーワード 33

  • 一般地域住民

  • 生存分析

  • 危険因子

  • 生活習慣

  • 前立腺がん

  • 心理社会的要因

  • 健康影響

  • 身体的要因

  • 症例対照研究

  • ストレス

  • 縦断的研究

  • がん患者

  • 配偶者

  • がん

  • 心理的苦痛

  • 前向きコホート研究

  • 疫学

  • 自殺

  • うつ

  • 集団認知行動療法

  • カテキン

  • 緑茶

  • ω3系脂肪酸

  • サイコオンコロジー (Psychooncology)

  • 応用健康科学 (Applied Health Science)

  • 公衆衛生学 (Public Health)

  • 疫学 (Epidemiology)

  • Public Health

  • Epidemiology

  • Applied Health Science

  • Stress Science

  • Behavioral Medicine

  • Psychosomatic Medicine

研究分野 3

  • 社会基盤(土木・建築・防災) / 防災工学 /

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない /

  • ライフサイエンス / 栄養学、健康科学 /

受賞 7

  1. 日本疫学会優秀査読者賞, 2022年

    2022年

  2. 日本疫学会総会ポスター賞, 2016年1月

    2016年

  3. 「黒川利雄がん研究基金」研究助成金 採択, 2014年6月

    2014年 財団法人宮城県対がん協会

  4. 日本疫学会奨励賞, 2013年 1月

    2013年

  5. 日本行動医学会 荒記記念賞, 2007年 3月

    2007年

  6. 日本心身医学会 池見賞, 2005年 4月

    2005年

  7. 麻布大学環境科学研究会越智賞, 2000年 9月

    2000年

︎全件表示 ︎最初の5件までを表示

論文 374

  1. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. 国際誌

    Yoshiaki Noji, Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Tomohiro Nakamura, Naho Tsuchiya, Haruki Momma, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Ryoichi Nagatomi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    BMC public health 24 (1) 714-714 2024年3月5日

    DOI: 10.1186/s12889-024-18244-z  

    詳細を見る 詳細を閉じる

    BACKGROUND: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. METHODS: We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. RESULTS: Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. CONCLUSIONS: Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.

  2. Dietary habits and plasma lipid concentrations in a general Japanese population. 国際誌

    Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

    Metabolomics : Official journal of the Metabolomic Society 20 (2) 34-34 2024年3月5日

    DOI: 10.1007/s11306-024-02087-1  

    詳細を見る 詳細を閉じる

    INTRODUCTION: Accumulating data on the associations between food consumption and lipid composition in the body is essential for understanding the effects of dietary habits on health. OBJECTIVES: As part of omics research in the Tohoku Medical Megabank Community-Based Cohort Study, this study sought to reveal the dietary impact on plasma lipid concentration in a Japanese population. METHODS: We conducted a correlation analysis of food consumption and plasma lipid concentrations measured using mass spectrometry, for 4032 participants in Miyagi Prefecture, Japan. RESULTS: Our analysis revealed 83 marked correlations between six food categories and the concentrations of plasma lipids in nine subclasses. Previously reported associations, including those between seafood consumption and omega-3 fatty acids, were validated, while those between dairy product consumption and odd-carbon-number fatty acids (odd-FAs) were validated for the first time in an Asian population. Further analysis suggested that dairy product consumption is associated with odd-FAs via sphingomyelin (SM), which suggests that SM is a carrier of odd-FAs. These results are important for understanding odd-FA metabolism with regards to dairy product consumption. CONCLUSION: This study provides insight into the dietary impact on plasma lipid concentration in a Japanese population.

  3. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. 国際誌

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 47 (3) 586-597 2024年3月

    DOI: 10.1038/s41440-023-01484-8  

    詳細を見る 詳細を閉じる

    Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.

  4. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. 国際誌

    Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Atsushi Shimizu, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 2024年2月29日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41440-024-01582-1  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23–45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.

  5. Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

    Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology 2024年2月24日

    DOI: 10.2188/jea.JE20230241  

    詳細を見る 詳細を閉じる

    BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.

  6. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 2024年2月6日

    DOI: 10.5551/jat.64535  

    詳細を見る 詳細を閉じる

    AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.

  7. Association of parity with the prevalence of hypertension in Japan: The Tohoku Medical Megabank Community-based cohort study. 国際誌

    Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

    Journal of clinical hypertension (Greenwich, Conn.) 26 (2) 102-121 2024年2月

    DOI: 10.1111/jch.14756  

    詳細を見る 詳細を閉じる

    This study investigated the association of parity with hypertension prevalence in Japanese women while considering a clinical history of hypertensive disorders of pregnancy (HDP) and menopausal status. This cross-sectional study included 30,530 Japanese women (6700 premenopausal; 23 830 postmenopausal). The association between parity and the prevalence of hypertension was evaluated using a multiple logistic regression model with possible confounders. In premenopausal women, no statistically significant association between parity and hypertension prevalence was found. When not adjusted for current body mass index (BMI), a linear graded association was observed between parity and the prevalence of hypertension in postmenopausal women. However, the association between parity and hypertension prevalence in postmenopausal women was attenuated after adjustment for current BMI. Both current BMI and a clinical history of HDP were significantly associated with a high risk of hypertension in both premenopausal and postmenopausal women. Our results also suggest that continuous surveillance and preventive measures for hypertension should be provided for women with HDP and high parity.

  8. A feasibility study of provider-level implementation strategies to improve access to colorectal cancer screening for patients with schizophrenia: ACCESS2 (N-EQUITY 2104) trial. 国際誌

    Masaki Fujiwara, Yuto Yamada, Tsuyoshi Etoh, Taichi Shimazu, Masafumi Kodama, Norihito Yamada, Takahiro Asada, Shigeo Horii, Takafumi Kobayashi, Teruo Hayashi, Yoshitaka Ehara, Kenji Fukuda, Keita Harada, Maiko Fujimori, Miyuki Odawara, Hirokazu Takahashi, Shiro Hinotsu, Naoki Nakaya, Yosuke Uchitomi, Masatoshi Inagaki

    Implementation science communications 5 (1) 2-2 2024年1月4日

    DOI: 10.1186/s43058-023-00541-0  

    詳細を見る 詳細を閉じる

    BACKGROUND: People with schizophrenia have a lower colorectal screening rate than the general population. A previous study reported an intervention using case management to encourage colorectal cancer screening for patients with schizophrenia in psychiatric outpatient settings. In this feasibility study, we developed provider-level implementation strategies and evaluated the feasibility of conducting a definitive trial in terms of the penetration of the intervention assessed at the patient level. Additionally, we examined the fidelity of strategies to implement the intervention at the provider level in a routine clinical psychiatric setting. METHODS: This was a multicenter, single-arm feasibility study with medical staff at psychiatric hospitals in Japan. The provider-level implementation strategies developed in this study included three key elements (organizing an implementation team appointed by the facility director, interactive assistance using a clear guide that outlines who in the hospital should do what, and developing accessible educational materials) to overcome major barriers to implementation of the intervention and four additional elements (progress monitoring, joint meetings and information sharing among participating sites, adaptation of encouragement methods to specific contexts, and education of on-site staff), with reference to the elements identified in the Expert Recommendations for Implementing Change (ERIC). The feasibility of the strategies was evaluated by the proportion of patients who were eligible for encouragement (patients with schizophrenia aged 40, 50, or 60) who received encouragement. We set the goal of providing encouragement to at least 40% of eligible patients at each site. RESULTS: Two public and four private psychiatric hospitals in Okayama and Shimane prefectures participated in this study. Regarding fidelity, all elements of the strategies were conducted as planned. Following the procedures in the guide, each team prepared and provided encouragement according to their own facility and region. Penetration, defined as the proportion of eligible patients who received encouragement, ranged from 33.3 to 100%; five of the six facilities achieved the target proportion. CONCLUSIONS: The provider-level implementation strategies to implement encouragement were feasible in terms of penetration of the intervention assessed at the patient level. The results support the feasibility of proceeding with a future definitive trial of these strategies. TRIAL REGISTRATION: jRCT, jRCT1060220026 . Registered on 06/04/2022.

  9. The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study. 国際誌

    Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Hideaki Hashimoto, Tomohiro Nakamura, Kotaro Nochioka, Taku Obara, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 46 (12) 2718-2728 2023年12月

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41440-023-01454-0  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    Abstract This study aimed to examine whether risk of withdrawal from HTTx was higher in coastal areas that were severely damaged by tsunami than in inland areas. We conducted a cross-sectional study of 9218 participants aged ≥20 years in Miyagi, Japan. The odds ratios (ORs) and confidence interval (CI) for withdrawal from HTTx in coastal and inland groups were compared using multivariate logistic regression analysis, adjusting for potential confounders. In total, 194 of 5860 and 146 of 3358 participants in the inland and coastal groups, respectively, withdrew from HTTx treatment. OR (95%CI) of withdrawal from HTTx in the coastal group was 1.46 (1.14–1.86) compared to the inland group. According to housing damage, ORs (95% CI) in the no damage, partially destroyed, and more than half destroyed coastal groups compared with the no damage inland group were 1.62 (1.04–2.50), 1.69 (1.17–2.45), and 1.08 (0.71–1.65), respectively. In conclusion, the risk of HTTx withdrawal for participants whose homes in coastal areas were relatively less damaged was significantly higher compared with those in inland areas, while the risk of HTTx withdrawal for participants whose homes were more than half destroyed was not. Post-disaster administrative support for disaster victims is considered vital for continuation of their treatment.

  10. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Journal of atherosclerosis and thrombosis 30 (12) 1950-1965 2023年12月1日

    DOI: 10.5551/jat.64425  

    詳細を見る 詳細を閉じる

    AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.

  11. Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Taku Obara, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Junichi Sugawara, Eiichi N Kodama, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 30 (12) 1905-1916 2023年12月1日

    DOI: 10.5551/jat.64151  

    詳細を見る 詳細を閉じる

    AIM: People with high normal blood pressure (BP) have a higher risk of cardiovascular events than those with normal BP; therefore, progression to hypertension (HT) should be prevented. We aimed to assess the HT risk using central BP and carotid intima media thickness (CIMT) in people with high normal BP. METHODS: This prospective cohort study used the Tohoku Medical Megabank Community-Based Project Cohort Study (conducted from 2013 in Miyagi Prefecture in Japan). The participants had a high normal BP, defined as a systolic BP of 120-139 mmHg and diastolic BP <90 mmHg using brachial BP measurement during the baseline survey. The outcome was new-onset HT during the secondary survey, conducted four years after the baseline survey. RESULTS: Overall, 4,021 participants with high normal BP during the baseline survey, with an average age of 58.7 years, were included; 1,030 (26%) were diagnosed with new-onset HT during the secondary survey, 3.5± 0.7 years after the baseline survey. The multivariable odds ratio (95% confidence interval) for HT in the highest versus lowest quartile of central BP was 1.7 (1.2-2.4, p=0.0030), and that of CIMT was 1.8 (1.4-2.4, p<0.001). Subgroup analysis according to age (<60 and ≥ 60 years) and sex revealed that the central BP was influential in groups with younger age and female individuals; CIMT was influential in all groups. CONCLUSIONS: Higher central BP and thicker CIMT at the baseline were correlated with new-onset HT in individuals with high normal BP, independent of brachial systolic BP and other cardiovascular risk factors.

  12. Effects of greenery at different heights in neighbourhood streetscapes on leisure walking: a cross-sectional study using machine learning of streetscape images in Sendai City, Japan. 国際誌 査読有り

    Shusuke Sakamoto, Mana Kogure, Tomoya Hanibuchi, Naoki Nakaya, Atsushi Hozawa, Tomoki Nakaya

    International journal of health geographics 22 (1) 29-29 2023年11月8日

    DOI: 10.1186/s12942-023-00351-6  

    詳細を見る 詳細を閉じる

    BACKGROUND: It has been pointed out that eye-level greenery streetscape promotes leisure walking which is known to be a health -positive physical activity. Most previous studies have focused on the total amount of greenery in the eye-level streetscape to investigate its association with walking behaviour. While it is acknowledged that taller trees contribute to greener environments, providing enhanced physical and psychological comfort compared to lawns and shrubs, the examination of streetscape metrics specifically focused on greenery height remains largely unexplored. Therefore, this study examined the relationship between objective indicators of street greenery categorized by height from a pedestrian viewpoint and leisure walking time. METHODS: We created streetscape indices of street greenery using Google Street View Images at 50-m intervals in an urban area in Sendai City, Japan. The indices were classified into four ranges according to the latitude of the virtual hemisphere centred on the viewer. We then investigated their relationship to self-reported leisure walking. RESULTS: Positive associations were identified between the street greenery in higher positions and leisure walking time, while there was no significant association between the greenery in lower positions. CONCLUSION: The findings indicated that streets with rich greenery in high positions may promote residents' leisure walking, indicating that greenery in higher positions contributes to thermally comfortable and aesthetic streetscapes, thus promoting leisure walking. Increasing the amount of greenery in higher positions may encourage residents to increase the time spent leisure walking.

  13. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. 国際誌

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Journal of Alzheimer's disease : JAD 95 (4) 1469-1480 2023年9月11日

    DOI: 10.3233/JAD-230318  

    詳細を見る 詳細を閉じる

    BACKGROUND: Olfactory function decline has recently been reported to be associated with a risk of cognitive impairment. Few population-based studies have included younger adults when examining the association between olfactory test data with multiple odor intensities and suspected cognitive impairment. OBJECTIVE: We investigated the association between high-resolution olfactory test data with fewer odors and suspected cognitive impairments. We also examined the differences between older and younger adults in this association. METHODS: The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered to 1,450 participants, with three odor-intensity-level olfactometry using six different odors. Logistic regressions to discriminate suspected cognitive impairment were conducted to examine the association, adjusted for age, sex, education duration, and smoking history. Data were collected from the Program by Tohoku University Tohoku Medical Megabank Organization, with an additional olfactory test conducted between 2019 and 2021. RESULTS: We generally observed that the lower the limit of distinguishable odor intensity was, the higher the MoCA-J score was. The combination of spearmint and stuffy socks contributed most to the distinction between suspected and unsuspected cognitive impairment. Furthermore, the association was significant in women aged 60-74 years (adjusted odds ratio 0.881, 95% confidence interval [0.790, 0.983], p = 0.024). CONCLUSIONS: The results indicate an association between the limit of distinguishable odor intensity and cognitive function. The olfactory test with multiple odor intensity levels using fewer odors may be applicable for the early detection of mild cognitive impairment, especially in older women aged 60-74 years.

  14. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 45回 261-261 2023年9月

    出版者・発行元:(NPO)日本高血圧学会

  15. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 45回 358-358 2023年9月

    出版者・発行元:(NPO)日本高血圧学会

  16. Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study. 国際誌

    Takashi Ohe, Mitsuhiro Yamada, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Nobuo Fuse, Shinichi Kuriyama, Ayumi Mitsune, Ayumi Suzuki, Shuichiro Matsumoto, Tetsuya Hatakeyama, Chikashi Iwasaki, Manami Suzuki, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Akira Koarai, Tsutomu Tamada, Masayuki Yamamoto, Masakazu Ichinose, Hisatoshi Sugiura

    Respiratory investigation 61 (5) 588-600 2023年9月

    DOI: 10.1016/j.resinv.2023.06.004  

    詳細を見る 詳細を閉じる

    BACKGROUND: Birth weight, as a measure of intrauterine growth, is commonly used in epidemiological studies and is reported to be associated with adult lung function. However, findings regarding this association in previous studies have been inconsistent. Furthermore, no studies have reported associations stratified by age or smoking status, or adjusted for eosinophil count or other parameters related to type 2 airway inflammation. METHODS: This cross-sectional study included 2632 men and 7237 women aged ≥20 years living in Miyagi Prefecture, Japan. Lung function was assessed based on spirometry. Birth weight data were obtained through a questionnaire survey. Analysis of covariance was used to evaluate the associations between birth weight and lung function, adjusting for potential confounders. Stratified analyses by age and smoking status were also conducted, together with a sub-analysis for low birth-weight participants. RESULTS: Birth weight was positively associated with forced expiratory volume in 1 s (FEV1) for both sexes and with vital capacity in women, after adjusting for height, age, smoking status, and parameters related to type 2 airway inflammation. The stratified analysis for smoking status revealed associations in never-smokers and ex-smokers. When stratified by age, the associations were confirmed in middle-aged participants. The effect of smoking status on the FEV1 of low birth-weight participants was not significant. CONCLUSIONS: Our analysis of a large, Japanese adult population showed that birth weight was independently and positively associated with adult lung function, even after adjustment for age, height, smoking status, and parameters related to type 2 airway inflammation.

  17. Increasing disparities in cancer screening among people with severe mental illness during the COVID-19 pandemic. 国際誌

    Masaki Fujiwara, Yuto Yamada, Taichi Shimazu, Naoki Nakaya, Shiro Hinotsu, Maiko Fujimori, Yosuke Uchitomi, Masatoshi Inagaki

    Schizophrenia research 258 18-20 2023年8月

    DOI: 10.1016/j.schres.2023.07.006  

  18. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

    Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

    JMA journal 6 (3) 246-264 2023年7月14日

    DOI: 10.31662/jmaj.2022-0220  

    詳細を見る 詳細を閉じる

    The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.

  19. Perceptions toward issues in cancer care for people with mental illness among psychiatric care providers: A questionnaire study. 国際誌

    Yuto Yamada, Masaki Fujiwara, Tsuyoshi Etoh, Riho Wada, Shinichiro Inoue, Yoshiko Mimaki, Masafumi Kodama, Yusaku Yoshimura, Shigeo Horii, Takanori Matsushita, Maiko Fujimori, Taichi Shimazu, Naoki Nakaya, Shiro Hinotsu, Masahiro Tabata, Kenji Tamura, Yosuke Uchitomi, Norihito Yamada, Kiwamu Nagoshi, Masatoshi Inagaki

    Psycho-oncology 32 (7) 1022-1029 2023年7月

    DOI: 10.1002/pon.6143  

    詳細を見る 詳細を閉じる

    OBJECTIVES: To reduce cancer care disparities in people with mental illness, this study aimed to quantify psychiatric care providers' perceptions regarding issues that are insufficiently addressed or difficult to address. METHODS: Psychiatric care providers at 23 psychiatric hospitals in Japan were surveyed using mail questionnaires. Respondents were asked to rate 15 items with four categories related to insufficiencies/difficulties in cancer care for patients with mental illness on a five-point Likert scale. We analyzed the proportion of respondents who answered "insufficient/difficult" for each item. RESULTS: A total of 255 (76.3%) psychiatric care providers responded. For questions related to the skills and attitudes of psychiatric professionals, 48.3%-58.4% of respondents perceived that efforts for supporting cancer screening and treatment were insufficient. For the questions related to collaborations between cancer and psychiatric care providers, 75.3% of respondents perceived that inpatient visits between psychiatric and cancer hospitals were insufficient. For the questions related to in-psychiatric-hospital medical systems, 50.2%-87.2% of respondents perceived that support for screening, diagnosis/treatment, and palliative care for psychiatric inpatients were insufficient/difficult. 41.9%-57.4% of respondents perceived that social services in the community were insufficient. CONCLUSIONS: This study clarified the level of insufficiency/difficulty perceived by psychiatric care providers regarding issues related to cancer care for people with mental illness. Psychiatric care providers are required to have knowledge and skills in cancer screening and treatment. To improve access to cancer prevention, treatment, and palliative care, it may be helpful to establish systems to promote coordination between cancer hospitals and psychiatric hospitals.

  20. Effect of social participation on the association between frailty and disability. 国際誌

    Toshimasa Sone, Naoki Nakaya, Yumi Sugawara, Sanae Matsuyama, Ichiro Tsuji

    Archives of gerontology and geriatrics 110 104989-104989 2023年7月

    DOI: 10.1016/j.archger.2023.104989  

    詳細を見る 詳細を閉じる

    OBJECTIVES: To examine whether social participation affects the association between frailty and disability. METHODS: A baseline survey conducted from December 1 to 15, 2006, included 11,992 participants who were classified based on the Kihon Checklist into three categories and based on the number of activities in which they socially participated into four categories. The study outcome, incident functional disability, was defined as in Long-Term Care Insurance certification. A Cox proportional hazards model was used to calculate hazard ratios (HRs) for incident functional disability according to frailty and social participation categories. Combination analysis was performed between the nine groups using the above-mentioned Cox proportional hazards model. RESULTS: During the 13-year follow-up (107,170 person-years), 5,732 incident cases of functional disability were certified. Compared with the robust group, the other groups had significantly higher incident functional disability. However, the HRs for those participating in social activities were lower than that for those not participating in any activity [1.52 (pre-frail + none group); 1.31 (pre-frail + one activity group); 1.42 (pre-frail + two activities group); 1.37 (pre-frail + three activities group); 2.35 (frail + none group); 1.87 (frail + one activity group); 1.85 (frail + two activities group); and 1.71 (frail + three activities group)]. CONCLUSIONS: The risk of functional disability for those participating in social activities was lower than that for those not participating in any activity, irrespective of being pre-frail or frail. Comprehensive social systems for disability prevention need to focus on social participation in frail older adults.

  21. Characteristics of disorders of gut-brain interaction in the Japanese population in the Rome Foundation Global Epidemiological Study. 国際誌

    Shin Fukudo, Kumi Nakaya, Tomohiko Muratsubaki, Naoki Nakaya, Atsushi Hozawa, Shrikant I Bangdiwala, Olafur S Palsson, Ami D Sperber, Motoyori Kanazawa

    Neurogastroenterology and motility 35 (6) e14581 2023年6月

    DOI: 10.1111/nmo.14581  

    詳細を見る 詳細を閉じる

    BACKGROUND: The aims were to use Japanese data from the Rome Foundation Global Epidemiological Study (RFGES) to test the hypotheses that severity of gastrointestinal (GI) symptoms and psychosocial disturbance are ordered as Rome IV irritable bowel syndrome (IBS) > Rome III IBS > DGBI, not IBS > others. METHODS: Subjects were 2504 Japanese in the RFGES. We assessed DGBI/IBS diagnoses with Rome IV/III, IBS Symptom Severity Scale (IBS-SSS), Patient Health Questionnaire (PHQ) for anxiety/depression and non-GI somatic symptoms, PROMIS-10 for quality of life (QOL), Work Productivity and Activity Impairment (WPAI) Questionnaire, parts of Self-reported IBS Questionnaire (SIBSQ) for meal effect and stress effect, Food Frequency Questionnaire, and medication questions. KEY RESULTS: The prevalence of Rome IV DGBI was as follows; IBS-C 0.5%, IBS-D 0.8%, IBS-M 0.8%, IBS-U 0.1%, unspecified functional bowel disorder 10.7%, postprandial distress syndrome 2.2%, and epigastric pain syndrome 0.3%. Rome III IBS prevalence; IBS-C 3.0%, IBS-D 3.1%, IBS-M 2.7%, and IBS-U 0.6%. Comparison among Rome IV IBS (n = 54), Rome III IBS (n = 197), other DGBI (n = 746), others (n = 1389) revealed significant order as Rome IV IBS > Rome III IBS > other DGBI > others in IBS-SSS, anxiety/depression, activity impairment, non-GI symptoms, physical QOL, mental QOL, exacerbated symptoms by meals and perceived stress (all p < 0.001). CONCLUSIONS & INFERENCES: These findings support the study hypotheses. Data from Japan as a culturally homogenous country suggest Rome IV IBS is more severe and hence has more gut-brain psychobehavioral involvement than Rome III IBS.

  22. Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort-Results of an International Multicenter Randomized Controlled Trial. 国際誌

    Richard Gearry, Shin Fukudo, Giovanni Barbara, Barbara Kuhn-Sherlock, Juliet Ansell, Paul Blatchford, Sarah Eady, Alison Wallace, Christine Butts, Cesare Cremon, Maria Raffaella Barbaro, Isabella Pagano, Yohei Okawa, Tomohiko Muratubaki, Tomoko Okamoto, Mikiko Fuda, Yuka Endo, Michiko Kano, Motoyori Kanazawa, Naoki Nakaya, Kumi Nakaya, Lynley Drummond

    The American journal of gastroenterology 118 (6) 1058-1068 2023年6月1日

    DOI: 10.14309/ajg.0000000000002124  

    詳細を見る 詳細を閉じる

    INTRODUCTION: Consumption of green kiwifruit is known to relieve constipation. Previous studies have also reported improvements in gastrointestinal (GI) comfort. We investigated the effect of consuming green kiwifruit on GI function and comfort. METHODS: Participants included healthy controls (HC, n = 63), patients with functional constipation (FC, n = 60) and constipation-predominant irritable bowel syndrome (IBS-C, n = 61) randomly assigned to consume two green kiwifruit or psyllium (7.5 g) per day for 4 weeks, followed by a 4-week wash-out, then the other treatment for 4 weeks. The primary outcome was the number of complete spontaneous bowel movements (CSBM) per week. Secondary outcomes of GI comfort, including the gastrointestinal symptom rating scale (GSRS), a validated instrument. Data (intent-to-treat (ITT)) were analysed as difference from baseline using repeated measures analysis of variance suitable for AB/BA cross-over design. RESULTS: Consumption of green kiwifruit was associated with a clinically relevant increase of ≥ 1.5 CSBM per week (FC; 1.53, p<0.0001, IBS-C; 1.73, p=0.0003), and significantly improved measures of GI comfort (GSRS total score) in constipated participants (FC, p<0.0001; IBS-C, p<0.0001). No significant adverse events were observed. DISCUSSION: This study provides original evidence that the consumption of a fresh, whole fruit has demonstrated clinically relevant increases in CSBM and improved measures of GI comfort constipated populations. Green kiwifruit are a suitable dietary treatment for relief of constipation and associated GI comfort.

  23. Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power. 国際誌

    Nanako Shiokawa, Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara, Shin-Ichi Izumi

    Journal of clinical medicine 12 (9) 2023年5月4日

    DOI: 10.3390/jcm12093272  

    詳細を見る 詳細を閉じる

    Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90-8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54-7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings.

  24. 高齢者における尿Na/K比の血圧への影響は非高齢者より大きい

    平田 匠, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 丹野 高三, 寳澤 篤

    日本老年医学会雑誌 60 (Suppl.) 178-178 2023年5月

    出版者・発行元:(一社)日本老年医学会

    ISSN:0300-9173

  25. 抑うつ症状と家庭高血圧発症リスクの関連 東北メディカル・メガバンク計画地域住民コホート調査

    時岡 紗由理, 中谷 直樹, 中谷 久美, 小暮 真奈, 千葉 一平, 畑中 里衣子, 菅野 郁美, 小原 拓, 栗山 進一, 寳澤 篤

    日本循環器病予防学会誌 58 (2) 146-146 2023年5月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  26. 慢性腎臓病発症に対する高血圧と糖尿病の複合効果

    遠山 真弥, 佐藤 倫広, 村上 任尚, 橋本 英明, 中山 晋吾, 小原 拓, 中谷 直樹, 森 建文, 大久保 孝義, 今井 潤, 寳澤 篤, 目時 弘仁

    日本腎臓学会誌 65 (3) 259-259 2023年5月

    出版者・発行元:(一社)日本腎臓学会

    ISSN:0385-2385

    eISSN:1884-0728

  27. Association between the extent of house collapse and urine sodium-to-potassium ratio of victims affected by the 2011 Great East Japan Earthquake and Tsunami: a cross-sectional study. 国際誌

    Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Koichi Asahi, Fumitaka Tanaka, Shinichi Omama, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Atsushi Hozawa, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki

    Hypertension research : official journal of the Japanese Society of Hypertension 46 (5) 1247-1256 2023年5月

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41440-023-01190-5  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    Abstract People who experience natural disasters have a high risk of developing cardiovascular diseases. We investigated the association between the extent of house collapse and urine sodium-to-potassium (UNa/K) ratio of 2011 Great East Japan Earthquake victims. We used the baseline survey data of the Tohoku Medical Megabank Project Community-Based Cohort Study of 29 542 individuals (aged 20–74 years) residing in the affected areas. The UNa/K ratio was calculated using spot urinary electrolyte values. Analysis of covariance was used to calculate the multivariate-adjusted geometric means of the UNa/K ratio in the following groups stratified according to the self-reported extent of house collapse: total collapse (TC), half collapse (HC), partial collapse (PC), and no damage (ND). Multivariable-adjusted odds ratios (ORs) for a high UNa/K ratio were calculated using logistic regression. The TC, HC, PC, and ND groups comprised 5 359 (18.1%), 3 576 (12.1%), 7 331 (24.8%), and 13 276 (44.9%) participants, respectively. The TC (3.33; 95% confidence interval [CI], 3.28–3.38), HC (3.37; 3.30–3.43), and PC (3.32; 3.28–3.37) groups had significantly higher multivariate-adjusted geometric means of the UNa/K ratio than the ND (3.24; 3.21–3.27) group. The multivariable-adjusted ORs (95% CIs) for a high UNa/K ratio in the TC, HC, and PC groups vs. the ND group were 1.07 (0.99–1.15), 1.20 (1.11–1.31), and 1.20 (1.12–1.28), respectively. Similar associations between house collapse and UNa/K ratio were observed for both sexes. We report that victims of a natural disaster tend to have a diet with high sodium-to-potassium ratio.

  28. Smoking history and severe atrophic gastritis assessed by pepsinogen are risk factors for the prevalence of synchronous gastric cancers in patients with gastric endoscopic submucosal dissection: a multicenter prospective cohort study.

    Waku Hatta, Tomoyuki Koike, Sho Asonuma, Hideki Okata, Kaname Uno, Tomoyuki Oikawa, Wataru Iwai, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Motoki Ohyauchi, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Kazuaki Norita, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

    Journal of gastroenterology 58 (5) 433-443 2023年5月

    DOI: 10.1007/s00535-023-01967-y  

    詳細を見る 詳細を閉じる

    BACKGROUND: No studies have evaluated the relationship between lifestyle and synchronous gastric cancers (SGCs) in patients with endoscopic submucosal dissection (ESD) for early gastric cancers (EGCs). Using data from the Tohoku gastrointestinal (GI) study, we aimed to identify factors associated with SGCs. METHODS: Tohoku GI study is a multicenter prospective cohort study investigating the relationship between lifestyle and metachronous gastric cancers. Patients who had a schedule to undergo ESD for primary EGCs were enrolled. We used logistic regression analysis to examine the relationship of 15 candidate factors, including lifestyle, with the prevalence of SGCs in this study. RESULTS: Of 850 patients between 2016 and 2019, 16.0% (136 patients) had SGCs. In multivariate analysis, smoking history (odds ratio [OR], 1.93; p = 0.048) and severe atrophic gastritis assessed by pepsinogen (OR, 1.92; p = 0.004) were risk factors for the prevalence of SGCs. Regarding smoking, current smoking (OR, 2.33; p = 0.021), but not former smoking (OR, 1.76; p = 0.098), was a significant risk factor for its prevalence. In the stratified analysis, severe atrophic gastritis assessed by pepsinogen was a risk factor in patients without Helicobacter pylori (H. pylori) eradication (OR, 2.10; p = 0.002), but not a risk factor in those with H. pylori eradication (OR, 0.75; p = 0.737). CONCLUSION: Smoking history was a risk factor for the prevalence of SGCs in patients with ESD for EGCs, and severe atrophic gastritis assessed by pepsinogen was also a risk factor when H. pylori was not eradicated.

  29. Prognostic Benefit of Additional Treatment After Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma. 国際誌

    So Takahashi, Waku Hatta, Kenta Watanabe, Tomoyuki Koike, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Ippei Tanaka, Yusuke Onozato, Koichi Hamada, Daisuke Fukushi, Ko Watanabe, Shoichi Kayaba, Hirotaka Ito, Tatsuya Mikami, Tomoyuki Oikawa, Yasushi Takahashi, Yutaka Kondo, Tetsuro Yoshimura, Takeharu Shiroki, Ko Nagino, Norihiro Hanabata, Akira Funakubo, Dai Hirasawa, Tetsuya Ohira, Jun Nakamura, Tomohiro Nakamura, Naoki Nakaya, Takayuki Matsumoto, Shinsaku Fukuda, Atsushi Masamune, Katsunori Iijima

    Digestive diseases and sciences 68 (5) 2050-2060 2023年5月

    DOI: 10.1007/s10620-022-07746-8  

    詳細を見る 詳細を閉じる

    BACKGROUND: Although additional treatment is considered for patients with esophageal squamous cell carcinoma (ESCC) invading into the muscularis mucosa (pT1a-MM) or submucosa (pT1b-SM) after endoscopic submucosal dissection (ESD), the actual benefits of this method remain to be elucidated. AIMS: We aimed to evaluate the prognostic benefits of additional treatment in such patients. METHODS: Between 2006 and 2017, we enrolled patients with pT1a-MM/pT1b-SM ESCC after ESD at 21 institutions in Japan. Overall survival (OS) and disease-specific survival (DSS) were compared between the additional treatment and follow-up groups after propensity score matching, to reduce the bias of baseline characteristics. A subgroup analysis was performed according to the pathological findings: category A, pT1a-MM but negative for lymphovascular invasion (LVI) and vertical margin (VM); category B, tumor invasion into the submucosa ≤ 200 μm but negative for LVI and VM; category C, others. RESULTS: Of 593 patients with pT1a-MM/pT1b-SM ESCC after ESD, 101 matched pairs were extracted after propensity score matching. The OSs were similar between the additional treatment and follow-up groups (80.6% vs. 78.6% in 5 years; P = 0.972). In a subgroup analysis, the OS in the additional treatment group was significantly lower than that in the follow-up group (65.7% vs. 95.2% in 5 years; P = 0.037) in category A, whereas OS did not significantly differ in category C (76.8% vs. 69.5% in 5 years; P = 0.360). CONCLUSIONS: Additional treatment after ESD in patients with pT1a-MM/pT1b-SM ESCC was not associated with an improved prognosis.

  30. 10年間のコホート調査に基づく東日本大震災被災者における心理的苦痛の経年変化 査読有り

    臼倉 瞳, 内海 裕介, 瀬戸 萌, 佐久間 篤, 菅原 由美, 國井 泰人, 中谷 直樹, 寳澤 篤, 辻 一郎, 富田 博秋

    精神神経学雑誌 125 (4) 266-274 2023年4月25日

    DOI: 10.57369/pnj.23-039  

  31. White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease. 国際誌

    Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Kimihiko Kaneko, Toshiyuki Takahashi, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

    Scientific reports 13 (1) 6481-6481 2023年4月20日

    DOI: 10.1038/s41598-023-33827-3  

    詳細を見る 詳細を閉じる

    White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p < 0.0001), monocyte count (p = 0.0191), MLR (p = 0.0320), and NLR (p = 0.0002) than those of MOGAD-matched volunteers (n = 130). The three demyelinating diseases showed similar levels of the total and differential WBC counts; however, MOGAD and MS showed different structures in the hierarchical clustering and distributions on a two-dimensional canonical plot using differential WBC counts from the other three groups. WBC count profiles were similar in patients with MOGAD and MS but differed from profiles in matched volunteers or patients with AQP4-NMOSD.

  32. Combined fat mass and fat-free mass indices and lung function among Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of epidemiology 2023年4月8日

    DOI: 10.2188/jea.JE20220355  

    詳細を見る 詳細を閉じる

    BACKGROUND: Although fat mass index (FMI) and fat-free mass index (FFMI) affect lung function, FMI and FFMI are not independent of each other since FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. We aimed to examine the association of combined FMI and FFMI with lung function. METHODS: In this cross-sectional study, lung function was evaluated using forced expiratory volume at 1 s and forced vital capacity was measured using spirometry. Both FMI and FFMI were classified into sex-specific quartiles (16 groups). Analysis of covariance was used to assess the associations of combined FMI and FFMI with lung function. The trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1-4 (lowest-highest), and entering the number as a continuous term in the regression model. RESULTS: This study included 3,736 men and 8,821 women aged ≥20 years living in Miyagi Prefecture, Japan. The mean FEV1 (standard deviation) was 3.0 (0.7) L for men and 2.3 (0.5) L for women. The mean FVC was 3.8 (0.7) L for men and 2.8 (0.5) L for women. The FMI was inversely associated with lung function among all FFMI subgroups in both sexes. Conversely, FFMI was positively associated with lung function in all FMI subgroups in both sexes. CONCLUSIONS: Higher FMI was associated with lower lung function independent of FFMI; higher FFMI was associated with higher lung function independent of FMI. Reducing FMI and maintaining FFMI might be important for respiratory health.

  33. Preventive Effects of Group Cognitive Behavioral Therapy in First-Year University Students at Risk for Depression: A Non-Randomized Controlled Trial. 国際誌

    Sayaka Ogawa, Masaki Hayashida, Jun Tayama, Tatsuo Saigo, Naoki Nakaya, Toshimasa Sone, Masakazu Kobayashi, Peter Bernick, Atsushi Takeoka, Susumu Shirabe

    Perceptual and motor skills 130 (2) 790-807 2023年4月

    DOI: 10.1177/00315125231153778  

    詳細を見る 詳細を閉じる

    High scores on Harm Avoidance (HA) on Cloniger's Temperament and Character Inventory (TCI) have been identified as a risk factor for depression. Group cognitive-behavioral therapy (GCBT) has been found effective in preventing depression and improving depressive symptoms among university students. However, no randomized controlled trials of GCBT have been conducted with university students with high HA. Although we initiated a randomized controlled trial in this study, some participants submitted incomplete questionnaires at baseline interfering with assured randomization; therefore, we report this study as a non-randomized controlled trial. We evaluated whether a GCBT intervention would be effective at reducing HA and, thereby, preventing depression in university students with high HA. We performed final analysis of data on 59 participants in the intervention group and 60 in a control group. We used scores on the Beck Depression Inventory-II (BDI-II) as the primary outcome measure and analysis of covariance to assess group differences on mean BDI-II change scores before the intervention and at six months and one year after the intervention. The intervention group had lower BDI-II scores than the control group at six months after the intervention. GCBT may have facilitated cognitive modification in individuals with high HA, or GCBT may have fostered mutual modeling by group participants. Thus, GCBT may contribute to reducing depressive symptoms in university students with high HA, and associated risk for developing depression.

  34. Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. 国際誌

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of hypertension 41 (3) 443-452 2023年3月1日

    DOI: 10.1097/HJH.0000000000003356  

    詳細を見る 詳細を閉じる

    BACKGROUND: Although several studies have shown an inverse association between lung function and hypertension, few studies have examined the association between lung function and hypertension among never-smokers, and no study has investigated the association between lung function and home hypertension. We investigated the associations between lung function and hypertension in a Japanese population. INDIVIDUALS AND METHODS: We conducted a cross-sectional study of 3728 men and 8795 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was assessed using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC), measured by spirometry. Hypertension was defined as a casual blood pressure at least 140/90 mmHg and/or self-reported treatment for hypertension. Home hypertension was defined as morning home blood pressure at least 135/85 mmHg and/or self-reported treatment for hypertension. Multivariate logistic regression models adjusted for potential confounders were used to assess the association between lung function and hypertension. RESULTS: The mean ages (±SD) of men and women were 60.1 (±14.0) years and 56.2 (±13.4) years, respectively, and 1994 (53.5%) men and 2992 (34.0%) women had hypertension. In the multivariable models, FEV1 and FVC were inversely associated with hypertension. Inverse associations between lung function and hypertension were observed even among never-smokers. Furthermore, reduced lung function was associated with higher prevalence of home hypertension in men and women. CONCLUSION: Reduced lung function was associated with higher prevalence of hypertension, independent of smoking status. Assessment of the lung function or blood pressure may be required in individuals with reduced lung function or hypertension.

  35. Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 30 (3) 255-273 2023年3月1日

    DOI: 10.5551/jat.63523  

    詳細を見る 詳細を閉じる

    AIM: Although many epidemiological studies have shown that obesity assessed by body mass index is associated with carotid intima-media thickness (cIMT), few studies have evaluated fat-free mass, which is a component of body composition. We investigated the associations between the combined fat mass index (FMI) and fat-free mass index (FFMI) with cIMT. METHODS: We conducted a cross-sectional study of 3,873 men and 9,112 women aged 20 years or older who lived in Miyagi prefecture, Japan. The FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. The indices were classified into sex-specific quartiles and were combined into 16 groups. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between the combined FMI and FFMI with cIMT adjusted for age and smoking status. The linear trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1 (lowest) to 4 (highest), and entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher FMI was not related to higher cIMT in men and women in most FFMI subgroups. Conversely, a higher FFMI was related to higher cIMT in all FMI subgroups (p<0.001 for linear trend). CONCLUSIONS: FMI was not associated with cIMT in most FFMI subgroups. Conversely, FFMI was positively associated with cIMT independently of FMI.

  36. Blue light imaging and linked color imaging as a screening mode for esophageal squamous cell carcinoma in high-risk patients: Multicenter randomized trial. 国際誌

    Yohei Ogata, Waku Hatta, Tomoyuki Koike, So Takahashi, Tamotsu Matsuhashi, Tomoyuki Oikawa, Wataru Iwai, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Yu Sasaki, Masashi Kawamura, Masahiro Saito, Kaname Uno, Fumiyoshi Fujishima, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2023年2月18日

    DOI: 10.1111/den.14538  

    詳細を見る 詳細を閉じる

    OBJECTIVES: Blue light imaging (BLI) and linked color imaging (LCI) are superior to conventional white light imaging for detecting esophageal squamous cell carcinoma (ESCC). Hence, we compared their diagnostic performances in ESCC screening. METHODS: This open-labeled, randomized controlled trial was performed at seven hospitals. Patients with a high risk of ESCC were randomly assigned to the BLI group (BLI followed by LCI) and LCI group (LCI followed by BLI). The primary endpoint was the detection rate of ESCC in the primary mode. The main secondary endpoint was its miss rate in the primary mode. RESULTS: In total, 699 patients were enrolled. The detection rate of ESCC did not significantly differ between the BLI and LCI groups [4.0% (14/351) vs. 4.9% (17/348); p = 0.565]; however, the number of patients with ESCC tended to be smaller in the BLI group (19 vs. 30). Notably, the miss rate of ESCC was lower in the BLI group [26.3% (5/19) vs. 63.3% (19/30); p = 0.012] and LCI detected no ESCCs missed by BLI. The sensitivity was higher in BLI (75.0% vs. 47.6%; p = 0.042); on the other hand, the positive predictive value in BLI tended to be lower (28.8% vs. 45.5%; p = 0.092). CONCLUSIONS: The detection rates of ESCC did not significantly differ between BLI and LCI. Although BLI may have a potential to be advantageous over LCI for the diagnosis of ESCC, it is still unclear whether BLI is superior to LCI, and a further large-scale study is needed.

  37. Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 2023年2月11日

    DOI: 10.5551/jat.64039  

    詳細を見る 詳細を閉じる

    AIM: We examined the association between the carotid intima medica thickness (cIMT) and risk factors for atherosclerosis based on the Japan Atherosclerosis Society 2022 Atherosclerosis Prevention Guideline. METHODS: Using data from the Tohoku Medical Megabank Community-based Cohort Study, we performed a cross-sectional study that enrolled 13,366 participants (age ≥ 20 years) with an analysis of covariance to assess associations between cIMT and risk factors for atherosclerosis. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. Analysis was conducted in the model adjusted for age, sex, smoking status, drinking status, body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), high-density lipoprotein-cholesterol (HDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C), and height. RESULTS: In this study cohort, the average age and cIMT were 57.3 (13.8) years and 0.61 (0.13) mm, respectively, which included 3,988 males (29.8%). Males had a higher cIMT than did the females. Age, height, BMI, SBP, HbA1c, and non-HDL-C were positively associated with cIMT. HDL-C was inversely associated with cIMT. Compared with never drinkers, current drinkers (≥ 46.0 g/day) had a significantly decreased cIMT. CONCLUSIONS: The cIMT was associated with atherosclerosis risk factors including age, sex, BMI, SBP, HbA1c, non-HDL-C, and HDL-C, and adequate control of risks in high-risk individuals might be required to prevent atherosclerotic cardiovascular diseases.

  38. 地域在住高齢者の自己報告による視覚障害と要介護発生との関連 鶴ヶ谷プロジェクト

    小幡 紘輝, 鈴鴨 よしみ, 宮武 ミドリ, 永富 良一, 小暮 真奈, 中谷 直樹, 寳澤 篤, 出江 紳一

    Journal of Epidemiology 33 (Suppl.1) 149-149 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  39. 診察室非高血圧者における抑うつ気分と仮面高血圧の関連性の検討

    時岡 紗由理, 中谷 直樹, 千葉 一平, 中谷 久美, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 小原 拓, 栗山 進一, 辻 一郎

    Journal of Epidemiology 33 (Suppl.1) 141-141 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  40. BMI・飲酒・尿Na/K比と高血圧の関連における両親の高血圧既往の影響

    平田 匠, 小暮 真奈, 畑中 里衣子, 千葉 一平, 中谷 久美, 菅野 郁美, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 155-155 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  41. 脂肪量指数と除脂肪量指数の組み合わせと呼吸機能検査指標の関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 155-155 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  42. 糖尿病指標と嗅覚機能の関連

    佐竹 芽久美, 菅野 郁美, 佐藤 守一, 今枝 孝夫, 高梨 昌樹, 早川 和美, 中谷 久美, 千葉 一平, 小暮 真奈, 畑中 里衣子, 斉藤 智, 中村 智洋, 長神 風二, 荻島 創一, 布施 昇男, 麦倉 俊司, 栗山 進一, 中谷 直樹, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 156-156 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  43. 東北メディカル・メガバンク計画地域住民コホート調査(宮城)詳細二次調査の概要

    中谷 久美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 中村 智洋, 小原 拓, 宇留野 晃, 布施 昇男, 辻 一郎, 栗山 進一, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 173-173 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  44. 血清メタボロームと認知機能変化の関連 NILS-LSAの観察結果から

    寳澤 篤, 大塚 礼, 張 シュ, 菱沼 英史, 元池 育子, 三枝 大輔, 中谷 直樹, 小柴 生造, 荒井 秀典

    Journal of Epidemiology 33 (Suppl.1) 87-87 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  45. Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study. 国際誌

    Emi Ishikawa, Yuta Yokoyama, Haruna Chishima, Hidefumi Kasai, Ouki Kuniyoshi, Motonori Kimura, Jun Hakamata, Hideo Nakada, Naoya Suehiro, Naoki Nakaya, Hideo Nakajima, Shinnosuke Ikemura, Ichiro Kawada, Hiroyuki Yasuda, Hideki Terai, Aya Jibiki, Hitoshi Kawazoe, Kenzo Soejima, Hiroshi Muramatsu, Sayo Suzuki, Tomonori Nakamura

    Investigational new drugs 41 (1) 122-133 2023年2月

    DOI: 10.1007/s10637-023-01328-9  

    詳細を見る 詳細を閉じる

    BACKGROUND: Potential novel strategies for adverse event (AE) management of osimertinib therapy, including therapeutic drug monitoring and the use of biomarkers, have not yet been fully investigated. This study aimed to evaluate (1) the relationship between exposure to osimertinib, especially its active metabolites (AZ5104 and AZ7550), and AEs, and (2) the relationship between germline polymorphisms and AEs. METHODS: We conducted a prospective, longitudinal observational study of 53 patients with advanced non-small cell lung cancer receiving osimertinib therapy from February 2019 to April 2022. A population pharmacokinetic model was developed to estimate the area under the serum concentration-time curve from 0 to 24 h (AUC0-24) of osimertinib and its metabolites. Germline polymorphisms were analyzed using TaqMan® SNP genotyping and CycleavePCR® assays. RESULTS: There was a significant association between the AUC0-24 of AZ7550 and grade ≥ 2 paronychia (p = 0.043) or anorexia (p = 0.011) and between that of osimertinib or AZ5104 and grade ≥ 2 diarrhea (p = 0.026 and p = 0.049, respectively). Furthermore, the AUC0-24 of AZ5104 was significantly associated with any grade ≥ 2 AEs (p = 0.046). EGFR rs2293348 and rs4947492 were associated with severe AEs (p = 0.019 and p = 0.050, respectively), and ABCG2 rs2231137 and ABCB1 rs1128503 were associated with grade ≥ 2 AEs (p = 0.008 and p = 0.038, respectively). CONCLUSION: Higher exposures to osimertinib, AZ5104, and AZ7550 and polymorphisms in EGFR, ABCG2, and ABCB1 were related to higher severity of AEs; therefore, monitoring these may be beneficial for osimertinib AE management.

  46. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

    Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

    The Tohoku journal of experimental medicine 259 (2) 93-105 2023年1月20日

    DOI: 10.1620/tjem.2022.J103  

    詳細を見る 詳細を閉じる

    The Tohoku Medical Megabank Project (TMM) has been conducting a birth and three-generation cohort study (the BirThree Cohort Study). We recruited 73,529 pregnant women and their family members for this cohort study, which included 23,143 newborns and 9,459 of their siblings. We designed and are in the process of conducting three-step health assessments for each newborn at approximately ages of 5, 10 and 16. These health assessments are administered at seven community support centers. Trained genome medical research coordinators conduct physical examinations of and collect biological specimens from each participant. The Sendai Children's Health Square has been established as the headquarters for these child health assessments and is utilized to accumulate knowledge that can facilitate the proper practice of child health assessments. We designed all the relevant health assessments facilities to allow parents and their children to participate in the health assessments concomitantly. Our centers serve as places where child participants and their parents can feel at ease as a result of the implementation of safety measures and child hospitality measures. The TMM BirThree Cohort Study is in the process of conducting strategically detailed health assessments and genome analysis, which can facilitate studies concerning the gene-environment interactions relevant to noncommunicable diseases. Through these operations, our study allows for a significant depth of data to be collected in terms of the number of biospecimens under study and the comprehensiveness of both basic and clinical data alongside relevant family information.

  47. Chronic Diseases and Sociodemographic Characteristics Associated With Online Health Information Seeking and Using Social Networking Sites: Nationally Representative Cross-sectional Survey in Japan

    Seigo Mitsutake, Yoshimitsu Takahashi, Aki Otsuki, Jun Umezawa, Akiko Yaguchi-Saito, Junko Saito, Maiko Fujimori, Taichi Shimazu, Maiko Fujimori, Masayo Hayakawa, Satoyo Hosono, Manami Inoue, Yuki Kaji, Kota Katanoda, Aya Kuchiba, Tomohiro Matsuda, Yutaka J. Matsuoka, Miyuki Odawara, Aki Otsuki, Junko Saito, Hirokazu Takahashi, Miyako Takahashi, Yosuke Uchitomi, Jun Umezawa, Otome Watanabe, Akiko Yaguchi-Saito, Itsuro Yoshimi, Taichi Shimazu, Gary L. Kreps, Naomi Sakurai, Takumi Momosaka, Miki Akiyama, Rina Miyawaki, Ryo Okubo, Rie Akamatsu, Yui Kawasaki, Kahori Fujisaki, Hirono Ishikawa, Runa Ogawa, Yoshiharu Fukuda, Haruhiko Imamura, Kumi Nakaya, Naoki Nakaya, Seigo Mitsutake, Hiroyuki Sasai

    Journal of Medical Internet Research 25 2023年

    DOI: 10.2196/44741  

    eISSN:1438-8871

    詳細を見る 詳細を閉じる

    Background: In an aging society, worsening chronic diseases increase the burden on patients and the health care system. Using online health information including health information via social networking sites (SNSs), such as Facebook and YouTube, may play an important role in the self-management of chronic diseases and health promotion for internet users. Objective: This study aims to improve strategies for promoting access to reliable information for the self-management of chronic diseases via the internet, and to identify populations facing barriers to using the internet for health, we examined chronic diseases and characteristics associated with online health information seeking and the use of SNSs. Methods: This study used data from the INFORM Study 2020, which was a nationally representative cross-sectional postal mail survey conducted using a self-administered questionnaire in 2020. The dependent variables were online health information seeking and SNS use. Online health information seeking was assessed using 1 question about whether respondents used the internet to find health or medical information. SNS use was assessed by inquiring about the following 4 aspects: visiting SNSs, sharing health information on SNSs, writing in an online diary or blog, and watching a health-related video on YouTube. The independent variables were 8 chronic diseases. Other independent variables were sex, age, education status, work, marital status, household income, health literacy, and self-reported health status. We conducted a multivariable logistic regression model adjusted for all independent variables to examine the associations of chronic diseases and other variables with online health information seeking and SNS use. Results: The final sample for analysis comprised 2481 internet users. Hypertension or high blood pressure, chronic lung diseases, depression or anxiety disorder, and cancer were reported by 24.5%, 10.1%, 7.7%, and 7.2% of respondents, respectively. The odds ratio of online health information seeking among respondents with cancer was 2.19 (95% CI 1.47-3.27) compared with that among those without cancer, and the odds ratio among those with depression or anxiety disorder was 2.27 (95% CI 1.46-3.53) compared with that among those without. Further, the odds ratio for watching a health-related YouTube video among those with chronic lung diseases was 1.42 (95% CI 1.05-1.93) compared with that among those without these diseases. Women, younger age, higher level of education, and high health literacy were positively associated with online health information seeking and SNS use. Conclusions: For patients with cancer, strategies for promoting access to websites with reliable cancer-related information as well as access among patients with chronic lung diseases to YouTube videos providing reliable information may be beneficial for the management of these diseases. Moreover, it is important to improve the online environment to encourage men, older adults, internet users with lower education levels, and those with low health literacy to access online health information.

  48. 早期胃癌治療後の早期・後期死亡関連因子

    尾形 洋平, 八田 和久, 大原 祐樹, 小池 智幸, 阿部 寛子, 齊藤 真弘, 金 笑奕, 菅野 武, 宇野 要, 浅野 直喜, 今谷 晃, 山村 明寛, 田中 直樹, 亀井 尚, 海野 倫明, 中村 智洋, 中谷 直樹, 正宗 淳

    日本消化器内視鏡学会雑誌 65 (2) 162-172 2023年

    出版者・発行元:一般社団法人 日本消化器内視鏡学会

    DOI: 10.11280/gee.65.162  

    ISSN:0387-1207

    eISSN:1884-5738

    詳細を見る 詳細を閉じる

    【目的】早期胃癌患者の大部分は非胃癌が原因で死亡するが,早期胃癌のリンパ節転移リスクと非胃癌死を含めた全死亡との関連については分かっていない.本研究では,早期死亡と後期死亡の関連因子を明らかにすることを目的とした. 【方法】2003年から2017年に早期胃癌に対し内視鏡的切除,外科切除を施行した患者を後ろ向きに解析した.リンパ節転移リスク,治療法,そのほか9つの非胃癌関連の因子について,3年をカットオフとして早期死亡,後期死亡に分けて関連因子を解析した. 【結果】経過観察期間中央値79カ月で,1,439例が解析された.5年全生存率は86.8%であった.多変量解析で,早期死亡,後期死亡の最も重要な予測因子は,年齢85歳以上[ハザード比(hazard ratio;HR)2.88(早期死亡);4.54(後期死亡)],Eastern Cooperative Oncology Group Performance Status≥2(HR 3.00;4.19)であった.チャールソン併存疾患指数≥2(HR 2.76;1.99),米国麻酔科学会術前身体状態分類≥3(HR 2.35;1.79),CRP/アルブミン比≥0.028(HR 2.30;1.58)も早期死亡,後期死亡の関連因子であった.男性(HR 2.26),eCura systemでみたリンパ節転移中リスク(HR 2.12)と高リスク(HR 1.85),腸腰筋の断面積で評価したサルコペニア(HR 1.70)は早期死亡の関連因子であった. 【結語】様々な予後関連因子の総合的評価は,早期胃癌患者の早期死亡,後期死亡を予測するのに有用な可能性がある.eCura systemは早期死亡に関連していた.

  49. Sex-Specific Differences in the Transcriptome of the Human Dorsolateral Prefrontal Cortex in Schizophrenia. 国際誌

    Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomita

    Molecular neurobiology 60 (2) 1083-1098 2022年11月22日

    DOI: 10.1007/s12035-022-03109-6  

    詳細を見る 詳細を閉じる

    Schizophrenia presents clinical and biological differences between males and females. This study investigated transcriptional profiles in the dorsolateral prefrontal cortex (DLPFC) using postmortem data from the largest RNA-sequencing (RNA-seq) database on schizophrenic cases and controls. Data for 154 male and 113 female controls and 160 male and 93 female schizophrenic cases were obtained from the CommonMind Consortium. In the RNA-seq database, the principal component analysis showed that sex effects were small in schizophrenia. After we analyzed the impact of sex-specific differences on gene expression, the female group showed more significantly changed genes compared with the male group. Based on the gene ontology analysis, the female sex-specific genes that changed were overrepresented in the mitochondrion, ATP (phosphocreatine and adenosine triphosphate)-, and metal ion-binding relevant biological processes. An ingenuity pathway analysis revealed that the differentially expressed genes related to schizophrenia in the female group were involved in midbrain dopaminergic and γ-aminobutyric acid (GABA)-ergic neurons and microglia. We used methylated DNA-binding domain-sequencing analyses and microarray to investigate the DNA methylation that potentially impacts the sex differences in gene transcription using a maternal immune activation (MIA) murine model. Among the sex-specific positional genes related to schizophrenia in the PFC of female offspring from MIA, the changes in the methylation and transcriptional expression of loci ACSBG1 were validated in the females with schizophrenia in independent postmortem samples by real-time PCR and pyrosequencing. Our results reveal potential genetic risks in the DLPFC for the sex-dependent prevalence and symptomology of schizophrenia.

  50. The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 2022年11月4日

    DOI: 10.5551/jat.63826  

    詳細を見る 詳細を閉じる

    AIM: Impaired lung function is associated with atherosclerotic vascular events. Carotid intima-media thickness (cIMT) is a marker for subclinical atherosclerosis. However, few studies have examined the association between lung function and cIMT among never smokers or individuals stratified by age. We investigated the association between lung function and cIMT in the Japanese population. METHODS: We conducted a cross-sectional study of 3,716 men and 8,765 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was evaluated using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) was measured using spirometry. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between lung function and cIMT and adjusted for potential confounders. A linear trend test was conducted by scoring the categories from 1 (lowest) to 4 (highest) and entering the score as a continuous term in the regression model. RESULTS: After adjusting for potential confounders including passive smoking, lower FEV1 and FVC were associated with higher cIMT in both men and women (P<0.001 for linear trend). This association was confirmed even when we restricted our study to never smokers. Furthermore, even when we stratified by age, an inverse association between lung function and cIMT was confirmed in middle-aged (40-64 years) and elderly participants (65-74 years). CONCLUSIONS: Lower lung function was associated with higher cIMT in the Japanese population independent of age and smoking. Assessment of atherosclerosis or lung function may be required for individuals with lower lung function or atherosclerosis.

  51. Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan. 国際誌

    Naoki Nakaya, Kumi Nakaya, Naho Tsuchiya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ikumi Kanno, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Shinichi Kuriyama

    BMC public health 22 (1) 1978-1978 2022年10月28日

    DOI: 10.1186/s12889-022-14348-6  

    詳細を見る 詳細を閉じる

    BACKGROUND: Previous observational studies have shown similarities in cardiometabolic risk factors between spouses. It is still possible that this result reflects the age similarity of spouses rather than environmental factors of spouses (e.g. cohabitation effect). To clarify the importance of mate cardiometabolic risk factors for similarity of environmental factors, it is necessary to examine whether they are observed in random male-female pairs while maintaining the age of the spousal pairs. This study aimed to determine whether the similarities found between spousal pairs for cardiometabolic risks were also observed between random male-female pairs. METHODS: This cross-sectional study included 5,391 spouse pairs from Japan; data were obtained from a large biobank study. For pairings, women of the same age were randomly shuffled to create new male-female pairs of the same age as that of the original spouse pairs. Similarities in cardiometabolic risk factors between the random male-female pairs were analysed using Pearson's correlation or age-adjusted logistic regression analyses. RESULTS: The mean ages of the men and women were 63.2 and 60.4 years, respectively. Almost all cardiometabolic risk factors similarities were not noted in cardiometabolic risk factors, including the continuous risk factors (anthropometric traits, blood pressure, glycated haemoglobin level, and lipid traits); lifestyle habits (smoking, drinking, and physical activity); or diseases (hypertension, type 2 diabetes mellitus, and metabolic syndrome) between the random male-female pairs. The age-adjusted correlation coefficients ranged from - 0.007 for body mass index to 0.071 for total cholesterol. The age-adjusted odds ratio (95% confidence interval) for current drinkers was 0.94 (0.81 - 1.09); hypertension, 1.07 (0.93 - 1.23); and type 2 diabetes mellitus, 1.08 (0.77 - 1.50). CONCLUSION: In this study, few similarities in cardiometabolic risk factors were noted among the random male-female pairs. As spouse pairs may share environmental factors, intervention strategies targeting lifestyle habits and preventing lifestyle-related diseases may be effective.

  52. Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma.

    Shusuke Toda, Waku Hatta, Kiyotaka Asanuma, Naoki Asano, Yoshitaka Ono, Hiroko Abe, Yohei Ogata, Masahiro Saito, Takeshi Kanno, Xiaoyi Jin, Kaname Uno, Tomoyuki Koike, Akira Imatani, Shin Hamada, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

    The Tohoku journal of experimental medicine 258 (3) 195-206 2022年10月25日

    出版者・発行元:Tohoku University Medical Press

    DOI: 10.1620/tjem.2022.J077  

    ISSN:0040-8727

    eISSN:1349-3329

    詳細を見る 詳細を閉じる

    Patients with esophageal squamous cell carcinoma (ESCC) might have a specific mechanism for the carcinogenesis by alcohol consumption in the background esophageal mucosa, and nuclear factor erythroid 2-related factor 2 (NRF2), which plays a protective role against esophageal carcinogenesis, and barrier dysfunction might be associated with this phenomenon. This study aimed to confirm this hypothesis. Twenty patients with superficial ESCCs (ESCC patients) and 20 age- and sex-matched patients without ESCC (non-ESCC patients) were enrolled. Biopsy samples were obtained from non-neoplastic esophageal mucosa: one for histological evaluation, one for quantitative real-time polymerase chain reaction (PCR), and two for the mini-Ussing chamber system to measure transepithelial electrical resistance (TEER) and, thereafter, for PCR. The TEER after acetaldehyde or both acetaldehyde and ethanol exposure did not differ significantly between ESCC and non-ESCC patients. Unlike non-ESCC patients, mRNA levels of NRF2 target genes and claudin4 in ESCC patients tended to decrease after the exposure, with a significant difference between no exposure and both acetaldehyde and ethanol exposure in NRF2 target genes (p < 0.05). Furthermore, in ESCC patients, the decreased tendency of mRNA levels of NRF2 target genes after the exposure was more pronounced in high-risk states, such as aldehyde dehydrogenase 2 (ALDH2) Lys alleles (Glu/Lys + Lys/Lys), Lugol-voiding lesion grade C, and drinking history. In conclusion, the protective role of NRF2 against carcinogenesis from alcohol exposure might be disrupted in the background esophageal mucosa of ESCC patients, which might lead to a high incidence of metachronous ESCC.

  53. Visualization of estimated prevalence of CES-D positivity accounting for background factors and AIS scores. 国際誌

    Takashi Matsuyama, Akira Narita, Masaki Takanashi, Mana Kogure, Shuichi Sato, Tomohiro Nakamura, Hideo Nakane, Soichi Ogishima, Fuji Nagami, Naoki Nakaya, Kozo Tanno, Takao Imaeda, Atsushi Hozawa

    Scientific reports 12 (1) 17656-17656 2022年10月21日

    DOI: 10.1038/s41598-022-22266-1  

    詳細を見る 詳細を閉じる

    Development of methods for population screening is necessary to improve the efficiency of secondary prevention of diseases. Until now, a common cutoff has been used for all people in the data set. However, if big data for health information can be used to modify individual cutoffs according to background factors, it may avoid wasting medical resources. Here we show that the estimated prevalence of the Center for Epidemiologic Studies Depression Scale positivity can be visualized by a heatmap using background factors from epidemiological big data and scores from the Athens Insomnia Scale. We also show that cutoffs based on the estimated prevalence can be used to decrease the number of people screened without decreasing the number of prevalent cases detected. Since this method can be applied to the screening of different outcomes, we believe our work can contribute to the development of efficient screening methods for various diseases.

  54. 地域在住高齢者の予測努力肺活量と肺炎死の関連および筋力と血清総コレステロール値の影響

    汐川 菜々子, 岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 海老原 覚, 小暮 真奈, 中谷 直樹, 寳澤 篤, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine 59 (秋季特別号) S444-S444 2022年10月

    出版者・発行元:(公社)日本リハビリテーション医学会

    ISSN:1881-3526

    eISSN:1881-8560

  55. Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing. 国際誌

    Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Disaster medicine and public health preparedness 16 (5) 1966-1974 2022年10月

    DOI: 10.1017/dmp.2021.214  

    詳細を見る 詳細を閉じる

    OBJECTIVE: This study aims to evaluate the long-term impact of living in postdisaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held 5 y after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on 5 types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants 5 y after the disaster. CONCLUSIONS: Living in postdisaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities 5 y later.

  56. Development of a method for walking step observation based on large-scale GPS data. 国際誌

    Shohei Nagata, Tomoki Nakaya, Tomoya Hanibuchi, Naoki Nakaya, Atsushi Hozawa

    International journal of health geographics 21 (1) 10-10 2022年9月7日

    DOI: 10.1186/s12942-022-00312-5  

    詳細を見る 詳細を閉じる

    BACKGROUND: Widespread use of smartphones has enabled the continuous monitoring of people's movements and physical activity. Linking global positioning systems (GPS) data obtained via smartphone applications to physical activity data may allow for large-scale and retrospective evaluation of where and how much physical activity has increased or decreased due to environmental, social, or individual changes caused by policy interventions, disasters, and infectious disease outbreaks. However, little attention has been paid to the use of large-scale commercial GPS data for physical activity research due to limitations in data specifications, including limited personal attribute and physical activity information. Using GPS logs with step counts measured by a smartphone application, we developed a simple method for daily walking step estimation based on large-scale GPS data. METHODS: The samples of this study were users whose GPS logs were obtained in Sendai City, Miyagi Prefecture, Japan, during October 2019 (37,460 users, 36,059,000 logs), and some logs included information on daily step counts (731 users, 450,307 logs). The relationship between land use exposure and daily step counts in the activity space was modeled using the small-scale GPS logs with daily step counts. Furthermore, we visualized the geographic distribution of estimated step counts using a large set of GPS logs with no step count information. RESULTS: The estimated model showed positive relationships between visiting high-rise buildings, parks and public spaces, and railway areas and step counts, and negative relationships between low-rise buildings and factory areas and daily step counts. The estimated daily step counts tended to be higher in urban areas than in suburban areas. Decreased step counts were mitigated in areas close to train stations. In addition, a clear temporal drop in step counts was observed in the suburbs during heavy rainfall. CONCLUSIONS: The relationship between land use exposure and step counts observed in this study was consistent with previous findings, suggesting that the assessment of walking steps based on large-scale GPS logs is feasible. The methodology of this study can contribute to future policy interventions and public health measures by enabling the retrospective and large-scale observation of physical activity by walking.

  57. 東日本大震災による自宅の被害状況と高血圧治療中断との関連

    畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中村 智洋, 後岡 広太郎, 小原 拓, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 196-196 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  58. 過敏性腸症候群の有病に関連する要因の検討 TMM計画地域住民コホート調査

    中谷 久美, 中谷 直樹, 永家 聖, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 金澤 素, 荻島 創一, 栗山 進一, 辻 一郎, 寳澤 篤, 福土 審

    日本公衆衛生学会総会抄録集 81回 201-201 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  59. 呼吸機能検査指標と高血圧有病との関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 土屋 菜歩, 平田 匠, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 202-202 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  60. 被災後住居形態と肝機能指標に関する横断研究

    相場 繁, 中谷 直樹, 小暮 真奈, 中谷 久美, 畑中 里衣子, 千葉 一平, 菅野 郁美, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 237-237 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  61. 生活習慣病の既往がない者における食事パターンと受診行動および医療費の関連

    五十嵐 有香, 小暮 真奈, 鈴木 寿則, 畑中 里衣子, 中谷 久美, 菅野 郁美, 千葉 一平, 中村 智洋, 荻島 創一, 中谷 直樹, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 246-246 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  62. 健康診査への尿ナトリウム/カリウム比測定導入から見えてきたことと今後の展開

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 大川 亜美, 黒川 悦子, 永吉 翔, 志賀 利一, 清水 友紀子, 牛田 悠介, 上田 宏幸, 中谷 直樹, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 308-308 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  63. 握力および脚伸展力で測定した各筋力と生理学的データの関連

    野路 慶明, 畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中村 智洋, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 431-431 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  64. 呼吸機能検査指標と高血圧有病との関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 土屋 菜歩, 平田 匠, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 202-202 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  65. Issues of cancer care in people with mental disorders as perceived by cancer care providers: A quantitative questionnaire survey. 国際誌

    Yuto Yamada, Masaki Fujiwara, Tsuyoshi Etoh, Riho Wada, Shinichiro Inoue, Masafumi Kodama, Yusaku Yoshimura, Shigeo Horii, Takanori Matsushita, Maiko Fujimori, Taichi Shimazu, Naoki Nakaya, Shiro Hinotsu, Masahiro Tabata, Kenji Tamura, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Psycho-oncology 31 (9) 1572-1580 2022年9月

    DOI: 10.1002/pon.5992  

    詳細を見る 詳細を閉じる

    OBJECTIVES: To reduce cancer care disparities, this study aimed to clarify the difficulties in cancer care for people with mental disorders as perceived by cancer care providers. METHODS: Cancer care providers at 17 designated cancer hospitals in Japan were surveyed using mail questionnaires. Respondents were asked to rate 29 items related to difficulties or insufficiencies in cancer care for patients with mental disorders on a five-point Likert scale. We analyzed the proportion of respondents who answered 'difficult/insufficient' in each item. We also calculated the proportions of responders stratified according to the presence of psychiatric support systems within their hospitals. RESULTS: A total of 388 (58.4%) cancer care providers responded. Among the issues related to 'difficulties in diagnosing and treating cancer,' support for decision-making, assessment of treatment adherence, and assessment of physical symptoms were perceived as most difficult (73.5%-81.5% of respondents). Among the issues related to 'difficulties or insufficiencies in collaboration among multidisciplinary health care providers,' the issue of advance consultation and sharing information with the patient's primary psychiatric care provider was perceived as most difficult (52.2%). Among the issues related to 'insufficiencies of in-hospital and community medical systems,' education to provide reasonable accommodation was perceived as most insufficient (47.4%). The perceived difficulties of over half of the issues varied significantly between hospitals depending on the level of psychiatric support systems. CONCLUSIONS: This study clarified the difficulties of cancer care in patients with mental disorders as perceived by cancer care providers. Some issues may be resolved by psychiatric liaison teams. This article is protected by copyright. All rights reserved.

  66. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌 (71) 28-28 2022年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  67. Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis. 国際誌

    I Kanno, K Hasegawa, T Nakamura, M Kogure, F Itabashi, A Narita, N Tsuchiya, T Hirata, N Nakaya, J Sugawara, S Kuriyama, I Tsuji, S Kure, A Hozawa

    Public health 208 98-104 2022年7月

    DOI: 10.1016/j.puhe.2022.05.003  

    詳細を見る 詳細を閉じる

    OBJECTIVES: Previous studies have reported the relationship between housing environment and health, although due to cost and effort, it was difficult to conduct housing condition surveys on a large scale. The CASBEE Housing Health Checklist (the Checklist) made it possible to easily evaluate the housing condition from the resident's perspective. This study examined the relationship between housing coldness/warmth evaluation using the Checklist and psychological distress in a large-scale general Japanese population. STUDY DESIGN: A cross-sectional study. METHODS: We analysed data from 29,380 people aged ≥20 years who lived in Miyagi Prefecture, Japan. As an assessment of housing coldness/warmth, we used the Checklist. We classified participants' total scores on the Checklist related to coldness/warmth into quartiles. The Kessler 6 scale was used as an indicator of psychological distress. Multivariable logistic regression models were used to estimate the adjusted odds ratio (OR) and 95% confidence intervals (CIs). Adjusted OR and P-values for linear trends were calculated using the quartiles of the Checklists' score. RESULTS: Among participants in Q1 (i.e., poorer subjective house condition), the percentage of people with psychological distress was high. Compared to the highest quartile, Q1 showed poorer evaluation of housing coldness/warmth, and higher OR for psychological distress. The OR (95% CI) of psychological distress for Q3, Q2, and Q1 compared with Q4 were 1.93 (1.74-2.14), 2.82 (2.55-3.12), and 5.78 (5.25-6.35), respectively. CONCLUSIONS: Housing coldness/warmth evaluation was significantly related to psychological distress. This finding suggests that maintaining a comfortable thermal environment at home could be important for residents' mental health.

  68. Correlation between TXNRD1/HO-1 expression and response to neoadjuvant chemoradiation therapy in patients with esophageal squamous cell carcinoma.

