顔写真

ミズノ サトシ
水野 聖士
Satoshi Mizuno
所属
東北メディカル・メガバンク機構 医療情報ICT部門
職名
助教
学位
  • 博士(医学)(東北大学)

  • 修士(理学)(東京医科歯科大学)

経歴 3

  • 2017年10月 ~ 継続中
    東北大学 東北メディカル・メガバンク機構 医療情報ICT部門 助教

  • 2015年8月 ~ 2017年9月
    東北大学 東北メディカル・メガバンク機構 医療情報ICT部門 助手

  • 2012年7月 ~ 2015年7月
    東北大学大学院 医学系研究科 環境遺伝医学総合研究センター 助手

研究キーワード 3

  • 妊娠高血圧症候群

  • 医療情報学

  • バイオインフォマティクス

研究分野 1

  • 情報通信 / 生命、健康、医療情報学 /

論文 42

  1. Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. 国際誌 査読有り

    Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, Taku Obara, Mami Ishikuro, Hiroshi Tanaka, Kengo Kinoshita, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Soichi Ogishima

    BMC pregnancy and childbirth 23 (1) 628-628 2023年8月31日

    DOI: 10.1186/s12884-023-05919-5  

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    BACKGROUND: Low birth weight (LBW) is a leading cause of neonatal morbidity and mortality, and increases various disease risks across life stages. Prediction models of LBW have been developed before, but have limitations including small sample sizes, absence of genetic factors and no stratification of neonate into preterm and term birth groups. In this study, we challenged the development of early prediction models of LBW based on environmental and genetic factors in preterm and term birth groups, and clarified influential variables for LBW prediction. METHODS: We selected 22,711 neonates, their 21,581 mothers and 8,593 fathers from the Tohoku Medical Megabank Project Birth and Three-Generation cohort study. To establish early prediction models of LBW for preterm birth and term birth groups, we trained AI-based models using genetic and environmental factors of lifestyles. We then clarified influential environmental and genetic factors for predicting LBW in the term and preterm groups. RESULTS: We identified 2,327 (10.22%) LBW neonates consisting of 1,077 preterm births and 1,248 term births. Our early prediction models archived the area under curve 0.96 and 0.95 for term LBW and preterm LBW models, respectively. We revealed that environmental factors regarding eating habits and genetic features related to fetal growth were influential for predicting LBW in the term LBW model. On the other hand, we identified that genomic features related to toll-like receptor regulations and infection reactions are influential genetic factors for prediction in the preterm LBW model. CONCLUSIONS: We developed precise early prediction models of LBW based on lifestyle factors in the term birth group and genetic factors in the preterm birth group. Because of its accuracy and generalisability, our prediction model could contribute to risk assessment of LBW in the early stage of pregnancy and control LBW risk in the term birth group. Our prediction model could also contribute to precise prediction of LBW based on genetic factors in the preterm birth group. We then identified parental genetic and maternal environmental factors during pregnancy influencing LBW prediction, which are major targets for understanding the LBW to address serious burdens on newborns' health throughout life.

  2. Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children's Study. 国際誌 査読有り

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Kaoh Tanoue, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension 46 (4) 834-844 2023年2月3日

    DOI: 10.1038/s41440-022-01144-3  

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    Hypertensive disorders of pregnancy (HDP) are associated with poor maternal and neonatal prognoses. Although several studies have indicated an effect of secondhand smoke (SHS) exposure on HDP, such evidence is lacking in Japan. Therefore, we analyzed data from the Japan Environment and Children's Study, a large-scale epidemiological investigation, to elucidate a possible link between SHS exposure and HDP risk. Data were obtained from the all-birth fixed datasets and included information on 104,062 fetuses and their parents. SHS exposure was assessed in terms of the frequency (rarely, 1-3, or 4-7 days/week) and the daily duration of exposure (<1, 1-2, or ≥2 h(s)/day). Modified Poisson regression model analyses were performed with adjustment for known risk factors for HDP. Additionally, the population attributable fractions (PAFs) of SHS exposure and maternal smoking to HDP prevalence were estimated. The relative risks of developing HDP among individuals with SHS exposures of 4-7 days/week and ≥2 h/day were 1.18 and 1.27 (95% confidence interval: 1.02-1.36 and 0.96-1.67), respectively, compared to the reference groups (rare exposure and <1 h/day). The PAFs for the risk of HDP due to SHS exposure and perinatal smoking were 3.8% and 1.8%, respectively. Japanese women with greater exposure to SHS have a higher risk of HDP after adjustment for possible confounding factors; thus, relevant measures are required to reduce SHS exposure to alleviate HDP risk. The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4-7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.

  3. A knowledge representation model for family relationship to three generation 査読有り

    Kazuro Shimokawa, Mami Ishikuro, Taku Obara, Hirohito Metoki, Satoshi Mizuno, Satoshi Nagaie, Masato Nagai, Chizuru Yamanaka, Hiroko Matsubara, Mayumi Kato, Yuki Sato, Soichi Ogishima, Takako Takai, Masahiro Kikuya, Atsushi Hozawa, Fuji Nagami, Shinichi Kuriyama, Takashi Suzuki, Kengo Kinoshita, Masayuki Yamamoto, Hiroshi Tanaka

    Bioinformation 18 (12) 1166-1172 2022年12月31日

    出版者・発行元:Biomedical Informatics

    DOI: 10.6026/973206300181166  

    ISSN:0973-8894

    eISSN:0973-2063

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    A system for inputting and storing family information, named “BirThree Enrollment,” was developed to promote a birth and three-generation cohort study (BirThree Cohort Study). In this cohort study, it was necessary to satisfy many operational demands while constantly overwriting and changing input information. Complex kinship information must be quickly and accurately inputed and corrected, and information on those families not yet recruited must be retrieved. For these purposes, many devices are needed, from an input interface to the internal data structure. In the field of genetic statistics, a simple standard expressive form (describe father-child relation and mother-child relation) is used for describing family structure. However, this form doesn't have sufficient information. So we developed a new form in conducting the BirThree Cohort Study. Hence, we expanded the data structure, and constructed the Input control system. Family pedigree information is stored along with initial clinical information, and this enabled the input of all self-reported information to the data base. Operators are able to input this family information before the day is out. As a result, when recruitment is completed, family information will be completed concurrently. Therefore, operators can immediately know certain person's family structure. In this model data correction was improved dramatically, and the system was operated successfully. This study is the first report of the method for storing three generations of family data.

