Yoshihiro Furukawa Yoshito Chikaraishi Naohiko Ohkouchi Nanako O. Ogawa Daniel P. Glavin Jason P. Dworkin Chiaki Abe Tomoki Nakamura
Proceedings of the National Academy of Sciences of UAS 116(49) 24440-24445 2019年12月 [査読有り]
Sugars are essential molecules for all terrestrial biota working in many biological processes. Ribose is particularly essential as a building block of RNA, which could have both stored information and catalyzed reactions in primitive life on Earth...
According to the RNA World hypothesis, ribonucleic acid (RNA) played a critical role in the origin of life. However, ribose, an essential component of RNA, is easily degraded: finding a way to stabilize it is critical to the viability of the hypot...
Hyo-Joong Kim Yoshihiro Furukawa Takeshi Kakegawa Andrei Bita Romulus Scorei Steven A. Benner
Angewandte Chemie International Edition 55(51) 15816-15820 2016年12月 [査読有り]
RNA is currently thought to have been the first biopolymer to support Darwinian natural selection on Earth. However, the phosphate esters in RNA and its precursors, and the many sites at which phosphorylation might occur in ribonucleosides under c...
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