    Ryujiro Akaishi, Fumiyoshi Fujishima, Hirotaka Ishida, Junichi Tsunokake, Takuro Yamauchi, Yusuke Gokon, Shunsuke Ueki, Toshiaki Fukutomi, Hiroshi Okamoto, Kai Takaya, Chiaki Sato, Yusuke Taniyama, Tomohiro Nakamura, Naoki Nakaya, Takashi Kamei, Hironobu Sasano

    Esophagus : official journal of the Japan Esophageal Society 19 (3) 436-443 2022年7月

    DOI: 10.1007/s10388-021-00904-3  

    詳細を見る 詳細を閉じる

    BACKGROUND: Thioredoxin reductase 1 (TXNRD1) and heme oxygenase-1 (HO-1) are both involved in the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and play key roles in antioxidant responses. In patients with esophageal squamous cell carcinoma (ESCC), the correlation between the expression of these two proteins and the therapeutic response to neoadjuvant chemoradiation therapy (NACRT), as well as the difference in their expression after chemoradiotherapy, remains unknown. METHODS: Proteins involved in the Nrf2 pathway were immunolocalized in carcinoma cells in ESCC patients on NACRT with 5-fluorouracil and cisplatin, followed by esophagectomy. The 8-hydroxydeoxyguanosine (8-OHdG) levels were used to quantify reactive oxygen species. The changes in immunoreactivity before and after NACRT (Δ) were assessed. RESULTS: Tumor reduction following NACRT was significantly attenuated in pre-therapeutic biopsy specimens associated with high HO-1 status. TXNRD1Δ, HO-1Δ, and 8-OHdGΔ were significantly different in the ineffective and effective groups. The overall survival was significantly lower in high Nrf2 and TXNRD1 groups. In addition, high TXNRD1 expression was an independent prognostic factor in the multivariate analysis of overall survival. CONCLUSIONS: The study findings indicate that HO-1 status in pre-therapeutic biopsy specimens could predict response to NACRT, and TXNRD1 status could predict overall survival of ESCC patients.

  69. Patients' acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualitative secondary analysis of a mixed-method randomised clinical trial. 国際誌

    Yuto Yamada, Masaki Fujiwara, Taichi Shimazu, Tsuyoshi Etoh, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    BMJ open 12 (6) e060621 2022年6月14日

    DOI: 10.1136/bmjopen-2021-060621  

    詳細を見る 詳細を閉じる

    OBJECTIVES: We examined the efficacy of case management (CM) interventions to encourage participation in colorectal cancer screening for patients with schizophrenia. This study aimed to clarify patients' acceptability of the intervention and the helpful components of the intervention. Simultaneously, the study aimed to determine the acceptability, appropriateness and feasibility of the intervention from the perspective of psychiatric care providers. STUDY DESIGN AND SETTING: This study was a secondary qualitative analysis of a mixed-method randomised controlled trial that evaluated the efficacy of the CM approach to encourage participation in cancer screening for people with schizophrenia. The intervention comprised education and patient navigation for colorectal cancer screening. Interviews were conducted with patients who received the intervention and staff from two psychiatric hospitals in Japan who delivered the intervention. PARTICIPANTS: Of the 172 patients with schizophrenia who participated in the trial, 153 were included. In addition, three out of six providers were included. DATA COLLECTION AND ANALYSIS: Using a structured interview, the case manager asked participants about patient acceptability and the helpful components of the intervention. Content analysis was conducted for the responses obtained, and the number of responses was tabulated by two researchers. For the interviews with the providers, opinions obtained from verbatim transcripts were extracted and summarised. RESULTS: Forty-three of the 56 patients perceived that the intervention was acceptable. For the intervention component, inperson counselling with an explanation of the screening process by psychiatric care providers was most frequently reported by the patients as helpful (48 of the 68 respondents). Psychiatric care providers evaluated the intervention as acceptable, appropriate and easy to understand and administer. However, providing the intervention to all patients simultaneously was considered difficult with the current human resources. CONCLUSIONS: This study showed that the CM intervention was perceived as acceptable by patients and acceptable and appropriate by psychiatric care providers. TRIAL REGISTRATION NUMBER: UMIN000036017.

  70. Review of Mental Health Consequences of the Great East Japan Earthquake through Long-Term Epidemiological Studies: The Shichigahama Health Promotion Project.

    Yasuto Kunii, Hitomi Usukura, Yusuke Utsumi, Moe Seto, Yumiko Hamaie, Yumi Sugawara, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    The Tohoku journal of experimental medicine 257 (2) 85-95 2022年6月4日

    DOI: 10.1620/tjem.2022.J039  

    詳細を見る 詳細を閉じる

    After the Great East Japan Earthquake, Tohoku University began to provide mental health services during the acute phase of the disaster in cooperation with Shichigahama Town, one of the municipalities located in the coastal area of the Miyagi Prefecture that was severely damaged by the earthquake and tsunami; it continued to be providing long-term mental health activities, incorporating annual surveys for affected residents in the town for 10 years. Ten years of combination of surveys and outreach activities first depicted detailed longitudinal alterations in the mental health conditions of communities affected by a catastrophe. While posttraumatic stress reaction had recovered year by year after the year following the Great East Japan Earthquake, recovery from psychological distress retreated between 2014 and 2017, probably due to the relocation from temporal to eternal housing conditions. The annual cycles of assessment and provision of mental health support and promotion activities continued for 10 years can be an initial model for evidence-based, long-term post-disaster mental health and psychosocial support for the affected communities. Data regarding subsequent disasters should be collected in comparable ways, in order to improve the accuracy and usefulness of the accumulated data for planning and providing evidence-based post-disaster mental health and psychosocial support.

  71. Development and validation of a new liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of afatinib, dacomitinib, osimertinib, and the active metabolites of osimertinib in human serum. 国際誌

    Emi Ishikawa, Yuta Yokoyama, Haruna Chishima, Ouki Kuniyoshi, Itaru Sato, Naoki Nakaya, Hideo Nakajima, Motonori Kimura, Jun Hakamata, Naoya Suehiro, Hideo Nakada, Shinnosuke Ikemura, Aya Jibiki, Hitoshi Kawazoe, Hiroshi Muramatsu, Sayo Suzuki, Tomonori Nakamura

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 1199 123245-123245 2022年5月30日

    DOI: 10.1016/j.jchromb.2022.123245  

    詳細を見る 詳細を閉じる

    Reports on the therapeutic drug monitoring (TDM) of second- and third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer patients are limited and are required to improve the safety of EGFR-TKI therapy. Some EGFR-TKIs have active metabolites with similar or higher potency compared with the parent compounds; thus, monitoring the parent compound as well as its active metabolites is essential for truly effective TDM. In this study, we developed and validated a method that simultaneously quantifies second- and third-generation EGFR-TKIs (afatinib, dacomitinib, and osimertinib) and the active metabolites of osimertinib, AZ5104 and AZ7550, in the human serum using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The clinical application of the method was also evaluated. The analytes were extracted from a 100 μL serum sample using a simple protein precipitation method and analyzed using LC-MS/MS. Excellent linearity of calibration curves was observed at ranges of 2.5-125.0 ng/mL for afatinib, 2.5-125.0 ng/mL for dacomitinib, 4.0-800.0 ng/mL for osimertinib, 1.0-125.0 ng/mL for AZ5104, and 2.5-125.0 ng/mL for AZ7550. The precision and accuracy were below 14.9% and within ± 14.9% of the nominal concentrations, respectively. The mean recovery was higher than 94.7% and the coefficient of variation (CV) was lower than 8.3%. The mean internal-standard normalized matrix factors ranged from 94.6 to 111.9%, and the CVs were lower than 9.7%. This analytical method met the acceptance criteria of the U.S. Food and Drug Administration guidelines. The method was also successfully applied to the analysis of 45 clinical samples; it supports the efficient and valuable analysis for TDM investigations of EGFR-TKIs.

  72. Combined Associations of Liver Enzymes and Obesity With Diabetes Mellitus Prevalence: The Tohoku Medical Megabank Community-based Cohort Study.

    Fumi Itabashi, Takumi Hirata, Mana Kogure, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Naoki Nakaya, Ryohei Sasaki, Nobuyuki Takanashi, Kiyomi Sakata, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of epidemiology 32 (5) 221-227 2022年5月5日

    DOI: 10.2188/jea.JE20200384  

    詳細を見る 詳細を閉じる

    BACKGROUND: Alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) are enzymes associated with diabetes mellitus (DM) prevalence. However, limited information is available regarding the association of liver enzymes and DM consistently present in obese and non-obese individuals. We examined whether the combination of ALT and GGT enzymes is associated with the prevalence of DM regardless of obesity in a general Japanese population. METHODS: We conducted a cross-sectional study of 62,786 participants aged ≥20 years who lived in Miyagi and Iwate, Japan. We divided all the participants into eight groups according to the ALT level (low: <30 IU/L and high: ≥30 IU/L), GGT level (low: <50 IU/L and high: ≥50 IU/L), and the presence of obesity. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression analysis, adjusting for potential confounders, to determine associations of the combination of ALT and GGT levels and obesity with DM prevalence. RESULTS: Overall, 6,008 participants (9.6%) had DM. Compared to non-obese individuals with low ALT and GGT levels, the participants with high ALT and GGT levels had high ORs for DM in both obese (OR 4.06; 95% CI, 3.61-4.56) and non-obese groups (OR 2.19; 95% CI, 1.89-2.52). The obese group had high ORs for DM, even at low ALT and GGT levels. CONCLUSION: High ALT and GGT levels are associated with DM prevalence in obese and non-obese participants. This finding suggests that correcting ALT and GGT levels and controlling obesity are important for the prevention of DM.

  73. Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study. 国際誌

    Tomoko Muroya, Michihiro Satoh, Takahisa Murakami, Shingo Nakayama, Kei Asayama, Takuo Hirose, Yukako Tatsumi, Ryusuke Inoue, Megumi Tsubota-Utsugi, Azusa Hara, Mana Kogure, Naoki Nakaya, Kyoko Nomura, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Atsushi Hozawa, Takayoshi Ohkubo

    Journal of hypertension 40 (5) 862-869 2022年5月1日

    DOI: 10.1097/HJH.0000000000003087  

    詳細を見る 詳細を閉じる

    OBJECTIVE: No studies have demonstrated the association between urinary sodium-to-potassium (Na/K) ratio and all out-of-office blood pressure (BP) [home morning and evening BP (self-measured at home), and 24-h, daytime, and night-time ambulatory BP] in the same cohort. We aimed to assess, which type of out-of-office BP is more strongly associated with urinary Na/K ratio in the general population. METHODS: This cross-sectional study was conducted in the general population of Ohasama, Japan. Home and ambulatory BP levels were measured, and 24-h urine samples were obtained from 875 participants (men, 25.5%; mean age, 60.1 years). The urinary Na/K ratio in the 24-h urine samples was calculated. RESULTS: The median (interquartile range) urinary Na/K ratio was 4.19 (3.36-5.26). Significant positive trends of home morning, home evening, 24-h, and daytime SBP were observed across quartiles of urinary Na/K ratio (trend P ≤ 0.041; adjusted mean values between Q1 and Q4 of urinary Na/K ratio: 121.0-125.5 mmHg for home morning, 120.1-123.8 mmHg for home evening, 121.6-123.4 mmHg for 24-h, 127.5-129.5 mmHg for daytime). Urinary Na/K ratio was not significantly associated with office or night-time SBP and nocturnal BP fall (trend P ≥ 0.13). In the model with both home morning or evening SBP and daytime SBP, only home SBP was significantly associated with urinary Na/K ratio (P ≤ 0.048 for home SBP). CONCLUSION: These findings suggest that urinary Na/K ratio might be more strongly associated with home BP than with 24-h and daytime BP but was not associated with night-time BP.

  74. Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study. 国際誌

    Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Kotaro Nochioka, Akira Narita, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Taku Obara, Michihiro Satoh, Hirohito Metoki, Ken Miyagawa, Hiroshi Koshimizu, Sho Nagayoshi, Akira Uruno, Masahiro Kikuya, Kichiya Suzuki, Naoki Nakaya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 45 (5) 866-875 2022年5月

    DOI: 10.1038/s41440-021-00843-7  

    詳細を見る 詳細を閉じる

    The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) ratio is known to have diurnal and day-to-day variations. Therefore, we investigated the number of days required to yield a better association between the morning uNa/K ratio and home BP (HBP) and determined a morning uNa/K ratio value that can be used as a reference value in participants who are not taking antihypertensive medication. This was a cross-sectional study using data from the Tohoku Medical Megabank Project Cohort Study. A total of 3122 participants borrowed HBP and uNa/K ratio monitors for 10 consecutive days. We assessed the relationship between the morning uNa/K ratio from 1 day to 10 days and home hypertension (HBP ≥ 135/85 mmHg) using multiple logistic regression models. Although a 1-day measurement of the morning uNa/K ratio was positively associated with home hypertension, multiple measurements of the morning uNa/K ratio were strongly related to home hypertension. The average morning uNa/K ratio was relatively stable after 3 days (adjusted odds ratio of home hypertension per unit increase in the uNa/K ratio for more than 3 days: 1.19-1.23). In conclusion, there was no threshold for the uNa/K ratio, and the morning uNa/K ratio was linearly associated with home hypertension. The Na/K ratio 2.0 calculated from the Dietary Reference Intakes for Japanese might be a good indication. Regarding the stability of the association between the morning uNa/K ratio and BP, more than 3 days of measurements is desirable.

  75. Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of diabetes investigation 13 (5) 858-867 2022年5月

    DOI: 10.1111/jdi.13729  

    詳細を見る 詳細を閉じる

    AIMS/INTRODUCTION: Fat mass and fat-free mass affect glycated hemoglobin A1c (HbA1c) levels and blood glucose levels, respectively. The aim of the present study was to examine the association between fat mass index and fat-free mass index with HbA1c. MATERIALS AND METHODS: We conducted a cross-sectional study that included 3,731 men and 9,191 women aged 20 years or older, living in Miyagi Prefecture, Japan, who were not treated for diabetes. The fat mass index and fat-free mass index were calculated as fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into sex-specific quartiles and combined into 16 groups. An ANCOVA was used to assess associations between the combined fat mass index and fat-free mass index with HbA1c adjusted for potential confounder. The linear trend test was conducted by stratifying the fat mass index and fat free mass index, entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher fat mass index was related to higher HbA1c levels in men and women in all fat-free mass index subgroups (P<0.001 for linear trend). When we excluded the participants who had been pointed out to have diabetes, fat-free mass index was also related to higher HbA1c levels in most fat mass index subgroups (P<0.05 for linear trend). CONCLUSIONS: Fat mass index was positively related to HbA1c levels. Fat free mass index was also related to HbA1c levels when we excluded participants who had been pointed out to have diabetes.

  76. Predictors of early and late mortality after the treatment for early gastric cancers. 国際誌

    Yohei Ogata, Waku Hatta, Yuki Ohara, Tomoyuki Koike, Hiroko Abe, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Akihiro Yamamura, Naoki Tanaka, Takashi Kamei, Michiaki Unno, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 34 (4) 816-825 2022年5月

    DOI: 10.1111/den.14172  

    詳細を見る 詳細を閉じる

    OBJECTIVES: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. METHODS: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of three years. RESULTS: We enrolled 1,439 patients with a median follow-up period of 79 months. The five-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥ 85 years [hazard ratio (HR), 2.88 and 4.54, respectively] and Eastern Cooperative Oncology Group Performance Status ≥ 2 (HR, 3.00 and 4.19, respectively). Charlson comorbidity index ≥ 2 (HR, 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥ 3 (HR, 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥ 0.028 (HR, 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR, 2.26), intermediate- (HR, 2.12)/high-risk (HR, 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR, 1.70) were predictors for early mortality. CONCLUSION: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality.

  77. 統合失調症患者に対するがん検診勧奨法の質的評価 混合研究法を用いた無作為化比較試験の二次解析

    山田 裕士, 藤原 雅樹, 島津 太一, 江藤 剛, 児玉 匡史, 宋 龍平, 松下 貴紀, 吉村 優作, 堀井 茂男, 藤森 麻衣子, 高橋 宏和, 中谷 直樹, 宮路 天平, 樋之津 史郎, 原田 馨太, 岡田 裕之, 内富 庸介, 山田 了士, 稲垣 正俊

    精神神経学雑誌 124 (4付録) S-373 2022年4月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  78. 精神科臨床場面における多職種協働によるがん検診の受診勧奨法のランダム化比較試験

    藤原 雅樹, 山田 裕士, 島津 太一, 児玉 匡史, 宋 龍平, 松下 貴紀, 吉村 優作, 堀井 茂男, 藤森 麻衣子, 高橋 宏和, 中谷 直樹, 掛田 恭子, 宮路 天平, 樋之津 史郎, 原田 馨太, 岡田 裕之, 内富 庸介, 山田 了士, 稲垣 正俊

    精神神経学雑誌 124 (4付録) S-643 2022年4月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  79. Olfactomedin 2 deficiency protects against diet-induced obesity. 国際誌

    Ismael González-García, Óscar Freire-Agulleiro, Naoki Nakaya, Francisco J Ortega, Pablo Garrido-Gil, Laura Liñares-Pose, Johan Fernø, José Luis Labandeira-Garcia, Carlos Diéguez, Afia Sultana, Stanislav I Tomarev, José Manuel Fernández-Real, Miguel López

    Metabolism: clinical and experimental 129 155122-155122 2022年4月

    DOI: 10.1016/j.metabol.2021.155122  

    詳細を見る 詳細を閉じる

    BACKGROUND AND AIMS: Olfactomedin 2 (OLFM2; also known as noelin 2) is a pleiotropic protein that plays a major role in olfaction and Olfm2 null mice exhibit reduced olfactory sensitivity, as well as abnormal motor coordination and anxiety-related behavior. Here, we investigated the possible metabolic role of OLFM2. METHODS: Olfm2 null mice were metabolically phenotyped. Virogenetic modulation of central OLFM2 was also performed. RESULTS: Our data showed that, the global lack of OLFM2 in mice promoted anorexia and increased energy expenditure due to elevated brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT). This phenotype led to resistance to high fat diet (HFD)-induced obesity. Notably, virogenetic overexpression of Olfm2 in the lateral hypothalamic area (LHA) induced weight gain associated with decreased BAT thermogenesis. CONCLUSION: Overall, this evidence first identifies central OLFM2 as a new molecular actor in the regulation of whole-body energy homeostasis.

  80. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. 国際誌

    Nobuo Fuse, Miyuki Sakurai, Ikuko N Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

    Ophthalmology science 2 (1) 100113-100113 2022年3月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.xops.2022.100113  

    ISSN:2666-9145

    詳細を見る 詳細を閉じる

    Purpose: To elucidate the differences in ocular biometric parameters by generation and gender and to identify axial length (AL)-associated genetic variants in Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data. Design: We designed the ToMMo Eye Study, examined AL variations, and conducted genome-wide association studies (GWASs). Participants: In total, 33 483 participants aged > 18 years who were recruited into the community-based cohort (CommCohort) and the birth and three-generation cohort (BirThree Cohort) of the ToMMo Eye Study were examined. Methods: Each participant was screened with an interview, ophthalmic examinations, and a microarray analysis. The GWASs were performed in 22 379 participants in the CommCohort (discovery stage) and 11 104 participants in the BirThree Cohort (replication stage). We evaluated the associations of single nucleotide polymorphisms (SNPs) with AL using a genome-wide significance threshold (5 × 10-8) in each stage of the study and in the subsequent meta-analysis. Main Outcome Measures: We identified the association of SNPs with AL and distributions of AL in right and left eyes and individuals of different sexes and ages. Results: In the discovery stage, the mean AL of the right eye (23.99 mm) was significantly greater than that of the left eye (23.95 mm). This difference was reproducible across sexes and ages. The GWASs revealed 703 and 215 AL-associated SNPs with genome-wide significance in the discovery and validation stages, respectively, and many of the SNPs in the discovery stage were replicated in the validation stage. Validated SNPs and their associated loci were meta-analyzed for statistical significance (P < 5 × 10-8). This study identified 1478 SNPs spread over 31 loci. Of the 31 loci, 5 are known AL loci, 15 are known refractive-error loci, 4 are known corneal-curvature loci, and 7 loci are newly identified loci that are not known to be associated with AL. Of note, some of them shared functional relationships with previously identified loci. Conclusions: Our large-scale GWASs exploiting ToMMo Eye Study data identified 31 loci linked to variations in AL, 7 of which are newly reported in this article. The results revealed genetic heterogeneity and similarity in SNPs related to ethnic variations in AL.

  81. HO-1 in lymph node metastasis predicted overall survival in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiation therapy. 国際誌

    Ryujiro Akaishi, Fumiyoshi Fujishima, Hirotaka Ishida, Junichi Tsunokake, Takuro Yamauchi, Yusuke Gokon, Shunsuke Ueki, Toshiaki Fukutomi, Hiroshi Okamoto, Kai Takaya, Chiaki Sato, Yusuke Taniyama, Tomohiro Nakamura, Naoki Nakaya, Takashi Kamei, Hironobu Sasano

    Cancer reports (Hoboken, N.J.) 5 (3) e1477 2022年3月

    DOI: 10.1002/cnr2.1477  

    詳細を見る 詳細を閉じる

    BACKGROUND: Lymph node metastasis is one of the pivotal factors of the clinical outcomes of patients with esophageal cancer receiving neoadjuvant chemoradiation therapy (NACRT). Both the nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway and heme oxygenase-1 (HO-1) are frequently upregulated in various human malignancies and associated with resistance to chemoradiation therapy, subsequently resulting in adverse clinical outcomes. However, the Nrf2 and HO-1 status in lymph node metastasis and their differences between primary and metastatic lesions are unknown. AIMS: To examine the levels of Nrf2 signaling proteins and HO-1 in primary and metastatic lesions of patients with esophageal squamous cell carcinoma using immunohistochemistry. METHODS AND RESULTS: We immunolocalized Nrf2 signaling proteins in 69 patients with lymph node metastases, who received NACRT with 5-fluorouracil and cisplatin before esophagectomy. We also compared the findings between primary and metastatic lesions. Residual lymph node metastases were detected in 30 patients and among them, both primary and metastatic lesions were available for evaluation in 25 patients. Subsequently, we correlated the results with patients' survival. Nrf2, HO-1, and the Ki-67 labeling index were all significantly lower in the patients with lymph node metastases than in those with primary tumors. Carcinoma cells with high HO-1 levels were significantly associated with pathological resistance to NACRT. These results suggested that overall and disease-free survival of esophageal squamous cell carcinoma were significantly associated with both pN2 and high HO-1 levels, respectively. CONCLUSIONS: Protein expression in the Nrf2 pathway was significantly lower in patients with lymph node metastases than in those with primary lesions. HO-1 levels in lymph node metastases could be used to predict the eventual clinical outcome of patients with esophageal cancer receiving NACRT.

  82. Somatostatin Receptor 2 Expression Profiles and Their Correlation with the Efficacy of Somatostatin Analogues in Gastrointestinal Neuroendocrine Tumors. 国際誌

    Hirofumi Watanabe, Fumiyoshi Fujishima, Izumi Komoto, Masayuki Imamura, Susumu Hijioka, Kazuo Hara, Yasushi Yatabe, Atsushi Kudo, Toshihiko Masui, Takahiro Tsuchikawa, Kazuhiro Sakamoto, Hisashi Shiga, Tomohiro Nakamura, Naoki Nakaya, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

    Cancers 14 (3) 2022年2月2日

    DOI: 10.3390/cancers14030775  

    詳細を見る 詳細を閉じる

    Somatostatin analogues (SSAs) are widely used to treat gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Somatostatin receptor 2 (SSTR2) immunoreactivity serves as a predictive marker of the therapeutic efficacy of SSAs in pancreatic NETs. However, SSTR2 expression profiles in tumor cells and their association with the therapeutic efficacy of SSAs remains virtually unknown in gastrointestinal NETs (GI-NETs). Therefore, we evaluated the association between SSTR2 immunoreactivity and embryological origin and proliferative activity in 132 resected surgical tissues of GI-NETs. The correlation between SSAs' therapeutic efficacy and SSTR2 immunoreactivity was evaluated in 14 GI-NETs treated with SSAs. SSTR2 immunoreactivity was evaluated using Volante scores, immunoreactive scores, and digital image analysis (DIA). SSTR2 immunoreactivity was significantly negatively and positively correlated with the Ki-67 labeling index in foregut and hindgut NETs, respectively. In the normal mucosa, neuroendocrine cells in the rectum had significantly lower positive rates of SSTR2 than those in the stomach and duodenum. SSTR2 expression profiles in GI-NETs could differ by primary sites, while the difference of those between foregut and hindgut NETs might be derived from the SSTR2 status of normal neuroendocrine cell counterparts. In addition, DIA could provide a good alternative for predicting response to SSAs in evaluating SSTR2 immunoreactivity of GI-NETs.

  83. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 32 (Suppl.1) 162-162 2022年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  84. White blood cell count profile in patients with physical complaints without known causes. 国際誌

    Tetsuya Akaishi, Tadashi Ishii, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Masashi Aoki, Atsushi Hozawa

    SAGE open medicine 10 20503121221105328-20503121221105328 2022年

    DOI: 10.1177/20503121221105328  

    詳細を見る 詳細を閉じる

    OBJECTIVES: The aim of this study was to search for routine blood test biomarkers in patients with physical symptoms but without a diagnosis after comprehensive routine screening diagnostic examinations. METHODS: A total of 228 adults aged < 65 years who presented with physical complaints without known causes after comprehensive screening diagnostic examinations and 228 age- and sex-matched healthy controls without physical complaints were enrolled. The blood cell count data at the first hospital visit were compared between these groups. RESULTS: Total white blood cell (p = 0.2143), red blood cell (p = 0.8954), and platelet (p = 0.7716) counts did not differ between the groups. The monocyte count (p = 0.0014) and resultant monocyte-to-lymphocyte ratio (p < 0.0001) were higher in the symptomatic group, while the other white blood cell subtypes did not differ significantly between the two groups. In the symptomatic group, patients with a monocyte-to-lymphocyte ratio > 0.25 were likely to have unexplained nonfocal physical symptoms (p < 0.0001). The characteristic findings included fatigability (p < 0.0001), prolonged slight fever (p = 0.0005), and widespread pain (p < 0.0001). The monocyte-to-lymphocyte ratio level was correlated with the proportion of patients with unexplained nonfocal symptoms. CONCLUSION: The blood cell count profile was largely the same between healthy individuals and patients with unexplained physical symptoms. However, patients with unexplained nonfocal physical complaints were likely to show an elevated monocyte-to-lymphocyte ratio, typically > 0.25.

  85. 地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと 健診機関とのタイアップ

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 菅野 郁美, 板橋 芙美, 黒川 悦子, 大川 亜美, 宮川 健, 永吉 翔, 牛田 悠介, 清水 友紀子, 上田 宏幸, 土屋 菜歩, 中谷 直樹, 寳澤 篤

    総合健診 49 (1) 205-205 2022年1月

    出版者・発行元:(一社)日本総合健診医学会

    ISSN:1347-0086

    eISSN:1884-4103

  86. 脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

    高瀬 雅仁, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 土屋 菜歩, 平田 匠, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 32 (Suppl.1) 126-126 2022年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  87. 脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

    高瀬 雅仁, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 土屋 菜歩, 平田 匠, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 32 (Suppl.1) 126-126 2022年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  88. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. 国際誌

    Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Jun Yasuda, Yumi Yamaguchi-Kabata, Kengo Kinoshita, Soichi Ogishima, Takako Takai, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naoko Minegishi, Junichi Sugawara, Kichiya Suzuki, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Yayoi Aizawa, Tomoharu Tokutomi, Kayono Yamamoto, Kinuko Ohneda, Shigeo Kure, Yoko Aoki, Hideki Katagiri, Yasushi Ishigaki, Shojiro Sawada, Makoto Sasaki, Masayuki Yamamoto

    Journal of human genetics 67 (1) 9-17 2022年1月

    DOI: 10.1038/s10038-021-00952-8  

    詳細を見る 詳細を閉じる

    Certain large genome cohort studies attempt to return the individual genomic results to the participants; however, the implementation process and psychosocial impacts remain largely unknown. The Tohoku Medical Megabank Project has conducted large genome cohort studies of general residents. To implement the disclosure of individual genomic results, we extracted the potential challenges and obstacles. Major challenges include the determination of genes/disorders based on the current medical system in Japan, the storage of results, prevention of misunderstanding, and collaboration of medical professionals. To overcome these challenges, we plan to conduct multilayer pilot studies, which deal with different disorders/genes. We finally chose familial hypercholesterolemia (FH) as a target disease for the first pilot study. Of the 665 eligible candidates, 33.5% were interested in the pilot study and provided consent after an educational "genetics workshop" on the basic genetics and medical facts of FH. The genetics professionals disclosed the results to the participants. All positive participants were referred to medical care, and a serial questionnaire revealed no significant psychosocial distress after the disclosure. Return of genomic results to research participants was implemented using a well-prepared protocol. To further elucidate the impact of different disorders, we will perform multilayer pilot studies with different disorders, including actionable pharmacogenomics and hereditary tumor syndromes.

  89. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. 国際誌

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human genome variation 8 (1) 44-44 2021年12月10日

    DOI: 10.1038/s41439-021-00175-5  

    詳細を見る 詳細を閉じる

    To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  90. The prevalence of current smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer among participants in a community-based cardiometabolic screening program in Miyagi prefecture, Japan: a comparison with nationally representative surveys in other countries. 国際誌

    Yuka Nishimoto, Yoshitaka Tsubono, Mana Kogure, Tomohiro Nakamura, Fumi Itabashi, Naho Tsuchiya, Naoki Nakaya, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Shigeo Kure, Ichiro Tsuji, Atsushi Hozawa

    Cancer medicine 10 (24) 9000-9011 2021年12月1日

    DOI: 10.1002/cam4.4364  

    詳細を見る 詳細を閉じる

    BACKGROUND: We determined the prevalence of current cigarette smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer in Japan and compared the findings with nationally representative studies in other countries. METHODS: We conducted a cross-sectional study of baseline data from a prospective cohort study. A self-administered questionnaire was surveyed during 2013-2015 with residents aged ≥20 years attending a community-based cardiometabolic screening program in Miyagi prefecture in north-eastern Japan. Subjects with past cancer histories were classified as cancer survivors. Sex-specific, age-standardized prevalence of current smokers, and drinkers were calculated. Age-adjusted prevalence ratios (PRs: the cancer survivors' rate divided by the rate of subjects with no history of cancer) and 95% confidence intervals (CIs) were estimated with log-binomial regressions. RESULTS: 36,786 subjects, including 2760 cancer survivors, responded and provided usable information (58.9% of recruited subjects). For men, the age-standardized prevalence of current smokers and drinkers among survivors was 18.8% and 74.4%, respectively, with an age-adjusted PR (95%CI) of 0.76 (0.66-0.86, p < 0.001) and 0.95 (0.91-0.98, p = 0.002), respectively. For women, the figures were 6.1%, 37.9%, 0.84 (0.67-1.06, p = 0.138) and 0.96 (0.90-1.03, p = 0.313), respectively. The U.S., the U.K, and Australian studies generally showed no substantially lower prevalence of current smokers or drinkers in survivors than in subjects with no history of cancer (PR ≥ 0.75), while Korean studies did (PR < 0.75). CONCLUSIONS: A considerable proportion of Japanese cancer survivors, especially men, remained currently smoking and drinking. Consistent with Western studies, the rates were not substantially lower than those among subjects with no history of cancer.

  91. The association between psychological distress and risk of incident functional disability in elderly survivors after the Great East Japan Earthquake: The mediating effect of lifestyle and bodily pain. 国際誌

    Toshimasa Sone, Yumi Sugawara, Fumiya Tanji, Naoki Nakaya, Hiroaki Tomita, Ichiro Tsuji

    Journal of affective disorders 295 552-558 2021年12月1日

    DOI: 10.1016/j.jad.2021.08.068  

    詳細を見る 詳細を閉じる

    BACKGROUND: We previously reported that psychological distress was associated with an increased risk of functional disability. However, the mechanism of the association remains unclear. Our aim was to estimate the mediating effect of lifestyle and bodily pain on the association among elderly survivors after the Great East Japan Earthquake. METHODS: The study population comprised 1037 residents aged ≥ 65 years. The baseline surveys (exposure and mediators) were conducted in 2011. We classified participants into three categories according to their Kessler 6 score (low: 0-9, moderate: 10-12, and high: 13-24) and defined functional disability as certification for long-term care insurance in Japan. The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident functional disability according to Kessler 6 categories and explored the mediating effects of lifestyle and bodily pain on the association. RESULTS: During approximately 8 years of follow-up, we documented 271 incident cases of functional disability. Compared with those in the low distress group, the multivariate adjusted HR for incident functional disability was 1.95 (95% CI 1.21-3.13) for those in the high distress group. Time spent walking, going out, and bodily pain significantly mediated the association between psychological distress and incident functional disability by 10.2%, 10.5%, and 10.3% for the high distress group, respectively. LIMITATIONS: We did not consider unmeasured confounders and use of appropriate medication. CONCLUSIONS: The evaluation and treatment of bodily pain as well as promotion of active lifestyle would be important for preventing disability among disaster survivors.

  92. Cancer care for people with mental disorders: A qualitative survey among cancer care and psychiatric care professionals in Japan. 国際誌

    Tsuyoshi Etoh, Masaki Fujiwara, Yuto Yamada, Riho Wada, Yuji Higuchi, Shinichiro Inoue, Masafumi Kodama, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Kyoko Kakeda, Taichi Shimazu, Naoki Nakaya, Masahiro Tabata, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Psycho-oncology 30 (12) 2060-2066 2021年12月

    DOI: 10.1002/pon.5780  

    詳細を見る 詳細を閉じる

    OBJECTIVE: It is widely assumed that there are multiple levels (from individual to policy level) of problems involving disparities in cancer care for people with mental disorders. However, few studies have comprehensively investigated issues as perceived by medical professionals. The purpose of the present study was to identify a wide range of issues in cancer care for people with mental disorders and offer corresponding solutions for both cancer care professionals and psychiatric care professionals. METHODS: We distributed open-ended questionnaires to 754 healthcare professionals in various medical facilities, including designated cancer hospitals, psychiatric hospitals, and other local healthcare/welfare facilities. Participants were asked to describe issues in cancer care for people with mental disorders. RESULTS: Of the 754 recruited professionals, 439 (58.2%) responded to the questionnaire. Sixty-one issues were extracted and categorized into 10 categories: patient factors; isolation and lack of support; obstacles to transport; socioeconomic factors; attitudes of psychiatric professionals; medical system of psychiatric hospitals; attitudes of cancer care professionals; medical system of designated cancer hospitals; regional cancer medical systems; and lack of coordination among multidisciplinary healthcare professionals. Forty-eight specific solutions were summarized into 12 goals. CONCLUSIONS: The present study widely identified issues causing disparities in cancer care for patients with mental disorders. We found that the issues extended from the patient level to the public-policy level. Our findings suggest the need for a multidisciplinary approach that includes both cancer and psychiatric care professionals to address the gap in cancer care for people with mental disorders.

  93. White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. 国際誌

    Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

    Scientific reports 11 (1) 22357-22357 2021年11月16日

    DOI: 10.1038/s41598-021-01942-8  

    詳細を見る 詳細を閉じる

    Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system; however, its exact mechanism is unknown. This study aimed to elucidate the profile of white blood cells (WBCs) in the acute phase of an MS attack. Sixty-four patients with MS at the time of diagnosis and 2492 age- and sex-adjusted healthy controls (HCs) were enrolled. Data regarding the blood cell counts were compared between the groups. The total WBC (p < 0.0001), monocyte (p < 0.0001), basophil (p = 0.0027), and neutrophil (p < 0.0001) counts were higher in the MS group than in the HC group, whereas the lymphocyte and eosinophil counts did not differ. Adjustments for the smoking status and body mass index yielded the same results. The total and differential WBC counts of the patients with MS did not correlate with the counts of T2 hyperintense brain lesions or the levels of neurological disturbance. In summary, patients with MS showed elevated counts of total WBCs, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.

  94. Impact of type of reconstructed residence on social participation and mental health of population displaced by disasters. 国際誌

    Tomomi Suzuki, Tetsuya Akaishi, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Scientific reports 11 (1) 21465-21465 2021年11月2日

    DOI: 10.1038/s41598-021-00913-3  

    詳細を見る 詳細を閉じる

    After disasters, people are often forced to reconstruct or move to new residences. This study aimed to reveal the association between the types of reconstructed residences and psychosocial or psychiatric conditions among the population. A total of 1071 adult residents in a coastal town, whose houses were destroyed by the tsunami caused by the Great East Japan Earthquake, enrolled in the study five years after the disaster. The type of reconstructed post-disaster residences (reconstructed on the same site/disaster-recovery public condominium/mass-translocation to higher ground/privately moving to remote areas) and the current psychosocial indicators were investigated. The results revealed that individuals living in public condominiums showed significantly worse scores on the Lubben Social Network Scale-6 (p < 0.0001) and the Center for Epidemiologic Studies Depression Scale (p < 0.0001), and slightly worse scores on the Kessler Psychological Distress Scale (p = 0.035) and the Impact of Event Scale-Revised (p = 0.028). Lower psychosocial indicator scores in the public condominium group were more remarkable in younger adults aged < 65 years. Insomnia evaluated using the Athens Insomnia Scale was not different among the four residential types. In summary, residents moving into disaster-recovery public condominiums are likely to have less social interaction, be more depressed, and may need additional interventions.

  95. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 80回 219-219 2021年11月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  96. 統合失調症患者における日本語版WHODAS 2.0 12項目自己記入版の妥当性、信頼性の検討

    和田 里穂, 藤原 雅樹, 山田 裕士, 中谷 直樹, 藤森 麻衣子, 宋 龍平, 児玉 匡史, 樋口 裕二, 掛田 恭子, 内富 庸介, 山田 了士, 稲垣 正俊

    総合病院精神医学 33 (Suppl.) S-165 2021年11月

    出版者・発行元:(一社)日本総合病院精神医学会

    ISSN:0915-5872

  97. Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study. 国際誌

    Masato Takase, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Akira Narita, Takumi Hirata, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Clinical and experimental hypertension (New York, N.Y. : 1993) 43 (7) 610-621 2021年10月3日

    DOI: 10.1080/10641963.2021.1925681  

    詳細を見る 詳細を閉じる

    BACKGROUND: A  higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. METHODS: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. RESULTS: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. CONCLUSIONS: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.

  98. Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies. 国際誌

    Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, Akira Narita, Tomohiro Nakamura, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Harold Snieder, Shinichi Kuriyama

    Atherosclerosis 334 85-92 2021年10月

    DOI: 10.1016/j.atherosclerosis.2021.08.037  

    詳細を見る 詳細を閉じる

    BACKGROUND AND AIMS: Few studies have examined and compared spousal concordance in different populations. This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations. METHODS: This cross-sectional study included 28,265 Dutch Lifelines Cohort Study spouse pairs (2006-2013) and 5,391 Japanese Tohoku Medical Megabank Organization (ToMMo) Cohort Study pairs (2013-2016). Spousal similarities in cardiometabolic risk factors were evaluated using Pearson's correlation or logistic regression analyses adjusted for spousal age. RESULTS: The husbands' and wives' average ages in the Lifelines and ToMMo cohorts were 50.0 and 47.7 years and 63.2 and 60.4 years, respectively. Significant spousal similarities occurred with all cardiometabolic risk factors and diseases of interest in both cohorts. The age-adjusted correlation coefficients ranged from 0.032 to 0.263, with the strongest correlations observed in anthropometric traits. Spousal odds ratios [95% confidence interval] for the Lifelines vs. ToMMo cohort ranged from 1.45 (1.36-1.55) vs. 1.20 (1.05-1.38) for hypertension to 6.86 (6.30-7.48) vs. 4.60 (3.52-6.02) for current smoking. An increasing trend in spousal concordance with age was observed for sufficient physical activity in both cohorts. For current smoking, those aged 20-39 years showed the strongest concordance between pairs in both cohorts. The Dutch pairs showed stronger similarities in anthropometric traits and lifestyle habits (smoking and drinking) than their Japanese counterparts. CONCLUSIONS: Spouses showed similarities in several cardiometabolic risk factors among Dutch and Japanese populations, with regional and cultural influences on spousal similarities.

  99. Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial. 国際誌

    Masaki Fujiwara, Yuto Yamada, Taichi Shimazu, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Kyoko Kakeda, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Acta psychiatrica Scandinavica 144 (4) 318-328 2021年10月

    DOI: 10.1111/acps.13348  

    詳細を見る 詳細を閉じる

    OBJECTIVE: We examined the efficacy of a case management approach to improve participation in colorectal cancer screening among people with schizophrenia. METHODS: This was a randomized, parallel group trial. We recruited outpatients with schizophrenia aged 40 years or over from two psychiatric hospitals in Japan. Participants were randomly assigned (1:1) to treatment as usual or case management intervention plus treatment as usual using a web-based system. Attending clinicians and participants were unmasked to the allocation. Case management included education and patient navigation for colorectal cancer screening using a fecal occult blood test. Treatment as usual included direct mail government recommendations. The primary endpoint was participation in colorectal cancer screening assessed using municipal records. We also assessed the secondary endpoint of participation in other cancer screenings (lung, gastric, breast, and cervical). RESULTS: Between June 3 and September 9, 2019, 172 eligible participants were randomly assigned to the case management plus treatment as usual group (n=86) or treatment as usual group (n=86). One participant was ineligible and another withdrew consent; both were excluded from analysis. A significantly higher proportion of participants received colorectal cancer screening in the case management plus treatment as usual group than in the treatment as usual group (40 [47.1%] of 85 participants vs. 10 [11.8%] of 85 participants, P<0.0001). The proportion of lung cancer screening also increased. No serious adverse events associated with the study intervention occurred. CONCLUSION: The case management intervention to encourage participation in colorectal cancer screening was effective for patients with schizophrenia.

  100. Necroptosis in Esophageal Squamous Cell Carcinoma: An Independent Prognostic Factor and Its Correlation with Tumor-Infiltrating Lymphocytes. 国際誌

    Takuro Yamauchi, Fumiyoshi Fujishima, Masatoshi Hashimoto, Junichi Tsunokake, Ryujiro Akaishi, Yusuke Gokon, Shunsuke Ueki, Yohei Ozawa, Toshiaki Fukutomi, Hiroshi Okamoto, Chiaki Sato, Yusuke Taniyama, Tomohiro Nakamura, Naoki Nakaya, Takashi Kamei, Hironobu Sasano

    Cancers 13 (17) 2021年9月5日

    DOI: 10.3390/cancers13174473  

    詳細を見る 詳細を閉じる

    Necroptosis is a pivotal process in cancer biology; however, the clinical significance of necroptosis in esophageal squamous cell carcinoma (ESCC) has remained unknown. Therefore, in this study, we aimed to verify the potential involvement of necroptosis in the clinical outcome, chemotherapeutic resistance, and tumor microenvironment of ESCC. Mixed lineage kinase domain-like protein (MLKL) and phosphorylated MLKL (pMLKL) were immunohistochemically examined in 88 surgically resected specimens following neoadjuvant chemotherapy (NAC) and 53 pre-therapeutic biopsy specimens, respectively. Tumor-infiltrating lymphocytes (TILs) were also evaluated by immunolocalizing CD3, CD8, and forkhead box protein 3 (FOXP3) in the residual tumors after NAC. High pMLKL status in the post-NAC resected specimens was significantly correlated with worse prognosis in ESCC patients. Multivariate analysis demonstrated that a high pMLKL status was an independent prognostic factor. In pre-NAC biopsy specimens, a high pMLKL status was significantly associated with a lower therapeutic efficacy. CD8+ TILs were significantly lower in the high-pMLKL group. FOXP3+ TILs were significantly higher in both high-MLKL and high-pMLKL groups. We first demonstrated pMLKL status as an independent prognostic factor in ESCC patients. Our study revealed the possible involvement of necroptosis in the immunosuppressive microenvironment, resulting in the attenuated therapeutic efficacy of NAC and eventual adverse clinical outcomes in ESCC.

  101. Prevention of delayed bleeding with vonoprazan in upper gastrointestinal endoscopic treatment.

    Hiroko Abe, Waku Hatta, Yohei Ogata, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Kunio Tarasawa, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

    Journal of gastroenterology 56 (7) 640-650 2021年7月

    DOI: 10.1007/s00535-021-01781-4  

    詳細を見る 詳細を閉じる

    BACKGROUND: Delayed bleeding is the major adverse event in upper gastrointestinal endoscopic treatment (UGET). We aimed to investigate the efficacy of vonoprazan, which is the novel strong antisecretory agent, to reduce the risk for delayed bleeding in comparison with proton pump inhibitors (PPIs) in UGET. METHODS: This retrospective population-based cohort study used the Diagnosis Procedure Combination database in Japan. We included patients on vonoprazan or PPI in UGET between 2014 and 2019. The primary outcome was delayed bleeding. We conducted propensity score matching to balance the comparison groups, and logistic regression analyses to compare the bleeding outcomes. RESULTS: We enrolled 124,422 patients, in which 34,822 and 89,600 were prescribed with vonoprazan and PPI, respectively. After propensity score matching, the risk for delayed bleeding was lower in vonoprazan than in PPI (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.71-0.80), consistent with sensitivity analysis results. In the subgroup analyses of seven UGET procedures, vonoprazan was significantly advantageous in esophageal endoscopic submucosal dissection (E-ESD) (OR, 0.71; 95% CI, 0.54-0.94) and gastroduodenal endoscopic submucosal dissection (GD-ESD) (OR, 0.70; 95% CI, 0.65-0.75), although correction for multiple testing of the outcome data removed the significance in E-ESD. These results were also consistent with sensitivity analysis results. In the five other procedures, no significant advantage was found. CONCLUSIONS: This nationwide study found that, compared with PPI, vonoprazan can reduce delayed bleeding with approximately 30% in GD-ESD. Vonoprazan has the possibility to become a new treatment method for preventing delayed bleeding in this procedure.

  102. Risk of metastatic recurrence after endoscopic resection for esophageal squamous cell carcinoma invading into the muscularis mucosa or submucosa: a multicenter retrospective study.

    Waku Hatta, Tomoyuki Koike, So Takahashi, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Ippei Tanaka, Yusuke Onozato, Koichi Hamada, Daisuke Fukushi, Ko Watanabe, Shoichi Kayaba, Hirotaka Ito, Tatsuya Mikami, Tomoyuki Oikawa, Yasushi Takahashi, Yutaka Kondo, Tetsuro Yoshimura, Takeharu Shiroki, Ko Nagino, Norihiro Hanabata, Akira Funakubo, Dai Hirasawa, Tetsuya Ohira, Jun Nakamura, Takayuki Matsumoto, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Shinsaku Fukuda, Atsushi Masamune

    Journal of gastroenterology 56 (7) 620-632 2021年7月

    DOI: 10.1007/s00535-021-01787-y  

    詳細を見る 詳細を閉じる

    BACKGROUND: We aimed to elucidate the risk of metastatic recurrence after endoscopic resection (ER) without additional treatment for esophageal squamous cell carcinomas (ESCCs) with tumor invasion into the muscularis mucosa (pT1a-MM) or submucosa (T1b-SM). METHODS: We retrospectively enrolled patients with pT1a-MM/pT1b-SM ESCC after ER at 21 institutions in Japan between 2006 and 2017. We compared metastatic recurrence between patients with and without additional treatment, stratified into category A (pT1a-MM with negative lymphovascular invasion [LVI] and vertical margin [VM]), B (tumor invasion into the submucosa ≤ 200 µm [pT1b-SM1] with negative LVI and VM), and C (others). Subsequently, using multivariate Cox analysis, we evaluated risk factors for metastatic recurrence after ER without additional treatment. RESULTS: We enrolled 593 patients, and metastatic recurrence occurred in 38 patients. Metastatic recurrence after additional treatment was significantly lower than that after no additional treatment in category C (9.1% vs. 23.6% in 5 years, p = 0.001), whereas no significant difference was noted in categories A (0.0% vs. 2.6%) and B (0.0% vs. 4.3%). In patients without additional treatment after ER, risk factors for metastatic recurrence were lymphatic invasion (hazard ratio [HR], 5.61), positive VM (HR, 4.55), and tumor invasion into the submucosa > 200 μm (HR, 3.25), and, but near half of the patients with metastatic recurrence had no further recurrence after salvage treatment, resulting in excellent 5-year disease-specific survival in categories A (99.6%) and B (100.0%). CONCLUSIONS: Closed follow-up with no additional treatment may be an acceptable option after ER in pT1a-MM/pT1b-SM1 ESCC with negative LVI and VM.

  103. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. 国際誌

    Takumi Hirata, Mana Kogure, Naho Tsuchiya, Ken Miyagawa, Akira Narita, Kotaro Nochioka, Akira Uruno, Taku Obara, Tomohiro Nakamura, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 44 (7) 858-865 2021年7月

    DOI: 10.1038/s41440-021-00628-y  

    詳細を見る 詳細を閉じる

    Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese population. We conducted a cross-sectional study including 1384 participants (393 men and 991 women) to estimate the odds ratio (OR) and 95% confidence interval (CI) for the presence of any of the conventional risk factors using multivariable logistic regression analyses. The models were adjusted for sex, age, smoking status, and log-transformed average daily steps. We also estimated the OR and 95% CI for the presence of any of the overall risk factors. Furthermore, we calculated the PAF due to these risk factors. The results showed that the prevalence of home hypertension was 39.0% (540/1384). The presence of any of the conventional risk factors, as well as any of the overall risk factors, was significantly associated with an increased prevalence of hypertension (OR 2.80, 95% CI 2.15-3.65; OR 2.50, 95% CI 1.93-3.22, respectively). The PAF for hypertension due to the presence of any of the conventional risk factors and the PAF due to the presence of any of the overall risk factors were 30.2% and 39.0%, respectively. In conclusion, the impact of the overall risk factors, including the urinary Na/K ratio and sleep efficiency, on home hypertension was higher than that of conventional risk factors alone. The management of the urinary Na/K ratio and sleep efficiency as well as conventional risk factors might be important in the management of blood pressure.

  104. Five-year Psychosocial Impact of Living in Post-Disaster Prefabricated Temporary Housing. 国際誌

    Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Disaster medicine and public health preparedness 1-31 2021年6月23日

    DOI: 10.1017/dmp.2021.212  

    詳細を見る 詳細を閉じる

    OBJECTIVE: This study aims to evaluate the long-term impact of living in post-disaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held five years after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on five types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants five years after the disaster. CONCLUSIONS: Living in post-disaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities five years later.

  105. miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage. 国際誌

    Ben Mead, Alicia Kerr, Naoki Nakaya, Stanislav I Tomarev

    Cells 10 (7) 2021年6月22日

    DOI: 10.3390/cells10071564  

    詳細を見る 詳細を閉じる

    The purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension/glaucoma. Rats were separated into four groups: healthy/intact, 7 days after laser-induced ocular hypertension, 2 days after traumatic ONC, and 7 days after ONC. RGC were purified from rat retina using microbeads conjugated to CD90.1/Thy1. RNA were sequenced using Next Generation Sequencing. Over 100 miRNA were identified that were significantly different in diseased retina compared to healthy retina. Considerable differences were seen in the miRNA expression of RGC 7 days after ONC, whereas after 2 days, few changes were seen. The miRNA profiles of RGC 7 days after ONC and 7 days after ocular hypertension were similar, but discrete miRNA differences were still seen. Candidate mRNA showing different levels of expression after retinal injury were manipulated in RGC cultures using mimics/AntagomiRs. Of the five candidate miRNA identified and subsequently tested for therapeutic efficacy, miR-194 inhibitor and miR-664-2 inhibitor elicited significant RGC neuroprotection, whereas miR-181a mimic and miR-181d-5p mimic elicited significant RGC neuritogenesis.

  106. Does a combination treatment of repetitive transcranial magnetic stimulation and occupational therapy improve upper limb muscle paralysis equally in patients with chronic stroke caused by cerebral hemorrhage and infarction?: A retrospective cohort study. 国際誌

    Hisashi Tatsuno, Toyohiro Hamaguchi, Jinichi Sasanuma, Kiyohito Kakita, Takatsugu Okamoto, Masato Shimizu, Naoki Nakaya, Masahiro Abo

    Medicine 100 (24) e26339 2021年6月18日

    DOI: 10.1097/MD.0000000000026339  

    詳細を見る 詳細を閉じる

    ABSTRACT: The clinical presentation of stroke is usually more severe in patients with intracerebral hemorrhage (ICH) than in those with cerebral infarction (CI); recovery of stroke-related muscle paralysis is influenced and limited by the type of stroke. To date, many patients have been treated by neurorehabilitation; however, the changes in the recovery of motor paralysis depending on the type of stroke, ICH or CI, have not been established. This study aimed to determine this difference in improvement of upper extremity paralysis using 2-week in-hospital NovEl intervention Using Repetitive transcranial magnetic stimulation combined with Occupational therapy (NEURO).We scrutinized the medical records of all patients with poststroke (ICH or CI) upper extremity muscle paralysis using Fugl-Meyer assessments (FMAs) who had been admitted to 6 hospitals between March 2010 and December 2018 for rehabilitation treatment. This was a multiinstitutional, open-label, retrospective cohort study without control patients. We evaluated the effects of NEURO on patients with CI and ICH by dividing them into 2 groups according to the type of stroke, after adjustment for age, sex, dominant hand, affected hand side, time since stroke, and prediction of recovery capacity in the upper extremity.The study included 1716 (CI [n = 876] and ICH [n = 840]) patients who had undergone at least 2 FMAs and had experienced stroke at least 6 months before. The type of stroke had no effect on the outcomes (changes in the FMA-upper extremity score, F[4,14.0] = 2.05, P = .09, partial η2 = 0.01). Patients from all 5 groups equally benefited from the treatment (improvement in FMA scores) according to the sensitivity analysis-stratified analysis (F = 0.08 to 1.94, P > .16, partial η2 < 0.001).We conclude that NEURO can be recommended for chronic stroke patients irrespective of the type of stroke.

  107. Correction to: a Cross-sectional Study of Attention Bias for Facial Expression Stimulation in Patients with Stroke at the Convalescence Stage. 国際誌

    Hirokazu Takizawa, Toshiyuki Ishioka, Kohei Koizumi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Toyohiro Hamaguchi

    International journal of behavioral medicine 28 (3) 401-401 2021年6月

    DOI: 10.1007/s12529-020-09948-8  

  108. Validity and Reliability of the Japanese Version of the 12-item Self-administered World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in Patients with Schizophrenia.

    Riho Wada, Masaki Fujiwara, Yuto Yamada, Naoki Nakaya, Maiko Fujimori, Ryuhei So, Masafumi Kodama, Yuji Higuchi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Acta medica Okayama 75 (3) 315-322 2021年6月

    DOI: 10.18926/AMO/62226  

    詳細を見る 詳細を閉じる

    It is necessary to assess functional impairment when treating schizophrenia. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) has been adopted as a measure of functional disability in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. This study was a secondary analysis from a cross-sectional study of health-related behaviors among patients with schizophrenia. We examined the validity and reliability of the Japanese version of the 12-item WHODAS 2.0 when self-administered by such patients. Participants were 350 outpatients with schizophrenia from a psychiatric hospital. The standard six-factor structure of the WHODAS 2.0 showed a good fit for these participants. The Cronbach's alpha coefficient was 0.858, showing good internal consistency. The WHODAS 2.0 showed moderate correlations with the modified Global Assessment of Functioning and Kessler 6 scales (r=-0.434 and 0.555, respectively). The results of this study show that the Japanese version of the 12-item self-administered WHODAS 2.0 has good internal consistency and convergent validity among patients with schizophrenia. Further exploration of the usefulness of WHODAS 2.0 in clinical settings is needed.

  109. Association between the social isolation and depressive symptoms after the great East Japan earthquake: findings from the baseline survey of the TMM CommCohort study. 国際誌

    Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Eri Takusari, Kotaro Otsuka, Hiroaki Tomita, Ryohei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yasuyuki Taki, Atsushi Shimizu, Jiro Hitomi, Mamoru Satoh, Makoto Sasaki

    BMC public health 21 (1) 925-925 2021年5月15日

    DOI: 10.1186/s12889-021-10896-5  

    詳細を見る 詳細を閉じる

    BACKGROUND: Social isolation and mental health issues have become a severe problem in disaster areas in the Great East Japan Earthquake. This study examined whether the combination of the house damage and social isolation or the combination of the death of family members and social isolation is associated with depressive symptoms among survivors using the baseline study data of the Tohoku Medical Megabank Project Community-Based Cohort Study (TMM CommCohort Study). METHODS: We used cross-sectional data from a baseline survey of 48,958 participants (18,423 males, 30,535 females; aged 60.1 ± 11.2 years) to examine the association between social isolation measured by the Lubben social network scale 6 (LSNS-6) and depressive symptoms measured by the Center for Epidemiological Studies-Depressive Scale (CES-D). The presence of social isolation and depressive symptoms was defined by an LSNS-6 score of < 12 and a CES-D score of ≥16, respectively. We performed a logistic regression analysis to determine the multivariable-adjusted odds ratio (95% confidence interval) [AOR (95% CI)] for depressive symptoms according to sex in the social isolation in comparison to without social isolation, and the associations of the combination of the house damage or the death of family members and social isolation and depressive symptoms. RESULTS: Social isolation was significantly associated with depressive symptoms (males: OR = 1.87; 95% CI = 1.72-2.04, females: OR = 2.13; 95% CI = 2.00-2.26). Both males and females respondents with severe house damage and social isolation had a greater risk of depressive symptoms in comparison to those with an undamaged house and without social isolation (males: OR = 3.40; 95% CI = 2.73-4.24, females: OR = 2.92; 95% CI = 2.46-3.46). The risk of depressive symptoms was also higher in both males and females respondents with the death of family members and social isolation in comparison to those without the death of family members and without social isolation (males: OR = 2.18; 95% CI = 1.90-2.50, females: OR = 2.60; 95% CI = 2.35-2.88). CONCLUSION: The findings suggested that a combination of social isolation and severe house damage and the death of family members caused by a large-scale natural disaster was associated with a higher risk of depressive symptoms although the interaction was not statistically significant.

  110. [Role of Palliative Care in the Introduction of Chemotherapy in Patients with Poor Performance Status].

    Itaru Sato, Naoki Nakaya, Yoko Obara, Natsumi Kurosaka, Souichirou Ueno, Hideo Nakajima

    Gan to kagaku ryoho. Cancer & chemotherapy 48 (5) 735-737 2021年5月

    ISSN:0385-0684

    詳細を見る 詳細を閉じる

    Chemotherapy for patients with poor performance status(PS)is not recommended because it increases the risk of death and shortens their survival. We report on 3 cases in which palliative care improved PS and enabled chemotherapy, resulting in a prolonged prognosis. Case 1 involves a 57‒year‒old woman with multiple lung, liver, and bone metastases from breast cancer who was administered celecoxib and oxycodone. She received Mohs paste therapy. Her PS improved from 3 to 2, and paclitaxel and trastuzumab were started; however, the patient died on day 861. Case 2 involves a 53‒year‒old woman with multiple lymph node metastases from carcinoma of an unknown primary cause. She was administered oxycodone, loxoprofen, and dexamethasone. Her PS improved from 4 to 3. The biopsy of her bone marrow showed diffuse large B‒cell lymphoma. The patient is still alive, 6 years and 10 months after the introduction of R‒CHOP. In case 3, a 57‒year‒old man with multiple bone metastases from small cell lung cancer was administered loxoprofen and betamethasone. His PS improved from 4 to 3. Etoposide and carboplatin were administered to him, but the patient died on day 692. Palliative care may enable the introduction of chemotherapy and consequently improve prognosis.

  111. Efficacy of attention bias modification combined with cognitive behavioral therapy for reducing anxiety in patients with hematopoietic malignancies: a quasi-randomized controlled trial

    Koizumi Kohei, Hamaguchi Toyohiro, Tayama Jun, Ishioka Toshiyuki, Nakamura-Thomas Hiromi, Koike Yuji, Nakaya Naoki, Konno Michiko, Makita Shigeru

    Journal of Affective Disorders Reports 4 100122-100122 2021年4月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.jadr.2021.100122  

    ISSN:2666-9153

  112. 機能性消化管疾患群における便通異常ならびに消化管通過に対するkiwifruitとpsylliumの比較検証試験

    大川 洋平, 中谷 久美, 村椿 智彦, 岡本 智子, 布田 美貴子, 遠藤 由香, 鹿野 理子, 金澤 素, 中谷 直樹, Barbara Giovanni, Gearry Richard, Ansell Juliet, Kuhn-Sherlock Barbara, Drummond Lynley, 福土 審

    心身医学 61 (2) 197-198 2021年3月

    出版者・発行元:(一社)日本心身医学会

    ISSN:0385-0307

  113. Coffee consumption and mortality in Japan with 18 years of follow-up: the Jichi Medical School Cohort Study 査読有り

    T. Sakamaki, K. Kayaba, K. Kotani, M. Namekawa, T. Hamaguchi, N. Nakaya, S. Ishikawa

    Public Health 191 23-30 2021年2月

    出版者・発行元:None

    DOI: 10.1016/j.puhe.2020.10.021  

    ISSN:0033-3506

    詳細を見る 詳細を閉じる

    Objective: Coffee consumption can be expected to reduce mortality due to cardiovascular diseases and cancer. This study tested the hypothesis of an inverse association between coffee intake and all-cause mortality and mortality due to cancer, coronary heart disease, or stroke. Study design: Prospective cohort study. Methods: We analyzed data from the Jichi Medical School Cohort Study, Japan, enrolling 9946 subjects (men/women: 3870/6,076, age: 19e93 years) from 12 communities. A food frequency questionnaire assessing the subjects’ daily coffee consumption was used. Results: During an average follow-up of 18.4 years, the total number of deaths was 2024, including 677 for cancer, 238 for coronary heart disease, and 244 for stroke. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause mortality and cause specific mortality due to cancer, coronary heart disease, and stroke. Overall, no significant association was shown between coffee consumption and all-cause mortality. In the cause-specific mortality analyses, stroke mortality was significantly lower in those who consumed 1e2 cups of coffee daily (HR [95% CI]: 0.63 [0.42e0.95]) than in those who do not consume coffee, and this association occurred only in men. Conclusion: This study showed no significant association between coffee consumption and all-cause mortality. A U-shaped association between coffee consumption and stroke mortality with a 37% lower stroke mortality, only significant in men who consume 1e2 cups of coffee daily was observed. It is necessary to examine the possibility of intervention studies to reduce stroke mortality through coffee consumption.

  114. 回復期脳卒中患者の表情刺激に対する注意バイアスには心理状態と認知機能が影響する

    滝澤 宏和, 小泉 浩平, 田山 淳, 中谷 直樹, 濱口 豊太

    行動医学研究 26 (Suppl.) 48-48 2021年

    出版者・発行元:日本行動医学会

    ISSN:1341-6790

    eISSN:2188-0085

  115. 東日本大震災被災高齢者における心理的苦痛と要介護発生リスクとの関連 生活習慣と疼痛の媒介効果

    曽根 稔雅, 菅原 由美, 丹治 史也, 中谷 直樹, 辻 一郎

    Journal of Epidemiology 31 (Suppl.) 93-93 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  116. 脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

    高瀬 雅仁, 中村 智洋, 平田 匠, 小暮 真奈, 板橋 芙美, 土屋 菜歩, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 101-101 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  117. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology 31 (Suppl.) 116-116 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  118. 住環境の主観的評価と心理的苦痛との関連

    菅野 郁美, 長谷川 兼一, 中村 智洋, 土屋 菜歩, 小暮 真奈, 板橋 芙美, 成田 暁, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 143-143 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  119. 脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

    高瀬 雅仁, 中村 智洋, 平田 匠, 小暮 真奈, 板橋 芙美, 土屋 菜歩, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 101-101 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  120. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology 31 (Suppl.) 116-116 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  121. 住環境の主観的評価と心理的苦痛との関連

    菅野 郁美, 長谷川 兼一, 中村 智洋, 土屋 菜歩, 小暮 真奈, 板橋 芙美, 成田 暁, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 143-143 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  122. Effect of internet-based attention bias modification on the anxiety of Japanese workers: A randomized controlled trial. 国際誌

    Jun Tayama, Akihito Shimazu, Sayaka Ogawa, Naoki Nakaya

    Journal of occupational health 63 (1) e12229 2021年1月

    DOI: 10.1002/1348-9585.12229  

    詳細を見る 詳細を閉じる

    OBJECTIVES: This study comprised a randomized controlled trial to examine the effect of internet-based attention bias modification (iABM) on reducing workers' anxiety. METHODS: In total, 300 eligible participants were randomized according to sex and age; 180 were assigned to the intervention group and 120 to the control group. The word stimuli used in the iABM included eight positive words and eight neutral words. Participants were instructed to indicate the positive word's position as quickly and accurately as possible by tapping one of the two directions on display. The intervention included five sessions per participant over 1 month, resulting in a total of 600 trials. The main outcome measure was the total state anxiety score of the State-Trait Anxiety Inventory (STAI). RESULTS: There was no significant difference in the net change in STAI scores between the intervention and control groups. The mean reaction time of the fifth session was significantly shorter than the mean reaction time of the first session. Furthermore, although there was no effect on the index of effect size Δ, the paired t-test showed a significant decrease in the anxiety score. CONCLUSIONS: The iABM intervention in this study did not enhance the amelioration of workers' anxiety when compared with the control condition.

  123. Predictors of Early and Late Mortality after Endoscopic Resection for Esophageal Squamous Cell Carcinoma.

    Yohei Ogata, Waku Hatta, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

    The Tohoku journal of experimental medicine 253 (1) 29-39 2021年1月

    DOI: 10.1620/tjem.253.29  

    詳細を見る 詳細を閉じる

    In esophageal squamous cell carcinoma (ESCC) comprising 90% of cases with esophageal cancer, endoscopic resection (ER) is recommended for patients with negligible risk of ESCC-related mortality. In fact, a main cause of death in patients underwent ER is not ESCC. We thus aimed to clarify the predictors for early and late mortality among patients underwent ER of ESCC between 2005 and 2018 at our institution. In this retrospective cohort study, we investigated the prognosis and predictors of early and late mortality with the cut-off value of 3 years. We enrolled 407 patients with a median 69 months follow-up. The 5-year overall survival and disease-specific survival, an indicator of ESCC-related mortality, were 83.4% and 98.4%, respectively. In multivariate Cox analyses, Eastern Cooperative Oncology Group performance status (ECOG-PS), consisting of six grades by a patient's level of activity, ≥ 2 was a predictor for early and late morality [hazard ratio (HR), 7.21 (P = 0.007) and 15.62 (P = 0.021), respectively]. Charlson comorbidity index (CCI), which is an index for predicting mortality by comorbid conditions, ≥ 2 was also a predictor for both mortality [HR, 2.97 (P = 0.017) and 1.90 (P = 0.019), respectively]. However, age was a predictor only for late mortality [HR, 3.08 (P = 0.010) in 80-84 years and 8.38 (P < 0.001) in ≥ 85 years]. Considering the predictive ability for early mortality, we propose that ECOG-PS and/or CCI are better indices compared with age in deciding treatment strategy after ER for ESCC.

  124. [Advanced Gastric Cancer with Tumor Shrinkage Persisting after the Discontinuation of Nivolumab-A Case Report].

    Itaru Sato, Naoki Nakaya, Yoko Obara, Souichirou Ueno, Hideo Nakajima

    Gan to kagaku ryoho. Cancer & chemotherapy 47 (12) 1715-1717 2020年12月

    ISSN:0385-0684

    詳細を見る 詳細を閉じる

    The patient was a 65-year-old man with advanced gastric cancer, cT4bN3aM1, cStage Ⅳ. The SOX therapy was administered as the primary treatment but discontinued after 9 courses because of disease progression. The PTX plus RAM therapy was then administered for 1 courses as the secondary treatment but discontinued because of the development of peritoneal dissemination, increased number of ascites, and increased number of lymph node metastases. The nivolumab(NIV)therapy was initiated as the tertiary treatment, but the patient complained of fatigue and diplopia after 2 courses. Ptosis was observed, and transaminase and creatine kinase levels were elevated. Electrocardiography showed complete right bundle branch block. The patient showed immune-related adverse events and was diagnosed with myocarditis and myasthenia gravis due to NIV. Consequently, systemic steroids were administered. Although 2 course of CPT-11 was administered as the fourth-line treatment, the treatment was discontinued upon the patient's request. Ten months after the discontinuation of chemotherapy, the disease showed no progression. The patient is being followed-up as an outpatient. Here, we reported a case of gastric cancer with tumor shrinkage after the discontinuation of NIV.

  125. A Cross-sectional Study of Attention Bias for Facial Expression Stimulation in Patients with Stroke at the Convalescence Stage. 国際誌

    Hirokazu Takizawa, Toshiyuki Ishioka, Kohei Koizumi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Toyohiro Hamaguchi

    International journal of behavioral medicine 28 (4) 511-522 2020年12月1日

    DOI: 10.1007/s12529-020-09940-2  

    詳細を見る 詳細を閉じる

    BACKGROUND: Post-stroke depression increases the likelihood of adverse physical symptoms. Attentional bias (AB) for negative stimuli is important in depression onset, maintenance, and remission. Stroke is more likely in older adults, who can have reduced cognitive function. Individuals with mild cognitive impairment (MCI) can have delayed reaction times (RTs). We hypothesized that RT to select neutral facial expression is affected by depressive symptoms and cognitive function in patients with stroke. METHODS: This study analyzed 61 patients with stroke. Beck Depression Inventory-Second Edition (BDI-II) and Profile of Mood States (short version) scores were determined. Task stimuli comprised eight pairs of facial expressions containing affective (angry) and neutral faces. AB was measured as the RT to select the neutral face in two simultaneously presented images using attention bias modification (ABM) software. Patients were grouped according to depressive symptoms using BDI-II scores. Between-subject factors of depressive symptoms and cognitive function were determined by ANCOVA. RESULTS: No significant interaction was found between depressive symptoms and cognitive function on RT. There was a main effect of cognitive function, but not depressive symptoms. In patients with hemiparesis and depressive symptoms, RT was significantly shorter in patients without MCI compared with patients with MCI. CONCLUSIONS: People with stroke and elevated depression symptoms with hemiparesis but without MCI quickly selected neutral facial expressions from neutral and aversive expressions, and thus do not need ABM to escape aversive stimuli. ABM in response to aversive stimuli may be useful in evaluating negative emotions in individuals with post-stroke depression without MCI.

  126. Impact of the Great East Japan Earthquake on the Employment Status and Mental Health Conditions of Affected Coastal Communities. 国際誌

    Mitsuaki Katayanagi, Moe Seto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Yumi Sugawara, Akira Kodaka, Yusuke Utsumi, Hitomi Usukura, Yasuto Kunii, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    International journal of environmental research and public health 17 (21) 2020年11月3日

    DOI: 10.3390/ijerph17218130  

    詳細を見る 詳細を閉じる

    The Great East Japan Earthquake devasted the old community in coastal areas characterized by primary industry. The number of unemployed people increased from 150,000 to 190,000 after the earthquake. All of the adult residents of Shichigahama (18 years old or older), located in the coastal area of the Miyagi prefecture, whose houses were totally or majorly damaged, were recruited for a survey conducted in October 2011. All of the residents who responded with written informed consent were included in this study. Among 904 individuals who had a job before the Great East Japan Earthquake, 19% became unemployed. Concerning gender and age, 9% of young men, 34% of elderly men, 21% of young women, and 49% of elderly women became unemployed. Concerning the type of industry, 38%, 15%, and 16% of people who had belonged to the primary, secondary, and tertiary industries, respectively, before the disaster became unemployed. Those who became unemployed exhibited a significantly higher risk of insomnia compared to those who maintained jobs. The study pointed out the severe impact of the Great East Japan Earthquake on populations who had belonged to the primary industry, especially among elderly women, and its effect on sleep conditions.