  4. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N. Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Michiaki Abe, Yayoi Aizawa, Yuichi Aoki, Koichi Chida, Inaho Danjoh, Shinichi Egawa, Ai Eto, Takamitsu Funayama, Nobuo Fuse, Yohei Hamanaka, Yuki Harada, Hiroaki Hashizume, Shinichi Higuchi, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Atsushi Hozawa, Kazuhiko Igarashi, Jin Inoue, Noriko Ishida, Naoto Ishii, Tadashi Ishii, Mami Ishikuro, Kiyoshi Ito, Sadayoshi Ito, Maiko Kageyama, Fumiki Katsuoka, Hiroshi Kawame, Junko Kawashima, Masahiro Kikuya, Kengo Kinoshita, Kazuyuki Kitatani, Tomomi Kiyama, Hideyasu Kiyomoto, Tomoko Kobayashi, Eiichi Kodama, Mana Kogure, Kaname Kojima, Sachie Koreeda, Seizo Koshiba, Shihoko Koyama, Hisaaki Kudo, Kazuki Kumada, Shigeo Kure, Miho Kuriki, Shinichi Kuriyama, Yoko Kuroki, Norihide Maikusa, Satoshi Makino, Hiroko Matsubara, Hiroyuki Matsui, Hirohito Metoki, Takahiro Mimori, Naoko Minegishi, Kazuharu Misawa, Masako Miyashita, Satoshi Mizuno, Hozumi Motohashi, Ikuko N. Motoike, Satoshi Nagaie, Masato Nagai, Fuji Nagami, Masao Nagasaki, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Naoki Nakaya, Keiko Nakayama, Akira Narita, Ichiko Nishijima, Takahiro Nobukuni, Kotaro Nochioka, Taku Obara, Soichi Ogishima, Noriaki Ohuchi, Gervais Olivier, Noriko Osumi, Hiroshi Otsu, Akihito Otsuki, Daisuke Saigusa, Sakae Saito, Tomo Saito, Masaki Sakaida, Mika Sakurai-Yageta, Yuki Sato, Yukuto Sato, Atsushi Sekiguchi, Chen-Yang Shen, Tomoko F. Shibata, Ritsuko Shimizu, Kazuro Shimokawa, Matsuyuki Shirota, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Shu Tadaka, Makiko Taira, Takako Takai-Igarashi, Yuji Takano, Yasuyuki Taki, Gen Tamiya, Osamu Tanabe, Hiroshi Tanaka, Yukari Tanaka, Shunsuke Teraguchi, Takahiro Terakawa, Teiji Tominaga, Hiroaki Tomita, Akito Tsuboi, Naho Tsuchiya, Ichiro Tsuji, Masao Ueki, Akira Uruno, Nobuo Yaegashi, Junya Yamagishi, Yumi Yamaguchi-Kabata, Chizuru Yamanaka, Riu Yamashita, Jun Yasuda, Junji Yokozawa, Kazunori Waki, Makoto Sasaki, Junko Akai, Ryujin Endo, Akimune Fukushima, Ryohei Furukawa, Tsuyoshi Hachiya, Kouhei Hashizume, Jiro Hitomi, Yasushi Ishigaki, Shohei Komaki, Yuka Kotozaki, Takahiro Mikami, Motoyuki Nakamura, Naoyuki Nishiya, Satoshi Nishizuka, Yoko Nomura, Kuniaki Ogasawara, Hideki Ohmomo, Shinichi Omama, Ryo Otomo, Kotaro Otsuka, Kotaro Oyama, Kiyomi Sakata, Ryohei Sasaki, Mamoru Satoh, Namie Sato, Atsushi Shimizu, Yu Shiwa, Yoichi Sutoh, Nobuyuki Takanashi, Noriko Takebe, Fumitaka Tanaka, Ryoichi Tanaka, Kozo Tanno, Tomoharu Tokutomi, Kayono Yamamoto, Fumio Yamashita, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human Genome Variation 8 (1) 2021年12月

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41439-021-00175-5  

    eISSN:2054-345X

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    <title>Abstract</title>To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  5. Analysis of HLA-G long-read genomic sequences in mother-offspring pairs with preeclampsia. 国際誌

    Ayako Nishizawa, Kazuki Kumada, Keiko Tateno, Maiko Wagata, Sakae Saito, Fumiki Katsuoka, Satoshi Mizuno, Soichi Ogishima, Masayuki Yamamoto, Jun Yasuda, Junichi Sugawara

    Scientific reports 10 (1) 20027-20027 2020年11月18日

    DOI: 10.1038/s41598-020-77081-3  

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    Preeclampsia is a pregnancy-induced disorder that is characterized by hypertension and is a leading cause of perinatal and maternal-fetal morbidity and mortality. HLA-G is thought to play important roles in maternal-fetal immune tolerance, and the associations between HLA-G gene polymorphisms and the onset of pregnancy-related diseases have been explored extensively. Because contiguous genomic sequencing is difficult, the association between the HLA-G genotype and preeclampsia onset is controversial. In this study, genomic sequences of the HLA-G region (5.2 kb) from 31 pairs of mother-offspring genomic DNA samples (18 pairs from normal pregnancies/births and 13 from preeclampsia births) were obtained by single-molecule real-time sequencing using the PacBio RS II platform. The HLA-G alleles identified in our cohort matched seven known HLA-G alleles, but we also identified two new HLA-G alleles at the fourth-field resolution and compared them with nucleotide sequences from a public database that consisted of coding sequences that cover the 3.1-kb HLA-G gene span. Intriguingly, a potential association between preeclampsia onset and the poly T stretch within the downstream region of the HLA-G*01:01:01:01 allele was found. Our study suggests that long-read sequencing of HLA-G will provide clues for characterizing HLA-G variants that are involved in the pathophysiology of preeclampsia.

  6. 日本語版妊娠高血圧腎症オントロジーの開発

    水野 聖士, 和形 麻衣子, 永家 聖, 八重樫 伸生, 菅原 準一, 荻島 創一

    医療情報学 40 (3) 115-124 2020年11月

    出版者・発行元:(一社)日本医療情報学会

    ISSN:0289-8055

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    著者らはこれまでに,国際誌に掲載された原著論文から妊娠高血圧腎症(Preeclampsia:PE)に関する広範囲の重要な概念と語彙を抽出し,概念構造を階層的にまとめた妊娠高血圧腎症オントロジー(Preeclampsia Ontology:PEO)を開発してきた.しかし,PEOに含まれる語彙や概念はこれまでに日本語にローカライゼーションされておらず,日本語で記述された医療情報や文献情報の二次利用への適用ができなかった.そこで,本研究では,複数の辞書を組み合わせた辞書ベースおよび,専門家の知識によるエキスパートベースのローカライゼーションを組み合わせ,PEOのローカライゼーションを行い,日本語版PEOを構築した.日本語版PEOに含まれる語彙は,主に分子情報と表現型に関わるもので構成されており,PEに関連する遺伝子名,化合物名や産科アウトカム,合併症,検査・診断に関する語彙が含まれている.日本語版PEOは,妊娠高血圧腎症に関する広範囲な日本語の語彙を含み,多くの医療情報学的タスクに利用可能であることが期待される.(著者抄録)

  7. Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Junichi Sugawara, Mami Ishikuro, Taku Obara, Tomomi Onuma, Keiko Murakami, Masahiro Kikuya, Fumihiko Ueno, Aoi Noda, Satoshi Mizuno, Tomoko Kobayashi, Yohei Hamanaka, Kichiya Suzuki, Eiichi Kodama, Naho Tsuchiya, Akira Uruno, Yoichi Suzuki, Osamu Tanabe, Hideyasu Kiyomoto, Akito Tsuboi, Atsushi Shimizu, Seizo Koshiba, Naoko Minegishi, Soichi Ogishima, Gen Tamiya, Hirohito Metoki, Atsushi Hozawa, Nobuo Fuse, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology 32 (2) 69-79 2020年10月10日

    DOI: 10.2188/jea.JE20200338  

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    BACKGROUND: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. METHODS: Expectant mothers living in Miyagi prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. RESULTS: A total of 23 406 pregnancies involving 23 730 fetuses resulted in 23 143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes and hypertensive disorders of pregnancy. CONCLUSIONS: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.

  8. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. 国際誌 査読有り

    Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

    Pregnancy hypertension 22 119-125 2020年8月5日

    DOI: 10.1016/j.preghy.2020.08.001  

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    Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.

