顔写真

アベ ヒロヤ
阿部 博弥
Hiroya Abe
所属
高等研究機構学際科学フロンティア研究所 新領域創成研究部学際基盤研究分野 デバイス・テクノロジー研究領域
職名
助教
学位
  • 博士(学術)(東北大学)

  • 修士(学術)(東北大学)

e-Rad 研究者番号
60838217
Researcher ID
プロフィール

電気化学・高分子化学を基盤に神経科学・燃料電池触媒・生物工学など幅広い分野へ展開しています。
連絡先: hiroya.abe.c4[@]tohoku.ac.jp

経歴 9

  • 2021年7月 ~ 継続中
    東北大学 プロミネントリサーチフェロー

  • 2020年4月 ~ 継続中
    東北大学 大学院工学研究科 助教

  • 2019年4月 ~ 継続中
    東北大学 学際科学フロンティア研究所 助教

  • 2020年4月 ~ 2021年3月
    文部科学省 科学技術・学術政策研究所(NISTEP) NISTEP専門調査員

  • 2019年4月 ~ 2020年3月
    東北大学 材料科学高等研究所 助教

  • 2018年10月 ~ 2019年3月
    東北大学材料科学高等研究所 助手

  • 2016年4月 ~ 2018年9月
    日本学術振興会 特別研究員 (DC1)

  • 2016年4月 ~ 2018年9月
    東北大学学際高等博士研究教育院生

  • 2015年4月 ~ 2016年3月
    東北大学 国際高等修士研究教育院生

︎全件表示 ︎最初の5件までを表示

学歴 5

  • 東北大学大学院 環境科学研究科 博士課程 修了(6ヶ月短縮)

    2016年4月 ~ 2018年9月

  • University of Louisville, KY, USA

    2017年5月 ~ 2017年8月

  • 東北大学大学院 環境科学研究科 修士課程 修了

    2014年4月 ~ 2016年3月

  • 東北大学工学部 化学・バイオ工学科 (3年次編入学)

    2012年4月 ~ 2014年3月

  • 鶴岡工業高等専門学校 物質工学科

    2007年4月 ~ 2012年3月

委員歴 4

  • [雑誌] 公益社団法人 電気化学会 季刊誌「電気化学」, 編集委員

    2023年3月 ~ 継続中

  • [学会] 一般社団法人 化学とマイクロ・ナノシステム学会 化学とマイクロ・ナノシステム学会 第48回研究会 (CHEMINAS 48) 実行委員会 実行委員

    2023年11月 ~ 2023年11月

  • [学会] 一般社団法人 化学とマイクロ・ナノシステム学会 化学とマイクロ・ナノシステム学会 第47回研究会 (CHEMINAS 47) 実行委員会 実行委員

    2023年5月 ~ 2023年5月

  • [学会] 公益社団法人 電気化学会 電気化学会第90回大会 実行委員会 大会幹事

    2023年3月 ~ 2023年3月

研究キーワード 5

  • 分析化学

  • 材料科学

  • 燃料電池

  • 電気化学

  • 高分子化学

研究分野 1

  • ナノテク・材料 / ナノマイクロシステム /

受賞 14

  1. Rising Stars in Polymer Science 2023

    2023年11月 Polymer Journal

  2. MIT Technology Review - Innovators Under 35 Japan

    2023年11月 MIT Technology Review - Innovators Under 35 Japan

  3. Falling Walls Venture Sendai 1st prize

    2021年9月 Falling Walls Venture Sendai Breaking Walls of Oxygen Activation

  4. 第26回青葉工学研究奨励賞

    2020年12月 一般財団法人 青葉工学振興会 高活性な非白金燃料電池触媒の分子設計

  5. 第46回リバネス研究費 エネルギー・エコシステム賞

    2020年1月 リバネス 生物に学ぶ燃料電池触媒分子の最適化

  6. 最優秀賞

    2019年11月 起業家甲子園・起業家万博【東北地区大会】ピッチコンテスト

  7. 第5回東北大学若手研究者アンサンブルワークショップ 優秀ポスター賞

    2019年6月 東北大学

  8. 総長賞

    2019年3月 東北大学

  9. 東北分析化学奨励賞

    2017年12月 分析化学会東北支部

  10. [科学計測振興基金] 多元物質科学奨励賞

    2017年11月 Tohoku University

  11. NNCI/NIMS Graduate Exchange Fellowship Program administered by Center for Nanotechnology Platform of NIMS

    2017年5月

  12. Pan Stanford Publisher Poster Award

    2016年10月 AsiaNANO2016, Sapporo, Japan

  13. Best oral presentation award

    2014年9月 isCEBT, Taiwan

  14. Hirakawa Prize

    2012年3月 National Institute of Technology, Tsuruoka College University

︎全件表示 ︎最初の5件までを表示

論文 43

  1. Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

    Daigo Terutsuki, Sho Miyazawa, Junya Takagi, Akihiro Yamada, Yunhao Sun, Hiroya Abe, Gaobo Wang, Matsuhiko Nishizawa

    Advanced Functional Materials 34 (2) 2023年9月7日

    出版者・発行元:Wiley

    DOI: 10.1002/adfm.202304946  

    ISSN:1616-301X

    eISSN:1616-3028

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    Abstract Spatiotemporally controlled chemical delivery is crucial for various biomedical engineering applications. Here, a novel concept of electrically controllable delivery utilizing electroosmotic flow (EOF) generated in a combination of anionic and cationic hydrogels (A‐ and C‐hydrogels) is reported. The unique advantages of the A/C‐hydrogel combination are demonstrated utilizing a flexible sheet‐shaped and a thin tubular devices. Since the directions of EOF in the A‐ and C‐hydrogels are opposite to each other, the ionic current for EOF generation flows inside the delivery devices, enabling chemical delivery without accompanying external ionic current that could stimulate target cells and tissues. A thin tubular device, which can be inserted into narrow in vivo structures and be integrated with other flexible devices, exhibits high robustness and repeatability thanks to the flexibility and water retentivity of hydrogels. The EOF devices with A/C‐hydrogels combination show high controllability superior to the pumping with a conventional syringe; the volumetric flow rate is able to be controlled proportionally to the current applied, for example, ≈0.4 µL (mA min)<sup>−1</sup> for the tubular device. The developed EOF‐based devices are versatile for delivery of most chemicals regardless of their charge and size, and have great potential for both biomedical researches and therapeutics.

  2. Iron azaphthalocyanine electrocatalysts for enhancing oxygen reduction reactions under neutral conditions and power density in microbial fuel cells

    Edwin Osebe Nyangau, Hiroya Abe, Yuta Nakayasu, Masaki Umetsu, Masaru Watanabe, Chika Tada

    Bioresource Technology Reports 23 101565-101565 2023年9月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.biteb.2023.101565  

    ISSN:2589-014X

    eISSN:2589-014X

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    Highly catalytic cathodes for oxygen reduction reactions under neutral conditions allow major improvement in the power output of microbial fuel cells (MFCs). This work reports iron azaphthalocyanine impregnated into oxidized multi-walled carbon nanotubes to form a molecularly synthesized non-precious metal electrocatalyst. The synthesized catalyst was characterized using a rotating ring and disk electrode in a neutral medium (pH = 7.4) and exhibited a four-electron transfer pathway. When incorporated as a cathode in a two-chamber MFC assembly, the electrocatalyst achieved a power density of 1.54 W/m2 and a current density of 10.7 A/m2, which was 27 % higher than a commercial platinum‑carbon catalyst. In addition, the MFC loading of the molecular catalysts reached over 80 % COD removal efficiency. This work demonstrates that the use of an electrocatalyst based on the FeN4 structure and efficient electron-withdrawing nitrogen improves the application of MFCs in low-cost wastewater treatment and the generation of electricity from wastewater.

  3. Progress on Separation and Hydrothermal Carbonization of Rice Husk Toward Environmental Applications

    Hiroya Abe, Yuta Nakayasu, Kazutoshi Haga, Masaru Watanabe

    Global Challenges 7 (8) 2023年7月19日

    出版者・発行元:Wiley

    DOI: 10.1002/gch2.202300112  

    ISSN:2056-6646

    eISSN:2056-6646

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    Abstract Owing to the increasing global demand for carbon resources, pressure on finite materials, including petroleum and inorganic resources, is expected to increase in the future. Efficient utilization of waste resources has become crucial for sustainable resource acquisition for creating the next generation of industries. Rice husks, which are abundant worldwide as agricultural waste, are a rich carbon source with a high silica content and have the potential to be an effective raw material for energy‐related and environmental purification materials such as battery, catalyst, and adsorbent. Converting these into valuable resources often requires separation and carbonization; however, these processes incur significant energy losses, which may offset the benefits of using biomass resources in the process steps. This review summarizes and discusses the high value of RHs, which are abundant as agricultural waste. Technologies for separating and converting RHs into valuable resources by hydrothermal carbonization are summarized based on the energy efficiency of the process.

  4. Mussel-inspired interfacial ultrathin films for cellular adhesion on the wrinkled surfaces of hydrophobic fluids

    Hiroya Abe, Tomoya Ina, Hirokazu Kaji, Matsuhiko Nishizawa

    Polymer Journal 55 (11) 1231-1236 2023年6月7日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41428-023-00799-0  

    ISSN:0032-3896

    eISSN:1349-0540

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    The cellular scaffold plays a crucial role in regulating cellular behavior, and controlling its mechanical properties is important in the field of regenerative medicine. In this study, common silicone oil was employed as the cellular scaffold and coated with a polymeric ultrathin film at the oil/water interface. Inspired by mussel adhesion, polydopamine ultrathin films were formed at the silicone oil/water interface even in neutral solution. The MCF-7 cells successfully adhered to the oil/water interface without aggregation during cell growth. Interfacial wrinkles were induced by changes in the oil volume and the compressive stress, and the MCF-7 cells adhered to the oil/water interface and were arranged along the wrinkles. These polydopamine interfacial films provide new opportunities for investigating the relationships between toughness and patterns for tissue engineering and regenerative medicine.

  5. The Development of Aptamer-Coupled Microelectrode Fiber Sensors (apta-μFS) for Highly Selective Neurochemical Sensing

    Tomoki Saizaki, Mahiro Kubo, Yuichi Sato, Hiroya Abe, Tomokazu Ohshiro, Hajime Mushiake, Fabien Sorin, Yuanyuan Guo

    Analytical Chemistry 95 (17) 6791-6800 2023年4月24日

    出版者・発行元:American Chemical Society (ACS)

    DOI: 10.1021/acs.analchem.2c05046  

    ISSN:0003-2700

    eISSN:1520-6882

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    The selective and sensitive sensing of neurochemicals is essential to decipher in-brain chemistry underlying brain pathophysiology. The recent development of flexible and multifunctional polymer-based fibers has been shown useful in recording and modulating neural activities, primarily electrical ones. In this study, we were able to realize fiber-based neurochemical sensing with high sensitivity and selectivity. We achieved a generalizable method to couple aptamers, a type of synthetic receptors on the carbon composites within fibers, as microsensors for highly selective neurochemical detection. Such an aptamer-coupled microelectrode fiber sensor (apta-μFS) enables simple, label-free, and sensitive dopamine (DA) detection down to 5 nM with ultrahigh specificity across major interferents. We succeeded in monitoring DA selectively within the living brain using our apta-μFS. We further showed the proof-of-concept of using microelectronic fiber-based toolsets to target neural pathways across electrical and chemical modalities. In summary, such fiber-based toolsets hold great potential to advance multimodal mechanistic understanding of brain pathophysiology.