  127. Trends in cancer screening rates among individuals with serious psychological distress: an analysis of data from 2007 to 2016 Japanese national surveys

    Masaki Fujiwara, Yuji Higuchi, Naoki Nakaya, Maiko Fujimori, Yuto Yamada, Riho Wada, Tsuyoshi Etoh, Kyoko Kakeda, Yosuke Uchitomi, Tomio Nakayama, Norihito Yamada, Masatoshi Inagaki

    Journal of Psychosocial Oncology Research & Practice 2 (3) e025-e025 2020年10月

    出版者・発行元:Ovid Technologies (Wolters Kluwer Health)

    DOI: 10.1097/or9.0000000000000025  

    eISSN:2637-5974

  128. 東日本大震災被災者の居住環境の変化による他者との交流習慣・メンタルヘルスへの影響

    鈴木 智美, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 中谷 直樹, 寳澤 篤, 辻 一郎, 富田 博秋

    日本公衆衛生学会総会抄録集 79回 415-415 2020年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  129. Correction: Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. 国際誌

    Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 44 (2) 262-262 2020年9月8日

    DOI: 10.1038/s41440-020-00547-4  

    詳細を見る 詳細を閉じる

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

  130. 重度の心理的苦痛を抱える人々のがん検診受診率の経時的変化 国民生活基礎調査データの解析

    藤原 雅樹, 樋口 裕二, 中谷 直樹, 藤森 麻衣子, 山田 裕士, 和田 里穂, 江藤 剛, 掛田 恭子, 内富 庸介, 中山 富雄, 山田 了士, 稲垣 正俊

    精神神経学雑誌 (2020特別号) S578-S578 2020年9月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  131. 重度の心理的苦痛を抱える人々の喫煙率の経時的変化 国民生活基礎調査データの解析

    藤原 雅樹, 樋口 裕二, 中谷 直樹, 藤森 麻衣子, 山田 裕士, 和田 里穂, 江藤 剛, 掛田 恭子, 内富 庸介, 山田 了士, 稲垣 正俊

    精神神経学雑誌 (2020特別号) S578-S578 2020年9月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  132. Reproducibility and reliability of performance indicators to evaluate the therapeutic effectiveness of biofeedback therapy after elbow surgery: An observational case series. 国際誌

    Rina Takahashi, Kazufumi Sano, Kazumasa Kimura, Toshiyuki Ishioka, Makoto Suzuki, Naoki Nakaya, Satoru Ozeki, Toyohiro Hamaguchi

    Medicine 99 (34) e21889 2020年8月21日

    DOI: 10.1097/MD.0000000000021889  

    詳細を見る 詳細を閉じる

    Electromyographic biofeedback (EMG-BF) therapy provides information on the state of contraction of the targeted muscles and relaxation of their antagonists, which can facilitate early active range of motion (RoM) after elbow surgery. Our aim in this study was to calculate the minimum detectable change (MDC) during EMG-BF therapy, initiated in the early postoperative period after elbow surgery.This study is an observational case series. EMG-BF of muscle contraction and relaxation was provided during active elbow flexion and extension exercises. Patients completed 3 sets of 10 trials each of flexion and extension over 4 weeks. The total range of flexion-extension motion and scores on the Japanese Society for Surgery of the Hand version of the disability of the arm, shoulder, and hand questionnaire and the Japanese version of the Patient-Rated Elbow Evaluation were obtained at baseline and weekly during the 4-week intervention period. A prediction formula was developed from the time-series data obtained during the intervention period, using the least-squares method. The estimated value was calculated by removing the slope from the prediction formula and adding the initial scores to residuals between the measured scores and predicted scores individually. Systematic error, MDC at the 95th percentile cutoff (MDC95), repeatability of the measures, and the change from the baseline to each time-point of intervention were assessed.The MDC95 was obtained for all 3 outcome measures and the range of values was as follows: RoM, 8.3° to 22.5°; Japanese version of the Patient-Rated Elbow Evaluation score, 17.6 to 30.6 points; and disability of the arm, shoulder, and hand questionnaire subscale: disability and symptoms score, 14.2 to 22.9 points.The efficacy of EMG-BF after elbow surgery was reflected in earlier initiation of elbow RoM after surgery and improvement in patient-reported upper limb function scores. The calculated MDC95 cut-offs could be used as reference values to assess the therapeutic effects of EMG-BF in individuals.

  133. Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. 国際誌 査読有り

    Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 44 (2) 225-231 2020年8月17日

    DOI: 10.1038/s41440-020-00536-7  

    詳細を見る 詳細を閉じる

    Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.

  134. Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease. 国際誌 査読有り

    Kazuaki Norita, Kiyotaka Asanuma, Tomoyuki Koike, Tomoki Okata, Taku Fujiya, Yasuaki Abe, Kenichiro Nakagawa, Waku Hatta, Kaname Uno, Tomohiro Nakamura, Naoki Nakaya, Naoki Asano, Akira Imatani, Tooru Shimosegawa, Atsushi Masamune

    Digestion 102 (3) 1-11 2020年8月12日

    DOI: 10.1159/000508661  

    詳細を見る 詳細を閉じる

    BACKGROUND AND OBJECTIVE: Weakly acidic reflux reaching to the proximal esophagus is closely related to the perception of gastroesophageal reflux in patients with nonerosive reflux disease despite treatment with a proton pump inhibitor (PPI). However, little is known about the involvement of the patients' mucosal integrity of the proximal esophagus. METHODS: We recruited 15 symptomatic nonerosive gastroesophageal reflux disease (GERD) patients with a positive symptom index despite PPI treatment and 11 healthy asymptomatic volunteers as controls. The biopsy specimens obtained from the proximal and distal esophagus were applied to a mini-Ussing chamber system to measure transepithelial electrical resistance (TEER) against a pH 4 weak acid. The esophageal biopsy samples were subjected to quantitative real-time PCR and immunohistochemical analysis. RESULTS: In the proximal esophagus, the weak acid exposure reduced the TEER in the PPI-refractory patients compared to that in the controls. The frequency of the reflux extending to the proximal esophagus had a significant correlation with the reduction in the proximal esophageal TEER in the patients. The reduced TEER in the proximal esophagus was accompanied by an increase in IL-8 and IL-1β mRNA and a decrease in occludin mRNA levels. The proximal esophageal mucosa in the patients presented infiltration of CD3-positive lymphocytes and an increased expression of solute carrier organic anion transporter family member 2A1 (SLCO2A1), a passage gate of reflux symptom-evoking molecules. CONCLUSIONS: The reflux perception is related to an impairment of the proximal esophageal mucosal integrity in patients with nonerosive reflux disease despite PPI.

  135. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. 国際誌 査読有り

    Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

    Pregnancy hypertension 22 119-125 2020年8月5日

    DOI: 10.1016/j.preghy.2020.08.001  

    詳細を見る 詳細を閉じる

    Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.

  136. 非喫煙者における家庭での受動喫煙と高血圧の関連 東北メディカル・メガバンク計画地域住民コホート調査より

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    厚生の指標 67 (8) 1-8 2020年8月

    出版者・発行元:(一財)厚生労働統計協会

    ISSN:0452-6104

    詳細を見る 詳細を閉じる

    目的 近年,受動喫煙が高血圧と関連することを示す疫学研究が散見されるが,関連を示さない報告もあり,一定の結論は得られていない。また,受動喫煙に関して10年前と最近1年間の受動喫煙状況を反映した検討も行われていない。そこで,本研究では非喫煙者を対象とした家庭での10年前および最近1年間における受動喫煙の組み合わせと高血圧有病との関連につき,国内の大規模コホートデータを用いた検討を行った。方法 本研究は東北メディカル・メガバンク計画地域住民コホート調査のベースライン調査データ(2013年5月〜2016年3月に実施)を用いた断面研究である。宮城県在住で同調査のベースライン調査を特定健診共同参加型で受けた非喫煙者を解析対象とし,全解析対象者を10年前と最近1年間の家庭における受動喫煙の有無の組み合わせにより4群に分類した。家庭における10年前・最近1年間の受動喫煙の組み合わせと高血圧有病との関連を多変量ロジスティック回帰分析により検討し,10年前・最近1年間ともに受動喫煙のない者を参照群とした他群の高血圧有病に対するオッズ比と95%信頼区間を算出した。結果 本研究の解析対象者は15,381名(男性2,370名,女性13,011名)であり,高血圧の有病者は5,603名(36.4%)であった。最近1年間に家庭での受動喫煙を認めた者は1,961名(12.7%)であり,そのうち1,775名(90.5%)が10年前にも家庭での受動喫煙を認めた。多変量解析の結果,10年前・最近1年間ともに家庭での受動喫煙を認める者では,10年前・最近1年間ともに家庭での受動喫煙を認めない者と比較して,年齢・BMI・飲酒歴などの高血圧の危険因子と独立し,高血圧の有病と有意な正の関連を認めた(オッズ比1.15,95%信頼区間1.02-1.29)。男女別の解析では,10年前・最近1年間ともに家庭での受動喫煙を認める女性が10年前・最近1年間ともに家庭での受動喫煙を認めない女性と比較し,高血圧の有病と有意な正の関連を認めた(オッズ比1.15,95%信頼区間1.02-1.30)。結論 非喫煙者において家庭での長期間の受動喫煙があると年齢・BMIや飲酒歴などの古典的な高血圧の危険因子と独立して高血圧の有病リスクが有意に上昇した。公衆衛生上の観点からは家庭での受動喫煙の防止が肺がん・慢性閉塞性肺疾患や虚血性心疾患等の予防だけでなく血圧値の低下にも寄与する可能性が示唆された。(著者抄録)

  137. The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study. 国際誌 査読有り

    Yusuke Utsumi, Harumi Nemoto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Tomomi Suzuki, Moe Seto, Mitsuaki Katayanagi, Junko Okuyama, Atsushi Sakuma, Nami Honda, Yumi Sugawara, Halley Kaye-Kauderer, Yuta Takahashi, Akemi Kayama, Yoshihisa Kakuto, Masahiro Kohzuki, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    Sports medicine - open 6 (1) 30-30 2020年7月16日

    DOI: 10.1186/s40798-020-00259-6  

    詳細を見る 詳細を閉じる

    BACKGROUND: In communities affected by a disaster, walking can be a feasible form of physical exercise to improve physical and mental health conditions. However, there is limited evidence to support relationships between walking habits and mental health conditions in post-disaster settings. Cross-sectional epidemiological data obtained from a questionnaire survey (conducted in October 2017) of a community affected by the 2011 Great East Japan Earthquake (GEJE) was analyzed to evaluate the relationships. METHODS: Participants included individuals over 20 years of age (N = 718) from Shichigahama town in Miyagi prefecture, whose houses were significantly damaged by the GEJE. Their mental health conditions were assessed by the Kessler Psychological Distress Scale (K6), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Impact of Event Scale-Revised (IES-R). Additionally, the questionnaire asked the participants spent duration walking on average and their walking purpose by the following items: (1) longer than 60 min per day, (2) between 30 and 60 min per day, or (3) less than 30 min per day, and whether they walked to maintain healthy living habits (health-conscious walkers) or merely for transportation without considering health consequences (non-health-conscious walkers). These information and mental health indicators were analyzed using analysis of covariance (ANCOVA). RESULTS: Among the three walking duration groups of health-conscious walkers, there were significant differences in CES-D and K6 scores (p = 0.01 and p = 0.04), but not in IES-R scores, considering age, gender, and alcohol drinking habits as covariates. CES-D score was significantly higher among short walkers (p = 0.004). Among the three walking duration groups of non-health-conscious walkers, there were significant differences in avoidance symptoms, the subdomain of IES-R (p = 0.01), but not in CES-D, K6, and total IES-R scores, considering the variants. CONCLUSION: Our study suggests that walking durations may positively affect mood, but not PTSR, only when walking is performed with the purpose of maintaining healthy living habits. Walking durations were negatively associated with avoidance symptoms among non-health-conscious walkers in the community affected by the GEJE, indicating that the disaster may have had a long-lasting impact on walking habits.

  138. Trends in smoking rates among individuals with serious psychological distress: Analysis of data from a Japanese national survey, 2007-2016. 国際誌 査読有り

    Yuji Higuchi, Masaki Fujiwara, Naoki Nakaya, Maiko Fujimori, Yuto Yamada, Riho Wada, Tsuyoshi Etoh, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Psychiatry research 291 113225-113225 2020年6月12日

    DOI: 10.1016/j.psychres.2020.113225  

    詳細を見る 詳細を閉じる

    To determine whether the downward trend in the smoking rate over time in Japan differs between individuals with and without serious psychological distress (SPD), we used nationally representative data sets from the 2007, 2010, 2013, and 2016 Comprehensive Survey of Living Conditions of Japan. SPD was defined as a score ≥ 13 on the six-item Kessler Psychological Distress Scale. We conducted multivariate logistic regression analyses including the interaction terms between SPD and survey year. A total 187,685 participants were included. The interaction terms between SPD and survey year among men were significant for 2010 and 2016 but not for 2013. Among women, the interaction terms between SPD and survey year were not significant for any year. In conclusion, we confirmed that the gap in the rate of smoking between men with SPD and those without SPD decreased from 2007 to 2016. Among women, the gap in the smoking rate between those with SPD and those without SPD remained unchanged. Our findings suggest a need for specific support strategies including pharmacological interventions, especially for women smokers with SPD. Further studies are warranted to identify factors contributing to these sex differences.

  139. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score. 国際誌 査読有り

    Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tomoyuki Koike, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribasyashi, Shu Kiyotoki, Katsuhiro Mabe, Tomohiro Nakamura, Naoki Nakaya, Mitsuhiro Fujishiro, Atsushi Masamune

    Gut 70 (3) 476-484 2020年6月4日

    DOI: 10.1136/gutjnl-2019-319926  

    詳細を見る 詳細を閉じる

    OBJECTIVE: Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC. DESIGN: This retrospective study enrolled patients who underwent ESD for EGC. Patients in the derivation cohort (n=8291) were recruited from 25 institutions, and patients in the external validation cohort (n=2029) were recruited from eight institutions in other areas. In the derivation cohort, weighted points were assigned to predictors of bleeding determined in the multivariate logistic regression analysis and a prediction model was established. External validation of the model was conducted to analyse discrimination and calibration. RESULTS: A prediction model comprised 10 variables (warfarin, direct oral anticoagulant, chronic kidney disease with haemodialysis, P2Y12 receptor antagonist, aspirin, cilostazol, tumour size >30 mm, lower-third in tumour location, presence of multiple tumours and interruption of each kind of antithrombotic agents). The rates of bleeding after ESD at low-risk (0 to 1 points), intermediate-risk (2 points), high-risk (3 to 4 points) and very high-risk (≥5 points) were 2.8%, 6.1%, 11.4% and 29.7%, respectively. In the external validation cohort, the model showed moderately good discrimination, with a c-statistic of 0.70 (95% CI, 0.64 to 0.76), and good calibration (calibration-in-the-large, 0.05; calibration slope, 1.01). CONCLUSIONS: In this nationwide multicentre study, we derived and externally validated a prediction model for bleeding after ESD. This model may be a good clinical decision-making support tool for ESD in patients with EGC.

  140. DERIVATION AND EXTERNAL VALIDATION OF A PREDICTION MODEL (BEST-J SCORE) OF BLEEDING AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER 査読有り

    Gastrointestinal Endoscopy, 91 (6) AB585-AB586 2020年6月

    DOI: 10.1016/j.gie.2020.03.3659  

  141. Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. 国際誌 査読有り

    Maiko Wagata, Mana Kogure, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Akira Narita, Hirohito Metoki, Mami Ishikuro, Masahiro Kikuya, Kozo Tanno, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Masayuki Yamamoto, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

    Hypertension research : official journal of the Japanese Society of Hypertension 43 (11) 1277-1283 2020年5月13日

    DOI: 10.1038/s41440-020-0463-8  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    We investigated whether the association between a history of hypertensive disorders of pregnancy (HDP) and hypertension in later life varies by age group and the effect of obesity on the association between a history of HDP and hypertension in later life. This cross-sectional population-based study was conducted at the Tohoku Medical Megabank Project in Miyagi and Iwate, Japan. The study subjects were 33,412 parous women of 20 years of age and older. We used multivariate logistic regression analysis to assess the association between a history of HDP and hypertension. We constructed a composite variable that combined a history of HDP (±) and overweight/obesity (BMI ≥ 25 kg/m2) (±), resulting in four categories, and analyzed the risks of each category by multivariate logistic regression analysis. In total, 1585 (4.7%) women had a history of HDP. The prevalence of hypertension was higher in women with HDP (51.4%) than in those without HDP (36.8%; p < 0.01). The adjusted odds ratios (ORs) for hypertension in women with HDP in their 30s, 40s, 50s, 60s, and 70s or older were 3.63, 1.84, 2.15, 1.48, and 1.86, respectively. In the interaction analysis, the association between a history of HDP and hypertension was stronger in women in their 30s-50s than in women who were 60 or older (p = 0.057). The adjusted ORs for hypertension were higher in overweight/obese women with HDP than in their nonoverweight/obese counterparts in all age groups (30s: 27.17 vs. 2.22; 70s: 4.75 vs. 1.90). In conclusion, the association between HDP and later hypertension was stronger in younger women and in obese women in the 30-70 age group.

  142. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌 (52) 20-20 2020年4月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  143. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌 (52) 20-20 2020年4月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  144. Relationship between calcium intake and impaired activities of daily living in a Japanese population: NIPPON DATA90. 査読有り

    Mana Kogure, Naho Tsuchiya, Akira Narita, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Atsushi Hozawa, Takehito Hayakawa, Nagako Okuda, Naoko Miyagawa, Aya Kadota, Takayoshi Ohkubo, Yoshitaka Murakami, Kiyomi Sakata, Katsuyuki Miura, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima

    Journal of epidemiology 31 (2) 119-124 2020年2月8日

    DOI: 10.2188/jea.JE20190234  

    詳細を見る 詳細を閉じる

    BACKGROUND: Major reasons for long-term care insurance certification in Japan are stroke, dementia and fracture. These diseases are reported to be associated with calcium intake. This study examined the association between calcium intake and impaired activities of daily living (ADL) using the data from NIPPON DATA90, consisting of representative sample of the Japanese population. METHODS: A population-based nested case control study was performed. A baseline survey was conducted in 1990, followed by ADL surveys of individuals ≥65 years old in 2000. Individuals with impaired ADL and selected age- and sex-matched controls were then identified. We obtained 132 pairs. Calcium intake was energy-adjusted using the residual method. The association between calcium intake and impaired ADL was examined using conditional logistic regression models. To assess the accuracy of the estimates, we conducted bootstrap analyses. RESULTS: The adjusted odds ratios (ORs) for impaired ADL compared with the group with a calcium intake of <476 mg/day were 0.72 (95% confidence interval, 95% CI: 0.37-1.40) for the 476-606 mg/day group and 0.44 (0.21-0.94) for the ≥607 mg/day group in 2000 (P for linear trend = 0.03). After the bootstrap analyses, the inverse relationship unchanged (median OR per 100-mg rise in calcium intake: 0.87 [1,000 resamplings], 95% CI: 0.76-0.97). CONCLUSIONS: After bootstrap analyses, calcium intake was inversely associated with impaired ADL, 10 years after the baseline survey.

  145. Dietary Inflammatory Index Positively Associated With High-Sensitivity C-Reactive Protein Level in Japanese From NIPPON DATA2010. 査読有り

    Yunqing Yang, Atsushi Hozawa, Mana Kogure, Akira Narita, Takumi Hirata, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Toshiharu Ninomiya, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Journal of epidemiology 30 (2) 98-107 2020年2月5日

    DOI: 10.2188/jea.JE20180156  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BACKGROUND: It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, the Dietary Inflammatory Index (DII®) was developed to assess the inflammatory potential of the overall diet. The DII has been reported as relevant to various diseases but has not been validated in Japanese. Thus, in the present study, we analyzed the relationship between DII scores and high-sensitivity C-reactive protein (hs-CRP) levels in a Japanese population. METHODS: Data of the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010), which contained 2,898 participants aged 20 years or older from the National Health and Nutrition Survey of Japan (NHNS2010), were analyzed. Nutrient intakes derived from 1-day semi-weighing dietary records were used to calculate DII scores. Energy was adjusted using the residual method. Levels of hs-CRP were evaluated using nephelometric immunoassay. Multiple linear regression analyses were performed. RESULTS: After adjusting for age, sex, smoking status, BMI, and physical activity, a significant association was observed between DII scores and log(CRP+1) (standard regression coefficient = 0.05, P < 0.01). Although it was not statistically significant, the positive association was consistently observed in almost all age-sex subgroups and the non-smoker subgroup. CONCLUSIONS: The current study confirmed that DII score was positively associated with hs-CRP in Japanese.

  146. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. 国際誌 査読有り

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    International journal of epidemiology 49 (1) 18-19 2020年2月1日

    DOI: 10.1093/ije/dyz169  

    ISSN:0300-5771

  147. Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. 査読有り

    Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

    Journal of epidemiology 31 (1) 65-76 2020年1月11日

    DOI: 10.2188/jea.JE20190271  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.

  148. Correction: The effects of locomotor activity on gastrointestinal symptoms of irritable bowel syndrome among younger people: An observational study. 国際誌

    Toyohiro Hamaguchi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Hirokazu Takizawa, Kohei Koizumi, Yoshifumi Amano, Motoyori Kanazawa, Shin Fukudo

    PloS one 15 (12) e0244465 2020年

    DOI: 10.1371/journal.pone.0244465  

    詳細を見る 詳細を閉じる

    [This corrects the article DOI: 10.1371/journal.pone.0234089.].

  149. The effects of locomotor activity on gastrointestinal symptoms of irritable bowel syndrome among younger people: An observational study. 国際誌 査読有り

    Toyohiro Hamaguchi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Hirokazu Takizawa, Kohei Koizumi, Yoshifumi Amano, Motoyori Kanazawa, Shin Fukudo

    PloS one 15 (5) e0234089 2020年

    DOI: 10.1371/journal.pone.0234089  

    詳細を見る 詳細を閉じる

    Irritable bowel syndrome (IBS) is a common bowel disorder that manifests as unexplained abdominal pain or discomfort and bowel habit changes in the form of diarrhea, constipation, or alternating patterns of the two. Some evidences demonstrate that increased physical activity improves IBS symptoms. Hence, daily exercise is recommended in these patients. In this study, we aimed to investigate the relationship between physical activity and gastrointestinal symptoms in 101 university students (female = 78) with IBS. Participants were examined by Gastrointestinal Symptoms Rating Scale (GSRS), and gait steps were measured for 1 week using a pedometer. The association between the GSRS score and pedometer counts was determined by ordinal logistic modeling analysis. The ordinal logistic regression model for GSRS and locomotor activity showed a significant stepwise fit (z = -3.05, p = 0.002). The logistic curve separated GSRS score of 5 points (moderately severe discomfort) from 2 points (minor discomfort) by locomotor activity. The probability for daily locomotor activity to discriminate between 5 and 4 points of GSRS (i.e., likely to have reverse symptoms) decreased in accordance with increment of steps per day: 78% probability for 4000 steps, 70% probability for 6000 steps, 59% probability for 8000 steps, and 48% probability for 10000 steps. This study demonstrated that the severity of GSRS is associated with the amount of walking in younger people with IBS. These results may be used as a measure to determine the daily step count to reduce the severity of gastrointestinal symptoms in individuals with IBS.

  150. Predicting recovery of upper extremity motor function after stroke according to the NovEl intervention Using Repetitive transcranial magnetic stimulation and Occupational therapy: NEURO. 査読有り

    Hamaguchi T, Abo M, Tanaka T, Murata K, Suzuki M, Nakaya N, Taguchi K

    Journal of Stroke Medicine in press 2020年

  151. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. 国際誌 査読有り

    Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 43 (1) 62-71 2020年1月

    DOI: 10.1038/s41440-019-0335-2  

    ISSN:0916-9636

    詳細を見る 詳細を閉じる

    Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, and multiple measurements of the casual urinary Na/K ratio are more strongly correlated with the 24-h urinary Na/K ratio than a single measurement. Multiple measurements of the urinary Na/K ratio might be more strongly associated with hypertension. We aimed to determine the association between multiple measurements of the casual urinary Na/K ratio and home hypertension compared with a single measurement. A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old and participated in the Tohoku Medical Megabank Project Cohort Study. We targeted 3273 subjects who borrowed home blood pressure (HBP) monitors and urinary Na/K ratio monitors for 10 consecutive days. The association between the urinary Na/K ratio and home hypertension (HBP ≥ 135/85 mmHg or under treatment for hypertension) was examined using multiple logistic regression models. To compare the prediction of home hypertension using multiple measurements with that using a single measurement, we calculated the area under the receiver operating characteristic curve (AUROC). Multiple measurements of the urinary Na/K ratio strongly related to home hypertension were better than 1 or 2 days of measurement (adjusted odds ratio of home hypertension per unit increase in urinary Na/K ratio over 6 days: 1.13-1.15). The AUROC of the urinary Na/K ratio measurement for home hypertension was stable after 5 days (AUROC = 0.779). In conclusion, multiple measurements of the urinary Na/K ratio are strongly related to home hypertension. This finding suggests that multiple measurements of the urinary Na/K ratio are useful for evaluating home hypertension.

  152. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. 国際誌 査読有り

    Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 43 (1) 23-29 2020年1月

    DOI: 10.1038/s41440-019-0329-0  

    ISSN:0916-9636

    詳細を見る 詳細を閉じる

    Few studies have reported the relationship between reduced sleep efficiency and the prevalence of hypertension independent of sleep duration in Japan. This study aimed to evaluate whether reduced sleep efficiency, measured using an objective device for >1 week, was related to an increased prevalence of hypertension independent of sleep duration in the general Japanese population. We conducted a cross-sectional study of 904 participants aged ≥20 years who lived in Miyagi Prefecture, Japan. Sleep efficiency was measured using a contactless biomotion sleep sensor for 10 continuous days. The participants were classified into two groups according to their sleep efficiency: reduced (<90%) or not reduced (≥90%). Hypertension was defined as morning home blood pressure ≥135/85 mmHg or self-reported treatment for hypertension. Multivariable logistic regression models were used to obtain odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationship between sleep efficiency and hypertension adjusted for potential confounders. The results showed that two hundred and ninety-four individuals (32.5%) had reduced sleep efficiency, and 331 (36.6%) had hypertension. Individuals with reduced sleep efficiency had a higher body mass index and shorter sleep duration. In the multivariable analysis, reduced sleep efficiency was significantly related to an increased prevalence of hypertension (OR, 1.62; 95% CI, 1.15-2.28). In conclusion, reduced sleep efficiency was significantly related to an increased prevalence of hypertension in Japanese adults. Improvements in sleep efficiency may be important to reduce blood pressure in Japanese adults.

  153. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. 国際誌 査読有り

    Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

    Disaster medicine and public health preparedness 13 (5-6) 905-911 2019年12月

    DOI: 10.1017/dmp.2019.8  

    ISSN:1935-7893

    詳細を見る 詳細を閉じる

    OBJECTIVE: We aimed to investigate the association between types of housing and allergic symptoms at 3-4 years following the Great East Japan Earthquake. METHODS: Our study was based on the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey of public school children in Miyagi Prefecture, Japan. Of the 46 648 invited schoolchildren in the 2nd to 8th grades, 9884 were included. Presence of eczema, wheezing, and mental health symptoms was defined with questionnaires. To calculate odds ratios (ORs) and 95% CIs for the associations between types of housing and eczema or respiratory symptoms, we fitted generalized linear mixed models, included a random effect for municipality of residence, and adjusted for sex, school grade, survey year, and mental health symptoms. RESULTS: Prefabricated temporary housing was significantly associated with eczema symptoms (OR, 1.46; 95% CI, 1.06-2.02). Even after adjusting for the presence of mental health symptoms, our analysis produced similar results (OR, 1.42; 95% CI, 1.03-1.96). Conversely, it was not significantly associated with respiratory symptoms (OR, 0.97; 95% CI, 0.61-1.54). CONCLUSIONS: Children living in prefabricated temporary housing had a higher prevalence of eczema symptoms; however, prevalence of respiratory symptoms was not significantly higher.

  154. Change in smoking cessation stage over 1 year in patients with schizophrenia: a follow up study in Japan. 国際誌 査読有り

    Higuchi Y, Fujiwara M, Nakaya N, Fujimori M, Hayashibara C, So R, Shinkawa I, Sato K, Yada Y, Kodama M, Takenaka H, Kishi Y, Kakeda K, Uchitomi Y, Yamada N, Inagaki M

    BMC psychiatry 19 (1) 367-367 2019年11月21日

    DOI: 10.1186/s12888-019-2351-9  

  155. A randomised controlled trial of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia in psychiatric outpatient clinics: study protocol for the J-SUPPORT 1901 (ACCESS) study. 国際誌 査読有り

    Masaki Fujiwara, Masatoshi Inagaki, Taichi Shimazu, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Kyoko Kakeda, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada

    BMJ open 9 (11) e032955 2019年11月2日

    DOI: 10.1136/bmjopen-2019-032955  

    詳細を見る 詳細を閉じる

    INTRODUCTION: One of the reasons for the high mortality rate from cancer in people with schizophrenia is delay in diagnosis. Many studies have shown lower cancer screening rates in people with schizophrenia; however, there are no interventions for people with schizophrenia to increase cancer screening. Therefore, we developed a case management (CM) intervention to encourage participation in cancer screening. The purpose of this study was to examine the efficacy of CM to encourage participation in cancer screening for people with schizophrenia, with particular focus on colorectal cancer screening by faecal occult blood testing, compared with usual intervention (UI), namely, municipal public education. METHODS AND ANALYSIS: This is an individually randomised, parallel group trial with blinded outcome assessments. The participants will be randomly allocated to either the CM plus UI group or UI alone group in a 1:1 ratio using a web-based program at a data management centre. The primary end point of the study is participation in colorectal cancer screening in the year of intervention, which will be assessed based on municipal records. ETHICS AND DISSEMINATION: This study is performed in accordance with Ethical Guidelines for Medical and Health Research Involving Human Subjects published by Japan's Ministry of Education, Science, and Technology and the Ministry of Health, Labour, and Welfare and the modified Act on the Protection of Personal Information as well as the Declaration of Helsinki. This study was approved by the institutional ethics committee at the Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences and Okayama University Hospital on 23 April 2019 (approval number: RIN1904-003). The findings of this trial will be submitted to an international peer-reviewed journal. TRIAL REGISTRATION NUMBER: UMIN000036017.

  156. Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. 国際誌 査読有り

    Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y

    Scientific reports 9 (1) 17332-17332 2019年11月

    DOI: 10.1038/s41598-019-53654-9  

  157. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  158. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  159. 遺伝因子と飲酒量の交互作用と随時血圧値の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 小暮 真奈, 田宮 元, 中村 智洋, 土屋 菜歩, 平田 匠, 丹野 高三, 清水 厚志, 菅原 準一, 栗山 進一, 辻 一郎, 木下 賢吾, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 216-216 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  160. 睡眠の測定機器から得られた睡眠状況と心理的苦痛との関連

    五十嵐 有香, 小暮 真奈, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 宮川 健, 宇留野 晃, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 223-223 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  161. 家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 223-223 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  162. 特定健康診査時に尿ナトカリ計で2年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

    小暮 真奈, 須藤 庸子, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 宮川 健, 中谷 直樹, 佐々木 秀美, 本間 洋子, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 287-287 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  163. 非喫煙者における受動喫煙の有無と家庭高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 288-288 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  164. 配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査 査読有り

    中谷 直樹, 土屋 菜歩, 成田 暁, 石黒 真美, 目時 弘仁, 平田 匠, 小暮 真奈, 中村 智洋, 後岡 広太郎, 中谷 久美, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 224-224 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  165. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連 査読有り

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  166. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査 査読有り

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  167. 非喫煙者における受動喫煙の有無と家庭高血圧の関連 査読有り

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 288-288 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  168. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. 国際誌 査読有り

    Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh, Taku Obara, Mami Ishikuro, Tomoko Kobayashi, Yayoi Aizawa, Rino Ishihara, Masayuki Yamamoto, Yoichi Suzuki

    BMC medical education 19 (1) 297-297 2019年8月2日

    DOI: 10.1186/s12909-019-1725-5  

    詳細を見る 詳細を閉じる

    BACKGROUND: Genome cohort studies are used to analyze interactions between genetic and environmental factors, providing valuable information for personalized healthcare. Large-scale and long-term cohort studies require a number of specially trained personnel, of whom those involved in obtaining informed consent play a vital role, especially during the initial phase of such studies. The Japanese Society of Human Genetics (JSHG) previously established a certification system for genome medical research coordinators (GMRCs) responsible for obtaining written consent via face-to-face explanation. Meanwhile, in the Tohoku Medical Megabank Organization (ToMMo), GMRCs are expected to play important roles not only in obtaining informed consent and conducting various assessments, but also in communicating with participants throughout the long-term follow-up. Based on the JSHG program, we therefore developed a specific education and training program for ToMMo GMRCs consisting of 17 lectures, one practical training session on the informed consent procedure, and written and interview examinations. Re-education workshops aimed at self-improvement are also carried out following certification. In this study, we evaluated the education and training program in terms of overall understanding, usefulness, and satisfaction using an anonymous questionnaire. METHODS: An anonymous questionnaire addressing each aspect of the education and training program (understanding, usefulness, and satisfaction) was distributed among 152 qualified ToMMo GMRCs. Responses were received from 94 participants (61.8%). RESULTS: There was a significant association between the level of overall understanding of lectures and medical qualification (nurse or clinical laboratory technologist), but not with age or educational background. The level of understanding and overall usefulness were lower in sessions related to genetics and epidemiology than those dealing with ToMMo practices. In the re-education workshops, GMRCs showed a preference for and hoped to learn more about both background knowledge and research progress in the ToMMo. CONCLUSIONS: The results of our questionnaire suggest that not all ToMMo GMRCs are able to understand everything during the initial education and training program, especially in terms of genomic medicine. Continuous re-education is therefore vital in improving knowledge, skills and motivation, and preparing GMRCs for a specialist role in community-based personalized healthcare.

  169. Spouse's functional disability and mortality: The Ohsaki Cohort 2006 Study. 査読有り

    Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Kumi Nakaya, Masayuki Hoshi, Ichiro Tsuji

    Geriatrics & gerontology international 19 (8) 774-779 2019年8月

    DOI: 10.1111/ggi.13709  

    ISSN:1444-1586

    詳細を見る 詳細を閉じる

    AIM: Caregiver burden is known to negatively affect a partner's health. Given the important role of physical and mental stress in mortality, a higher caregiver burden might be associated with an increased incidence of fatal events. However, previous studies of the effects of the partner's caregiving on mortality have shown inconsistent results. Thus, the purpose of the present longitudinal study was to determine if there is an association between a spouse's functional disability and mortality in the older Japanese population. METHODS: A baseline survey was carried out with 7598 participants in 2006. Information on the date of functional disability, death or emigration was retrieved from the Ohsaki City government. Functional disability was defined as receiving a certification for long-term care insurance in Japan. After a follow-up period of a maximum of 87 months, 1316 of the participants died and Cox regression analysis with adjustment for confounding factors was used to assess mortality after the incidence of functional disability in a spouse. RESULTS: The multivariate adjusted hazard ratio for mortality was 1.78 (95% confidence interval 1.52-2.08, P < 0.01) in those whose spouses had functional disabilities compared with those with spouses who did not have functional disabilities. The mortality was consistently higher, irrespective of age group or sex. CONCLUSIONS: These results imply that caregiver burden might increase stress responses and lead to increased mortality; therefore, enhancement of support systems, including long-term care, housing and livelihood support services, for those with disability and their spouses might be important for preventing deaths. Geriatr Gerontol Int 2019; 19: 774-779.

  170. Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia. 査読有り

    Hamaguchi T, Abo M, Murata K, Kenmoku M, Yoshizawa I, Ishikawa A, Suzuki M, Nakaya N, Taguchi K

    Toxins 11 (8) 2019年8月

    DOI: 10.3390/toxins11080453  

  171. Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer? 国際誌 査読有り

    Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Oka S, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Shimoda R, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Aoyagi H, Nakamura T, Nakaya N, Shimosegawa T, Masamune A

    Annals of surgical oncology 26 (11) 3636-3643 2019年7月

    DOI: 10.1245/s10434-019-07579-2  

    ISSN:1068-9265

  172. 東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

    片柳 光昭, 富田 博秋, 瀬戸 萌, 根本 晴美, 奥山 純子, 鈴木 智美, 菅原 由美, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 小高 晃, 辻 一郎, 寳澤 篤

    精神神経学雑誌 (2019特別号) S753-S753 2019年6月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  173. 精神科病院に通院中の統合失調症患者の禁煙ステージとその後の禁煙行動 アンケートによる縦断調査 査読有り

    藤原 雅樹, 樋口 裕二, 稲垣 正俊, 中谷 直樹, 藤森 麻衣子, 林原 千夏, 宋 龍平, 新川 郁太, 佐藤 康治郎, 矢田 勇慈, 児玉 匡史, 竹中 央, 来住 由樹, 掛田 恭子, 内富 庸介, 山田 了士

    精神神経学雑誌 (2019特別号) S436-S436 2019年6月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  174. 一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫, 宮崎 真理子, 寳澤 篤

    日本腎臓学会誌 61 (3) 332-332 2019年5月

    出版者・発行元:(一社)日本腎臓学会

    ISSN:0385-2385

    eISSN:1884-0728

  175. 東北メディカル・メガバンク計画 地域住民コホート 進捗と今後の展望

    寳澤 篤, 丹野 高三, 中谷 直樹, 平田 匠, 瀧 靖之, 栗山 進一, 菅原 準一, 坂田 清美, 辻 一郎, 呉 繁夫

    日本老年医学会雑誌 56 (Suppl.) 106-106 2019年5月

    出版者・発行元:(一社)日本老年医学会

    ISSN:0300-9173

  176. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing 査読有り

    Takahiro Mimori, Jun Yasuda, Yoko Kuroki, Tomoko F. Shibata, Fumiki Katsuoka, Sakae Saito, Naoki Nariai, Akira Ono, Naomi Nakai-Inagaki, Kazuharu Misawa, Keiko Tateno, Yosuke Kawai, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Kichiya Suzuki, Kengo Kinoshita, Masao Nagasaki, Masayuki Yamamoto

    The Pharmacogenomics Journal 19 (2) 136-146 2019年4月19日

    出版者・発行元:Springer Nature

    DOI: 10.1038/s41397-017-0010-4  

    ISSN:1470-269X

  177. 東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

    平田 匠, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐藤 衛, 菊谷 昌浩, 石垣 泰, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫

    糖尿病 62 (Suppl.1) S-304 2019年4月

    出版者・発行元:(一社)日本糖尿病学会

    ISSN:0021-437X

    eISSN:1881-588X

  178. Functional dyspepsiaにおけるchlorogenic acid増量かつhydroxyhydroquinone減量コーヒー飲料と通常コーヒー摂取時のディスペプシア症状ならびにglucagon-like peptide-1(GLP-1)への影響 査読有り

    庄司 知隆, 矢神 里紗, 中谷 直樹, 中村 智洋, 遠藤 由香, 佐藤 康弘, 町田 知美, 町田 貴胤, 鹿野 理子, 金澤 素, 中谷 久美, 村椿 智彦, 相澤 祐一, 小室 葉月, 佐々木 彩加, 竹下 尚男, 水野 智仁, 渡辺 卓也, 福土 審

    心身医学 59 (3) 267-267 2019年4月

    出版者・発行元:(一社)日本心身医学会

    ISSN:0385-0307

  179. Functional dyspepsiaにおけるchlorogenic acid増量かつhydroxyhydroquinone減量コーヒー飲料と通常コーヒー摂取時の味覚ならびに気分への影響 査読有り

    矢神 里紗, 庄司 知隆, 中谷 直樹, 中村 智洋, 遠藤 由香, 佐藤 康弘, 町田 知美, 町田 貴胤, 鹿野 理子, 金澤 素, 中谷 久美, 村椿 智彦, 相澤 祐一, 小室 葉月, 佐々木 彩加, 竹下 尚男, 水野 智仁, 渡辺 卓也, 福土 審

    心身医学 59 (3) 267-267 2019年4月

    出版者・発行元:(一社)日本心身医学会

    ISSN:0385-0307

  180. All-cause mortality among Japanese whose cohabiting partners are diagnosed with cancer: the Ohsaki Cohort 2006 study. 国際誌 査読有り

    Naoki Nakaya, Toshimasa Sone, Yasutake Tomata, Kumi Nakaya, Masayuki Hoshi, Ken Shimizu, Ichiro Tsuji

    Acta oncologica (Stockholm, Sweden) 58 (4) 425-431 2019年4月

    DOI: 10.1080/0284186X.2018.1562208  

    ISSN:0284-186X

    詳細を見る 詳細を閉じる

    BACKGROUND: It has been noted that not only adverse psychosocial health effects but also mortality might increase for a person living with a spouse with cancer. This study examined the association between a partner's cancer diagnosis and mortality among a Japanese population. METHODS: In December 2006, a survey was conducted on participants aged 40 years or older who were residing in northeastern Japan. We identified couples using municipality-specific household ID numbers by searching public records and confirmed partner's cancer diagnosis after the baseline measurement using regional cancer registration information. After following up for a maximum of 4.0 years with the participants regarding mortality and emigration by reviewing the Residential Registry Record, we used Cox's proportional hazards regression to estimate the hazard ratio (HR) of all-cause mortality. RESULTS: We identified 25,938 participants (12,969 pairs) and included them in the analyses. A total of 1,308 (5.0%) participants had partners with a cancer diagnosis after baseline. The study found no association between a partner's cancer diagnosis and all-cause mortality; multivariable HRs of all-cause mortality for individuals in exposed subjects compared with those in unexposed subjects were 1.35 (95% confidence interval [CI] = 0.99-1.83; p = .055). Contrarily, sensitivity analyses of mortality attributed to having partners diagnosed with cancer based on the time since entry showed that all-cause mortality significantly increased only within one year from spouse cancer diagnosis; HR = 2.18 (95% CI = 1.44-3.30; p < .01). CONCLUSIONS: Our findings reveal that the mortality rate from partner's cancer diagnosis was significantly high during the early period of diagnosis and multidisciplinary teams for cancer treatment might be important for preventing death among the partner.

  181. 成人における客観的睡眠効率と高血圧有病率との関連(Association of Objective Sleep Efficiency with Prevalence of Hypertension in Adults) 査読有り

    平田 匠, 中村 智洋, 小暮 真奈, 成田 暁, 宮川 健, 後岡 広太郎, 土屋 菜歩, 小原 拓, 中谷 直樹, 栗山 進一, 寳澤 篤

    日本循環器学会学術集会抄録集 83回 OJ22-4 2019年3月

    出版者・発行元:(一社)日本循環器学会

  182. Continuously liquid-sucking catheter attachment for the endoscope reduces the volume of liquid reflux to the mouth in esophageal endoscopic submucosal dissection. 国際誌 査読有り

    Hatta W, Koike T, Okata H, Hanzawa T, Saito M, Kondo Y, Ara N, Asanuma K, Uno K, Asano N, Imatani A, Iijima K, Nakamura T, Nakaya N, Masamune A

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 31 (5) 527-534 2019年3月

    DOI: 10.1111/den.13392  

    ISSN:0915-5635

  183. Omega-3 polyunsaturated fatty acids and psychological intervention for workers with mild to moderate depression: A double-blind randomized controlled trial. 国際誌 査読有り

    J Tayama, S Ogawa, N Nakaya, T Sone, T Hamaguchi, A Takeoka, K Hamazaki, H Okamura, J Yajima, M Kobayashi, M Hayashida, S Shirabe

    Journal of affective disorders 245 364-370 2019年2月15日

    DOI: 10.1016/j.jad.2018.11.039  

    ISSN:0165-0327

    詳細を見る 詳細を閉じる

    BACKGROUND: This study assessed whether a combined intervention of omega-3 polyunsaturated fatty acids (PUFAs) and psychoeducation better improved mild to moderate depression in workers compared to psychoeducation alone. METHODS: This study was a double-blinded, parallel group, randomized controlled trial that compared the intervention group, receiving omega-3 fatty acids, with a control group, receiving a placebo supplement. Participants receiving omega-3 fatty acids took 15 × 300 mg capsules per day for 12 weeks. The total daily dose of omega-3 PUFAs was 500 mg docosahexaenoic acid and 1000 mg eicosapentaenoic acid (EPA). The Beck Depression Inventory®-II (BDI-II) was used to assess the severity of depression after treatment. RESULTS: After 12 weeks of treatment, BDI-II scores were significantly lower in the placebo and omega-3 group, when compared to their respective baseline scores (Placebo: t = - 4.6, p < 0.01; Omega-3: t = - 7.3, p < 0.01). However, after 12 weeks of treatment, we found no significant difference between both groups with respect to changes in the BDI-II scores (0.7; 95% CI, - 0.7 to 2.1; p = 0.30). LIMITATIONS: This study did not measure blood omega-3 fatty acid concentration and presented a high-dropout rate. Moreover, our results may not be generalizable to other regions. CONCLUSIONS: The results show that a combination of omega-3 fatty acids and psychoeducation and psychoeducation alone can contribute to an improvement in symptoms in people with mild to moderate depression. However, there is no difference between the interventions in ameliorating symptoms of depression.

  184. Support vector machine-based classifier for the assessment of finger movement of stroke patients undergoing rehabilitation. 査読有り

    Hamaguchi T, Saito T, Suzuki M, Ishioka T, Tomisawa Y, Nakaya N, Abo M

    J Med Biol Eng 40 (1) in press-100 2019年

    出版者・発行元:None

    DOI: 10.1007/s40846-019-00491-w  

    ISSN:1609-0985

    eISSN:2199-4757

  185. Differences between Japan and Taiwan in the treatment of pregnant women with depressive symptoms by omega-3 fatty acids: An open-label pilot study. 国際誌 査読有り

    Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Jane Pei-Chen Chang, Yi-Ju Jill Chiang, Tai-Wei Guu, Kei Hamazaki, Naoki Nakaya, Toshimasa Sone, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J Matsuoka

    Nutritional neuroscience 22 (1) 63-71 2019年1月

    DOI: 10.1080/1028415X.2017.1354540  

    ISSN:1028-415X

    詳細を見る 詳細を閉じる

    OBJECTIVES: Although safe approaches for improving depression in pregnancy are required and the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) has been suggested, the amount of supplemental omega-3 PUFAs has varied among previous studies and adequate amount might be different among countries. The aim of this pilot study is to explore the feasibility of using 1800 mg of omega-3 PUFAs supplementation for our future double-blind, placebo-control trial, and to clarify the clinical difference and the similarity between two sites of Japan and Taiwan. METHODS: Pregnant women between 12 and 24 weeks' gestation with depressive symptoms were recruited. Participants were supplemented daily with omega-3 PUFAs capsules containing 1206 mg eicosapentaenoic acid and 609 mg docosahexaenoic acid for 12 weeks. The primary outcome was change in total score on the 17-item Hamilton Rating Scale for Depression (HAMD) at 12 weeks after supplementation. RESULTS: Eight pregnant women in Japan and five in Taiwan participated in the study. A substantial proportion of pregnant women reported high consumption of omega-3 supplements and dietary fish were excluded in Taiwan rather than in Japan sites. The decrease in HAMD score from baseline to 12 weeks after the start of the intervention was significantly larger in Japanese participants than in Taiwanese participants (Wilcoxon rank sum test; P = 0.045). DISCUSSION: The improvement of depressive symptoms was smaller at the Taiwan site than at the Japan site. Differences in psychopathology of recruited participants identified by self-rating scales might affect the degree of population heterogeneity and the treatment efficacy. A randomized-controlled trial is needed to confirm these findings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01948596.

  186. The Efficacy of Omega-3 Fatty Acids for Depressive Symptoms among Pregnant Women in Japan and Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial (SYNCHRO; NCT01948596). 国際誌 査読有り

    Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Jane Pei-Chen Chang, Yi-Ju Chiang, Hui-Ting Chen, Yu-Chuan Chien, Tai-Wei Guu, Emi Okazaki, Kei Hamazaki, Ryoko Susukida, Naoki Nakaya, Toshimasa Sone, Yo Sano, Hiroe Ito, Keiichi Isaka, Yoshiyuki Tachibana, Shinji Tanigaki, Tomo Suzuki, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J Matsuoka

    Psychotherapy and psychosomatics 88 (2) 122-124 2019年

    DOI: 10.1159/000495296  

    ISSN:0033-3190

  187. Estimation of Motor Impairment and Usage of Upper Extremities during Daily Living Activities in Poststroke Hemiparesis Patients by Observation of Time Required to Accomplish Hand Dexterity Tasks. 国際誌 査読有り

    Tanaka T, Hamaguchi T, Suzuki M, Sakamoto D, Shikano J, Nakaya N, Abo M

    BioMed research international 2019 9471921-9471921 2019年

    DOI: 10.1155/2019/9471921  

    ISSN:2314-6133

  188. Immunohistochemical pattern of c-MYC protein judged as '+/(weak)+/-' by a new notation correlates with MYC gene non-translocation in large B-cell lymphoma. 国際誌 査読有り

    Fujishima F, Katsushima H, Fukuhara N, Konosu-Fukaya S, Nakamura Y, Usubuchi H, Sato S, Ota Y, Yashima-Abo A, Nakamura T, Nakaya N, Harigae H, Sasano H, Ichinohasama R

    Human pathology 85 112-118 2018年11月

    DOI: 10.1016/j.humpath.2018.10.025  

    ISSN:0046-8177

  189. Different risk factors between early and late cancer recurrences in patients without additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer. 国際誌 査読有り

    Yamada S, Hatta W, Shimosegawa T, Takizawa K, Oyama T, Kawata N, Takahashi A, Oka S, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Nakaya N, Gotoda T

    Gastrointestinal endoscopy 89 (5) 950-960 2018年11月

    DOI: 10.1016/j.gie.2018.11.015  

    ISSN:0016-5107

  190. Smoking among adults with serious psychological distress: Analysis of anonymized data from a national cross-sectional survey in Japan. 国際誌 査読有り

    Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada

    Journal of affective disorders 239 131-137 2018年10月15日

    DOI: 10.1016/j.jad.2018.07.008  

    ISSN:0165-0327

    詳細を見る 詳細を閉じる

    BACKGROUND: Smoking behavior among people with serious psychological distress (SPD) has not been fully investigated in Asia, although smoking has become a public health concern worldwide. Many Western population-based studies indicate that people with psychological distress are more likely to smoke. METHODS: This study used a national representative data set from the 2010 Comprehensive Survey of Living Conditions of Japan. SPD was defined as scores ≥13 or greater on the Kessler Psychological Distress Scale (K6). Multivariate logistic regression analyses were conducted to analyze the association between SPD and current smoking in Japanese adults. RESULTS: In both men (n = 27,937) and women (n = 30,786), SPD was significantly associated with current smoking (adjusted odds ratios [95% confidence intervals]: 1.169 [1.030-1.328] for men and 1.677 [1.457-1.931] for women). Among men, SPD was significantly associated with current smoking only in people aged ≥50 years (1.519 [1.232-1.874]) and married (1.456 [1.228-1.728]). SPD was significantly associated with current smoking in women of all ages. SPD had a greater impact on current smoking for women aged 20-49 years than for those aged ≥50 years (1.832 [1.552-2.162] and 1.445 [1.099-1.900], respectively). LIMITATIONS: The cross-sectional design precludes assumptions about the direction of causality. In addition, smoking status was self-reported. CONCLUSIONS: SPD was significantly associated with current smoking in Japan and the association was much stronger for younger women. Clinical strategies are needed to reduce the prevalence of smoking among people with SPD to reduce excess mortality in this population.

  191. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. 国際誌 査読有り

    Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    Allergology international : official journal of the Japanese Society of Allergology 67 (4) 481-486 2018年10月

    DOI: 10.1016/j.alit.2018.02.009  

    ISSN:1323-8930

    詳細を見る 詳細を閉じる

    BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire. Clinical ranges of Strengths and Difficulties Questionnaire (SDQ) total difficulties scores and four SDQ subcategories of emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems were defined as scores ≥16, ≥5, ≥5, ≥7, and ≥5, respectively. RESULTS: The mean SDQ total difficulties score significantly increased as eczema status worsened (all P ≤ 0.004 for trend). The OR of scores in the clinical range for SDQ total difficulties were 1.51 (95% CI, 1.31-1.74) for mild/moderate eczema and 2.63 (95% CI, 1.91-3.63) for severe eczema (P < 0.001 for trend), adjusted for sex, school grade, current wheeze, and disaster-related factors, using normal eczema as a reference. The association between severity of eczema and four SDQ subcategories showed a similar trend (all P ≤ 0.017 for trend). CONCLUSIONS: We found a significant association between severity of eczema and mental health problems. The presence of eczema was associated with four SDQ subcategories.

  192. Functional disability among partners and community activity in elderly Japanese: The Ohsaki Cohort 2006 Study 査読有り

    Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Masayuki Hoshi, Ichiro Tsuji

    Archives of Gerontology and Geriatrics 78 150-154 2018年9月1日

    出版者・発行元:Elsevier Ireland Ltd

    DOI: 10.1016/j.archger.2018.06.007  

    ISSN:1872-6976 0167-4943

    eISSN:1872-6976

    詳細を見る 詳細を閉じる

    Introduction: This cross-sectional study aimed to determine association between partners’ functional disability and community activity in an elderly Japanese population. Methods: A baseline survey was conducted between December 1 st and December 15th, 2006 and included 6600 participants from whom we collected data regarding their participation in community activity and functional disability among their partners. We defined functional disability as receiving certification for long-term care insurance in Japan, and frequent community activity as engaging in community activity more than once a month. Multiple logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for frequent community activity based on functional disability among partners. We also conducted additional analyses using three types of community activities (neighborhood associations sports, exercise, or a hobby and volunteering for nonprofit organizations) as outcomes. Results: Multivariate adjusted analysis showed that the OR (95% CI) for frequent community activity was 0.70 (0.54–0.89, P &lt 0.01) among those whose partners had functional disabilities, compared with those whose partners did not have functional disabilities. This finding remained true even for different types of community activities such as neighborhood activities, sports, exercises, hobbies, and volunteering for nonprofit organizations. Conclusion: In this cross-sectional study of an elderly Japanese population, participants whose partners had functional disabilities were less likely to participate in community activity. We conclude that enhancement of support systems is important to promote participation in community activity, not only for patients with disability but their partners as well.

  193. Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake 査読有り

    Naoki Nakaya, Harumi Nemoto, Carine Yi, Ayako Sato, Kotomi Shingu, Tomoka Shoji, Shosuke Sato, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Yumi Sugawara, Zhiqian Yu, Nicole Gunawansa, Shinichi Kuriyama, Osamu Murao, Takeshi Sato, Fumihiko Imamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    International Journal of Disaster Risk Reduction 28 206-213 2018年6月1日

    出版者・発行元:Elsevier Ltd

    DOI: 10.1016/j.ijdrr.2018.02.037  

    ISSN:2212-4209

    詳細を見る 詳細を閉じる

    The effectiveness of tsunami drills in guiding evacuation behavior remains uninvestigated. Accumulation of evidence regarding the effectiveness of tsunami drills would be beneficial for improving survival and health of communities to be inundated by a tsunami. A questionnaire to inquire participants' location at the onset of the Great East Japan Earthquake and experience of the tsunami was issued as part of a survey of total adult residents of Shichigahama town whose houses were significantly damaged by the disaster. Along with the location information, self-reported information on participation in tsunami disaster drills and attendance of a lecture about tsunamis before the disaster and whether the participants evacuated after the earthquake was subjected to multiple logistic regression analyses adjusted for potential confounding factors. Amongst the 2314 participants who were present in the town at the onset of the disaster and completed the questionnaires, 1560 (67%) evacuated after the earthquake. The rate of evacuation was significantly higher amongst the population who participated in tsunami disaster drills before the event than amongst those who did not participate (multivariate-adjusted odds ratio [MOR] = 1.99, 95% confidence interval [CI] = 1.53–2.61, p &lt 0.01). However, other experience of earthquake and tsunami disaster prevention before the event did not affect evacuation behavior (MOR = 0.86–1.16). A survey of the population who survived the catastrophe provides initial evidence to advocate the administration of tsunami drills in seaside communities to enhance the evacuation behavior immediately after the disaster onset.

  194. KIWIFRUIT CAN REDUCE WHOLE GUT TRANSIT AND SYMPTOMS IN PATIENTS WITH FUNCTIONAL CONSTIPATION AND PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH CONSTIPATION 査読有り

    Okawa Yohei, Nakaya Kumi, Muratsubaki Tomohiko, Okamoto Tomoko, Fuda Mikiko, Endo Yuka, Kano Michiko, Kanazawa Motoyori, Nakaya Naoki, Barbara Giovanni, Gearry Richard B, Ansell Juliet, Kuhn-Sherlock Barbara, Drummond Lynley, Fukudo Shin

    GASTROENTEROLOGY 154 (6) S977 2018年5月

    DOI: 10.1016/S0016-5085(18)33283-9  

    ISSN:0016-5085

  195. Risk of psychological distress in partners with functional disability among older Japanese adults. 査読有り

    Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Ichiro Tsuji

    Geriatrics & gerontology international 18 (5) 775-782 2018年5月

    DOI: 10.1111/ggi.13254  

    ISSN:1444-1586

    詳細を見る 詳細を閉じる

    AIM: The present cross-sectional study aimed to evaluate the association of psychological distress with a partner's disability in an older Japanese population, as well as the effect modification of social support on this association. METHODS: The baseline survey was carried out between 1 December and 15 December 2006, and included 6809 participants from whom we collected data regarding functional disability and psychological distress. We defined functional disability as certification for long-term care insurance in Japan, and psychological distress as a Kessler 6 score of ≥10 out of 24. A multiple logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for increased psychological distress according to the categories of functional disability among partners. Stratified analyses were also carried out to investigate whether social support significantly affected the association between a partner's functional disability and psychological distress. RESULTS: The multiple-adjusted OR for psychological distress was 1.48 (95% CI 1.06-2.04) among participants whose partners had functional disabilities (vs those whose partners did not have functional disabilities). In the social support-stratified analysis, a significant association with psychological distress was observed among participants lacking social support for help with their daily housework (OR 2.47, 95% CI 1.23-4.83), but not among those with social support (OR 1.18, 95% CI 0.79-1.72); P for interaction = 0.03). CONCLUSIONS: A partner with functional disability conferred a significantly higher risk of psychological distress on older Japanese individuals, and this association was modified by social support. We conclude that social support might buffer psychological distress in this population. Geriatr Gerontol Int 2018; 18: 775-782.

  196. Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study 査読有り

    Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Tomohiro Nakamura, Naoki Nakaya, Tooru Shimosegawa

    Gastric Cancer 21 (3) 481-489 2018年5月1日

    出版者・発行元:Springer Tokyo

    DOI: 10.1007/s10120-017-0769-7  

    ISSN:1436-3305 1436-3291

    詳細を見る 詳細を閉じる

    Background: We have established a risk-scoring system, termed the “eCura system,” for the risk stratification of lymph node metastasis in patients who have received noncurative endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). We aimed to clarify whether this system contributes to the selection of patients requiring radical surgery after ESD. Methods: Between 2000 and 2011, 1,969 patients with noncurative ESD for EGC were included in this multicenter study. Depending on the treatment strategy after ESD, we had patients with no additional treatment (n = 905) and those with radical surgery after ESD (n = 1,064). After the application of the eCura system to these patients, cancer recurrence and cancer-specific mortality in each risk category of the system were compared between the two patient groups. Results: Multivariate Cox analysis revealed that in the high-risk category, cancer recurrence was significantly higher (hazard ratio = 3.13, p = 0.024) and cancer-specific mortality tended to be higher (hazard ratio = 2.66, p = 0.063) in patients with no additional treatment than in those with radical surgery after ESD, whereas no significant differences were observed in the intermediate-risk and low-risk categories. In addition, cancer-specific survival in the low-risk category was high in both patient groups (99.6 and 99.7%). A limitation of this study is that it included a small number of cases with undifferentiated-type EGC (292 cases). Conclusions: The eCura system is a useful aid for selecting the appropriate treatment strategy after noncurative ESD for EGC. However, caution is needed when applying this system to patients with undifferentiated-type EGC.

  197. 訪問・通所リハビリテーション利用者の特性と課題に関する実態調査 査読有り

    曽根稔雅, 中谷直樹, 遠又靖丈, 辻 一郎, 川越雅弘

    厚生の指標 65 (3) 1-8 2018年3月

  198. The Association between Woman's Own Birth Weight and Her Subsequent Risk for Hypertensive Disorders of Pregnancy. 査読有り

    Wagata Maiko, Tsuchiya Naho, Nakaya Naoki, Ishikuro Mami, Metoki Hirohito, Hozawa Atsushi, Kuriyama Shinichi, Yaegashi Nobuo, Sugawara Junichi

    REPRODUCTIVE SCIENCES 25 240A 2018年3月

    ISSN:1933-7191

  199. Low Cancer Screening Rates among Japanese People with Schizophrenia: A Cross-Sectional Study. 査読有り

    Masatoshi Inagaki, Masaki Fujiwara, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Chinatsu Hayashibara, Ryuhei So, Kyoko Kakeda, Masafumi Kodama, Yosuke Uchitomi, Norihito Yamada

    The Tohoku journal of experimental medicine 244 (3) 209-218 2018年3月

    DOI: 10.1620/tjem.244.209  

    ISSN:0040-8727

    詳細を見る 詳細を閉じる

    Health care disparities among people with schizophrenia is a global concern. Our previous study revealed cancer screening rates in Japanese people with schizophrenia lower than rates of approximately 40% of the general population. However, that study was based on self-reports, which can be inaccurate, and rates did not differentiate the types of cancer screening provider (i.e., municipal screening, collective opportunistic screening, and individual opportunistic screening). This study aimed to investigate records-based cancer screening rates, focusing on participation rates of people with schizophrenia who are subject to municipal cancer screening programs. We conducted a cross-sectional study at a psychiatric hospital outpatient clinic from September to November 2016. We randomly extracted 420 potential participants from among 680 eligible patients and asked them to participate. We then selected subgroups of participants living in Okayama city who were enrolled in the National Health Insurance or Public Assistance systems and were subject to colorectal, gastric, lung, breast, or cervical cancer screening provided by Okayama city (n = 97, 96, 97, 42, and 64, respectively). Participation in cancer screenings was assessed based on local government records. Municipal cancer screening rates were as follows: 13.4% (95% confidence interval: 6.6%-20.2%) for colorectal, 7.3% (2.1%-12.5%) for gastric, 16.5% (9.1%-23.9%) for lung, 21.4% (9.0%-33.8%) for breast, and 14.1% (5.6%-22.6%) for cervical cancers. The findings demonstrated extremely low cancer screening rates among people with schizophrenia subject to municipal cancer screenings in Japan. A strategy to promote municipal cancer screening for people with schizophrenia is needed.

  200. Association between serious psychological distress and nonparticipation in cancer screening and the modifying effect of socioeconomic status: Analysis of anonymized data from a national cross-sectional survey in Japan. 国際誌 査読有り

    Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada

    Cancer 124 (3) 555-562 2018年2月1日

    DOI: 10.1002/cncr.31086  

    ISSN:0008-543X

    詳細を見る 詳細を閉じる

    BACKGROUND: It is unclear whether individuals who have serious psychological distress (SPD) are less likely to participate in screening tests for gastric cancer, lung cancer, and other types of cancer. Of the few studies that have examined the association between SPD and participation in cancer screening, none have reported modifying effects of educational, marital, or employment status. METHODS: The authors analyzed a national representative data set from the 2010 Comprehensive Survey of Living Conditions of Japan., including individuals aged <69 years who met the national program criteria for each type of cancer screening (colorectal, gastric, and lung cancers, n = 29,926; breast cancer, n = 15,423; and cervical cancer, n = 24,735). SPD was defined as a score of 13 or greater on the Kessler 6 scale. Logistic regression analyses were conducted to examine the association between SPD and participation in cancer screening, and multivariate analyses stratified by socioeconomic status also were conducted. RESULTS: SPD was significantly associated with a lower odds ratio (OR) for participation in screening for colorectal cancer (OR, 0.743; 95% confidence interval [CI], 0.638-0.866), gastric cancer (OR, 0.823; 95% CI, 0.717-0.946), and lung cancer (OR, 0.691; 95% CI, 0.592-0.807). Only educational status significantly modified the effect of SPD on participation in these 3 types of cancer screening (P < .05). CONCLUSIONS: Individuals with SPD, especially those with lower education levels, were less likely to participate in screening for colorectal, gastric, and lung cancers. Individuals with SPD should be encouraged and supported to participate in cancer screening tests. Cancer 2018;124:555-62. © 2017 American Cancer Society.

  201. 東日本大震災における軽度身体的外傷と心理的苦痛の関連:七ヶ浜健康増進プロジェクト 査読有り

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生雑誌 65 (4) 157-163 2018年

    出版者・発行元:日本公衆衛生学会

    DOI: 10.11236/jph.65.4_157  

    ISSN:0546-1766

    詳細を見る 詳細を閉じる

    <p><b>目的</b> 自然災害による身体的外傷がメンタルヘルスに与える影響に関する研究はこれまでにも報告されているが,軽度の身体的外傷においてもメンタルヘルスと関連するかはほとんど検証されていない。本研究は,東日本大震災に起因する軽度身体的外傷と心理的苦痛の関連を横断研究デザインにて検討することを目的とした。</p><p><b>方法</b> 宮城県七ヶ浜町と東北大学は,共同事業「七ヶ浜健康増進プロジェクト」において,東日本大震災後の町民の健康状態や生活状況を把握するための調査を実施している。本研究では,七ヶ浜健康増進プロジェクトが大震災から約1年後に行った調査に参加し,大震災に起因する外傷およびKessler 6項目心理的苦痛尺度(以下,K6)の全設問に回答した対象者のうち,20歳以上の男女3,844人(男性1,821人/女性2,023人)を解析対象とした。心理的苦痛(K6で24点満点中13点以上を「あり」,12点以下を「なし」と定義)を目的変数,身体的外傷の有無を説明変数とし,性,年齢,社会的要因,生活習慣を調整した多変量ロジスティック回帰分析を行った。軽度身体的外傷と心理的苦痛の関連について,震災被害(近親者の喪失,人の死の目撃,家屋損壊程度)のそれぞれで層別化した解析も併せて実施した。</p><p><b>結果</b> 身体的外傷なしの群に対し,ありの群における心理的苦痛の多変量調整済みオッズ比は2.05(1.26-3.34)と有意な正の関連を示した。また,軽度身体的外傷(「擦り傷」,「切り傷・刺し傷」,「打撲・捻挫」)なしの群に対し,ありの群における心理的苦痛の多変量調整済みオッズ比は2.18(1.32-3.59)と有意な正の関連を示した。家屋損壊程度に基づく層別化解析において,家屋が半壊以下であった群では4.01(2.03-7.93)と有意な関連を示したが,大規模半壊以上の群では両者の関連は有意でなく,家屋損壊程度と軽度身体的外傷の間に有意な交互作用が示された(<i>P</i> for interaction=0.03)。</p><p><b>結論</b> 東日本大震災の甚大な被害を受けた地域住民約4,000人を対象に,大震災に起因する身体的外傷と心理的苦痛の関連を検討した。その結果,大震災に起因する軽度身体的外傷と心理的苦痛の間に有意な正の関連が認められた。心理的苦痛のハイリスク者を同定する上で,軽度身体外傷を有する者についても考慮する必要がある。</p>

  202. Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010. 査読有り

    Fujiyoshi N, Arima H, Satoh A, Ojima T, Nishi N, Okuda N, Kadota A, Ohkubo T, Hozawa A, Nakaya N, Fujiyoshi A, Okamura T, Ueshima H, Okayama A, Miura K, NIPPON DATA, Research Group

    Journal of atherosclerosis and thrombosis 25 (7) 606-620 2018年1月

    DOI: 10.5551/jat.42531  

    ISSN:1340-3478

  203. Long-term oncological outcomes of submucosal manipulation during non-curative endoscopic submucosal dissection for submucosal invasive gastric cancer: a multicenter retrospective study in Japan 査読有り

    Hirotaka Ito, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Waku Hatta, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Ryo Shimoda, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

    Surgical Endoscopy and Other Interventional Techniques 32 (1) 196-203 2018年1月1日

    出版者・発行元:Springer New York LLC

    DOI: 10.1007/s00464-017-5659-x  

    ISSN:1432-2218 0930-2794

    詳細を見る 詳細を閉じる

    Background: Sufficient information is not available on the extent to which lymph node metastasis (LNM) and prognosis are affected by submucosal manipulation during endoscopic submucosal dissection (ESD) for submucosal invasive gastric cancer (SMGC). We aimed to identify the effects of submucosal manipulation during ESD on LNM and prognosis in patients with SMGC. Methods: From 19 institutions in Japan, 2526 patients who failed to meet the current curative criteria for ESD between 2000 and 2011 were recruited. After exclusion, 1969 patients were remained. Based on the treatment strategy after ESD, 1064 patients underwent additional radical surgery. A total of 890 of 1064 patients with SMGC, LNM and cancer recurrence, and prognosis were retrospectively reviewed. Results: The median follow-up duration was 67 months. A total of 214 patients had SM1 (depth of tumor invasion from the muscularis mucosae &lt 500 μm) invasive cancer and 676 patients had SM2 (depth of tumor invasion from the muscularis mucosae ≥500 μm) invasive cancer. LNM was found in 84 patients (9.4%), and 14 patients (1.6%) developed cancer recurrence. The 3-year and 5-year overall survival rates were 96.1 and 91.7%, respectively. The 3-year and 5-year disease-specific survival rates were 99.3 and 98.5%, respectively. Conclusions: The rates of LNM and cancer recurrence, and prognosis of patients who underwent additional radical surgery after non-curative ESD for SMGC were excellent. Submucosal manipulation during ESD for SMGC does not seem to enhance the risk for LNM or worsen the prognosis compared to surgical series.

  204. Cancer screening participation in schizophrenic outpatients and the influence of their functional disability on the screening rate: A cross-sectional study in Japan 査読有り

    Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Chinatsu Hayashibara, Ryuhei So, Kyoko Kakeda, Masafumi Kodama, Yosuke Uchitomi, Norihito Yamada

    PSYCHIATRY AND CLINICAL NEUROSCIENCES 71 (12) 813-825 2017年12月

    出版者・発行元:WILEY

    DOI: 10.1111/pcn.12554  

    ISSN:1323-1316

    eISSN:1440-1819

    詳細を見る 詳細を閉じる

    Aim: The influence of schizophrenic patients' functional disability on cancer screening participation worldwide is unclear. There are few findings on the disparities in schizophrenic patients' participation in cancer screening programs in Asia. The aim of this study was to investigate the screening rate and the associations between screening and symptom severity/functional disability in patients with schizophrenia.Methods: This cross-sectional study was conducted in a psychiatric hospital outpatient clinic in Japan. We recruited schizophrenic patients meeting the national program criteria for cancer screening for colorectal, gastric, lung, breast, and cervical cancer (n = 224, 223, 224, 110, and 175, respectively). Receipt of cancer screenings was assessed using a self-report questionnaire. Scores on the modified Global Assessment of Functioning (mGAF) were evaluated by participants' primary psychiatrists.Results: Rates of cancer screenings were as follows: 24.1% for colorectal, 21.5% for gastric, 30.8% for lung, 25.5% for breast, and 19.4% for cervical cancer. A multivariable logistic analysis showed that a 1-point increase in severity/disability (100 minus mGAF score) was associated with significantly lower odds ratios (OR) for receipt of cancer screenings, except for breast cancer (OR, 0.95, 95% confidence interval [CI], 0.93-0.98 for colorectal; OR, 0.96, 95% CI, 0.93-0.98 for gastric; OR, 0.95, 95% CI, 0.93-0.97 for lung; OR, 0.97, 95% CI, 0.94-1.00 for breast; and OR, 0.95, 95% CI, 0.92-0.98 for cervical cancer).Conclusion: The findings demonstrated low rates of cancer screenings in schizophrenic patients in Japan. Our study suggests the need to encourage attendance at cancer screenings, especially in schizophrenic patients with severe symptoms/functional disability.

  205. Population-based biobank participants' preferences for receiving genetic test results 査読有り

    Kayono Yamamoto, Tsuyoshi Hachiya, Akimune Fukushima, Naoki Nakaya, Akira Okayama, Kozo Tanno, Fumie Aizawa, Tomoharu Tokutomi, Atsushi Hozawa, Atsushi Shimizu

    JOURNAL OF HUMAN GENETICS 62 (12) 1037-1048 2017年12月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/jhg.2017.81  

    ISSN:1434-5161

    eISSN:1435-232X

    詳細を見る 詳細を閉じる

    There are ongoing debates on issues relating to returning individual research results (IRRs) and incidental findings (IFs) generated by genetic research in population-based biobanks. To understand how to appropriately return genetic results from biobank studies, we surveyed preferences for returning IRRs and IFs among participants of the Tohoku Medical Megabank Project (TMM). We mailed a questionnaire to individuals enrolled in the TMM cohort study (Group 1; n=1031) and a group of Tohoku region residents (Group 2; n= 2314). The respondents were required to be over 20 years of age. Nearly 90% of Group 1 participants and over 80% of Group 2 participants expressed a preference for receiving their genetic test results. Furthermore, over 60% of both groups preferred to receive their genetic results 'from a genetic specialist.' A logistic regression analysis revealed that engaging in 'health-conscious behaviors' (such as regular physical activity, having a healthy diet, intentionally reducing alcohol intake and/ or smoking and so on) was significant, positively associated with preferring to receive their genetic test results (odds ratio=2.397 (Group 1) and 1.897 (Group 2)). Our findings provided useful information and predictors regarding the return of IRRs and IFs in a population-based biobank.

  206. Psychological Distress among Individuals Whose Partners Have Cancer 査読有り

    Naoki Nakaya, Toshimasa Sone, Kumi Nakaya, Yasutake Tomata, Atsushi Hozawa, Ichiro Tsuji

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 243 (1) 27-33 2017年9月

    出版者・発行元:TOHOKU UNIV MEDICAL PRESS

    DOI: 10.1620/tjem.243.27  

    ISSN:0040-8727

    eISSN:1349-3329

    詳細を見る 詳細を閉じる

    Cancer diagnosis influences both patients and their closest relatives. This cross-sectional study examined psychological distress among individuals whose partners had cancer in a population-based sample. Participants in the survey were citizens residing in Ohsaki City, Miyagi, Japan. Spouse pairs were identified by information of participants' relationship to the householder and address provided by municipality, and we collected self-report information on cancer history and current pain (but not the cause of pain). Psychological distress was evaluated using the Kessler 6 scale (K6). We identified 29,410 potential participants (14,705 couples), of which 23,766 (11,690 men and 12,076 women) were included in the analyses. A total of 1,374 participants (581 male and 793 female participants) had partners with history of cancer. Logistic regression analyses revealed that these participants, regardless of sex, did not show significantly higher risk of psychological distress (K6 score 13). When stratifying the analysis by partners' current pain, men whose partners had cancer and pain showed greater odds of psychological distress (odds ratio = 1.5, p = 0.04), compared with men whose partners had no cancer and had pain. However, male subjects whose partners had cancer but no pain did not show greater odds of psychological distress compared with men whose partners had no cancer and no pain. By contrast, in women whose partners had cancer, psychological distress was not associated with pain status. In conclusion, men whose partners had cancer and pain have higher risk of psychological distress, and its screening to these individuals may reduce the risk.