  9. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. 国際誌

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    International journal of epidemiology 49 (1) 18-19 2020年2月1日

    DOI: 10.1093/ije/dyz169  

  10. Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan Environment and Children's Study. 国際誌 査読有り

    Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 33 (3) 427-436 2020年2月

    DOI: 10.1080/14767058.2018.1494712  

    ISSN:1476-7058

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    Objective: To provide the latest and most promising evidence on the prevalence and determinants for folic acid supplementation in pregnant women in Japan, including differences in prevalence between interview years and determinants across regions.Materials and methods: The study participants were enrolled from 15 regional centers across Japan between January 2011 and March 2014. Information on the use of folic acid supplementation before and during pregnancy and the characteristics of the participants were collected using questionnaires, medical chart reviews, and interviews by research coordinators.Results: Data for 91,538 women who provided sufficient data on folic acid supplementation were analyzed. The prevalence of adequate users was 8.0%, which, although low, tended to improve over the 4-year recruitment period. Various kinds of sociodemographic factors, lifestyle habits, and obstetrical and medication use history were significant and independent determinants for folic acid use. Associations between adequate preconception folic acid use and its major determinants tended to be similar across regions.Conclusions: Although the prevalence of adequate folic acid use was low, it increased from 2011 to 2014. Reproductive-aged women who have determinants for inadequate folic acid use should be informed about the need for preconception folic acid supplementation to help prevent neural tube defects.

  11. Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children's Study. 国際誌 査読有り

    Kaou Tanoue, Hidekazu Nishigori, Zen Watanabe, Kosuke Tanaka, Kasumi Sakurai, Satoshi Mizuno, Mami Ishikuro, Taku Obara, Masahito Tachibana, Tetsuro Hoshiai, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Journal of interpersonal violence Epub ahead of print (21-22) 886260519881517-886260519881517 2019年10月16日

    DOI: 10.1177/0886260519881517  

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    This study aimed to clarify the interannual changes in intimate partner violence against pregnant women after the March 11, 2011 Great East Japan Earthquake in target areas of Miyagi Prefecture that were damaged by the earthquake and tsunami. Because of this disaster, in Miyagi Prefecture, approximately 12,000 people died or went missing, and approximately 238,000 buildings were destroyed. According to the U.S. Geological Survey, the Great East Japan Earthquake is the fourth largest earthquake in the world and the largest in Japan since 1900. The present study was part of the Japan Environment and Children's Study. Data from June 2011 to May 2014 of 79,222 pregnant women were analyzed, calculating the prevalence of physical and mental intimate partner violence in the inland, north coastal, and south coastal areas of Miyagi. These prevalence rates were compared with nationwide rates of intimate partner violence in 2011 using univariate and logistic regression analyses. After the disaster, the incidence of mental intimate partner violence increased in the south coastal area and then improved later (19.4%, 13.1%, and 13.3% for south coastal area, and 13.8%, 13.8%, and 13.1% for nationwide in 2011, 2012, and 2013, respectively). However, in the north coastal area, the incidence of physical intimate partner violence increased after the disaster and then improved later (2.7%, 1.5%, and 1.3% for north coastal area, and 1.4%, 1.3%, and 1.1% for nationwide in 2011, 2012, and 2013, respectively). In the inland area, however, the prevalence of both mental and physical intimate partner violence was consistently higher than nationwide rates after the disaster.

  12. Mother-to-infant bonding failure and intimate partner violence during pregnancy as risk factors for father-to-infant bonding failure at 1 month postpartum: an adjunct study of the Japan Environment and Children's Study. 国際誌 査読有り

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 33 (16) 1-8 2019年4月15日

    DOI: 10.1080/14767058.2018.1560414  

    ISSN:1476-7058

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    OBJECTIVE: To survey the frequency and risk factors for father-to-infant lack of affection (LA) and anger/rejection (AR) bonding failure at 1 month postpartum. MATERIAL AND METHODS: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment & Children's Study. Bonding failure, psychological distress during pregnancy and postnatal depression symptoms were evaluated using the Japanese version of the Mother-Infant Bonding Scale (MIBS-J), the Kessler 6-item (K6) psychological distress scale and the Edinburgh Postnatal Depression Scale (EPDS-J). This study extracted relative factors based on approximately 10% occupancy of the total high scores in MIBS-J subscales as a cut-off for bonding failure. The cut-off scores on the paternal EPDS-J were eight, on maternal EPDS-J was 9, and on the K6 psychological distress scale score was 13. RESULTS: A total of 1008 couples who had single delivery were assessed at 1 month postpartum, respectively. The prevalence of paternal MIBS-J_LA scores ≥4 was 8.3%, MIBS-J_AR scores ≥3 was 7.9%, and EPDS-J scores ≥8 was 11.2%, respectively. In the multiple logistics analysis, paternal MIBS-J_LA scores ≥4 were significantly associated with maternal MIBS-J_LA score ≥3 (adjusted odds ratio (AOR) 2.814; 95% confidence interval (CI): 1.377-5.747), mental intimate partner violence (IPV) against the mother during pregnancy (AOR 2.176; 95% CI: 1.185-3.997), maternal K6 psychological distress scale score ≥13 (AOR 2.980; 95% CI: 1.317-6.745), paternal EPDS-J score ≥8 (AOR 3.227; 95% CI: 1.767-5.892), and a history of mental health disorder (AOR 4.125; 95% CI: 1.423-11.963). Paternal MIBS-J_AR scores ≥3 were significantly associated with maternal MIBS-J_AR scores ≥3 (AOR 5.082; 95% CI: 2.453-10.529), a history of physical IPV against the mother during pregnancy (AOR 5.230; 95% CI: 1.016-26.920), paternal K6 psychological distress scale score ≥13 (AOR 4.145; 95% CI: 1.311-13.107), and paternal EPDS-J scores ≥8 (AOR 4.479; 95% CI: 2.503-8.013). In Pearson's product moment correlation coefficient analyses between paternal and maternal MIBS-J score, MIBS-J_LA score was r = 0.2112, p < .0001, and MIBS-J_AR score was r = 0.3281, p < .0001. CONCLUSION: Father-to-infant lack of affection bonding failure was associated with mother-to-infant lack of affection bonding failure, mental IPV against mother during pregnancy, maternal psychological distress during pregnancy, paternal postpartum depression symptoms, and history of paternal mental health disorders. Father-to-infant anger/rejection bonding failure was associated with mother-to-infant anger/rejection bonding failure, physical IPV against mother during pregnancy, paternal psychological distress during pregnancy, and paternal postpartum depression symptoms. Since bonding failure is a risk factor for infant maltreatment, further investigations are recommended to fully assess these associations to resolve parent perinatal mental health issues for preventing father-to-infant bonding failure.

  13. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. 国際誌 査読有り

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Hirotaka Hamada, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension 42 (4) 558-566 2019年4月

    DOI: 10.1038/s41440-019-0206-x  

    ISSN:0916-9636

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    Smoking during pregnancy is a risk factor for various adverse birth outcomes but lowers the risk of preeclampsia. Cardiovascular adaptations might underlie these associations. We examined the association of maternal smoking with the risk of hypertensive disorders of pregnancy (HDP) in a low-risk population-based cohort of 76,303 pregnant women. This study was a part of the Japan Environment and Children's Study. Smoking status was assessed using questionnaires completed by participants. Information about HDP was assessed using questionnaires completed by doctors. Compared with that for women who did not smoke, women who continued smoking >10 cigarettes per day during pregnancy had a significantly higher risk of developing HDP (odds ratio: 1.58, 95% confidence interval: 1.11-2.25). In multivariate analyses with adjustment for possible confounding factors, the association still remained (odds ratio: 1.51, 95% confidence interval: 1.04-2.19). When we regarded the number of cigarettes as a continuous variable, there was a linear association between the number of cigarettes and risk of HDP, with an odds ratio of 1.02 per cigarette per day (95% confidence interval: 1.00-1.04). Smoking a greater number of cigarettes was associated with a higher risk of HDP after adjustment for possible confounding factors. Cigarette smoking cessation may avoid the complications of HDP. Our findings suggest that, in addition to the risk of small-for-gestational-age children, an increased risk of HDP should be considered in the management of pregnant women who smoke cigarettes.