  6. Frustoconical porous microneedle for electroosmotic transdermal drug delivery

    Daigo Terutsuki, Reiji Segawa, Shinya Kusama, Hiroya Abe, Matsuhiko Nishizawa

    Journal of Controlled Release 354 694-700 2023年2月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.jconrel.2023.01.055  

    ISSN:0168-3659

    eISSN:1873-4995

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    A truncated cone-shaped porous microneedle (PMN) made of poly-glycidyl methacrylate was studied as a minimally invasive tool for transdermal drug delivery. The transdermal electrical resistance of a pig skin was evaluated during the indentation of the PMNs, revealing that the frustoconical PMN (300 μm height) significantly reduced the resistance of the skin by expanding the stratum corneum without penetrating into the skin. A thin film of poly (2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) was grafted onto the inner wall of the microchannels of the frustoconical PMN to generate electroosmotic flow (EOF) upon current application in the direction of injection of the drug into the skin. Owing to the synergy of the expansion of the stratum corneum and the EOF-promotion, the PAMPS-modified frustoconical PMN effectively enhances the penetration of larger (over 500 Da) molecules, such as dextran (∼10 kDa).

  7. Comprehensive Cell Adhesion Analysis Using Electrochemiluminescence Imaging and Electrochemical Impedance Spectroscopy 査読有り

    Kimiharu OBA, Kosuke INO, Yoshinobu UTAGAWA, Hiroya ABE, Hitoshi SHIKU

    Electrochemistry 2023年

    出版者・発行元:The Electrochemical Society of Japan

    DOI: 10.5796/electrochemistry.23-68109  

    ISSN:1344-3542

    eISSN:2186-2451

  8. Porous Microneedle-Based Potentiometric Sensor for Intradermal Electrolyte Monitoring

    Daigo TERUTSUKI, Shuhei YAMAGUCHI, Yuina ABE, Hiroya ABE, Matsuhiko NISHIZAWA

    Electrochemistry 91 (4) 047007-047007 2023年

    出版者・発行元:The Electrochemical Society of Japan

    DOI: 10.5796/electrochemistry.23-00027  

    ISSN:1344-3542

    eISSN:2186-2451

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    A porous microneedle (PMN)-based potentiometric ion sensor for transdermal monitoring of electrolytes in the interstitial fluid was developed. The carbon coating with an ion-selective membrane was formed on half of the needle tip as the working electrode, while the Ag/AgCl reference electrode was mounted on the PMN chip. This design of a single needle-type configuration allows lower invasive transdermal sensing than the conventional system with multiple needle electrodes. The fabricated potentiometric sensor showed the near-Nernstian responses to Na+ concentration in the excised pig skin, demonstrating the applicability for monitoring intradermal electrolytes.

  9. Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation

    Daigo Terutsuki, Hayato Yoroizuka, Shin ichiro Osawa, Yuka Ogihara, Hiroya Abe, Atsuhiro Nakagawa, Masaki Iwasaki, Matsuhiko Nishizawa

    Advanced Healthcare Materials 11 (23) 2201627-2201627 2022年12月7日

    出版者・発行元:Wiley

    DOI: 10.1002/adhm.202201627  

    ISSN:2192-2640

    eISSN:2192-2659

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    An intrinsically soft organic electrode consisting of poly(3,4-ethylenedioxythiophene)-modified polyurethane (PEDOT-PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self-closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2 mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (≈200 Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT-PU (≈27 mF cm−2) ensures a safe stimulation of living tissues without Faradaic reactions. The practical performance of the cuff electrode for VN stimulation is demonstrated by observation of bradycardia induction in a pig.

  10. Water-proof anti-drying enzymatic O2 cathode for bioelectric skin patch

    Daigo Terutsuki, Kohei Okuyama, Haoyu Zhang, Hiroya Abe, Matsuhiko Nishizawa

    Journal of Power Sources 546 231945-231945 2022年10月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.jpowsour.2022.231945  

    ISSN:0378-7753

    eISSN:1556-5068

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    A water-proof anti-drying enzymatic O2 cathode for a deformable bioelectric skin patch was developed by laminating a thin membrane (50 μm thick) of polydimethylsiloxane (PDMS) to a bilirubin oxidase (BOD)-modified carbon fabric (CF) electrode. The PDMS membrane and the CF electrode were adhered so that a microspace serving as the oxygen reservoir was formed at their interface, enabling the operation of the patch even in a soaked condition for more than a few minutes. Even if the oxygen in the reservoir was depleted by soaking for too long, the patch performance could be recovered within a few tens of seconds by taking it out of the water, owing to the excellent oxygen-permeability of the thin PDMS membrane. The anti-drying effect of PDMS prolonged the lifetime of the bioelectric patch wrapped around a finger for more than 3 h while maintaining transdermal current of ∼20 μA cm−2.

  11. Intradermal measurement of reactive oxygen species using open-tip porous microneedles

    Yuina Abe, Shuhei Yamaguchi, Hiroya Abe, Ryohei Takizawa, Yuki Tatsui, Matsuhiko Nishizawa

    Microelectronic Engineering 265 111877-111877 2022年9月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.mee.2022.111877  

    ISSN:0167-9317

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    Reactive oxygen species (ROS), which constitute a representative group of substances associated with skin health, are promising indicators of oxidative stress. A local electrochemical system can measure ROS with minimal invasiveness. In this study, a microneedle-based amperometric sensor is developed for real-time monitoring of changes in the H2O2 concentration of the skin. Two electrodes can be mounted on a single open-tip porous microneedle (PMN), which allows local measurement without intradermal noise caused by the high resistance and non-uniform distribution of the potential difference. The PMN electrode shows a current response in accordance with the H2O2 concentration, and amperometric measurement of ex vivo skin samples is successfully performed. The results indicate that a compact system based on a single needle is a promising tool for intracutaneous sensing of biological signals.

  12. Intradermal vaccination via electroosmotic injection from a porous microneedle patch

    Hitoshi Terui, Natsumi Kimura, Reiji Segawa, Shinya Kusama, Hiroya Abe, Daigo Terutsuki, Kenshi Yamasaki, Matsuhiko Nishizawa

    Journal of Drug Delivery Science and Technology 75 103711-103711 2022年9月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.jddst.2022.103711  

    ISSN:1773-2247

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    The feasibility of the electroosmotic flow (EOF)-promoted intradermal vaccination via a porous microneedle (PMN) has been demonstrated by in-vitro and in-vivo experiments with mice. The EOF-promoted directional transport of ovalbumin (OVA) through a negatively charged PMN was quantitatively evaluated by experiments using a side-by-side Franz cell. The preloading of the OVA solution into a PMN chip and its effective injection into mouse skin pieces were examined by microscope observations. By using mice, the immunological effect of the PMN-based intradermal vaccination has been proved by ELISA analysis of serum OVA-specific immunoglobulins (IgG1 and IgE). Although the passive diffusion-based release of OVA from PMN was too slow for effective vaccination, the EOF-assisted injection was found to be fast enough to effectively induce production of immunoglobulins.

  13. Thermally Drawn CNT-Based Hybrid Nanocomposite Fiber for Electrochemical Sensing

    Rino Nishimoto, Yuichi Sato, Jingxuan Wu, Tomoki Saizaki, Mahiro Kubo, Mengyun Wang, Hiroya Abe, Inès Richard, Tatsuo Yoshinobu, Fabien Sorin, Yuanyuan Guo

    Biosensors 12 (8) 559-559 2022年8月

    出版者・発行元:MDPI AG

    DOI: 10.3390/bios12080559  

    eISSN:2079-6374

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    Nowadays, bioelectronic devices are evolving from rigid to flexible materials and substrates, among which thermally-drawn-fiber-based bioelectronics represent promising technologies thanks to their inherent flexibility and seamless integration of multi-functionalities. However, electrochemical sensing within fibers remains a poorly explored area, as it imposes new demands for material properties—both the electrochemical sensitivity and the thermomechanical compatibility with the fiber drawing process. Here, we designed and fabricated microelectrode fibers made of carbon nanotube (CNT)-based hybrid nanocomposites and further evaluated their detailed electrochemical sensing performances. Carbon-black-impregnated polyethylene (CB-CPE) was chosen as the base material, into which CNT was loaded homogeneously in a concentration range of 3.8 to 10 wt%. First, electrical impedance characterization of CNT nanocomposites showed a remarkable decrease of the resistance with the increase in CNT loading ratio, suggesting that CNTs notably increased the effective electrical current pathways inside the composites. In addition, the proof-of-principle performance of fiber-based microelectrodes was characterized for the detection of ferrocenemethanol (FcMeOH) and dopamine (DA), exhibiting an ultra-high sensitivity. Additionally, we further examined the long-term stability of such composite-based electrode in exposure to the aqueous environment, mimicking the in vivo or in vitro settings. Later, we functionalized the surface of the microelectrode fiber with ion-sensitive membranes (ISM) for the selective sensing of Na+ ions. The miniature fiber-based electrochemical sensor developed here holds great potential for standalone point-of-care sensing applications. In the future, taking full advantage of the thermal drawing process, the electrical, optical, chemical, and electrochemical modalities can be all integrated together within a thin strand of fiber. This single fiber can be useful for fundamental multi-mechanistic studies for biological applications and the weaved fibers can be further applied for daily health monitoring as functional textiles.

  14. Tough Mechanically Interlocked Transparent Interface of Hydrogels and Elastomers for Biomedical Applications

    Daigo Terutsuki, Ryota Suwabe, Hiroya Abe, Matsuhiko Nishizawa

    Macromolecular Materials and Engineering 307 (7) 2100931-2100931 2022年7月

    出版者・発行元:Wiley

    DOI: 10.1002/mame.202100931  

    ISSN:1438-7492

    eISSN:1439-2054

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    Hydrogel-based soft, wet devices receive a great deal of attention in advanced medical engineering, which will require integration of hydrogels and elastomers through a transparent and tightly bound interface. Here, the strength of the mechanical interlock of the hydrogel–elastomer interface is studied using microstructured poly(dimethylsiloxane) (PDMS) sheets embedded in a polyvinyl alcohol (PVA) hydrogel. The PDMS sheet, which exhibits micro-protrusions (cuboid and frustum-shape), has a tensile strength of 10 kPa, which can be sufficient for gentle handling of the PVA/PDMS assembly. The PDMS protrusions (even the frustum-shape) are found to drag out from the deformed PVA hydrogel without any destruction. The tensile strength of the embedded PDMS is further increased by attaching a thin roof film to bridge the protrusions. These microbridge structures are more than ten times stronger than those with only protrusions, and extraction of the PDMS microbridges caused the destruction of PVA hydrogel. It is also confirmed by a 90°-peeling test that the microbridge structure is effective for tough lamination of the PVA on PDMS. The PVA/PDMS assembly with the microbridged interface exhibits transparency and deformability that will be sufficient for biomedical applications.