  207. Psychological distress in men with prostate cancer and their partners before and after cancer diagnosis: a longitudinal study 査読有り

    Akira Oba, Naoki Nakaya, Kumi Saito-Nakaya, Masaru Hasumi, Hiroyuki Takechi, Seiji Arai, Nobuaki Shimizu

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY 47 (8) 735-742 2017年8月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/jjco/hyx066  

    ISSN:0368-2811

    eISSN:1465-3621

    詳細を見る 詳細を閉じる

    Objective: To examine the relative risk of psychological distress of men with prostate cancer and their partners during the period before and after prostate cancer diagnosis compared with men without prostate cancer and their partners. Methods: The participants reported questionnaires on psychological distress at four time points: before prostate cancer biopsy, and at 1, 3 and 6 months following prostate cancer diagnosis. We performed multiple logistic regression analyses to examine the relative risk of psychological distress. Results: A total of 115 couples answered the questionnaires at all four time points. Men with prostate cancer showed a significantly higher risk of psychological distress compared to men without prostate cancer at 1 (odds ratio [OR] = 4.8, 95% confidence interval [CI] = 1.9-13.1), 3 (OR = 3.2, 95% CI = 1.1-10.2) and 6 months following prostate cancer diagnosis (OR = 6.9, 95% CI = 2.3-25.7). Their partners showed a significantly higher risk of psychological distress compared to the partners of men without prostate cancer at 1 month following prostate cancer diagnosis (OR = 2.6, 95% CI = 1.1-6.6). Conclusions: Men with prostate cancer showed psychological distress during the 6 months following the cancer diagnosis. Their partners also showed psychological distress at 1 month following the cancer diagnosis. Inviting both men with prostate cancer and their partners to speak to their concerns, empathizing with them, finding the solutions together and monitoring of their psychological status regularly should be regarded as important following prostate cancer diagnosis.

  208. Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women 査読有り

    Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 313 (1) 1007-1013 2017年7月

    出版者・発行元:AMER PHYSIOLOGICAL SOC

    DOI: 10.3945/jn.109.109314  

    ISSN:1040-0605

    eISSN:1522-1504

    詳細を見る 詳細を閉じる

    Coffee contains various compounds that have recently been reported to exert beneficial health effects. However, the conclusion of its relation with mortality has not yet been reached. In this study, we aimed to investigate the associations between coffee consumption and all-cause and cause-specific mortality in Japan. We included 37,742 participants (18,287 men and 19,455 women) aged 40-64 y without a history of cancer, myocardial infarction, or stroke at baseline in our analysis, based on the Miyagi Cohort Study initiated in 1990. The outcomes were mortality due to all causes, cardiovascular disease (CVD), and cancer. During the 10.3 y of follow-up, 2454 participants died, including 426 due to CVD and 724 due to cancer. In women, the multivariate hazard ratios (HR) (95% CI) for all-cause mortality in participants who drank coffee never, occasionally, 1-2 cups (150-300 mL)/d, and &gt;= 3 cups/d were 1.00, 0.88 (0.73-1.06), 0.82 (0.66-1.02), and 0.75 (0.53-1.05), respectively (P-trend = 0.04). For CVD mortality in women, the multivariate HR (95% CI) were 1.00, 0.56 (0.36-0.86), 0.48 (0.29-0.80), and 0.45 (0.20-1.03), respectively (P-trend = 0.006). Of the specific CVD diseases, there was a strong inverse association between coffee consumption and mortality due to coronary heart disease (CHD) in women (P-trend = 0.02) but not in men. Death due to cancer was not associated with coffee consumption in either men or women, except for colorectal cancer in women. Our results suggest that coffee may have favorable effects on morality due to all causes and to CVD, especially CHD, in women.

  209. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren 査読有り

    Miyashita M, Ishikuro M, Kikuya M, Yamanaka C, Mizuno S, Nagai M, Sato Y, Obara T, Metoki H, Kikuchi A, Nakaya N, Hozawa A, Tsuji I, Yaegashi N, Yamamoto M, Kure S, Kuriyama S

    Journal of Pediatrics and Congenital Disorders 4 101 2017年7月

  210. 精神科病院に通院中の統合失調症患者におけるがん検診受診率 アンケートによる単施設横断研究 査読有り

    藤原 雅樹, 稲垣 正俊, 中谷 直樹, 樋口 裕二, 藤森 麻衣子, 林原 千夏, 宋 龍平, 掛田 恭子, 児玉 匡史, 内富 庸介, 山田 了士

    精神神経学雑誌 (2017特別号) S291-S291 2017年6月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  211. A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: "eCura system" 査読有り

    Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

    AMERICAN JOURNAL OF GASTROENTEROLOGY 112 (6) 874-881 2017年6月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/ajg.2017.95  

    ISSN:0002-9270

    eISSN:1572-0241

    詳細を見る 詳細を閉じる

    OBJECTIVES: Although radical surgery is recommended for patients not meeting the curative criteria for endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) because of the potential risk of lymph node metastasis (LNM), this recommendation may be overestimated and excessive. We aimed to establish a simple scoring system for decision making after ESD. METHODS: This multicenter retrospective study consisted of two stages. First, the risk-scoring system for LNM was developed using multivariate logistic regression analysis in 1,101 patients who underwent radical surgery after having failed to meet the curative criteria for ESD of EGC. Next, the system was internally validated by survival analysis in another 905 patients who also did not meet the criteria and did not receive additional treatment after ESD. RESULTS: In the development stage, based on accordant regression coefficients, five risk factors for LNM were weighted with point values: three points for lymphatic invasion and 1 point each for tumor size &gt;30 mm, positive vertical margin, venous invasion, and submucosal invasion &gt;= 500 mu m. Then, the patients were categorized into three LNM risk groups: low (0-1 point: 2.5% risk), intermediate (2-4 points: 6.7%), and high (5-7 points: 22.7%). In the validation stage, cancer-specific survival differed significantly among these groups (99.6, 96.0, and 90.1%, respectively, at 5 years; P &lt; 0.001). The C statistic of the system for cancer-specific mortality was 0.78. CONCLUSIONS: This scoring system predicted cancer-specific survival in patients who did not meet the curative criteria after ESD for EGC. ESD without additional treatment may be an acceptable option for patients at low risk.

  212. Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster 査読有り

    Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS 11 (2) 179-182 2017年4月

    出版者・発行元:CAMBRIDGE UNIV PRESS

    DOI: 10.1017/dmp.2016.102  

    ISSN:1935-7893

    eISSN:1938-744X

    詳細を見る 詳細を閉じる

    Objective :This study examined the association between psychological distress and the risk of withdrawing from hypertension treatment (HTTx) 1 year after the earthquake disaster in the coastal area affected by the Great East Japan Earthquake (GEJE). Methods: Using cross-sectional data from 2012, we studied people over 20 years of age living in Shichigahama Town, Miyagi, on the northeastern coast of Japan, which had been severely inundated by the tsunami that followed the GEJE in 2011. A total of 1014 subjects were categorized as in need of HTTx. Withdrawing from HTTx was assessed by using a self-reported questionnaire. Results: Subjects with a higher degree of psychological distress (Kessler-6 [K6] score 13) exhibited a significantly higher risk of withdrawing from HTTx, compared with subjects with a lower degree of psychological distress (K6 score 12; odds ratio=4.0; 95% confidence interval: 1.3-10.6, P&lt;0.01). Conclusions: This study indicated that psychological distress is a risk factor for withdrawing from HTTx in post-disaster settings. Our data suggested that the increased risk of withdrawing from HTTx associated with post-disaster psychological distress may underlie the increased prevalence of vascular diseases after the earthquake disaster in coastal areas affected by the tsunami.

  213. The Association Between the History of Hypertensive Disorders of Pregnancy, Obesity and Hypertension in Later Life by Age Group: A Cross-Sectional Analysis. 査読有り

    Maiko Wagata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Hirohito Metoki, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

    REPRODUCTIVE SCIENCES 24 63A-63A 2017年3月

    出版者・発行元:SAGE PUBLICATIONS INC

    ISSN:1933-7191

    eISSN:1933-7205

  214. Age at first birth and long-term mortality for mothers: the Ohsaki cohort study 査読有り

    Taichi Sakai, Yumi Sugawara, Ikue Watanabe, Takashi Watanabe, Yasutake Tomata, Naoki Nakaya, Ichiro Tsuji

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 22 (1) 24 2017年

    出版者・発行元:SPRINGER

    DOI: 10.1186/s12199-017-0631-x  

    ISSN:1342-078X

    eISSN:1347-4715

    詳細を見る 詳細を閉じる

    Background: Although maternal age at first birth has been rising in many developed countries, its long-term effects on the health of the mothers themselves are unclear. In this study, we investigated the relationship between maternal age at first birth and long-term mortality. Methods: We conducted a cohort study of 20,624 parous Japanese women aged between 40 and 79 years in 1994 and followed up their survival for 14 years. Based on maternal age at first birth, the women were divided into four groups: &lt;= 19 years, 20-24 years, 25-29 years, and &gt;= 30 years. Using the 20-24 years group as a reference, hazards ratios (HRs) for all-cause and cause-specific mortality were calculated. Results: Multivariate HRs for all-cause mortality were 1.17 in the &lt;= 19 years group, 1.09 in the 25-29 years group, and 1.33 in the &gt;= 30 years group. A U-shaped relationship was apparent between maternal age at first birth and mortality. This relationship was also observed for mortality attributable to cancer, cardiovascular disease and other diseases. This U-shaped relationship was observed only for women born before 1935 and the birth year of the first child before 1960. Conclusion: A U-shaped relationship was apparent between maternal age at first birth and mortality. As maternal age at first birth is rising worldwide, the risk it imposes appears to have significance in the context of public health.

  215. The Risk Factors for Metastasis in Non-Ampullary Duodenal Neuroendocrine Tumors Measuring 20 mm or Less in Diameter 査読有り

    Waku Hatta, Tomoyuki Koike, Katsunori Iijima, Kiyotaka Asanuma, Naoki Asano, Hiroaki Musha, Yoshifumi Inomata, Toshikazu Sano, Hiroyuki Endo, Atsushi Ikehata, Toru Horii, Motoki Ohyauchi, Satoshi Yokosawa, Atsuko Kasajima, Fumiyoshi Fujishima, Hironobu Sasano, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

    DIGESTION 95 (3) 201-209 2017年

    出版者・発行元:KARGER

    DOI: 10.1159/000459619  

    ISSN:0012-2823

    eISSN:1421-9867

    詳細を見る 詳細を閉じる

    Background/Aims: The treatment strategy for non-ampullary duodenal neuroendocrine tumors (NAD-NETs) &lt;= 20 mm in diameter has not been established. In this study, we aimed to evaluate the detailed characteristics of NAD-NETs &lt;= 20 mm in diameter to clarify the risk factors of subsequent metastasis. Methods: The patients with NAD-NETs &lt;= 20 mm in diameter who had been treated at 12 institutions between 1992 and 2013 were enrolled. Clinical records were retrieved, and histopathological findings of all cases were centrally re-viewed by 2 pathologists. Results: We studied 49 patients with a mean follow-up period of 66.5 months. Thirty-five patients were initially treated with endoscopic resection (ER), and 14 with surgery. A univariate analysis revealed the ORs and 95% CIs of the risk factors for metastasis were lympho-vascular invasion (12.5 [2.01-77.9]), multiple tumors (9.75 [1.46-65.4]), a tumor size of 11-20 mm (6.67 [1.21-36.6]), and World Health Organization grade G2 (7.13 [1.16-43.9]). Five-year overall and disease- specific survival rates were 86.1 and 97.2%, respectively. Conclusion: This is the first study to demonstrate the risk factors of metastasis in NAD-NETs &lt;= 20 mm in diameter. These findings may be helpful for determining the appropriate therapeutic approach and the clinical strategy of treatment following ER. (C) 2017 S. Karger AG, Basel

  216. Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011 査読有り

    Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Jun Aida, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    PSYCHIATRY AND CLINICAL NEUROSCIENCES 71 (1) 52-60 2017年1月

    出版者・発行元:WILEY

    DOI: 10.1111/pcn.12467  

    ISSN:1323-1316

    eISSN:1440-1819

    詳細を見る 詳細を閉じる

    AimSocial capital has been considered an important factor affecting mental-health outcomes, such as psychological distress in post-disaster settings. Although disaster-related house condition and displacement could affect both social capital and psychological distress, limited studies have investigated interactions. This study aimed to examine the association between social capital and psychological distress, taking into consideration the interaction of disaster-related house condition after the Great East Japan Earthquake of 2011. MethodsUsing data from 3793 adults living in Shichigahama, Miyagi Prefecture, Japan, we examined the association between social capital measured by generalized trust and psychological distress measured by the Kessler 6 scale. We conducted stratified analysis to investigate an interaction of house destruction and displacement. Multivariate analyses taking into consideration the interaction were performed. ResultsIn the crude analysis, low social capital (odds ratio [OR] 4.46; 95% confidence interval [CI], 3.27-6.07) and large-scale house destruction (OR 1.96; 95%CI, 1.47-2.62) were significantly associated with psychological distress. Stratified analyses detected an interaction with house destruction and displacement (P for interaction = 0.04). Multivariate analysis with interaction term revealed that individuals with low social capital, large-scale house damage, and displacement were at greater risk of psychological distress, corresponding to adjusted OR of 5.78 (95%CI, 3.48-9.60). ConclusionIn the post-disaster setting, low social capital increased the risk of psychological distress, especially among individuals who had large-scale house destruction. Among the participants with severe disaster damage, high social capital would play an important role in protecting mental health.

  217. The synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs (SYNCHRO): Study protocol for a randomized controlled trial 査読有り

    Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Yi-Ju Jill Chiang, Tai-Wei Guu, Kei Hamazaki, Naoki Nakaya, Toshimasa Sone, Yo Sano, Yoshiyuki Tachibana, Hiroe Ito, Keiich Isaka, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J. Matsuoka

    BMC PSYCHIATRY 16 (1) 321 2016年9月

    出版者・発行元:BIOMED CENTRAL LTD

    DOI: 10.1186/s12888-016-1031-2  

    ISSN:1471-244X

    詳細を見る 詳細を閉じる

    Background: Maternal depression can be harmful to both mothers and their children. Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been investigated as an alternative intervention for pregnant women with depressive symptoms because of the supporting evidence from clinical trials in major depression, the safety advantage, and its anti-inflammatory and neuroplasticity effects. This study examines the efficacy of omega-3 PUFA supplementation for pregnant women with depressive symptoms in Taiwan and Japan, to provide evidence available for Asia. The rationale and protocol of this trial are reported here. Methods: The Synchronized Trial on Expectant Mothers with Depressive Symptoms by Omega-3 PUFAs (SYNCHRO) is a multicenter, double-blind, parallel group, randomized controlled trial. Participants will be randomized to either the omega-3 PUFAs arm (1,200 mg eicosapentaenoic acid and 600 mg docosahexaenoic acid daily) or placebo arm. Primary outcome is total score on the Hamilton Rating Scale for Depression (HAMD) at 12 weeks after the start of the intervention. We will randomize 56 participants to have 90 % power to detect a 4.7-point difference in mean HAMD scores with omega-3 PUFAs compared with placebo. Because seafood consumption varies across countries and this may have a major effect on the efficacy of omega-3 PUFA supplementation, 56 participants will be recruited at each site in Taiwan and Japan, for a total number of 112 participants. Secondary outcomes include depressive symptoms at 1 month after childbirth, diagnosis of major depressive disorder, changes in omega-3 PUFAs concentrations and levels of biomarkers at baseline and at 12 weeks' follow-up, and standard obstetric outcomes. Data analyses will be by intention to treat. The trial was started in June 2014 and is scheduled to end in February 2018. Discussion: The trial is expected to provide evidence that can contribute to promoting mental health among mothers and children in Asian populations.

  218. The Tohoku Medical Megabank Project: Design and Mission 査読有り

    Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

    JOURNAL OF EPIDEMIOLOGY 26 (9) 493-511 2016年9月

    出版者・発行元:ELSEVIER SCIENCE INC

    DOI: 10.2188/jea.JE20150268  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.

  219. Does the flushing response modify the relationship between alcohol intake and hypertension in the Japanese population? NIPPON DATA2010 査読有り

    Mana Kogure, Naho Tsuchiya, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naomi Miyamatsu, Hideo Tanaka, Ichiro Wakabayashi, Aya Higashiyama, Nagako Okuda, Naoyuki Takashima, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    HYPERTENSION RESEARCH 39 (9) 670-679 2016年9月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/hr.2016.46  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    The influence of alcohol intake on hypertension may vary depending on the flushing response, but this relationship has not been confirmed. The relationship between alcohol intake and hypertension was examined according to the flushing response in a representative sample of the Japanese population. Participants in the National Health and Nutrition Survey in 2010 were asked to participate in the baseline survey of NIPPON DATA2010. Here, we investigated the relationship between alcohol intake and hypertension according to the flushing response. Statistical analyses were performed in a cross-sectional manner using multiple logistic regression models after adjusting for age, body mass index, smoking status, present illness of diabetes mellitus and present illness of dyslipidemia. Of the 1139 men and 1263 women, 659 and 463, respectively, had hypertension. Among the men, alcohol intake was positively associated with hypertension, regardless of the flushing response (P for linear trend both &lt;0.05). This positive relationship was observed for both users and non-users of antihypertensive drugs. No interaction with the flushing response was observed (P for interaction=0.360). In women, although the direction differed between flushers and non-flushers, the association between alcohol intake and hypertension was not significant, regardless of flushing response. In conclusion, In Japanese men, alcohol intake was positively associated with hypertension in a manner that was not influenced by the flushing response.

  220. Partners' Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake 査読有り

    Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 239 (4) 307-314 2016年8月

    出版者・発行元:TOHOKU UNIV MEDICAL PRESS

    DOI: 10.1620/tjem.239.307  

    ISSN:0040-8727

    eISSN:1349-3329

    詳細を見る 詳細を閉じる

    Several studies have reported that not only patients with chronic diseases but also their partners are likely to face major psychosocial problems. This study examined the association between a partner's ongoing treatment for chronic disease and the risk of psychological distress after the Great East Japan Earthquake (GEJE). In 2012, a questionnaire was distributed as part of a cross-sectional study of participants aged 20 years or older living in a municipality that had been severely inundated by the tsunami following the GEJE. We identified couples using the household numbers of the municipality and collected self-reported information on ongoing chronic disease treatment for stroke, cancer, myocardial infarction, and angina. Psychological distress was evaluated using the Kessler 6 scale (K6) and was defined as a score &gt;= 5/24 points. Among 1,246 couples (2,492 participants) thus identified, 2,369 completed the K6. The number of participants whose partners were under treatment for chronic diseases was 209 (9%). Overall, participants with partners who were receiving treatment for chronic diseases (odds ratio [OR] = 1.3, 95% confidence interval [CI] = 0.95-1.8, P = 0.09) did not show a significantly higher risk of psychological distress using logistic regression analysis. Women, but not men, whose partners were receiving treatment for chronic diseases, had a higher risk of psychological distress (women: OR = 1.6, P = 0.02; men: OR = 1.0, P = 0.92). After the GEJE, only in women the presence of partners under treatment for chronic diseases appears to be a risk factor for psychological distress.

  221. Omega-3 fatty acid supplementation for expectant mothers with depressive symptoms in Japan and Taiwan: An open-label trial 査読有り

    Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Yi-Ju Jill Chiang, Tai-Wei Guu, Kei Hamazaki, Naoki Nakaya, Toshimasa Sone, Yo Sano, Hiroe Ito, Keiichi Isaka, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J. Matsuoka

    PSYCHIATRY AND CLINICAL NEUROSCIENCES 70 (6) 253-254 2016年6月

    出版者・発行元:WILEY-BLACKWELL

    DOI: 10.1111/pcn.12388  

    ISSN:1323-1316

    eISSN:1440-1819

  222. Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area 査読有り

    Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, Hirohito Metoki, Masahiro Kikuya, Naho Tsuchiya, Tomohiro Nakamura, Fuji Nagami, Shinichi Kuriyama, Atsushi Hozawa

    PREHOSPITAL AND DISASTER MEDICINE 31 (3) 330-334 2016年6月

    出版者・発行元:CAMBRIDGE UNIV PRESS

    DOI: 10.1017/S1049023X16000182  

    ISSN:1049-023X

    eISSN:1945-1938

    詳細を見る 詳細を閉じる

    Introduction: The Great East Japan Earthquake of March 11, 2011 may have influenced the long-term health of those in the disaster area. It is important to collect current and future health information of the people living in the post-disaster area to provide appropriate health support and quality-oriented care. However, public perceptions of health and genomic studies in the Great East Japan Earthquake disaster area are still unknown. Methods: A questionnaire survey was conducted in one town affected by the Great East Japan Earthquake and subsequent tsunami. The results of the questionnaire were tailed and the differences in responses to each question were assessed by sex and age. Results: In 284 eligible people (137 men, 147 women), almost all participants agreed to join a health survey investigating the adverse effects of the disaster, and over 80% of the total participants agreed to genomic analysis. Over 70% of the participants wanted to receive pharmacogenetic testing and to receive feedback on which medications were suitable or unsuitable for them. Conclusions: Most people living in the disaster area are interested in health surveys. Most of the participants also showed interest in genomic analysis.

  223. Effect of Hydroxyhydroquinone-Reduced and Chlorogenic Acids-Rich vs Usual Coffee on Symptoms and Glucagon-like Peptide-1 in Patients with Functional Dyspepsia 査読有り

    Risa Yagami, Tomotaka Shoji, Naoki Nakaya, Tomohiro Nakamura, Yuka Endo, Yasuhiro Sato, Tomomi Machida, Takatsugu Machida, Michiko Kano, Motoyori Kanazawa, Kumi Nakaya, Tomohiko Muratsubaki, Yuuichi Aizawa, Hazuki Komuro, Ayaka Sasaki, Masao Takeshita, Tomohito Mizuno, Takuya Watanabe, Shin Fukudo

    GASTROENTEROLOGY 150 (4) S352-S352 2016年4月

    出版者・発行元:W B SAUNDERS CO-ELSEVIER INC

    DOI: 10.1016/S0016-5085(16)31236-7  

    ISSN:0016-5085

    eISSN:1528-0012

  224. Long-Term Outcome and the Risk Factors for Recurrence in Patients Who Do Not Meet Current Curative Criteria of Endoscopic Submucosal Dissection for Early Gastric Cancer: A Multicenter Retrospective Study in Japan 査読有り

    Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Hiroyuki Ono, Yoshikazu Yoshifuku, Akiko Takahashi, Shu Hoteya, Masahiro Nakagawa, Koki Nakamura, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Yasumasa Hara, Ken Ohnita, Ryo Shimoda, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

    GASTROENTEROLOGY 150 (4) S868-S868 2016年4月

    出版者・発行元:W B SAUNDERS CO-ELSEVIER INC

    DOI: 10.1016/S0016-5085(16)32925-0  

    ISSN:0016-5085

    eISSN:1528-0012

  225. Prospect of future housing and risk of psychological distress at 1 year after an earthquake disaster 査読有り

    Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    PSYCHIATRY AND CLINICAL NEUROSCIENCES 70 (4) 182-189 2016年4月

    出版者・発行元:WILEY-BLACKWELL

    DOI: 10.1111/pcn.12377  

    ISSN:1323-1316

    eISSN:1440-1819

    詳細を見る 詳細を閉じる

    AimSince the Great East Japan Earthquake in 2011, many of the affected have been forced to live in temporary housing or at a relative's house. Special attention needs to be paid to the negative health impacts resulting from such changes in living conditions. This study examined the association between future housing prospects and the risk of psychological distress 1 year after the earthquake. MethodsIn 2012, a questionnaire was completed by a cross-sectional study of people aged 20 years or older living in Shichigahama Town, Miyagi, northeastern Japan, an area that had been severely inundated by the tsunami. Future housing prospects post-earthquake were classified into four categories: already settled in permanent housing, moving to new housing, under consideration, or unable to make any plans. Psychological distress was evaluated using the Kessler 6 scale, defined as 5 points out of 24. We performed multiple logistic regression analyses adjusted for potential confounding factors. ResultsOf the 3614 individuals studied, subjects whose future housing was under consideration (odds ratio [OR]=2.1, 95% confidence interval [CI]=1.6-2.7, P&lt;0.01) and those who were unable to make any future housing plans (OR=1.9, 95%CI=1.4-2.5, P&lt;0.01) exhibited a significantly higher risk of psychological distress compared with subjects who had already settled in permanent housing. ConclusionIn this study, subjects whose future housing prospects were under consideration and those who were unable to make any future housing plans were at a higher risk of psychological distress 1 year after the earthquake disaster.

  226. Longitudinal association between time-varying social isolation and psychological distress after the Great East Japan Earthquake 査読有り

    Toshimasa Sone, Naoki Nakaya, Yumi Sugawara, Yasutake Tomata, Takashi Watanabe, Ichiro Tsuji

    SOCIAL SCIENCE & MEDICINE 152 96-101 2016年3月

    出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD

    DOI: 10.1016/j.socscimed.2016.01.037  

    ISSN:0277-9536

    詳細を見る 詳細を閉じる

    Background: The association between social isolation and psychological distress among disaster survivors is inconclusive. In addition, because these previous studies were cross-sectional in design, the longitudinal association between time-varying social isolation and psychological distress was not clear. The present study examined the longitudinal association between social isolation and psychological distress after the Great East Japan Earthquake. Methods: We analyzed longitudinal data for 959 adults who had responded to the self-report questionnaires about Lubben Social Network Scale-6 (LSNS-6) and K6 in both a community-based baseline survey (2011) and a follow-up survey (2014) after the disaster. Participants were categorized into four groups according to changes in the presence of social isolation (&lt;12/30 of LSNS-6) at two time points (2011 and 2014): "remained socially isolated", "became not socially isolated", "remained not socially isolated", and "became socially isolated". We defined a K6 score of &gt;= 10/24 as indicating the presence of psychological distress. We used multiple logistic regression analysis to estimate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to indicate how the change in social isolation was related to changes in psychological distress over 3 years. Results: Among the participants who had not shown psychological distress at the baseline, the rates of deterioration of psychological distress were significantly lower in participants who "became not socially isolated" (multivariate OR = 0.26, 95% CI = 0.08-0.70) and "remained not socially isolated" (multivariate OR = 0.49, 95% CI = 0.27-0.91), compared with participants who "remained socially isolated". Among the participants who had psychological distress at the baseline, the rate of improvement of psychological distress was significantly higher in participants who "remained not socially isolated" (multivariate OR = 2.61, 95% CI = 1.08-6.44). Conclusion: The present findings suggest that prevention of social isolation may be an effective public health strategy for preventing psychological distress after a natural disaster. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

  227. Unemployment risk among individuals undergoing medical treatment for chronic diseases 査読有り

    N. Nakaya, T. Nakamura, N. Tsuchiya, I. Tsuji, A. Hozawa, H. Tomita

    OCCUPATIONAL MEDICINE-OXFORD 66 (2) 143-149 2016年3月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/occmed/kqv159  

    ISSN:0962-7480

    eISSN:1471-8405

    詳細を見る 詳細を閉じる

    Chronic diseases increase the risk of unemployment even in non-disaster settings; therefore, in post-disaster settings, special attention needs to be paid to the employment status of those suffering from chronic diseases. To examine the association between chronic disease and the risk of unemployment in a disaster area. This cross-sectional study was conducted in Shichigahama Town, Miyagi, north-eastern Japan, where had been severely inundated by the 2011 tsunami. Logistic regression analyses were used to evaluate the association between undergoing medical treatment for a combination of chronic diseases (stroke, cancer, myocardial infarction and angina) and unemployment risk. Confounders such as psychological distress and levels of daily life activity were considered. Among the 2588 individuals studied, there was a statistically significant association between undergoing medical treatment for chronic disease and the risk of unemployment [odds ratio (OR) = 1.7, 95% confidence interval (CI) 1.02-2.7, P &lt; 0.05]. In participants with a lower degree of psychological distress and better levels of daily life activity (n = 1967), no significant associations were observed (OR = 1.1, 95% CI 0.6-2.1). Conversely, in 536 participants with a higher degree of psychological distress and/or poorer levels of daily life activity, statistically significant associations were found (OR = 2.6, 95% CI 1.01-6.6, P &lt; 0.05). The association between undergoing medical treatment for chronic disease and unemployment risk was observed only in participants with a higher degree of psychological distress and/or poorer levels of daily life activity.

  228. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study 査読有り

    Masako Miyashita, Masahiro Kikuya, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Yuki Sato, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 237 (4) 297-305 2015年12月

    出版者・発行元:TOHOKU UNIV MEDICAL PRESS

    DOI: 10.1620/tjem.237.297  

    ISSN:0040-8727

    eISSN:1349-3329

    詳細を見る 詳細を閉じる

    After the Great East Japan Earthquake of 2011, there has been a concern about health problems among children. Therefore, we investigated the prevalence of wheeze and eczema symptoms and associated factors among children in areas primarily affected by the disaster. From 2012 to 2014, we distributed the parent-administered questionnaire to 25,198 children in all 233 public schools in the 13 municipalities of Miyagi Prefecture in northeast Japan. A total of 7,155 responses (mean age 10.5 +/- 2.2 years) were received (response rate: 28.4%). The prevalence of allergic symptoms according to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire in 2nd, 4th, 6th, and 8th graders was 12.4%, 9.9%, 9.3%, and 5.6% for wheeze, and 20.1%, 18.0%, 14.0%, and 12.4% for eczema. In multivariate logistic analysis, younger age, history of hospitalization, and difficulties in children's daily lives as assessed by the Strengths and Difficulties Questionnaire (SDQ), were significantly and consistently associated with both allergic symptoms (both P &lt; 0.05). Living in a coastal municipality was also associated with eczema symptoms (P = 0.0278). The prevalence of eczema symptoms in the 2nd (20.1%) and 8th (12.4%) grades was significantly higher than previously reported in Japan. Living in a coastal municipality was independently associated with eczema symptoms, and psychometric properties were also closely linked to allergic symptoms. These findings are clinically important for understanding the risks of allergic disorders after natural disasters.

  229. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals 査読有り

    Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, James Douglas Engel, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    NATURE COMMUNICATIONS 6 8018 2015年8月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/ncomms9018  

    ISSN:2041-1723

    詳細を見る 詳細を閉じる

    The Tohoku Medical Megabank Organization reports the whole-genome sequences of 1,070 healthy Japanese individuals and construction of a Japanese population reference panel (1KJPN). Here we identify through this high-coverage sequencing (32.4 x on average), 21.2 million, including 12 million novel, single-nucleotide variants (SNVs) at an estimated false discovery rate of &lt;1.0%. This detailed analysis detected signatures for purifying selection on regulatory elements as well as coding regions. We also catalogue structural variants, including 3.4 million insertions and deletions, and 25,923 genic copy-number variants. The 1KJPN was effective for imputing genotypes of the Japanese population genome wide. These data demonstrate the value of high-coverage sequencing for constructing population-specific variant panels, which covers 99.0% SNVs of minor allele frequency &gt;= 0.1%, and its value for identifying causal rare variants of complex human disease phenotypes in genetic association studies.

  230. The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project 査読有り

    Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS 9 (4) 374-381 2015年8月

    出版者・発行元:CAMBRIDGE UNIV PRESS

    DOI: 10.1017/dmp.2015.52  

    ISSN:1935-7893

    eISSN:1938-744X

    詳細を見る 詳細を閉じる

    Objective: Physical disease patients are known to experience high levels of psychological distress. This study examined the association between the medical treatment of physical diseases and psychological distress in the coastal area affected by the Great East Japan Earthquake. Methods: Using cross-sectional data, we studied 3032 individuals aged &gt;= 40 years who lived in Shichigahama, Miyagi, Japan. We examined the associations between 8 medical treatments for physical diseases and psychological distress, defined as Kessler Psychological Distress scale score &gt;= 13 of 24 points. To investigate the associations, we performed multiple logistic regression analyses. Results: There were statistically significant associations between psychological distress and medical treatments for myocardial infarction/angina pectoris (odds ratio [OR] = 1.8, 95% confidence interval [CI] = 1.0-3.0) and liver disease (OR = 3.1, 95% CI = 1.0-7.7). The other 4 medical treatments for physical diseases had ORs of 1.3 or higher and were positively associated with psychological distress: cancer, hyperlipidemia, kidney disease, and diabetes mellitus. The degree of damage to homes did not affect the association between most of the medical treatments for physical diseases and psychological distress. Conclusions: In the disaster area, most of the medical treatments for physical diseases had positive associations with psychological distress, irrespective of the degree of damage to homes.

  231. Time series analysis of gastric acid secretion over a 20-year period in normal Japanese men 査読有り

    Katsunori Iijima, Tomoyuki Koike, Yasuhiko Abe, Shuichi Ohara, Naoki Nakaya, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY 50 (8) 853-861 2015年8月

    出版者・発行元:SPRINGER JAPAN KK

    DOI: 10.1007/s00535-014-1031-2  

    ISSN:0944-1174

    eISSN:1435-5922

    詳細を見る 詳細を閉じる

    The gastric acid secretion level is an important determinant for the manifestation of the gastroesophageal reflux disease spectrum, finally leading to the development of esophageal adenocarcinoma (EAC). Although the incidence of EAC has remained low in Asia, understanding the recent trend in gastric acid secretion should be helpful in estimating future incidences of EAC in that area. We investigated the latest chronological change (1995-2014) in gastric acid secretion in normal Japanese patients. A total of 307 asymptomatic Japanese men who attended the clinic for annual endoscopic checkups from 1995 to 2014 were enrolled in this analysis. Gastrin-stimulated gastric acid secretion was estimated with the endoscopic gastrin test. The association between gastric acid secretion and chronological period was assessed with a multivariate linear regression analysis. Overall gastric acid secretion gradually increased over the 20-year period in the entire cohort in the unadjusted analysis (p &lt; 0.05). However, the apparent increase was largely related to the relative decreasing rate of H. pylori infection, which profoundly inhibited gastric acid secretion. Gastric acid secretion did not change over the 20-year period in H. pylori-negative subjects, and it showed only a mild increase during this period in H. pylori-positive subjects. Considering that gastric acid secretion remained unchanged in H. pylori-negative Japanese men over a 20-year period at a level much lower than that in Occidental subjects, upper gastrointestinal disease profiles in the Japanese population will differ from those in Western countries in the post-H. pylori era.

  232. Maladjustment to Academic Life and Employment Anxiety in University Students with Irritable Bowel Syndrome 査読有り

    Jun Tayama, Naoki Nakaya, Toyohiro Hamaguchi, Tatsuo Saigo, Atsushi Takeoka, Toshimasa Sone, Shin Fukudo, Susumu Shirabe

    PLOS ONE 10 (6) e0129345 2015年6月

    出版者・発行元:PUBLIC LIBRARY SCIENCE

    DOI: 10.1371/journal.pone.0129345  

    ISSN:1932-6203

    詳細を見る 詳細を閉じる

    The present study tested our hypothesis that university students with irritable bowel syndrome (IBS) may experience less satisfactory academic lives than those of students without IBS. We also verified the hypothesis that university students with IBS might have higher employment anxiety than students without IBS might. We conducted a cross-sectional study of 1,686 university students. Presence or absence of IBS was assessed via the Rome III Questionnaire. Two original items were used to evaluate academic life. The prevalence rates of IBS with diarrhea, IBS with constipation, mixed IBS, and unsubtyped IBS in the study population were 5%, 2%, 10%, and 3%, respectively. Regarding academic life, the proportions of participants who experienced maladjustment and employment anxiety were 29% and 50%, respectively. After adjusting for age, sex, and faculty, the odds ratios for maladjustment and employment anxiety were significantly higher in students who screened positively, relative to those who screened negatively, for IBS (OR, 1.62; 95% CI, 1.24-2.21; OR, 2.16; 95% CI, 1.68-2.81, respectively). In conclusion, maladjustment and anxiety over future employment were higher in university students with IBS relative to those without.

  233. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake 査読有り

    Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 236 (2) 123-130 2015年6月

    出版者・発行元:TOHOKU UNIV MEDICAL PRESS

    DOI: 10.1620/tjem.236.123  

    ISSN:0040-8727

    eISSN:1349-3329

    詳細を見る 詳細を閉じる

    Residents of areas affected by the Great East Japan Earthquake may suffer from diseases or health problems. We are conducting a cross-sectional study from 2012 to 2015 to investigate and address the health needs of schoolchildren affected by this disaster. In this paper, we describe the protocol and research perspectives of our long-term child health study, and present the results obtained immediately after the disaster. The parent-administered questionnaire includes the International Study of Asthma and Allergies in Childhood questionnaire for asthma and eczema symptoms, the Strengths and Difficulties Questionnaire (SDQ), and a questionnaire on influenza infection and vaccination status. In 2012, we distributed the questionnaire to 3,505 (2nd, 4th, 6th, and 8th graders) in three municipalities located in southern coastal area among the 28 municipalities, and 1,277 (36.4%) returned the completed questionnaire. Mean age was 11.1 +/- 2.2 years old. The number of children with symptoms of wheeze and eczema in the past 12 months was 146 (11.4%) and 199 (15.6%), respectively. The SDQ total difficulties score revealed 174 (13.6%) children with some form of difficulty in their daily lives. From May 2011 to April 2012, 195 (15.3%) and 649 (50.8%) children received the influenza vaccination once and twice, respectively, and 532 (41.7%) had suffered from influenza. The prevalence of eczema symptoms or some form of difficulty was higher than the Japanese average. However, careful interpretation was required because of potential self-selection bias from the low response rate. We will continue this study of schoolchildren to provide aggregate findings.

  234. Personality traits and coping styles explain anxiety in lung cancer patients to a greater extent than other factors 査読有り

    Ken Shimizu, Naoki Nakaya, Kumi Saito-Nakaya, Tatsuo Akechi, Asao Ogawa, Daisuke Fujisawa, Toshimasa Sone, Kazuhiro Yoshiuchi, Koichi Goto, Motoki Iwasaki, Shoichiro Tsugane, Yosuke Uchitomi

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY 45 (5) 456-463 2015年5月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/jjco/hyv024  

    ISSN:0368-2811

    eISSN:1465-3621

    詳細を見る 詳細を閉じる

    Objective: Although various factors thought to be correlated with anxiety in cancer patients, relative importance of each factors were unknown. We tested our hypothesis that personality traits and coping styles explain anxiety in lung cancer patients to a greater extent than other factors. Methods: A total of 1334 consecutively recruited lung cancer patients were selected, and data on cancer-related variables, demographic characteristics, health behaviors, physical symptoms and psychological factors consisting of personality traits and coping styles were obtained. The participants were divided into groups with or without a significant anxiety using the Hospital Anxiety and Depression Scale-Anxiety, and a binary logistic regression analysis was used to identify factors correlated with significant anxiety using a multivariate model. Results: Among the recruited patients, 440 (33.0%) had significant anxiety. The binary logistic regression analysis revealed a coefficient of determination (overall R-2) of 39.0%, and the explanation for psychological factors was much higher (30.7%) than those for cancer-related variables (1.1%), demographic characteristics (2.1%), health behaviors (0.8%) and physical symptoms (4.3%). Four specific factors remained significant in a multivariate model. A neurotic personality trait, a coping style of helplessness/hopelessness, and a female sex were positively correlated with significant anxiety, while a coping style of fatalism was negatively correlated. Conclusions: Our hypothesis was supported, and anxiety was strongly linked with personality trait and coping style. As a clinical implication, the use of screening instruments to identify these factors and intervention for psychological crisis may be needed.

  235. Personality and breast cancer risk and survival: the Miyagi Cohort Study 査読有り

    Yuko Minami, Toru Hosokawa, Naoki Nakaya, Yumi Sugawara, Yoshikazu Nishino, Yoichiro Kakugawa, Akira Fukao, Ichiro Tsuji

    BREAST CANCER RESEARCH AND TREATMENT 150 (3) 675-684 2015年4月

    出版者・発行元:SPRINGER

    DOI: 10.1007/s10549-015-3364-9  

    ISSN:0167-6806

    eISSN:1573-7217

    詳細を見る 詳細を閉じる

    It has long been hypothesized that personality is associated with breast cancer risk and survival. The present population-based prospective cohort study in Japan tested this hypothesis. To investigate the association of personality with breast cancer risk, a total of 15,107 women aged 40-64 years who completed the Eysenck Personality Questionnaire-Revised (EPQ-R) Short Form were followed from 1990 to 2007. To assess the association of personality with survival after breast cancer, 250 identified cases were further followed up from the date of diagnosis to 2008, and 45 all-cause deaths were documented. Study subjects were categorized into four groups based on the quartile points of scores ranging between 0 and 12 on each EPQ-R subscale (extraversion, neuroticism, psychoticism, and lie), and the hazard ratio (HR) for each category was computed using the lowest category as reference. Multivariate analysis revealed no association between any of the four personality subscales and the risk of breast cancer. In the analysis on survival, no significant association was found between any of these subscales and the risk of death, although breast cancer cases with a higher score of extraversion tended to have a lower risk of death (P for trend = 0.07; HR for highest score level = 0.38). Exclusion of 32 cases diagnosed in the first 3 years of follow-up did not largely change the results with regard to either breast cancer risk or survival. The present findings suggest that personality does not impact significantly on the development and progression of breast cancer.

  236. Prediction of Upper Limb Recovery in the Acute Phase of Cerebrovascular Disease: Evaluation of "Functional Hand'' Using the Manual Function Test 査読有り

    Toshimasa Sone, Naoki Nakaya, Kazuaki Iokawa, Keiichi Hasegawa, Tetsu Tsukada, Mariko Kaneda, Toyohiro Hamaguchi, Kenji Suzuki

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 24 (4) 815-822 2015年4月

    出版者・発行元:ELSEVIER SCIENCE BV

    DOI: 10.1016/j.jstrokecerebrovasdis.2014.11.018  

    ISSN:1052-3057

    eISSN:1532-8511

    詳細を見る 詳細を閉じる

    Background: Prediction of upper limb function recovery in the acute phase of cerebrovascular disease can help clarify goal setting in rehabilitation and subsequently shorten hospital stay. The present study aimed to develop regression equations that can be used to predict the Manual Function Test (MFT) score 3 weeks after onset and to determine the optimal cutoff MFT score for the identification of "Functional Hand.'' Methods: In all, 190 patients with cerebrovascular disease were included in this study. The baseline survey performed within 1 week after onset assessed sociodemographic profiles, medical profiles, and acute symptoms. MFT was performed to determine the cutoff score to indicate Functional Hand. We used stepwise multiple regression analysis to establish the prediction equations with the best fit for the MFT score 3 weeks after onset. In addition, the sensitivity and specificity of the MFT as an indicator of Functional Hand with cutoff values were determined. Results: The multiple regression analysis showed that the following factors had a significant influence on the MFT: Brunnstrom recovery stage, cognitive function, range of motion, age, and sensation. The area under the curve was .93 for the MFT score as an indicator of Functional Hand. The cutoff MFT score to identify Functional Hand was 22/21 points, with a sensitivity and specificity of 91.1% and 82.1%, respectively. Conclusions: Our findings helped develop regression equations that can be used to predict the MFT score 3 weeks after onset of cerebrovascular disease by evaluating factors reportedly associated with upper limb function recovery. (C) 2015 by National Stroke Association

  237. Personality and suicide risk: the impact of economic crisis in Japan 査読有り

    F. Tanji, M. Kakizaki, Y. Sugawara, I. Watanabe, N. Nakaya, Y. Minami, A. Fukao, I. Tsuji

    PSYCHOLOGICAL MEDICINE 45 (3) 559-573 2015年2月

    出版者・発行元:CAMBRIDGE UNIV PRESS

    DOI: 10.1017/S0033291714001688  

    ISSN:0033-2917

    eISSN:1469-8978

    詳細を見る 詳細を閉じる

    Background. The interactive effect of personal factors and social factors upon suicide risk is unclear. We conducted prospective cohort study to investigate whether the impact of the economic crisis in 1997-1998 upon suicide risk differed according to Neuroticism and Psychoticism personality traits. Methods. The Miyagi Cohort Study in Japan with a follow-up for 19 years from 1990 to 2008 has 29432 subjects aged 40-64 years at baseline who completed a questionnaire about various health habits and the Japanese version of the Eysenck Personality Questionnaire - Revised Short Form in 1990. Results. The suicide mortality rate increased from 4.6 per 100000 person-years before 1998 to 27.8 after 1998. Although both Neuroticism and Psychoticism were significantly associated with an increased risk of mortality during the whole period from 1990 to 2008, the impact of the economic crisis upon suicide risk differed between the Neuroticism and Psychoticism personality traits. Compared with the lowest category, the hazard ratios (HRs) for the highest Neuroticism increased from 0.66 before 1998 to 2.45 after 1998. On the other hand, the HRs for the highest Psychoticism decreased from 7.85 before 1998 to 2.05 after 1998. Conclusions. The impact of the 1997-1998 economic crisis upon suicide risk differed according to personality. Suicide risk increased among these with higher Neuroticism after the economic crisis, but this was not the case for other personality subscales.

  238. iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing. 国際誌 査読有り

    Yamaguchi-Kabata Y, Nariai N, Kawai Y, Sato Y, Kojima K, Tateno M, Katsuoka F, Yasuda J, Yamamoto M, Nagasaki M

    Human genome variation 2 15050-15050 2015年

    DOI: 10.1038/hgv.2015.50  

  239. Prediction of upper limb recovery in the acute phase of cerebrovascular disease. 査読有り

    Sone T, Nakaya N, Iokawa K, Hasegawa K, Tsukada T, Kaneda M, Hamaguchi T

    Nihon eiseigaku zasshi. Japanese journal of hygiene 70 62-68 2015年

    出版者・発行元:1

    DOI: 10.1265/jjh.70.62  

    ISSN:0021-5082

  240. Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population 査読有り

    Ikuko N Motoike, Mitsuyo Matsumoto, Inaho Danjoh, Fumiki Katsuoka, Kaname Kojima, Naoki Nariai, Yukuto Sato, Yumi Yamaguchi-Kabata, Shin Ito, Hisaaki Kudo, Ichiko Nishijima, Satoshi Nishikawa, Xiaoqing Pan, Rumiko Saito, Sakae Saito, Tomo Saito, Matsuyuki Shirota, Kaoru Tsuda, Junji Yokozawa, Kazuhiko Igarashi, Naoko Minegishi, Osamu Tanabe, Nobuo Fuse, Masao Nagasaki, Kengo Kinoshita, Jun Yasuda, Masayuki Yamamoto

    BMC Genomics 15 (1) 2014年12月

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1186/1471-2164-15-673  

    eISSN:1471-2164

  241. Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia. 国際誌

    Tohru Fujiwara, Noriko Fukuhara, Ryo Funayama, Naoki Nariai, Mayumi Kamata, Takeshi Nagashima, Kaname Kojima, Yasushi Onishi, Yoji Sasahara, Kenichi Ishizawa, Masao Nagasaki, Keiko Nakayama, Hideo Harigae

    Annals of hematology 93 (9) 1515-22 2014年9月

    DOI: 10.1007/s00277-014-2090-4  

    詳細を見る 詳細を閉じる

    Heterozygous GATA-2 germline mutations are associated with overlapping clinical manifestations termed GATA-2 deficiency, characterized by immunodeficiency and predisposition to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, there is considerable clinical heterogeneity among patients, and the molecular basis for the evolution of immunodeficiency into MDS/AML remains unknown. Thus, we conducted whole-genome sequencing on a patient with a germline GATA-2 heterozygous mutation (c. 988 C > T; p. R330X), who had a history suggestive of immunodeficiency and evolved into MDS/AML. Analysis was conducted with DNA samples from leukocytes for immunodeficiency, bone marrow mononuclear cells for MDS and bone marrow-derived mesenchymal stem cells. Whereas we did not identify a candidate genomic deletion that may contribute to the evolution into MDS, a total of 280 MDS-specific nonsynonymous single nucleotide variants were identified. By narrowing down with the single nucleotide polymorphism database, the functional missense database, and NCBI information, we finally identified three candidate mutations for EZH2, HECW2 and GATA-1, which may contribute to the evolution of the disease.

  242. Psychosocial Longitudinal Study Profile and Distress of Couples in Relation to the Conduct of Prostate Biopsy 査読有り

    Akira Oba, Naoki Nakaya, Masaru Hasumi, Kumiko Ono-Yanaba, Kumi Saito-Nakaya, Hiroyuki Takechi, Seiji Arai, Nobuaki Shimizu

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY 44 (5) 463-471 2014年5月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/jjco/hyu022  

    ISSN:0368-2811

    eISSN:1465-3621

    詳細を見る 詳細を閉じる

    Objective: Partners of prostate cancer patients have been reported to suffer from high levels of psychological distress, although there are few reports of the changes in their distress levels observed before and after the diagnosis and the factors influencing them. This study constructed a longitudinal psychosocial database of prostate cancer biopsy subjects and their partners. This paper describes a summary of the database and the nature and severity of the psychological distress and cancer-related worry. Methods: We distributed self-administered questionnaires to subjects scheduled for a prostate cancer biopsy and their partners on four occasions: prior to the biopsy, and 1, 3 and 6 months after being informed whether the diagnosis was cancer or not. The questionnaires included questions pertaining to the psychological distress, cancer-related worry and correlational factors. Results: Of the 240 couples who agreed to participate in the database project, 184 couples completed the first and second surveys; thus, the database consists of them. While no significant differences in the levels of psychological distress were found among the participants before the biopsy, the prostate cancer patients and their partners had significantly higher levels of psychological distress as compared with the non-prostate cancer patients at 1 month after being informed whether the diagnosis was cancer or not. Conclusions: This study constructed a longitudinal psychosocial database of prostate cancer biopsy subjects and their partners. Our findings suggest that partners of prostate cancer patients might experience a similar psychological impact to the prostate cancer patients before and after the diagnosis.

  243. Gastrointestinal specific anxiety in irritable bowel syndrome: Validation of the Japanese version of the visceral sensitivity index for university students 査読有り

    Tatsuo Saigo, Jun Tayama, Toyohiro Hamaguchi, Naoki Nakaya, Tadaaki Tomiie, Peter J. Bernick, Motoyori Kanazawa, Jennifer S. Labus, Bruce D. Naliboff, Susumu Shirabe, Shin Fukudo

    BioPsychoSocial Medicine 8 (1) 10 2014年3月21日

    出版者・発行元:1

    DOI: 10.1186/1751-0759-8-10  

    eISSN:1751-0759

    詳細を見る 詳細を閉じる

    Objective: The visceral sensitivity index (VSI) is a useful self-report measure of the gastrointestinal symptom-specific anxiety (GSA) of patients with irritable bowel syndrome (IBS). Previous research has shown that worsening GSA in IBS patients is related to the severity of GI symptoms, suggesting that GSA is an important endpoint for intervention. However, there is currently no Japanese version of the VSI. We therefore translated the VSI into Japanese (VSI-J) and verified its reliability and validity.Material and methods: Participants were 349 university students aged 18 and 19 years and recruited from an academic class. We analyzed data from the VSI-J, Anxiety Sensitivity Index (ASI), Hospital Anxiety and Depression scale (HAD), and Irritable Bowel Syndrome Severity Index (IBS-SI). The internal consistency, stability, and factor structure of the VSI-J and its associations with anxiety, depression and severity measures were investigated.Results: The factor structure of the VSI-J is unidimensional and similar to that of the original VSI (Cronbach's α = 0.93). Construct validity was demonstrated by significant correlations with ASI (r = 0.43, p < 0.0001), HAD-ANX (r = 0.19, p = 0.0003), and IBS-SI scores (r = 0.45, p < 0.0001). Furthermore, the VSI-J was a significant predictor of severity scores on the IBS-SI and demonstrated good discriminant (p < 0.0001) and incremental (p < 0.0001) validity.Conclusion: These findings suggest that the VSI-J is a reliable and valid measure of visceral sensitivity. © 2014 Saigo et al.; licensee BioMed Central Ltd.

  244. The association between self-reported history of physical diseases and psychological distress in a community-dwelling Japanese population: the Ohsaki Cohort 2006 Study 査読有り

    Naoki Nakaya, Mana Kogure, Kumi Saito-Nakaya, Yasutake Tomata, Toshimasa Sone, Masako Kakizaki, Ichiro Tsuji

    EUROPEAN JOURNAL OF PUBLIC HEALTH 24 (1) 45-49 2014年2月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/eurpub/ckt017  

    ISSN:1101-1262

    eISSN:1464-360X

    詳細を見る 詳細を閉じる

    Background: Patients with physical disease are known to suffer considerable psychological distress. Social support may confound the association between physical disease and psychological distress. Population-based epidemiological studies have not been conducted on the association between history of physical disease, psychological distress and social support. Methods: Using cross-sectional data from 2006, we studied 43 487 community-dwelling people aged epsilon 40 years living in Japan. We examined the association between 13 self-reported histories of physical disease and psychological distress evaluated using the Kessler 6-item psychological distress scale (K6), defined as epsilon 13 points out of 24. To investigate the association, we performed multiple logistic regression analyses adjusted for age, gender, social support and possible confounders. Social support, as the interaction between physical disease and psychological depression, was tested through the addition of cross-product terms to the multivariate-adjusted model. Results: The following histories of physical disease were found significantly and positively associated with psychological distress: cancer, diabetes mellitus, hyperlipidemia, hypertension, myocardial infarction, stroke, gastric or duodenal ulcer, liver disease, arthritis, osteoporosis, kidney disease and fall or fracture (odds ratio, 1.2-2.3). Social support did not modify the association between most histories of physical disease and psychological distress. Conclusions: Subjects with a history of physical disease were significantly and positively associated with psychological distress, and social support did not modify this association for most physical diseases. Even after patients have left hospital following treatment for physical disease, they require continuous monitoring for psychological distress by doctors and paramedics.

  245. QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究 がんリハビリテーションプログラムの開発

    岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 中谷直樹, 永田友美, 並木あかね, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

    QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究 平成25年度 総括・分担研究報告書 52-54 2014年

  246. 肺がん患者に合併する抑うつの危険因子 大規模データベースを用いた身体・心理・社会的要因の包括的検討

    清水 研, 中谷 直樹, 中谷 久美, 明智 龍男, 山田 祐, 藤森 麻衣子, 小川 朝生, 藤澤 大介, 後藤 功一, 津金 昌一郎, 岩崎 基, 内富 庸介

    総合病院精神医学 26 (1) 58-68 2014年1月

    出版者・発行元:(一社)日本総合病院精神医学会

    ISSN:0915-5872

    詳細を見る 詳細を閉じる

    肺がん患者に合併する抑うつの関連要因に関する包括的な検討を、特に心理変数に着目して行った。国立がん研究センターにおいて行われた肺癌データベースプロジェクトのデータを用いて分析を行った。1334人の対象を得ることができた。性別、年齢、身体活動度、がんの病期に関して比較をしたが、有意差はなかった。心理変数として性格特性についてEysenck Personality Questionnare-Revised(EPQ-R)の日本語版、コーピング様式としてMental Adjustment to Cancer Scale(MAC)尺度を用いた。分析の結果、肺がん告知後に12.4%の患者が抑うつを呈していたことが明らかになった。説明変数から、がん関連要因、個人要因、健康関連行動、身体症状の影響は比較的小さく、圧倒的に心理変数の関連が抑うつに強く関連していた。抑うつ群は、性格特性のうち、内向性、神経性傾向が強かった。また、コーピング様式のうち、fighting spiritが低い傾向があり、helpless/hopelessなどが高い傾向があった。

  247. Effect of Psychosocial Factors on Cancer Risk and Survival 査読有り

    Naoki Nakaya

    JOURNAL OF EPIDEMIOLOGY 24 (1) 1-6 2014年1月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.JE20130124  

    ISSN:0917-5040

    eISSN:1349-9092

    詳細を見る 詳細を閉じる

    Psychosocial factors such as personality traits and depression may alter immune and endocrine function, with possible effects on cancer incidence and survival. Although these factors have been extensively studied as risk and prognostic factors for cancer, the associations remain unclear. The author used data from prospective cohort studies in population-based and clinical databases to investigate these relations. The findings do not support the hypotheses that personality traits and depression are direct risk factors for cancer and cancer survival. Some researchers have recently reported that cancer affects the psychological status of the partners and family members of cancer patients. The mechanisms underlying this hypothesis imply the existence of not only psychological distress from caregiving and grief but also a shared unhealthy lifestyle. Only a few studies have suggested that major psychosocial problems develop in partners of cancer patients. The present study used nationwide population-based data to investigate depression risk among male partners of women with breast cancer. The results support the hypothesis that such men are at increased risk of depression. In conclusion, the effects of personality traits and depression on cancer risk and survival appear to be extremely small. In addition, partners of cancer patients were at increased risk of depression. Screening partners and family members of cancer patients for depressive symptoms is therefore an important concern for research in psycho-oncology.

  248. Relationship Between Serum Isoflavone Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: Nested Case-Control Study of the Tsurugaya Project 査読有り

    Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 68 (4) 465-472 2013年4月

    出版者・発行元:OXFORD UNIV PRESS INC

    DOI: 10.1093/gerona/gls198  

    ISSN:1079-5006

    詳細を見る 詳細を閉じる

    The longer healthy life expectancy observed in Japan may be partly attributed to the Japanese diet. The researchers sought to examine whether serum isoflavone levels are associated with disability and death. The researchers used a nested casecontrol study to compare serum isoflavones (daidzein, genistein, glycitein, and equol) levels between 165 participants that died or were certificated as disabled (cases) and 177 controls. Disability was defined by certification of long-term care insurance. Conditional logistic regression models were used to calculate the risk of isoflavones for the composite outcome. The proportion of cases was lower in the group with the highest levels of equol (34/91, 37%) compared with equol nonproducers (84/161, 52%). The risk of disability or death among equol producers remained reduced after adjusting for age and sex (odds ratio: 0.55, 95% confidence interval: 0.330.93). In a multivariate model, this risk was also unchanged (odds ratio: 0.51, 95% confidence interval: 0.270.96). There were no significant associations between daidzein, genistein, and glycitein with the composite endpoint. Higher serum equol levels, but not any other isoflavones, were inversely associated with the composite endpoint of disability and death. Although it cannot be concluded that equol per se has preventive effects on disability or death, higher equol levels appear associated with better health.

  249. Long sleep duration and cause-specific mortality according to physical function and self-rated health: the Ohsaki Cohort Study 査読有り

    Masako Kakizaki, Shinichi Kuriyama, Naoki Nakaya, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Shin Fukudo, Ichiro Tsuji

    JOURNAL OF SLEEP RESEARCH 22 (2) 209-216 2013年4月

    出版者・発行元:WILEY-BLACKWELL

    DOI: 10.1111/j.1365-2869.2012.01053.x  

    ISSN:0962-1105

    詳細を見る 詳細を閉じる

    Although several studies have examined the association between sleep duration and all-cause or cause-specific mortality, it is unclear whether long sleep duration might merely reflect decreased physical strength and poorer health status. We therefore examined the association between sleep duration and all-cause and cause-specific mortality, and conducted stratified analysis based on physical function and self-rated health. This study used prospective data from the Ohsaki Cohort Study, conducted in Miyagi Prefecture, in northern Japan. This study population comprised 49256 subjects aged 4079years at the baseline survey. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause and cause-specific mortality according to the five categories of sleep duration (6, 7, 8, 9, 10hday1), treating 7h as the reference group, employing Cox's proportional hazard regression analysis. We found that long sleep duration was associated with mortality. The HRs (95% CIs) of subjects who slept more than 10h were 1.37 (1.271.47), 1.49 (1.301.71) and 1.53 (1.361.73) for mortality due to all causes, total cardiovascular disease and other causes of death mortality, respectively. The association between long sleep duration and stroke mortality was especially marked among subjects with limited physical function and poorer health status. However, we did not observe such a trend for mortality due to all causes, total cardiovascular disease, ischaemic heart disease, cancer or other causes of death. We conclude that, with the exception of stroke mortality, the association between long sleep duration and mortality is not modified by physical function or health status.

  250. Systematic review of rehabilitation intervention in palliative care for cancer patients. 査読有り

    Abe K, Nakaya N, Sone T, Hamaguchi T, Sakai T, Sato D, Okamura H

    J Palliat Care Med 2 (131) 2013年2月

  251. QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究 がんリハビリテーションプログラムの開発

    岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 中谷直樹, 永田友美, 並木あかね, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

    QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究 平成24年度 総括・分担研究報告書 49-52 2013年

  252. 介護予防サービス利用者における生活機能の予後予測及び効果的な運動器の機能向上プログラムの実施内容に対する評価 査読有り

    曽根稔雅, 中谷直樹, 遠又靖丈, 相田潤, 大久保一郎, 大原里子, 大渕修一, 杉山みち子, 安村誠司, 鈴木隆雄, 辻一郎

    日本衛生学雑誌 68 (1) 11-21 2013年1月

  253. [Prognostic prediction of the functional capacity and effectiveness of functional improvement program of the musculoskeletal system among users of preventive care service under long-term care insurance]. 査読有り

    Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Jun Aida, Ichiro Okubo, Satoko Ohara, Shuichi Obuchi, Michiko Sugiyama, Seiji Yasumura, Takao Suzuki, Ichiro Tsuji

    Nihon eiseigaku zasshi. Japanese journal of hygiene 68 (1) 11-21 2013年

    出版者・発行元:1

    DOI: 10.1265/jjh.68.11  

    ISSN:0021-5082 1882-6482

    eISSN:1882-6482

    詳細を見る 詳細を閉じる

    OBJECTIVE: The purpose of this study was to examine the effectiveness of the Functional Improvement Program of the Musculoskeletal System among users of Preventive Care Service under Long-Term Care Insurance. METHODS: A total of 3,073 subjects were analyzed. We used the prediction formula to estimate the predicted value of the Kihon Checklist after one year, and calculated the measured value minus the predicted value. The subjects were divided into two groups according to the measured value minus predicted value tertiles: the lowest and middle tertile (good-to-fair measured value) and the highest tertile (poor measured value). We used a multiple logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of the good-to-fair measured values of the Kihon Checklist after one year, according to the Functional Improvement Program of the Musculoskeletal System. RESULTS: In potentially dependent elderly, the multivariate adjusted ORs (95% CI) of the good-to-fair measured values were 2.4 (1.3-4.4) for those who attended the program eight times or more in a month (vs those who attended it three times or less in a month), 1.3 (1.0-1.8) for those who engaged in strength training using machines (vs those who did not train), and 1.4 (1.0-1.9) for those who engaged in endurance training. CONCLUSIONS: In this study, among potentially dependent elderly, those who attended the program eight times or more in a month and those who engaged in strength training using machines or endurance training showed a significant improvement of their functional capacity.

  254. All-Cause Mortality Among Men Whose Cohabiting Partner Has Been Diagnosed with Cancer 査読有り

    Naoki Nakaya, Kumi Saito-Nakaya, Pernille E. Bidstrup, Susanne O. Dalton, Kirsten Frederiksen, Hanne Wurtzen, Marianne Steding-Jessen, Yosuke Uchitomi, Morten Frisch, Christoffer Johansen

    EPIDEMIOLOGY 24 (1) 96-99 2013年1月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/EDE.0b013e318276cced  

    ISSN:1044-3983

    詳細を見る 詳細を閉じる

    Background: Previous studies suggest that spouses of cancer patients are at increased risk for several chronic diseases. We investigated mortality in relation to cancer morbidity in the stable female partner. Methods: We established a national retrospective cohort study of 1,422,131 men who had lived continuously with the same partner for at least 5 years and used Cox regression analysis to assess the association between experiencing cancer in a cohabiting partner and all-cause mortality. Results: The risk for death was only slightly elevated among men whose partner had cancer than for men whose partner remained free of cancer (hazard ratio = 1.03; 95% confidence interval = 1.01-1.05). Conclusions: Although a cancer diagnosis in a spouse might be associated with considerable distress, our study indicates that the risk for death differs only slightly between men living with a partner with cancer and those living with a partner without cancer. (Epidemiology 2013;24: 96-99)

  255. Effects of personality traits on the manifestations of irritable bowel syndrome. 国際誌 査読有り

    Jun Tayama, Naoki Nakaya, Toyohiro Hamaguchi, Tadaaki Tomiie, Masae Shinozaki, Tatsuo Saigo, Susumu Shirabe, Shin Fukudo

    BioPsychoSocial medicine 6 (1) 20-20 2012年10月30日

    出版者・発行元:1

    DOI: 10.1186/1751-0759-6-20  

    詳細を見る 詳細を閉じる

    OBJECTIVE: Previous studies have reported that patients with irritable bowel syndrome (IBS) show high neuroticism. However, the precise association between the IBS subtypes and the degree of neuroticism in younger populations is largely unknown. We tested our hypothesis that subjects with diarrhea-predominant IBS may have a higher degree of neuroticism than subjects without IBS or those with other subtypes of IBS. We also verified the additional hypothesis that the severity of neuroticism might be correlated with the severity of IBS in younger populations. METHODS: We conducted a cross-sectional survey of 557 university students, ranging in age from 18 to 21 years. Presence/ absence of IBS and determination of the IBS subtype was by the Rome II Modular Questionnaire, while the severity of IBS was determined by the IBS severity index (IBS-SI). The degree of neuroticism was evaluated using the Maudsely Personality Inventory (MPI). The presence/absence of psychological distress was measured with the K6 scale. RESULTS: Neuroticism scores in the subjects with diarrhea-predominant IBS were significantly higher than those in the non-IBS subjects or subjects with constipation-predominant IBS. The neuroticism scores were significantly correlated with the IBS-SI scores in all subjects with IBS. CONCLUSION: These results suggest that neuroticism is involved in the pathophysiology of IBS in young subjects, especially in that of the diarrhea-predominant subtype.

  256. Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells 査読有り

    Hideto Koso, Haruna Takeda, Christopher Chin Kuan Yew, Jerrold M. Ward, Naoki Nariai, Kazuko Ueno, Masao Nagasaki, Sumiko Watanabe, Alistair G. Rust, David J. Adams, Neal G. Copeland, Nancy A. Jenkins

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109 (44) E2998-E3007 2012年10月

    出版者・発行元:NATL ACAD SCIENCES

    DOI: 10.1073/pnas.1215899109  

    ISSN:0027-8424

    詳細を見る 詳細を閉じる

    Neural stem cells (NSCs) are considered to be the cell of origin of glioblastoma multiforme (GBM). However, the genetic alterations that transform NSCs into glioma-initiating cells remain elusive. Using a unique transposon mutagenesis strategy that mutagenizes NSCs in culture, followed by additional rounds of mutagenesis to generate tumors in vivo, we have identified genes and signaling pathways that can transform NSCs into glioma-initiating cells. Mobilization of Sleeping Beauty transposons in NSCs induced the immortalization of astroglial-like cells, which were then able to generate tumors with characteristics of the mesenchymal subtype of GBM on transplantation, consistent with a potential astroglial origin for mesenchymal GBM. Sequence analysis of transposon insertion sites from tumors and immortalized cells identified more than 200 frequently mutated genes, including human GBM-associated genes, such as Met and Nf1, and made it possible to discriminate between genes that function during astroglial immortalization vs. later stages of tumor development. We also functionally validated five GBM candidate genes using a previously undescribed high-throughput method. Finally, we show that even clonally related tumors derived from the same immortalized line have acquired distinct combinations of genetic alterations during tumor development, suggesting that tumor formation in this model system involves competition among genetically variant cells, which is similar to the Darwinian evolutionary processes now thought to generate many human cancers. This mutagenesis strategy is faster and simpler than conventional transposon screens and can potentially be applied to any tissue stem/progenitor cells that can be grown and differentiated in vitro.

  257. PERITRAUMATIC DISTRESS, WATCHING TELEVISION AND POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE 査読有り

    Y. Matsuoka, D. Nishi, N. Nakaya, T. Sone, H. Noguchi, K. Hamazaki, T. Hamazaki, Y. Koido

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE 19 S249-S249 2012年9月

    出版者・発行元:SPRINGER

    DOI: 10.1371/journal.pone.0035248  

    ISSN:1070-5503

    eISSN:1532-7558

  258. Clinical biopsychosocial risk factors for depression in lung cancer patients: a comprehensive analysis using data from the Lung Cancer Database Project 査読有り

    K. Shimizu, N. Nakaya, K. Saito-Nakaya, T. Akechi, Y. Yamada, M. Fujimori, A. Ogawa, D. Fujisawa, K. Goto, M. Iwasaki, S. Tsugane, Y. Uchitomi

    ANNALS OF ONCOLOGY 23 (8) 1973-1979 2012年8月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/annonc/mds061  

    ISSN:0923-7534

    詳細を見る 詳細を閉じる

    Various risk factors for depression in lung cancer patients have been suggested but have been examined separately in studies with relatively small sample sizes. The present study examined the biopsychosocial risk factors of depression in lung cancer patients, focusing on psychological factors in the largest patient sample reported to date. A total of 1334 consecutively recruited lung cancer patients were selected, and data on cancer-related variables, personal characteristics, health behaviors, physical symptoms, and psychological factors were obtained. The participants were divided into groups with or without depression using the Hospital Anxiety and Depression Scale. Among the recruited patients, 165 (12.4 % ) manifested depression. The results of a binary logistic regression analysis were significant (overall R-2, 36.5 % ), and a greater risk for depression was strongly associated with psychological factors, such as personality characteristics (neuroticism) and coping style (low fighting spirit, helplessness/hopelessness, and anxious preoccupation). Although the contributions of cancer-related variables, personal characteristics, health behaviors, and clinical state were relatively low, cancer stage, cancer type, sex, and age correlated significantly with depression. Depression was most strongly linked with personality traits and coping style, and using screening instruments to identify these factors may be useful for preventive interventions.

  259. The predictive power of physical function assessed by questionnaire and physical performance measures for subsequent disability 査読有り

    Masayuki Hoshi, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Kaijun Niu, Kazuki Fujita, Shouzoh Ueki, Hiroshi Haga, Ryoichi Nagatomi, Ichiro Tsuji

    Aging Clinical and Experimental Research 24 (4) 345-353 2012年8月

    DOI: 10.3275/8104  

    ISSN:1594-0667 1720-8319

    eISSN:1720-8319

    詳細を見る 詳細を閉じる

    Background and aims: To compare the predictive power of physical function assessed by questionnaire and physical performance measures for subsequent disability in community-dwelling elderly persons. Methods: Prospective cohort study. Participants were 813 aged 70 years and older, elderly Japanese residing in the community, included in the Tsurugaya Project, who were not disabled at the baseline in 2003. Physical function was assessed by the questionnaire of "Motor Fitness Scale". Physical performance measures consisted of maximum walking velocity, timed up and go test (TUG), leg extension power, and functional reach test. The area under the curve (AUC) of the receiver operating characteristic curve for disability was used to compare screening accuracy between Motor Fitness Scale and physical performance measures. Incident disability, defined as certification for long-term care insurance, was used as the endpoint. Results: We observed 135 cases of incident disability during follow-up. The third or fourth quartile for each measure was associated with a significantly increased risk of disability in comparison with the highest quartile. The AUC was 0.70, 0.72, 0.70, 0.68, 0.69 and 0.74, for Motor Fitness Scale, maximum walking velocity, TUG, leg extension power, functional reach test, and total performance score, respectively. Conclusions: The predictive power of physical function assessed by the Motor Fitness Scale was equivalent to that assessed by physical performance measures. Since Motor Fitness Scale can evaluate physical function safely and simply in comparison with physical performance tests, it would be a practical tool for screening persons at high risk of disability. ©2012, Editrice Kurtis.

  260. [Activities in daily life and changes in care level among users of Preventive Care Service under Long-Term Care Insurance]. 査読有り

    Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Jun Aida, Ichiro Okubo, Satoko Ohara, Shuichi Obuchi, Michiko Sugiyama, Seiji Yasumura, Takao Suzuki, Ichiro Tsuji

    Nihon eiseigaku zasshi. Japanese journal of hygiene 67 (3) 401-7 2012年5月

    出版者・発行元:3

    DOI: 10.1265/jjh.67.401  

    ISSN:0021-5082

    詳細を見る 詳細を閉じる

    OBJECTIVES: The aim of this study was to investigate the association between social roles (engaged in working outside or house work) or hobbies and changes in care level among users of Preventive Care Service under Long-Term Care Insurance. METHODS: A total of 8,734 Preventive Care Service users were analyzed. The assessment was conducted between February 2007 and December 2008. The improvement, maintenance, and aggravation in care level were defined by changes in care level from the beginning to the end. To assess their activities in daily life, the participants were asked, "Which is the major activity in your daily life? Please select one from the following: working outside, house work, hobbies, watching television, others, or none." We used the multiple logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of the maintenance or improvement in care level according to the category of activity. RESULTS: As compared with subjects who answered none, the multivariate adjusted ORs (95% CI) of the maintenance or improvement in care level were 2.0 (1.4-2.9) for those who answered working outside, 1.5 (1.2-1.8) for those who answered house work, and 1.5 (1.2-1.9) for those who answered hobbies. However, those who answered watching television or others did not show a significant association with the maintenance or improvement in care level. CONCLUSIONS: In this study, compared with subjects who answered none, those who answered that they were engaged in working outside, house work, or hobbies were associated with having significantly higher ORs of the maintenance or improvement in care level.