  14. The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. 国際誌 査読有り

    Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima

    Reproductive biology and endocrinology : RB&E 17 (1) 27-27 2019年2月22日

    DOI: 10.1186/s12958-019-0471-1  

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    BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. METHODS: The Japan Environment and Children's Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. RESULTS: For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage embryo transfer vs. blastocyst transfer), the percentages of males were 51.3% vs 50.7% vs 48.9% vs 53.4% and the monozygotic twinning rates per pregnancy were 0.27% vs 0.11% vs 0.27% vs 0.99% respectively. Multivariate logistic regression analyses indicated that blastocyst transfer was significantly associated with a higher SSR and higher incidence of MZT than the other three groups (SSR: AOR 1.095, 95% CI1.001-1.198; MZT: AOR 4.229, 95% CI 2.614-6.684). CONCLUSIONS: There are significant relationships between blastocyst transfer and SSR imbalance and a higher occurrence of MZT.

  15. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. 国際誌 査読有り

    Zen Watanabe, Hidekazu Nishigori, Kaou Tanoue, Kosuke Tanaka, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Ikuma Fujiwara, Takahiro Arima, Takashi Takeda, Shinichi Kuriyama, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Journal of affective disorders 245 475-483 2019年2月15日

    DOI: 10.1016/j.jad.2018.11.061  

    ISSN:0165-0327

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    BACKGROUND: Dysmenorrhea influences emotional distress as well as physical suffering in young non-pregnant women. The aim of this study was to assess the potential association between preconception dysmenorrhea and the development of psychological distress during pregnancy. METHODS: This study was a part of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study conducted between 2011 and 2014 in Japan. A total of 87,102 pregnant Japanese women with no psychological distress (Kessler 6-item psychological distress scale [K6] score ≤ 12) in early pregnancy were eligible. Among these, 7626 had mild and 1638 had severe preconception dysmenorrhea. The prevalence and risk of maternal psychological distress (K6 scores ≥ 13) in the second or third trimester were compared among preconception dysmenorrhea severity groups. RESULTS: A higher percentage of women with mild (2.6%) or severe preconception dysmenorrhea (3.6%) suffered psychological distress during pregnancy compared to that in women without dysmenorrhea (2.1%). A multilevel logistic regression model, adjusting for baseline characteristics and the K6 score at enrollment, showed that the severity of dysmenorrhea was associated with psychological distress (mild dysmenorrhea: adjusted odds ratio [aOR], 1.154; 95% confidence interval [95% CI], 0.980-1.359; and severe dysmenorrhea: aOR, 1.457; 95% CI, 1.087-1.951). LIMITATIONS: Information about dysmenorrhea was obtained during early pregnancy. The JECS did not have clear diagnostic criteria for dysmenorrhea. CONCLUSIONS: Preconception dysmenorrhea is associated with an elevated incidence of psychological distress during pregnancy. Additionally, expectant mothers with a history of severe dysmenorrhea symptoms before pregnancy have a higher risk of developing psychological distress.

  16. The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment &amp; Children's Study. 国際誌 査読有り

    Nishigori H, Obara T, Nishigori T, Metoki H, Mizuno S, Ishikuro M, Sakurai K, Hamada H, Watanabe Z, Hoshiai T, Arima T, Nakai K, Kuriyama S, Yaegashi N, Miyagi Regional, Center of, Japan Environment, Children’s Study Group

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 33 (16) 1-8 2019年1月4日

    DOI: 10.1080/14767058.2018.1560415  

    ISSN:1476-7058

  17. Management of family relationship information for a three-generation cohort study

    Shimokawa K, Ishikuro M, Obara T, Metoki H, Mizuno S, Nagaie S, Nagai M, Yamanaka C, Matsubara H, Kato M, Sato Y, Ogishima S, Takai-Igarashi T, Kikuya M, Hozawa A, Nagami F, Kuriyama S, Kinoshita K, Yamamoto M, Tanaka H

    bioRxiv 2019年1月

  18. Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. 国際誌 査読有り

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Journal of hypertension 37 (1) 206-215 2019年1月

    DOI: 10.1097/HJH.0000000000001846  

    ISSN:0263-6352

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    OBJECTIVES: Although a twin pregnancy is a risk factor for hypertensive disorders of pregnancy, studies investigating longitudinal blood pressure changes during twin pregnancies are uncommon. The aims of this study were to evaluate the longitudinal blood pressure changes during twin pregnancies and to compare blood pressure levels between twin and singleton pregnancies. METHODS: Five hundred dichorionic diamniotic twin, 240 monochorionic diamniotic twin, and 80 775 singleton pregnancies were included in this Japanese prospective birth cohort study. A marginal model was applied to evaluate the SBP, DBP, and mean arterial pressure levels during early gestation, mid-gestation, and late gestation. RESULTS: The blood pressure levels fell from early-to-mid-gestation and rose after mid-gestation in the dichorionic and monochorionic diamniotic twin pregnancies. The SBP and mean arterial pressure levels during early gestation and the DBP and mean arterial pressure levels during late gestation were higher in the dichorionic diamniotic twin pregnancies than those in the singleton pregnancies. The blood pressure levels in the monochorionic diamniotic twin pregnancies were higher than those in the singleton pregnancies at each gestational stage, except for the SBP during late gestation. CONCLUSION: Although the longitudinal blood pressure changes during twin pregnancies were similar to those during singleton pregnancies, the blood pressure levels during twin pregnancies were higher. Further studies that examine the associations between the longitudinal blood pressure changes during pregnancy and the perinatal outcomes in twin pregnancies are necessary.

  19. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study. 国際誌 査読有り

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Hypertension research : official journal of the Japanese Society of Hypertension 42 (1) 85-94 2019年1月

    DOI: 10.1038/s41440-018-0124-3  

    ISSN:0916-9636

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    This study examined the association between maternal alcohol consumption during pregnancy and hypertensive disorders of pregnancy in the Japan Environment and Children's Study, a nationwide birth cohort study. A total of 76 940 pregnant women were included in the analysis. Information about alcohol consumption during pregnancy was obtained using two questionnaires: T1 and T2. The mean (standard deviation) gestational age in the T1 and T2 questionnaires were 16.5 (5.8) and 27.9 (3.7) weeks, respectively. Alcohol consumption was considered as an exposure, hypertensive disorders of pregnancy as an outcome, and possible confounding factors were included in a generalized linear mixed-effects model with a logit link function. Among the study subjects, 2 348 (3.1%) women developed hypertensive disorders of pregnancy. Compared with 25 300 women who never drank alcohol, 43 women who drank alcohol according to the T1 questionnaire and continued to drink ≥150 g ethanol/week according to the T2 questionnaire had significantly higher odds of hypertensive disorders of pregnancy. The adjusted odds ratio was 3.98 (95% confidence interval [CI], 1.33-11.9). In conclusion, alcohol consumption of ≥150 g ethanol/week during pregnancy is better avoided because of the high odds of developing hypertensive disorders of pregnancy. It may be meaningful that healthcare providers confirm information about alcohol consumption during pregnancy. Moreover, discontinuation of alcohol consumption is recommended to prevent the onset of hypertensive disorders of pregnancy in Japan.