  15. Series module of quinone-based organic supercapacitor (>6 V) with practical cell structure

    Yuto Katsuyama, Takayuki Takehi, Shu Sokabe, Mai Tanaka, Mizuki Ishizawa, Hiroya Abe, Masaru Watanabe, Itaru Honma, Yuta Nakayasu

    Scientific Reports 12 (1) 2022年3月10日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41598-022-07853-6  

    eISSN:2045-2322

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    Abstract Inexpensive, high-performing, and environmentally friendly energy storage devices are required for smart grids that efficiently utilize renewable energy. Energy storage devices consisting of organic active materials are promising because organic materials, especially quinones, are ubiquitous and usually do not require harsh conditions for synthesis, releasing less CO<sub>2</sub> during mass production. Although fundamental research-scale aqueous quinone-based organic supercapacitors have shown excellent energy storage performance, no practical research has been conducted. In this study, we aimed to develop a practical-scale aqueous-quinone-based organic supercapacitor. By connecting 12 cells of size 10 cm × 10 cm × 0.5 cm each in series, we fabricated a high-voltage (&gt; 6 V) aqueous organic supercapacitor that can charge a smartphone at a 1 C rate. This is the first step in commercializing aqueous organic supercapacitors that could solve environmental problems, such as high CO<sub>2</sub> emissions, air pollution by toxic metals, and limited electricity generation by renewable resources.

  16. Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines 査読有り

    Hiroya Abe, Kaito Sato, Natsumi Kimura, Shinya Kusama, Daisuke Inoue, Kenshi Yamasaki, Matsuhiko Nishizawa

    Advanced NanoBiomed Research 2 (1) 2100066-2100066 2022年1月

    出版者・発行元:Wiley

    DOI: 10.1002/anbr.202100066  

    ISSN:2699-9307

    eISSN:2699-9307

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    A charged porous microneedle (PMN) generates the electroosmotic flow (EOF) and promotes the through-needle transport of molecules and particles, indicating its applicability for the EOF-based low-invasive transdermal delivery of drugs and vaccines. The negatively charged PMN is prepared by grafting a thin film of poly (2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) onto the inner wall of the microchannels of the polyglycidyl methacrylate PMN. Promoted transport from anode to cathode is observed for albumin, Au nanoparticles (15, 50 nm), and silica beads (100 nm), indicating the generation of an EOF strong enough to transport these negatively charged larger size species against their electrophoretic motion. A model antigen ovalbumin (OVA) is preloaded in the PMN, and is injected to a hydrogel and a pig skin with a higher efficiency (more than 2 times) than the conventional diffusion-based passive release. These results successfully demonstrate the novel EOF-based effective injection of drugs and vaccines into the skin, achieved by the newly developed charged PMN.

  17. Synthesis of unused-wood-derived C-Fe-N catalysts for oxygen reduction reaction by heteroatom doping during hydrothermal carbonization and subsequent carbonization in nitrogen atmosphere

    Yasuto Goto, Yuta Nakayasu, Hiroya Abe, Yuto Katsuyama, Takashi Itoh, Masaru Watanabe

    Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 379 (2209) 20200348-20200348 2021年11月1日

    出版者・発行元:The Royal Society

    DOI: 10.1098/rsta.2020.0348  

    ISSN:1364-503X

    eISSN:1471-2962

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    There is an urgent need to develop renewable sources of energy and use existing resources in an efficient manner. In this study, in order to improve the utilization of unused biomass and develop green processes and sustainable technologies for energy production and storage, unused Douglas fir sawdust (SD) was transformed into catalysts for the oxygen reduction reaction. Fe and N were doped into SD during hydrothermal carbonization, and the N- and Fe-doped wood-derived carbon (Fe/N/SD) was carbonized in a nitrogen atmosphere. After the catalyst had been calcined at 800°C, its showed the highest current density (−5.86 mAcm <sup>−2</sup> at 0.5 V versus reversible hydrogen electrode or RHE) and E <sub>onset</sub> value (0.913 V versus RHE). Furthermore, its current density was higher than that of Pt/C (20 wt% Pt) (−5.66 mA cm <sup>−2</sup> @0.5 V versus RHE). Finally, after 50 000 s, the current density of sample Fe/N/SD (2 : 10 : 10) remained at 79.3% of the initial value. Thus, the synthesized catalysts, which can be produced readily at a low cost, are suitable for use in various types of energy generation and storage devices, such as fuel cells and air batteries. This article is part of the theme issue ‘Bio-derived and bioinspired sustainable advanced materials for emerging technologies (part 2)’.

  18. Biodegradable Porous Microneedles for an Electric Skin Patch 査読有り

    Hiroya Abe, Yuuya Matsui, Natsumi Kimura, Matsuhiko Nishizawa

    Macromolecular Materials and Engineering 306 (9) 2100171-2100171 2021年9月

    出版者・発行元:Wiley

    DOI: 10.1002/mame.202100171  

    ISSN:1438-7492

    eISSN:1439-2054

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    An array of porous microneedles (PMNs) made of biodegradable poly(lactic-co-glycolic acid) (PLGA) is fabricated by a combination of molding and freeze-drying methods. The optimized mixture of PLGA and 1,4-dioxane is poured into a mold of a microneedle array, followed by the freezing and sublimation of the frozen particles of 1,4-dioxane, a procedure that left an interconnecting porous structure in the PLGA with a porosity around 50%. The mechanical strength of the PMN made of PLGA (PLGA-PMN) is reinforced by modification with carboxymethylcellulose (CMC), resulting in sufficient strength enough for insertion into an excised porcine skin. The transdermal resistance is significantly decreased by the CMC-modified PLGA-PMN, which would improve the efficiency and safety of DC current-based transdermal techniques, including the electrical monitoring of the skin condition and iontophoresis for drug delivery and medical diagnosis.

  19. Light in Electrochemistry

    Hiroya Abe, Tomoki Iwama, Yuanyuan Guo

    Electrochem 2 (3) 472-489 2021年8月26日

    出版者・発行元:MDPI AG

    DOI: 10.3390/electrochem2030031  

    eISSN:2673-3293

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    Electrochemistry represents an important analytical technique used to acquire and assess chemical information in detail, which can aid fundamental investigations in various fields, such as biological studies. For example, electrochemistry can be used as simple and cost-effective means for bio-marker tracing in applications, such as health monitoring and food security screening. In combination with light, powerful spatially-resolved applications in both the investigation and manipulation of biochemical reactions begin to unfold. In this article, we focus primarily on light-addressable electrochemistry based on semiconductor materials and light-readable electrochemistry enabled by electrochemiluminescence (ECL). In addition, the emergence of multiplexed and imaging applications will also be introduced.

  20. Aqueous dispersion and tuning surface charges of polytetrafluoroethylene particles by bioinspired polydopamine-polyethyleneimine coating via one-step method 国際誌 査読有り

    Manjit Singh Grewal, Hiroya Abe, Yasutaka Matsuo, Hiroshi Yabu

    Royal Society Open Science 8 (8) 210582-210582 2021年8月

    出版者・発行元:The Royal Society

    DOI: 10.1098/rsos.210582  

    eISSN:2054-5703

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    We propose a surface modification of poorly dispersive polytetrafluoroethylene (PTFE) particles via bioinspired polydopamine–polyethyleneimine (PDA–PEI) which conferred PTFE particles a uniform dispersion in aqueous medium. With increasing dopamine concentration in the reaction solution, dispersity of PTFE particles improved and the surface charges of particles changed from negative to positive due to an increase of surface coverage of PDA–PEI layers. Simplicity of the method here outlines an attractive route for surface modification of inert surfaces useful for large-scale applications.

  21. Enzyme electrode for glucose oxidation using low‐solubility 4‐aminodiphenylamine derivatives as electron mediator

    Yosuke Masakari, Naoya Totsuka, Yasutomo Shinohara, Shotaro Yoshida, Hiroya Abe, Kotaro Ito, Matsuhiko Nishizawa

    Electrochemical Science Advances 2 (4) e2100036 2021年6月26日

    出版者・発行元:Wiley

    DOI: 10.1002/elsa.202100036  

    ISSN:2698-5977

    eISSN:2698-5977

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    A novel enzyme electrode system for glucose oxidation was constructed by co-immobilization of glucose dehydrogenase (GDH) and N,N’-diphenyl-p-phenylenediamine (DPPD) on carbon electrodes. This enzyme electrode system was applied to porous carbon fabric to produce a glucose oxidation current of 7 mA/cm2, while the electrode catalytic activity was maintained at approximately 100% for more than 4 h, indicating that DPPD molecules were stably retained on the electrodes during the continuous redox cycling. Further, a stable mediation was also observed for other 4-aminodiphenylamine derivatives similar to DPPD. The difference was found in the adsorptivity between the reduced and oxidized forms of DPPD on the carbon electrode, suggesting that a portion of oxidized DPPD can access the active center of GDH without desorbing to solution. This electrode system with 4-aminodiphenylamine derivatives can be used in sensors for glucose monitoring and to anodes of separator-free glucose fuel cells.

  22. Bio-inspired Incrustation Interfacial Polymerization of Dopamine and Cross-linking with Gelatin toward Robust, Biodegradable Three-Dimensional Hydrogels 査読有り

    Hiroya Abe, Hiroshi Yabu

    Langmuir 37 (20) 6201-6207 2021年5月25日

    出版者・発行元:American Chemical Society (ACS)

    DOI: 10.1021/acs.langmuir.1c00364  

    ISSN:0743-7463

    eISSN:1520-5827

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    In nature, laccase enzymatically catalyzes the reaction of phenolic compounds with oxygen to produce hardened surfaces known as cuticles on insects and plants. Inspired by this natural process, the present work investigated a robust, biodegradable hydrogel synthesized from dopamine and gelatin. This gel is obtained by the oxidation of dopamine dissolved in water, after which the resulting quinone compound automatically undergoes self-polymerization. The oxidized dopamine subsequently undergoes Schiff base and Michael addition reactions with gelatin, such that the exposed gelatin surface cross-links to generate a continuous hardened hydrogel film. Because gelatin transitions between sol and gel states with changes in temperature, two- and three-dimensional structures could be obtained from the gel state. This bio-inspired interfacial cross-linking reaction provides a simple means of forming complex morphologies and represents a promising technique for bio-applications.

  23. Biomimetic antibiofouling oil infused honeycomb films fabricated using breath figures

    Ryunosuke Shimura, Hiroya Abe, Hiroshi Yabu, Mei-Fang Chien, Chihiro Inoue

    POLYMER JOURNAL 53 (6) 713-717 2021年2月

    出版者・発行元:SPRINGERNATURE

    DOI: 10.1038/s41428-021-00467-1  

    ISSN:0032-3896

    eISSN:1349-0540

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    Microorganisms form strong communities known as biofilms, which are ubiquitous in both natural and artificial environments and lead to problems such as health hazards and energy loss. The most effective solution against biofouling is to prevent the initial adhesion of the microbial cells to the material surface. This paper reports the fabrication of slippery liquid-infused porous surfaces (SLIPSs) through a simple method and the antibiofouling properties of these surfaces against microorganisms. The principle of these surfaces is inspired by Nepenthes, which are pitcher plants. SLIPSs can be easily and inexpensively generated through the breath figure method and ultrasonic processing. The developed silicon oil-infused substrate exhibited a low fall angle and antifouling characteristics. The results suggest that the proposed simple method can be used to successfully generate an antibiofouling substrate.