  261. Relationship Between Serum Adiponectin Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: The Tsurugaya Project 査読有り

    Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 67 (5) 530-536 2012年5月

    出版者・発行元:OXFORD UNIV PRESS INC

    DOI: 10.1093/gerona/glr191  

    ISSN:1079-5006

    詳細を見る 詳細を閉じる

    Mortality risk tends to be higher among elderly individuals with higher serum adiponectin levels. The objective of this study was to clarify whether the relationship between adiponectin and a higher risk of disability or death can be explained by physical function, bone mineral density, depression, and malnutrition. We analyzed 505 individuals who underwent comprehensive geriatric assessment and who agreed to provide information on long-term care insurance. The endpoint was the composite outcome of death and incident disability defined as a first certification for any level of care need. Relationships between adiponectin and incident disability or death were estimated using the Cox proportional hazards model. During 6 years of follow-up, 179 incident disabilities or deaths occurred. Among them, 20 and 23 died with and without disability, respectively. The risk of incident disability or death was significantly higher among participants with adiponectin greater than or equal to 22.4 (90%) than 8.0 or less (25%) mg/L (Hazard ratio: 95% confidence interval, 1.92: 1.01-3.64) in the model adjusted for age, sex, and metabolic risk factors. Adjustment for N-terminal pro-B-type natriuretic peptide and nutritional status did not substantially alter this risk estimate, although the association ceased to be statistically significant. Adjustment for physical function did attenuate the relationship, however, which ceased to be apparent upon exclusion of disability or death occurring within 3 years of follow-up. The relationship between adiponectin and the composite outcome of incident disability and death was at least partly explained by reduced physical function and wasting in participants with higher adiponectin levels.

  262. C-reactive protein (CRP) is a predictor of high medical-care expenditures in a community-based elderly population aged 70 years and over: The Tsurugaya project 査読有り

    Kaijun Niu, Atsushi Hozawa, Hui Guo, Kaori Ohmori-Matsuda, Yufei Cui, Satoru Ebihara, Naoki Nakaya, Shinichi Kuriyama, Toru Tsuboya, Masako Kakizaki, Takashi Ohrui, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    ARCHIVES OF GERONTOLOGY AND GERIATRICS 54 (3) E392-E397 2012年5月

    出版者・発行元:ELSEVIER IRELAND LTD

    DOI: 10.1016/j.archger.2012.01.014  

    ISSN:0167-4943

    詳細を見る 詳細を閉じる

    Because CRP is a strong independent predictor of various diseases, it was hypothesized that CRP may be a useful predictor or treatment target for medical-care expenditures. The aim of this study was to investigate the relationship between CRP and medical-care expenditures in a community-dwelling elderly population. This prospective cohort study was conducted including 925 Japanese subjects aged &gt;= 70 years. A high-sensitivity CRP assay was used by applying the nephelometric method. Hospitalizations, outpatient visits, and expenditures were ascertained through computerized linkage with claims lodged between August 2002 and March 2008 with the Miyagi National Health Insurance (NHI) Association. Since medical-care expenditures were not normally distributed, the category of high medical-care expenditures (&gt;75th percentile of medical-care expenditures: inpatient expenditures &gt;$494/month; outpatient expenditure &gt;$522/month; total expenditures &gt;$1103/month) was used to examine the relation of CRP levels with medical-care expenditures. Multiple logistic regression analysis was used to examine the relationship between CRP cutoff points (low concentrations: &lt;1.0 mg/L; intermediate concentrations: 1.0-3.0 mg/L; or high concentrations: &gt;= 3.0 mg/L) and medical-care expenditures during 6 year-follow up period. After adjustment for potential confounding factors, a positive association of CRP with hospitalization, and total expenditures (p for trend = 0.03 and 0.02, respectively) was found. An elevated baseline CRP level is an independent predictor of increases in prospective medical-care expenditures among community-dwelling elderly. Further study is required to clarify whether reducing CRP by intervention is a cost-effective measure. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

  263. Peritraumatic Distress, Watching Television, and Posttraumatic Stress Symptoms among Rescue Workers after the Great East Japan Earthquake 査読有り

    Daisuke Nishi, Yuichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka

    PLOS ONE 7 (4) 2012年4月

    出版者・発行元:PUBLIC LIBRARY SCIENCE

    DOI: 10.1371/journal.pone.0035248  

    ISSN:1932-6203

    詳細を見る 詳細を閉じる

    Background: The Great East Japan Earthquake of March 11, 2001 left around 20,000 dead or missing. Previous studies showed that rescue workers, as well as survivors, of disasters are at high risk for posttraumatic stress disorder (PTSD). This study examined the predictive usefulness of the Peritraumatic Distress Inventory (PDI) among rescue workers of Disaster Medical Assistance Teams (DMATs) deployed during the acute disaster phase of the Great East Japan Earthquake. Methodology/Principal Findings: In this prospective observational study, the DMAT members recruited were assessed 1 month after the earthquake on the PDI and 4 months after the earthquake on the Impact of Event Scale-Revised to determine PTSD symptoms. The predictive value of the PDI at initial assessment for PTSD symptoms at the follow-up assessment was examined by univariate and multiple linear regression analysis. Of the 254 rescue workers who participated in the initial assessment, 173 completed the follow-up assessment. Univariate regression analysis revealed that PDI total score and most individual item scores predicted PTSD symptoms. In particular, high predictive values were seen for peritraumatic emotional distress such as losing control of emotions and being ashamed of emotional reactions. In multiple linear regression analysis, PDI total score was an independent predictor for PTSD symptoms after adjusting for covariates. As for covariates specifically, watching earthquake television news reports for more than 4 hours per day predicted PTSD symptoms. Conclusions/Significance: The PDI predicted PTSD symptoms in rescue workers after the Great East Japan Earthquake. Peritraumatic emotional distress appears to be an important factor to screen for individuals at risk for developing PTSD among medical rescue workers. In addition, watching television for extended period of time might require attention at a time of crisis.

  264. EFFECT OF BASELINE SELF-EFFICACY ON PHYSICAL ACTIVITY AND PSYCHOLOGICAL STRESS AFTER A ONE-WEEK PEDOMETER INTERVENTION 査読有り

    Jun Tayama, Hironori Yamasaki, Mami Tamai, Masaki Hayashida, Susumu Shirabe, Kazuki Nishiura, Toyohiro Hamaguchi, Tadaaki Tomiie, Naoki Nakaya

    PERCEPTUAL AND MOTOR SKILLS 114 (2) 407-418 2012年4月

    出版者・発行元:SAGE PUBLICATIONS INC

    DOI: 10.2466/24.27.PMS.114.2.407-418  

    ISSN:0031-5125

    eISSN:1558-688X

    詳細を見る 詳細を閉じる

    Physical activity and psychological stress were hypothesized to improve more in participants with high self-efficacy than in those with low and medium self-efficacy, after a one-week intervention. 39 female university students participated. The intervention had two steps: a lecture on self-monitoring and goal setting (160 min.) and a one-week pedometer intervention. Analyses were conducted on tertile groups according to self-efficacy at baseline. Pedometer step counts were higher in the high self-efficacy group than in the low self-efficacy group after intervention. Helplessness decreased time dependently after intervention only in the high-self-efficacy group. Because physical activity improved more in the high self-efficacy group after a one-week intervention, one hypothesis was supported.

  265. Stress and survival after cancer: A prospective study of a Finnish population-based cohort 査読有り

    Kumi Saito-Nakaya, Pernille E. Bidstrup, Naoki Nakaya, Kirsten Frederiksen, Susanne O. Dalton, Yosuke Uchitomi, Pia Verkasalo, Markku Koskenvuo, Eero Pukkala, Jaakko Kaprio, Christoffer Johansen

    CANCER EPIDEMIOLOGY 36 (2) 230-235 2012年4月

    出版者・発行元:ELSEVIER SCI LTD

    DOI: 10.1016/j.canep.2011.04.008  

    ISSN:1877-7821

    詳細を見る 詳細を閉じる

    Stress has been suggested to reduce survival after cancer, but the results of previous studies have been contradictory. We investigated the hypothesis in a national cohort of adults in Finland. Of those who completed the Stressful Life Events scale and the Stress of Daily Activities scale, 1470 and 1882, respectively, later had cancer and were included in the analysis, covering 23 years of follow-up between 1982 and 2004. In Cox regression analysis, the multivariate hazard ratio (HR) was 0.99 (95% confidence interval [CI], 0.96-1.01) for total number of life events and the HR for the life change score was 0.99 (95% CI, 0.95-1.03). Further, the HR was 0.92 (95% CI, 0.69-1.22) for severe daily stress. Overall, the results of the current study do not support the hypothesis that stress reduces cancer survival. (C) 2011 Elsevier Ltd. All rights reserved.

  266. Concern over radiation exposure and psychological distress among rescue workers following the Great East Japan Earthquake 査読有り

    Yutaka Matsuoka, Daisuke Nishi, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yuichi Koido

    BMC PUBLIC HEALTH 12 249 2012年3月

    出版者・発行元:BIOMED CENTRAL LTD

    DOI: 10.1186/1471-2458-12-249  

    ISSN:1471-2458

    詳細を見る 詳細を閉じる

    Background: On March 11, 2011, the Great East Japan Earthquake and tsunami that followed caused severe damage along Japan's northeastern coastline and to the Fukushima Daiichi nuclear power plant. To date, there are few reports specifically examining psychological distress in rescue workers in Japan. Moreover, it is unclear to what extent concern over radiation exposure has caused psychological distress to such workers deployed in the disaster area. Methods: One month after the disaster, 424 of 1816 (24%) disaster medical assistance team workers deployed to the disaster area were assessed. Concern over radiation exposure was evaluated by a single self-reported question. General psychological distress was assessed with the Kessler 6 scale (K6), depressive symptoms with the Center for Epidemiologic Studies Depression Scale (CES-D), fear and sense of helplessness with the Peritraumatic Distress Inventory (PDI), and posttraumatic stress symptoms with the Impact of Event Scale-Revised (IES-R). Results: Radiation exposure was a concern for 39 (9.2%) respondents. Concern over radiation exposure was significantly associated with higher scores on the K6, CES-D, PDI, and IES-R. After controlling for age, occupation, disaster operation experience, duration of time spent watching earthquake news, and past history of psychiatric illness, these associations remained significant in men, but did not remain significant in women for the CES-D and PDI scores. Conclusion: The findings suggest that concern over radiation exposure was strongly associated with psychological distress. Reliable, accurate information on radiation exposure might reduce deployment-related distress in disaster rescue workers.

  267. Green tea consumption and the risk of incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 Study 査読有り

    Yasutake Tomata, Masako Kakizaki, Naoki Nakaya, Toru Tsuboya, Toshimasa Sone, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION 95 (3) 732-739 2012年3月

    出版者・発行元:AMER SOC NUTRITION-ASN

    DOI: 10.3945/ajcn.111.023200  

    ISSN:0002-9165

    詳細を見る 詳細を閉じる

    Background: Previous studies have reported that green tea consumption is associated with a lower risk of diseases that cause functional disability, such as stroke, cognitive impairment, and osteoporosis. Although it is expected that green tea consumption would lower the risk of incident functional disability, this has never been investigated directly. Objective: The objective was to determine the association between green tea consumption and incident functional disability in elderly individuals. Design: We conducted a prospective cohort study in 13,988 Japanese individuals aged &gt;= 65 y. Information on daily green tea consumption and other lifestyle factors was collected via questionnaire in 2006. Data on functional disability were retrieved from the public Longterm Care Insurance database, in which subjects were followed up for 3 y. We used Cox proportional hazards regression analysis to investigate the association between green tea consumption and functional disability. Results: The 3-y incidence of functional disability was 9.4% (1316 cases). The multiple-adjusted HR (95% CI) of incident functional disability was 0.90 (0.77, 1.06) among respondents who consumed 1-2 cups green tea/d, 0.75 (0.64, 0.88) for those who consumed 3-4 cups/d, and 0.67 (0.57, 0.79) for those who consumed &gt;= 5 cups/d in comparison with those who consumed &lt;1 cup/d (P-trend &lt; 0.001). Conclusion: Green tea consumption is significantly associated with a lower risk of incident functional disability, even after adjustment for possible confounding factors. Am J Clin Nutr 2012; 95: 732-9.

  268. QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究 がんリハビリテーションプログラムの開発

    岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 豊田瑶子, 中谷直樹, 永田友美, 並木あかね, 長谷川真紀, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

    QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究 平成23年度 総括・分担研究報告書 45-48 2012年

  269. 介護予防サービス利用者における日常生活の過ごし方と要介護認定等の推移との関連 査読有り

    曽根稔雅, 中谷直樹, 遠又靖丈, 相田潤, 大久保一郎, 大原里子, 大渕修一, 杉山みち子, 安村誠司, 鈴木隆雄, 辻一郎

    日本衛生学雑誌 67 (3) 401-407 2012年

  270. Fish Oil for Attenuating Posttraumatic Stress Symptoms among Rescue Workers after the Great East Japan Earthquake: A Randomized Controlled Trial 査読有り

    Daisuke Nishi, Yuichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka

    PSYCHOTHERAPY AND PSYCHOSOMATICS 81 (5) 315-317 2012年

    出版者・発行元:KARGER

    DOI: 10.1159/000336811  

    ISSN:0033-3190

  271. Impact of blunted perception of dyspnea on medical care use and expenditure, and mortality in elderly people 査読有り

    Satoru Ebihara, Kaijun Niu, Takae Ebihara, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori-Matsuda, Naoki Nakaya, Ryoichi Nagatomi, Hiroyuki Arai, Masahiro Kohzuki, Ichiro Tsuji

    FRONTIERS IN PHYSIOLOGY 3 238 2012年

    出版者・発行元:FRONTIERS RESEARCH FOUNDATION

    DOI: 10.3389/fphys.2012.00238  

    ISSN:1664-042X

    詳細を見る 詳細を閉じる

    Dyspnea is an alarming symptom responsible for millions of patient visits each year. Poor perception of dyspnea might be reasonably attributed to an inappropriately low level of fear and inadequate earlier medical treatment for both patients and physicians, resulting in subsequent intensive care. This study was conducted to evaluate medical care use and cost, and mortality according to the perception of dyspnea in community-dwelling elderly people. We analyzed baseline data from a community-based Comprehensive Geriatric Assessment in 2002. The perception of dyspnea in 479 Japanese community-dwelling elderly people with normal lung function was measured in August 2002. The sensation of dyspnea during breathing with a linear inspiratory resistance of 10, 20, and 30 cmH2O/L/s was rated using the Borg scale. According to the perception of dyspnea, we divided the elderly into tertiles and compared all hospitalizations, out-patient visits, costs, and death through computerized linkage with National Health Insurance beneficiaries claims history files between August 2002 and March 2008. In-patient hospitalization days and medical care costs significantly increased with the blunted perception of dyspnea, resulting in an increase in total medical-costs with blunted perception of dyspnea. With low perception group as reference, the hazard ratios of all-cause mortality were 0.65 (95% CI 0.23-1.89) for intermediate perception group and 0.31 (0.10-0.97) for high perception group, indicating the mortality rate also significantly increased with the blunted perception of dyspnea after multivariates adjustment (p = 0.04). The blunted perception of dyspnea is related to hospitalization, large medical costs, and all-cause mortality in community-dwelling elderly people. These findings provide a rational for preventing serious illness with careful monitoring of objective conditions in the elderly.

  272. Attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among disaster medical assistance team members after the Great East Japan Earthquake: The APOP randomized controlled trial 査読有り

    Yutaka Matsuoka, Daisuke Nishi, Naoki Nakaya, Toshimasa Sone, Kei Hamazaki, Tomohito Hamazaki, Yuichi Koido

    BMC PSYCHIATRY 11 132 2011年8月

    出版者・発行元:BIOMED CENTRAL LTD

    DOI: 10.1186/1471-244X-11-132  

    ISSN:1471-244X

    詳細を見る 詳細を閉じる

    Background: On March 11, 2011, a magnitude 9.0 earthquake, the most powerful ever recorded in Japan, and a massive tsunami struck off the coast of the Sanriku region. A Disaster Medical Assistance Team, a mobile medical team with specialized training that is deployed during the acute phase of a disaster, was dispatched to areas with large-scale destruction and multiple injured and sick casualties. Previous studies have reported critical incident stress (i.e. posttraumatic stress disorder symptoms and depressive symptoms) among rescue workers as well as the need for screening and prevention for posttraumatic stress disorder. So far we have shown in an open trial that posttraumatic stress disorder symptoms in critically injured patients can be reduced by taking omega-3 fatty acids intended to stimulate hippocampal neurogenesis. Method/Design: This study is designed to determine the effectiveness of attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among Disaster Medical Assistance Team members after the Great East Japan Earthquake, and is named the APOP randomized controlled trial which is currently ongoing. First, we will provide psycho-education on posttraumatic distress, which is common in responders to the Disaster Medical Assistance Team members deployed to the disaster area. Second, observational research will be conducted to evaluate critical incident stress following the completion of medical activities. Third, team members who provide consent to participate in the intervention research will be randomly divided into a group given an omega-3 fatty acid supplement and a group not given the supplements. Outcome will be evaluated at 12 weeks after the supplements are shipped to the team members. Discussion: Measures that address critical incident stress in disaster responders are important, but there is no substantial evidence that links such measures with prevention of posttraumatic stress disorder. Thus, any confirmation through this study that the intake of omega-3 fatty acid supplements serves as a simple preventative measure for critical incident stress will be of great significance. Trial registration: UMIN Clinical Trials Registry, UMIN000005367

  273. Impact of physical activity and performance on medical care costs among the Japanese elderly 査読有り

    Guang Yang, Kaijun Niu, Kazuki Fujita, Atsushi Hozawa, Kaori Ohmori-Matsuda, Shinichi Kuriyama, Naoki Nakaya, Satoru Ebihara, Tatsuma Okazaki, Hiu Guo, Chihaya Miura, Hideko Takahashi, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    GERIATRICS & GERONTOLOGY INTERNATIONAL 11 (2) 157-165 2011年4月

    出版者・発行元:WILEY-BLACKWELL

    DOI: 10.1111/j.1447-0594.2010.00651.x  

    ISSN:1444-1586

    詳細を見る 詳細を閉じる

    Aim: Physical activity (PA) is known to be inversely associated with medical care costs. The amount of PA is strongly associated with the level of physical performance among the elderly population. Therefore, it is possible that known relation between PA and medical care merely shows the relation between physical performance and medical care. To know whether PA itself relates to medical care, considering physical performance is necessary. The aim of this study was to ascertain the impact of PA on medical care expenditure by considering the physical performance in an elderly community-dwelling population. Methods: We investigated 483 subjects who did not have any history of diseases relating to limited PA and who completed both a self-administered questionnaire including questions on PA and underwent a physical performance measurement. We ascertained the total medical care costs through a computerized linkage with claims lodged between August 2002 and March 2008 with the Miyagi National Health Insurance Association. Results: The physical performance was positively associated with their level of PA. After multivariate adjustment for covariables including the levels of physical performance, the per capita medical care costs were found to be $US 827.3 (598.0-1056.7) (mean, 95% confidence interval), $US 711.1 (476.4-945.8) and $US 702.0 (461.6-942.4) (P for linear trend = 0.02) per month for those who had the lowest, average and the highest level of PA, respectively. Conclusion: This prospective study indicates that a higher level of PA is associated with lower medical care costs among the Japanese elderly irrespective of physical performance. Geriatr Gerontol Int 2011; 11: 157-165.

  274. Treatment Response to Psychiatric Intervention and Predictors of Response Among Cancer Patients with Adjustment Disorders 査読有り

    Ken Shimizu, Nobuya Akizuki, Naoki Nakaya, Maiko Fujimori, Daisuke Fujisawa, Asao Ogawa, Yosuke Uchitomi

    JOURNAL OF PAIN AND SYMPTOM MANAGEMENT 41 (4) 684-691 2011年4月

    出版者・発行元:ELSEVIER SCIENCE INC

    DOI: 10.1016/j.jpainsymman.2010.07.011  

    ISSN:0885-3924

    詳細を見る 詳細を閉じる

    Context. Although adjustment disorders (ADs) are common among patients with cancer and such patients are frequently referred to consultation-liaison psychiatrists, little is known about the clinical courses of these patients.Objectives. The present study investigated treatment response to psychiatric intervention and predictors of response in a relatively large sampling of cancer patients with ADs.Methods. We created a database of all referral cases with ADs that included data on the patients' demographic and medical factors and physician-rated Clinical Global Impression (CGI) scale to assess treatment response and clinical course. A CGI-Improvement scale score of better than "much improved" was regarded as indicating a response to treatment; the number of patients who responded to treatment during a four-week follow-up period was assessed. Also, predictors of treatment response were explored by examining demographic and medical factors using a multivariate analysis.Results. Among the 238 eligible patients, 136 (57.1%) responded to psychiatric treatment; most of these responders improved to a subthreshold level of illness. On the other hand, 56 patients (23.5%) did not respond to psychiatric treatment, seven patients (2.9%) developed major depressive disorders, and 39 patients (16.4%) discontinued treatment before achieving a response. Among the predictive factors that were explored, suffering from pain significantly predicted a good treatment response, whereas a worse performance status predicted a poor treatment response.Conclusion. Cancer patients with ADs can respond to psychiatric treatment, but a few cases develop major depressive disorders. Several predictors of treatment response were identified. J Pain Symptom Manage 2011; 41: 684-691. (c) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

  275. デンマークにおける保健医療関連データベースに関する調査研究 査読有り

    中谷 直樹, 中谷 久美, 中村 好一, 辻 一郎

    公衆衛生 75 (2) 160-163 2011年2月

    出版者・発行元:(株)医学書院

    DOI: 10.11477/mf.1401102038  

    ISSN:0368-5187

    eISSN:1882-1170

    詳細を見る 詳細を閉じる

    デンマーク政府の所管のもとで継続・実施されている保健医療データベースの概要および研究利用について調査した。医学文献データベース(PubMed)による検索を実施した。疫学専門家2名がPubMedを用い、現在までデンマークで継続・実施されているデータベースを抽出した。245文献が抽出され、そのうち129文献で、抄録中に保健医療関連データベース名が明記されていた。この129文献には、56種のデータベースが含まれていた。抽出された保健医療関連データベースのうち、デンマーク政府が所管しており、多くの文献で引用されていた3つのデータベースについて詳細を検討した。デンマークがん登録データベース、デンマーク死因登録データベース、デンマーク患者登録データベースであった。これら全てのデータベースは現在も維持・継続されており、研究利用が行われている。

  276. QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究 がんリハビリテーションプログラムの開発

    岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 豊田瑶子, 中谷直樹, 永田友美, 並木あかね, 長谷川真紀, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

    QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究 平成22年度 総括・分担研究報告書 34-37 2011年

  277. Randomized controlled trial for an effect of catechin-enriched green tea consumption on adiponectin and cardiovascular disease risk factors 査読有り

    Toshimasa Sone, Shinichi Kuriyama, Naoki Nakaya, Atsushi Hozawa, Taichi Shimazu, Kozue Nomura, Shouzo Rikimaru, Ichiro Tsuji

    FOOD & NUTRITION RESEARCH 55 2011年

    出版者・発行元:TAYLOR & FRANCIS LTD

    DOI: 10.3402/fnr.v55i0.8326  

    ISSN:1654-6628

    eISSN:1654-661X

    詳細を見る 詳細を閉じる

    Background: Previous observational studies have indicated that green tea (GT) consumption is associated with reduced mortality from cerebral infarction but not with mortality from cerebral hemorrhage. Therefore, we hypothesized that GT exerts a direct antiatherosclerotic effect without any effect on hypertension. To investigate this hypothesis, we focused on adiponectin that seems to be among the several key players in atherosclerosis. Objective: The objective of this randomized controlled trial (RCT) was to assess whether the consumption of catechin-enriched GT affects serum adiponectin levels and cardiovascular disease (CVD) risk factors among apparently healthy subjects. Design: A total of 51 individuals participated in the study. Eligible participants were randomly assigned into GT consumption groups with either high catechin (400 mg/day) or low catechin (100 mg/day). The study participants were asked to stop GT consumption for 2 weeks (washout period), following which they were to start drinking the provided GT beverages everyday for 9 weeks. The outcome measures were changes in the adiponectin levels and CVD risk factors (body weight, body mass index, waist circumference, blood pressure, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, as well as aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, and high-sensitive C-reactive protein). Results: After intervention for 9 weeks, we found no significant difference between the high- and low catechin group with respect to changes in the serum adiponectin level: 0.35 mu g/ml (95% confidence interval (CI): -1.03, 1.74). Also, no significant difference was observed between the high- and low catechin groups with respect to changes in any of the measured CVD risk factors. Conclusion: This RCT showed no significant difference between the high-and low catechin groups with respect to changes in the serum adiponectin level and any CVD risk factors.

  278. Increased Risk of Severe Depression in Male Partners of Women With Breast Cancer 査読有り

    Naoki Nakaya, Kumi Saito-Nakaya, Pernille Envold Bidstrup, Susanne Oksbjerg Dalton, Kirsten Frederiksen, Marianne Steding-Jessen, Yosuke Uchitomi, Christoffer Johansen

    CANCER 116 (23) 5527-5534 2010年12月

    出版者・発行元:WILEY-BLACKWELL

    DOI: 10.1002/cncr.25534  

    ISSN:0008-543X

    詳細を見る 詳細を閉じる

    BACKGROUND: A few small studies published to date have suggested that major psychosocial problems develop in the partners of cancer patients; however, to the authors' knowledge, no studies to date have addressed their risk for severe depression. In a retrospective cohort study, the risk for hospitalization with an affective disorder of the male partners of women with breast cancer was investigated, using unbiased, nationwide, population-based information. METHODS: Followed were 1,162,596 men born between 1925 and 1973 who were aged &gt;= 30 years at study entry, resided in Denmark between 1994 and 2006, had no history of hospitalization for an affective disorder, and had lived continuously with the same partner for at least 5 years. A Cox regression analysis included detailed clinical information regarding the diagnosis and treatment of breast cancer and on annually updated socioeconomic and health-related indicators obtained from national administrative and disease registers. RESULTS: During the 13 years of follow-up, breast cancer was diagnosed in the partners of 20,538 men. On multivariable analysis, men whose partner was diagnosed with breast cancer were found to be at an increased risk of being hospitalized with an affective disorder (hazards ratio, 1.39; 95%confidence interval, 1.20-1.61), with a dose-response pattern for the severity of breast cancer. Furthermore, men whose partner died after breast cancer had a significant, 3.6-fold increase in risk for an affective disorder when compared with men whose partner survived breast cancer. CONCLUSIONS: The results of the current study supported the hypothesis that men whose partner had breast cancer were at an increased risk for hospitalization with an affective disorder. Cancer 2010;116:5527-34. (C) 2070 American Cancer Society

  279. RELATIONSHIPS BETWEEN N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE AND INCIDENT DISABILITY AND MORTALITY IN OLDER COMMUNITY-DWELLING ADULTS: THE TSURUGAYA STUDY 査読有り

    Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 58 (12) 2439-2441 2010年12月

    出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC

    DOI: 10.1111/j.1532-5415.2010.03190.x  

    ISSN:0002-8614

  280. Impact of Nocturia on Bone Fracture and Mortality in Older Individuals: A Japanese Longitudinal Cohort Study 査読有り

    Haruo Nakagawa, Kaijun Niu, Atsushi Hozawa, Yoshihiro Ikeda, Yasuhiro Kaiho, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Satoru Ebihara, Ryoichi Nagatomi, Ichiro Tsuji, Yoichi Arai

    JOURNAL OF UROLOGY 184 (4) 1413-1418 2010年10月

    出版者・発行元:ELSEVIER SCIENCE INC

    DOI: 10.1016/j.juro.2010.05.093  

    ISSN:0022-5347

    詳細を見る 詳細を閉じる

    Purpose: We evaluated the association of nocturia with fracture and death in a large, community based sample of Japanese individuals 70 years old or older. Materials and Methods: The baseline in this population based study was determined in 2003 by an extensive health interview with each participant. In this study we followed 784 individuals with a mean +/- SD age of 76.0 +/- 4.6 years (range 70 to 97). Information on mortality and fracture during the study period was provided by the National Health Insurance system and details on fractures were collected from medical records. We compared the risk of bone fracture and death with or without nocturia in a multivariate Cox proportional hazard model. Results: Nocturia (2 or greater voids per night) was present in 359 of the 784 participants (45.7%). Fracture was observed in 41 cases, including 32 fall related cases. For all fractures and fall related fractures with nocturia the HR was 2.01 (95% CI 1.04-3.87) and 2.20 (95% CI 1.04-4.68, each p = 0.04). Death occurred in 53 cases. The mortality rate in individuals with nocturia was significantly higher than in those without nocturia. For mortality in patients with nocturia the age-gender adjusted HR was 1.91 (95% CI 1.07-3.43, p = 0.03). Even when further adjusted for diabetes, smoking status, history of coronary disease, renal disease and stroke, tranquilizers, hypnotics and diuretics, the positive relationship was unchanged (HR 1.98, 95% CI 1.09-3.59, p = 0.03). Conclusions: During a 5-year observation period elderly individuals with nocturia were at greater risk for fracture and death than those without nocturia.

  281. Effect of Autogenic Training on General Improvement in Patients with Irritable Bowel Syndrome: A Randomized Controlled Trial 査読有り

    Masae Shinozaki, Motoyori Kanazawa, Michiko Kano, Yuka Endo, Naoki Nakaya, Michio Hongo, Shin Fukudo

    APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK 35 (3) 189-198 2010年9月

    出版者・発行元:SPRINGER/PLENUM PUBLISHERS

    DOI: 10.1007/s10484-009-9125-y  

    ISSN:1090-0586

    詳細を見る 詳細を閉じる

    Autogenic training (AT) is a useful and comprehensive relaxation technique. However, no studies have investigated the effects of AT on irritable bowel syndrome (IBS). In this study we tested the hypothesis that AT improves symptoms of IBS. Twenty-one patients with IBS were randomly assigned to AT (n = 11, 5 male, 6 female) or control therapy (n = 10, 5 male, 5 female). AT patients were trained intensively, while the control therapy consisted of discussions about patients&apos; meal habits and life styles. All patients answered a question related to adequate relief (AR) of IBS symptoms and four questionnaires: Self-induced IBS Questionnaire (SIBSQ), Self-reported Depression Scale (SDS), State-Trait Anxiety Inventory (STAI), and Medical Outcome Short Form 36 Health Survey (SF-36). The proportion of AR in the last AT session in the AT group (9/11, 81.8%) was significantly higher than that in the controls (3/10, 30.0%, Chi-square test, p = 0.048). Two subscales of the SF-36, i.e., social functioning and bodily pain, were significantly improved in the AT group (p &lt; 0.05) as compared to the control group. Role emotional (p = 0.051) and general health (p = 0.068) showed a tendency for improvement in the AT group. AT may be useful in the treatment of IBS by enhancing self-control.

  282. Personality Traits and Cancer Risk and Survival Based on Finnish and Swedish Registry Data 査読有り

    Naoki Nakaya, Pernille E. Bidstrup, Kumi Saito-Nakaya, Kirsten Frederiksen, Markku Koskenvuo, Eero Pukkala, Jaakko Kaprio, Birgitta Floderus, Yosuke Uchitomi, Christoffer Johansen

    AMERICAN JOURNAL OF EPIDEMIOLOGY 172 (4) 377-385 2010年8月

    出版者・発行元:OXFORD UNIV PRESS INC

    DOI: 10.1093/aje/kwq046  

    ISSN:0002-9262

    詳細を見る 詳細を閉じる

    Personality traits have been studied extensively as risk and prognostic factors for cancer; however, the association remains unclear. This prospective, population-based cohort study comprised 59,548 Swedish (1974-1999) and Finnish (1976-2004) participants who completed a questionnaire eliciting information for the Eysenck Personality Inventory and on health behavior at baseline. To analyze the association of personality traits extraversion and neuroticism with risk of cancer, the authors identified 4,631 cancer cases for a maximum 30 years of follow-up. To assess the association with cancer survival among the Finnish participants, they identified 2,733 cancer cases and, later, 1,548 deaths for a maximum 29 years of follow-up. Hazard ratios were estimated by treating the personality scales as continuous variables and are presented per one increase in score on each scale. In multivariate analyses, extraversion and neuroticism were not significantly associated with risk of cancers at all sites (extraversion: hazard ratio = 0.99, 95% confidence interval: 0.98, 1.01; neuroticism: hazard ratio = 1.00, 95% confidence interval: 0.99, 1.02). Results showed no significant association between these traits and the hazard ratio for death after cancers at all sites, and they do not support the hypothesis that extraversion and neuroticism are direct risk factors for cancer or survival after cancer.

  283. [Depression and the risk of long-term care insurance certification: the Tsurugaya project]. 査読有り

    Ohmori-Matsuda K, Hozawa A, Sone T, Koizumi-Masamune Y, Nakaya N, Kuriyama S, Suzuki S, Awata S, Tsuji I

    [Nihon koshu eisei zasshi] Japanese journal of public health 57 (7) 538-549 2010年7月

    出版者・発行元:7

    DOI: 10.11236/jph.57.7_538  

    ISSN:0546-1766

    詳細を見る 詳細を閉じる

    <b>目的</b> 地域高齢者におけるうつ状態の程度とその後の介護保険の要支援•要介護認定リスクとの関連をコホート研究により検討すること,さらにその関連に男女差があるかを検討すること。<br/><b>方法</b> 仙台市宮城野区鶴ヶ谷地区の70歳以上住民全員(2,925人)に対し,高齢者総合機能評価「寝たきり予防健診」を平成15年に行った。受診者(958人)のうち,研究利用への同意が得られ介護保険認定非該当であった者841人を解析対象とした。うつ状態は30項目の Geriatric Depression Scale (GDS)で評価した。抗うつ薬内服または GDS14点以上(中等度~重度うつ群),10-13点(軽度うつ群),9 点以下(健常)の 3 群に分類し要支援•要介護認定リスクを Cox 比例ハザードモデルにより算出した。<br/><b>結果</b> 4 年間の追跡調査で151人が要支援•要介護認定を受け,46人が死亡した。うつ状態は特に男性において要支援•要介護認定リスクと関連していた。男性では,健常群と比較した要支援•要介護認定の年齢補正ハザード比は,軽度うつ群で1.77(95%信頼区間(CI):0.91-3.48),中等度~重度うつ群で2.26(1.11-4.64)と,うつ状態の程度とともに有意に増加した(傾向性の <i>P</i> 値=0.023)。これは,疾患既往歴,ソーシャルサポートの有無,喫煙,認知機能などの影響を補正しても変わらなかった(多変量補正ハザード比;軽度うつ群:1.31(95%CI:0.65-2.65),中等度~重度うつ群:2.19(1.06-4.54),傾向性の <i>P</i>=0.034)。一方,女性では,うつ状態と要支援•要介護認定リスクとの間に有意な関連は認められなかった。また,うつ状態と死亡リスクには男女ともに有意な関連は認められなかった。<br/><b>結論</b> うつ状態と要支援•要介護認定リスクは,男性でのみ有意な関連が認められた。それは,ベースラインの既往歴,心身機能,社会的要因,生活習慣を補正してもなお認められた。うつ状態の要支援•要介護認定発生への影響は男女で異なる可能性が示唆された。地域高齢者のうつ対策が,生活の質の向上のみでなく,特に男性高齢者において,介護予防に重要であることが示された。

  284. Gastric Hyposecretion in Esophageal Squamous-Cell Carcinomas 査読有り

    K. Iijima, T. Koike, Y. Abe, H. Yamagishi, N. Ara, K. Asanuma, K. Uno, A. Imatani, N. Nakaya, S. Ohara, T. Shimosegawa

    DIGESTIVE DISEASES AND SCIENCES 55 (5) 1349-1355 2010年5月

    出版者・発行元:SPRINGER

    DOI: 10.1007/s10620-009-0853-x  

    ISSN:0163-2116

    詳細を見る 詳細を閉じる

    Recently, gastric fundic atrophy is reported to be an independent risk factor for esophageal squamous-cell carcinoma (ESCC). The aim of this study is to investigate the acid secretory level in ESCC in a case-control study. From April 2004 to March 2008, 100 consecutive subjects with early ESCC and 100 age- and sex-matched asymptomatic controls were prospectively enrolled. Gastrin-stimulated acid output was assessed by endoscopic gastrin test. Conditional regression analyses were used to adjust for other potential confounders. Multivariate analyses revealed a strong association between profound hypochlorhydria and ESCC with odds ratio (95% confidence interval): 6.0 (1.9-18.4). The association remained significant after adjusting for the effect of gastric atrophy as a covariate. The association became stronger as the ESCC developed more distal site of the esophagus. This study indicates that profound hypochlorhydria is a strong independent risk factor for ESCC even after adjusting for the influence of gastric atrophy.

  285. Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women 査読有り

    Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

    JOURNAL OF NUTRITION 140 (5) 1007-1013 2010年5月

    出版者・発行元:AMER SOC NUTRITIONAL SCIENCE

    DOI: 10.3945/jn.109.109314  

    ISSN:0022-3166

    詳細を見る 詳細を閉じる

    Coffee contains various compounds that have recently been reported to exert beneficial health effects. However, the conclusion of its relation with mortality has not yet been reached. In this study, we aimed to investigate the associations between coffee consumption and all-cause and cause-specific mortality in Japan. We included 37,742 participants (18,287 men and 19,455 women) aged 40-64 y without a history of cancer, myocardial infarction, or stroke at baseline in our analysis, based on the Miyagi Cohort Study initiated in 1990. The outcomes were mortality due to all causes, cardiovascular disease (CVD), and cancer. During the 10.3 y of follow-up, 2454 participants died, including 426 due to CVD and 724 due to cancer. In women, the multivariate hazard ratios (HR) (95% CI) for all-cause mortality in participants who drank coffee never, occasionally, 1-2 cups (150-300 mL)/d, and &gt;= 3 cups/d were 1.00, 0.88 (0.73-1.06), 0.82 (0.66-1.02), and 0.75(0.53-1.05), respectively (P-trend = 0.04). For CVD mortality in women, the multivariate HR (95% CI) were 1.00, 0.56 (0.36-0.86), 0.48 (0.29-0.80), and 0.45 (0.20-1.03), respectively (P-trend = 0.006). Of the specific CVD diseases, there was a strong inverse association between coffee consumption and mortality due to coronary heart disease (CHD) in women (P-trend = 0.02) but not in men. Death due to cancer was not associated with coffee consumption in either men or women, except for colorectal cancer in women. Our results suggest that coffee may have favorable effects on morality due to all causes and to CVD, especially CHD, in women. J. Nutr. 140: 1007-1013, 2010.

  286. The Ohsaki Cohort 2006 Study: Design of Study and Profile of Participants at Baseline 査読有り

    Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Yasutake Tomata, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY 20 (3) 253-258 2010年5月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.JE20090093  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    Background: Large-scale cohort studies conducted in Japan do not always include psychosocial factors as exposures. In addition, such studies sometimes fail to satisfactorily evaluate disability status as an outcome. Methods: This prospective cohort study comprised 49 603 (22 438 men and 27 165 women) community-dwelling adults aged 40 years or older who were included in the Residential Registry for Ohsaki City, Miyagi Prefecture, in northeastern Japan. The baseline survey, which included psychosocial factors, was conducted in December 2006. Follow-up of death, immigration, cause of death, cancer incidence, and long-term care insurance certification was started on 1 January 2007. Results: The response rate vas 64.2%. In general, lifestyle-related conditions in the study population were similar to those of the general Japanese population; however, the proportion of male current smokers was higher in the cohort. The association between age and the proportion of those reporting psychological distress showed a clear U-shaped curve, with a nadir at age 60 to 69 years in both men and women, although more women were affected by such distress than men. The proportion of those who reported a lack of social support was highest among those aged 40 to 49 years. Most men and women surveyed did not participate in community activities. Among participants aged 65 years or older, 10.9% of participants were certified beneficiaries of the long-term care insurance system at baseline. Conclusions: The Ohsaki Cohort 2006 Study is a novel population-based prospective cohort study that focuses on psychosocial factors and long-term care insurance certification.

  287. Association between green tea consumption and tooth loss: Cross-sectional results from the Ohsaki Cohort 2006 Study 査読有り

    Yasushi Koyama, Shinichi Kuriyama, Jun Aida, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Ichiro Tsuji

    PREVENTIVE MEDICINE 50 (4) 173-179 2010年4月

    出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE

    DOI: 10.1016/j.ypmed.2010.01.010  

    ISSN:0091-7435

    詳細を見る 詳細を閉じる

    Objective. To examine the association between green tea consumption and tooth loss. Methods. We analyzed cross-sectional data from the Ohsaki Cohort 2006 Study. Usable self-administered questionnaires about green tea consumption and tooth loss were returned from 25,078 persons (12,019 men and 13,059 women) aged 40 to 64 years in Japan. Multivariate logistic regression analysis was used to calculate odds ratios (ORs) for tooth loss using 3 cut-off points of 10, 20, and 25 teeth relative to each category of green tea consumption. Results. Consumption of &gt;= 1 cup/day of green tea was significantly associated with decreased odds for tooth loss, and the association appeared to fit a threshold model. In men. the multivariate-adjusted ORs for tooth loss with a cut-off point of &lt;20 teeth associated with different frequencies of green tea consumption were 1.00 (reference) for &lt;1 cup/day, 0.82 (95% CI, 0.74-0.91) for 1-2 cups/day, 0.82 (95% CI, 0.73-0.92) for 3-4 cups/day, and 0.77 (95% CI, 0.66-0.89) for &gt;= 5 cups/day. The corresponding data for women and the results for cut-off points of 10 and 25 teeth were essentially the same. Conclusions. The present findings indicate an association of green tea consumption with decreased odds for tooth loss. (C) 2010 Elsevier Inc. All rights reserved.

  288. 【がん患者のサバイバーシップ】社会的問題(退職・未就労リスクおよび離婚リスク) 査読有り

    中谷 直樹, 中谷 久美

    腫瘍内科 5 (2) 122-130 2010年2月

    出版者・発行元:(有)科学評論社

    ISSN:1881-6568

  289. QOLの向上のための各種患者支援プログラムの開発に関する研究 がんリハビリテーションプログラムの開発

    岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 緒方政美, 小野久美子, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 曽根稔雅, 田辺瑶子, 中谷直樹, 永田友美, 並木あかね, 濱口豊太, 吉原広和, 余宮きのみ

    QOLの向上のための各種患者支援プログラムの開発に関する研究 平成21年度 総括・分担研究報告書 32-35 2010年

  290. Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study 査読有り

    Yasutake Monma, Kaijun Niu, Koh Iwasaki, Naoki Tomita, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Shin Takayama, Takashi Seki, Takashi Takeda, Nobuo Yaegashi, Satoru Ebihara, Hiroyuki Arai, Ryoichi Nagatomi, Ichiro Tsuji

    BMC GERIATRICS 10 31 2010年

    出版者・発行元:BIOMED CENTRAL LTD

    DOI: 10.1186/1471-2318-10-31  

    ISSN:1471-2318

    詳細を見る 詳細を閉じる

    Background: Diet is considered an important factor for bone health, but is composed of a wide variety of foods containing complex combinations of nutrients. Therefore we investigated the relationship between dietary patterns and fall-related fractures in the elderly. Methods: We designed a population-based prospective survey of 1178 elderly people in Japan in 2002. Dietary intake was assessed with a 75-item food frequency questionnaire (FFQ), from which dietary patterns were created by factor analysis from 27 food groups. The frequency of fall-related fracture was investigated based on insurance claim records from 2002 until 2006. The relationship between the incidence of fall-related fracture and modifiable factors, including dietary patterns, were examined. The Cox proportional hazards regression model was used to examine the relationships between dietary patterns and incidence of fall-related fracture with adjustment for age, gender, Body Mass Index (BMI) and energy intake. Results: Among 877 participants who agreed to a 4 year follow-up, 28 suffered from a fall-related fracture. Three dietary patterns were identified: mainly vegetable, mainly meat and mainly traditional Japanese. The moderately confirmed (see statistical methods) groups with a Meat pattern showed a reduced risk of fall-related fracture (Hazard ratio = 0.36, 95% CI = 0.13 - 0.94) after adjustment for age, gender, BMI and energy intake. The Vegetable pattern showed a significant risk increase (Hazard ratio = 2.67, 95% CI = 1.03 - 6.90) after adjustment for age, gender and BMI. The Traditional Japanese pattern had no relationship to the risk of fall-related fracture. Conclusions: The results of this study have the potential to reduce fall-related fracture risk in elderly Japanese. The results should be interpreted in light of the overall low meat intake of the Japanese population.

  291. Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project 査読有り

    Akemi Nitta, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Satoru Ebihara, Masataka Ichiki, Hiroyuki Arai, Ichiro Tsuji

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 17 (12) 1290-1296 2010年

    出版者・発行元:JAPAN ATHEROSCLEROSIS SOC

    DOI: 10.5551/jat.5389  

    ISSN:1340-3478

    eISSN:1880-3873

    詳細を見る 詳細を閉じる

    Aim: The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions. Methods: We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model. Results: After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95% CI: 1.06 to 3.26). Although the risk was attenuated (HR = 1.63, 95% CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD. Conclusion: PAD is an important predictor of disability even if the level of baseline physical function is high.

  292. Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study 査読有り

    Akane Ui, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

    CANCER CAUSES & CONTROL 20 (10) 1939-1945 2009年12月

    出版者・発行元:SPRINGER

    DOI: 10.1007/s10552-009-9388-x  

    ISSN:0957-5243

    詳細を見る 詳細を閉じる

    To investigate the association between green tea consumption and liver cancer incidence. We prospectively followed 41,761 Japanese adults aged 40-79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean. Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for &lt; 1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for a parts per thousand yen5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90) (p for trend = 0.04). Green tea consumption is associated with a reduced risk of liver cancer incidence.

  293. Green tea consumption is associated with depressive symptoms in the elderly 査読有り

    Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Satoru Ebihara, Hui Guo, Naoki Nakaya, Kaori Ohmori-Matsuda, Hideko Takahashi, Yayoi Masamune, Masanori Asada, Satoshi Sasaki, Hiroyuki Arai, Shuichi Awata, Ryoichi Nagatomi, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION 90 (6) 1615-1622 2009年12月

    出版者・発行元:AMER SOC CLINICAL NUTRITION

    DOI: 10.3945/ajcn.2009.28216  

    ISSN:0002-9165

    詳細を見る 詳細を閉じる

    Background: Green tea is reported to have various beneficial effects (eg, anti-stress response and antiinflammatory effects) on human health. Although these functions might be associated with the development and progression of depressive symptoms, no studies have investigated the relation between green tea consumption and depressive symptoms in a community-dwelling population. Objective: The aim of this study was to investigate the relations between green tea consumption and depressive symptoms in elderly Japanese subjects who widely consumed green tea. Design: We conducted a cross-sectional study in 1058 community-dwelling elderly Japanese individuals aged &gt;= 70 y. Green tea consumption was assessed by using a self-administered questionnaire, and depressive symptoms were evaluated by using the 30-item Geriatric Depression Scale with 2 cutoffs: 11 (mild and severe depressive symptoms) and 14 (severe depressive symptoms). If a participant was consuming antidepressants, he or she was considered to have depressive symptoms. Results: The prevalence of mild and severe and severe depressive symptoms was 34.1% and 20.2%, respectively. After adjustment for confounding factors, the odds ratios (95% CI) for mild and severe depressive symptoms when higher green tea consumption was compared with green tea consumption of &lt;= 1 cup/d were as follows: 2-3 cups green tea/d (0.96; 95% CI: 0.66, 1.42) and &gt;= 4 cups green tea/d (0.56; 95% CI: 0.39, 0.81) (P for trend: 0.001). Similar relations were also observed in the case of severe depressive symptoms. Conclusion: A more frequent consumption of green tea was associated with a lower prevalence of depressive symptoms in the community-dwelling older population. Am J Clin Nutr 2009;90:1615-22.

  294. Factors Associated With Psychological Distress in a Community-Dwelling Japanese Population: The Ohsaki Cohort 2006 Study 査読有り

    Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY 19 (6) 294-302 2009年11月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.JE20080076  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    Background: In Asia, there has been no population-based epidemiological study using the K6, a 6-item instrument that assesses nonspecific psychological distress. Methods: Using cross-sectional data from 2006, we studied 43 716 (20 168 men and 23 548 women) community-dwelling people aged 40 years or older living in Japan. We examined the association between psychological distress and demographic, medical, lifestyle, and social factors by using the K6, with psychological distress defined as 13 or more points out of a total of 24 points. Results: The following variables were significantly associated with psychological distress among the population: female sex, young and old age, a history of serious disease (hypertension, diabetes mellitus, stroke, myocardial infarction, or cancer), current smoking, former alcohol drinking, low body mass index, shorter daily walking time, lack of social support (4 of 5 components), and lack of participation in community activities (4 of 5 components). Among men aged 40 to 64 years, only "lack of social support for consultation when in trouble" and a history of diabetes mellitus remained significant on multivariate analysis. Among men aged 65 years or older, age was not significantly associated with psychological distress, and the significant association with current smoking disappeared on multivariate analysis. Among women aged 40 to 64 years, a history of stroke was not associated with psychological distress. Among women aged 65 years or older, the significant association with current smoking disappeared on multivariate analysis. Conclusions: A number of factors were significantly associated with psychological distress, as assessed by the K6. These factors differed between men and women, and also between middle-aged and elderly people.

  295. Mental Vulnerability and Survival After Cancer 査読有り

    Naoki Nakaya, Pernille E. Bidstrup, Lene F. Eplov, Kumi Saito-Nakaya, Shinichi Kuriyama, Ichiro Tsuji, Yosuke Uchitomi, Christoffer Johansen

    EPIDEMIOLOGY 20 (6) 916-920 2009年11月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/EDE.0b013e3181b5f3b0  

    ISSN:1044-3983

    詳細を見る 詳細を閉じる

    Background: It has been hypothesized that personality traits affect survival after cancer, but studies have produced inconsistent results. This study examined the association between mental vulnerability and survival after cancer in Denmark in a prospective cohort study. Methods: Between 1976 and 2001, 12733 residents of Copenhagen completed a questionnaire eliciting information on a 12-item mental vulnerability scale, as well as various personal data. Follow-up in the Danish Cancer Registry until 2003 identified 884 incident cases of primary cancer, and follow-up for death from the date of cancer diagnosis until 2003 identified 382 deaths. Mental vulnerability scores were divided into 4 approximately equal-sized groups. Cox proportional hazards regression models were used to estimate the hazard ratio (HR) of all-cause mortality. Results: Multivariate HR for all-cause mortality for persons in the highest category of mental vulnerability compared with those at the lowest was 1.1 (95% confidence interval = 0.9-1.5). Conclusion: We found no support for the hypothesis that mental vulnerability is associated with survival after cancer diagnosis.

  296. Green tea consumption is associated with lower psychological distress in a general population: the Ohsaki Cohort 2006 Study 査読有り

    Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Masako Kakizaki, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Akemi Nitta, Yasutake Tomata, Kaijun Niu, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION 90 (5) 1390-1396 2009年11月

    出版者・発行元:AMER SOC CLINICAL NUTRITION

    DOI: 10.3945/ajcn.2009.28214  

    ISSN:0002-9165

    詳細を見る 詳細を閉じる

    Background: Although green tea or its constituents might reduce psychological stress, the relation between green tea consumption and psychological distress has not been investigated in a large-scale study. Objective: Our aim was to clarify whether green tea consumption is associated with lower psychological distress. Design: We analyzed cross-sectional data for 42,093 Japanese individuals aged &gt;= 40 y from the general population. Information on daily green tea consumption, psychological distress as assessed by the Kessler 6-item psychological distress scale, and other lifestyle factors was collected by using a questionnaire. We used multiple logistic regression analyses adjusted for age, sex, history of disease, body mass index, cigarette smoking, alcohol consumption, time spent walking, dietary factors, social support, and participation in community activities to investigate the relation between green tea consumption and psychological distress. Results: We classified 2774 (6.6%) of the respondents as having psychological distress ( Kessler 6-item psychological distress scale &gt;= 13/24). There was an inverse association between green tea consumption and psychological distress in a model adjusted for age and sex. Although the relation was largely attenuated when possible confounding factors were adjusted for, a statistically significant inverse association remained. The odds ratio ( with 95% CI) of developing psychological distress among respondents who consumed &gt;= 5 cups of green tea/d was 0.80 (0.70, 0.91) compared with those who consumed &lt;1 cup/d. These relations persisted when respondents were stratified by social support subgroups or by activities in communities. Conclusion: Green tea consumption was inversely associated with psychological distress even after adjustment for possible confounding factors. Am J Clin Nutr 2009;90:1390-6.

  297. Green tea and death from pneumonia in Japan: the Ohsaki cohort study 査読有り

    Ikue Watanabe, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Kaori Ohmori-Matsuda, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION 90 (3) 672-679 2009年9月

    出版者・発行元:AMER SOC NUTRITION-ASN

    DOI: 10.3945/ajcn.2009.27599  

    ISSN:0002-9165

    eISSN:1938-3207

    詳細を見る 詳細を閉じる

    Background: Experimental and animal studies have shown the activities of catechins, the main constituents of green tea, against infectious agents. No data are available on the association between green tea consumption and the risk of pneumonia in humans. Objective: We examined the association between green tea consumption and death from pneumonia in humans. Design: We conducted a population-based cohort study, with follow-up from 1995 to 2006. The participants were National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y). We excluded participants for whom data on green tea consumption frequency were missing or who had reported a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline. We used Cox proportional hazards regression analysis to calculate hazard ratios (HRs) and their 95% CIs for death from pneumonia according to green tea consumption. Results: Over 12 y of follow-up, we documented 406 deaths from pneumonia. In women, the multivariate HRs of death from pneumonia that were associated with different frequencies of green tea consumption were 1.00 (reference) for &lt;1 cup/d, 0.59 (95% CI: 0.36, 0.98) for 1-2 cups/d, 0.55 (95% CI: 0.33, 0.91) for 3-4 cups/d, and 0.53 (95% CI: 0.33, 0.83) for &gt;= 5 cups/d, respectively (P for trend: 0.008). In men, no significant association was observed. Conclusion: Green tea consumption was associated with a lower risk of death from pneumonia in Japanese women. Am J Clin Nutr 2009;90:672-9.

  298. Green Tea Consumption and Hematologic Malignancies in Japan 査読有り

    Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

    AMERICAN JOURNAL OF EPIDEMIOLOGY 170 (6) 730-738 2009年9月

    出版者・発行元:OXFORD UNIV PRESS INC

    DOI: 10.1093/aje/kwp187  

    ISSN:0002-9262

    詳細を見る 詳細を閉じる

    Several biologic studies have reported that green tea constituents have antitumor effects on hematologic malignancies. However, the effects in humans are uncertain. The authors used data from the Ohsaki National Health Insurance Cohort Study in Japan to evaluate the association between green tea consumption and the risk of hematologic malignancies. Study participants were 41,761 Japanese adults aged 40-79 years without a history of cancer at baseline who answered a food frequency questionnaire survey in 1994. During 9 years of follow-up beginning in 1995, the authors documented 157 hematologic malignancies, including 119 cases of lymphoid neoplasms and 36 cases of myeloid neoplasms. Hazard ratios were calculated by using the Cox proportional hazards regression model. Risk of hematologic malignancies was inversely associated with green tea consumption. The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). The corresponding risk estimate was 0.52 (95% confidence interval: 0.31, 0.87) for lymphoid neoplasms and 0.76 (95% confidence interval: 0.32, 1.78) for myeloid neoplasms. This inverse association was consistent across sex and body mass index strata. In conclusion, green tea consumption was associated with a lower risk of hematologic malignancies.

  299. Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma 査読有り

    Yukika Kakuta, Naoki Nakaya, Satoru Nagase, Megumi Fujita, Toshimitsu Koizumi, Chikako Okamura, Hitoshi Niikura, Kaori Ohmori, Shinichi Kuriyama, Toru Tase, Kiyoshi Ito, Yuko Minami, Nobuo Yaegashi, Ichiro Tsuji

    CANCER CAUSES & CONTROL 20 (5) 617-624 2009年7月

    出版者・発行元:SPRINGER

    DOI: 10.1007/s10552-008-9272-0  

    ISSN:0957-5243

    詳細を見る 詳細を閉じる

    To investigate the association between green tea consumption and the risk of endometrial cancer restricted to endometrial endometrioid adenocarcinoma (EEA) using a case-control design in Japan. The cases were 152 patients with histopathologically diagnosed EEA, and the controls were 285 healthy women who were matched for age and area of residence with individual cases. The subjects completed a questionnaire regarding health-related lifestyle and reproductive history, and a food frequency questionnaire. Odds ratios (ORs) of EEA for frequency of green tea consumption were calculated by conditional logistic regression analysis. We observed a significant inverse association between green tea consumption and the risk of EEA with a dose-response relationship. The multivariate-adjusted OR of EEA was 0.77 (95% CI: 0.37-1.58) for those in the second quartile of green tea consumption (5-6 cups/week-1 cup/day), 0.61 (0.30-1.23) in the third quartile (2-3 cups/day), and 0.33 (0.15-0.75) in the highest quartile (a parts per thousand yen4 cups/day), as referenced with those in the lowest quartile (a parts per thousand currency sign4 cups/week; p for trend = 0.007). This inverse association was consistently observed regardless of the presence or absence of factors such as obesity and menopause. Green tea consumption may be associated with a lower risk of EEA.

  300. Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study) 査読有り

    T. Shimazu, S. Kuriyama, K. Ohmori-Matsuda, N. Kikuchi, N. Nakaya, I. Tsuji

    INTERNATIONAL JOURNAL OF OBESITY 33 (4) 490-496 2009年4月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/ijo.2009.29  

    ISSN:0307-0565

    詳細を見る 詳細を閉じる

    Background: It is still unclear whether weight gain from early to late adulthood affects longevity. Furthermore, no study has addressed its association with all-cause and cause-specific mortality in an Asian population. Methods: We prospectively assessed the association between an increase in body mass index (BMI) category since age 20 years and risk of all-cause, cardiovascular disease (CVD) and cancer mortality. Self-reported information pertaining to BMI was collected from 38 080 Japanese men and women aged 40-79 years at study entry in 1994 after exclusion of participants with a BMI of &lt;18.5 kg/m(2) at age 20 years or at study entry. We defined six patterns of increase in BMI category at age 20 years and study entry: stable normal, overweight and obese, normal to overweight or obese, and overweight to obese. Results: During 7 years of follow-up, 2617 participants died. After adjustment for potential confounders, we observed a significantly increased risk of all-cause mortality for the pattern of normal weight at age 20 years and obese at study entry and of stable obese compared with stable normal in BMI category, the multivariate HRs (95% confidence interval (CI)) being 1.42 (1.08-1.88) and 2.26 (1.45-3.51), respectively. For the pattern of overweight at age 20 years and obese at study entry, the multivariate hazard ratio ( 95% CI) was 1.35 (0.92-1.98). In contrast, we did not observe an increased risk of all-cause mortality for normal weight at age 20 years and overweight at study entry, and stable overweight. For CVD and cancer mortality, these results were consistently observed. Conclusion: We observed an increased risk of all-cause mortality both among participants who had been persistently obese since early adulthood and participants who showed an increase in BMI category from normal to obese, compared with participants with a stable normal BMI category.

  301. Pain and Risk of Completed Suicide in Japanese Men: A Population-Based Cohort Study in Japan (Ohsaki Cohort Study) 査読有り

    Nobutaka Kikuchi, Kaori Ohmori-Matsuda, Taichi Shimazu, Toshimasa Sone, Masako Kakizaki, Naoki Nakaya, Shinichi Kuriyama, Ichiro Tsuji

    JOURNAL OF PAIN AND SYMPTOM MANAGEMENT 37 (3) 316-324 2009年3月

    出版者・発行元:ELSEVIER SCIENCE INC

    DOI: 10.1016/j.jpainsymman.2008.03.012  

    ISSN:0885-3924

    詳細を見る 詳細を閉じる

    Unrelieved pain is a major factor that influences suicide risk among terminally ill patients but, little is known about the relationship between pain and the risk of completed suicide in the general population. We prospectively examined the association between self-reports of pain and subsequent risk of completed suicide in 26,481 men aged 40 to 79 years from the Ohsaki National Health Insurance Cohort study, a population-based, prospective cohort study initiated in 1994. On the basis of a five-item. questionnaire on pain, individuals were classified as having no pain, very mild pain, mild pain, or moderate or severe., Pain. Completed suicide cases were documented from 1995 to 2001. During 131,027 person-years, 64 completed suicides were documented. After adjustment for covariates, the risk for completed suicide was significant, higher in the subjects with more pain. Multivariate hazard ratios (95% confidence intervals) relative to the subjects who bad no pain were 1.36 (0.67-2.75), 2.11 (1.02-4.33) and 2.93 (1.34-642) in the subjects who had who had very mild pain, mild pain, and moderate or severe Pain, respectively (P for trend = 0.004). Stratified analysis showed that the positive association between pain and suicide risk was robust M the subjects with good health, low stress, adequate steep, good physical activity, and no history of chronic diseases. Our results suggest that pain is associated with an increased risk of completed suicide among-Japanese men. The association was consistently observed among healthy subjects. J Pain Symptom Manage 2009;37:316-324. (C) 2009 U.S. Cancer, Pain, Relief Committee. Published by, Elsevier Inc. All rights reserved.

  302. Personality and Gastric Cancer Screening Attendance: A Cross-Sectional Analysis from the Miyagi Cohort Study 査読有り

    Shizuha Arai, Naoki Nakaya, Masako Kakizaki, Kaori Ohmori-Matsuda, Taichi Shimazu, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY 19 (1) 34-40 2009年1月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.JE20080024  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    Objective: To determine the associations between personality subscales and attendance at gastric cancer screenings in Japan. Methods: A total of 21,911 residents in rural Japan who completed a short form of the Eysenck Personality Questionnaire-Revised (EPQ-R) and a questionnaire on various health habits including the number of gastric cancer screenings attended were included in the primary analysis. We defined gastric cancer screening compliance as attendance at gastric cancer screening every year for the previous 5 years; all other patterns of attendance were defined as non-compliance. We defined gastric cancer screening visiting as attendance at 1 or more screenings during the previous 5 years; lack of attendance was defined as non-visiting. We used logistic regression to estimate the odds ratios (ORs) of gastric cancer screening compliance and visiting according to 4 score levels that corresponded to the 4 EPQ-R subscales (extraversion, neuroticism, psychoticism, and lie). Result: Extraversion had a significant linear, positive association with both compliance and visiting (trend, P &lt; 0.001 for both). Neuroticism had a significant linear, inverse association with compliance (trend, P = 0.047), but not with visiting (trend, P = 0.21). Psychoticisin had a significant linear, inverse association with both compliance and visiting (trend, P &lt; 0.001 for both). Lie had no association with either compliance or visiting. Conclusion: The personality traits of extraversion, neuroticism, and psychoticism were significantly associated with gastric cancer screening attendance. A better understanding of the association between personality and attendance could lead to the establishment of effective campaigns to motivate people to attend cancer screenings.

  303. Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan The Miyagi Cohort Study 査読有り

    Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Yoshikazu Nishino, Akira Fukao, Ichiro Tsuji

    AMERICAN JOURNAL OF EPIDEMIOLOGY 168 (12) 1425-1432 2008年12月

    出版者・発行元:OXFORD UNIV PRESS INC

    DOI: 10.1093/aje/kwn282  

    ISSN:0002-9262

    詳細を見る 詳細を閉じる

    An inverse association between coffee consumption and the risk of oral, pharyngeal, and esophageal cancers has been suggested in case-control studies, but few results from prospective studies are available. Data from the Miyagi Cohort Study in Japan were used to clarify the association between coffee consumption and the risk of these cancers. Information about coffee consumption was obtained from self-administered food frequency questionnaires in 1990. Among 38,679 subjects aged 40-64 years with no previous history of cancer, 157 cases of oral, pharyngeal, and esophageal cancers were identified during 13.6 years of follow-up. Hazard ratios were estimated by the Cox proportional hazards regression model. The risk of oral, pharyngeal, and esophageal cancers was inversely associated with coffee consumption. The multivariate-adjusted hazard ratio of these cancers for &gt; 1 cups of coffee per day compared with no consumption was 0.51 (95% confidence interval: 0.33, 0.77). This inverse association was consistent regardless of sex and cancer site and was observed both for subjects who did not drink or smoke and for those who currently drank or smoked at baseline. In conclusion, coffee consumption was associated with a lower risk of oral, pharyngeal, and esophageal cancers, even in the group at high risk of these cancers.

  304. No effect of the Trp64Arg variant of the beta(3)-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults 査読有り

    Shinichi Kuriyama, Taichi Shimazu, Atsushi Hozawa, Shigeo Kure, Naoyuki Kurokawa, Masako Kakizaki, Toshimasa Sone, Kaori Matsuda-Ohmori, Naoki Nakaya, Hiroshi Satoh, Ichiro Tsuji

    METABOLISM-CLINICAL AND EXPERIMENTAL 57 (11) 1570-1575 2008年11月

    出版者・発行元:W B SAUNDERS CO-ELSEVIER INC

    DOI: 10.1016/j.metabol.2008.06.013  

    ISSN:0026-0495

    詳細を見る 詳細を閉じる

    Controversy remains as to whether the presence of the tryptophan-to-arginine (Trp64Arg) variant of the beta(3)-adrenergic receptor gene impedes the magnitude of body weight loss by diet and exercise intervention. The objectives of the present study were to compare the changes in body weight between carriers and noncarriers of the Trp64Arg variant before and after 6 months of diet and exercise interventions for weight loss. A total of 37 middle-aged Japanese individuals (12 carriers and 25 noncarriers of the Trp64Arg variant) participated in the study. There were no significant differences in body weight between the 2 groups at the baseline. There were significant reductions in body weight both in carriers and noncarriers, but no significant differences between the 2 groups with respect to changes in these variables. The weight changes were -2.52 kg (95% confidence interval [CI], -3.56 to -1.48) among carriers and -1.89 kg (95% Cl, -2.65 to -1.13) among noncarriers, and the change in the variant carrier group minUS the change in the variant noncarrier group was -0.47 (95% Cl, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the beta(3)-adrenergic receptor gene may not play a major role as a hindrance to weight reduction. (C) 2008 Elsevier Inc. All rights reserved.

  305. Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study 査読有り

    M. Kakizaki, S. Kuriyama, T. Sone, K. Ohmori-Matsuda, A. Hozawa, N. Nakaya, S. Fukudo, I. Tsuji

    BRITISH JOURNAL OF CANCER 99 (9) 1502-1505 2008年10月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6604684  

    ISSN:0007-0920

    詳細を見る 詳細を閉じる

    In a prospective study of 23 995 Japanese women, short sleep duration was associated with higher risk of breast cancer (143 cases), compared with women who slept 7 h per day, the multivariate hazard ratio of those who slept &lt;= 6 h per day was 1.62 (95% confidence interval: 1.05 - 2.50; P for trend = 0.03).

  306. Marital status and non-small cell lung cancer survival: the Lung Cancer Database Project in Japan 査読有り

    Kumi Saito-Nakaya, Naoki Nakaya, Tatsuo Akechi, Masatoshi Inagaki, Mariko Asai, Koichi Goto, Kanji Nagai, Yutaka Nishiwaki, Shoichiro Tsugane, Shin Fukudo, Yosuke Uchitomi

    PSYCHO-ONCOLOGY 17 (9) 869-876 2008年9月

    出版者・発行元:JOHN WILEY & SONS LTD

    DOI: 10.1002/pon.1296  

    ISSN:1057-9249

    詳細を見る 詳細を閉じる

    Objective: Previous studies have suggested that marital status is associated with survival from lung cancer; however, its association is not conclusive. The association between marital status and survival in Japanese patients with non-small cell lung cancer (NSCLC) was prospectively investigated. Methods: Between July 1999 and July 2004, a total of 1230 NSCLC patients were enrolled. The baseline survey consisted of the collection of clinical information and various demographic data, including marital status. A Cox regression model was used to estimate the hazards ratio (HR) of all-cause mortality adjustments for age, BMI, education level, performance status, histology type, clinical stage, smoking status, choice of definitive treatment, and depression. Results: The multivariable adjusted HR of male widowed patients versus male married patients was 1.7 (95% confidence interval = 1.2 - 2.5, p = 0.005). However, no significant increased risk of death in female widowed patients compared with female married patients was observed (HR = 0.7, 95% confidence interval = 0.5 - 1.1, p = 0.15). With regard to separated/divorced and single patients no significant increased risk of death in male and/or female compared with married patients was observed. Conclusions: The present data suggest that male widowed patients with NSCLC have a higher mortality rate than male married patients with NSCLC, after controlling for various factors. Copyright (C) 2007 John Wiley & Sons, Ltd.

  307. Green tea consumption and lung cancer risk: the Ohsaki study 査読有り

    Q. Li, M. Kakizaki, S. Kuriyama, T. Sone, H. Yan, N. Nakaya, K. Mastuda-Ohmori, I. Tsuji

    BRITISH JOURNAL OF CANCER 99 (7) 1179-1184 2008年9月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6604645  

    ISSN:0007-0920

    詳細を見る 詳細を閉じる

    We examined the risk of lung cancer in relation to green tea consumption in a population-based cohort study in Japan among 41 440 men and women, aged 40-79 years, who completed a questionnaire in 1994 regarding green tea consumption and other health-related lifestyle factors. During the follow-up period of 7 years (from 1995 to 2001), 302 cases of lung cancer were identified, and the Cox proportional hazards regression model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). The multivariable-adjusted HRs of lung cancer incidence for green tea consumption of 1 or 2, 3 or 4, and 5 or more cups/day as compared to less than 1 cup/day were 1.14 (95% CI: 0.80-1.62), 1.18 (95% CI: 0.83-1.66), and 1.17 (95% CI: 0.85-1.61), respectively (P for trend 0.48). This cohort study has found no evidence that green tea consumption is associated with lung cancer.

  308. Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma 査読有り

    Toshimitsu Koizumi, Naoki Nakaya, Chikako Okamura, Yuki Sato, Taichi Shimazu, Satoru Nagase, Hitoshi Niikura, Shinichi Kuriyama, Toru Tase, Kiyoshi Ito, Yoshitaka Tsubono, Kunihiro Okamura, Nobuo Yaegashi, Ichiro Tsuj

    EUROPEAN JOURNAL OF CANCER PREVENTION 17 (4) 358-363 2008年8月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/CEJ.0b013e3282f0c02c  

    ISSN:0959-8278

    詳細を見る 詳細を閉じる

    This study examined the association between coffee consumption and the risk of endometrial endometrioid adenocarcinoma (EEA) in Japan by a case-control design. The cases consisted of 107 women less than 80 years of age from two medical centers who had been histopathologically diagnosed to have EEA. The controls, selected from the participants of a cancer-screening program, were 214 women, with two controls selected for each case (matched for age and for area of residence). A self-administered questionnaire containing questions to determine dietary and beverage consumption, as well as reproductive history, was distributed to the cases and controls. Conditional logistic regression analysis was used to estimate the odds ratio (OR) of EEA for three levels of coffee consumption with adjustment for potential confounding factors. The multivariate-adjusted OR of EEA for individuals in the highest tertile of coffee consumption (2 to 3 cups or more/day) was 0.4 [95% confidence interval (Cl), 0.2-0.9], and that of cases in the intermediate tertile (5 to 6 times/week-1 cup/day) was 0.6 (95% Cl, 0.3-1.2), relative to the individuals in the lowest tertile of coffee consumption (3 to 4 times or less/week) (P for trend = 0.014). The above association was observed in postmenopausal women (P for trend = 0.016), but not in premenopausal women (P for trend = 0.90). This study thus revealed an inverse dose-response relationship between coffee consumption and the risk of EEA, and its strong association in postmenopausal women but not in premenopausal women.

  309. 低栄養と介護保険認定・死亡リスクに関するコホート研究 鶴ヶ谷プロジェクト

    東口 みづか, 中谷 直樹, 大森 芳, 島津 太一, 曽根 稔雅, 寳澤 篤, 栗山 進一, 辻 一郎

    日本公衆衛生雑誌 55 (7) 433-439 2008年7月

    出版者・発行元:日本公衆衛生学会

    ISSN:0546-1766

    eISSN:2187-8986

    詳細を見る 詳細を閉じる

    目的 介護保険認定および死亡リスク予測の観点から、血清アルブミン値を特定高齢者の決定基準として用いる場合の基準値の妥当性を検討すること。方法 仙台市宮城野区鶴ヶ谷地区の70歳以上住民に対し、高齢者総合機能評価「寝たきり予防健診」を平成15年に行った。受診者のうち、同意が得られ介護保険認定非該当であった者832人を対象とした。血清アルブミンの基準値について、3.5g/dLから4.0g/dLまでの範囲で0.1g/dLごとに基準値を変化させて、各基準値以下群の介護保険認定および死亡リスク(Cox比例ハザードモデルにより算出)、該当率、感度、特異度、陽性反応適中度を算出し、基準値間で比較検討した。結果 3年間の追跡調査で、介護保険認定者111人、死亡者33人を確認した。重複者を除いた合計は130人であった。介護保険認定および死亡リスクは、血清アルブミン値3.5g/dLから4.0g/dLの基準値すべてで有意に上昇した。各基準値の該当率は、3.5g/dLで1.3%,3.8g/dLで9.6%,4.0g/dLで29.6%であった。感度は3.5g/dLで5.4%,3.8g/dLで18.5%,4.0g/dLで45.4%であった。特異度は3.5g/dLで99.4%,3.8g/dLで92.0%,4.0g/dLで73.4%であった。陽性反応適中度は3.5g/dLで63.6%,3.8g/dLで30.0%,4.0g/dLで24.0%であった。血清アルブミン値3.8g/dLを基準値とした時の、最大3分位群(4.4g/dL以上)をreferenceとした場合の性・年齢補正ハザード比(95%CI)は、基準値以下群(3.8g/dL以下)で2.1(1.1-3.9)、最小3分位群(3.9-4.1g/dL)で1.5(0.9-2.5)、中間3分位群(4.2-4.3g/dL)で1.0(0.6-1.7)であった。結論 該当率および感度、特異度の点から、血清アルブミン値3.8g/dLを基準値とすることの妥当性が示唆された。(著者抄録)

  310. Mass screening-based case-control study of diet and prostate cancer in Changchun, China 査読有り

    Xiao-Meng Li, Jiang Li, Ichiro Tsuji, Naoki Nakaya, Yoshikazu Nishino, Xue-Jian Zhao

    ASIAN JOURNAL OF ANDROLOGY 10 (4) 551-560 2008年7月

    出版者・発行元:MEDKNOW PUBLICATIONS & MEDIA PVT LTD

    DOI: 10.1111/j.1745-7262.2008.00384.x  

    ISSN:1008-682X

    eISSN:1745-7262

    詳細を見る 詳細を閉じる

    Aim: To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods: We carried out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value (&lt; 4.1 ng/mL) by 1: 10 according to age and place of employment. A case-control study of diet and prostate cancer was then carried out. Results: After adjustment for education, body mass index (BMI), smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio (OR) of 0.38 (95% confidence interval [CI], 0.13-1.12). In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 (95% CI, 0.11-0.79) compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer. Conclusion: Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer.