  20. Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods. 国際誌 査読有り

    Taku Obara, Mami Ishikuro, Gen Tamiya, Masao Ueki, Chizuru Yamanaka, Satoshi Mizuno, Masahiro Kikuya, Hirohito Metoki, Hiroko Matsubara, Masato Nagai, Tomoko Kobayashi, Machiko Kamiyama, Mikako Watanabe, Kazuhiko Kakuta, Minami Ouchi, Aki Kurihara, Naru Fukuchi, Akihiro Yasuhara, Masumi Inagaki, Makiko Kaga, Shigeo Kure, Shinichi Kuriyama

    Scientific reports 8 (1) 14840-14840 2018年10月4日

    DOI: 10.1038/s41598-018-33110-w  

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    We investigated whether machine learning methods could potentially identify a subgroup of persons with autism spectrum disorder (ASD) who show vitamin B6 responsiveness by selected phenotype variables. We analyzed the existing data from our intervention study with 17 persons. First, we focused on signs and biomarkers that have been identified as candidates for vitamin B6 responsiveness indicators. Second, we conducted hypothesis testing among these selected variables and their combinations. Finally, we further investigated the results by conducting cluster analyses with two different algorithms, affinity propagation and k-medoids. Statistically significant variables for vitamin B6 responsiveness, including combination of hypersensitivity to sound and clumsiness, and plasma glutamine level, were included. As an a priori variable, the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) scores was also included. The affinity propagation analysis showed good classification of three potential vitamin B6-responsive persons with ASD. The k-medoids analysis also showed good classification. To our knowledge, this is the first study to attempt to identify subgroup of persons with ASD who show specific treatment responsiveness using selected phenotype variables. We applied machine learning methods to further investigate these variables' ability to identify this subgroup of ASD, even when only a small sample size was available.

  21. Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. 査読有り

    Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

    The Tohoku journal of experimental medicine 246 (2) 97-105 2018年10月

    DOI: 10.1620/tjem.246.97  

    ISSN:0040-8727

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    Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.

  22. Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study. 国際誌 査読有り

    Hisashi Ohseto, Mami Ishikuro, Masahiro Kikuya, Taku Obara, Yuko Igarashi, Satomi Takahashi, Daisuke Kikuchi, Michiko Shigihara, Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

    Journal of psychosomatic research 107 20-25 2018年4月

    DOI: 10.1016/j.jpsychores.2018.01.013  

    ISSN:0022-3999

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    OBJECTIVE: Metabolic syndrome and the presence of metabolic syndrome components are risk factors for cardiovascular disease (CVD). However, the association between personality traits and metabolic syndrome remains controversial, and few studies have been conducted in East Asian populations. METHODS: We measured personality traits using the Japanese version of the Eysenck Personality Questionnaire (Revised Short Form) and five metabolic syndrome components-elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose-in 1322 participants aged 51.1±12.7years old from Kakegawa city, Japan. Metabolic syndrome score (MS score) was defined as the number of metabolic syndrome components present, and metabolic syndrome as having the MS score of 3 or higher. We performed multiple logistic regression analyses to examine the relationship between personality traits and metabolic syndrome components and multiple regression analyses to examine the relationship between personality traits and MS scores adjusted for age, sex, education, income, smoking status, alcohol use, and family history of CVD and diabetes mellitus. We also examine the relationship between personality traits and metabolic syndrome presence by multiple logistic regression analyses. RESULTS: "Extraversion" scores were higher in those with metabolic syndrome components (elevated waist circumference: P=0.001; elevated triglycerides: P=0.01; elevated blood pressure: P=0.004; elevated fasting glucose: P=0.002). "Extraversion" was associated with the MS score (coefficient=0.12, P=0.0003). No personality trait was significantly associated with the presence of metabolic syndrome. CONCLUSIONS: Higher "extraversion" scores were related to higher MS scores, but no personality trait was significantly associated with the presence of metabolic syndrome.

  23. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren 査読有り

    Miyashita M, Ishikuro M, Kikuya M, Yamanaka C, Mizuno S, Nagai M, Sato Y, Obara T, Metoki H, Kikuchi A, Nakaya N, Hozawa A, Tsuji I, Yaegashi N, Yamamoto M, Kure S, Kuriyama S

    Journal of Pediatrics and Congenital Disorders 4 101 2017年7月

  24. Pregnant Women's Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children's Study 査読有り

    Hidekazu Nishigori, Toshie Nishigori, Kasumi Sakurai, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Zen Watanabe, Noriyuki Iwama, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Shinichi Kuriyama, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Fumiaki Takahashi, Nobuo Yaegashi

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS 11 (3) 355-364 2017年6月

    出版者・発行元:CAMBRIDGE UNIV PRESS

    DOI: 10.1017/dmp.2016.150  

    ISSN:1935-7893

    eISSN:1938-744X

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    Objective We aimed to clarify the correlation between the 2011 Great East Japan Earthquake and pregnant women's awareness of social capital 3 to 9 months after the tsunami disaster. Methods We analyzed data on responses to a questionnaire by 7451 pregnant women in their second to third trimesters. The proportions of social capital-related items were calculated in the north and south coastal areas of Miyagi Prefecture and were compared with national samples. The factors associated with social capital were estimated by use of multivariate logistic regression analyses. Results The proportion of women feeling that they had helpful neighbors was higher (69.0% vs 56.7%, P=0.0005), the proportion of women regarding their communities as safe and secure was lower (51.7% vs 62.4%, P=0.002), and the proportion of women feeling that most people were trustworthy was lower (23.7% vs 32.9%, P=0.006) in the north coastal area than nationwide. Such differences were not observed in the less severely affected south coastal area. Age of 35 years or older, extended family, college or university graduation, and being multiparous were associated with the feeling of having helpful neighbors. Conclusion The current status of pregnant women's awareness of social capital in disaster-affected areas was revealed. Continuous monitoring and support may be necessary to address this issue.(Disaster Med Public Health Preparedness. 2017;11:355-364)

  25. Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study 査読有り

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Satoshi Mizuno, Hirohito Metoki, Tetsuro Hoshiai, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    CONGENITAL ANOMALIES 57 (3) 72-78 2017年5月

    出版者・発行元:WILEY

    DOI: 10.1111/cga.12202  

    ISSN:0914-3505

    eISSN:1741-4520

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    We analyzed data from the Japan Environment and Children's Study (JECS), on the association between selective serotonin reuptake inhibitors (SSRI) use during pregnancy and the risk of developing of major congenital anomalies in Japan. JECS is an ongoing nationwide birth cohort study. The study includes 95994 single pregnant women and their offspring. Among them, 172 used any SSRI up to the 12(th) gestational week. Crude analyses show a significantly increased incidence of upper limb, abdominal, and urogenital abnormalities. In particular, the incidence of microcephaly, hydrencephalus, esophageal atresia, small intestinal atresia, and achondroplasia was significantly higher with than without exposure to these substances. On multivariate analyses, urogenital abnormality was significant (odds ratio 3.227; 95% confidence interval: 1.460-7.134). This Japanese nationwide birth cohort survey clarified that the use of any SSRI until the 12(th) gestational week was associated with urogenital abnormality in children. The survey for association with minor classification abnormality needs further examination in Japan.