  24. Transdermal electroosmotic flow generated by a porous microneedle array patch

    Shinya Kusama, Kaito Sato, Yuuya Matsui, Natsumi Kimura, Hiroya Abe, Shotaro Yoshida, Matsuhiko Nishizawa

    Nature Communications 12 (1) 658 2021年1月28日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41467-021-20948-4  

    ISSN:2041-1723

    eISSN:2041-1723

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    Abstract A microneedle array is an attractive option for a minimally invasive means to break through the skin barrier for efficient transdermal drug delivery. Here, we report the applications of solid polymer-based ion-conductive porous microneedles (PMN) containing interconnected micropores for improving iontophoresis, which is a technique of enhancing transdermal molecular transport by a direct current through the skin. The PMN modified with a charged hydrogel brings three innovative advantages in iontophoresis at once: (1) lowering the transdermal resistance by low-invasive puncture of the highly resistive stratum corneum, (2) transporting of larger molecules through the interconnected micropores, and (3) generating electroosmotic flow (EOF). In particular, the PMN-generated EOF greatly enhances the transdermal molecular penetration or extraction, similarly to the flow induced by external pressure. The enhanced efficiencies of the EOF-assisted delivery of a model drug (dextran) and of the extraction of glucose are demonstrated using a pig skin sample. Furthermore, the powering of the PMN-based transdermal EOF system by a built-in enzymatic biobattery (fructose / O<sub>2</sub> battery) is also demonstrated as a possible totally organic iontophoresis patch.

  25. Bioimaging using bipolar electrochemical microscopy with improved spatial resolution 査読有り

    Tomoki Iwama, Kumi Y. Inoue, Hiroya Abe, Tomokazu Matsue, Hitoshi Shiku

    Analyst 145 (21) 6895-6900 2020年11月7日

    出版者・発行元:Royal Society of Chemistry (RSC)

    DOI: 10.1039/d0an00912a  

    ISSN:0003-2654

    eISSN:1364-5528

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    © The Royal Society of Chemistry. In this study, we developed bipolar electrochemical microscopy (BEM) using a closed bipolar electrode (cBPE) array with an electrochemiluminescence (ECL) detecting system. Because cBPEs are not directly connected to a detector, high spatio-temporal resolution imaging can be achieved by fabricating a microelectrode array in which each electrode point is arranged in a short interval. A cBPE array with individual cBPEs arranged in 41 μm intervals was successfully fabricated by depositing gold in the pores of a track-etched membrane using electroless plating. Using BEM with the cBPE array, which has a higher density of electrode points than the conventional multi-electrode array, we effectively demonstrated the imaging of [Fe(CN)6]3- diffusion and the respiratory activity of MCF-7 spheroids with high spatio-temporal resolution. This journal is

  26. Totally organic electrical skin patch powered by flexible biobattery

    Shotaro Yoshida, Hiroya Abe, Yuina Abe, Shinya Kusama, Kenichi Tsukada, Ryo Komatsubara, Matsuhiko Nishizawa

    JOURNAL OF PHYSICS-ENERGY 2 (4) 044004 2020年10月

    出版者・発行元:IOP PUBLISHING LTD

    DOI: 10.1088/2515-7655/abb873  

    ISSN:2515-7655

    eISSN:2515-7655

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    An electrical skin patch that can be flexibly attached to the skin and activated in 30 s by adding water was developed by integrating a built-in flexible glucose/O(2)biobattery. The latter consisted of a glucose dehydrogenase (GDH)-modified anode and an iron(II) phthalocyanine (FePc)-modified cathode. The quick activation of the patch components by water addition deep inside the patch was achieved by using a flexible water-absorbing sponge containing glucose and buffer electrolyte. A patch current of about 10 mu A was maintained for more than 12 h by optimizing the amount of glucose and electrolyte contained in the sponge tank. The entire patch was soft and highly flexible to conform to curved skin surfaces, owing to its thinness (<2 mm) and the flexibility of all the patch components, including the enzyme electrodes based on the carbon fabric.

  27. Totally transparent hydrogel-based subdural electrode with patterned salt bridge

    Ayaka Nishimura, Ryota Suwabe, Yuka Ogihara, Shotaro Yoshida, Hiroya Abe, Shin-ichiro Osawa, Atsuhiro Nakagawa, Teiji Tominaga, Matsuhiko Nishizawa

    Biomedical Microdevices 22 (3) 57 2020年8月22日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1007/s10544-020-00517-0  

    ISSN:1387-2176

    eISSN:1572-8781

  28. S/N Co-Doped Hollow Carbon Particles for Oxygen Reduction Electrocatalysts Prepared by Spontaneous Polymerization at Oil-Water Interfaces 査読有り

    Hiroya Abe, Kohei Nozaki, Shu Sokabe, Akichika Kumatani, Tomokazu Matsue, Hiroshi Yabu

    ACS Omega 5 (29) 18391-18396 2020年7月28日

    出版者・発行元:American Chemical Society (ACS)

    DOI: 10.1021/acsomega.0c02182  

    ISSN:2470-1343

    eISSN:2470-1343

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    Copyright © 2020 American Chemical Society. We herein report that sulfur and nitrogen co-doped hollow spherical carbon particles can be applied to oxygen reduction reaction (ORR) electrocatalysts prepared by calcination of polydopamine (PDA) hollow particles. The hollow structure of PDA was formed by auto-oxidative interfacial polymerization of dopamine at the oil and water interface of emulsion microdroplets. The PDA was used as the nitrogen source as well as a platform for sulfur-doping. The obtained sulfur and nitrogen co-doped hollow particles showed a higher catalytic activity than that of nonsulfur-doped particles and nonhollow particles. The high ORR activity of the calcined S-doped PDA hollow particles could be attributed to the combination of nitrogen and sulfur active sites and the large surface areas owing to a hollow spherical structure.

  29. Redox cycling-based electrochemical CMOS imaging sensor for real time and selective imaging of redox analytes

    Hiroya Abe, Hiroshi Yabu, Ryota Kunikata, Atsushi Suda, Masahki Matsudaira, Tomokazu Matsue

    Sensors and Actuators B: Chemical 304 127245-127245 2020年2月

    出版者・発行元:Elsevier BV

    DOI: 10.1016/j.snb.2019.127245  

    ISSN:0925-4005

  30. Fe azaphthalocyanine unimolecular layers (Fe AzULs) on carbon nanotubes for realizing highly active oxygen reduction reaction (ORR) catalytic electrodes

    Hiroya Abe, Yutaro Hirai, Susumu Ikeda, Yasutaka Matsuo, Haruyuki Matsuyama, Jun Nakamura, Tomokazu Matsue, Hiroshi Yabu

    NPG Asia Materials 11 (1) 2019年10月18日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41427-019-0154-6  

    ISSN:1884-4049

    eISSN:1884-4057

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    Abstract A new class of Pt-free catalysts was designed that included molecular iron phthalocyanine (FePc) derivatives, namely, iron azaphthalocyanine (FeAzPc) unimolecular layers (Fe AzULs) adsorbed on oxidized multiwall carbon nanotubes (oxMWCNTs). FeAzPcs were dissolved in organic solvents such as dimethyl sulfoxide (DMSO), and catalytic electrodes modified with molecularly adsorbed FeAzPcs were successfully prepared. The optimized composition of the catalytic electrodes was determined, and the electrodes exhibited superior activity for the oxygen reduction reaction (ORR) and better durability than conventional FePc catalytic electrodes and commercial Pt/C due to the electron-withdrawing properties of the pyridinic nitrogen in FeAzPcs. The catalytic electrodes that were molecularly modified with FeAzPcs have higher activities than those composed of FeAzPc crystals and oxMWCNTs. To the best of our knowledge, among all of the conventional catalysts based on modified MWCNTs and oxMWCNTs, this catalyst exhibits the highest activity. Unlike other Pt-free catalytic electrodes, the Fe AzUL catalytic electrodes can be prepared by low-cost processing without pyrolysis and are therefore promising catalytic electrode materials for applications, such as polymer electrolyte fuel cells and metal–air batteries.

  31. Preparation of Hierarchic Porous Films of α-MnO2 Nanoparticles by Using the Breath Figure Technique and Application for Hybrid Capacitor Electrodes 査読有り

    Nobuhiro Shimamura, Ryuji Kanda, Yuma Matsukubo, Yutaro Hirai, Hiroya Abe, Yuji Hirai, Tsukasa Yoshida, Hiroshi Yabu, Akito Masuhara

    ACS Omega 4 (2) 3827-3831 2019年2月21日

    DOI: 10.1021/acsomega.8b03381  

    ISSN:2470-1343

    eISSN:2470-1343

  32. N- and Fe-containing Carbon Films Prepared by Calcination of Polydopamine Composites Self-assembled at Air/Water Interface for Oxygen Reduction Reaction 査読有り

    Hiroya Abe, Kohei Nozaki, Akichika Kumatani, Tomokazu Matsue, Hiroshi Yabu

    Chemistry Letters 48 (2) 102-105 2019年

    出版者・発行元:The Chemical Society of Japan

    DOI: 10.1246/cl.180872  

    ISSN:0366-7022

    eISSN:1348-0715

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    © 2019 The Chemical Society of Japan Here we report the synthesis and electrocatalytic properties of polymer films containing nitrogen and iron. The films were prepared by calcination of polydopamine, polyethyleneimine and iron. The composite films were self-assembled at the air/ water interface, and exhibited higher activity for the oxygen reduction reaction than glassy carbon or calcined polydopamine films. These results suggest that such calcined composite films have potential applications as cathodes in polymer electrolyte fuel cells.

  33. Shape Transformation Photolithography: Self-Assembled Arrays of Suspended MEMS Structures from Patterned Polymer Membranes 査読有り

    Andriy Sherehiy, Jeremy M. Rathfon, Hiroya Abe, Sri Sukanta Chowdhury, Robert W. Cohn

    ACS Omega 3 (12) 18489-18498 2018年12月27日

    出版者・発行元:American Chemical Society ({ACS})

    DOI: 10.1021/acsomega.8b02763  

    ISSN:2470-1343

    eISSN:2470-1343

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    © 2018 American Chemical Society. Suspended micromechanical structures are typically formed by dissolving underlying spacer material. However, capillary force-induced collapse during solvent removal can damage soft structures. If instead capillary forces are directed in the plane, they can drive liquid polymeric bridges to directly transform into suspended fibers. The various capillary force-directed methods for fabricating arrays of suspended fibers have suffered from either low manufacturing rates or an inability to produce arbitrary patterns. Shape transformation photolithography (STP) demonstrated herein is a method of producing arbitrarily patterned arrays of suspended fibers that are potentially capable of high fabrication rates. In STP, holes are prepatterned in a polymer nanofilm supported on a micropillar array, and then the film is heated above its glass transition temperature. First, the holes expand by dewetting and then capillary forces drive thinning of the polymer channels defined by the holes. Prepatterning overcomes the energy barrier for hole nucleation and ensures that all fibers form at the same time and with similar diameters. Arrays of fibers and fiber lattice networks are formed from dyed polystyrene films that are patterned with nanosecond laser pulses at 532 nm. The exposure threshold for forming holes is 10.5 mJ/cm2 for single pulses and 3.3 mJ/cm2 per pulse for repetitive pulsing, which is only about 3× larger than the dose available from current 193 nm wafer-stepping projection printers that are used in device manufacture. With the increased absorption of polystyrene at 193 nm and with additional proposed material modifications to the thin film, it may even be possible to employ STP in production wafer steppers at economically feasible manufacturing rates of over 50 wafers/h.