  311. Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study 査読有り

    M. Kakizaki, K. Inoue, S. Kuriyama, T. Sone, K. Matsuda-Ohmori, N. Nakaya, S. Fukudo, I. Tsuji

    BRITISH JOURNAL OF CANCER 99 (1) 176-178 2008年7月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6604425  

    ISSN:0007-0920

    詳細を見る 詳細を閉じる

    In a prospective study of prostate cancer incidence (127 cases), among 22 320 Japanese men, sleep duration was associated with lower risk; the multivariate hazard ratio of men who slept &gt;= 9 h per day compared with those who slept less was 0.48 (95% confidence interval: 0.29-0.79, P for trend = 0.02).

  312. Sense of life worth living (ikigai) and mortality in Japan: Ohsaki Study 査読有り

    Toshimasa Sone, Naoki Nakaya, Kaori Ohmori, Taichi Shimazu, Mizuka Higashiguchi, Masako Kakizaki, Nobutaka Kikuchi, Shinichi Kuriyama, Ichiro Tsuji

    PSYCHOSOMATIC MEDICINE 70 (6) 709-715 2008年7月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/PSY.0b013e31817e7e64  

    ISSN:0033-3174

    詳細を見る 詳細を閉じる

    Objective: To investigate the association between the sense of "life worth living (ikigai)" and the cause-specific mortality risk. The psychological factors play important roles in morbidity and mortality risks. However, the association between the negative psychological factors and the risk of mortality is inconclusive. Methods: The Ohsaki Study, a prospective cohort study, was initiated on 43,391 Japanese adults. To assess if the subjects found a sense of ikigai, they were asked the question, "Do you have ikigai in your life?" We used Cox regression analysis to calculate the hazard ratio of the all-cause and cause-specific mortality according to the sense of ikigai categories. Results: Over 7 years' follow-up, 3048 of the subjects died. The risk of all-cause mortality was significantly higher among the subjects who did not find a sense of ikigai as compared with that in the subjects who found a sense of ikigai; the multivariate adjusted hazard ratio (95% confidence interval) was 1.5 (1.3-1.7). As for the cause-specific mortality, subjects who did not find a sense of ikigai were significantly associated with an increased risk of cardiovascular disease (1.6; 1.3-2.0) and external cause mortality (1.9; 1.1-3.3), but not of the cancer mortality (1.3; 1.0-1.6). Conclusions: In this prospective cohort study, subjects who did not find a sense of ikigai were associated with an increased risk of all-cause mortality. The increase in mortality risk was attributable to cardiovascular disease and external causes, but not cancer.

  313. [Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project]. 査読有り

    Higashiguchi M, Nakaya N, Ohmori K, Shimazu T, Sone T, Hozawa A, Kuriyama S, Tsuji I

    [Nihon koshu eisei zasshi] Japanese journal of public health 55 433-439 2008年7月

    出版者・発行元:7

    DOI: 10.11236/jph.55.7_433  

    ISSN:0546-1766

  314. Negative psychological aspects and survival in lung cancer patients 査読有り

    Naoki Nakaya, Kumi Saito-Nakaya, Tatsuo Akechi, Shinichi Kuriyama, Masatoshi Inagaki, Nobutaka Kikuchi, Kanji Nagai, Shoichiro Tsugane, Yutaka Nishiwaki, Ichiro Tsuji, Yosuke Uchitomi

    PSYCHO-ONCOLOGY 17 (5) 466-473 2008年5月

    出版者・発行元:JOHN WILEY & SONS LTD

    DOI: 10.1002/pon.1259  

    ISSN:1057-9249

    詳細を見る 詳細を閉じる

    We conducted a prospective cohort study in Japan to investigate associations between negative psychological aspects and cancer survival. Between July 1999 and July 2004, a total of 1178 lung cancer patients were enrolled. The questionnaire asked about socioeconomic variables, smoking status, clinical symptoms, and psychological aspects after diagnosis. Negative psychological aspects were assessed for the subscales of helplessness/hopelessness and depression. Clinical stage, performance status (PS), and histologic type were obtained from medical charts. The subjects were followed up until December 2004, and 686 had died. A Cox regression model was used to estimate the hazards ratio (HR) of all-cause mortality. After adjustment for socioeconomic variables and smoking status in addition to sex, age, and histologic type, both helplessness/hopelessness and depression subscales showed significant linear positive associations with the risk of mortality (p for trend &lt; 0.001 for both). However, after adjustment for clinical state variables in addition to sex, age, and histologic type, these significant linear positive associations were no longer observed (P for trend = 0.41 and 0.26, respectively). Our data supported the hypothesis that the association between helplessness/hopelessness and depression and the risk of mortality among lung cancer patients was largely confounded by clinical state variables including clinical stage, PS, and clinical symptoms. Copyright (C) 2007 John Wiley & Sons, Ltd.

  315. Association between nocturia and fractures in a community-dwelling elderly population aged 70 years and over: Results of a 3-year prospective cohort study in Japan 査読有り

    Haruo Nakagawa, Yoshihiro Ikeda, Yasuhiro Kaiho, Naoki Nakaya, Kaori Omori, Kaun Niu, Shinichi Kuriyama, Ryoichi Nagatomi, Ichiro Tsuji, Ydichi Arai

    JOURNAL OF UROLOGY 179 (4) 143-143 2008年4月

    出版者・発行元:ELSEVIER SCIENCE INC

    DOI: 10.1016/S0022-5347(08)60410-3  

    ISSN:0022-5347

  316. Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: A population-based, cross-sectional analysis 査読有り

    Kaijun Niu, Atsushi Hozawa, Shuichi Awata, Hui Guo, Shinichi Kuriyama, Toru Sek, Kaori Ohmori-Matsuda, Naoki Nakaya, Satoru Ebihara, Yun Wang, Ichiro Tsuji, Ryoichi Nagatomi

    HYPERTENSION RESEARCH 31 (3) 409-416 2008年3月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1291/hypres.31.409  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    Although several epidemiologic studies have assessed the relationship between low blood pressure and depressive symptoms in geriatric populations, the results have been inconsistent. Because the white-coat phenomenon is observed frequently in patients with depressive symptoms, we have considered that blood pressure measured in nonmedical settings is important in assessing the relationship between blood pressure and depressive symptoms among the geriatric population. The aim of this study was to investigate the relationships between home blood pressure and depressive symptoms in a community-based elderly population aged 70 years and over. We analyzed a cross-sectional survey comprised of 888 community-dwelling Japanese aged 70 years and older. Blood pressure was self-measured at home, and depressive symptoms were evaluated using the 30-item Geriatric Depression Scale (GDS 30) with a cutoff point of 11. The prevalence of depressive symptoms was 34.8%. For all subjects, after adjustments for potentially confounding factors, the odds ratios of having depressive symptoms by increasing quartiles of systolic blood pressure of subjects not taking antihypertensive drugs to subjects taking them were 1.00, 0.97, 0.88, 0.59, and 0.70. Statistically significant inverse relationships were observed in subjects not taking anti hypertensive drugs. No apparent association between diastolic blood pressure and depressive symptoms was observed in any subjects or in a stratified analysis of antihypertensive drug use. In this study, a higher home systolic blood pressure was independently and continuously related to a lower prevalence of depressive symptoms in participants not using anti hypertensive medication. Further study is required to clarify the causality of this relationship.

  317. Survey of the current status of cancer rehabilitation in Japan 査読有り

    Toyohiro Hamaguchi, Hitoshi Okamura, Naoki Nakaya, Kazunari Abe, Yasushi Abe, Shino Umezawa, Miho Kurihara, Kumi Nakaya, Kinomi Yomiya, Yosuke Uchitomi

    DISABILITY AND REHABILITATION 30 (7) 559-564 2008年

    出版者・発行元:TAYLOR & FRANCIS LTD

    DOI: 10.1080/09638280701377003  

    ISSN:0963-8288

    詳細を見る 詳細を閉じる

    Purpose. To elucidate the current status of cancer rehabilitation in institutions nationwide. Method. A questionnaire survey regarding the current status of cancer rehabilitation in 1693 healthcare institutions was conducted by mail. The survey first asked whether rehabilitation was being conducted for cancer patients and, in facilities in which it was being conducted, it then asked about the content of the rehabilitation, the stage of the cancer patients, etc. Facilities in which cancer rehabilitation was not being conducted were surveyed in regard to whether there was a need for cancer rehabilitation. Results. Valid replies were obtained from 1045 (62.0%) institutions and 864 (82.7%) of them conducted rehabilitation for cancer patients. A high proportion of the content of the rehabilitation was found to be related to physical function. Activities of daily living guidance and training were also found to be conducted in a high proportion. Low proportions of the facilities conducted content that was specialized for cancer. Of the 181 facilities in which rehabilitation was not being conducted for cancer patients, 171 (94.5%) replied that they felt that rehabilitation was needed for cancer patients. Conclusions. Based on the results of this fact-finding survey it will be necessary to consider strategies for popularizing and developing rehabilitation programmes for cancer patients in Japan.

  318. Personality and body mass index: A cross-sectional analysis from the Miyagi Cohort Study 査読有り

    Masako Kakizaki, Shinichi Kuriyarna, Yuki Sato, Taichi Shimazu, Kaori Matsuda-Ohmori, Naoki Nakaya, Akira Fukao, Shin Fukudo, Ichiro Tsuji

    JOURNAL OF PSYCHOSOMATIC RESEARCH 64 (1) 71-80 2008年1月

    出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD

    DOI: 10.1016/j.jpsychores.2007.07.008  

    ISSN:0022-3999

    詳細を見る 詳細を閉じる

    Objective: Obesity is an increasingly prevalent public health problem worldwide, and is associated with a higher risk of developing various noncommunicable diseases. To further examine the association between personality and overweight, obesity, or underweight, we conducted a cross-sectional analysis in Japan. We hypothesized that extraversion and psychoticism would have a positive association with overweight, and that neuroticism and lie would have an inverse association with overweight, whereas the association between personality and underweight would be the reverse image of overweight. Methods: In 1990, 30,722 subjects (40-64 years of age) completed a self-administered questionnaire including body weight and height and the Japanese version of the Eysenck Personality Questionnaire-Revised Short Form. Multivariate logistic regression analysis was used to calculate odds ratios for overweight [body mass index (BMI)&gt;= 25.0 kg/m(2)] or underweight (BMI &lt; 18.5) relative to each category on the personality subscale. Results: In men and women, extraversion and psychoticism had positive associations with overweight, whereas neuroticism had an inverse association. Lie had an inverse association with overweight in men. In men and women, only extraversion had an inverse association with underweight and neuroticism had a positive association with underweight. Conclusion: Our findings indicate that personality is associated with both overweight and underweight. These results may provide clues to devising more effective measures for preventing overweight, obesity, or underweight or for weight control intervention. (c) 2008 Elsevier Inc. All rights reserved.

  319. Fish intake and the risk of prostate cancer in Japan: A prospective cohort study 査読有り

    Fumi Sato, Taichi Shimazu, Shinichi Kuriyama, Kaori Ohmori, Naoki Nakaya, Ichiro Tsuji, Yoichi Arai

    Japanese Journal of Urology 99 (1) 14-21 2008年

    出版者・発行元:Japanese Urological Association

    DOI: 10.5980/jpnjurol1989.99.14  

    ISSN:0021-5287

    詳細を見る 詳細を閉じる

    (Objective) Fish intake may reduce the risk of prostate cancer. However, the results of previous prospective cohort studies have been inconsistent, and almost all have been undertaken in Western countries, where total fish intake is low. We therefore investigated the association between fish intake and the risk of prostate cancer in a prospective cohort study in Japan. (Participants and methods) We delivered a self-administered questionnaire including items on dietary intake (40-item food frequency questionnaire [FFQ] ), and various lifestyle habits, between October and December 1994 to all male National Health Insurance (NHI) beneficiaries aged 40-79 years in Japan. Usable questionnaires were returned from 24,895 (94%) of the participants. We divided the participants into quartiles based on their self-reported fish intake. We used the Cox proportional hazards model to estimate the hazard ratio (HR) and 95% confidence interval (CI) of prostate cancer incidence according to fish intake, after adjustment for potential confounders. (Results) We identified 95 prostate cancer cases during 7 years of follow-up, to the end of December 2001. An inverse association was observed between fish intake and the risk of prostate cancer. The multivariate HRs (95% CI) of prostate cancer across increasing quartiles of fish intake were 1.00, 0.92 (0.48-1.76), 0.73 (0.42-1.28), and 0.72 (0.40-1.33) (P for trend = 0.23). Among participants aged 40-69 years, the multivariate HRs (95% CI) of prostate cancer across increasing quartiles of fish intake were 1.00,1.26 (0.51-3.11 ), 0.86 (0.38-1.94), and 1.01 (0.43-2.34) (P for trend = 0.83). On the other hand, among participants aged 70 years or older, the corresponding multivariate HRs (95% CI) were 1.00,0.63 (0.23-1.69), 0.60 (0.27-1.30), and 0.44 (0.18-1.11) (P for trend = 0.08). (Conclusions) The risk of prostate cancer tended to decrease among those aged 70 years or older although it was not significant. The relation was not seen in those aged 40-69 years old.

  320. Serum C-Reactive Protein Even at Very Low (&lt; 1.0 mg/l) Concentration Is Associated with Physical Performance in a Community-Based Elderly Population Aged 70 Years and Over 査読有り

    Kaijun Niu, Atsushi Hozawa, Hui Guo, Shinichi Kuriyama, Satoru Ebihara, Guang Yang, Kaori Ohmori-Matsuda, Naoki Nakaya, Hideko Takahashi, Kazuki Fujita, Shirong Wen, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    GERONTOLOGY 54 (5) 260-267 2008年

    出版者・発行元:KARGER

    DOI: 10.1159/000134286  

    ISSN:0304-324X

    詳細を見る 詳細を閉じる

    Background: Although several studies have reported that C-reactive protein (CRP) is associated with physical performance, few studies have evaluated the relationships between CRP and physical performance among subjects who had a very low range of CRP. Therefore, it is still unclear whether a lower CRP is favorably associated with physical performance even within a very low range. Objective: The aim of this study was to investigate the relationships between CRP and physical performance among a Japanese population with a low serum CRP concentration (CRP &lt;1.0 mg/l). Methods: We designed a cross-sectional survey for 775 persons aged 70 years and older living in Japan. High-sensitivity CRP was measured using a nephelometric method. The subjects whose serum CRP concentrations were higher than 10.0 mg/l were excluded. Physical performance was assessed using a 10-meter maximum walk test, leg extension power, and a timed &apos;up and go&apos; test. Results: The median value ( interquartile range) of CRP was 0.55 (0.29-1.20) mg/l. After adjustment for potential confounding factors, an inverse relation of CRP with the 10-meter maximum walk test and leg power was observed in all subjects (p for trend = 0.10 and 0.04, respectively). For subjects who had a CRP &lt;1.0 mg/l, these inverse relations were unchanged (p for trend = 0.03 and 0.02, respectively). Conclusions: Serum CRP concentration is favorably related to physical performance, even within a very low range in a community-based elderly population aged 70 years and over. The findings suggest that maintaining as low CRP levels as possible may potentially maintain better physical performance. Copyright (C) 2008 S. Karger AG, Basel

  321. Alcohol consumption and suicide mortality among Japanese men: the Ohsaki Study 査読有り

    Naoki Nakaya, Nobutaka Kikuchi, Taichi Shimazu, Kaori Ohmori, Masako Kakizaki, Toshimasa Sone, Shuichi Awata, Shinichi Kuriyama, Ichiro Tsuji

    ALCOHOL 41 (7) 503-510 2007年11月

    出版者・発行元:ELSEVIER SCIENCE INC

    DOI: 10.1016/j.alcohol.2007.08.001  

    ISSN:0741-8329

    詳細を見る 詳細を閉じる

    The risk of suicide is well known to be increased among heavy alcohol drinkers. However, whether the risk is increased or decreased among light drinkers is still under debate. We investigated this association in a population-based sample of men in Japan. The Ohsaki Study was a population-based, prospective cohort study among Japanese adults aged from 40 to 79 years. Between October and December, 1994, 22,804 men in Miyagi Prefecture, Japan, completed a questionnaire on various health-related lifestyles, including alcohol drinking. During the subsequent 7 years follow-up, 73 participants committed suicide. We used the Cox proportional hazards regression model to estimate the hazard ratio (HR) for suicide mortality according to the quantity of alcohol consumed daily, with adjustment for potential confounders. There was a statistically significant positive and linear association between the amount of alcohol consumed and the risk of suicide: the multivariate HRs in reference to nondrinkers (95% confidence interval) were 1.2 (0.5-2.7), 1.5 (0.7-3.4), and 2.4 (1.2-4.6) in current drinkers who consumed &lt;= 22.7 g, 22.8 g-45.5 g, and &gt;= 45.6 g of alcohol per day, respectively (P-trend = .016). Even after the early death cases were excluded, a significant linear association was observed between alcohol consumption and the risk of suicide, with the risk of suicide also being nonsignificantly higher among the light drinkers than among nondrinkers (multivariate HR = 1.7). This prospective cohort study indicated a positive linear association between alcohol consumption and the risk of suicide, and the suicide risk among the light drinkers was not decreased as compared with that in nondrinkers. (c) 2007 Elsevier Inc. All rights reserved.

  322. Time spent walking and risk of colorectal cancer in Japan: The Miyaqi Cohort Study 査読有り

    Hideko Takahashi, Shinichi Kuriyama, Yoshitaka Tsubono, Naoki Nakaya, Kazuki Fujita, Yoshikazu Nishino, Daisuke Shibuya, Ichiro Tsuji

    EUROPEAN JOURNAL OF CANCER PREVENTION 16 (5) 403-408 2007年10月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/01.cej.0000236249.63489.05  

    ISSN:0959-8278

    詳細を見る 詳細を閉じる

    Higher levels of physical activity have been consistently associated with a lower risk of colon cancer in earlier epidemiological studies. The specific benefits of walking, however, remain relatively unexplored. In 1990, 20 519 men and 21469 women in Japan completed a self-administered questionnaire including a question on time spent walking per day. During 7 years of follow-up, 260 cases of colorectal cancer were documented in 305 790 person-years. We used the Cox proportional hazards regression model to estimate the relative risk of incident cancer (colorectal, colon, and rectal) according to three levels of walking. Time spent walking was inversely associated with risk of colorectal cancer incidence in men. Compared with men who walked 0.5 h or less per day, the multivariate relative risks were 1.06 (95% confidence interval 0.72-1.57) for men who walked between 0.5 and 1 h per day, and 0.57 (95% confidence interval 0.38-0.83) for men who walked 1 h or more per day (P for trend=0.003). Time spent walking per day was associated with a lower risk of colon cancer in Japanese men but not in women, and there was no association between time spent walking and the risk of rectal Cancer.

  323. Extensive gastric atrophy: An increased risk factor for superficial esophageal squamous cell carcinoma in Japan 査読有り

    Katsunori Iijima, Tomoyuk Koike, Yasuhiko Abe, Yoshifumi Inomata, Hitoshi Sekine, Akira Imatani, Naoki Nakaya, Shuichi Ohara, Tooru Shimosegawa

    AMERICAN JOURNAL OF GASTROENTEROLOGY 102 (8) 1603-1609 2007年8月

    出版者・発行元:BLACKWELL PUBLISHING

    DOI: 10.1111/j.1572-0241.2007.01257.x  

    ISSN:0002-9270

    詳細を見る 詳細を閉じる

    Objectives: A recent study in Sweden has reported that gastric atrophy is associated with an increased risk for esophageal squamous cell carcinoma. However, this finding needs to be confirmed in other ethnic groups due to the wide geographic variation of this cancer. Objectives: To investigate whether gastric atrophy is associated with a risk for esophageal squamous cell carcinoma using a case-control study in Japanese subjects, a population known to have a high prevalence of H. pylori infection and accompanying gastric atrophy. Methods: Seventy-three patients who had undergone endoscopic mucosal resection for superficial esophageal squamous cell carcinoma, and 73 sex- and age-matched controls, were enrolled prospectively. Gastric fundic atrophy was evaluated by histology of biopsy specimens and serum pepsinogen I level (cutoff level 25 ng/mL). Conditional logistic regression model with adjustment for potential confounding factors was used to assess the associations. Results: Gastric atrophy, defined histologically or serologically, was independently associated with an increased risk for esophageal squamous cell carcinoma and the risk seemed to increase with the progression of the atrophy. Multivariate odds ratio (95% confidence interval) for histological fundic atropy, fundic intestinal metaplasia, and serological atrophy are 4.2 (1.5-11.7), 10.7 (2.3-50.4), and 8.2 (2.2-30.4), respectively. Conclusions: Gastric atrophy, a newly recognized risk factor for esophageal squamous cell carcinoma in Sweden, is likely to be a risk factor in other areas. Further studies are warranted to explore the causal relationship.

  324. Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study 査読有り

    Taichi Shimazu, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori, Yuki Sato, Naoki Nakaya, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 36 (3) 600-609 2007年6月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/ije/dym005  

    ISSN:0300-5771

    詳細を見る 詳細を閉じる

    Background Although ecological observations suggest that the Japanese diet may reduce the risk of cardiovascular disease (CVD), the impact of a Japanese dietary pattern upon mortality due to CVD is unclear. Methods We prospectively assessed the association between dietary patterns among the Japanese and CVD mortality. Dietary information was collected from 40 547 Japanese men and women aged 40-79 years without a history of diabetes, stroke, myocardial infarction or cancer at the baseline in 1994. Results During 7 years of follow-up, 801 participants died of CVD. Factor analysis (principal component) based on a validated food frequency questionnaire identified three dietary patterns: (i) a Japanese dietary pattern highly correlated with soybean products, fish, seaweeds, vegetables, fruits and green tea, (ii) an 'animal food' dietary pattern and (iii) a high-dairy, high-fruit-and-vegetable, low-alcohol (DFA) dietary pattern. The Japanese dietary pattern was related to high sodium intake and high prevalence of hypertension. After adjustment for potential confounders, the Japanese dietary pattern score was associated with a lower risk of CVD mortality (hazard ratio of the highest quartile vs the lowest, 0.73; 95% confidence interval: 0.59-0.90; P for trend= 0.003). The 'animal food' dietary pattern was associated with an increased risk of CVD, but the DFA dietary pattern was not. Conclusion The Japanese dietary pattern was associated with a decreased risk of CVD mortality, despite its relation to sodium intake and hypertension.

  325. Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan 査読有り

    Toru Naganuma, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Matsuda-Ohmori, Taichi Shimazu, Akira Fukao, Ichiro Tsuji

    INTERNATIONAL JOURNAL OF CANCER 120 (7) 1542-1547 2007年4月

    出版者・発行元:WILEY-LISS

    DOI: 10.1002/ijc.22505  

    ISSN:0020-7136

    詳細を見る 詳細を閉じる

    An inverse association between coffee consumption and the risk of colorectal cancer has been reported in several case-control studies, but results from prospective cohort studies have been inconclusive. We conducted a prospective cohort study among a Japanese population to clarify the association between coffee consumption and the risk of colorectal cancer incidence. We used data from the Miyagi Cohort Study for this analysis. Usable self-administered questionnaires about coffee consumption were returned from 22,836 men and 24,769 women, aged 40-64 years, with no previous history of cancer. We used the Cox proportional-hazard regression model to estimate hazard ratios and 95% confidence intervals. During 11.6 years of follow-up (425,303 person-years), we identified 457 cases of colorectal cancer. Coffee consumption was not associated with the incidence of colorectal, colon or rectal cancer. The multivariate-adjusted hazard ratio (95% confidence interval) of colorectal cancer incidence for 3 or more cups of coffee per day as compared with no consumption was 0.95 (0.65-1.39) for men and women (p for trend = 0.55), 0.91 (0.56-1.46) for men (p for trend = 0.53) and 1.16 (0.60-2.23) for women (p for trend = 0.996). Coffee consumption was also not associated with incidence of either proximal or distal colon cancer. We conclude that coffee consumption is not associated with the incidence risk of colorectal cancer in the general population in Japan. (c) 2007 Wiley-Liss, Inc.

  326. The joint impact of cardiovascular risk factors upon medical costs 査読有り

    Kaori Ohmori-Matsuda, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Taichi Shimazu, Ichiro Tsuji

    PREVENTIVE MEDICINE 44 (4) 349-355 2007年4月

    出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE

    DOI: 10.1016/j.ypmed.2006.11.020  

    ISSN:0091-7435

    詳細を見る 詳細を閉じる

    Objective. The joint impact of obesity, hypertension, and hyperglycemia upon medical costs is not well known. Our objective was to evaluate the joint impact of these cardiovascular risk factors upon medical costs in the rural Japanese population. Methods. The data were derived from a 6-year prospective observation of National Health Insurance beneficiaries in rural Japan. Data on blood chemistry tests, blood pressure, weight, and height were obtained from an annual health check-up provided by the local municipalities in 1995. We prospectively collected data on medical costs over a 6-year period for 12,340 subjects (5306 men and 7034 women) without prior histories of cardiovascular disease or cancer. Results. Mean medical costs for individuals being overweight/obese, hypertensive, and hyperglycemic were 91.0% higher than those for individuals without any of these three cardiovascular risk factors. In this cohort, 17.2% of total medical costs were attributable to these three risk factors. Conclusion. Overweight/obesity, hypertension, and hyperglycemia could have a large impact on health care resources in rural Japan. (C) 2006 Elsevier Inc. All rights reserved.

  327. Cigarette smoking and the risk of colorectal cancer among men: a prospective study in Japan 査読有り

    Munlra Akhter, Yoshikazu Nishino, Naoki Nakaya, Kayoko Kurashima, Yuki Sato, Shinichi Kuriyama, Yoshitaka Tsubono, Ichiro Tsuji

    EUROPEAN JOURNAL OF CANCER PREVENTION 16 (2) 102-107 2007年4月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/01.cej.0000228412.98847.bc  

    ISSN:0959-8278

    詳細を見る 詳細を閉じる

    The association between cigarette smoking and the risk of colorectal cancer remains controversial. We examined this association using a population-based prospective cohort study in Miyagi, Japan. In 1990, we delivered a self-administered questionnaire on cigarette smoking and other health habits to 25279 men who were 40-64 years of age and lived in 14 municipalities of Miyagi Prefecture. A total of 22836 men responded (90.3% response rate). During 7 years of follow-up (158376 person-years), we identified 188 patients of colorectal cancer. Relative risks and 95% confidence intervals were estimated by the Cox proportional-hazards regression analysis with adjustment for potential confounders. The multivariate-adjusted relative risks (95% confidence interval) of colorectal cancer for past smokers and current smokers compared with those who had never smoked were 1.73 (1.04-2.87) and 1.47 (0.93-2.34), respectively. Among current smokers, both a higher number of cigarettes smoked per day and an earlier age at which smoking had started were associated with a significant linear increase in risk (P for trend &lt; 0.05). Our findings are consistent with the hypothesis that cigarette smoking is associated with a higher risk of colorectal cancer in men.

  328. Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community residents 査読有り

    S. Awata, P. Bech, Y. Koizum, T. Seki, S. Kuriyama, A. Hozawa, K. Ohmori, N. Nakaya, H. Matsuoka, I. Tsuji

    INTERNATIONAL PSYCHOGERIATRICS 19 (1) 77-88 2007年2月

    出版者・発行元:CAMBRIDGE UNIV PRESS

    DOI: 10.1017/S1041610206004212  

    ISSN:1041-6102

    詳細を見る 詳細を閉じる

    Objective: The aim of this study is to evaluate the validity and the utility of the Japanese version of the WHO-Five Well-Being Index (WHO-5-J) in the context of detecting suicidal ideation in elderly community residents. Methods: A sample of 696 subjects aged 70 years or over who completed a set of questionnaires was examined. Results: Cronbach&apos;s alpha was 0.87 and Loevinger&apos;s coefficient was 0.64. The total score was significantly correlated with the number of cohabitants, the number of physical illnesses, physical functioning, instrumental activities of daily living, and depressive symptoms. Subjects with suicidal ideation had significantly lower scores on the WHO-5-J. The receiver-operating characteristic curve analysis indicated that the scale significantly discriminated the subjects with suicidal ideation. When combined with the assessment of a lack of perceived social support (PSS), a standard cut-off criterion of "a total score &lt; 12 or answering 0 or 1 to any of the five items" more appropriately identified elderly subjects with suicidal ideation: sensitivity = 87%, specificity = 75%, negative predictive value = 99%, and positive predictive value = 10%. Conclusions: In combination with PSS, the scale has predictive utility to detect suicidal ideation in elderly community residents.

  329. Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: A population-based cohort study 査読有り

    Akira Miyamoto, Shinichi Kuriyama, Yoshikazu Nishino, Yoshitaka Tsubono, Naoki Nakaya, Kaori Ohmori, Kayoko Kurashima, Daisuke Shibuya, Ichiro Tsuji

    PREVENTIVE MEDICINE 44 (1) 12-19 2007年1月

    出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE

    DOI: 10.1016/j.ypmed.2006.07.016  

    ISSN:0091-7435

    詳細を見る 詳細を閉じる

    Objective. This study aimed to investigate the association between gastric cancer screening and mortality from gastric cancer. Methods. In 1990, 47,605 Japanese subjects were recruited and completed a questionnaire about participation in gastric cancer screening and lifestyle. We followed up their vital status through December 2001. In this cohort, 41,394 subjects without a history of cancer were allocated to the screened group or the unscreened group according to their response to the question about gastric cancer screening. We estimated the relative risk (RR) of death from gastric cancer, death from any cause except gastric cancer, and incidence of gastric cancer with adjustment for potential confounding variables. Results. The risk of death from gastric cancer among the screened group was significantly lower than that among the unscreened group. The multivariate RR of death from gastric cancer for screened individuals compared with those not screened was 0.54 (95% confidence interval [Cl]: 0.38, 0.77). The RR of death from any cause except gastric cancer was 0.83 (95% Cl: 0.77, 0.90), and the RR of incidence of gastric cancer was 0.94 (95% Cl: 0.79, 1.13). Conclusion. Our data suggest that gastric cancer screening or factors associated with it may be associated with lower mortality from gastric cancer. (c) 2006 Published by Elsevier Inc.

  330. Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: The Miyagi Cohort Study 査読有り

    Munira Akhter, Shinichi Kuriyama, Naoki Nakaya, Taichi Shimazu, Kaori Ohmori, Yoshikazu Nishino, Yoshitaka Tsubono, Akira Fukao, Ichiro Tsuji

    EUROPEAN JOURNAL OF CANCER 43 (2) 383-390 2007年1月

    出版者・発行元:ELSEVIER SCI LTD

    DOI: 10.1016/j.ejca.2006.09.020  

    ISSN:0959-8049

    詳細を見る 詳細を閉じる

    The association between alcohol consumption and the risk of cancer of the proximal or-distal colon or rectum remains controversial. We examined this association in a large population-based cohort of Japanese men. In 1990, a self-administered questionnaire on alcohol drinking and other health habits was delivered to 25,279 Japanese men aged 40 to 64 years of age. After exclusion of subjects who gave incomplete responses on alcohol drinking or prevalent cancer cases at the baseline, a total of 21,199 men remained. Of these, 307 men were diagnosed as having colorectal cancer after 11 years of follow-up. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), with adjustments made for potential confounders. Compared with never drinkers, past and current drinkers had multivariate HRs of 1.1 (95% CI, 0.6-1.9) and 1.6 (95% CI, 1.1-2.2) for colorectal cancer, respectively A dose-response relationship with current volume of alcohol drinkers was observed for cancer of the distal colon and rectum, but not for proximal colon. The multivariate HRs for distal colon and rectal cancer among current heavy drinkers (45.6 g or more ethanol per day) as compared with never drinkers were 4.2 (1.6-10.7; p for trend = 0.0002) and 1.8 (1.1-3.2; p for trend = 0.04), respectively. In contrast, no significant linear association was found for proximal colon cancer (p for trend = 0.2). These data indicate that alcohol consumption in Japanese men is associated with a statistically significant increased risk of cancer of the distal colon and rectum, but not cancer of the proximal colon. (c) 2006 Elsevier Ltd. All rights reserved.

  331. Psychometric properties of the Japanese version of the quality of life-Cancer Survivors Instrument 査読有り

    Maiko Fujimori, Makoto Kobayakawa, Naoki Nakaya, Kanji Nagai, Yutaka Nishiwaki, Masatoshi Inagaki, Yosuke Uchitomi

    QUALITY OF LIFE RESEARCH 15 (10) 1633-1638 2006年12月

    出版者・発行元:SPRINGER

    DOI: 10.1007/s11136-006-0038-4  

    ISSN:0962-9343

    詳細を見る 詳細を閉じる

    The purpose of this study was to describe the psychometric properties of the Japanese version of the Quality of Life-Cancer Survivors Instrument (QOL-CS-J) developed in the U. S. This study was conducted as a mail survey to survivors of more than 5 years post curative resection for non-small-cell lung cancer (NSCLC) and who had participated in an earlier survey. This survey included the medical and demographic factors, the QOL-CS scores, and the Medical Outcome Study 36-Item Short Form (SF-36). A total of 113 survivors completed the survey. To confirm the reliability, the Cronbach's alpha coefficient of each subscale was calculated as an internal consistency (alpha = 0.65-0.89). To confirm the validity of the trial as conducted, Pearson's correlation coefficients between the subscales of the QOL-CS and the subscales of the SF-36 were calculated. There were moderate correlations between associated subscales including QOL-CS physical to SF-36 bodily pain (r = 0.45) and vitality (r = 0.52), QOL-CS psychological to SF-36 mental health (r = 0.55), QOL-CS social to SF-36 general health perception (r = 0.31) and mental health (r = 0.47), and QOL-CS total to each subscale of SF-36 (r = 0.25-0.64). Findings demonstrated that the QOL-CS-J adequately measured the QOL in long-term NSCLC survivors.

  332. Impact of non-dietary nutrients intake on misclassification in the estimation of nutrient intake in epidemiologic study 査読有り

    Mikiko Ogata, Shinichi Kuriyama, Yuki Sato, Taichi Shimazu, Naoki Nakaya, Kaori Ohmori, Atsushi Hozawa, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY 16 (5) 193-200 2006年9月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.16.193  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BACKGROUND: Few previous epidemiologic studies have evaluated the effects of non-dietary nutrient intake, such as supplements, over the counter (OTC) drugs, and prescription drugs containing vitamins or minerals, in examining the relationship between dietary factors and health outcomes. METHODS: To examine the influence of the non-dietary intake of vitamins and calcium on the estimation of nutrient intake, we conducted a cross-sectional study with 1, 168 community-dwelling Japanese subjects aged 70 years or older in 2002. The subjects were asked to bring their non-dietary nutrient sources to the examining site. The dietary and non-dietary intakes of vitamins B-1, C, E and calcium were obtained and the subjects were grouped into quartiles according to their dietary intake and their dietary plus non-dietary intake. The degree of agreement between these two classifications was examined to estimate the degree of misclassification. RESULTS: Among the subjects who were classified into the highest intake category for vitamin E with dietary intake plus non-dietary nutrient intake, 34.2% were misclassified into lower category with dietary intake alone. Similarly, intake of vitamin B-1, vitamin C and calcium were misclassified 28.8%, 18.8%, 6.2%, respectively. CONCLUSIONS: Our data suggest that estimation of vitamin intake from dietary sources alone would yield a maximum misclassification of one-third, which would lead to misleading conclusions being drawn from epidemiologic studies. In contrast, the degree of misclassification for calcium may be relatively small.

  333. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan - The Ohsaki Study 査読有り

    Shinichi Kuriyama, Taichi Shimazu, Kaori Ohmori, Nobutaka Kikuchi, Naoki Nakaya, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 296 (10) 1255-1265 2006年9月

    出版者・発行元:AMER MEDICAL ASSOC

    DOI: 10.1001/jama.296.10.1255  

    ISSN:0098-7484

    詳細を見る 詳細を閉じる

    Context Green tea polyphenols have been extensively studied as cardiovascular disease and cancer chemopreventive agents in vitro and in animal studies. However, the effects of green tea consumption in humans remain unclear. Objective To investigate the associations between green tea consumption and all-cause and cause-specific mortality. Design, Setting, and Participants The Ohsaki National Health Insurance Cohort Study, a population-based, prospective cohort study initiated in 1994 among 40 530 Japanese adults aged 40 to 79 years without history of stroke, coronary heart disease, or cancer at baseline. Participants were followed up for up to 11 years (1995-2005) for all-cause mortality and for up to 7 years (1995-2001) for cause-specific mortality. Main Outcome Measures Mortality due to cardiovascular disease, cancer, and all causes. Results Over 11 years of follow-up (follow-up rate, 86.1%), 4209 participants died, and over 7 years of follow-up (follow-up rate, 89.6%), 892 participants died of cardiovascular disease and 1134 participants died of cancer. Green tea consumption was inversely associated with mortality due to all causes and due to cardiovascular disease. The inverse association with all-cause mortality was stronger in women (P = .03 for interaction with sex). In men, the multivariate hazard ratios of mortality due to all causes associated with different green tea consumption frequencies were 1.00 (reference) for less than 1 cup/d, 0.93 (95% confidence interval [CI], 0.83-1.05) for 1 to 2 cups/d, 0.95 (95% CI, 0.85-1.06) for 3 to 4 cups/d, and 0.88 (95% CI, 0.79-0.98) for 5 or more cups/d, respectively (P = .03 for trend). The corresponding data for women were 1.00, 0.98 (95% CI, 0.84-1.15), 0.82 (95% CI, 0.70-0.95), and 0.77 (95% CI, 0.67-0.89), respectively (P &lt; .001 for trend). The inverse association with cardiovascular disease mortality was stronger than that with all-cause mortality. This inverse association was also stronger in women (P = .08 for interaction with sex). In women, the multivariate hazard ratios of cardiovascular disease mortality across increasing green tea consumption categories were 1.00, 0.84 (95% CI, 0.63-1.12), 0.69 (95% CI, 0.52-0.93), and 0.69 ( 95% CI, 0.53-0.90), respectively (P = .004 for trend). Among the types of cardiovascular disease mortality, the strongest inverse association was observed for stroke mortality. In contrast, the hazard ratios of cancer mortality were not significantly different from 1.00 in all green tea categories compared with the lowest-consumption category. Conclusion Green tea consumption is associated with reduced mortality due to all causes and due to cardiovascular disease but not with reduced mortality due to cancer.

  334. No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study 査読有り

    N. Kikuchi, K. Ohmori, T. Shimazu, N. Nakaya, S. Kuriyama, Y. Nishino, Y. Tsubono, I. Tsuji

    BRITISH JOURNAL OF CANCER 95 (3) 371-373 2006年8月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6603230  

    ISSN:0007-0920

    詳細を見る 詳細を閉じる

    In a prospective study of 19 561 Japanese men, green-tea intake was not associated with a lower risk of prostate cancer (110 cases), the multivariate hazard ratio for men drinking &gt;= 5 cups compared with &lt; 1 cup per day being 0.85 (95% confidence interval 0.50-1.43, trend P=0.81).

  335. Personality traits and cancer survival: a Danish cohort study 査読有り

    N. Nakaya, P. E. Hansen, I. R. Schapiro, L. F. Eplov, K. Saito-Nakaya, Y. Uchitomi, C. Johansen

    BRITISH JOURNAL OF CANCER 95 (2) 146-152 2006年7月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6603244  

    ISSN:0007-0920

    詳細を見る 詳細を閉じる

    We conducted a population-based prospective cohort study in Denmark to investigate associations between the personality traits and cancer survival. Between 1976 and 1977, 1020 residents of the Copenhagen County completed a questionnaire eliciting information on personality traits and various health habits. The personality traits extraversion and neuroticism were measured using the short form of the Eysenck Personality Inventory. Follow- up in the Danish Cancer Registry for 1976 - 2002 revealed 189 incidents of primary cancer and follow-up for death from the date of the cancer diagnosis until 2005 revealed 82 deaths from all- cause in this group. A Cox proportional- hazards model was used to estimate the hazard ratios ( HRs) of death from all- cause according to extraversion and neuroticism adjusting for potential confounding factors. A significant association was found between neuroticism and risk of death ( HR, 2.3 ( 95% CI = 1.1 - 4.7); Linear trend P 0.04) but not between extraversion and risk of death ( HR, 0.9 ( 0.4 - 1.7); Linear trend P = 0.34). Similar results were found when using cancer- related death. Stratification by gender revealed a strong positive association between neuroticism and the risk of death among women ( Linear trend P = 0.03). This study showed that neuroticism is positively associated with cancer survival. Further research on neuroticism and cancer survival is needed.

  336. Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products 査読有り

    Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Kaori Ohmori-Matsuda, Taichi Shimazu, Naoki Nakaya, Kazuki Fujita, Ichiro Tsuji, Ryoichi Nagatomi

    AMERICAN JOURNAL OF CLINICAL NUTRITION 84 (1) 223-229 2006年7月

    出版者・発行元:AMER SOC CLINICAL NUTRITION

    DOI: 10.1093/ajcn/84.1.223  

    ISSN:0002-9165

    詳細を見る 詳細を閉じる

    Background: Several studies have reported that the intake of n-3 polyunsaturated fatty acids (PUFAs) or fish is inversely associated with serum C-reactive protein (CRP) concentrations, but few studies have evaluated the relations between serum CRP concentrations and consumption of n-3 PUFAs derived from marine products in populations with a diet rich in marine products. Therefore, it is still unclear whether a greater consumption of n-3 PUFAs is associated with lower serum CRP concentrations. Objective: The aim of this study was to investigate the relations between n-3 PUFA intake and serum CRP concentration in the Japanese, who have a diet rich in marine products. Design: We designed a cross-sectional survey of 401 men and 570 women aged &gt;= 70 y who were living in Japan. CRP concentrations were measured. and subjects whose serum CRP concentrations were &gt;= 10.0 mg/L were excluded. Dietary intake was assessed with a self-administered diet-history questionnaire. Results: After adjustment for several predictors of inflammation the odds ratio of high CRP ( &gt;= 1.0 mg/L) for increasing quartiles of total n-3 PUFA and cicosapentaenoic acid + docosahexaenoic acid were 1.0. 0.72, 0.57, and 0.44 (P for trend = 0.01) and 1.0, 0.91, 0.76, and 0.54 (P for trend = 0.03), respectively. Conclusions: Greater intake of n-3 PUFAs derived from marine products. as measured with a self-administered questionnaire, was independently related to a lower prevalence of high CRP concentrations in this older Japanese population with a diet rich in marine products. Our findings suggest that even very high intakes of n-3 PUFAs may lower serum CRP concentrations.

  337. Meat consumption and risk of colorectal cancer in Japan: The Miyagi cohort study 査読有り

    Y Sato, N Nakaya, S Kuriyama, Y Nishino, Y Tsubono, Tsuji, I

    EUROPEAN JOURNAL OF CANCER PREVENTION 15 (3) 211-218 2006年6月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/01.cej.0000197455.87356.05  

    ISSN:0959-8278

    詳細を見る 詳細を閉じる

    The association between meat consumption and risk of colorectal cancer has been controversial. We examined this question in a large prospective cohort study in Japan. From June through August 1990, 47 605 residents, aged 40-64 years, of Miyagi Prefecture in northern Japan completed a self-administered questionnaire, including a food frequency questionnaire. In the study population, we observed 474 incident cases of colorectal cancer during 11 years of follow-up, to March 2001. We used the Cox proportional hazards model to estimate the relative risk of colorectal cancer (colorectum, colon, rectum and proximal colon and distal colon) according to each of the categories of meat intake (total meat, beef, pork, ham or sausage, chicken and liver), with adjustment for sex, age and other potentially confounding variables. The multivariate relative risk of colorectal cancer in the highest category of total meat consumption compared with the lowest was 1.14 [95% confidence interval (Cl) = 0.85-1.53; P-trend=0.22]. We also found no significant association between total meat consumption and the risk of sub-site of colorectal cancer. In conclusion, our data do not support the hypothesis that meat consumption is a risk factor for colorectal cancer. European Journal of Cancer Prevention 15:211-218 (c) 2006 Lippincott Williams & Wilkins.

  338. The lung cancer database project at the National Cancer Center, Japan: Study design, corresponding rate and profiles of cohort 査読有り

    N Nakaya, K Goto, K Saito-Nakaya, M Inagaki, T Otani, T Akechi, K Nagai, F Hojo, Y Uchitomi, S Tsugane, Y Nishiwaki

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY 36 (5) 280-284 2006年5月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/jjco/hyl015  

    ISSN:0368-2811

    eISSN:1465-3621

    詳細を見る 詳細を閉じる

    Background: The lung cancer database project was established in 1999 at the National Cancer Center Hospital East, Japan, as an ongoing project to integrate data on various factors in lung cancer patients. The aim of the project was to construct a large-scale cancer registry for lung cancer that would contribute to basic research and clinical research in the future. Methods: Between July 1999 and July 2004, consecutive lung cancer patients were recruited into this project. The baseline survey consisted of self-administered questionnaires concerning various demographic data, health habits and psychological factors. Medical information was obtained from the patients' medical charts. Urine specimens and blood samples were collected, and DNA was extracted from blood lymphocytes. Results: Out of the 2506 patients who were asked to participate in the project, 2036 (81%) patients with newly diagnosed, untreated primary lung cancer were enrolled. The final analytic cohort consisted of 1995 patients. Virtually all of the 1995 patients (corresponding rate, 99%) completed the questionnaires on demographic data and health habits. The corresponding rates for the questionnaires on psychological factors and dietary habits were 99 and 94%, respectively. In a follow-up survey conducted to determine vital status as of December 2004, a total of 1051 patients (53%) had died and 44 patients (2%) were lost to follow-up. Conclusions: This paper overviews the rationale for initiating the lung cancer database project, Japan. This database should prove useful for researchers examining the pathogenesis of lung cancer and may contribute to the formulation of a framework for cancer treatment.

  339. Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis 査読有り

    E Yoshikawa, Y Matsuoka, H Yamasue, M Inagaki, T Nakano, T Akechi, M Kobayakawa, M Fujimori, N Nakaya, N Akizuki, S Imoto, K Murakami, K Kasai, Y Uchitomi

    BIOLOGICAL PSYCHIATRY 59 (8) 707-712 2006年4月

    出版者・発行元:ELSEVIER SCIENCE INC

    DOI: 10.1016/j.biopsych.2005.08.018  

    ISSN:0006-3223

    詳細を見る 詳細を閉じる

    Background: Major and minor depressive episodes in cancer patients are frequent and are frequently seen as the first depressive episode in a patient's life. However, the neurological basis of these depressive episodes remains largely unknown. Methods: Subjects were 51 breast cancer survivors (BCS) who has no history of any depressive episode before the cancer diagnosis (11 BCS with a history of a first minor depressive episode after cancer diagnosis, 11 BCS with a history of a first major depressive episode after cancer diagnosis, and 29 BCS with no history of any depressive episode after cancer diagnosis). We analyzed the prefrontal cortex (PFC) and amygdala volumes in a 1.5-Tesla Magnetic Resonance Imaging scanner. We characterized the structural correlates of depression using two conmplementary approaches. The first was voxel-based morphometry (VBM) that allowed us to scan the entire brain for reactive gray matter deficit. The second was classsical volumetry focussing on amygdala. Results: Voxel-based morphometry revealed no brain region, including PFC, for which volume was significantly different among the three groups. There wee trend-level differences in the left amygdala volume in the manual tracing method among the three groups. The left amygdala volumes in the subjects with a first minor and /or major depressive episode were significantly smaller than in those with no history of any depressive episode. Conclusion: It might be suggested that amygdala volume was associated with first minor and/or major depressive episode after cancer diagnosis.

  340. Depression and survival in patients with non-small cell lung cancer after curative resection: a preliminary study 査読有り

    N Nakaya, K Saito-Nakaya, N Akizuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Nagai, Y Nishiwaki, S Fukudo, Y Tsubono, Y Uchitomi

    CANCER SCIENCE 97 (3) 199-205 2006年3月

    出版者・発行元:WILEY-BLACKWELL

    DOI: 10.1111/j.1349-7006.2006.00160.x  

    ISSN:1347-9032

    eISSN:1349-7006

    詳細を見る 詳細を閉じる

    Psychological depression is thought to be a predictor of poor survival among cancer patients. The objective of the present study was to investigate the association between depression and survival in surgically treated Japanese patients with non-small cell lung cancer (NSCLC). From June 1996 through April 1999, a total of 229 patients with postoperative lung cancer were enrolled. Three months after the patients' surgery, the Structured Clinical Interview for DSM-III-R (SCID) and the Profile of Mood States (POMS) were used to assess the patient for depression, based on the interviewers' rating and a self-report, respectively. The follow-up period consisted of a total of 14 342 person-months (median = 69 months). As of January 2004, 55 deaths had occurred within the follow-up period. A Cox regression was used to estimate the hazard ratio (HR) of mortality adjusting for age, sex, smoking status, occasion of diagnosis, pathological stage and preoperative percentage forced expiratory volume in 1 s. The depression-dejection subscale on the POMS was divided into three score levels. The multivariate HR of survival for individuals with depression, as diagnosed by the SCID, was 2.2 (95% confidence interval 0.8-6.0) (P-value = 0.14), compared with individuals without depression. The multivariate HR of survival for subjects in the highest level of the POMS Depression-Dejection subscale was 1.4 (0.7-2.6), compared with in the lowest level (trend P-value = 0.0502). This prospective cohort study in Japan does not support the hypothesis that depression is associated with survival among NSCLC patients after curative resection, but further analysis involving a long-term follow-up period is needed.

  341. Marital status, social support and survival after curative resection in non-small-cell lung cancer 査読有り

    K Saito-Nakaya, N Nakaya, M Fujimori, N Akizuki, E Yoshikawa, M Kobayakawa, K Nagai, Y Nishiwaki, Y Tsubono, Y Uchitomi

    CANCER SCIENCE 97 (3) 206-213 2006年3月

    出版者・発行元:WILEY-BLACKWELL

    DOI: 10.1111/j.1349-7006.2006.00159.x  

    ISSN:1347-9032

    eISSN:1349-7006

    詳細を見る 詳細を閉じる

    It has been suggested that marital status and social support are associated with survival in cases of lung cancer, and that such an association may be mediated by several factors. In this prospective cohort study, we investigated the effect of marital status and social support on survival after curative resection for non-small cell lung carcinoma (NSCLC) in Japan. From June 1996 to April 1999, a total of 238 patients with resectable NSCLC were enrolled. Marital status and social support were assessed. The presence and absence of confidants and the satisfaction level with the confidants were used as factors reflecting social support. During the follow-up period, 57 deaths from all causes were identified through January 2004. For the statistical analysis, Cox proportional hazards regression analyses were used. With regard to marital status, the multivariable adjusted hazard ratio (HR) of unmarried patients versus married patients was 0.8 (95% confidence interval, 0.3-1.8) (P-value = 0.53) after controlling for potential confounding factors, including age, sex, occasion of cancer diagnosis, pathological stage, smoking status, smoking status after surgery and serum albumin level. Similarly, the multivariable adjusted HR of patients without confidants versus those with confidants was 1.0 (0.5-2.2) (P-value = 0.90), whereas the multivariable adjusted HR of the dissatisfied-with-confidants group versus the satisfied-with-confidants group was 0.7 (0.4-1.3) (P-value = 0.28). The present data do not support the hypothesis that marital status and social support are associated with survival in NSCLC.

  342. Dietary intakes and plasma 8-iso-prostaglandin F-2 alpha concentrations in community-dwelling elderly Japanese: The Tsurugaya Project 査読有り

    Shinichi Kuriyama, Satoru Ebihara, Atsushi Hozawa, Kaori Ohmori, Kayoko Kurashima, Naoki Nakaya, Toshifumi Matsui, Hiroyuki Arai, Yoshitaka Tsubono, Hidetada Sasaki, Ichiro Tsuji

    INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 76 (2) 87-94 2006年3月

    出版者・発行元:VERLAG HANS HUBER

    DOI: 10.1024/0300-9831.76.2.87  

    ISSN:0300-9831

    詳細を見る 詳細を閉じる

    We examined the association between dietary intakes and oxidative stress status in elderly Japanese. We analyzed cross-sectional data from a community-based Comprehension Geriatric Assessment conducted in 2002. The subjects included 961 Japanese subjects aged 70 years or older who were non-daily antioxidant supplements users. We measured plasma total 8-iso-prostaglandin (PG)F-2 alpha concentrations, a measurable lipid per-oxidation biomarker, using a specific enzyme immunoassay kit. Dietary intakes were assessed through a food frequency questionnaire. Subjects were divided into three groups according to their dietary intake frequencies. Logistic regression was applied to calculate the odds ratios (ORs) for being in the highest tertile of plasma 8-iso-PGF(2 alpha) concentration. Frequent intake of orange or other citrus fruits, or persimmon, strawberry, or kiwi-fruit was associated with lower plasma 8-iso-PGF(2 alpha) concentrations, respectively. After adjustment adjustment for potential confounders, the ORs and 95% confidence intervals (CIs) for orange or other citrus fruits were 1.00 (reference), 0.66 (0.47, 0.92), and 0.58 (0.39, 0.87) (p for trend, 0.009). Intake of persimmon, strawberry, or kiwi-fruit showed similar results. These associations were partly explained by vitamin C intake. Other dietary intake. Other dietary intakes had no association. Intake of fruits may have a beneficial effect against oxidative stress in elderly Japanese.

  343. No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors 査読有り

    E Yoshikawa, Y Matsuoka, M Inagaki, T Nakano, T Akechi, M Kobayakawa, M Fujimori, N Nakaya, N Akizuki, S Imoto, K Murakami, Y Uchitomi

    BREAST CANCER RESEARCH AND TREATMENT 92 (1) 81-84 2005年7月

    出版者・発行元:SPRINGER

    DOI: 10.1007/s10549-005-1412-6  

    ISSN:0167-6806

    詳細を見る 詳細を閉じる

    We investigated the adverse effects of adjuvant chemotherapy on the hippocampus in Japanese breast cancer survivors with (n=44) and without (n=31) adjuvant chemotherapy. There were no significant differences in hippocampal volume (magnetic resonance imaging) or additionally in memory function (Wechsler Memory Scale-Revised) between the two groups.

  344. Green tea and the risk of colorectal cancer: Pooled analysis of two prospective studies in Japan 査読有り

    Y Suzuki, Y Tsubono, N Nakaya, Y Koizumi, Y Suzuki, D Shibuya, Tsuji, I

    JOURNAL OF EPIDEMIOLOGY 15 (4) 118-124 2005年7月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.15.118  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    Background: Although laboratory experiments suggest protective effects of green tea against colorectal cancer, few prospective cohort studies have been conducted. Methods: We conducted a pooled analysis of two prospective cohort studies among residents in Miyagi Prefecture in rural northern Japan. The first study started in 1984 and included 26,311 subjects. The second study started in 1990 and included 39,604 subjects. The subjects responded to a self-administered questionnaire including an item on green tea consumption. With 7 to 9 years of follow-up, 305 colon and 211 rectal cancers were identified in the two cohorts through record linkage to a regional cancer registry. We used Cox regression to estimate the hazard ratio (HR) of colorectal cancer according to the consumption of green tea with adjustment for potential confounders, and pooled the estimates obtained from each cohort by general variance-based method. Results: Multivariate pooled HRs for colon cancer associated with drinking 1-2, 3-4, and 5 or more cups of green tea per day, as compared with less than 1 cup per day, were 1.06 (95% confidence interval [CI]=0.74-1.52), 1.10 (0.78-1.55), 0.97 (0.70-1.35), respectively (trend p=0.81). Corresponding HRs for rectal cancer were 0.85 (95% CI=0.56-1.29), 0.70 (0.45-1.08), 0.85 (0.58-1.23), respectively (trend p=0.31). Conclusions: Consumption of green tea was not associated with lower risk of colorectal cancer.

  345. Personality and cancer survival: the Miyagi cohort study 査読有り

    N Nakaya, Y Tsubono, Y Nishino, T Hosokawa, S Fukudo, D Shibuya, N Akizuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Saito-Nakaya, Y Uchitomi, Tsuji, I

    BRITISH JOURNAL OF CANCER 92 (11) 2089-2094 2005年6月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6602610  

    ISSN:0007-0920

    詳細を見る 詳細を閉じる

    We tested the hypothesis that personality plays a role in cancer outcome in a population-based prospective cohort study in Japan. In July 1990, 41 442 residents of Japan completed a short form of the Eysenck Personality Questionnaire-Revised and a questionnaire on various health habits, and between January 1993 and December 1997, 890 incident cases of cancer were identified among them. These 890 cases were followed up until March 2001, and a total of 356 deaths from all causes was identified among them. Cox proportional-hazards regression was used to estimate the hazard ratio (HR) of death according to four score levels on each of four personality subscales ( extraversion, neuroticism, psychoticism, and lie), with adjustment for potential confounding factors. Multivariable HRs of deaths from all causes for individuals in the highest score level on each personality subscale compared with those at the lowest level were 1.0 for extraversion ( 95% CI = 0.8 - 1.4; Trend P = 0.73), 1.1 for neuroticism ( 0.8 - 1.6; Trend P = 0.24), 1.2 for psychoticism ( 0.9 - 1.6; Trend P = 0.29), and 1.0 for lie ( 0.7 - 1.5; Trend P = 0.90). The data obtained in this population-based prospective cohort study in Japan do not support the hypothesis that personality is associated with cancer survival.

  346. Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study 査読有り

    Y Sato, Y Tsubono, N Nakaya, K Ogawa, K Kurashima, S Kuriyama, A Hozawa, Y Nishino, D Shibuya, Tsuji, I

    PUBLIC HEALTH NUTRITION 8 (3) 309-314 2005年5月

    出版者・発行元:CABI PUBLISHING

    DOI: 10.1079/PHN2004681  

    ISSN:1368-9800

    詳細を見る 詳細を閉じる

    Objective: Adequate fruit and vegetable intake has been suggested to protect against colorectal cancer. However, several recent prospective studies have reported no association. We therefore examined the association between fruit and vegetable intakes and the risk of colorectal cancer in a prospective cohort study in Japan. Design: Between June and August 1990, 47 605 Japanese men and women completed a self-administered questionnaire, including a food-frequency questionnaire. We divided the subjects into quartiles based on their self-reported fruit and vegetable consumption. There were 165 colon cancer and 110 rectal cancer incidences identified during 7 years of follow-up, to the end of December 1997. We used Cox proportional hazards models to estimate the relative risk (RR) of developing colorectal cancer according to the level of fruit and vegetable consumption, applying adjustments for potential confounders. Results: No statistically significant association was observed between fruit and vegetable consumption and the risk of colorectal cancer. The multivariate RR of colon cancer in the highest quartile of fruit and vegetable intake compared with the lowest was 1.13 ( 95% confidence interval (CI) 0.73-1.75), the RR for vegetables alone was 1.24 (95% CI 0.79-1.95) and that for fruit alone was 1.45 ( 95% CI 0.85-2.47). The corresponding multivariate RRs for rectal cancer were 1.12 ( 95% CI 0.67-1.89), 1.14 ( 95% CI 0.67-1.93) and 1.41 ( 95% CI 0.73-2.73). Conclusions: We found no association between the consumption of fruit and vegetables and the risk of colorectal cancer among the Japanese population.

  347. Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study 査読有り

    N Nakaya, Y Tsubono, S Kuriyama, A Hozawa, T Shimazu, K Kurashima, S Fukudo, D Shibuya, Tsuji, I

    EUROPEAN JOURNAL OF CANCER PREVENTION 14 (2) 169-174 2005年4月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/00008469-200504000-00013  

    ISSN:0959-8278

    詳細を見る 詳細を閉じる

    The objective of this study was to investigate the association between alcohol consumption and the risk of total cancer, and to estimate the proportion of total cancer attributable to drinking habit in Japanese men. From June through August 1990, a total of 21201 Japanese men completed a self-administered questionnaire on various health habits, including alcohol consumption. During 153 389 person-years of follow-up through December 1997, we identified a total of 882 cases of cancer. We used Cox proportional hazards regression to estimate the relative risk of total cancer according to categories of alcohol consumption. The risk for total cancer was significantly higher in ex-drinkers than never-drinkers. There was a dose-response relationship between the amount of alcohol consumed and the risk of total cancer among current drinkers: multivariate RRs in reference to never-drinkers (95% confidence intervals (Cl)) were 1.1 (0.8-1.3), 1.3 (1.0-1.7), and 1.3 (1.1-1.7) in current drinkers who consumed less than 22.8 g, 22.8-45.5 g, 45.6 g or more alcohol per day, respectively (P for trend &lt; 0.001). Estimated 17.9% (95% Cl 3.1-30.5) of total cancer risk was attributable to drinking habit. In our findings, approximately 20% of the total cancer cases in Japanese men may be prevented by alcohol control. (c) 2005 Lippincott Williams & Wilkins.

  348. Personality and mortality from ischemic heart disease and stroke 査読有り

    N Nakaya, Y Tsubono, T Hosokawa, A Hozawa, S Kuriyama, S Fukudo, Tsuji, I

    CLINICAL AND EXPERIMENTAL HYPERTENSION 27 (2-3) 297-305 2005年2月

    出版者・発行元:TAYLOR & FRANCIS INC

    DOI: 10.1081/CEH-200048930  

    ISSN:1064-1963

    詳細を見る 詳細を閉じる

    Background. The role of personality in the causation of circulatory diseases has been controversial. Methods. From June through August 1990, 41,442 residents of Miyagi Prefecture in northern Japan completed the Japanese version of the short-form Eysenck Personality Questionnaire-Revised and another questionnaire on various health habits. During 11 years of follow-up until March 31 2001, we identified 90 deaths from ischemic heart disease (IHD) and 131 deaths from stroke. We used Cox regression to estimate the relative risk of IHD and stroke according to the three levels of four personality subscales (extraversion, neuroticism, psychoticism, and lie), with adjustment for sex, age, and other potentially confounding variables. Results. Multivariate relative risks of IHD for the highest verses the lowest level of personality subscales were 0.7 for extraversion, 1.1 for neuroticism, 1.3 for psychoticism, and 0.8 for lie. Multivariate relative risks of stroke for the highest verses the lowest level of personality subscales were 1.0 for extraversion, 0.9 for neuroticism, 1.2 for psychoticism, and 1.2 for lie. Conclusions. This prospective study does not support the hypothesis that personality is a risk factor for mortality from IHD and stroke.

  349. Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival 査読有り

    N Nakaya, S Fukudo, N Akizuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Shimizu, K Nagai, Y Nishiwaki, Y Uchitomi

    ACTA ONCOLOGICA 44 (4) 399-405 2005年

    出版者・発行元:TAYLOR & FRANCIS LTD

    DOI: 10.1080/02841860510029635  

    ISSN:0284-186X

    eISSN:1651-226X

    詳細を見る 詳細を閉じる

    Cortisol has been speculated to play a role in survival from cancer. The objective of this study was to investigate the association between 24-h urinary cortisol levels and survival from non-small cell lung cancer. From June 1996 to April 1999, a total of 226 patients with resectable non-small cell lung cancer were enrolled. Urine samples were collected over a 24-h period before the curative resections. A total of 14 650 person-months (median =71 months, range =1 -97 months) were accrued. Over the follow-up period, 56 deaths from all causes were identified through January 2004. Cox proportional hazards regression analyses were used to estimate the relative risk (RR) of death from all causes according to three categories of 24-h urinary cortisol levels. Multivariable RRs of death from all causes for individuals in the highest and intermediate categories, compared with the lowest category, were 1.09 (95% confidence interval 0.54-2.21) and 1.17 (0.55-2.46), respectively (p for trend = 0.17). The present data do not support the hypothesis that 24-h urinary cortisol levels are associated with survival from non-small cell lung cancer.

  350. Cigarette smoking and the risk of gastric cancer: A pooled analysis of two prospective studies in Japan 査読有り

    Y Koizumi, Y Tsubono, N Nakaya, S Kuriyama, D Shibuya, H Matsuoka, Tsuji, I

    INTERNATIONAL JOURNAL OF CANCER 112 (6) 1049-1055 2004年12月

    出版者・発行元:WILEY-LISS

    DOI: 10.1002/ijc.20518  

    ISSN:0020-7136

    詳細を見る 詳細を閉じる

    To examine the association between cigarette smoking and the risk of gastric cancer, we conducted a pooled analysis of 2 population-based prospective cohort studies in rural northern Japan. Cohort 1 included 9,980 men (greater than or equal to40 years old) and Cohort 2 included 19,412 men (40-64 years old). The subjects completed a self-administered questionnaire on cigarette smoking and other health habits. We identified 228 cases of gastric cancer among Cohort 1 subjects (9 years of follow-up with 74,073 person-years) and 223 among Cohort 2 subjects (7 years of follow-up with 141,675 person-years). From each cohort, we computed the relative risk (RR) and 95% confidence interval (CI) of gastric cancer associated with smoking using a Cox regression analysis and pooled these estimates to obtain summary measures. The pooled multivariate RRs (95% CIs) for current smokers and past smokers compared to subjects who had never smoked were 1.84 (1.39-2.43) and 1.77 (1.29-2.43), respectively. The higher number of cigarettes smoked per day among current smokers was associated with a linear increase in risk (trend p &lt; 0.05). The significant increase in risk for past smokers remained for up to 14 years after cessation. An increased risk was noted for cancer of the antrum but not for cardia or body lesions. The risk was increased for both differentiated and nondifferentiated histologic subtypes. Our findings support the hypothesis that cigarette smoking is a risk factor for gastric cancer. (C) 2004 Wiley-Liss, Inc.

  351. Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study 査読有り

    T Watanabe, N Nakaya, K Kurashima, S Kuriyama, Y Tsubono, Tsuji, I

    EUROPEAN JOURNAL OF CANCER 40 (14) 2109-2115 2004年9月

    出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD

    DOI: 10.1016/j.ejca.2004.06.014  

    ISSN:0959-8049

    詳細を見る 詳細を閉じる

    The objective of this study was to investigate the association between constipation or laxative use and the risk of colorectal cancer in Japanese men and women. In 1990, we delivered a self-administered questionnaire to 41670 subjects who were 40-64 years old. During the seven years of follow-up, 251 incident cases of colorectal cancer were documented. Constipation was defined as a bowel movement frequency of less than daily. The multivariate relative risk (RR) of colorectal cancer for constipated subjects compared with those with daily bowel movements was 1.35 (95% Confidence Interval: 0.99-1.84). The RR for laxative users over non-users was 1.31 (0.88-1.95), and for frequent users (twice a week or more) it was 2.75 (1.48-5.09). When colorectal cancers were divided into colon cancers or rectal cancers, a significant association was found with colon cancer alone. Our results support the hypothesis that constipation or laxative use increases the risk of colon cancer. (C) 2004 Elsevier Ltd. All rights reserved.

  352. [A survey regarding the implementation of cancer screening among municipalities in Japan]. 査読有り

    Nakaya N, Ohmori K, Suzuki Y, Hozawa A, Kuriyama S, Tsubono Y, Tsuji I

    [Nihon koshu eisei zasshi] Japanese journal of public health 51 530-539 2004年7月

    出版者・発行元:7

    DOI: 10.11236/jph.51.7_530  

    ISSN:0546-1766

  353. Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan 査読有り

    Y Suzuki, Y Tsubono, N Nakaya, Y Suzuki, Y Koizumi, Tsuji, I

    BRITISH JOURNAL OF CANCER 90 (7) 1361-1363 2004年4月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6601652  

    ISSN:0007-0920

    詳細を見る 詳細を閉じる

    In a pooled analysis of two prospective studies with 35 004 Japanese women, green-tea intake was not associated with a lower risk of breast cancer (222 cases), the multivariate relative risk for women drinking greater than or equal to 5 cups compared with &lt; 1 cup per day being 0.84 (95% confidence interval 0.57-1.24, Trend P = 0.69).

  354. Laterality and imbalance of muscle stiffness relate to personality 査読有り

    Naoki Nakaya, Hiroaki Kumano, Keiji Minoda, Motoyori Kanazawa, Shin Fukudo

    Behavioral Medicine 30 (1) 5-9 2004年3月

    出版者・発行元:1

    DOI: 10.3200/BMED.30.1.5-10  

    ISSN:0896-4289

    詳細を見る 詳細を閉じる

    The authors' purpose in this study was to test the hypothesis that laterality and imbalance of muscle stiffness relate to personality. The authors selected 23 healthy volunteers and divided them into two groups based on the predominance of muscle stiffness on the left or right side. Imbalance of muscle stiffness was calculated as the absolute value of the difference of muscle stiffness between the right and left sides. The authors evaluated personality with the Japanese version of the Eysenck Personality Questionnaire. Subjects with left predominant muscle stiffness of the rectal abdominis had significantly higher neuroticism score than those with right predominant muscle stiffness. Subjects with more imbalance of muscle stiffness in the latissimus dorsi and in the trapezius had significantly higher neuroticism and psychoticism scores than those with less imbalance. The findings suggest that laterality and imbalance of muscle stiffness relate to personality.

  355. Follow-up and mortality profiles in the Miyagi Cohort Study 査読有り

    Tsuji, I, Y Nishino, Y Tsubono, Y Suzuki, A Hozawa, N Nakaya, K Fujita, S Kuriyama, D Shibuya, A Fukao, S Hisamichi

    JOURNAL OF EPIDEMIOLOGY 14 S2-S6 2004年2月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.14.S2  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BACKGROUND: Findings from a large-scale population-based prospective cohort would lead us to better understanding of the relationship between lifestyle and health, thus better provision of strategies for disease prevention and health promotion. METHODS: We conducted a baseline survey with two self-administered questionnaires regarding lifestyle and personality on the residents aged 40 to 64 years in 14 municipalities of Miyagi Prefecture, Japan, during June through August, 1990. Out of the eligible 51,925 residents, 47,605 (91.7%) responded to the lifestyle questionnaire and formed the cohort under study. We then have been following up the subjects for mortality, migration, and incidence of cancer. RESULTS: During the follow-up from June 1990 through March 2001, 2,536 subjects (5.3%) died and 2,166 subjects (4.5%) emigrated. The distribution of the causes of death among the study subjects was quite consistent with the national average. CONCLUSIONS: In this cohort study, both the participation rate and the follow-up rate are satisfactorily high. We expect this Miyagi Cohort Study to provide the society with evidence for health promotion and disease prevention.

  356. Alcohol consumption and mortality in Japan: The Miyagi Cohort Study 査読有り

    N Nakaya, K Kurashima, J Yamaguchi, T Ohkubo, Y Nishino, Y Tsubono, D Shibuya, S Fukudo, A Fukao, Tsuji, I, S Hisamichi

    JOURNAL OF EPIDEMIOLOGY 14 S18-S25 2004年2月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.14.S18  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BACKGROUND: We examined the association between alcohol consumption and all-cause mortality in Japanese men and women. METHODS: From June through August 1990, a total of 39,076 subjects (20,660 men and 18,416 women) in 14 municipalities of Miyagi Prefecture in rural northern Japan (40-64 years of age) completed a self-administered questionnaire that included information about alcohol consumption and various health habits. During 11 years of follow-up, we identified 1,879 deaths (1,335 men and 544 women). We used Cox proportional-hazards regression to estimate relative risk (FIR) of all-cause mortality according to categories of alcohol consumption and to adjust for age, education, marital status, past histories of chronic diseases, body mass index, smoking, walking and dietary variables. RESULTS: Among men, the risk for all-cause mortality was significantly higher in past drinkers than never-drinkers (multivariate RR, 1.86; 95% confidence interval [CI], 1.50-2.29). There was a dose-response association between alcohol consumption and the risk of all-cause mortality among current drinking men: multivariate RRs in reference to never-drinkers (95% CI) were 1.10 (0.90-1.33), 1.17 (0.96-1.42), 1.16 (0.96-1.40), and 1.62 (1.32-1.99) in current drinkers who consumed less than 22.8 g, 22.8-45.5 g, 45.6-68.3 g, and 68.4 g or more alcohol per day, respectively (P for trend&lt;0.001). Similar association was observed among women (P for trend=0.005). CONCLUSIONS: The results indicated that alcohol consumption tended to be associated with linear increase in risk of all-cause mortality among Japanese men and women, and the association was remarkable for younger men.