  26. Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study. 国際誌 査読有り

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi

    Pharmacy (Basel, Switzerland) 5 (2) 2017年4月10日

    DOI: 10.3390/pharmacy5020021  

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    Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78.4%, 57.1%, and 68.8% respectively. Excluding iron supplements, folic acid, and other vitamins and minerals, the percentages of women taking supplements were 75.3%, 36.0%, and 51.7% at each respective time point. The following drugs and supplements were frequently used for 12 months before pregnancy diagnosis: Commercially available antipyretics, analgesics, and/or medicine for treating common cold (34.7%), antipyretics, analgesics, and/or medicine for treating common colds, which were prescribed in hospitals (29.8%), antimicrobial drugs (14.0%), and anti-allergy drugs (12.5%). The following drugs and supplements were frequently used from the time of pregnancy diagnosis until week 12 of pregnancy, and after week 12 of pregnancy: folic acid (28.9% and 26.2%), antipyretics, analgesics and/or medicines for treating common cold, that were prescribed in hospitals (7.8% and 13.3%), Chinese herbal medicines (6.0% and 9.4%, and uterine relaxants (5.1% and 15.2%). Conclusions: The analysis of a nationwide cohort study showed that a high percentage of Japanese pregnant women were taking medicinal drugs. Further research is required to elucidate the relationship between drug use during pregnancy and birth defects in Japan.

  27. Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children's Study 査読有り

    Kasumi Sakurai, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Fumiaki Takahashi, Kunihiko Nakai, Nobuo Yaegashi

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS 11 (2) 216-226 2017年4月

    出版者・発行元:CAMBRIDGE UNIV PRESS

    DOI: 10.1017/dmp.2016.109  

    ISSN:1935-7893

    eISSN:1938-744X

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    Objective: This study aimed to clarify the correlation between the 2011 Great East Japan Earthquake and domestic violence (DV) against pregnant females after the disaster in Miyagi Prefecture, an area damaged by the earthquake and tsunami. Methods: We analyzed 7600 pregnant females from June to December 2011. The incidence of physical and mental DV and the proportions in the inland, north coastal, and south coastal areas of Miyagi Prefecture and nationwide were calculated, and a chi-square test was conducted for comparison. The risk factors for DV were estimated with multivariate logistic regression analyses on a prefecture-wide basis. Results: The incidence levels for physical DV were found to be 5.9% in the north coastal area, which was significantly higher than in the inland area (1.3%, P=0.0007) and nationwide (1.5%, P&lt;0.0001). There were no significant differences in the incidence of mental DV between the 3 areas in Miyagi Prefecture (inland 15.2%, north coast 15.7%, and south coast 18.8%) or nationwide (13.8%). Experiencing disease or injury in someone close and changes in the family structure were significantly associated with mental DV in Miyagi Prefecture. Conclusion: Continuous monitoring and support for pregnant females may be necessary to address this issue in disaster-affected areas.

  28. Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children's Study (JECS) 査読有り

    Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 30 (5) 588-593 2017年3月

    出版者・発行元:TAYLOR & FRANCIS LTD

    DOI: 10.1080/14767058.2016.1179273  

    ISSN:1476-7058

    eISSN:1476-4954

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    Objective: The aim of the study was to clarify the prevalence and determinants of inadequate use of folic acid supplementation in pregnant Japanese women.Methods: This study was part of the Japan Environment and Children's Study, a nationwide and government-funded birth cohort study. We collected information on the use of folic acid supplementation before and during pregnancy and characteristics of participants using self-administered questionnaire.Results: Among 9849 women who completed the data collection for this study, the prevalence of inadequate users was 92.6% of the total population and varied from 84.5% to 96.2% among regions. On the basis of multivariate logistic regression analysis, younger age, not married, lower family income, multipara, natural conception and no history of spontaneous abortion were found to be determinants for inadequate users of folic acid supplementation.Conclusion: Most Japanese pregnant women show inadequate folic acid supplementation use. Japanese women of child-bearing age need to be specifically informed about the need for periconceptional intake of folic acid to prevent neural tube defects.

  29. Determinants of polyunsaturated fatty acid concentrations in erythrocytes of pregnant Japanese women from a birth cohort study: study protocol and baseline findings of an adjunct study of the Japan environment & Children's study 査読有り

    Shoji Saito, Terue Kawabata, Nozomi Tatsuta, Fumiko Kimura, Teruo Miyazawa, Satoshi Mizuno, Hidekazu Nishigori, Takahiro Arima, Yasuo Kagawa, Kouichi Yoshimasu, Kanami Tsuno, Yuki Ito, Michihiro Kamijima, Kunihiko Nakai, Nobuo Yaegashi

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 22 (1) 22 2017年

    出版者・発行元:SPRINGER

    DOI: 10.1186/s12199-017-0636-5  

    ISSN:1342-078X

    eISSN:1347-4715

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    Background: N-3 polyunsaturated fatty acids (n-3 PUFA) may have multiple beneficial effects on the outcome of pregnancy, maternal health and child development. The present study introduced the protocol of a birth cohort study to examine the beneficial effects of n-3 PUFA status in pregnant Japanese women as an adjunct study of the Japan Environment and Children's Study (JECS). Methods: The JECS participants in the coastal areas of Miyagi Prefecture were further invited to participate in this adjunct study, and 1,878 pregnant women were enrolled prior to delivery. Their n-3 PUFA status was evaluated with fatty acid profiles in erythrocytes of maternal blood collected from 1,623 mothers at 24-30 weeks of gestation and cord blood from 1,505 deliveries. Results: The baseline results, including comprehensive data on the fatty acid status and determinants affecting the PUFA status, were analyzed. In stepwise multivariate analyses, the cord blood docosahexaenoic acid (DHA) level was found to be significantly influenced by the DHA level in maternal blood, the child's sex, and the gestational period. The maternal DHA level was influenced by fish intake, maternal age, and the prepregnancy body mass index. While cord blood eicosapentaenoic acid (EPA) was influenced by maternal EPA, fish intake, and season at birth, additional factors such as maternal education, household income, and smoking habits affected the maternal EPA content. Conclusion: Further studies are warranted to clarify the nutritional impacts of n-3 PUFA in pregnant Japanese women of the cohort study.

  30. Fermented Food Consumption and Psychological Distress in Pregnant Women: A Nationwide Birth Cohort Study of the Japan Environment and Children's Study 査読有り

    Fumiaki Takahashi, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Mami Ishikuro, Noriyuki Iwama, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 240 (4) 309-321 2016年12月

    出版者・発行元:TOHOKU UNIV MEDICAL PRESS

    DOI: 10.1620/tjem.240.309  

    ISSN:0040-8727

    eISSN:1349-3329

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    Health benefits of fermented foods are attracting attention worldwide, and they have been traditionally eaten in Japan. Moreover, a recent study showed the association between the higher intake of yogurt and lower prevalence of depressive symptoms during pregnancy. Psychological problems, such as anxiety and depression, during pregnancy are serious health concerns and may increase the risk of adverse outcomes in children. In this study, we explored the association between fermented food consumption and psychological distress in 10,129 pregnant Japanese women, using the fixed data of the Japan Environment and Children's Study (JECS), an ongoing nation-wide birth cohort study. Food consumption was assessed with a semi-quantitative food frequency questionnaire (FFQ), and the Kessler 6-item psychological distress scale (K6) was administered to eligible women during their second or third trimester to eliminate overlap with the period of hyperemesis gravidarum. The mean median gestation in the subjects was 24.8 weeks. In total, 9,030 subjects completed the K6 questionnaire and FFQ. Importantly, the prevalence of the K6 score of 13 was 3.1% (280 subjects). This value was lower compared to precedent studies, which may reflect that cooperative and health conscious subject participated in the survey. The multivariate logistic regression analysis indicates that the intake of yogurt, lactic acid beverages, cheese, Japanese pickles, miso soup, or fermented soybeans was not significantly associated with a K6 score of &gt;= 13. In conclusion, the present cohort study shows no association between fermented food consumption and psychological distress symptoms during the second or third trimester of pregnancy.