  34. Simultaneous and Selective Imaging of Dopamine and Glutamate Using an Enzyme‐modified Large‐scale Integration (LSI)‐based Amperometric Electrochemical Device 査読有り

    Hiroya Abe, Tomoki Iwama, Hiroshi Yabu, Kosuke Ino, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Tomokazu Matsue

    Electroanalysis 30 (12) 2841-2846 2018年12月

    出版者・発行元:Wiley

    DOI: 10.1002/elan.201800386  

    ISSN:1040-0397

    eISSN:1521-4109

  35. Chemical imaging using a closed bipolar electrode array 査読有り

    Tomoki Iwama, Kumi Y. Inoue, Hiroya Abe, Tomokazu Matsue

    Chemistry Letters 47 (7) 843-845 2018年

    出版者・発行元:The Chemical Society of Japan

    DOI: 10.1246/cl.180303  

    ISSN:0366-7022

    eISSN:1348-0715

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    © 2018 The Chemical Society of Japan. In this study, we developed a new chemical imaging platform that uses a closed bipolar electrode (cBPE) array for electrochemiluminescence (ECL) detection. The cBPE array was successfully applied to use in the chemical imaging of molecular distributions by injection and a self-induced redox cycling. The results show the possibility of high-resolution chemical imaging using a cBPE array.

  36. Electrochemicolor Imaging Using an LSI-Based Device for Multiplexed Cell Assays 査読有り

    Yusuke Kanno, Kosuke Ino, Hiroya Abe, Chika Sakamoto, Takehiro Onodera, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue

    Analytical Chemistry 89 (23) 12778-12786 2017年12月5日

    出版者・発行元:American Chemical Society ({ACS})

    DOI: 10.1021/acs.analchem.7b03042  

    ISSN:0003-2700

    eISSN:1520-6882

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    © 2017 American Chemical Society. Multiplexed bioimaging systems have triggered the development of effective assays, contributing new biological information. Although electrochemical imaging is beneficial for quantitative analysis in real time, monitoring multiple cell functions is difficult. We have developed a novel electrochemical imaging system, herein, using a large-scale integration (LSI)-based amperometric device for detecting multiple biomolecules simultaneously. This system is designated as an electrochemicolor imaging system in which the current signals from two different types of biomolecules are depicted as a multicolor electrochemical image. The mode-selectable function of the 400-electrode device enables the imaging system and two different potentials can be independently applied to the selected electrodes. The imaging system is successfully applied for detecting multiple cell functions of the embryonic stem (ES) cell and the rat pheochromocytoma (PC12) cell aggregates. To the best of our knowledge, this is the first time that a real-time electrochemical mapping technique for multiple electroactive species, simultaneously, has been reported. The imaging system is a promising bioanalytical method for exploring complex biological phenomena.

  37. Reversible Shape Transformation of Ultrathin Polydopamine-Stabilized Droplet 査読有り

    Hiroya Abe, Tomokazu Matsue, Hiroshi Yabu

    Langmuir 33 (25) 6404-6409 2017年6月27日

    出版者・発行元:American Chemical Society ({ACS})

    DOI: 10.1021/acs.langmuir.7b01355  

    ISSN:0743-7463

    eISSN:1520-5827

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    © 2017 American Chemical Society. Here we report on the flattening of water droplets using an ultrathin membrane of autopolymerized polydopamine at the air/water interface. This has only been previously reported with the use of synthetic or extracted peptides, two-dimensional designed synthetic peptide thin films with thicknesses of several tens of nanometers. However, in the previous study, the shape of the water droplet was changed irreversibly and the phenomenon was observed only at the air/water interface. In the present study, an ultrathin polydopamine membrane-stabilized droplet induced the flattening of a water droplet at the air/liquid and liquid/liquid interfaces because a polydopamine membrane was spontaneously formed at these interfaces. Furthermore, a reversible transformation of the droplet to flat and dome shape droplets were discovered at the liquid/liquid interface. These are a completely new system because the polydopamine membrane is dynamically synthesized at the interface and the formation speed of the polydopamine membrane overcomes the flattening time scale. These results will provide new insight into physical control of the interfacial shapes of droplets.

  38. Biomimetic bubble-repellent tubes: Microdimple arrays enhance repellency of bubbles inside of tubes 査読有り

    Jun Kamei, Hiroya Abe, Hiroshi Yabu

    Langmuir 33 (2) 585-590 2017年

    出版者・発行元:American Chemical Society ({ACS})

    DOI: 10.1021/acs.langmuir.6b04155  

    ISSN:0743-7463

    eISSN:1520-5827

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    © 2016 American Chemical Society. The adhesion of bubbles underwater remains the greatest cause of malfunctions in applications such as microfluidics, medical devices, and heat exchangers. Recently, the combination of oxidization and peeling the top layer of self-organized honeycomb films with an adhesive tape resulted in the formation of an ultra-bubble-repellent and pillared polymer surface structure. However, the fabrication of honeycomb films on the inner surface of tubes and the formation of structured hydrophilic textures by peeling the top layer of honeycomb films still remain problematic. In this report, a simple fabrication technique for producing a honeycomb-patterned polymer film on the interior of a tube by dip-coating a polymer solution and blowing humid air in the tube is described. Furthermore, an ultra-bubblerepellent dimple-arrayed structure was fabricated by applying ultrasonication to the honeycomb structure formed on the interior surface of the tubes.

  39. Thermally Stable Honeycomb-Patterned Porous Films of a Poly(L-lactic acid) and Poly(D-lactic acid) Stereo Complex Prepared Using the Breath Figure Technique 査読有り

    Hiroya Abe, Yutaro Hirai, Hiroshi Yabu

    Macromolecular Materials and Engineering 301 (5) 523-529 2016年5月1日

    出版者・発行元:Wiley

    DOI: 10.1002/mame.201500474  

    ISSN:1438-7492

    eISSN:1439-2054

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    © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Porous polymer materials prepared from biodegradable polymers have received considerable attention due to their potential as cell culture scaffolds for tissue engineering. Porous materials are generally sterilized by autoclaving prior to use as cell culture scaffolds to avoid unexpected biological infection. However, the melting point of biodegradable polymers is typically lower than the temperature used in autoclave sterilization. Here, the preparation of honeycomb films comprising a poly(L-lactic acid) (PLLA) and poly(D-lactic acid) (PDLA) stereo complex is described and their thermal stabilities are evaluated. The hierarchic photochemical patterning of PLLA/PDLA stereo complex honeycomb-patterned films by UV-O3 treatment is also demonstrated. Porous films of stereo-complexed poly(lactic acid)s sufficiently stabile to withstand autoclave sterilization are successfully prepared by using the breath figure technique. Surface patterning of porous stereo-complexed poly(lactic acid)s are also achieved by UV-O3 treatment.

  40. Electrochemical imaging for single-cell analysis of cell adhesion using a collagen-coated large-scale integration (LSI)-based amperometric device 査読有り

    Hiroya Abe, Yusuke Kanno, Kosuke Ino, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue

    Electrochemistry 84 (5) 364-367 2016年5月

    出版者・発行元:The Electrochemical Society of Japan

    DOI: 10.5796/electrochemistry.84.364  

    ISSN:1344-3542

    eISSN:2186-2451

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    © 2016 The Electrochemical Society of Japan, All rights reserved. We here report the electrochemical imaging of cell adhesion using a large-scale integration (LSI)-based amperometric device, called a Bio-LSI device. The device consists of 400 sensor electrodes arranged with a pitch of 250μm. The device surface was modified with collagen to assist in the culture of MCF-7 cells and promote their adhesion. The cells disturb the electrochemical reaction of redox mediators, allowing the electrochemical signal to be used to evaluate cell adhesion at the single-cell level. This approach was applied to a cell detachment test. The results show that the Bio-LSI device is a promising tool for single-cell analysis.

  41. Potentiometric bioimaging with a large-scale integration (LSI)-based electrochemical device for detection of enzyme activity 査読有り

    Yusuke Kanno, Kosuke Ino, Chika Sakamoto, Kumi Y. Inoue, Masahki Matsudaira, Atsushi Suda, Ryota Kunikata, Tomohiro Ishikawa, Hiroya Abe, Hitoshi Shiku, Tomokazu Matsue

    Biosensors and Bioelectronics 77 709-714 2016年3月15日

    出版者・発行元:Elsevier {BV}

    DOI: 10.1016/j.bios.2015.10.021  

    ISSN:0956-5663

    eISSN:1873-4235

    詳細を見る 詳細を閉じる

    © 2015 Elsevier B.V. This paper describes potentiometric bioimaging for enzyme activity using a large-scale integration (LSI)-based electrochemical device with 400 sensors. Potentiometric detection is useful for bioimaging because redox species are not consumed or produced during the detection process; therefore, there is no effect on cell activity and the detectable signal is sustained. In this study, the potentiometer mode of the LSI-based device was applied for the detection of glucose oxidase (GOx) and alkaline phosphatase (ALP) activity. The enzyme activities were quantitatively detected within the concentration ranges of 25-250. μg/mL and 0.10-5.0. ng/mL. In addition, GOx activity in hydrogels and the ALP activity of embryoid bodies (EBs) from embryonic stem (ES) cells were successfully imaged based on detection of the open circuit potentials of individual sensors in real time. To the best of our knowledge, this is the first report of potentiometric imaging using LSI-based electrochemical arrays to detect enzyme activity in ES cells. The LSI-based device is thus demonstrated to be a promising tool for bioimaging of enzyme activity.

  42. Electrochemical Imaging of Dopamine Release from Three-Dimensional-Cultured PC12 Cells Using Large-Scale Integration-Based Amperometric Sensors 査読有り

    Hiroya Abe, Kosuke Ino, Chen Zhong Li, Yusuke Kanno, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue

    Analytical Chemistry 87 (12) 6364-6370 2015年6月16日

    出版者・発行元:American Chemical Society ({ACS})

    DOI: 10.1021/acs.analchem.5b01307  

    ISSN:0003-2700

    eISSN:1520-6882

    詳細を見る 詳細を閉じる

    © 2015 American Chemical Society. In the present study, we used a large-scale integration (LSI)-based amperometric sensor array system, designated Bio-LSI, to image dopamine release from three-dimensional (3D)-cultured PC12 cells (PC12 spheroids). The Bio-LSI device consists of 400 sensor electrodes with a pitch of 250 μm for rapid electrochemical imaging of large areas. PC12 spheroids were stimulated with K<sup>+</sup> to release dopamine. Poststimulation dopamine release from the PC12 spheroids was electrochemically imaged using the Bio-LSI device. Bio-LSI clearly showed the effects of the dopaminergic drugs l-3,4-dihydroxyphenylalanine (l-DOPA) and reserpine on K<sup>+</sup>-stimulated dopamine release from PC12 spheroids. Our results demonstrate that dopamine release from PC12 spheroids can be monitored using the device, suggesting that the Bio-LSI is a promising tool for use in evaluating 3D-cultured dopaminergic cells and the effects of dopaminergic drugs. To the best of our knowledge, this report is the first to describe electrochemical imaging of dopamine release by PC12 spheroids using LSI-based amperometric sensors.