  357. Body mass index and mortality in Japan: The Miyagi Cohort Study 査読有り

    S Kuriyama, K Ohmori, C Miura, Y Suzuki, N Nakaya, K Fujita, Y Sato, Y Tsubono, Tsuji, I, A Fukao, S Hisamichi

    JOURNAL OF EPIDEMIOLOGY 14 S33-S38 2004年2月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.14.S33  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BACKGROUND: The relation between body mass index (BMI) and mortality is not well established. The objective of this study was to examine the association in Japanese adults. METHODS: In 1990, 18,740 men and 20,870 women in Miyagi Prefecture in rural northern Japan (40-64 years of age) completed a self-administered questionnaire including height and weight. Cox regression was used to estimate relative risk (RR) of mortality according to levels of BMI, with adjustment for age, marital status, smoking, drinking, walking, and weight change since 20 years of age. RESULTS: During 11 years of follow-up, 1,121 men and 567 women had died. Compared with the referent BMI category (23.0-24.9), women in the highest BMI category (BMI&gt;30.0) had a RR of death of 1.64 (95% confidence interval (CI), 1.09-2.49) and men and women in the lowest BMI categories (BMI&lt;18.5) had a RR of death of 2.06 (95% Cl, 1.49-2.84) and 1.83 (95% Cl, 1.17-2.88), respectively, after adjustment for potential confounders and after exclusion of deaths occurring in the first three years of follow-up. We did not observe significant differences in mortality for subjects with wide range of BMI (18.5 or higher in men and 18.5 to 29.9 in women). CONCLUSIONS: The risk of death from all causes increases in lean men and women, and obese women in this cohort.

  358. Health practices and mortality in Japan: Combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study 査読有り

    Y Tsubono, Y Koizumi, N Nakaya, K Fujita, H Takahashi, A Hozawa, Y Suzuki, S Kuriyama, Tsuji, I, A Fukao, S Hisamichi

    JOURNAL OF EPIDEMIOLOGY 14 S39-S45 2004年2月

    出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC

    DOI: 10.2188/jea.14.S39  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BACKGROUND: Evidence is limited regarding the association between the combinations of multiple health practices and mortality. METHODS: In 1990, 28,333 men and women in Miyagi Prefecture in rural northern Japan (40-64 year of age) completed a self-administered questionnaire. A lifestyle score was calculated by adding the number of high-risk practices (smoking, consuming :22.8 g alcohol/d, walking &lt;1 hr/d, body mass index &lt;18.5 or 30.0). Cox regression was used to estimate relative risk (RR) of mortality according to the lifestyle score, with adjustment for age, education, marital status, past history of diseases, and dietary variables. During 11 years of follow-up, 1,200 subjects had died. RESULTS: We observed linear increase in risk of death associated with increasing number of high-risk practices: compared with men who had no high-risk practices, multivariate RRs for men who had 1 to 4 practices were 1.20, 1.66, 1.94, and 3.96, respectively (P for trend&lt;0.001), and corresponding RRs for women were 1.31, 2.14, 3.98, 5.56, respectively (P for trend&lt;0.001). A unit increase in the number of high-risk practices corresponded to being 2.8 and 4.8 years older for men and women, respectively. CONCLUSONS: In this prospective cohort study of middle-aged men and women in rural Japan, a larger number of high-risk practices was associated with linear increase in risk of all-cause mortality.

  359. パーソナリティーと虚血性心疾患および脳血管疾患に関する前向きコホート研究(第56回日本心身医学会東北地方会演題抄録)

    中谷 直樹, 坪野 吉孝, 細川 徹, 西野 善一, 渋谷 大助, 福土 審, 辻 一郎

    心身医学 44 (2) 156-156 2004年

    出版者・発行元:一般社団法人 日本心身医学会

    DOI: 10.15064/jjpm.44.2_156_1  

  360. 都市在住の高齢者におけるソーシャル・サポートと抑うつ症状の関連性 査読有り

    小泉 弥生, 荒井 啓行, 辻 一郎, 粟田 主一, 関 徹, 中谷 直樹, 栗山 進一, 鈴木 寿則, 大森 芳, 寳澤 篤, 海老原 覚

    日本老年医学会雑誌 41 (4) 426-433 2004年

    出版者・発行元:一般社団法人 日本老年医学会

    DOI: 10.3143/geriatrics.41.426  

    ISSN:0300-9173

    詳細を見る 詳細を閉じる

    都市在住の高齢者におけるソーシャル・サポートと抑うつ症状の関連を明らかにするため, 仙台市T地区の70歳以上住民に対し総合機能評価を平成14年7月から8月に行った. 対象2,730人のうち1,198人が参加し, 聞き取り調査を受けた. ソーシャル・サポートに関しては, 村岡ら (1996) の調査票により (i) 困ったときの相談相手, (ii) 体の具合の悪いときの相談相手, (iii) 家事などの日常生活を援助してくれる人, (iv) 具合の悪いとき病院に連れて行ってくれる人, (v) 寝込んだとき身の回りの世話をしてくれる人の有無を尋ねた. 抑うつ症状の評価は Geriatric Depression Scale (GDS) 30項目を用い, GDSに回答した1,170人のうち, Mini-Mental State Examination (MMSE) が18点以上で研究に同意した1,146人を解析対象とした. GDS 10点以下を非抑うつ群, 11点以上または抗うつ剤服用者を抑うつ群とした. ソーシャル・サポートの欠如と抑うつ症状の出現に関する多変量補正オッズ比 (95%信頼区間) を (i) から (v)の各項目について, 多重ロジスティック回帰分析により算出した. その際, 年齢, 配偶者の有無, 同居人数, 既往疾患数, 教育レベル, 認知機能, 運動能力, 痛み, 主観的健康度を補正した. 抑うつ群は男性134人 (27.9%), 女性259人 (38.9%) であった. 質問 (i) から (v) まで各々の「ある」者に比べて「ない」者では抑うつ症状出現のオッズ比 (95%信頼区間) は, 男性では (i) 2.5 (1.5~4.1), (ii) 1.9 (1.1~3.2), (iii) 2.7 (1.7~4.4), (iv) 1.9 (1.1~3.2), (v) 2.8 (1.6~4.9) と全項目で有意に上昇した. 女性では (i) 1.2 (0.8~1.8), (ii) 1.2 (0.8~1.8), (iii) 1.4 (1.0~2.0), (iv) 1.6 (1.1~2.3), (v) 2.0 (1.4~2.9) と (iii), (iv), (v) の項目で有意にオッズ比が上昇した. 都市部高齢者では男女ともソーシャル・サポートの欠如と抑うつ症状との間に有意な関連があった. しかも男性では, 関連するソーシャル・サポートの種類と関連の強さの両面において影響が顕著であった.

  361. Preliminary study: Psychological effects of muscle relaxation on juvenile delinquents 査読有り

    N Nakaya, H Kumano, K Minoda, T Koguchi, K Tanouchi, M Kanazawa, S Fukudo

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE 11 (3) 176-180 2004年

    出版者・発行元:LAWRENCE ERLBAUM ASSOC INC

    DOI: 10.1207/s15327558ijbm1103_6  

    ISSN:1070-5503

    詳細を見る 詳細を閉じる

    The purpose of this study is to test our hypothesis that muscle relaxation is effective on the psychological well-being of juvenile delinquents. Subjects were 16 juvenile delinquents who had entered a reform school. Subjects were divided into two groups. The muscle relaxation group received muscle relaxation therapy once a week for a total of 4 times. The control group spent an ordinary daily life in the reformatory. Psychological questionnaires used were the Rosenzweig Picture Frustration Study (P-F study), the Psychological Stress Response Scale (PSRS), and the Eysenck Personality Questionnaire (EPQ). There was a significant Group x Time interaction of the Group Conformity Rating (GCR) of the P-F study (F [1, 14] = 10.1, P = 0.007). There were no significant interactions in the other psychological subscales. Thus, muscle relaxation therapy may improve frustration tolerance among juvenile delinquents.

  362. Personality and the risk of cancer 査読有り

    N Nakaya, Y Tsubono, T Hosokawa, Y Nishino, T Ohkubo, A Hozawa, D Shibuya, S Fukudo, A Fukao, Tsuji, I, S Hisamichi

    JOURNAL OF THE NATIONAL CANCER INSTITUTE 95 (11) 799-805 2003年6月

    出版者・発行元:OXFORD UNIV PRESS INC

    ISSN:0027-8874

    詳細を見る 詳細を閉じる

    Background: The role of personality in the causation of cancer has been controversial. We examined this question in a large, prospective study. Methods: From June through August 1990, 30 277 residents of Miyagi Prefecture in northern Japan completed a Japanese version of the short form of the Eysenck Personality Questionnaire-Revised and a questionnaire on various health habits. There were 671 prevalent cases of cancer at baseline, and 986 incident cases of cancer were identified during 7 years of follow-up, through December 1997. We used Cox proportional hazards regression to estimate the relative risk (RR) of incident cancer (total, stomach, colorectal, breast, and lung) according to four levels of each of four personality subscales (extraversion, neuroticism, psychoticism, and lie), with adjustment for sex, age, education, smoking, alcohol use, body mass index, and family history of cancer. Statistical tests were two-sided. Results: Multivariable RRs of total cancer for individuals in the highest level of each personality subscale as compared with those in the lowest were 0.9 for extraversion (95% confidence interval [CI] = 0.7 to 1.1; P-trend = .32), 1.1 for psychoticism (95% CI = 0.9 to 1.3; P-trend = .96), 0.9 for lie (95% CI = 0.7 to 1.0; P-trend = .19), and 1.2 for neuroticism (95 % CI = 1.0 to 1.4; P-trend = .06). There were no associations between any personality subscale and risk of specific cancers. Neuroticism showed statistically significant positive, linear associations with prevalent cancer at baseline (p(trend) &lt; .001) and with the 320 incident cancer cases diagnosed within the first 3 years of follow-up (P-trend &lt; .03); however, it showed no association with the 666 cases diagnosed during the fourth through the seventh years of follow-up (P-trend &lt; .43). Conclusion: Our data do not support the hypothesis that personality is a risk factor for cancer incidence. The association between neuroticism and prevalent cancer may be a consequence, rather than a cause, of cancer diagnosis or symptoms.

  363. No association between green tea and the risk of gastric cancer: Pooled analysis of two prospective studies in Japan 査読有り

    Y Koizumi, Y Tsubono, N Nakaya, Y Nishino, D Shibuya, H Matsuoka, Tsuji, I

    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 12 (5) 472-473 2003年5月

    出版者・発行元:AMER ASSOC CANCER RESEARCH

    ISSN:1055-9965

  364. Increased risk of irritable bowel syndrome in depressive individuals in elderly population 査読有り

    N Nakaya, K Saito, K Kurashima, A Hozawa, M Kanazawa, S Fukudo, Tsuji, I

    GASTROENTEROLOGY 124 (4) A86-A86 2003年4月

    出版者・発行元:W B SAUNDERS CO

    ISSN:0016-5085

  365. 長期加療中脳卒中患者の心理的ストレス状況と筋弾性との関係

    濱口 豊太, 中谷 直樹, 奈良 進弘, 赤松 郁夫

    新潟医療福祉学会誌 3 (1) 77-82 2003年3月

    出版者・発行元:新潟医療福祉大学

    ISSN:1346-8774

    詳細を見る 詳細を閉じる

    不安と筋緊張が関連することはよく知られている。本研究は、長期加療中の脳卒中患者は、心理的ストレスが高く、かつ筋緊張が高いという仮説を症例対照研究にて検証した。対象は脳卒中患者10例、健常者19例。筋弾性計(PEK-1)を用い、対象者における左右の上腕二頭筋・上腕三頭筋・手指および手関節屈筋群・手指および手関節伸筋群・僧帽筋を測定した。心理的指標は、心理的ストレス反応尺度(PsychologicalStress Response Scale)を用いた。 本研究では、長期加療中の脳卒中患者において、心理的ストレス反応における抑うつと怒りのスコアが高値を示した。一方、脳卒中患者群の筋弾性値は健常者と差はなく、脳卒中患者における抑うつ気分が、心身相関により、筋緊張と関連することは見いだせなかった。長期加療中の脳卒中患者において、心理ストレス反応が高いことから、心理面への支援の重要性が示唆された。

  366. 都市に在住する70歳以上の高齢者のソーシャルサポートと抑うつ症状との関連性 (老年精神医学雑誌)

    小泉弥生, 粟田主一, 関徹, 松岡洋夫, 中谷直樹, 栗山進一, 大森芳, 寳澤篤, 辻一郎, 藤田和樹, 永富良一, 海老原覚, 荒井啓行

    老年精神医学雑誌 14 (5) 629-629 2003年

    出版者・発行元:(株)ワールドプランニング

    ISSN:0915-6305

  367. Validation of walking questionnaire for population-based prospective studies in Japan: Comparison with pedometer 査読有り

    Yoshitaka Tsubono, Ichiro Tsuji, Kazuki Fujita, Naoki Nakaya, Atsushi Hozawa, Takayoshi Ohkubo, Aya Kuwahara, Yoko Watanabe, Keiko Ogawa, Yoshikazu Nishino, Shigeru Hisamichi

    Journal of Epidemiology 12 (4) 305-309 2002年

    出版者・発行元:Japan Epidemiology Association

    DOI: 10.2188/jea.12.305  

    ISSN:1349-9092 0917-5040

    詳細を見る 詳細を閉じる

    PURPOSE: To assess the reproducibility and validity of a single-item, self-administered questionnaire on walking used in two population-based prospective cohort studies in northern Japan, using pedometer counts as the reference standard. METHODS: Fifty-one men and 55 women participating in the main cohort studies (mean age: 61.7 years) responded to a question on the average duration of walking per day five times at 3-month intervals. The subjects also provided 3 consecutive days of pedometer counts four times along with the first four questionnaire surveys. RESULTS: For the first and the fifth questionnaires administered one year apart, 55% of the subjects chose concordant categories among three options (=&lt 30 min / between 30 and 60 min / &gt = 60 min), and 13% chose the highest category in one questionnaire and the lowest in the other questionnaire. The sex- and age-adjusted mean daily numbers of walking steps counted by the pedometer were 5,857, 7,047, and 7,621 for the three categories of walking duration in the fifth questionnaire, and it showed significant linear associations with all of the five questionnaire measurements. CONCLUSON: The single-item questionnaire on walking is reasonably reproducible and valid, and useful in studying the health effects of walking among the Japanese population.

  368. 筋弾性とEMG及び心理的指標との関連

    濱口 豊太, 中谷 直樹

    国際医療福祉大学紀要 6 (0) 23-28 2001年12月22日

    出版者・発行元:国際医療福祉大学

    ISSN:1342-4661

    詳細を見る 詳細を閉じる

    本研究の目的は、リハビリテーションの臨床において簡便な筋緊張評価を可能にし、筋緊張と心理的指標との関連を検証することである。対象は健常者19名とし、筋緊張は左右の僧帽筋、上腕二頭筋、上腕三頭筋、手指および手関節伸筋群、手指および手関節屈筋群を測定した。心理指標はEysenck Personality Questionnaire-Revised (EPQ-R)、Psychological Strees Response Scale (PSRS)、ordinate scaleの3つの心理指標による評価を行った。筋弾性計による測定と積分筋電図との高い相関を示した(r=0.44-0.76)。筋弾性の左右差では、痛み(r=0.51,p&lt;0.05),不安感(r=0.48,p&lt;0.05)との有意な相関を示した。本研究は、リハビリテーションにおける筋緊張評価として、筋弾性計を用いることができる可能性を示した。また、筋緊張と心理・行動面が相関することが示唆された。

  369. 1.筋緊張と心理面との関連 : 左右差及び局所の状態の重要性(第50回 日本心身医学会東北地方会 プログラム・抄録集)

    中谷 直樹, 熊野 宏昭, 美野田 啓二, 福土 審

    心身医学 41 (6) 471-471 2001年

    出版者・発行元:一般社団法人 日本心身医学会

    DOI: 10.15064/jjpm.41.6_471_1  

  370. 14.筋骨格系の歪みとパーソナリティおよび心理的ストレス反応との関連の検討(第49回 日本心身医学会東北地方会 演題抄録)

    中谷 直樹, 熊野 宏昭, 美野田 啓二, 福土 審

    心身医学 41 (4) 300-300 2001年

    出版者・発行元:一般社団法人 日本心身医学会

    DOI: 10.15064/jjpm.41.4_300_3  

  371. 16.NIDDMの予後とセルフケア行動および心理社会的要因の影響の検討(第49回 日本心身医学会東北地方会 演題抄録)

    名倉 洋子, 熊野 宏昭, 中谷 直樹, 朝倉 徹, 檜尾 好徳, 及川 眞一, 豊田 隆謙, 松本 雅博, 相良 幹雄, 柿崎 正栄, 福土 審

    心身医学 41 (4) 301-301 2001年

    出版者・発行元:一般社団法人 日本心身医学会

    DOI: 10.15064/jjpm.41.4_301_1  

  372. 17.中学生の学校ストレス : 性差および学年差の検討(第48回日本心身医学会東北地方会 演題抄録)

    古口 高志, 中谷 直樹, 熊野 宏昭, 山内 祐一

    心身医学 40 (6) 492-493 2000年

    出版者・発行元:一般社団法人 日本心身医学会

    DOI: 10.15064/jjpm.40.6_492_4  

  373. IG-4 アローバランスグラフの信頼性の検討及び心理的質問表との関連性について(心理テストI)

    中谷 直樹, 熊野 宏昭, 美野田 啓二

    心身医学 39 95-95 1999年

    出版者・発行元:一般社団法人 日本心身医学会

    DOI: 10.15064/jjpm.39.supplementII_95_1  

  374. Partners’ ongoing treatment for chronic disease and the risk of psychological distress after the Great East Japan Earthquake. Nakaya N, Narita A, Tsuchiya N, Nakamura T, Tsuji I, Hozawa A, Tomita H. Tohoku Journal of Experimental Medicine (In press) 査読有り

︎全件表示 ︎最初の5件までを表示

MISC 267

  1. 東北メディカル・メガバンク計画三世代コホート調査の進捗と今後の計画

    石黒 真美, 小原 拓, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 目時 弘仁, 菊谷 昌浩, 菅原 準一, 中谷 直樹, 寳澤 篤, 栗山 進一

    Journal of Epidemiology 33 (Suppl.1) 117-117 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  2. 大規模観察研究におけるランダム男女ペア間の循環代謝リスク因子の類似性の検討

    中谷 直樹, 中谷 久美, 土屋 菜歩, 曽根 稔雅, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 目時 弘仁, 小原 拓, 石黒 真美, 寳澤 篤, 栗山 進一

    Journal of Epidemiology 33 (Suppl.1) 173-173 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  3. 正常高値血圧、高値血圧における中心血圧、頸動脈内膜中膜厚と新規高血圧発症の関連

    時岡 紗由理, 中谷 直樹, 中谷 久美, 高瀬 雅仁, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 千葉 一平, 目時 弘仁, 村上 任尚, 佐藤 倫広, 小原 拓, 栗山 進一, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 44回 80-80 2022年10月

    出版者・発行元:(NPO)日本高血圧学会

  4. 年齢と骨梁面積率との関連 年齢階級別の検討 ToMMo地域住民コホート調査

    菅野 郁美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 中村 智洋, 小原 拓, 目時 弘仁, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 203-203 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  5. 心血管・代謝疾患リスク要因における配偶者同士の類似性 2ヵ国バイオバンク横断研究

    中谷 直樹, 土屋 菜歩, 成田 暁, 中村 智洋, 目時 弘仁, 小原 拓, 石黒 真美, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集 81回 204-204 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  6. 尿ナトリウム/カリウム比と脳性ナトリウム利尿ペプチド 大迫研究

    室谷 智子, 佐藤 倫広, 村上 任尚, 中山 晋吾, 廣瀬 卓男, 橋本 英明, 遠山 真弥, 高畠 恭介, 辰巳 友佳子, 井上 隆輔, 坪田 恵[宇津木], 小暮 真奈, 中谷 直樹, 浅山 敬, 野村 恭子, 菊谷 昌浩, 目時 弘仁, 今井 潤, 寳澤 篤, 大久保 孝義

    東北公衆衛生学会誌 (71) 29-30 2022年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  7. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌 (71) 28-28 2022年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  8. 統合失調症患者に対するがん検診勧奨法の質的評価 混合研究法を用いた無作為化比較試験の二次解析

    山田 裕士, 藤原 雅樹, 島津 太一, 江藤 剛, 児玉 匡史, 宋 龍平, 松下 貴紀, 吉村 優作, 堀井 茂男, 藤森 麻衣子, 高橋 宏和, 中谷 直樹, 宮路 天平, 樋之津 史郎, 原田 馨太, 岡田 裕之, 内富 庸介, 山田 了士, 稲垣 正俊

    精神神経学雑誌 124 (4付録) S-373 2022年4月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  9. 精神科臨床場面における多職種協働によるがん検診の受診勧奨法のランダム化比較試験

    藤原 雅樹, 山田 裕士, 島津 太一, 児玉 匡史, 宋 龍平, 松下 貴紀, 吉村 優作, 堀井 茂男, 藤森 麻衣子, 高橋 宏和, 中谷 直樹, 掛田 恭子, 宮路 天平, 樋之津 史郎, 原田 馨太, 岡田 裕之, 内富 庸介, 山田 了士, 稲垣 正俊

    精神神経学雑誌 124 (4付録) S-643 2022年4月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  10. 地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと 健診機関とのタイアップ

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 菅野 郁美, 板橋 芙美, 黒川 悦子, 大川 亜美, 宮川 健, 永吉 翔, 牛田 悠介, 清水 友紀子, 上田 宏幸, 土屋 菜歩, 中谷 直樹, 寳澤 篤

    総合健診 49 (1) 205-205 2022年1月

    出版者・発行元:(一社)日本総合健診医学会

    ISSN:1347-0086

    eISSN:1884-4103

  11. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 80回 219-219 2021年11月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  12. 統合失調症患者における日本語版WHODAS 2.0 12項目自己記入版の妥当性、信頼性の検討

    和田 里穂, 藤原 雅樹, 山田 裕士, 中谷 直樹, 藤森 麻衣子, 宋 龍平, 児玉 匡史, 樋口 裕二, 掛田 恭子, 内富 庸介, 山田 了士, 稲垣 正俊

    総合病院精神医学 33 (Suppl.) S-165 2021年11月

    出版者・発行元:(一社)日本総合病院精神医学会

    ISSN:0915-5872

  13. 特定健康診査時に尿ナトカリ計で4年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

    小暮 真奈, 須藤 庸子, 及川 満代, 土屋 菜歩, 平田 匠, 畑中 里衣子, 佐々木 久美子, 黒川 悦子, 宮川 健, 牛田 悠介, 上田 宏幸, 佐々木 秀美, 本間 洋子, 中谷 直樹, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 43回 261-261 2021年10月

    出版者・発行元:(NPO)日本高血圧学会

  14. 東日本大震災に伴う災害による健康影響に関する文献レビュー

    高瀬雅仁, 五十嵐有香, 中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 中村智洋, 後岡広太郎, 後岡広太郎, 寳澤篤

    日本循環器病予防学会誌 56 (3) 2021年

    ISSN:1346-6267

  15. 精神障害者のがん診療における課題の定量:がん医療従事者に対する質問紙調査

    山田裕士, 藤原雅樹, 江藤剛, 和田里穂, 井上真一郎, 児玉匡史, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 掛田恭子, 島津太一, 中谷直樹, 田村研治, 田端雅弘, 内富庸介, 山田了士, 稲垣正俊

    日本サイコオンコロジー学会総会プログラム・抄録集 34th (Web) 2021年

  16. 精神障害者に対するがん診療の課題:がん医療従事者と精神科医療従事者に対する質問紙調査の質的分析

    江藤剛, 藤原雅樹, 山田裕士, 和田里穂, 樋口裕二, 井上真一郎, 児玉匡史, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 掛田恭子, 島津太一, 中谷直樹, 田端雅弘, 内富庸介, 山田了士, 稲垣正俊

    日本サイコオンコロジー学会総会プログラム・抄録集 34th (Web) 2021年

  17. がん罹患者の配偶者の死亡リスク:大崎コホート2006

    中谷直樹, 中谷直樹, 曽根稔雅, 遠又靖丈, 遠又靖丈, 中谷久美, 中谷久美, 星真行, 清水研, 辻一郎, 辻一郎

    日本疫学会学術総会講演集(Web) 30th 2020年

  18. 「精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築」精神障害者のがん診断と治療における課題を明らかにし,問題を解決するための連携を促進する体制構築を目指す研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 井上真一郎, 和田里穂, 江藤剛

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 令和元年度 総括・分担研究報告書(Web) 2020年

  19. 「精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築」精神科臨床場面における多職種協働による効果的ながん検診の受診勧奨法の開発と効果を検証する研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 樋之津史郎, 藤原雅樹, 堀井茂男, 児玉匡史, 宮路天平, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 岡田裕之, 原田馨太, 黒崎美雪

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 令和元年度 総括・分担研究報告書(Web) 2020年

  20. 家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 223-223 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  21. 配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査

    中谷 直樹, 土屋 菜歩, 成田 暁, 石黒 真美, 目時 弘仁, 平田 匠, 小暮 真奈, 中村 智洋, 後岡 広太郎, 中谷 久美, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 224-224 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  22. 東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

    片柳 光昭, 富田 博秋, 瀬戸 萌, 根本 晴美, 奥山 純子, 鈴木 智美, 菅原 由美, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 小高 晃, 辻 一郎, 寳澤 篤

    精神神経学雑誌 115th (2019特別号) S753-S753 2019年6月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  23. 精神科病院に通院中の統合失調症患者の禁煙ステージとその後の禁煙行動 アンケートによる縦断調査

    藤原 雅樹, 樋口 裕二, 稲垣 正俊, 中谷 直樹, 藤森 麻衣子, 林原 千夏, 宋 龍平, 新川 郁太, 佐藤 康治郎, 矢田 勇慈, 児玉 匡史, 竹中 央, 来住 由樹, 掛田 恭子, 内富 庸介, 山田 了士

    精神神経学雑誌 (2019特別号) S436-S436 2019年6月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  24. 一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫, 宮崎 真理子, 寳澤 篤

    日本腎臓学会誌 61 (3) 332-332 2019年5月

    出版者・発行元:(一社)日本腎臓学会

    ISSN:0385-2385

  25. 東北メディカル・メガバンク計画 地域住民コホート 進捗と今後の展望

    寳澤 篤, 丹野 高三, 中谷 直樹, 平田 匠, 瀧 靖之, 栗山 進一, 菅原 準一, 坂田 清美, 辻 一郎, 呉 繁夫

    日本老年医学会雑誌 56 (Suppl.) 106-106 2019年5月

    出版者・発行元:(一社)日本老年医学会

    ISSN:0300-9173

  26. 尿ナトリウム/カリウム比を健診に追加することで高血圧のPAFが12%増加し約50%に:COI東北拠点と登米市の共同研究

    小暮真奈, 小暮真奈, 須藤庸子, 中村智洋, 中村智洋, 土屋菜歩, 土屋菜歩, 平田匠, 平田匠, 成田暁, 成田暁, 宮川健, 宮川健, 中谷直樹, 中谷直樹, 佐々木秀美, 寳澤篤, 寳澤篤

    日本循環器病予防学会誌 54 (2) 122 2019年4月11日

    ISSN:1346-6267

  27. 新規リスク因子(尿ナトカリ比高値・睡眠効率不良)の高血圧への集団寄与危険割合の検討

    平田 匠, 中村 智洋, 小暮 真奈, 宮川 健, 小原 拓, 中谷 直樹, 宇留野 晃, 菅原 準一, 栗山 進一, 寳澤 篤

    日本循環器病予防学会誌 54 (2) 121-121 2019年4月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  28. 非肥満者において肝機能指標の組み合わせと糖尿病の関連は飲酒により異なるか

    一迫 芙美, 平田 匠, 土屋 菜歩, 中村 智洋, 成田 暁, 小暮 真奈, 中谷 直樹, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本循環器病予防学会誌 54 (2) 115-115 2019年4月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  29. 東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

    平田 匠, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐藤 衛, 菊谷 昌浩, 石垣 泰, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫

    糖尿病 62 (Suppl.1) S-304 2019年4月

    出版者・発行元:(一社)日本糖尿病学会

    ISSN:0021-437X

  30. 東日本大震災による津波避難訓練の有効性

    中谷直樹, 根本晴美, YI Carine J, 佐藤文子, 新宮古都美, 庄子朋香, 佐藤翔輔, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 菅原由美, 兪志前, GUNAWANSA Nicole, 栗山進一, 村尾修, 佐藤健, 今村文彦, 富田博秋

    宮城県公衆衛生学会会誌 (51) 12 2019年3月

    ISSN:0912-747X

  31. 未治療高血圧者に対する平成29年度特定健康診査時の尿ナトカリ比及び保健指導後の医療受診動向について

    鈴木智美, 鈴木智美, 板橋由紀, 小暮真奈, 堀籠千賀, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 渡邊真孝, 小野誠司, 渡辺文昭, 寳澤篤

    宮城県公衆衛生学会会誌 (51) 13-13 2019年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  32. 東北メディカル・メガバンク機構 地域住民コホート調査詳細二次調査

    寳澤 篤, 中谷 直樹, 土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌 (51) 17-17 2019年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  33. 東日本大震災による家屋損壊程度と過敏性腸症候群の関連

    永家聖, 中谷直樹, 田中由佳里, 金澤素, 荻島創一, 高井貴子, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 栗山進一, 田中博, 辻一郎, 呉繁夫, 寳澤篤, 福土審

    日本疫学会学術総会講演集(Web) 29th 149 (WEB ONLY) 2019年1月30日

  34. 配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査

    中谷直樹, 土屋菜歩, 中谷久美, 成田暁, 平田匠, 中村智洋, 小暮真奈, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 122 (WEB ONLY) 2019年1月30日

  35. 非肥満者における肝機能指標の組み合わせと糖尿病の関連

    一迫芙美, 平田匠, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 中谷直樹, 栗山進一, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 151 (WEB ONLY) 2019年1月30日

  36. 夫婦間のメタボリック症候群及び構成因子の共有度:東北メディカル・メガバンク計画―地域住民コホート調査

    土屋菜歩, 橋本航, 中谷直樹, 中村智洋, 平田匠, 成田暁, 小暮真奈, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 154 (WEB ONLY) 2019年1月30日

  37. 遺伝因子と飲酒量の交互作用と随時血圧値の関連―東北メディカル・メガバンク計画地域住民コホート調査―

    成田暁, 中谷直樹, 小暮真奈, 田宮元, 中村智洋, 土屋菜歩, 平田匠, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 147 (WEB ONLY) 2019年1月30日

  38. 日本がん支持療法研究グループJapan Supportive,Palliative and Psychosocial Oncology Group(J-SUPPORT)の取り組みと実績:2016-2019

    華井明子, 全田貞幹, 松岡豊, 山口拓洋, 安部正和, 島津太一, 中谷直樹, 藤森麻衣子, 松本禎久, 宮路天平, 内富庸介

    日本がんサポーティブケア学会学術集会プログラム・抄録集 4th 2019年

  39. 精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 精神障害者のがん診断と治療における課題を明らかにし,問題を解決するための連携を促進する体制構築を目指す研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 井上真一郎

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 平成30年度 総括・分担研究報告書(Web) 2019年

  40. 精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 精神科臨床場面における多職種協働による効果的ながん検診の受診勧奨法の開発と効果を検証する研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 樋之津史郎, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 宮路天平, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 岡田裕之, 原田馨太

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 平成30年度 総括・分担研究報告書(Web) 2019年

  41. 東日本大震災の被災地住民における平均歩数の変化 地域住民コホート調査

    中谷 直樹, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 209-209 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  42. 尿中ナトリウムカリウム比値と家庭血圧値の変化 地域住民コホート調査

    小暮 真奈, 中谷 直樹, 土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 215-215 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  43. 東日本大震災の被災地住民における家庭血圧値の変化 地域住民コホート調査

    中村 智洋, 中谷 直樹, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 218-218 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  44. 東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 呉 繁夫, 大塚 耕太郎, 富田 博秋, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 252-252 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  45. 家屋損壊程度と骨梁面積率の変化量の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 平田 匠, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 253-253 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  46. 家屋の損壊の程度と頸動脈エコー内膜中膜肥厚の変化 地域住民コホート調査

    寳澤 篤, 中谷 久美, 平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 呉 繁夫

    日本公衆衛生学会総会抄録集 77回 345-345 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  47. 一般住民における尿Na/K比と腎機能障害への進行の関連 住民コホート調査

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 345-345 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  48. 東日本大震災に伴う家屋被害の程度とHbA1c値の変化の関連 地域住民コホート調査

    平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 358-358 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  49. 単日および複数日測定による尿ナトカリ比値と高血圧有病率との関連 東北メディカル・メガバンク計画コホート調査の成果から

    小暮 真奈, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 宮川 健, 栗山 進一, 菅原 準一, 菊谷 昌浩, 寳澤 篤

    日本循環器病予防学会誌 53 (2) 181-181 2018年5月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  50. 特定保健指導前後のナトリウムカリウム比変化と家庭血圧値変化との関連 東北大学COI拠点と七ヶ浜町の共同研究

    小暮 真奈, 宮川 健, 板橋 由紀, 鈴木 智美, 土屋 菜歩, 中村 智洋, 中谷 直樹, 青木 ゆかり, 阿部 真也, 安田 純, 寳澤 篤

    宮城県公衆衛生学会会誌 (50) 20-20 2018年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  51. サンプル間の非独立性が関連解析に及ぼす影響の予備的検討

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 田宮元, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 134 (WEB ONLY) 2018年2月1日

  52. 東日本大震災後の夫婦における生活習慣の共有度についての検討

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 77 (WEB ONLY) 2018年2月1日

  53. 日本茶摂取頻度と頸動脈内膜中膜肥厚の関連

    寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 木皿楓子, 丹野高三, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

    日本疫学会学術総会講演集(Web) 28th 116 (WEB ONLY) 2018年2月1日

  54. 東日本大震災の被災者における高い平均歩数と関連する要因:地域住民コホート調査

    中谷直樹, 成田暁, 土屋菜歩, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌弘, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 137 (WEB ONLY) 2018年2月1日

  55. 東日本大震災による家屋損壊の程度とメタボリック症候群の構成要素

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 137 (WEB ONLY) 2018年2月1日

  56. 統合失調症患者の住民がん検診受診率 市の検診受診記録を用いた単施設横断研究

    藤原 雅樹, 稲垣 正俊, 中谷 直樹, 樋口 裕二, 藤森 麻衣子, 林原 千夏, 宋 龍平, 掛田 恭子, 児玉 匡史, 内富 庸介, 山田 了士

    日本サイコオンコロジー学会総会・日本臨床死生学会総会合同大会プログラム・抄録集 30回・23回 218-218 2017年10月

    出版者・発行元:(一社)日本サイコオンコロジー学会・日本臨床死生学会

  57. 東日本大震災被災地における運動習慣の状況 TMM CommCohort Study

    高梨 信之, 丹野 高三, 佐々木 亮平, 坪田 恵, 坂田 清美, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 栗山 進一, 辻 一郎, 中村 元行, 人見 次郎

    日本公衆衛生学会総会抄録集 76回 603-603 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  58. 東日本大震災被災地における社会的孤立の状況 TMM CommCohort Study

    佐々木 亮平, 丹野 高三, 高梨 信之, 坪田 恵, 宇津木, 坂田 清美, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 栗山 進一, 辻 一郎, 中村 元行, 人見 次郎

    日本公衆衛生学会総会抄録集 76回 603-603 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  59. 東北メディカル・メガバンク計画地域住民コホート調査における参加者のAQについて

    山中 千鶴, 中谷 直樹, 成田 暁, 中村 智洋, 土屋 菜歩, 小暮 真奈, 菊谷 昌浩, 石黒 真美, 菅原 準一, 辻 一郎, 呉 繁夫, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集 76回 285-285 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  60. 東北メディカル・メガバンク計画における地域住民コホート調査の詳細二次調査の概要

    寳澤 篤, 丹野 高三, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 菊谷 昌浩, 目時 弘仁, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 中村 元行, 呉 繁夫

    日本公衆衛生学会総会抄録集 76回 287-287 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  61. 東日本大震災後の地域住民における腎機能と関連因子

    土屋 菜歩, 清元 秀泰, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 菊谷 昌浩, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 290-290 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  62. 尿中ナトリウムカリウム比と高血圧有病リスクとの関連 地域住民コホート調査

    小暮 真奈, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 清元 秀泰, 菊谷 昌浩, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 291-291 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  63. 東日本大震災後の家屋損壊程度と体脂肪率の関連 地域住民コホート調査

    中村 智洋, 中谷 直樹, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 292-292 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  64. 地域住民コホート調査における年齢別の中心血圧分布

    菊谷 昌浩, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 293-293 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  65. 頸動脈IMTとリスク因子の関連 東北メディカル・メガバンク計画地域住民コホート調査

    木皿 楓子, 土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 高井 貴子, 菊谷 昌浩, 目時 弘仁, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 293-293 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  66. 性・年齢階級別にみた家族との同居状況と心理的苦痛の関連 地域住民コホート調査

    及川 真紀, 佐藤 喜根子, 佐藤 眞理, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 富田 博秋, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 315-315 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  67. 地域住民コホート調査における家屋の被害の程度と平均歩数の関連

    中谷 直樹, 成田 暁, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 325-325 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  68. 東北メディカル・メガバンクにおける過敏性腸症候群の有病割合 地域住民コホート調査

    永家 聖, 中谷 直樹, 田中 由佳里, 金澤 素, 荻島 創一, 高井 貴子, 中村 智洋, 土屋 菜歩, 成田 暁, 栗山 進一, 田中 博, 辻 一郎, 呉 繁夫, 寳澤 篤, 福土 審

    日本公衆衛生学会総会抄録集 76回 395-395 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  69. 東日本大震災による家屋の被災状況と骨密度の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 409-409 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  70. 東北メディカル・メガバンク計画地域住民コホート調査における参加者の筋力について

    永井 雅人, 土屋 菜歩, 菊谷 昌浩, 中谷 直樹, 成田 暁, 中村 智洋, 小暮 真奈, 丹野 高三, 坂田 清美, 菅原 準一, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 652-652 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  71. 母体出生体重と妊娠高血圧症候群の関連 三世代コホート調査での検討

    和形 麻衣子, 土屋 菜歩, 中谷 直樹, 目時 弘仁, 寳澤 篤, 栗山 進一, 八重樫 伸生, 菅原 準一

    日本妊娠高血圧学会雑誌 24 58-58 2017年9月

    出版者・発行元:日本妊娠高血圧学会

    ISSN:1880-3172

  72. 飲酒量と推定食塩摂取量との関連:東北メディカル・メガバンク計画地域住民コホート調査

    小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 坪田(宇津木, 恵, 丹野高三, 寳澤篤

    日本アルコール・薬物医学会雑誌 52 (4) 204 2017年8月

    ISSN:1341-8963

  73. 東日本大震災被災コミュニティの就労状況と精神的健康に関する縦断的研究

    片柳 光昭, 瀬戸 萌, 根本 晴美, 菅原 由美, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小高 晃, 辻 一郎, 寳澤 篤, 富田 博秋

    日本社会精神医学会雑誌 26 (3) 240-241 2017年8月

    出版者・発行元:(一社)日本社会精神医学会

    ISSN:0919-1372

  74. 尿ナトカリ計を特定健康診査・特定保健指導に活用した自治体の新たな試み

    小暮 真奈, 宮川 健, 土屋 菜歩, 中村 智洋, 中谷 直樹, 安田 純, 寳澤 篤

    東北公衆衛生学会誌 (66) 21-21 2017年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  75. 性・年齢階級別にみた東日本大震災後の平均歩数 地域住民コホート調査

    中谷 直樹, 成田 暁, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    東北公衆衛生学会誌 (66) 29-29 2017年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  76. 性・年齢別に見た東日本大震災後の地域住民における腎機能と頸動脈内膜中膜複合体厚の関連

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 菊谷 昌浩, 丹野 高三, 菅原 準一, 清元 秀泰, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    東北公衆衛生学会誌 (66) 30-30 2017年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  77. 精神科病院に通院中の統合失調症患者におけるがん検診受診率 アンケートによる単施設横断研究

    藤原 雅樹, 稲垣 正俊, 中谷 直樹, 樋口 裕二, 藤森 麻衣子, 林原 千夏, 宋 龍平, 掛田 恭子, 児玉 匡史, 内富 庸介, 山田 了士

    精神神経学雑誌 (2017特別号) S291-S291 2017年6月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  78. Is Ecura System Useful for Deciding Treatment Strategy After Endoscopic Submucosal Dissection that Does Not Meet the Current Curative Criteria for Early Gastric Cancer? a Comparative Study

    Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY 85 (5) AB75-AB76 2017年5月

    出版者・発行元:MOSBY-ELSEVIER

    ISSN:0016-5107

    eISSN:1097-6779

  79. Does Submucosal Operation During Endoscopic Submucosal Dissection in Submucosal Invasive Gastric Cancer Enhance Lymph Node Metastasis and Prognosis?: A Multicenter Retrospective Study in Japan

    Hirotaka Ito, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Waku Hatta, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Ryo Shimoda, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY 85 (5) AB445-AB445 2017年5月

    出版者・発行元:MOSBY-ELSEVIER

    DOI: 10.1016/j.gie.2017.03.1036  

    ISSN:0016-5107

    eISSN:1097-6779

  80. 東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について 東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

    宮下 真子, 菊谷 昌浩, 田中 彰二, 山中 千鶴, 佐藤 ゆき, 水野 聖士, 石黒 真美, 小原 拓, 目時 弘仁, 成田 暁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌 (49) 14-14 2017年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  81. 東北メディカル・メガバンク事業 地域住民コホート(宮城県)の進捗とこれまでの成果で見えてきたこと

    寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 菊谷 昌浩, 小原 拓, 石黒 真美, 佐藤 ゆき, 山中 千鶴, 宮下 真子, 目時 弘仁, 栗山 進一, 辻 一郎

    宮城県公衆衛生学会会誌 (49) 17-17 2017年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  82. 自宅から最寄駅までの距離とBody Mass Indexの関連 震災後の住居による層別化解析

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫, 辻 一郎, 寳澤 篤

    宮城県公衆衛生学会会誌 (49) 18-18 2017年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  83. 東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較

    中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 100 (WEB ONLY) 2017年1月25日

  84. 東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 103 (WEB ONLY) 2017年1月25日

  85. 東日本大震災後における自宅から最寄駅までの距離とBMIの関連は食事パターンで説明できるか

    小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 88 (WEB ONLY) 2017年1月25日

  86. 東日本大震災後の内陸部と沿岸部の胃がんリスク比較

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫

    日本疫学会学術総会講演集(Web) 27th 130 (WEB ONLY) 2017年1月25日

  87. 東日本大震災後のメンタルヘルスの内陸‐沿岸較差:東北メディカル・メガバンク事業

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 冨田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 126 (WEB ONLY) 2017年1月25日

  88. 重症精神障害相当の心理的苦痛とがん検診受診行動との関連の検討―国民生活基礎調査匿名データの解析

    藤原雅樹, 稲垣正俊, 中谷直樹, 樋口裕二, 藤森麻衣子, 掛田恭子, 内富庸介, 山田了士

    日本疫学会学術総会講演集(Web) 27th 129 (WEB ONLY) 2017年1月25日

  89. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 飲酒と高血圧との関連はフラッシング反応により修飾されるか:NIPPON DATA2010

    小暮真奈, 土屋菜歩, 寳澤篤, 中谷直樹, 中村智洋, 宮松直美, 田中英夫, 若林一郎, 東山綾, 奥田奈賀子, 高嶋直敬, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web) 49‐50 (WEB ONLY) 2017年

  90. OMEGA-3 FATTY ACIDS FOR PREGNANT WOMEN WITH DEPRESSIVE SYMPTOMS IN JAPAN AND TAIWAN: AN OPEN-LABEL TRIAL

    D. Nishi, K. P. Su, K. Usuda, Y. J. Chiang, T. W. Guu, K. Hamazaki, N. Nakaya, T. Sone, Y. Sano, H. Ito, K. Isaka, K. Hashimoto, T. Hamazaki, Y. J. Matsuoka

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE 23 S20-S20 2016年11月

    出版者・発行元:SPRINGER

    ISSN:1070-5503

    eISSN:1532-7558

  91. 東日本大震災における外傷と心理的苦痛の関連 七ヶ浜健康増進プロジェクト

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集 75回 208-208 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  92. 東日本大震災被災状況とうつ病及びPTSD罹患リスクとの関連

    高梨 信之, 丹野 高三, 佐々木 亮平, 大塚 耕太郎, 坂田 清美, 中谷 直樹, 寳澤 篤, 栗山 進一, 辻 一郎, 中村 元行, 人見 次郎

    日本公衆衛生学会総会抄録集 75回 579-579 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  93. 東日本大震災被災地住民の健康知識に関連する要因の検討

    佐々木 亮平, 丹野 高三, 中谷 直樹, 寳澤 篤, 高梨 信之, 坂田 清美, 清水 厚志

    日本公衆衛生学会総会抄録集 75回 581-581 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  94. 東日本大震災後の自宅から最寄駅までの距離と高血圧治療中断に関する地理疫学的検討

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 75回 253-253 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  95. 東日本大震災後の身体活動量とこころの健康の関連 地域住民コホート調査

    中村 智洋, 中谷 直樹, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 富田 博秋, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 75回 288-288 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  96. 沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 富田 博秋, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 75回 303-303 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  97. 東日本大震災後の現在の居住地と食事パターンの関連 地域住民コホート調査

    小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 丹野 高三, 坂田 清美, 島津 太一, 菊谷 昌浩, 菅原 準一, 栗山 進一, 呉 繁夫, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 75回 304-304 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  98. 東北メディカル・メガバンク事業 地域住民コホート調査の進捗について

    寳澤 篤, 丹野 高三, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 佐々木 亮平, 高梨 信之, 坂田 清美, 菅原 準一, 栗山 進一, 中村 元行, 呉 繁夫, 辻 一郎

    日本公衆衛生学会総会抄録集 75回 381-381 2016年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  99. 妊婦におけるうつ症状軽減を目指したオメガ3系脂肪酸によるオープン試験

    西 大輔, Su Kuan-Pin, 臼田 謙太郎, Chiang Yi-Ju Jill, Guu Tai-Wei, 浜崎 景, 中谷 直樹, 曽根 稔雅, 佐野 養, 伊東 宏絵, 井坂 恵一, 橋本 謙二, 浜崎 智仁, 松岡 豊

    脂質栄養学 25 (2) 141-141 2016年8月

    出版者・発行元:日本脂質栄養学会

    ISSN:1343-4594

  100. Higher levels of gastrointestinal symptom-specific anxiety are associated with increased risk of presence of irritable bowel syndrome

    Tatsuo Saigo, Jun Tayama, Sayaka Ogawa, Atsushi Takeoka, Toyohiro Hamaguchi, Naoki Nakaya, Shin Fukudo, Susumu Shirabe

    INTERNATIONAL JOURNAL OF PSYCHOLOGY 51 146-146 2016年7月

    出版者・発行元:ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD

    ISSN:0020-7594

    eISSN:1464-066X

  101. 震災1年後の将来の住宅の見通しと心理的苦痛リスク

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 辻 一郎, 寳澤 篤, 富田 博秋

    東北公衆衛生学会誌 (65) 14-14 2016年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  102. 機能性ディスペプシアにおけるクロロゲン酸コーヒー飲料のディスペプシア症状および消化管ホルモンへの影響

    矢神 里紗, 庄司 知隆, 中谷 直樹, 中村 智洋, 遠藤 由香, 佐藤 康弘, 町田 知美, 町田 貴胤, 鹿野 理子, 金澤 素, 中谷 久美, 村椿 智彦, 相澤 祐一, 小室 葉月, 佐々木 彩加, 竹下 尚男, 水野 智仁, 渡辺 卓也, 福土 審

    心身医学 56 (6) 628-628 2016年6月

    出版者・発行元:(一社)日本心身医学会

    ISSN:0385-0307

  103. 東日本大震災1年後の沿岸部被災地における心理的苦痛と高血圧治療中断の関連 七ヶ浜健康増進プロジェクト

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 辻 一郎, 寳澤 篤, 富田 博秋

    日本循環器病予防学会誌 51 (2) 134-134 2016年5月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  104. 自宅から最寄駅までの距離と歩行習慣及びBody Mass Indexの関連 東北メディカル・メガバンク事業 地域住民コホート調査

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 清元 秀泰, 栗山 進一, 呉 繁夫, 辻 一郎, 寳澤 篤

    日本循環器病予防学会誌 51 (2) 124-124 2016年5月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  105. 東日本大震災後の宮城県沿岸部における治療中断東北メディカル・メガバンク事業 地域住民コホート調査

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 中谷 純, 峯岸 直子, 布施 昇男, 鈴木 洋一, 菅原 準一, 菊谷 昌浩, 富田 博秋, 清元 秀泰, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤, 丹野 高三, 佐々木 亮平, 坂田 清美

    宮城県公衆衛生学会会誌 (48) 11-11 2016年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  106. 随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

    寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

    Journal of Epidemiology (Web) 26 (Supplement 1) 123 2016年1月21日

    ISSN:1349-9092

  107. 東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    Journal of Epidemiology (Web) 26 (Supplement 1) 124 2016年1月21日

    ISSN:1349-9092

  108. 随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

    寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

    Journal of Epidemiology (Web) 26 (Supplement 1) 123 2016年1月21日

    ISSN:0917-5040

  109. 東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    Journal of Epidemiology (Web) 26 (Supplement 1) 124 2016年1月21日

    ISSN:0917-5040

  110. Estimation of allele frequency of pathological variants based on whole-genome sequencing of 1070 Japanese individuals

    Yumi Yamaguchi-Kabata, Yosuke Kawai, Kaname Kojima, Naoki Nariai, Takahiro Mimori, Yukuto Sato, Fumiki Katsuoka, Jun Yasuda, Masayuki Yamamoto, Masao Nagasaki

    GENES & GENETIC SYSTEMS 90 (6) 379-379 2015年12月

    出版者・発行元:GENETICS SOC JAPAN

    ISSN:1341-7568

    eISSN:1880-5779

  111. Whole-genome Japanese Reference Panel and future directions

    Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Pan Xiaoqing, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    GENES & GENETIC SYSTEMS 90 (6) 377-377 2015年12月

    出版者・発行元:GENETICS SOC JAPAN

    ISSN:1341-7568

    eISSN:1880-5779

  112. 東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

    寳澤 篤, 清元 秀泰, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小原 拓, 目時 弘仁, 丹野 高三, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之

    日本公衆衛生学会総会抄録集 74回 260-260 2015年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  113. 東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

    寳澤 篤, 清元 秀泰, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小原 拓, 目時 弘仁, 丹野 高三, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之

    日本公衆衛生学会総会抄録集 74回 260-260 2015年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  114. 東日本大震災後の高血圧の治療中断と関連する要因 地域住民コホート調査

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 丹野 高三, 佐々木 亮平, 坂田 清美, 中谷 純, 菊谷 昌浩, 清元 秀泰, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤

    日本公衆衛生学会総会抄録集 74回 261-261 2015年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  115. 東日本大震災後の宮城県における歯科受診状況と関連因子についての検討

    土屋 菜歩, 坪井 明人, 白石 成, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 鈴木 洋一, 菊谷 昌浩, 富田 博秋, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤

    日本公衆衛生学会総会抄録集 74回 261-261 2015年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  116. 宮城県地域住民における心理的苦痛と喫煙行動の関連についての検討

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 富田 博秋, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤

    日本公衆衛生学会総会抄録集 74回 296-296 2015年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  117. 東日本大震災後の睡眠薬服用開始に関連する規定要因の検討 地域住民コホート調査

    中村 智洋, 富田 博秋, 中谷 直樹, 土屋 菜歩, 成田 暁, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤, 丹野 高三, 佐々木 亮平, 坂田 清美

    日本公衆衛生学会総会抄録集 74回 296-296 2015年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  118. 東北メディカル・メガバンク 地域住民コホート宮城エリアにおける随時尿Na/K比の内陸部・沿岸部比較

    寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 中谷 純, 峯岸 直子, 清元 秀泰, 菅原 準一, 布施 昇男, 菊谷 昌浩, 鈴木 洋一, 富田 博秋, 栗山 進一, 辻 一郎, 呉 繁夫, 八重樫 伸生, 山本 雅之

    日本循環器病予防学会誌 50 (2) 126-126 2015年6月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  119. 東日本大震災後の小中学生の保護者が抱く子どもの不安と悩みの特徴 宮城県南部の実態調査から

    佐藤 ゆき, 菊谷 昌浩, 宮下 真子, 山中 千鶴, 石黒 真美, 小原 拓, 目時 弘仁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 呉 繁夫, 八重樫 伸生, 栗山 進一

    小児保健研究 74 (講演集) 139-139 2015年5月

    出版者・発行元:(公社)日本小児保健協会

    ISSN:0037-4113

  120. Irritable Bowel Syndrome in university students is associated with higher experiencing maladjustment and employment anxiety

    J. Tayama, N. Nakaya, T. Hamaguchi, T. Saigo, S. Ogawa, T. Sone, S. Fukudo, S. Susumu

    PSYCHOTHERAPY AND PSYCHOSOMATICS 84 71-71 2015年

    出版者・発行元:KARGER

    ISSN:0033-3190

    eISSN:1423-0348

  121. 東日本大震災被災者の喪失と悲嘆のプロファイル

    小林奈津子, 新宮古都美, 庄子朋香, 北田友子, 中谷直樹, 中村智洋, 土屋菜歩, 吉田弘和, 菊地紗耶, 本多奈美, 松岡洋夫, 中島聡美, 寳澤篤, 辻一郎, 富田博秋

    日本精神神経学会総会プログラム・抄録集 111th (2015特別) S.364-S364 2015年

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  122. Psychosocial Longitudinal Study Profile and Distress of Couples in Relation to the Conduct of Prostate Biopsy

    Akira Oba, Naoki Nakaya, Masaru Hasumi, Kumiko Yanaba-Ono, Kumi Saito-Nakaya, Hiroyuki Takechi, Seiji Arai, Nobuaki Shimizu

    PSYCHO-ONCOLOGY 23 406-406 2014年10月

    出版者・発行元:WILEY-BLACKWELL

    ISSN:1057-9249

    eISSN:1099-1611

  123. 東日本大震災での笑いの規定要因と精神的健康度の推測 七ヶ浜健康増進プロジェクト

    中村 智洋, 中谷 直樹, 土屋 菜歩, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集 73回 239-239 2014年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  124. 東日本大震災の被災地における慢性疾患治療と就労の関連 七ヶ浜健康増進プロジェクト

    中谷 直樹, 中村 智洋, 土屋 菜歩, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集 73回 270-270 2014年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  125. ソーシャルキャピタルと健康状態との関連 家屋の被災程度との交互作用の検討

    土屋 菜歩, 中谷 直樹, 中村 智洋, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集 73回 480-480 2014年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  126. NEUROTICISM AND IRRITABLE BOWEL SYNDROME

    J. Tayama, S. Fukudo, N. Nakaya, T. Hamaguchi, T. Tomiie, M. Shinozaki, T. Saigo, S. Shirabe

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE 21 S128-S129 2014年8月

    出版者・発行元:SPRINGER

    ISSN:1070-5503

    eISSN:1532-7558

  127. 過敏性腸症候群の大学生における修業状況 心身症のモデル病態における修業上の問題

    田山 淳, 西郷 達雄, 小川 さやか, 中谷 直樹, 濱口 豊太, 福士 審, 林田 雅希, 調 漸

    全国大学保健管理研究集会プログラム・抄録集 52回 44-44 2014年8月

    出版者・発行元:(公社)全国大学保健管理協会

  128. 各種災害関連ストレスが東日本大震災沿岸部被災者の精神的健康に及ぼす影響の検討

    鈴木 大輔, 中谷 直樹, 中村 智洋, 中島 聡美, 金 吉晴, 辻 一郎, 寳澤 篤, 富田 博秋

    日本社会精神医学会雑誌 23 (3) 259-259 2014年8月

    出版者・発行元:(一社)日本社会精神医学会

    ISSN:0919-1372

  129. うつ予防を目的とした集団認知行動療法の効果 ハイリスクな大学新入生への介入 査読有り

    田山 淳, 西郷 達雄, 小川 さやか, Bernick Peter, 福原 視美, 濱口 豊太, 富家 直明, 中谷 直樹, 林田 雅希, 調 漸

    CAMPUS HEALTH 51 (1) 455-457 2014年3月

    出版者・発行元:(公社)全国大学保健管理協会

    ISSN:1341-4313

    eISSN:2432-9460

    詳細を見る 詳細を閉じる

    うつ予防を自的とした集団認知行動療法の効果について検討した。新入生1685例に対して、入学前にメンタルヘルス問診票を配布した。約2%、30例強が従来のハイリスクアプローチの対象のうち、249例(約15%)が高損害回避学生であった。249例に対して、説明会への参加登録、インフォームドコンセント、MINIによる除外診断面接を実施し、22例が参加した。データ解析の対象者は12例であった。集団認知行動療法の実施により、介入前に比べて介入直後の時点でポジティブ自己認知スコアの有意な上昇を認めた。さらに、介入前に比べて介入から半年後の時点においてもポジティブ自己認知スコアの有意な上昇を認めた。しかし、介入の3セッション後、及び介入から1年後のポジティブ自己認知スコアについては、介入前のスコアに比べて有意なスコアの上昇は認めなかった。集団認知行動療法により、うつ症状のスコアの低下は認めなかった。

  130. 東北メディカル・メガバンク事業―地域住民コホート調査に関する経過報告

    寶澤篤, 寶澤篤, 寶澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之

    J Epidemiol 24 (Supplement 1) 67 2014年1月23日

    ISSN:0917-5040

  131. 東北メディカル・メガバンク事業―三世代コホート調査に関する経過報告

    目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生

    J Epidemiol 24 (Supplement 1) 67 2014年1月23日

    ISSN:0917-5040

  132. 慢性疾患治療者における心理的苦痛に関する研究 七ヶ浜健康増進プロジェクト

    中谷 直樹, 中村 智洋, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集 72回 198-198 2013年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  133. 東日本大震災における喫煙・飲酒の行動変化と規定要因 七ヶ浜健康増進プロジェクト

    中村 智洋, 中谷 直樹, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集 72回 198-198 2013年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  134. 過敏性腸症候群に対する自律訓練法のエビデンス

    篠崎雅江, 金澤素, 鹿野理子, 遠藤由香, 中谷直樹, 本郷道夫, 福土審

    日本自律訓練学会大会プログラム・発表抄録集 36th 23-23 2013年9月6日

    出版者・発行元:日本自律訓練学会

  135. 震災救援者におけるPTSD症状の予測因子に関する検討

    西 大輔, 中谷 直樹, 曽根 稔雅, 野口 普子, 浜崎 景, 浜崎 智仁, 小井土 雄一, 松岡 豊

    国立精神・神経医療研究センター精神保健研究所年報 (26) 247-247 2013年9月

    出版者・発行元:(国研)国立精神・神経医療研究センター精神保健研究所

  136. 東日本大震災沿岸部被災者の精神的健康の変遷と現況

    鈴木 大輔, 築田 美抄, 上田 穫, 中谷 直樹, 金 吉晴, 辻 一郎, 寶澤 篤, 富田 博秋

    精神神経学雑誌 (2013特別) S-568 2013年5月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  137. FISH OIL FOR ATTENUATING POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE: A RANDOMIZED CONTROLLED TRIAL

    Yutaka Matsuoka, Daisuke Nishi, Yu-ichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki

    PSYCHOSOMATIC MEDICINE 75 (3) A131-A131 2013年4月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    ISSN:0033-3174

    eISSN:1534-7796

  138. PERITRAUMATIC DISTRESS, WATCHING TELEVISION AND POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE

    Daisuke Nishi, Yu-ichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka

    PSYCHOSOMATIC MEDICINE 75 (3) A103-A103 2013年4月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    ISSN:0033-3174

    eISSN:1534-7796

  139. 大学生のメンタルヘルスとIBS

    田山淳, 中谷直樹, 濱口豊太, 富家直明, 篠崎雅江, 西郷達雄, 調漸, 福土審

    行動医学研究 19 (Supplement) 55 2013年3月

    ISSN:1341-6790

  140. 睡眠時間と総死亡・死因別死亡リスク 大崎国保コホート研究

    柿崎 真沙子, 栗山 進一, 中谷 直樹, 曽根 稔雅, 永井 雅人, 菅原 由美, 寳澤 篤, 辻 一郎

    宮城県公衆衛生学会会誌 (45) 4-4 2013年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  141. FISH OIL FOR ATTENUATING POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE: A RANDOMIZED CONTROLLED TRIAL

    D. Nishi, Y. Koido, N. Nakaya, T. Sone, H. Noguchi, K. Hamazaki, T. Hamazaki, Y. Matsuoka

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE 19 S21-S22 2012年9月

    出版者・発行元:SPRINGER

    ISSN:1070-5503

    eISSN:1532-7558

  142. THE EFFECTS OF PERSONALITY ON IRRITABLE BOWEL SYNDROME

    J. Tayama, N. Nakaya, T. Hamaguchi, T. Tomiie, M. Shinozaki, T. Saigo, M. Hayashida, S. Fukudo

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE 19 S55-S55 2012年9月

    出版者・発行元:SPRINGER

    ISSN:1070-5503

    eISSN:1532-7558

  143. 高齢者における心理的苦痛と要介護認定・死亡リスクの関連:大崎コホート2006研究

    渡邉崇, 柿崎真沙子, 中谷直樹, 中谷直樹, 永井雅人, 遠又靖丈, 坪谷透, 栗山進一, 栗山進一, 辻一郎

    日本公衆衛生学会総会抄録集 70th 276 2011年10月15日

    ISSN:1347-8060

  144. ソーシャルキャピタルの地域差に関する研究

    坪谷透, 栗山進一, 遠又靖丈, 中谷直樹, 大森(松田)芳, 高橋英子, 寳澤篤, 福地成, 曽根稔雅, 永井雅人, 菅原由美, 星玲奈, 柿崎真沙子, 辻一郎

    宮城県公衆衛生学会会誌 (43) 11-11 2011年6月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  145. Relationship between Peripheral Arterial Disease and Incident Disability among Japanese Elderly: the Tsurugaya Project.

    A. Nitta, A. Hozawa, S. Kuriyama, N. Nakaya, K. Ohmori-Matsuda, T. Sone, M. Kakizaki, N. Tomita, S. Ebihara, K. Furukawa, M. Ichiki, H. Arai, I. Tsuji

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 59 S37-S37 2011年4月

    出版者・発行元:WILEY-BLACKWELL

    ISSN:0002-8614

  146. 大学生版食行動質問票の開発 項目反応理論を用いた尺度の精査及び信頼性・妥当性の検証 査読有り

    田山 淳, 山崎 浩則, 林田 雅希, 玉井 慎美, 木村 拓也, 中垣内 真樹, 富家 直明, 濱口 豊太, 中谷 直樹, 山本 玲子, 福士 審, 調 漸

    CAMPUS HEALTH 48 (1) 186-188 2011年2月

    出版者・発行元:(公社)全国大学保健管理協会

    ISSN:1341-4313

    eISSN:2432-9460

  147. 睡眠時間と要介護認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

    柿崎真沙子, 上川康貴, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一, 辻一郎

    J Epidemiol 21 (1 Supplement) 106 2011年1月21日

    ISSN:0917-5040

  148. パーソナリティーと全死因死亡リスクに関する前向きコホート研究:宮城県コホート研究

    丹治史也, 柿崎真沙子, 菅原由美, 渡邊生恵, 中谷直樹, 西野善一, 南優子, 深尾彰, 辻一郎

    J Epidemiol 21 (1 Supplement) 88 2011年1月21日

    ISSN:0917-5040

  149. 介護予防サービスの効果評価に関する研究 1日の総睡眠時間,夜間睡眠時間,要介護認定の関連についての前向きコホート研究—鶴ケ谷プロジェクト—

    辻一郎, 柿崎真沙子, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一

    介護予防サービスの効果評価に関する研究 平成22年度総括・分担研究報告書 56-60 2011年

  150. 高齢者におけるNT‐Pro BNPと要介護認定の関連—鶴ケ谷コホート研究—

    寶澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 大森芳, 中谷直樹, 栗山進一, 深尾彰, 辻一郎

    日本高血圧学会総会プログラム・抄録集 33rd 380 2010年10月15日

  151. 大学生版食行動質問票の開発 項目反応理論を用いた尺度の精査及び信頼性・妥当性の検証

    田山 淳, 山崎 浩則, 林田 雅希, 玉井 慎美, 木村 拓也, 中垣内 真樹, 富家 直明, 濱口 豊太, 中谷 直樹, 山本 玲子, 福土 審, 調 漸

    CAMPUS HEALTH 47 (3) 75-75 2010年10月

    出版者・発行元:(公社)全国大学保健管理協会

    ISSN:1341-4313

    eISSN:2432-9460

  152. うつ状態と介護保険要支援・要介護認定リスクとの関連 鶴ヶ谷プロジェクト

    大森 芳, 松田, 寳澤 篤, 曽根 稔雅, 小泉 弥生, 宗, 中谷 直樹, 栗山 進一, 鈴木 修治, 粟田 主一, 辻 一郎

    日本公衆衛生雑誌 57 (7) 538-549 2010年7月

    出版者・発行元:日本公衆衛生学会

    DOI: 10.11236/jph.57.7_538  

    ISSN:0546-1766

    詳細を見る 詳細を閉じる

    目的 地域高齢者におけるうつ状態の程度とその後の介護保険の要支援・要介護認定リスクとの関連をコホート研究により検討すること、さらにその関連に男女差があるかを検討すること。方法 仙台市宮城野区鶴ヶ谷地区の70歳以上住民全員(2925人)に対し、高齢者総合機能評価「寝たきり予防健診」を平成15年に行った。受診者(958人)のうち、研究利用への同意が得られ介護保険認定非該当であった者841人を解析対象とした。うつ状態は30項目のGeriatric Depression Scale(GDS)で評価した。抗うつ薬内服またはGDS14点以上(中等度〜重度うつ群)、10-13点(軽度うつ群)、9点以下(健常)の3群に分類し要支援・要介護認定リスクをCox比例ハザードモデルにより算出した。結果 4年間の追跡調査で151人が要支援・要介護認定を受け、46人が死亡した。うつ状態は特に男性において要支援・要介護認定リスクと関連していた。男性では、健常群と比較した要支援・要介護認定の年齢補正ハザード比は、軽度うつ群で1.77(95%信頼区間(CI):0.91-3.48)、中等度〜重度うつ群で2.26(1.11-4.64)と、うつ状態の程度とともに有意に増加した(傾向性のP値=0.023)。これは、疾患既往歴、ソーシャルサポートの有無、喫煙、認知機能などの影響を補正しても変わらなかった(多変量補正ハザード比;軽度うつ群:1.31(95%CI:0.65-2.65)、中等度〜重度うつ群:2.19(1.06-4.54)、傾向性のP=0.034)。一方、女性では、うつ状態と要支援・要介護認定リスクとの間に有意な関連は認められなかった。また、うつ状態と死亡リスクには男女ともに有意な関連は認められなかった。結論 うつ状態と要支援・要介護認定リスクは、男性でのみ有意な関連が認められた。それは、ベースラインの既往歴、心身機能、社会的要因、生活習慣を補正してもなお認められた。うつ状態の要支援・要介護認定発生への影響は男女で異なる可能性が示唆された。地域高齢者のうつ対策が、生活の質の向上のみでなく、特に男性高齢者において、介護予防に重要であることが示された。(著者抄録)

  153. 緑茶摂取と肝がん罹患に関する前向きコホート研究

    宇井あかね, 栗山進一, 柿崎真沙子, 曽根稔雅, 中谷直樹, 大森(松田)芳, 寳澤篤, 西野善一, 辻一郎

    J Epidemiol 20 (Supplement 1) S112 2010年1月9日

    ISSN:0917-5040

  154. Impact of physical activity and performance on medical care costs among the Japanese elderly

    Yang G, Niu K, Fujita K, Hozawa A, Ohmori-Matsuda K, Kuriyama S, Nakaya N, Ebihara S, Okazaki T, Guo H, Miura C, Takahashi H, Arai H, Tsuji I, Nagatomi R

    Geriatr Gerontol Int 00 (00) 000-000 2010年

    DOI: 10.1111/j.1447-0594.2010.00651.x.  

  155. 介護予防サービスの効果評価に関する研究 緑茶摂取と肺炎死亡リスクに関する研究

    辻一郎, 渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 寳澤篤

    介護予防サービスの効果評価に関する研究 平成21年度総括・分担研究報告書 59-64 2010年

  156. 高齢者における血圧と要介護認定の関連 鶴ヶ谷コホート研究

    寳澤 篤, 栗山 進一, 大森 芳, 曽根 稔雅, 新田 明美, 菅原 由美, 中谷 直樹, 牛 凱軍, 粟田 主一, 辻 一郎

    日本高血圧学会総会プログラム・抄録集 32回 304-304 2009年10月

    出版者・発行元:(NPO)日本高血圧学会

  157. 緑茶摂取頻度とK6得点との関連—大崎コホート2006研究—

    寳澤篤, 栗山進一, 中谷直樹, 大森芳, 柿崎真沙子, 曽根稔雅, 永井雅人, 新田明美, 菅原由美, 牛凱軍, 辻一郎

    J Epidemiol 19 (1 Supplement) 210 2009年1月24日

    ISSN:0917-5040

  158. Motor Fitness Scaleと要介護発生・死亡リスクに関する前向きコホート研究—鶴ケ谷プロジェクト—

    星真行, 星真行, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 牛凱軍, 藤田和樹, 植木章三, 芳賀博, 永富良一, 辻一郎

    J Epidemiol 19 (1 Supplement) 198 2009年1月24日

    ISSN:0917-5040

  159. 睡眠時間と乳がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

    柿崎真沙子, 柿崎真沙子, 栗山進一, 曽根稔雅, 大森芳, 寳澤篤, 中谷直樹, 福土審, 辻一郎

    J Epidemiol 19 (1 Supplement) 67 2009年1月24日

    ISSN:0917-5040

  160. 末梢動脈疾患と要介護発生に関する前向きコホート研究〜鶴ケ谷プロジェクト〜

    新田明美, 新田明美, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 海老原覚, 市来正隆, 荒井啓行, 辻一郎

    J Epidemiol 19 (1 Supplement) 199 2009年1月24日

    ISSN:0917-5040

  161. 要介護認定者における要介護状態区分の推移に関する研究

    曽根 稔雅, 中谷 直樹, 大森 芳, 寳澤 篤, 栗山 進一, 辻 一郎

    日本公衆衛生学会総会抄録集 67回 519-519 2008年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  162. Sense of life worth living (ikigai) and mortality in Japan: Ohsaki Study

    Toshimasa Sone, Naoki Nakaya, Kaori Ohmori, Taichi Shimazu, Mizuka Higashiguchi, Masako Kakizaki, Nobutaka Kikuchi, Shinichi Kuriyama, Ichiro Tsuji

    PSYCHOSOMATIC MEDICINE 70 (6) 709-715 2008年7月

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1097/PSY.0b013e31817e7e64  

    ISSN:0033-3174

    詳細を見る 詳細を閉じる

    Objective: To investigate the association between the sense of "life worth living (ikigai)" and the cause-specific mortality risk. The psychological factors play important roles in morbidity and mortality risks. However, the association between the negative psychological factors and the risk of mortality is inconclusive. Methods: The Ohsaki Study, a prospective cohort study, was initiated on 43,391 Japanese adults. To assess if the subjects found a sense of ikigai, they were asked the question, "Do you have ikigai in your life?" We used Cox regression analysis to calculate the hazard ratio of the all-cause and cause-specific mortality according to the sense of ikigai categories. Results: Over 7 years' follow-up, 3048 of the subjects died. The risk of all-cause mortality was significantly higher among the subjects who did not find a sense of ikigai as compared with that in the subjects who found a sense of ikigai; the multivariate adjusted hazard ratio (95% confidence interval) was 1.5 (1.3-1.7). As for the cause-specific mortality, subjects who did not find a sense of ikigai were significantly associated with an increased risk of cardiovascular disease (1.6; 1.3-2.0) and external cause mortality (1.9; 1.1-3.3), but not of the cancer mortality (1.3; 1.0-1.6). Conclusions: In this prospective cohort study, subjects who did not find a sense of ikigai were associated with an increased risk of all-cause mortality. The increase in mortality risk was attributable to cardiovascular disease and external causes, but not cancer.