  31. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study 査読有り

    Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Fumiaki Takahashi, Noriyuki Iwama, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Kunihiko Nakai, Hidekuni Inadera, Nobuo Yaegashi

    DIABETES RESEARCH AND CLINICAL PRACTICE 120 132-141 2016年10月

    出版者・発行元:ELSEVIER IRELAND LTD

    DOI: 10.1016/j.diabres.2016.07.020  

    ISSN:0168-8227

    eISSN:1872-8227

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    Background: Social capital is generally defined as the quality and frequency of social interactions with relatives, neighbors, and society. Social capital refers to broad concepts of social interactions and structures in individuals, communities and societies such as trust (e.g., neighborhood trust, which is social cohesion with neighbors) and social support (e.g., emotional support, which is the level of the feeling of being loved). Studies during the last few decades have shown that there is a significant inverse association between social capital and the prevalences of diseases such as depression and acute coronary syndrome. Significant inverse associations between trust, social support and the prevalence of diabetes have also been shown. However, associations between social capital and the prevalence of gestational diabetes mellitus (GDM) are less clear. Methods: We used the primary dataset of the Japan Environment and Children's Study (JECS), including 10,228 mothers with recorded obstetric outcomes from January to December 2011. In this study, we included 8874 the 10,228 participants. Diagnosis of GDM was determined using the criteria of the Japan Diabetes Society (JDS). The quality and quantity of social capital were measured with nine questions on a self-administered questionnaire during the second or third trimester. Using principal component analysis (PCA), we distinguished the following three components (indices) of social capital: (A) index of all nine questions about social capital, (B) index of emotional support and neighborhood trust and (C) index of generalized trust. The high factor loading variants of indices were as follows; (A) all nine variants, (B) five variants about emotional support and neighborhood trust and (C) two variants about generalized trust. Multivariate random effect modeling was used to calculate the odd ratios (ORs) for evaluating the association between these indices of social capital and the prevalence of GDM. This model was adjusted for baseline characteristics such as family income, BMI before pregnancy and smoking during pregnancy. Results: Of the 8874 participants, 204 women developed GDM (2.30%). Multivariable logistic regression analysis showed that index B, the index of emotional support and neighborhood trust (adjusted OR: 0.651, 95% CI: 0.429, 0.987) was significantly and independently associated with the prevalence of GDM. Conclusions: We found that the 5-question index of emotional support and neighborhood trust is significantly associated with the prevalence of GDM during pregnancy. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

  32. The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia 査読有り

    Satoshi Mizuno, Soichi Ogishima, Hidekazu Nishigori, Daniel G. Jamieson, Karin Verspoor, Hiroshi Tanaka, Nobuo Yaegashi, Jun Nakaya

    PLoS One 11 (10) e0162828 2016年10月

    出版者・発行元:PUBLIC LIBRARY SCIENCE

    DOI: 10.1371/journal.pone.0162828  

    ISSN:1932-6203

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    Pre-eclampsia (PE) is a clinical syndrome characterized by new-onset hypertension and proteinuria at &gt;= 20 weeks of gestation, and is a leading cause of maternal and perinatal morbidity and mortality. Previous studies have gathered abundant data about PE such as risk factors and pathological findings. However, most of these data are not semantically structured. Clinical data on PE patients are often generated with semantic heterogeneity such as using disparate terminology to describe the same phenomena. In clinical studies, interoperability of heterogenic clinical data is required in various situations. In such a situation, it is necessary to develop an interoperable and standardized semantic framework to research the pathology of PE more comprehensively and to achieve interoperability of heterogenic clinical data of PE patients. In this study, we developed an ontology representing clinical features, treatments, genetic factors, environmental factors, and other aspects of the current knowledge in the domain of PE. We call this pre-eclampsia ontology "PEO". To achieve interoperability with other ontologies, the core structure of PEO was compliant with the hierarchy of the Basic Formal Ontology (BFO). The PEO incorporates a wide range of key concepts and terms of PE from clinical and biomedical research in structuring the knowledge base that is specific to PE; therefore, PEO is expected to enhance PE-specific information retrieval and knowledge discovery in both clinical and biomedical research fields.

  33. Pregnant Women Had the Risk of Psychological Distress in Miyagi After the Great East Japan Earthquake: The Japan Environment and Children's Study (JECS). 査読有り

    Zen Watanabe, Hirohito Metoki, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES 23 186A-186A 2016年3月

    出版者・発行元:SAGE PUBLICATIONS INC

    ISSN:1933-7191

    eISSN:1933-7205

  34. Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease 査読有り

    Satoshi Mizuno, Soichi Ogishima, Kazuyuki Kitatani, Masataka Kikuchi, Hiroshi Tanaka, Nobuo Yaegashi, Jun Nakaya

    PLOS ONE 11 (2) e0148431 2016年2月

    出版者・発行元:PUBLIC LIBRARY SCIENCE

    DOI: 10.1371/journal.pone.0148431  

    ISSN:1932-6203

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    Alzheimer's disease (AD) is the most common cause of senile dementia. Many inflammatory factors such as amyloid-beta and pro-inflammatory cytokines are known to contribute to the inflammatory response in the AD brain. Sphingolipids are widely known to have roles in the pathogenesis of inflammatory diseases, where the precise roles for sphingolipids in inflammation-associated pathogenesis of AD are not well understood. Here we performed a network analysis to clarify the importance of sphingolipids and to model relationships among inflammatory factors and sphingolipids in AD. In this study, we have updated sphingolipid signaling and metabolic cascades in a map of AD signaling networks that we named "AlzPathway," a comprehensive knowledge repository of signaling pathways in AD. Our network analysis of the updated AlzPathway indicates that the pathways related to ceramide are one of the primary pathways and that ceramide is one of the important players in the pathogenesis of AD. The results of our analysis suggest the following two prospects about inflammation in AD: (1) ceramide could play important roles in both inflammatory and anti-inflammatory pathways of AD, and (2) several factors such as Sphingomyelinase and Siglec-11 may be associated with ceramide related inflammation and anti-inflammation pathways in AD. In this study, network analysis of comprehensive knowledge repository reveals a dual role for ceramide in AD. This result provides a clue to clarify sphingolipids related inflammatory and anti-inflammatory pathways in AD.

  35. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study 査読有り

    Zen Watanabe, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

    JOURNAL OF AFFECTIVE DISORDERS 190 341-348 2016年1月

    出版者・発行元:ELSEVIER SCIENCE BV

    DOI: 10.1016/j.jad.2015.10.024  

    ISSN:0165-0327

    eISSN:1573-2517

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    Objective: To examine psychological distress among pregnant women in Miyagi prefecture which was directly affected by the Great East Japan Earthquake and tsunami and compare other areas of Japan that were less damaged. Methods: This study was conducted in conjunction with the Japan Environment and Children's Study (JECS). We examined 10,129 Japanese women using the primary fixed data of the JECS. The Kessler 6-item psychological distress scale (K6) was administered to 7473 eligible women including 998 in Miyagi unit center ('Miyagi UC') and 6475 in the other unit centers ('13UC5'). We compared the prevalence and the risk of distress (K6 &gt;13) during pregnancy in 'Miyagi UC' and '13UC5'. Results: More women in 'Miyagi UC' (4.9%) suffered psychological distress, compared with '13UC5' (3.1%) (p &lt;0.001). A significantly higher prevalence of women in 'Miyagi UC' (55.5%) had experienced negative life events, whereas '13UCs' showed 42.7% (p &lt; 0.0001). In multivariable logistic analyses adjusted for baseline characteristics, there was a significant regional difference of psychological distress (adjusted odds ratio; aOR in Miyagi UC= 1.488; 95%CI, 1.059-2.090). After further adjusting for negative life events, the association was diminished (aOR=1.338; 95%Cl, 0.949-1.884). Limitations: The JECS had no data before the earthquake and the extent of damage was not investigated. Possible regional representativeness is also a limitation. Conclusion: After the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress (K6 &gt;= 13) were high in Miyagi prefecture. Especially in the coastal area directly affected by tsunami, it is high with or without negative life events experienced. (C) 2015 Elsevier BY. All rights reserved.