  43. Feedback mode-based electrochemical imaging of conductivity and topography for large substrate surfaces using an LSI-based amperometric chip device with 400 sensors 査読有り

    Yusuke Kanno, Kosuke Ino, Kumi Y. Inoue, Mustafa Şen, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hiroya Abe, Chen Zhong Li, Hitoshi Shiku, Tomokazu Matsue

    Journal of Electroanalytical Chemistry 741 109-113 2015年3月15日

    出版者・発行元:Elsevier {BV}

    DOI: 10.1016/j.jelechem.2015.01.020  

    ISSN:1572-6657

    eISSN:1873-2569

    詳細を見る 詳細を閉じる

    © 2015 Elsevier B.V. All rights reserved. Feedback mode-based electrochemical imaging of conductivity and topography for large substrate surfaces is presented using a large-scale integration (LSI)-based amperometric chip device with 400 sensors at a pitch of 250 μm. The LSI-based chip device has enabled rapid electrochemical imaging of large substrate surfaces, compared to scanning electrochemical microscope (SECM). Substrates modified with conductive and insulating materials were placed onto the device to acquire electrochemical signals from the substrate surface using positive and negative feedback signals. The conductivity and topography of the substrate were successfully imaged, indicating that the feedback mode-based electrochemical imaging with such a device is useful to characterize large-area substrate surfaces.

︎全件表示 ︎最初の5件までを表示

MISC 45

  1. 体に速く強く接着するハイドロゲル

    阿部博弥

    化学同人「化学」 2023年3月

  2. Development of shape-comfortable hydrogel-based cuff electrode for vagus nerve stimulation 査読有り

    H. Yoroizuka, D. Terutsuki, S. Osawa, Y. Ogihara, H. Abe, A. Nakagawa, M. Iwasaki, M. Nishizawa

    The 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2022) _ (_) _-_ 2022年10月

  3. Hydrogel-based transparent subdural electrode with ionic connection 査読有り

    Ayaka Nishimura, Ryota Suwabe, Yuka Ogihara, Yuina Abe, Hiroya Abe, Shotaro Yoshida, Matsuhiko Nishizawa

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences _ (_) 518-519 2020年10月

  4. Wearable patch-type device for bio-information monitoring with porous microneedle and flexible Ag/AgCl reference electrode 査読有り

    Ryohei Takizawa, Yuina Abe, Bibek Rau, Hajime Konno, Natsumi Kimura, Shotaro Yoshida, Hiroya Abe, Matsuhiko Nishizawa

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences _ (_) 504-505 2020年10月

  5. Development of a high spatio-temporal resolution electrochemical imaging system using a closed bipolar electrode array 査読有り

    Tomoki Iwama, Kumi Inoue, Hiroya Abe, Tomokazu Matsue, Hitoshi Shiku

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 _ (_) 1380-1381 2019年10月

  6. キャパシタ電極を指向したハイブリッドα-MnO<sub>2</sub>ナノ粒子によるハニカム構造膜の作製

    神田龍兒, 横山雅晃, 平井裕士, 吉田司, 阿部博弥, 阿部博弥, 藪浩, 増原陽人, 増原陽人

    応用物理学会秋季学術講演会講演予稿集(CD-ROM) 80th 2019年

    ISSN:2436-7613

  7. 鉄フタロシアニン誘導体の高活性酸素還元特性評価

    阿部博弥, 阿部博弥, 平井裕太郎, 伊藤晃寿, 末永智一, 藪浩

    応用物理学会秋季学術講演会講演予稿集(CD-ROM) 80th 2019年

    ISSN:2436-7613

  8. 鉄フタロシアニンの誘導体化による酸素還元反応の高活性化メカニズム

    松山治薫, 阿部博弥, 阿部博弥, 伊藤晃寿, 藪浩, 中村淳

    応用物理学会秋季学術講演会講演予稿集(CD-ROM) 80th 2019年

    ISSN:2436-7613

  9. ポリドーパミンコンポジット膜の作製と焼成による触媒電極への応用

    野崎浩平, 阿部博弥, 平井裕太郎, 藪浩

    東北大学金属材料研究所新素材共同研究開発センター共同利用研究報告書(CD-ROM) 2018 2019年

  10. 酸素還元触媒の分子設計

    阿部博弥, 阿部博弥, 平井裕太郎, 伊藤晃寿, 末永智一, 藪浩

    電池討論会PDF要旨集(CD-ROM) 60th 2019年

  11. 表面修飾かつ3次元造形可能な界面架橋ゲル

    阿部博弥, 阿部博弥, 藪浩

    化学とマイクロ・ナノシステム学会研究会講演要旨集 40th 2019年

  12. 鉄フタロシアニン誘導体触媒電極による高活性酸素還元反応

    阿部博弥, 平井裕太郎, 野崎浩平, 末永智一, 藪浩

    応用物理学会春季学術講演会講演予稿集(CD-ROM) 65th 2018年

  13. ポリドーパミン-鉄コンポジット膜の作製と焼成による触媒電極への応用

    野崎浩平, 阿部博弥, 熊谷明哉, 末永智一, 藪浩

    応用物理学会春季学術講演会講演予稿集(CD-ROM) 65th 2018年

  14. スーパーキャパシタ電極を指向したMnO<sub>2</sub>ナノ粒子によるポリピロール被覆ハニカム構造膜の作製

    島村宣寛, 松久保侑馬, 平井祐太郎, 阿部博弥, 藪浩, 増原陽人, 増原陽人

    応用物理学会春季学術講演会講演予稿集(CD-ROM) 65th 2018年

  15. 神経伝達物質の選択的イメージングに向けた電気化学デバイスの開発

    阿部博弥, 岩間智紀, 藪浩, 井上(安田)久美, 國方亮太, 須田篤史, 松平昌昭, 末永智一

    日本分析化学会年会講演要旨集 67th 2018年

  16. ポリドーパミンコンポジット膜の作製と焼成による触媒電極への応用

    野崎浩平, 阿部博弥, 熊谷明哉, 末永智一, 藪浩

    電気化学秋季大会講演要旨集(CD-ROM) 2018 2018年

  17. 鉄フタロシアニン系触媒による高活性な酸素還元反応の実現

    阿部博弥, 平井裕太郎, 野崎浩平, 末永智一, 藪浩

    電気化学秋季大会講演要旨集(CD-ROM) 2018 2018年

  18. MnO<sub>2</sub>ナノ粒子によるハニカム構造を有するポリピロール被覆キャパシタ電極の開発

    島村宣寛, 神田龍兒, 平井裕太郎, 阿部博弥, 藪浩, 増原陽人, 増原陽人

    高分子学会予稿集(CD-ROM) 67 (2) 2018年

  19. 鉄フタロシアニン系触媒による高活性な燃料電池触媒電極の達成

    阿部博弥, 平井裕太郎, 末永智一, 藪浩

    ポリマー材料フォーラム講演予稿集 27th 2018年

  20. ポリドーパミン-鉄コンポジット膜の作製と焼成による触媒電極への応用

    野崎浩平, 阿部博弥, 末永智一, 熊谷明哉, 藪浩

    ポリマー材料フォーラム講演予稿集 27th 2018年

  21. ポリドーパミンコンポジット膜の作製と焼成による触媒電極への応用

    野崎浩平, 阿部博弥, 末永智一, 熊谷明哉, 藪浩

    電池討論会講演要旨集 59th 2018年

  22. 鉄フタロシアニン類縁体を用いた高活性な燃料電池触媒電極の達成

    阿部博弥, 平井裕太郎, 末永智一, 藪浩

    電池討論会講演要旨集 59th 2018年

  23. 気液界面に自己組織化的に形成したゼラチン-ポリドーパミン複合膜

    阿部博弥, 末永智一, 藪浩

    高分子学会予稿集(CD-ROM) 67 (1) 2018年

  24. スーパーキャパシタの電極を指向した両親媒性ポリマー被覆α-MnO<sub>2</sub>ナノ粒子の合成およびハニカム構造膜の作製

    松久保侑馬, 島村宣寛, 平井裕太郎, 阿部博弥, 藪浩, 増原陽人, 増原陽人

    応用物理学会春季学術講演会講演予稿集(CD-ROM) 64th 2017年

  25. 気液界面に形成したポリドーパミン薄膜と液滴平面化

    阿部博弥, 末永智一, 末永智一, 藪浩

    応用物理学会春季学術講演会講演予稿集(CD-ROM) 64th 2017年

  26. 動く発光団FLAPを有するポリウレタンフィルムの合成とメカノクロミック特性

    阿部博弥, 小谷亮太, 横山創一, 末永智一, 末永智一, 大須賀篤弘, 齊藤尚平, 齊藤尚平, 藪浩

    高分子学会予稿集(CD-ROM) 66 (1) 2017年

  27. 超音波ビーズミル法を用いたオールウェットプロセスによるα-MnO<sub>2</sub>キャパシタ電極の開発

    島村宣寛, 松久保侑馬, 平井裕太郎, 阿部博弥, 藪浩, 増原陽人, 増原陽人

    化学系学協会東北大会プログラムおよび講演予稿集 2017 2017年

  28. α型MnO<sub>2</sub>ナノ粒子で構成されたハニカム構造を有するスーパーキャパシタ電極の作製

    松久保侑馬, 平井裕太郎, 阿部博弥, 藪浩, 増原陽人, 増原陽人

    化学系学協会東北大会プログラムおよび講演予稿集 2017 2017年

  29. フレキシブル透明電極に向けた気泡を鋳型とする無電解メッキマイクロパターニング

    阿部博弥, 末永智一, 藪浩

    化学とマイクロ・ナノシステム学会研究会講演要旨集 36th 2017年

  30. 神経伝達物質の選択的同時イメージングに向けた電極アレイの作製

    阿部博弥, 岩間智紀, 藪浩, 伊野浩介, 井上(安田)久美, 國方亮太, 須田篤史, 松平昌昭, 末永智一

    電気化学会東北支部セミコンファレンス講演論文集 48th 2017年

  31. 燃料電池空気極の触媒を志向したポリドーパミン焼成薄膜の作製

    野崎浩平, 阿部博弥, 熊谷明哉, 藪浩, 末永智一

    電気化学会東北支部セミコンファレンス講演論文集 48th 2017年

  32. DNAチップの開発に向けた電気化学クリック反応による表面修飾 査読有り

    坂本ちか, 阿部博弥, 伊野浩介, 藤野智子, 磯部寛之, 珠玖仁, 末永智一

    化学とマイクロ・ナノシステム学会誌 16 (1) 41-42 2017年

  33. ガラス円管内への自己組織化多孔質高分子膜の作製

    阿部博弥, 伊野浩介, 藪浩, 末永智一, 末永智一

    化学とマイクロ・ナノシステム学会研究会講演要旨集 33rd 2016年

  34. 動く発光団FLAPの化学修飾とメカノ応答発光フィルムの開発

    小谷亮太, 横山創一, 阿部博弥, 藪浩, 齊藤尚平, 大須賀篤弘

    基礎有機化学討論会要旨集 27th 2016年

  35. ポリドーパミン自己組織化膜による液滴平面化現象

    阿部博弥, 伊野浩介, 藪浩, 末永智一, 末永智一

    高分子学会予稿集(CD-ROM) 65 (1) 2016年

  36. ポリ乳酸ステレオコンプレックスを用いて作製したハニカムフィルムの耐熱性

    平井裕太郎, 阿部博弥, 藪浩

    高分子学会予稿集(CD-ROM) 65 (1) 2016年

  37. Multicolor electrochemical imaging for simultaneous multiplex cell assay using a chip device 査読有り

    Y. Kanno, K. Ino, H. Abe, K. Y. Inoue, M. Matsudaira, A. Suda, R. Kunikata, H. Shiku, T. Matsue

    20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 104-105 2016年

    詳細を見る 詳細を閉じる

    In this study, we constructed a new electrochemical imaging system using a chip device for detecting multiple cell activities simultaneously. This system can acquire multicolor electrochemical images composed of electrochemical signals from two different electrodes which were applied with different potentials. We successfully applied the system to measuring respiration activity and dopamine release from a PC12 cell aggregate at the same time. The new imaging system will be a widely applicable analytical method for cell analysis.