  163. 自殺問題と予防対策:厚生労働省戦略研究 都市における自殺予防対策

    粟田 主一, 今城 周造, 滑川 明夫, 中谷 直樹, 小泉 弥生, 井藤 佳恵, 本多 奈美, 新解 敏恭, 岡崎 伸郎, 並河 紋子, 菅原 広子

    精神神経学雑誌 110 (3) 222-229 2008年3月

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  164. 【ストレスと疾患の関係】 ストレスとがん罹患リスクに関する疫学研究

    中谷 直樹, 内富 庸介

    ストレス科学研究 23 1-7 2008年3月

    出版者・発行元:(公財)パブリックヘルスリサーチセンター

    ISSN:1341-9986

  165. 高感度C反応性蛋白レベルと介護保険認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

    曽根稔雅, 牛凱軍, 中谷直樹, 大森芳, 東口みづか, 柿崎真沙子, 寳澤篤, 栗山進一, 辻一郎

    J Epidemiol 18 (1 Supplement) 122 2008年1月25日

    ISSN:0917-5040

  166. 睡眠時間と前立腺がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

    柿崎真沙子, 柿崎真沙子, 井上圭祐, 栗山進一, 中谷直樹, 曽根稔雅, 大森芳, 福土審, 辻一郎

    J Epidemiol 18 (1 Supplement) 54 2008年1月25日

    ISSN:0917-5040

  167. 緑茶摂取と肺炎死亡リスクに関する前向きコホート研究:大崎国保コホート研究

    渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 辻一郎

    J Epidemiol 18 (1 Supplement) 210 2008年1月25日

    ISSN:0917-5040

  168. 初産年齢と長期的死亡リスクに関する前向きコホート研究:大崎国保コホート研究

    酒井太一, 中谷直樹, 角田雪香, 柿崎真沙子, 曽根稔雅, 大森芳, 栗山進一, 辻一郎

    J Epidemiol 18 (1 Supplement) 108 2008年1月25日

    ISSN:0917-5040

  169. Does nocturia increase fall-related fractures and mortality in a community-dwelling elderly population aged 70 years and over? Results of a 3-year prospective cohort study in Japan

    H. Nakagawa, Y. Ikeda, K. Niu, Y. Kaiho, K. Ohmori-Matsuda, N. Nakaya, R. Imanishi, R. Nagatomi, Tsuji, I, Y. Arai

    NEUROUROLOGY AND URODYNAMICS 27 (7) 674-675 2008年

    出版者・発行元:WILEY-BLACKWELL

    ISSN:0733-2467

  170. 生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究 生活習慣,既往歴,日常生活の状況,人生観,健診・検診受診歴が医療費に及ぼす影響に関する研究—大崎国保コホート研究—

    辻一郎, 栗山進一, 渡邊生恵, 柿崎真沙子, 中谷直樹, 大森芳

    生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究 平成19年度研究報告書 11-20 2008年

  171. 生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究 生活習慣,既往歴,日常生活の状況,人生観,健診・検診受診歴が死亡リスクに及ぼす影響に関する研究—大崎国保コホート研究—

    辻一郎, 渡邊生恵, 柿崎真沙子, 栗山進一, 中谷直樹, 大森芳

    生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究 平成19年度研究報告書 21-29 2008年

  172. 高齢者での低レベルの血清CRP濃度と体力低下との関連

    牛 凱軍, 寳澤 篤, 郭 輝, 栗山 進一, 楊 光, 大森 芳, 中谷 直樹, 高橋 英子, 藤田 和樹, 辻 一郎, 永富 良一

    体力科学 56 (6) 806-806 2007年12月

    出版者・発行元:(一社)日本体力医学会

    ISSN:0039-906X

    eISSN:1881-4751

  173. 睡眠時間と死亡リスクに関する前向きコホート研究:大崎コホート研究 (Supplement to Journal of Epidemiology)

    柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 福土審, 辻一郎

    Supplement to Journal of Epidemiology 96 2007年10月

  174. 心理社会的要因とがん罹患/生存--パーソナリティを中心として

    中谷 直樹

    腫瘍内科 1 (4) 383-388 2007年8月

    出版者・発行元:科学評論社

    ISSN:1881-6568

  175. 効果的な介護予防ケアマネジメント技法の開発に関する研究 生きがいと死亡リスクに関する前向きコホート研究

    辻一郎, 曽根稔雅, 栗山進一, 中谷直樹, 大森芳, 島津太一, 菊地信孝, 柿崎真沙子

    効果的な介護予防ケアマネジメント技法の開発に関する研究 平成18年度 研究報告書 34-43 2007年

  176. Personality traits and cancer survival: a Danish cohort study (vol 95, pg 146, 2006)

    N. Nakaya, P. E. Hansen, I. R. Schapiro, L. F. Eplov, K. Saito-Nakaya, Y. Uchitomi, C. Johansen

    BRITISH JOURNAL OF CANCER 95 (11) 1610-1610 2006年12月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/sj.bjc.6603489  

    ISSN:0007-0920

  177. パーソナリティと胃がん検診受診行動に関する横断研究

    荒井志津葉, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 辻一郎

    日本公衆衛生学会総会抄録集 65th 275 2006年10月15日

    ISSN:1347-8060

  178. コーヒー摂取と大腸がん罹患リスクに関する前向きコホート研究

    長沼透, 栗山進一, ムニラ アクタル, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 辻一郎

    日本公衆衛生学会総会抄録集 65th 274 2006年10月15日

    ISSN:1347-8060

  179. パーソナリティとがん患者の生命予後:宮城県コホート研究

    中谷 直樹, 坪野 吉孝, 西野 善一, 細川 徹, 福土 審, 渋谷 大助, 中谷 久美, 内富 庸介, 辻 一郎

    東北公衆衛生学会誌 (55) 37-37 2006年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  180. アルコール摂取の発がん影響に関する疫学研究 : 人口寄与危険割合の推定

    辻 一郎, 中谷 直樹, 栗山 進一

    日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 41 (3) 196-197 2006年6月28日

    ISSN:1341-8963

  181. 【わが国におけるがん検診の現状と問題点】 がん検診の意義 地域格差 (クリニカルプラクティス)

    中谷直樹, 辻一郎

    クリニカルプラクティス 25 (4) 245-249 2006年4月

  182. Personality and cancer survival: The Miyagi Cohort Study

    N Nakaya, Y Tsubono, Y Nishino, T Hosokawa, S Fukudo, D Shibuya, N Aki-zuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Saito-Nakaya, Y Uchitomi, Tsuji, I

    JOURNAL OF PSYCHOSOMATIC RESEARCH 58 (6) S42-S42 2005年6月

    出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD

    ISSN:0022-3999

  183. Efficacy of autogenic training for patients with irritable bowel syndrome

    M Shinozaki, M Kano, M Kanazawa, N Nakaya, Y Endo, M Hongo, S Fukudo

    JOURNAL OF PSYCHOSOMATIC RESEARCH 58 (6) S54-S54 2005年6月

    出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD

    ISSN:0022-3999

  184. 【サイコオンコロジーと心身医療】 がんと疫学

    中谷 直樹, 清水 研, 大庭 章, 内富 庸介, 坪野 吉孝

    心療内科 9 (2) 95-100 2005年3月

    出版者・発行元:(有)科学評論社

    ISSN:1342-9892

  185. 心身症の診断・治療ガイドラインを用いた評価法の開発に関する研究 過敏性腸症候群の症状評価法の開発と診断・治療ガイドラインの検証に関する研究

    福土審, 篠崎雅江, 鹿野理子, 金沢素, 中谷直樹, 吉沢正彦, 遠藤由香, 本郷道夫

    心身症の診断・治療ガイドラインを用いた評価法の開発に関する研究 平成14-16年度 総括研究報告書 73-109 2005年

  186. Personality and the risk of cancer

    N Nakaya, Y Tsubono, T Hosokawa, S Fukudo, Tsuji, I

    PSYCHO-ONCOLOGY 13 (8) S4-S5 2004年8月

    出版者・発行元:JOHN WILEY & SONS LTD

    ISSN:1057-9249

  187. 肉類摂取と大腸がん罹患に関する前向きコホート研究

    佐藤 ゆき, 中谷 直樹, 栗山 進一, 西野 善一, 坪野 吉孝, 辻 一郎

    東北公衆衛生学会誌 (53) 25-25 2004年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  188. パーソナリティーとがん罹患に関する前向きコホート研究(シンポジウム/サイコオントロジーの新たな展開)(第44回日本心身医学会総会)

    中谷 直樹, 坪野 吉孝, 細川 徹, 西野 善一, 大久保 孝義, 寶澤 篤, 渋谷 大助, 福土 審, 深尾 彰, 辻 一郎, 久道 茂

    心身医学 44 (7) 471-477 2004年7月1日

    出版者・発行元:日本心身医学会

    DOI: 10.15064/jjpm.44.7_471  

    ISSN:0385-0307

    詳細を見る 詳細を閉じる

    パーソナリティーとがん罹患リスクとの関連を,7年間の前向きコホート研究にて検討した.40〜64歳の一般地域住民30,277名を解析対象とした.Eysenck Personality Questionnaire-Revised(EPQ-R)の「E尺度(extraversion);外向性傾向」「N尺度(neuroticlsm);神経症傾向」「P尺度(psychoticism);非協調性」「L尺度(lie);虚構性」の4つの下位尺度が,がん罹患リスクに及ぼす影響は認められなかった.しかしながら,神経症傾向が,がん罹患の原因ではなく結果である可能性が示唆された.

  189. 飲酒と全死因死亡に関する前向きコホート研究

    倉嶋 佳誉子, 中谷 直樹, 山口 純子, 大久保 孝義, 西野 善一, 坪野 吉孝, 辻 一郎, 久道 茂, 福土 審

    宮城県公衆衛生学会会誌 (36) 6-6 2004年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  190. 性格と癌罹患に関する前向きコホート研究(第55回日本心身医学会東北地方会演題抄録)

    中谷 直樹, 坪野 吉孝, 西野 善一, 大久保 孝義, 寶澤 篤, 細川 徹, 渋谷 大助, 福土 審, 辻 一郎

    心身医学 44 (2) 153-153 2004年2月1日

    出版者・発行元:日本心身医学会

    DOI: 10.15064/jjpm.44.2_153_1  

    ISSN:0385-0307

  191. Re: Personality and the risk of cancer (multiple letters) [1]

    Christian Murr, Dietmar Fuchs, Yoshitaka Tsubono, Naoki Nakaya, Ichiro Tsuji

    Journal of the National Cancer Institute 95 (21) 1638 2003年11月5日

    ISSN:0027-8874

  192. Re: Personality and the risk of cancer - Response

    Y Tsubono, N Nakaya, Tsuji, I

    JOURNAL OF THE NATIONAL CANCER INSTITUTE 95 (21) 1638-1638 2003年11月

    出版者・発行元:OXFORD UNIV PRESS INC

    DOI: 10.1093/jnci/djg093  

    ISSN:0027-8874

  193. 高齢者における過敏性腸症候群及び機能性消化管障害の抑うつ症状とQuality of Life

    中谷 直樹, 藤田 和樹, 寳澤 篤, 小泉 弥生, 大森 芳, 倉嶋 佳誉子, 辻 一郎, 粟田 主一, 福土 審

    老年精神医学雑誌 14 (5) 628-628 2003年5月

    出版者・発行元:(株)ワールドプランニング

    ISSN:0915-6305

  194. 岩手県大迫町における運動訓練の効果-筋力,バランスなど

    藤田 和樹, 寳澤 篤, 中谷 直樹, 大森 芳, 鈴木 寿則, 山口 純子, 辻 一郎, 古川 順光, 佐藤 浩哉, 永富 良一

    宮城県公衆衛生学会会誌 (35) 7-7 2003年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  195. がんの病前性格 (サイコオンコロジー--がん患者のこころのケア) -- (がん患者への告知と情緒状態)

    中谷 直樹, 福土 審

    現代のエスプリ (426) 53-62 2003年1月

    出版者・発行元:至文堂

    ISSN:0435-2165

  196. Association between depression and social support in the Japanese elderly population

    Y Koizumi, S Awata, T Seki, N Nakaya, S Kuriyama, K Fujita, K Ohmori, A Hozawa, S Ebihara, H Arai, R Nagatomi, H Matsuoka, Tsuji, I

    INTERNATIONAL PSYCHOGERIATRICS 15 272-272 2003年

    出版者・発行元:SPRINGER PUBLISHING CO

    ISSN:1041-6102

  197. 緑茶と胃がん罹患に関する前向きコホート研究

    小泉 弥生, 坪野 吉孝, 中谷 直樹, 西野 善一, 辻 一郎, 渋谷 大助, 松岡 洋夫, 久道 茂

    Journal of epidemiology 12 (1) 77-77 2002年1月1日

    ISSN:0917-5040

  198. 緑茶と大腸がん罹患に関する前向きコホート研究

    鈴木 寿則, 坪野 吉孝, 中谷 直樹, 西野 善一, 辻 一郎, 渋谷 大助, 久道 茂

    Journal of epidemiology 12 (1) 110-110 2002年1月1日

    ISSN:0917-5040

  199. 緑茶と乳がん罹患に関する前向きコホート研究

    鈴木 洋子, 坪野 吉孝, 中谷 直樹, 西野 善一, 辻 一郎, 渋谷 大助, 久道 茂

    Journal of epidemiology 12 (1) 111-111 2002年1月1日

    ISSN:0917-5040

  200. アルコール摂取とがん罹患に関する前向きコホート研究

    中谷直樹, 西野善一, 坪野吉孝, 辻一郎, 渋谷大助, 福土審, 久道茂

    Journal of epidemiology 12 (1) 98-98 2002年1月1日

    ISSN:0917-5040

  201. IID-12 少年院入院者に対するリラクセーションによる心理的変化(小児科III)

    中谷直樹, 熊野宏昭, 美野田啓二, 古口高志, 田之内厚三, 金澤素, 福土審

    心身医学 41 123-123 2001年5月1日

    出版者・発行元:日本心身医学会

    DOI: 10.15064/jjpm.41.supplementII_123_2  

    ISSN:0385-0307

  202. IIG-22 筋弾性及びその左右のバランスとパーソナリティー及び心理的ストレス反応との関連(性格傾向)

    中谷直樹, 熊野宏昭, 美野田啓二, 福土審

    心身医学 40 212-212 2000年6月10日

    出版者・発行元:日本心身医学会

    DOI: 10.15064/jjpm.40.supplement_212_2  

    ISSN:0385-0307

  203. C-3 水頭症男児の帰属変容と学級適応の向上(ケーススタディ)

    富家 直明, 中谷 直樹, 熊野 宏昭, 福土 審

    日本行動療法学会大会発表論文集 (25) 172-173 1999年11月25日

    出版者・発行元:一般社団法人日本認知・行動療法学会

  204. P-42 アローバランスグラフの信頼性及び妥当性の検討(ポスター発表5)

    中谷 直樹, 熊野 宏昭, 福土 審, 美野田 啓二

    日本行動療法学会大会発表論文集 (25) 158-159 1999年11月25日

    出版者・発行元:一般社団法人日本認知・行動療法学会

  205. Tsubono Y, Tsuji I, Fujita K, Nakaya N, Hozawa A, Ohkubo T, Kuwahara A, Watanabe Y, Ogawa K, Nishino Y, Hisamichi S. Validation of walking questionnaire for population-based prospective studies in Japan: comparison with pedometer. Journal of Epidemiolo・・・

    詳細を見る 詳細を閉じる

    Tsubono Y, Tsuji I, Fujita K, Nakaya N, Hozawa A, Ohkubo T, Kuwahara A, Watanabe Y, Ogawa K, Nishino Y, Hisamichi S. Validation of walking questionnaire for population-based prospective studies in Japan: comparison with pedometer. Journal of Epidemiology, 12, 305-9, 2002.

  206. Koizumi Y, Tsubono Y, Nakaya N, Nishino Y, Shibuya D, Matsuoka H, Tsuji I. No association between green tea and the risk of gastric cancer: pooled analysis of two prospective studies in Japan. Cancer Epidemiology, Biomarkers & Prevention, 12, 472-47・・・

    詳細を見る 詳細を閉じる

    Koizumi Y, Tsubono Y, Nakaya N, Nishino Y, Shibuya D, Matsuoka H, Tsuji I. No association between green tea and the risk of gastric cancer: pooled analysis of two prospective studies in Japan. Cancer Epidemiology, Biomarkers &amp; Prevention, 12, 472-473, 2003.

  207. Tsubono Y, Nakaya N, Tsuji I. Personality and the risk of cancer (Response). Journal of the National Cancer Institute, 95, 1638, 2003.

  208. Watanabe T, Nakaya N, Kurashima K, Kuriyama S, Tsubono Y, Tsuji I. Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study. European Journal of Cancer, 40, 2109-2015, 2004.

  209. Suzuki Y, Tsubono Y, Nakaya N, Suzuki Y, Koizumi Y, Tsuji I. Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan. British Journal of Cancer, 90, 1361-1363, 2004.

  210. Koizumi Y, Tsubono Y, Nakaya N, Kuriyama S, Shibuya D, Matsuoka H, Tsuji I. Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan. International Journal of Cancer, 112, 1049-1055, 2004.

  211. Tsuji I, Nishino Y, Tsubono Y, Suzuki Y, Hozawa A, Nakaya N, Fujita K, Kuriyama S, Shibuya D, Fukao A, Hisamichi S. Follow-up and mortality profiles in the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S2-S6, 2004.

  212. Kuriyama S, Ohmori K, Miura C, Suzuki Y, Nakaya N, Fujita K, Sato Y, Tsubono Y, Tsuji I, Fukao A, Hisamichi S. Body mass index and mortality in Japan: the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S33-S38, 2004.

  213. Tsubono Y, Koizumi Y, Nakaya N, Fujita K, Takahashi H, Hozawa A, Suzuki Y, Kuriyama S, Tsuji I, Fukao A, Hisamichi S. Health practices and mortality in Japan: combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study・・・

    詳細を見る 詳細を閉じる

    Tsubono Y, Koizumi Y, Nakaya N, Fujita K, Takahashi H, Hozawa A, Suzuki Y, Kuriyama S, Tsuji I, Fukao A, Hisamichi S. Health practices and mortality in Japan: combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S39-S45, 2004.

  214. Sato Y, Tsubono Y, Nakaya N, Ogawa K, Kurashima K, Kuriyama S, Hozawa A, Nishino Y, Shibuya D, Tsuji I. Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study. Public Health and Nutrition, 8, 309-314, 2005

  215. Suzuki Y, Tsubono Y, Nakaya N, Koizumi Y, Suzuki Y, Shibuya D, Tsuji I. Green tea and the risk of colorectal cancer: pooled analysis of two prospective studies in Japan. Journal of Epidemiology, 15, 118-124, 2005.

  216. Yoshikawa E, Matsuoka Y, Yamasue H, Inagaki M, Nakano T, Akechi T, Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Kasai K, Uchitomi Y. Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer di・・・

    詳細を見る 詳細を閉じる

    Yoshikawa E, Matsuoka Y, Yamasue H, Inagaki M, Nakano T, Akechi T, Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Kasai K, Uchitomi Y. Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis. Biological Psychiatry, 59, 707-712, 2006.

  217. Kikuchi N, Ohmori K, Shimazu T, Nakaya N, Kuriyama S, Nishino Y, Tsubono Y, Tsuji I. No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study. British Journal of Cancer, 95, 371-373, 2006.

  218. Fujimori M, Kobayakawa M, Nakaya N, Nagai K, Nishiwaki Y, Inagaki K, Uchitomi Y. Psychometric properties of the Japanese version of the Quality Of Life-Cancer Survivors Instrument. Quality of Life Research, 15, 1633-1638, 2006.

  219. Niu K, Hozawa A, Kuriyama S, Ohmori-Matsuda K, Shimazu T, Nakaya N, Fujita K, Tsuji I, Nagatomi R. Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine・・・

    詳細を見る 詳細を閉じる

    Niu K, Hozawa A, Kuriyama S, Ohmori-Matsuda K, Shimazu T, Nakaya N, Fujita K, Tsuji I, Nagatomi R. Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products. American Journal of Clinical Nutrition, 84, 223-229, 2006.

  220. Kuriyama S, Ebihara S, Hozawa A, Ohmori K, Kurashima K, Nakaya N, Matsui T, Arai H, Tsubono Y, Sasaki H, Tsuji I. Dietary intakes and plasma 8-iso-prostaglandin F2alpha concentrations in community-dwelling elderly Japanese: the Tsurugaya project. In・・・

    詳細を見る 詳細を閉じる

    Kuriyama S, Ebihara S, Hozawa A, Ohmori K, Kurashima K, Nakaya N, Matsui T, Arai H, Tsubono Y, Sasaki H, Tsuji I. Dietary intakes and plasma 8-iso-prostaglandin F2alpha concentrations in community-dwelling elderly Japanese: the Tsurugaya project. International Journal of Vitamin and Nutrition Research,76, 87-94, 2006.

  221. Sato Y, Nakaya N, Kuriyama S, Nishino Y, Tsubono Y, Tsuji I. Meat consumption and risk of colorectal cancer in Japan: the Miyagi Cohort Study. European Journal of Cancer Prevention, 15, 211-218, 2006.

  222. Ogata M, Kuriyama S, Sato Y, Shimazu T, Nakaya N, Ohmori K, Hozawa A, Tsuji I. Impact of non-dietary nutrients intake on misclassification in the estimation of nutrient intake in epidemiologic study. Journal of Epidemiology, 16, 193-200, 2006.

  223. Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, Tsubono Y, Tsuji I. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA, 296, 1255-1265, 2006.

  224. Saito-Nakaya K, Nakaya N, Fujimori M, Akizuki N, Yoshikawa E, Kobayakawa M, Nagai K, Nishiwaki Y, Tsubono Y, Uchitomi Y. Marital status, social support and survival after curative resection in non-small-cell lung cancer. Cancer Science, 97, 206-213,・・・

    詳細を見る 詳細を閉じる

    Saito-Nakaya K, Nakaya N, Fujimori M, Akizuki N, Yoshikawa E, Kobayakawa M, Nagai K, Nishiwaki Y, Tsubono Y, Uchitomi Y. Marital status, social support and survival after curative resection in non-small-cell lung cancer. Cancer Science, 97, 206-213, 2006.

  225. Miyamoto A, Kuriyama S, Nishino Y, Tsubono Y, Nakaya N, Ohmori K, Kurashima K, Shibuya D, Tsuji I. Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: a population-based cohort study. Preventive Medicine, 44・・・

    詳細を見る 詳細を閉じる

    Miyamoto A, Kuriyama S, Nishino Y, Tsubono Y, Nakaya N, Ohmori K, Kurashima K, Shibuya D, Tsuji I. Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: a population-based cohort study. Preventive Medicine, 44, 12-19, 2007.

  226. Awata S, Bech P, Koizumi Y, Seki T, Kuriyama S, Hozawa A, Ohmori K, Nakaya N, Matsuoka H, Tsuji I. Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community resident・・・

    詳細を見る 詳細を閉じる

    Awata S, Bech P, Koizumi Y, Seki T, Kuriyama S, Hozawa A, Ohmori K, Nakaya N, Matsuoka H, Tsuji I. Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community residents. International Journal of Psychogeriatrics, 19, 77-88, 2007.

  227. Akhter M, Kuriyama S, Nakaya N, Shimazu T, Ohmori K, Nishino Y, Tsubono Y, Fukao A, Tsuji I. Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: the Miyagi Cohort Study. European Journal of Can・・・

    詳細を見る 詳細を閉じる

    Akhter M, Kuriyama S, Nakaya N, Shimazu T, Ohmori K, Nishino Y, Tsubono Y, Fukao A, Tsuji I. Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: the Miyagi Cohort Study. European Journal of Cancer, 43, 383-390, 2007.

  228. Naganuma T, Kuriyama S, Akhter M, Kakizaki M, Nakaya N, Matsuda-Ohmori K, Shimazu T, Fukao A, Tsuji I. Coffee consumption and the risk of colorectal cancer: a prospective cohort study in Japan. International Journal of Cancer, 120, 1542-1547, 2007.

  229. Ohmori-Matsuda K, Kuriyama S, Hozawa A, Nakaya N, Shimazu T, Tsuji I. The joint impact of cardiovascular risk factors upon medical costs. Preventive Medicine, 44, 349-355, 2007.

  230. Akhter M, Nishino Y, Nakaya N, Kurashima K, Sato Y, Kuriyama S, Tsubono Y, Tsuji I. Cigarette smoking and the risk of colorectal cancer among men: a prospective study in Japan. European Journal of Cancer Prevention, 16, 102-107, 2007.

  231. Iijima K, Koike T, Abe Y, Inomata Y, Sekine H, Imatani A, Nakaya N, Ohara S, Shimosegawa T. Extensive gastric atrophy: an increased risk factor for superficial esophageal squamous cell carcinoma in Japan. American Journal of Gastroenterology, 102, 1・・・

    詳細を見る 詳細を閉じる

    Iijima K, Koike T, Abe Y, Inomata Y, Sekine H, Imatani A, Nakaya N, Ohara S, Shimosegawa T. Extensive gastric atrophy: an increased risk factor for superficial esophageal squamous cell carcinoma in Japan. American Journal of Gastroenterology, 102, 1603-1609, 2007.

  232. Shimazu T, Kuriyama S, Hozawa A, Ohmori K, Sato Y, Nakaya N, Nishino Y, Tsubono Y, Tsuji I. Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study. International Journal of Epidemiology, 36, 600-609, 2007.

  233. Hamaguchi T, Okamura H, Nakaya N, Abe K, Abe Y, Umezawa S, Kurihara M, Nakaya K, Yomiya K, Uchitomi Y. Survey of the current status of cancer rehabilitation in Japan. Disability and Rehabilitation,30,559-564,2008.

  234. Takahashi H, Kuriyama S, Tsubono Y, Nakaya N, Fujita K, Nishino Y, Shibuya D, Tsuji I. Time spent walking and risk of colorectal cancer in Japan: The Miyagi Cohort Study. European Journal of Cancer Prevention, 16, 403-408, 2007.

  235. Kakizaki M, Kuriyama S, Sato Y, Shimazu T, Matsuda-Ohmori K, Nakaya N, Fukao A, Fukudo S, Tsuji I. Personality and body mass index: A cross-sectional analysis from the Miyagi Cohort Study. Journal of Psychosomatic Research, 64, 71-80, 2008.

  236. Saito-Nakaya K, Nakaya N, Akechi T, Inagaki M, Asai M, Goto K, Nagai K, Nishiwaki Y, Tsugane S, Fukudo S, Uchitomi Y. Marital status and non-small cell lung cancer survival: the Lung Cancer Database Project in Japan. Psychooncology, 17, 869-876.

  237. Li XM, Li J, Tsuji I, Nakaya N, Nishino Y, Zhao XJ.Mass screening-based case-control study of diet and prostate cancer in Changchun, China. Asian Journal of Andrology,10,551-560,2008.

  238. Niu K, Hozawa A, Awata S, Guo H, Kuriyama S, Seki T, Ohmori-Matsuda K, Nakaya N, Ebihara S, Wang Y, Tsuji I, Nagatomi R. Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: a population-based, cro・・・

    詳細を見る 詳細を閉じる

    Niu K, Hozawa A, Awata S, Guo H, Kuriyama S, Seki T, Ohmori-Matsuda K, Nakaya N, Ebihara S, Wang Y, Tsuji I, Nagatomi R. Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: a population-based, cross-sectional analysis. Hypertension Research,31,409-416,2008.

  239. Koizumi T, Nakaya N, Okamura C, Sato Y, Shimazu T, Nagase S, Niikura H, Kuriyama S, Tase T, Ito K, Tsubono Y, Okamura K, Yaegashi N, Tsuji I. Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma. Eur J Cancer・・・

    詳細を見る 詳細を閉じる

    Koizumi T, Nakaya N, Okamura C, Sato Y, Shimazu T, Nagase S, Niikura H, Kuriyama S, Tase T, Ito K, Tsubono Y, Okamura K, Yaegashi N, Tsuji I. Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma. Eur J Cancer Prev 2008;17:358-63.

  240. Niu K, Hozawa A, Guo H, Kuriyama S, Ebihara S, Yang G, Ohmori-Matsuda K, Nakaya N, Takahashi H, Fujita K, Wen S, Arai H, Tsuji I, Nagatomi R. Serum C-Reactive Protein Even at Very Low (<1.0 mg/l) Concentration Is Associated with Physical Performance in・・・

    詳細を見る 詳細を閉じる

    Niu K, Hozawa A, Guo H, Kuriyama S, Ebihara S, Yang G, Ohmori-Matsuda K, Nakaya N, Takahashi H, Fujita K, Wen S, Arai H, Tsuji I, Nagatomi R. Serum C-Reactive Protein Even at Very Low (&lt;1.0 mg/l) Concentration Is Associated with Physical Performance in a Community-Based Elderly Population Aged 70 Years and Over. Gerontology, 54, 260-267, 2008.

  241. Kakizaki M, Inoue K, Kuriyama S, Sone T, Matsuda-Ohmori K, Nakaya N, Fukudo S, Tsuji I. Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study. British Journal of Cancer, 99, 176-178, 2008.

  242. Kuriyama S,Shimazu T,Hozawa A,Kure S,Kurokawa N,Kakizaki M,Sone T,Matsuda-Ohmori K,Nakaya N,Satoh H,Tsuji I. No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults. Me・・・

    詳細を見る 詳細を閉じる

    Kuriyama S,Shimazu T,Hozawa A,Kure S,Kurokawa N,Kakizaki M,Sone T,Matsuda-Ohmori K,Nakaya N,Satoh H,Tsuji I. No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults. Metabolism, 57, 1570-1575, 2008.

  243. Li Q,Kakizaki M,Kuriyama S, Sone T, Yan H, Nakaya N, Mastuda-Ohmori K, Tsuji I. Green Tea Consumption and the Risk of Lung Cancer: The Ohsaki Study. British Journal of Cancer, 99, 1179-1184, 2008.

  244. Kikuchi N, Ohmori-Matsuda K, Shimazu T, Sone T, Kakizaki M, Nakaya N, Kuriyama S, Tsuji I.Pain and Risk of Completed Suicide in Japanese Men: A Population-Based Cohort Study in Japan (Ohsaki Cohort Study).Journal of Pain Symptom and Management (in pres・・・

    詳細を見る 詳細を閉じる

    Kikuchi N, Ohmori-Matsuda K, Shimazu T, Sone T, Kakizaki M, Nakaya N, Kuriyama S, Tsuji I.Pain and Risk of Completed Suicide in Japanese Men: A Population-Based Cohort Study in Japan (Ohsaki Cohort Study).Journal of Pain Symptom and Management (in press).

  245. Kakizaki M, Kuriyama S, Sone T, Ohmori-Matsuda K, Hozawa A, Nakaya N, Fukudo S, Tsuji I. Sleep Duration and the Risk of Breast Cancer: The Ohsaki Cohort Study. British Journal of Cancer, 99, 1502-1505, 2008.

  246. Li Q, Kakizaki M, Kuriyama S, Sone T, Yan H, Nakaya N, Mastuda-Ohmori K, Tsuji I.Green tea consumption and lung cancer risk: the Ohsaki study.British Journal of Cancer, 99, 1179-1184, 2008.

  247. Arai S, Nakaya N, Kakizaki M, Ohmori K, Shimazu T, Kuriyama S, Fukao A, Tsuji I. Personality and Gastric Cancer Screening Attendance: A Cross-Sectional Analysis from the Miyagi Cohort Study. Journal of Epidemiology (In press).

  248. Naganuma T, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji I.Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan: the miyagi cohort study. American Journal of Epidemiology, 168, 14・・・

    詳細を見る 詳細を閉じる

    Naganuma T, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji I.Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan: the miyagi cohort study. American Journal of Epidemiology, 168, 1425-1432, 2008.

  249. Kakuta Y, Nakaya N, Nagase S, Fujita M, Koizumi T, Okamura C, Niikura H. Ohmori K, Kuriyama S, Tase T, Ito K, Minami Y, Yaegashi N, Tsuji I. Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Cau・・・

    詳細を見る 詳細を閉じる

    Kakuta Y, Nakaya N, Nagase S, Fujita M, Koizumi T, Okamura C, Niikura H. Ohmori K, Kuriyama S, Tase T, Ito K, Minami Y, Yaegashi N, Tsuji I. Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Causes Control (in press).

  250. 中谷直樹, 大森 芳, 鈴木寿則, 寳澤 篤, 栗山進一, 坪野吉孝, 辻 一郎. がん検診の実施状況に関する市区町村実態調査. 日本公衆衛生雑誌, 51, 530-539, 2004.

  251. 濱口豊太, 中谷直樹、奈良進弘、赤松郁夫: 長期加療中脳卒中患者の心理的ストレス状況と筋弾性との関連. 新潟医療福祉大学紀要, 3, 77-82, 2003.

  252. 小泉弥生, 粟田主一, 関 徹, 中谷直樹, 栗山進一, 鈴木寿則, 大森 芳, 寳澤 篤, 海老原 覚, 荒井啓行, 辻 一郎. 都市在住の高齢者におけるソーシャル・サポートと抑うつ症状の関連性. 日本老年医学会雑誌, 41, 426-433, 2004.

  253. 佐藤文美, 島津太一, 栗山進一, 大森 芳,中谷直樹, 辻 一郎,荒井陽一. 日本における魚摂取と前立腺癌罹患に関する前向きコホート研究. 日本泌尿器科学会雑誌, 99, 14-21, 2008.

    DOI: 10.5980/jpnjurol1989.99.14  

  254. Higashiguchi M, Nakaya N, Ohmori K, Shimazu T, Sone T, Hozawa A, Kuriyama S, Tsuji I.Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project.Nippon Koshu Eisei Zasshi 2008;55:433-9. (Jap・・・

    詳細を見る 詳細を閉じる

    Higashiguchi M, Nakaya N, Ohmori K, Shimazu T, Sone T, Hozawa A, Kuriyama S, Tsuji I.Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project.Nippon Koshu Eisei Zasshi 2008;55:433-9. (Japanese)

  255. Nakaya N, Tsubono Y, Hosokawa T, Nishino Y, Ohkubo T, Hozawa A, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Personality and the risk of cancer. Journal of the National Cancer Institute, 95, 799-805, 2003.

  256. Nakaya N, Kurashima K, Yamaguchi J, Ohkubo T, Nishino Y, Tsubono Y, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Alcohol consumption and mortality in Japan: the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S18-S25, 2004.

  257. Nakaya N, Kumano H, Minoda K, Kanazawa M, Fukudo S. Laterality and imbalance of muscle stiffness related to personality. Behavioral Medicine, 30, 5-9, 2004.

  258. Nakaya N, Kumano H, Minoda K, Koguchi T, Tanouchi K, Kanazawa M, Fukudo S. Psychological effects of the muscle relaxation on juvenile delinquents: Preliminary Study. International Journal of Behavioral Medicine, 11, 176-180, 2004.

  259. Nakaya N, Tsubono Y, Hosokawa T, Hozawa A, Fukudo S, Tsuji I. Personality and the risk of ischemic heart disease and stroke. Clinical and Experimental Hypertension, 2&3, 301-309, 2005.

  260. Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I. Alcohol consumption and the risk of cancer in Japanese men: The Miyagi Cohort Study. European Journal of Cancer Prevention, 14, 169-174, 2005.

  261. Nakaya N, Fukudo S, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Shimizu K, Nagai K, Nishiwaki Y, Uchitomi Y. Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival. Acta Oncologica, 44, 399-4・・・

    詳細を見る 詳細を閉じる

    Nakaya N, Fukudo S, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Shimizu K, Nagai K, Nishiwaki Y, Uchitomi Y. Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival. Acta Oncologica, 44, 399-405, 2005.

  262. Nakaya N, Tsubono Y, Nishino Y, Hosokawa T, Fukudo S, Shibuya D, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Saito-Nakaya, K, Uchitomi Y, Tsuji I. Personality and survival from cancer. British Journal of Cancer, 92, 2089-2094, 2005.

  263. Nakaya N, Goto K, Saito-Nakaya K, Inagaki M, Otani T, Akechi T, Nagai K, Hojo F, Uchitomi Y, Tsugane S, Nishiwaki Y. The Lung Cancer Database Project at the National Cancer Center, Japan. Japanese Journal of Clinical Oncology, 36, 280-284, 2006.

  264. Nakaya N, Saito-Nakaya K, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Nagai K, Nishiwaki Y, Fukudo S, Tsubono Y, Uchitomi Y. Depression and survival from non-small cell lung cancer after curative resection: preliminary study. Cancer Science, 97, ・・・

    詳細を見る 詳細を閉じる

    Nakaya N, Saito-Nakaya K, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Nagai K, Nishiwaki Y, Fukudo S, Tsubono Y, Uchitomi Y. Depression and survival from non-small cell lung cancer after curative resection: preliminary study. Cancer Science, 97, 199-205, 2006.

  265. Nakaya N, Hansen PE, Schapiro IR, Eplov LF, Saito-Nakaya K, Uchitomi Y, Johansen C. Personality traits and Cancer Survival: A Danish cohort study. British Journal of Cancer, 95, 146-152, 2006.

  266. Nakaya N, Kikuchi N, Shimazu T, Ohmori K, Kakizaki M, Sone T, Awata S, Kuriyama S, Tsuji I. Alcohol Consumption and Suicide Mortality among Japanese Men: The Ohsaki Study. Alcohol, 41, 503-510, 2007.

  267. Nakaya N, Saito-Nakaya K, Akechi T, Kuriyama S, Inagaki M, Kikuchi N, Nagai K, Tsugane S, Nishiwaki Y, Tsuji I, Uchitomi Y. Negative Psychological Aspects and Survival in Lung Cancer Patients. Psycho-Oncology, 17, 466-73, 2008.

︎全件表示 ︎最初の5件までを表示

書籍等出版物 19

  1. 中谷直樹. 心理社会的要因とがん発症・生存に関する最新データ. 緩和ケア, 23, pp217, 2013.(総説)

    中谷 直樹

  2. Daisuke Nishi, Yuichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka. PTSD and the Attenuating Effects of Fish Oils: Results of Supplementation After the 2011 Great East Japan Earthquake (Chapter 16).

  3. 中谷直樹. 飲酒と自殺に関する前向きコホート研究ー大崎コホート研究ー.日本アルコール関連問題学会雑誌 13, 32-34, 2011

  4. 中谷直樹. 罹患・生存と心理社会的問題. 内富庸介、小川朝生 (編). 臨床精神腫瘍学. 医学書院, 東京, pp25-36, 2011

  5. 中谷直樹, 福土 審. 各臓器別にみた心身症: ②消化器-胃・十二指腸潰瘍. 久保千春 (編). 心身医療実践マニュアル-知っておきたい臨床医の基本. 文光堂, 東京, pp200-206, 2003. (著書)

  6. 中谷直樹, 福土 審. 各臓器別にみた心身症: ②消化器-過敏性腸症候群. 久保千春 (編). 心身医療実践マニュアル-知っておきたい臨床医の基本. 文光堂, 東京, pp195-199, 2003. (著書)

  7. 中谷直樹, 福土 審. サイコオンコロジー: がんの病前性格. 保坂 隆 (編). 現代のエスプリ. 至文堂, 東京, pp53-62, 2003. (総説)

  8. 中谷直樹, 坪野吉孝. がんの病前性格. 医学のあゆみ, 206, pp878-879, 2003.(総説)

  9. 中谷直樹, 坪野吉孝, 細川 徹, 西野善一, 大久保孝義, 寳澤 篤, 渋谷大助, 福土 審, 深尾 彰, 辻 一郎, 久道 茂. パーソナリティとがん罹患に関する前向きコホート研究. 心身医学, 44, pp471-477, 2004.(総説)

  10. 中谷直樹, 内富庸介. Mebio Oncology, 2, pp116-117, 2005. (Kissane DW, et al. Effect of cognitive-existential group therapy on survival in early-stage breast cancer. Journal of Clinical Oncology, 22, 4255-5260, 2004.).(解説)

  11. 中谷直樹, 清水 研, 大庭 章, 内富庸介, 坪野吉孝. サイコオンコロジーと心身医療-がんと疫学-. 心療内科, 9, pp95-100, 2005.(総説)

  12. 中谷直樹, 辻 一郎:わが国におけるがん検診の現状と問題点-地域格差.クリニカルプラクティス, 25, pp245-249, 2006.(総説)

  13. 中谷直樹. 疾病誘発パーソナリティ.日本応用心理学会 (編): 応用心理学事典, 丸善, 東京, pp270-271, 2007.(著書)

  14. 中谷直樹. 心理社会的要因とがん罹患/生存 -パーソナリティを中心として-. 腫瘍内科, 1, pp383-388, 2007.(総説)

  15. 中谷直樹, 内富庸介. ストレスとがん罹患に関する疫学研究. ストレス科学研究,23,pp1-7,2008.(総説)

  16. 中谷直樹,中谷久美. がん患者のサバイバーシップ;社会的問題(退職・未就労リスク及び離婚リスク). 腫瘍内科, 5, 122-130, 2010.(総説)

  17. 中谷直樹, 中谷久美. 心理社会的要因とがん罹患/生存. 大西秀樹 (編). 専門医のための精神科臨床リュミエール24, サイコオンコロジー. 中山書店, 東京,pp26-37.(著書)

  18. 中谷直樹、中谷久美、中村好一、辻 一郎.デンマークにおける保健医療データベースに関する調査研究.公衆衛生,75(2),医学書院,pp160-163, 2011.

  19. 中谷直樹. 心理的要因ががん発症・がん予後に与える影響. がん医療に携わるすべての医師のための心のケアガイド.真興交易㈱医書出版部,東京.pp211-218,2011.(著書)

︎全件表示 ︎最初の5件までを表示

講演・口頭発表等 50

  1. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要. 中谷直樹、小暮真奈、畑中里衣子、菅野郁美、中谷久美、小原 拓、中村智洋、宇留野 晃、布施昇男、泉 陽子、丹野高三、辻 一郎、栗山進一、呉 繁夫、寳澤 篤. 第80回日本公衆衛生学会総会. オンライン開催, 12月, 2021年.

  2. 中谷直樹.東北メディカル・メガバンク計画・地域住民コホート調査:健康行動学的側面の結果及び今後の展開.日本行動医学会学術総会,オンライン開催,11月,2021(シンポジウム)

  3. Partners’ ongoing treatment for chronic disease and the risk of psychological distress after the Great East Japan Earthquake.Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita. 21st World Congress of

  4. 中谷直樹、成田 暁、中村智洋、土屋菜歩、小暮真奈、丹野高三、坂田清美、菊谷昌浩、 高井貴子、菅原準一、栗山進一、辻 一郎、呉 繁夫、寳澤 篤.性・年齢階級別にみた東日本大震災後の平均歩数:地域住民コホート調査.第66回東北公衆衛生学会、福島市、7月、2017年(一般口演)

  5. 中谷直樹、中村智洋、土屋菜歩、成田暁、小暮真奈、丹野高三、 佐々木亮平、高梨信之、坂田清美、富田博秋、菊谷昌浩、菅原準一、 栗山進一、辻一郎、呉繁夫、寳澤篤.東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較.第27回日本疫学会総会,甲府,1月,2017年(ポスター発表).

  6. 中谷直樹、中村智洋、土屋菜歩、成田 暁、小暮真奈、丹野高三、佐々木亮平、坂田清美、富田博秋、菊谷昌浩、菅原準一、栗山進一、辻 一郎、呉 繁夫、寳澤 篤. 沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク.第75回日本公衆衛生学会、大阪市、10月、2016年(一般口演)

  7. 中谷直樹、中村智洋、土屋菜歩、成田 暁、辻 一郎、寳澤 篤、富田博秋. 東日本大震災1年後沿岸部被災地における心理的苦痛と高血圧治療中断関連:七ヶ浜健康増進プロジェクト. 第52回日本循環器病予防学会、さいたま市、6月、2016年(一般口演)

  8. 中谷直樹、中村智洋、土屋菜歩、成田 暁、辻 一郎、寳澤 篤、富田博秋.震災1年後の将来の住居の見通しと心理的苦痛リスクの関連.第65回東北公衆衛生学会, 山形市,7月,2016年(一般口演)

  9. 中谷直樹.東日本大震災の心身への影響:東北メディカル・メガバンク計画.第57回日本心身医学会総会ならびに学術講演会、仙台市、6月、2016年(市民公開講座)

  10. 中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋. 東日本大震災の被災地における慢性疾患治療と就労の関連:七ヶ浜健康増進プロジェクト.日本公衆衛生学会総会、宇都宮市、11月、2014年(口頭発表)

  11. 中谷直樹、中村智洋、土屋菜歩、成田 暁、菊谷昌浩、小原 拓、清元秀泰、栗山進一、辻 一郎、呉 繁夫、寳澤 篤、丹野高三、佐々木亮平、坂田清美.震災関連要因と慢性疾患の治療中断の関連:地域住民コホート調査.第26回日本疫学会学術総会、米子市、1月、2016年(ポスター発表)

  12. 中谷直樹、中村智洋、土屋菜歩、成田 暁、小暮真奈、 中谷 純、峯岸直子、布施昇男、鈴木洋一、菅原準一、菊谷昌浩、富田博秋、清元秀泰、栗山進一、辻 一郎、呉 繁夫、山本雅之、寳澤 篤.東日本大震災後の宮城県沿岸部における治療中断 東北メディカル・メガバンク事業:地域住民コホート調査.宮城県公衆衛生学会,仙台,6月,2015(口頭発表)

  13. Nakaya N, Nakamura T, Tsuchiya N, Kogure M, Tanno K, Sasaki R, Sakata K, Nakaya J, Minegishi N, Fuse N, Suzuki Y, Sugawara J, Kikiuya M, Tomita H, Kiyomoto H, Kuriyama S, Tsuji I, Yaegashi N, Yamamoto Y, Hozawa A. Comparison of the mental issues of co

  14. 中谷直樹.埼玉がんリハビリテーション研究会.心理社会的要因とがんの罹患/生存,大宮,2月,2015(基調講演).

  15. 中谷 直樹、土屋 菜歩、中谷 久美、成田 暁、平田 匠、中村 智洋、小暮 真奈 、小原拓、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤 篤. 配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査. 第29回日本疫学会学術総会、東京、1月、2019(ポスター発表).

  16. 中谷直樹、中村智洋、辻 一郎、富田博秋.慢性疾患治療者の心理的苦痛に関する研究:七ヶ浜健康増進プロジェクト.日本疫学会総会,仙台,1月,2014(ポスター発表)

  17. 中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋. 慢性疾患治療者の心理的苦痛に関する研究:七ヶ浜健康増進プロジェクト. 日本公衆衛生学会総会, 津, 10月, 2013(口頭発表)

  18. 中谷直樹, 心理社会的因子とがん発症・がん予後に関する疫学研究及び今後の展開. 日本サイコオンコロジー学会総会, 9月, 2013 (シンポジウム)

  19. 中谷直樹.がんに影響を及ぼす心理社会的要因の検討.日本疫学会総会,大阪,1月,2013 (奨励賞受賞講演).

  20. 中谷直樹, 菊谷昌浩, 中谷純, 清元秀泰, 菅原準一, 富田博秋, 長神風二, 大隅典子, 栗山進一, 辻 一郎, 寳澤 篤. 東北メディカル・メガバンク事業:山元町における住民意識調査. 日本疫学会総会,大阪,1月,2013 (ポスター発表).

  21. 中谷直樹、中村智洋、土屋菜歩、平田 匠、成田 暁、小暮真奈、後岡広太郎、丹野高三、坂田清美、小原 拓、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤 篤.東日本大震災の被災地住民における平均歩数の変化:地域住民コホート調査.第77回日本公衆衛生学会総会、郡山市、10月、2018年(口頭発表)

  22. 中谷直樹、根本晴美、Carine J. Yi、佐藤文子、新宮古都美、庄子朋香、佐藤翔輔、土屋菜歩、中村智洋、成田 暁、小暮真奈、菅原由美、兪 志前、Nicole Gunawansa、栗山進一、村尾 修、佐藤 健、今村文彦、辻 一郎、寳澤 篤、富田博秋.東日本大震災による津波避難訓練の有効性.第54回宮城県公衆衛生学会学術総会、仙台、7月、2018年(口頭発表).

  23. 中谷直樹、成田 暁、中村智洋、土屋菜歩、小暮真奈、丹野高三、坂田清美、菊谷昌浩、高井貴子、菅原準一、栗山進一、辻 一郎、呉 繁夫、寳澤 篤.東日本大震災の被災者における高い平均歩数と関連する要因:地域住民コホート調査.第28回日本疫学会学術総会、福島市、2月、2018年(ポスター発表)

  24. 中谷直樹、成田 暁、中村智洋、土屋菜歩、小暮真奈、 丹野高三、坂田清美、菊谷昌浩、高井貴子、菅原準一、栗山進一、辻 一郎、呉 繁夫、寳澤 篤.地域住民コホート調査における 家屋の被害の程度と平均歩数の関連.第76回日本公衆衛生学会総会、鹿児島市、10月、2017年(口頭発表)

  25. 中谷直樹, 中谷久美, Bidstrup PE, Dalton SO, Frederiksen K, Steding-Jessen M, 内富庸介, Johansen C. 乳がん患者における男性パートナーのうつ病リスク. 日本疫学会総会,東京,1月,2012 (ポスター発表).

  26. Nakaya N, Kumano H, Minoda K, Fukudo S: Imbalance of Muscle Tension Closely Relates to Personality and Stress Response. The 6th International Congress of Behavioral Medicine, Brisbane, November, 2000.

  27. Nakaya N, Saito K, Kurashima K, Hozawa A, Kanazawa M, Fukudo S, Tsuji I. Increased Risk of Irritable Bowel Syndrome in Depressive Individuals in Elderly Population. The 104th American Gastroenterological Association, Orlando, May, 2003.

  28. Nakaya N, Tsubono Y, Hosokawa T, Nishino Y, Ohkubo T, Hozawa A, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Personality and the risk of ischemic heart disease and cerebrovascular disease. The 5th Japanese Annual Conference on Chronocardiology a・・・

    詳細を見る 詳細を閉じる

    Nakaya N, Tsubono Y, Hosokawa T, Nishino Y, Ohkubo T, Hozawa A, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Personality and the risk of ischemic heart disease and cerebrovascular disease. The 5th Japanese Annual Conference on Chronocardiology and Hypertension, Sapporo, September, 2003.

  29. Nakaya N, Tsubono Y, Hosokawa T, Fukudo S, Tsuji I. Personality and the risk of cancer. The 7th World Congress of Psycho-Oncology, Copenhagen, August, 2004.

  30. Nakaya N, Tsubono Y, Nishino Y, Hosokawa T, Fukudo S, Shibuya D, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Uchitomi Y, Tsuji I. Personality and survival from cancer. The 18th World Congress on Psychosomatic Medicine, Kobe, August, 2005.

  31. Nakaya N, Saito-Nakaya K, Bidstrup PE, Dalton SO, Frederiksen K, Steding-Jessen M, Uchitomi Y, Johansen C. Risk of affective disorders after spouse's breast cancer diagnosis. The 11th World Congress on Psycho-Oncology, Vienna, June, 2009.

  32. 中谷直樹, 熊野宏昭, 美野田啓二. アローバランスグラフの信頼性及び心理的質問票との関連性について. 第40回日本心身医学会総会,弘前,6月,1999.

  33. 中谷直樹, 熊野宏昭, 美野田啓二, 福士審: 筋骨格系の歪みとパーソナリティ及び心理的ストレス反応との関連の検討. 日本心身医学会東北地方会,盛岡,9月,1999.

  34. 中谷直樹, 熊野宏昭, 美野田啓二, 福土 審. アローバランスグラフの信頼性及び妥当性の検討.日本行動療法学会第25回大会,10月,東京,1999.

  35. 中谷直樹, 熊野宏昭, 美野田啓二, 福土 審. 筋緊張と心理面との関連―左右差及び局所の状態の重要性―. 日本心身医学会東北地方会,仙台,3月,2000.

  36. 中谷直樹, 熊野宏昭, 美野田啓二, 福土 審. 筋弾性及びその左右のバランスとパーソナリティ及び心理的ストレス反応との関連,日本心身医学会総会, 東京, 6月, 2000.

  37. 中谷直樹, 熊野宏昭, 美野田啓二, 田之内厚三, 福土 審. 少年院入院者に対するリラクセーション効果. 麻布大学環境科学研究会,神奈川,9月,2000.

  38. 中谷直樹, 熊野宏昭, 美野田啓二, 古口高志, 田之内厚三, 金澤 素, 福土 審. 少年院入院者に対するリラクセーションによる心理的変化,日本心身医学会総会,鹿児島,5月,2001.

  39. 中谷直樹, 坪野吉孝, 西野善一, 辻 一郎, 渋谷大助, 福土 審, 久道 茂. アルコールとがん罹患に関する前向きコホート研究,日本疫学会総会,東京,1月,2002.

  40. 中谷直樹, 坪野吉孝, 西野善一, 辻 一郎, 渋谷大助, 福土 審, 久道 茂. パーソナリティとがん罹患に関する前向きコホート研究,日本心身医学会総会,東京,5月,2002.

  41. 中谷直樹, 坪野吉孝, 西野善一, 辻 一郎, 渋谷大助, 福土 審, 久道 茂. 飲酒と全死因死亡に関する前向きコホート研究,東北公衆衛生学会,青森,8月,2002.

  42. 中谷直樹, 坪野吉孝, 西野善一, 辻 一郎, 渋谷大助,福土 審, 久道 茂. パーソナリティと虚血性心疾患及び脳血管疾患に関する前向きコホート研究,日本疫学会総会,福岡,1月,2003.

  43. 中谷直樹, 坪野吉孝, 西野善一, 辻 一郎, 渋谷大助, 福土 審, 久道 茂. パーソナリティと虚血性心疾患及び脳血管疾患に関する前向きコホート研究,日本心身医学会東北地方会,仙台,2月,2003.

  44. 中谷直樹, 藤田和樹, 寳澤 篤, 小泉弥生, 大森 芳, 倉嶋佳誉子, 粟田主一, 福土 審, 辻 一郎. 高齢者における過敏性腸症候群及び機能性消化管障害の抑うつ症状とQuality of Life,日本老年精神医学会,名古屋,6月,2003.

  45. 中谷直樹, 坪野吉孝, 西野善一, 辻 一郎, 渋谷大助, 福土 審, 久道 茂. パーソナリティとがん罹患に関する前向きコホート研究. 日本心身医学会総会,沖縄,5月,2003. (シンポジウム)

  46. 中谷直樹, 大森 芳, 鈴木寿則, 寳澤 篤, 栗山進一, 坪野吉孝, 辻 一郎. がん検診の実施状況に関する市区町村実態調査,日本疫学会総会,山形,1月,2004.

  47. 中谷直樹, 坪野吉孝, 西野善一, 細川 徹, 福土 審, 渋谷大助, 秋月伸哉, 吉川栄省, 小早川誠, 藤森麻衣子, 内富庸介, 辻 一郎. パーソナリティとがん予後に関する前向きコホート研究, 東北公衆衛生学会,盛岡,7月,2006.

  48. 中谷直樹, 菊地信孝, 島津太一, 大森 芳, 柿崎真沙子, 曽根稔雅, 粟田主一, 栗山進一, 辻 一郎. 飲酒と自殺に関する前向きコホート研究ー大崎コホート研究ー.日本疫学会総会,広島,1月,2007.

  49. 中谷直樹, 中谷久美, 明智龍男, 栗山進一, 稲垣正俊, 菊地信孝, 永井完治, 津金昌一郎, 西脇 裕, 辻 一郎, 内富庸介. 肺がん患者の否定的な心理状態と予後に関する前向きコホート研究. 日本疫学会総会,東京,1月,2008.

  50. 中谷直樹, 菊地信孝, 島津太一, 大森 芳, 柿崎真沙子, 曽根稔雅, 粟田主一, 栗山進一, 辻 一郎. 飲酒と自殺に関する前向きコホート研究ー大崎コホート研究ー.日本アルコール関連問題学会,神戸,7月,2010. (シンポジウム)

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 26

  1. 医療アクセスに障害を抱える人の、がん医療格差をモニタリングするための基盤研究

    稲垣 正俊, 藤原 雅樹, 中谷 直樹, 河村 敏彦

    2023年4月1日 ~ 2027年3月31日

  2. 行政データを利活用して精神障害者のがん検診受診格差を地域単位で明らかにする研究

    藤原 雅樹, 稲垣 正俊, 中谷 直樹

    2023年4月1日 ~ 2027年3月31日

  3. 社会的ケアを要する高齢者の在宅生活維持に資するQOL規定因子の実証的解明

    中村 裕美, 森山 葉子, 白岩 健, 森川 美絵, 京極 真, 中谷 直樹

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (C)

    研究機関:Saitama Prefectural University

    2020年4月1日 ~ 2024年3月31日

    詳細を見る 詳細を閉じる

    2021(令和3)年度には、3つのプロジェクトを遂行してきた。1つ目は、社会的ケア関連QoL尺度のイラスト版(The Adult Social care Outcomes Toolkit-Easy Read version)日本語版の構築であった。この版は、文字情報のみの質問紙という手段で調査することに限界のある 認知や言語表出に問題を抱える人々を、評価の主体に組み込む仕組みである。このイラスト版を、日本人の審美眼に叶うようイラストレーターを雇用し、オリジナルのイラストを起こしてきた。原版開発チームとの協議により、2021年度はそのイラストが確定できた。 2つ目のプロジェクトは、介護保険を利用する家族を支援する介護者(ケアラー)版質問紙(the Adult Social Care Outcomes Toolkit for Carer)の日本語版の信頼性と妥当性を検証し、国際学術誌で公刊することであった。 3つ目のプロジェクトは、介護保険を利用しつつ在宅生活を営む人と、その家族介護者100組を対象とした、前向きコホート研究である。これまでに我々が開発してきた質問紙(要介護者版と家族介護者版)を用いて、訪問リハビリテーションの機会を捉えて、ベースラインと、6カ月のデータ取集を行ってきた。上記質問紙に加えて、客観的指標として、握力、認知機能、日常生活自立度、活動量を測定してきた。2021年度には、ベースライン42ペア、6カ月地点で2ペアのデータを取得できている。このプロジェクトでは100ペアを1年間追跡することとしている。

  4. 大規模公的データバンクを利用した配偶者ペアの生活習慣・健康指標の一致性と介入展開

    中谷 直樹, 土屋 菜歩

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (C)

    2020年4月1日 ~ 2023年3月31日

    詳細を見る 詳細を閉じる

    これまで申請者(中谷)は、5,000を超える配偶者ペアの大規模データベースを用い、配偶者同士の生活習慣(喫煙、飲酒、身体活動)が統計学的に有意に一致したことを報告した。 本研究では、研究の新しい視点として、以下の2点を解明する;① 男女のランダムペアと比較しても、配偶者同士の生活習慣の一致性が高いのか?② 片方の配偶者が生活習慣を修正した時、もう片方の配偶者も同様に修正するのか?この2点を解明することで、配偶者同士の環境要因の重要性が明らかになり、また配偶者双方に向けた効率的・効果的な生活習慣の変容プログラムの開発を試みる。①については、2021年度中にデータセット作成、データ分析、論文化まで終了し、現在論文投稿中である。結果としては、配偶者同士と比べてランダム男女ペア(夫婦と同じ年齢のペア)では男女ペアの相関が極めて低く、オッズ比も低値を示した。

  5. 大規模コホート調査における配偶者のがん既往がパートナーに及ぼす健康影響

    中谷 直樹

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (C)

    2017年4月1日 ~ 2021年3月31日

    詳細を見る 詳細を閉じる

    本研究では一般地域住民を対象とした横断研究デザインにより、配偶者の慢性疾患既往歴(主要疾患の有無、主要疾患の個数)、主観的健康観と本人の精神・心理的状態(抑うつ症状、心理的苦痛、不眠)の関連について分析した。 その結果、配偶者の慢性疾患既往歴と本人の精神・心理的状態(抑うつ症状、心理的苦痛、不眠)の関連は示されなかった。一方、配偶者の主観的健康観「良好群」に対する「不良群」の本人の抑うつ症状有りのオッズ比は、1.2と有意に高かった(p=0.02)。この関連は、本人が女性オッズ比が1.3、また、本人の年齢64歳以下の者のオッズ比が1.3と有意な関連が示された。

  6. 要介護者の配偶者における要介護・死亡リスクに関する縦断的研究

    曽根 稔雅, 遠又 靖丈, 中谷 直樹

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (C)

    研究機関:Tohoku Fukushi University

    2016年4月1日 ~ 2020年3月31日

    詳細を見る 詳細を閉じる

    本研究の目的は、要介護者の配偶者における、健康(心理的苦痛、死亡)及び社会的側面(社会活動)への影響を明らかにすることである。また、これらの影響について要介護者の要介護度別に検討することである。 その結果、配偶者が要介護状態にない者に比べ、配偶者が要介護状態の者において、心理的苦痛が高く、社会的活動の参加頻度が低く、死亡リスクが高いことが示された。また、この結果は、要介護者の要介護度による影響を受けないことが示された。

  7. 東日本大震災後の夫婦における生活習慣と疾患の共有度および健康影響の同定

    土屋 菜歩, 中谷 直樹, 中谷 久美, 濱口 豊太

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (C)

    研究機関:Tohoku University

    2016年4月1日 ~ 2019年3月31日

    詳細を見る 詳細を閉じる

    本研究の目的は「東日本大震災後の夫婦は、生活習慣および疾患を共有しているか」を検証することである。本研究では東北メディカル・メガバンク事業地域住民コホート調査のデータを用いた。 調査参加者約50,000名の情報からデータベースを構築し、5,758組の夫婦を同定して解析を行った。夫婦の平均年齢(標準偏差)は夫で63.2(10.5)歳、妻で60.4(10.2)歳であった。塩分摂取に関する食習慣を夫婦で共有しており、年齢階級により食習慣の一致度が異なっていることが明らかになった。配偶者が生活習慣病を持たない場合に対し、配偶者がそれらを有すると疾患を有するリスクは有意に高いことが明らかになった。

  8. 破局的ストレス下の慢性疾患患者における心理的・社会的側面、生活習慣及び震災影響

    中谷 直樹, 寳澤 篤, 富田 博秋, 土屋 菜歩, 中村 智洋

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (C)

    研究機関:Tohoku University

    2014年4月1日 ~ 2017年3月31日

    詳細を見る 詳細を閉じる

    本研究では、東日本大震災のデータを用いて、慢性疾患患者(脳卒中、心筋梗塞・狭心症、腎臓病、肝臓病、がん、高血圧、糖尿病、高コレステロール血症)の心理的・社会的側面、生活習慣、震災影響を明らかにすることで、慢性疾患患者に対するサポートの必要性を検証した。結果として、慢性疾患患者は非患者に比し有意に高い心理的負担を有していることが明らかになった。慢性疾患患者は、心理的負担が高いと想定される被災者の中でもより高い心理的負担感を示しており、慢性疾患患者に対する身体的ケアのみならず心理的サポートの必要性が改めて示された。

  9. ω3系脂肪酸と集団認知行動療法によるうつ状態の増悪予防法の開発

    調 漸, 岡村 尚昌, 田山 淳, 濱崎 景, 中谷 直樹, 曽根 稔雅, 林田 雅希, 小川 豊太

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (B)

    研究機関:Nagasaki University

    2013年4月1日 ~ 2017年3月31日

    詳細を見る 詳細を閉じる

    本研究目的は,ω3系脂肪酸とpsychoeducation(PE)のコンビネーションが軽度・中程度のうつの改善に寄与するという仮説検証である。軽度・中程度のうつを有する者76名を対象としたω3系脂肪酸とPE介入群(強化介入群)とプラセボとPE介入群(通常介入群)のいずれかに無作為に割り付けた。3ヶ月の介入の結果,BDI-IIではANCOVAで有意な値は得られなかった(p=0.30, net change 0.7 (-0.7, 2.1)が,両群でBDI-IIの値が介入により有意に低下した。両群に実施したpsychoeducationの効果が強かった可能性がある。

  10. がん患者の配偶者における健康影響に関する縦断的研究

    中谷 直樹, 大庭 章, 長谷川 涼子

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Challenging Exploratory Research

    2011年 ~ 2013年

    詳細を見る 詳細を閉じる

    本研究では、がん患者の配偶者における心理的的苦痛の実態を縦断調査によりに解明し、介入研究の必要性の有無を検証した。 4つの対象者集団(①前立腺がん患者(128人)、②前立腺がん患者の妻(128人)、③非前立腺がん患者(112人)、④非前立腺がん患者の妻 (112人))を4 時期(T1:前立腺生検前、T2:告知1カ月後、T3:告知3カ月後、T4:告知6カ月後)に分けて縦断的に調査した。その結果、前立腺がん患者の妻の心理的苦痛のスコアが高い状態が告知1カ月後に認められており、この時期の介入研究が最も効果的である可能性が示された。

  11. n3系多価不飽和脂肪酸の精神的効果に関する疫学研究【継続中】 競争的資金

    2012年 ~

  12. 大学生の健康影響に関する多施設共同疫学研究【継続中】 競争的資金

    2010年 ~

  13. 高齢初産者の健康影響に関する前向きコホート研究:大崎国保コホート

    中谷 直樹

    2008年 ~ 2008年

  14. 緑茶カテキン摂取が血中アディポネクチン値に与える影響 : ランダム化比較試験

    栗山 進一, 藤田 和樹, 中谷 直樹

    2007年 ~ 2008年

    詳細を見る 詳細を閉じる

    本研究の目的は、緑茶に含まれるカテキン摂取が血中アディポネクチン値に与える影響をランダム化比較試験により検討することである。 試験参加者は20〜79歳の男女、既往歴にがん、心筋梗塞、脳血管疾患、腎疾患のない者である。平成18年6月・12月の仙台市健康増進センター減量チャレンジ講座に合わせ、講座参加者及び職員から募集を行い、51名(講座参加者31名、非参加者20名)を特定した。参加者は性(男性、女性)、減量チャレンジ講座(参加、非参加)別に無作為化され、介入群25名、対照群26名に割り付けられた。介入は介入前2週間の緑茶摂取中止を求め、その後、介入群は緑茶カテキン400mg含有飲料500mlを9週間飲用、対照群は緑茶カテキン100mg含有飲料500mlを9週間飲用した。主要効果指標として、血中アディポネクチン値を介入の前後で比較した。 ベースライン時の血中アディポネクチン値は介入群より対照群で、有意ではないが高い値を示した(介入群8.23μg/ml、対照群8.79μg/ml)。9週間の介入後、血中アディポネクチン値は両群ともに有意に上昇したが(介入群1.29μg/ml上昇、対照群1.00μg/ml上昇)、群間における変化の差は有意ではなかった[0.35μg/ml(95% CI ; -1.03, 1.74)]。副次的指標において、体重、BMI、ウエスト周囲径は、介入群・対照群の両群で介入後有意に減少したが、群間における変化の差は有意ではなかった。追加解析として、血中アディポネクチン値について性別、減量チャレンジ講座別に層別化解析を実施した。血中アディポネクチン値は男性、女性ともに、群間における変化の差は有意ではなかった[男性 : 0.52μg/ml(95% Cl ; -1.71, 2.76)、女性 : 0.34μg/ml(95% Cl ; -1.55, 2.22)]。同様に、減量チャレンジ講座参加者、非参加者ともに、群間における変化の差は有意ではなかった[参加者 : 0.15 μg/ml(95% Cl ; -1.54, 1.85)、非参加者 : 1.49μg/ml(95% Cl ; -0.46, 3.43)]。 以上のランダム化比較試験より、緑茶カテキン摂取による血中アディポネクチン値の有意な上昇は示されなかった。

  15. 自殺の危険因子に関する疫学研究 (2006年-2008年) 競争的資金

    2006年 ~ 2008年

  16. 飲酒の健康影響に関する疫学研究 (2003年-2008年) 競争的資金

    2003年 ~ 2008年

  17. がん患者の配偶者・家族の健康影響に関する疫学研究【継続中】 競争的資金

    2008年 ~

  18. 自殺リスクに影響する要因に関する大規模前向きコホート研究

    中谷 直樹

    2006年 ~ 2007年

    詳細を見る 詳細を閉じる

    [目的]本研究では、日本の一般地域住民を対象とした前向きコホート研究から、自殺リスクと関連する要因を解明し、自殺予防を目指した介入方法を確立するための計画・立案を行う。本年度は、心理社会的要因、身体的要因、生活習慣、基本特性に関するデータベースを構築し、自殺リスクと関連する要因を単変量解析によって検討した。 [方法]本研究は、大崎宮城県大崎保健所管内の1市13町に居住し、平成6年8月31日時点で40〜79歳であった国民健康保険(国保)加入者全員56,294を対象としている。平成6年10月〜12月にかけて、基本特性、心理社会的要因、身体的要因、生活習慣に関する自記式アンケート調査を行い、52,029人(92.4%)から回答を得た。解析対象者は追跡開始(1995年1月)以前の死亡者及び国保からの異動者を除いた51,218名(91.0%)とした。 [結果]2001年12月末までの追跡調査を行い、110例の自殺死亡例を確認した。多変量解析の結果、独立して自殺リスクと有意に関連したのは、男性、多量飲酒者、低頻度の果物摂取、中等度以上の痛み有り者、糖尿病既往者、長睡眠時間者であった。特に、男性を対象とした検討により、(1)多量飲酒者において、自殺リスクの有意な上昇が示された。(2)飲酒量と自殺リスクとの間に直線的な量-反応関係が示された。(3)少量飲酒者において、自殺リスクが上昇する傾向(20%リスク上昇)が示された。(4)追跡開始時点から1年以内の早期死亡例を除外した時、70%9のリスク上昇が示された。今回、精神症状と密接に関連する生活習慣要因(多量飲酒、睡眠時間)、身体的要因(痛み、糖尿病既往)が自殺リスク上昇と関連した。また、うつ病が自殺リスクを高める重要な要因であることも鑑み、今後、精神面を含めた自殺予防介入方法の確立が喫緊の課題である。

  19. がん患者のリハビリテーションに関する研究【継続中】 競争的資金

    2005年 ~

  20. 心理社会的要因とがん発症/予後に関する疫学研究【継続中】 競争的資金

    2003年 ~

  21. Epidemiological study on the association between alcohol drinking and adverse health effects (2003-2008) 競争的資金

  22. Epidemiological study on the association between psychosocial factors and the risk of suicide (2006-2008) 競争的資金

  23. Epidemiological study on the cancer rehabilitation (2005-continuing) 競争的資金

  24. Epidemiological study on the association between psychosocial factors and survival after cancer (2004-continuing) 競争的資金

  25. Epidemiological study on adverse health effects among spouse/cohabitant with breast cancer patients (2008-continuing) 競争的資金

  26. Epidemiological study on the association between psychosocial factors and the risk of cancer (2003-continuing) 競争的資金

︎全件表示 ︎最初の5件までを表示

担当経験のある科目(授業) 8

  1. 地域保健・産業保健学 埼玉県立大学

  2. 医療統計学(日本語、英語) 東北大学

  3. 健康栄養情報実習 鎌倉女子大学

  4. 生物学 鎌倉女子大学

  5. 免疫学 鎌倉女子大学

  6. 医療福祉論 鎌倉女子大学

  7. 疫学 東北大学, 鎌倉女子大学

  8. 公衆衛生学 東北大学, 宮城学院女子大学, 鎌倉女子大学、埼玉県立大学

︎全件表示 ︎最初の5件までを表示

Works(作品等) 15

  1. 中谷直樹:日本学術振興会科学研究費助成金 基盤研究(C)「大規模コホート調査における配偶者のがん既往がパートナーに及ぼす健康影響(研究課題番号:17K04190)」,研究代表者,(2017-2019)

  2. 河北新報2015年1月21日朝刊 リレーエッセー 医進伝心/ストレス軽減策を模索 http://www.kahoku.co.jp/special/spe1140/20150121_01.html

  3. 日本学術振興会科学研究費助成金 基盤研究(C) 「破局的ストレス下の慢性疾患患者における心理的・社会的側面、生活習慣及び震災影響」, 研究代表者, (2014-2016)

    中谷 直樹

    作品分類: その他

  4. 平成26年度厚生労働省委託事業 インターネットを活用した専門医の育成等事業:「心理社会学的要因とがん罹患/生存」

    中谷 直樹

    作品分類: 芸術活動

  5. 厚生労働科学研究費補助金 第3次対がん総合戦略研究事業 QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究 (研究課題番号:H22-3次がん-一般-036)」 分担研究者, (2012-2013)

  6. 文部科学省科学研究費補助金 挑戦的萌芽研究 「がん患者の配偶者における健康影響に関する縦断的研究 」, 研究代表者, (2011-2013)

  7. Homepage of the Reuters Health (August, 2010) "http://www.reuters.com/article/idUSTRE67C2O920100813"

  8. 平成22年度厚生労働省委託事業 インターネットを活用した専門医の育成等事業:「心理社会学的要因とがん罹患/生存」

  9. Homepage of the Ministry of Foreign Affairs of Denmark (April, 2008) "http://www.investindk.com/visNyhed.asp?artikelID=19507"

  10. Homepage of the Danish Cancer Society (April, 2008) "http://www.cancer.dk/Forskning/nyheder/forskningsnyheder+2008/Japanske+forskere.htm"

  11. 日本学術振興会海外特別研究員 「乳がん患者の男性パートナーにおける精神的・社会的インパクトの同定」, 研究代表者, (2008年4月-2010年3月)

  12. 文部科学省科学研究費補助金 若手研究(B) 「自殺リスクに影響する要因に関する大規模前向きコホート研究」, 研究代表者, (2006-2007)

  13. 厚生労働省科学研究費補助金 第3次対がん総合戦略総合事業 QOL向上のための各種患者支援プログラムの開発研究:「心理社会的要因とがん予後に関する大規模前向きコホート研究」, 研究協力者, (2006-現在に至る)

  14. 井上科学振興財団, 国際学会渡航費助成 (2004)

  15. 東北大学艮陵同窓会, 国際学会渡航費助成 (2003)

︎全件表示 ︎最初の5件までを表示