  38. CMOS型電気化学デバイスを用いた神経細胞塊から放出される神経伝達物質のイメージング

    阿部博弥, 伊野浩介, LI Chen‐Zhong, 菅野祐介, 井上久美, 國方亮太, 須田篤史, 松平昌昭, 高橋康史, 珠玖仁, 末永智一

    電気化学会大会講演要旨集(CD-ROM) 82nd ROMBUNNO.PS31 2015年3月9日

  39. Lsi-based amperometric device for electrochemical imaging of drug effect on dopamine release from three-dimensional cultured pc12 cells 査読有り

    H. Abe, K. Ino, C. Z. Li, Y. Kanno, K. Y. Inoue, A. Suda, R. Kunikata, M. Matsudaira, Y. Takahashi, H. Shiku, T. Matsue

    MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 1598-1600 2015年

    詳細を見る 詳細を閉じる

    © 15CBMS-0001. We report a large-scale integration (LSI) based amperometric chip device containing 400 sensors with a pitch of 250 μm and its applications for biological analysis of dopamine release from three-dimensional (3D) cultured cells using rat pheochromocytoma (PC12) cells as a neural cell model. The 3D cultured PC12 cells (PC12 spheroids) were stimulated with a high K+ solution to induce dopamine release. We showed clearly drug effects of dopaminergic drugs L-3,4-dihydroxyphenylalanine, (L-DOPA) and reserpine on dopamine release from PC12 spheroids. Our results indicate that the device is a useful tool for evaluating the effects of dopaminergic drugs.

  40. Potentiometric imaging of stem cells using an lsi-based electrochemical chip device with 400 microelectrodes 査読有り

    Y. Kanno, K. Ino, C. Sakamoto, K. Y. Inoue, M. Matsudaira, A. Suda, R. Kunikata, H. Abe, H. Shiku, T. Matsue

    MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 1686-1688 2015年

    詳細を見る 詳細を閉じる

    © 15CBMS-0001. In this study, we demonstrated a potentiometric imaging of enzyme activity in mouse embryonic stem (ES) cells using an LSI-based electrochemical chip device with 400 microelectrodes. Successful results on the detection of the alkaline phosphatase activity of ES cells show that the potentiometric imaging using our LSI-based device will be a widely applicable method for cell analysis.

  41. 神経細胞から分泌されるシグナル物質の解析に向けた電気化学デバイスの開発

    阿部博弥, 菅野祐介, 伊野浩介, 高橋康史, 井上(安田)久美, 珠玖仁, LI Chenzhong, 末永智一

    化学系学協会東北大会プログラムおよび講演予稿集 2014 90 2014年9月20日

  42. バイオミメティック撥気泡表面の管内表面への作製

    亀井潤, 阿部博弥, 齊藤祐太, 下村政嗣, 下村政嗣, 藪浩

    応用物理学会春季学術講演会講演予稿集(CD-ROM) 61st 2014年

  43. ポリ乳酸ステレオコンプレックスを用いた高耐熱性ハニカムフィルムの作製

    阿部博弥, 齊藤祐太, 樋口剛志, 藪浩, 藪浩

    高分子学会予稿集(CD-ROM) 63 (1) 2014年

  44. 水中における撥気泡表面の管内表面への作製

    亀井潤, 齊藤祐太, 阿部博弥, 藪浩

    高分子学会予稿集(CD-ROM) 63 (1) 2014年

  45. 水中におけるバイオミメティック撥気泡表面の管内表面への作製

    亀井潤, 阿部博弥, 齊藤祐太, 藪浩

    応用物理学会秋季学術講演会講演予稿集(CD-ROM) 75th 2014年

    ISSN:2436-7613

︎全件表示 ︎最初の5件までを表示

講演・口頭発表等 40

  1. 電気化学発光法を用いた細胞が放出するROS検出法の検討

    増子美侑、平本薫、阿部博弥、伊野浩介、珠玖仁

    生体界面研究会(細胞環境のシグナリングと計測) 2023年12月18日

  2. 細胞機能のin situ計測に向けた多孔膜電気化学デバイス

    宇田川喜信、伊野浩介、阿部博弥、珠玖仁

    生体界面研究会(細胞環境のシグナリングと計測) 2023年12月18日

  3. 生物が持つ優れた構造からヒントを得て、安価で高性能な燃料電池触媒を開発 招待有り

    阿部博弥

    MIT Technology Review 日本版, Innovators Under 35 2023年11月30日

  4. 多孔膜電極を用いたin situ電気化学計測による細胞分析

    宇田川喜信、伊野浩介、阿部博弥、珠玖仁

    動物実験代替法学会 第36回大会 2023年11月27日

  5. 電気化学発光と電気化学インピーダンス分光法を用いた細胞接着の評価

    大場公晴、伊野浩介、宇田川喜信、阿部博弥、珠玖仁

    第54回セミコンファレンス、第36回若手会 2023年11月12日

  6. 微小プローブ電極を用いた生体関連分子凝集体の電気化学的計測

    林元嘉、阿部博弥、伊野浩介、珠玖仁

    第54回セミコンファレンス、第36回若手会 2023年11月12日

  7. 細胞機能のin situ計測に向けた多孔膜電極ウェルデバイスの開発

    宇田川喜信、伊野浩介、阿部博弥、珠玖仁

    化学とマイクロ・ナノシステム学会 第48回研究会(CHEMICAS48) 2023年11月6日

  8. 電気化学測定を用いたヒト腸管モデルのイメージングと表面粗さの評価

    伊藤千聖、伊野浩介、阿部博弥、珠玖仁

    化学とマイクロ・ナノシステム学会 第48回研究会(CHEMICAS48) 2023年11月6日

  9. 木製微生物燃料電池による環境発電

    阿部博弥, Nyangau Edwin Osebe, 中安祐太, 渡邉賢, 梅津将喜, 多田千佳

    化学とマイクロ・ナノシステム学会 第48回研究会 (CHEMINAS 48), 熊本 2023年11月

  10. 生体分子凝集体の計測・制御に向けた微小プローブ電極の開発

    林元嘉、阿部博弥

    2023年 学変A超越分子システム領域会議、若手会 2023年9月21日

  11. 電気化学センシングによるハイドロゲルファイバー内の培養細胞の呼吸活性解析

    伊野浩介、宇田川喜信、和知麻奈、阿部博弥、珠玖仁

    日本分析化学会 第72年会 2023年9月13日

  12. 走査型イオンコンダクタンス顕微鏡を用いた非侵襲トポグラフィーイメージングによる、培養条件がヒト間葉系幹細胞の軟骨分化に与える影響の測定

    望月紳司、阿部博弥、伊野浩介、珠玖仁

    2023年 電気化学秋季大会 2023年9月11日

  13. 走査型イオンコンダクタンス顕微鏡を用いた ヒト間葉系幹細胞及びヒト胚性幹細胞の細胞形態による分化評価

    野澤洸太, 梨本裕司, 阿部博弥, 伊野浩介, 珠玖仁

    2023年 電気化学秋季大会 2023年9月11日

  14. 3D プリンタによる電極付き二層型マイクロ流体デバイスの新たな作製法

    今野杏,伊野浩介,阿部博弥,珠玖仁

    2023年 電気化学秋季大会 2023年9月11日

  15. Electrochemiluminescence imaging and electrochemical impedance spectroscopy of cell adhesion

    大場公晴、伊野浩介、宇田川喜信、阿部博弥、珠玖仁

    令和5年度化学系学協会東北大会および日本化学会東北支部80周年記念国際会議 2023年9月8日

  16. Electrochemiluminescence biosensing for detecting metabolic activities of 3D spheroids

    Ryota Shikuwa, Kosuke Ino, Kaoru Hiramoto, Hiroya Abe, Hitoshi Shiku

    令和5年度化学系学協会東北大会および日本化学会東北支部80周年記念国際会議 2023年9月8日

  17. Drug permeability and topography analyses of human intestinal models on porous membranes using electrochemical measurements 国際会議

    Chisato Ito, Kosuke Ino, Hiroya Abe, Hitoshi Shiku

    RSC Tokyo International Conference 2023 2023年9月7日

  18. Interfacial Polyelectrolyte Complexation Hydrogel Fibers for Cell Culture Applications 国際会議

    Yoshinobu Utagawa, Kosuke Ino, Hitoshi Shiku

    International society of Electrochemistry 2023年9月3日

  19. Topographic evaluation of embryonic and mesenchymal stem cells using scanning ion conductance microscopy 国際会議

    Kota Nozawa, Yuji Nashimoto, Hiroya Abe, Kosuke Ino, Hitoshi Shiku

    Tohoku University GP-Chem Chemistry Summer School 2023 2023年8月7日

  20. Evaluation of mesenchymal stem cells during differentiation using electrochemical and microfluidic techniques 国際会議

    An Konno, Kosuke Ino, Kaoru Hiramoto, Yuji Nashimoto, Hiroya Abe, Hitoshi Shiku

    Tohoku University GP-Chem Chemistry Summer School 2023 2023年8月7日

  21. VNS治療に向けた自動的に巻き付くハイドロゲル製カフ型電極の開発

    今村文哉, 安斎優希, 照月大悟, 大沢伸一郎, 鎧塚隼人, 阿部博弥, Wang Gaobo, 中川敦寛, 岩崎真樹, 西澤松彦

    日本機械学会 第35回バイオエンジニアリング講演会, 宮城 2023年6月

  22. バイオデバイスの生体内接着を目的とした生体模倣水中接着ハイドロゲルの開発

    吉原大智, 阿部博弥, 照月大悟, 西澤松彦

    化学とマイクロ・ナノシステム学会 第47回研究会 (CHEMINAS 47), 宮城 2023年5月

  23. 生体内利用に向けた高柔軟性バイオ発電デバイスの開発

    野間口友哉, 奥山浩平, 照月大悟, 阿部博弥, 西澤松彦

    化学とマイクロ・ナノシステム学会 第47回研究会 (CHEMINAS 47), 宮城 2023年5月

  24. 迷走神経に自動的に巻き付くハイドロゲル製カフ電極の開発と巻き付き速度の評価

    今村文哉, 安斎優希, 照月大悟, 大沢伸一郎, 鎧塚隼人, 阿部博弥, 中川敦寛, 岩崎真樹, 西澤松彦

    化学とマイクロ・ナノシステム学会 第47回研究会 (CHEMINAS 47), 宮城 2023年5月

  25. 乾燥PVAゲルを基材として迷走神経刺激に応用可能な柔らかく自動的に巻きつく電極の開発

    安斎優希, 今村文哉, 照月大悟, 大沢伸一郎, 鎧塚隼人, 阿部博弥, 岩崎真樹, 中川敦寛, 冨永悌二, 西澤松彦

    化学とマイクロ・ナノシステム学会 第47回研究会 (CHEMINAS 47), 宮城 2023年5月

  26. 電気浸透流を利用した経皮通電両極マイクロニードルの開発

    加藤康佑, 井上大輔, 宮澤匠生, 高木淳也, 山田輝拓, 照月大悟, 阿部博弥, 西澤松彦

    電気化学会第90回大会, 宮城 2023年3月

  27. バイオ通電パッチのための防水BODカソード開発

    奥山浩平, 照月大悟, 阿部博弥, 西澤松彦

    電気化学会第90回大会, 宮城 2023年3月 2023年3月

  28. 電気駆動式ハイドロゲルポンプの開発

    宮澤匠生, 加藤康佑, 山田輝拓, 髙木淳也, 井上大輔, 阿部博弥, 照月大悟, 西澤松彦

    電気化学会第90回大会, 宮城 2023年3月

  29. バイオデバイスの生体接着に向けた生体模倣温度応答性ハイドロゲルの開発

    吉原大智, 阿部博弥, 照月大悟, 西澤松彦

    電気化学会第90回大会, 宮城 2023年3月

  30. 電気浸透流を利用する薬剤浸透促進に向けた円錐台形ポーラスマイクロニードルの開発

    瀬川嶺士, 青木出琉, 照月大悟, 阿部博弥, 西澤松彦

    電気化学会第90回大会, 宮城 2023年3月

  31. 光治療及び表皮電位モニタリングを両立するメッシュ型電極の開発

    辰井裕希, 照月大悟, 阿部博弥, 西澤松彦

    電気化学会第90回大会, 宮城 2023年3月

  32. 五配位構造を有する生物模倣鉄アザフタロシアニン触媒 招待有り

    阿部博弥, 西澤松彦

    第32回日本MRS年次大会 2022年12月6日

  33. Three-in-One Woody Zinc-Air Battery Engraved by Laser

    Hiroya Abe

    2022 MRS Fall Meeting & Exhibit 2022年11月30日

  34. 荷電ハイドロゲルを用いた埋込み型電気浸透流ポンプシステムの開発

    宮澤匠生, 山田輝拓, 高木淳也, 阿部博弥, 照月大悟, 西澤松彦

    第32回日本MRS年次大会, 神奈川 2022年12月

  35. 電気浸透流を利用した経皮投薬のための円錐台形マイクロニードルの開発

    瀬川嶺士, 青木出琉, 照月大悟, 阿部博弥, 西澤松彦

    第32回日本MRS年次大会, 神奈川 2022年12月

  36. 界面重合を利用したポリドーパミン膜上での細胞培養

    阿部博弥

    第71回高分子討論会 2022年9月7日

  37. 電気浸透流を利用した経皮通電パッチの開発

    井上大輔, 宮澤匠, 高木淳也, 山田輝拓, 加藤康佑, 照月大悟, 阿部博弥, 西澤松彦

    2022年電気化学秋季大会, 神奈川 2022年9月

  38. ポーラスマイクロニードル電極による皮膚内物質センシング

    山口修平, 瀧沢凌平, 辰井裕希, 阿部結奈, 阿部博弥, 照月大悟, 西澤松彦

    2022年電気化学秋季大会, 神奈川 2022年9月

  39. 油の上で細胞を培養するには?

    阿部博弥

    化学とマイクロ・ナノシステム学会第45回研究会 2022年5月22日

  40. Laser-induced carbon from wood chips for electrocatalyst of oxygen reduction reaction

    Hiroya Abe

    2022 Spring Meeting of the European Materials Research Society (E-MRS) 2022年5月

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産業財産権 1

  1. 電池要素、金属空気電池、微生物燃料電池、及びその製造方法

    阿部博弥

    産業財産権の種類: 特許権

共同研究・競争的資金等の研究課題 6

  1. 脳機能評価に資する光電気化学顕微鏡の確立

    阿部 博弥

    2022年4月1日 ~ 2025年3月31日

  2. 生体接着する生物模倣バイオセンサー

    阿部博弥

    2022年10月 ~ 2025年3月

  3. 有機性廃棄物資源循環に資する木質由来炭素を活用したエネルギー変換システム

    中安祐太, 阿部博弥

    2022年4月 ~ 2025年3月

  4. 電子伝達可能な無細胞分子システムの合成およびエネルギー移動制御

    阿部 博弥

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A)

    研究種目:Grant-in-Aid for Transformative Research Areas (A)

    研究機関:Tohoku University

    2022年6月 ~ 2024年3月

  5. 脳の領域間コミュニケーションを可視化する超高感度・多項目同時計測電気化学デバイス

    阿部 博弥

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    研究種目:Grant-in-Aid for Early-Career Scientists

    研究機関:Tohoku University

    2019年4月1日 ~ 2022年3月31日

    詳細を見る 詳細を閉じる

    脳内の数百μmスケールでの多様な神経伝達物質の可視化・関連付けを行うことで、海馬や前頭葉などの領域間における様々な情報伝達、つまり「脳内領域間コミュニケーション」を可視化することができる。これにより、多様な神経伝達物質と脳機能の関連性が明らかになり、脳科学・神経科学の発展に大きく貢献できる。本研究では、領域間コミュニケーションにおける神経伝達物質の可視化を可能とする超高感度・多項目・広範囲・リアルタイムイメージング可能な新規電気化学デバイスを開発する。本デバイスでは、「集積回路型電気化学イメージングデバイス」と、神経伝達物質の超高感度検出が可能な「レドックスサイクル誘導電極アレイ」および「酵素修飾電極」を組み合わせることで、超高感度・多項目解析を実現し、脳内の各領域間コミュニケーション、特に刺激に対する様々な神経伝達物質の関連性の解明を目指す。1年目はレドックスサイクル誘導電極アレイの作製および組織工学を利用した脳模倣組織の作製を検討した。 2年目となる本年度は、レドックスサイクル誘導可能な電極アレイの最適化や、予備試験的にin vivoでの神経伝達物質放出挙動および活動電位の計測を行った。また、脳模倣組織作成のための3次元細胞足場の作製を試みた。in vivo試験では、刺激に対する神経伝達物質放出挙動や活動電位の変化をリアルタイムで計測することに成功している。また、温度の制御により除去可能な鋳型を用いて、筒の形状など複雑な3次元ハイドロゲルの造形に成功している。この3次元ハイドロゲルはタンパク質表面修飾可能であり、より複雑な3次元細胞組織の作製制御に貢献が期待される。

  6. 脳機能解明に向けたシグナル伝達の多項目同時イメージング法の開発

    阿部 博弥

    2016年4月22日 ~ 2019年3月31日

    詳細を見る 詳細を閉じる

    脳に関する情報伝達や記憶といった機能や神経変性疾患の理解は、光学的手法や機能的核磁気 共鳴画像法などの分析技術の発達により確実に深まっている。一方で、これらの分析手法は定 量性が乏しいことや、単項目解析であることが課題であった。そこで、定量性を有し、多項目同時解析可能な新規電気化学イメージングセンサを開発する。具体的には、これまでに開発した集積回路を利用した電気化学デバイスを基板として、集積回路への多項目計測システムの導入、種々の神経伝達物質の選択的検出、活動電位の高感度検出を目指す。これらにより、神経伝達物質の選択的検出および活動電位の高感度検出を可能とする 新規電気化学センサの開発を目指した。 1年目および2年目では複数の神経伝達物質を同時に評価できる電気化学イメージングデバイスの開発に着手してきた。このデバイスでは、選択的に電極に酵素を導入した電極を作成することで、ドーパミンおよびグルタミン酸の同時検出に成功している。 最終年度になる3年目では、これまでに作成してきた新規電化学デバイスの神経伝達物質の検出感度をさらに高感度化するために、シグナル増幅機構および神経伝達物質の選択的検出能を有する電気化学イメージングデバイスの設計、シミュレーションそして作成を行った。作成した新規電気化学イメージングデバイスその結果、2から3倍近く神経伝達物質の検出感度の向上を確認した。また、シミュレーション結果とも一致しており、設計通りのデバイス作成に成功したと言える。本デバイスを用いて神経様細胞塊を評価し、リアルタイムで神経様細胞塊から放出される神経伝達物質の検出に成功した。 これらの成果をまとめ、現在学会発表や国際誌への投稿を行っている。

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メディア報道 6

  1. 神経に柔らかく巻付くオール有機物のゲル電極 ~迷走神経刺激に有用な MRI 対応の電極が実現~

    東北大学

    2022年10月6日

  2. 「貼るワクチン」にマイクロニードルポンプを搭載 ~注射と同等以上の免疫効果を動物実験で確認~

    東北大学

    2022年9月6日

  3. O₂タンク内蔵!ウォータープルーフ仕様のバイオ発電パッチを開発

    東北大学

    2022年8月22日

    メディア報道種別: インターネットメディア

  4. 昆虫の脱皮に学ぶ3次元ゲルプリンティング ~空気とゲルの界面を利用した硬化と表面機能化~

    東北大学

    2021年5月20日

    メディア報道種別: インターネットメディア

  5. 貼る注射「マイクロニードルポンプ」を開発 ~「流れ」を発生するマイクロニードルが薬やワクチンの高速注入を可能に~

    東北大学

    2021年1月28日

  6. 高活性な非白金酸素還元触媒の作製に成功! 安価な燃料電池や金属空気電池の実現に期待

    東北大学 プレスリリース

    2019年10月18日

    メディア報道種別: インターネットメディア

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学術貢献活動 23

  1. Biosensors and Bioelectronics

  2. Small

  3. Sensors and Actuators B: Chemical

  4. Lab on a Chip

  5. ChemCatChem

  6. Chemistry Letters

  7. Analyst

  8. Electroanalysis

  9. Microelectronic Engineering

  10. Applied Physics Express

  11. RSC Advances

  12. Journal of Physics: Energy

  13. ACS Applied Materials and Interfaces

  14. Advanced Materials Interfaces

  15. Advanced sensor research

  16. Analytical sciences

  17. ChemBioChem

  18. ChemElectroChem

  19. Chemistry - An Asian Journal

  20. ChemPhysChem

  21. ChemSusChem

  22. Langmuir

  23. The chemical record

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