  36. Alzpathway, an updated map of curated signaling pathways: Towards deciphering Alzheimer's disease pathogenesis 査読有り

    Soichi Ogishima, Satoshi Mizuno, Masataka Kikuchi, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka, Jun Nakaya

    Systems Biology of Alzheimer's Disease 1303 423-432 2015年8月2日

    出版者・発行元:Springer New York

    DOI: 10.1007/978-1-4939-2627-5_25  

    ISSN:1064-3745

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    Alzheimer's disease (AD) is a complex neurodegenerative disorder in which loss of neurons and synaptic function causes dementia in the elderly. To clarify AD pathogenesis and develop drugs for AD, thousands of studies have elucidated signaling pathways involved. However, knowledge of AD signaling pathways has not been compiled as a pathway map. In this chapter, we introduce the manual construction of a pathway map in AD which we call "AlzPathway", that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built the AD pathway map. AlzPathway is currently composed of thousands of molecules and reactions in neurons, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells, with their cellular localizations. AlzPathway provides a systems-biology platform of comprehensive AD signaling and related pathways which is expected to contribute to clarification of AD pathogenesis and AD drug development.

  37. Network-based analysis for uncovering mechanisms underlying Alzheimer's disease 査読有り

    Masataka Kikuchi, Soichi Ogishima, Satoshi Mizuno, Akinori Miyashita, Ryozo Kuwano, Jun Nakaya, Hiroshi Tanaka

    Systems Biology of Alzheimer's Disease 1303 479-491 2015年8月2日

    出版者・発行元:Springer New York

    DOI: 10.1007/978-1-4939-2627-5_29  

    ISSN:1064-3745

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    Alzheimer's disease (AD) is known to be a multifactorial neurodegenerative disorder, and is one of the main causes of dementia in the elderly. Many studies have demonstrated molecules involved in the pathogenesis of AD, however its underlying mechanisms remain obscure. It may be simplistic to try to explain the disease based on the role of a few genes only. Accumulating new, huge amount of information from e.g. genome, proteome and interactome datasets and new knowledge, we are now able to clarify and characterize diseases essentially as a result of dysfunction of molecular networks. Recent studies have indicated that relevant genes affected in human diseases concentrate in a part of the network, often called as "disease module." In the case of AD, some disease-associated pathways seem different, but some of them are clearly disease-related and coherent. This suggests the existence of a common pathway that negatively drives from healthy state to disease state (i.e., the disease module(s)). Additionally, such disease modules should dynamically change through AD progression. Thus, network-level approaches are indispensable to address unknown mechanisms of AD. In this chapter, we introduce network strategies using gene co-expression and protein interaction networks.

  38. Heterogeneity of the Fatty Acid Composition of Japanese Placentae for Determining the Perinatal Fatty Acid Status: a Methodological Study 査読有り

    Isao Yamazaki, Fumiko Kimura, Kiyotaka Nakagawa, Kunihiko Nakai, Takahiro Arima, Terue Kawabata, Yasuo Kagawa, Shoji Saitoh, Satoshi Mizuno, Nobuo Yaegashi, Teruo Miyazawa

    JOURNAL OF OLEO SCIENCE 64 (8) 905-914 2015年8月

    出版者・発行元:JAPAN OIL CHEMISTS SOC

    DOI: 10.5650/jos.ess15071  

    ISSN:1345-8957

    eISSN:1347-3352

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    Analysis of the placenta can be a useful way to determine the fatty acid (FA) status of pregnant women and neonates since this large organ can be obtained easily and non-invasively. Although several studies have been conducted on using placental tissue for FA analysis, the sampling methods have not been thoroughly examined. The aim of the present study was to determine a suitable method of sampling human placentae by focusing on their heterogeneity. Twenty-four placentae were collected from healthy pregnant Japanese women in the Miyagi Prefecture of Japan. Five of them were used to compare the FA composition between the peripheral area and the central area of the placentae. The other 19 were examined to determine differences in the FA composition between the fetal and maternal side. Placental tissue crude lipid was saponified, and methyl was esterified with 14% sodium boron trifluoride methanol for gas chromatography with flame ionization detector analysis. Fifty-six peaks were detected from the methyl esters of the placental total lipid, and 33 of those were identified as FA methyl esters. There were considerable variations in the FA composition, as the variation was low in the central parts and high in the peripheral parts of the placentae. The 18:1n-9 and 18:2n-6 levels were higher in the fetal side, whereas the 20:3n-6, 20:4n-6, and 22:6n-3 levels were higher in the maternal side. These findings indicate the presence of heterogeneity in the FA composition of human placenta, and they suggest the necessity for standardizing the sampling method so that the placental tissue can be used to determine the FA status.

  39. Application of Intrinsic Subtype Classification To Microarray Data From a Set of Women With Mild and Severe Pre-Eclampsia. 査読有り

    Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Soichi Ogishima, Jun Nakaya, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES 22 385A-385A 2015年3月

    出版者・発行元:SAGE PUBLICATIONS INC

    ISSN:1933-7191

    eISSN:1933-7205

  40. A Map of Alzheimer’s Disease–Signaling Pathways: A Hope for Drug Target Discovery 査読有り

    S Ogishima, S Mizuno, M Kikuchi, A Miyashita, R Kuwano, H Tanaka, J Nakaya

    Clinical Pharmacology & Therapeutics 93 (5) 399-401 2013年5月

    出版者・発行元:None

    DOI: 10.1038/clpt.2013.37  

    ISSN:0009-9236

  41. AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease 査読有り

    Satoshi Mizuno, Risa Iijima, Soichi Ogishima, Masataka Kikuchi, Yukiko Matsuoka, Samik Ghosh, Tadashi Miyamoto, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka

    BMC Systems Biology 6 (52) 2012年5月

    出版者・発行元:None

    DOI: 10.1186/1752-0509-6-52  

    ISSN:1752-0509

  42. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study 査読有り

    Hypertens Res 2008年11月

︎全件表示 ︎最初の5件までを表示

MISC 20

  1. 【エコチル調査から見えてきた周産期の新たなリスク要因】産科合併症 ソーシャルキャピタル(周囲との人間関係)は,妊娠糖尿病の発症に影響するか?

    水野 聖士, 西郡 秀和, 八重樫 伸生

    臨床婦人科産科 74 (5) 481-486 2020年5月

    出版者・発行元:(株)医学書院

    ISSN:0386-9865

    eISSN:1882-1294

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    <文献概要>●ソーシャルキャピタルは,周囲の人間関係の頻度・質をとらえる概念である●子どもの健康と環境に関する全国調査(エコチル調査)の8,670人の妊婦を対象に,ソーシャルキャピタルと妊娠糖尿病の有病の間の関連解析を行った.●ソーシャルキャピタルのうち,感情・情緒面の支援関係の指標である情緒的サポートの指標と妊娠糖尿病の有病の間に有意な関連がみられ,高い情緒的サポート群は低い情緒的サポート群と比べ妊娠糖尿病のリスクが低かった.

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    水野 聖士, 和形 麻衣子, 永家 聖, 田宮 元, 栗山 進一, 八重樫 伸生, 菅原 準一, 荻島 創一

    日本妊娠高血圧学会雑誌 25 94-94 2018年11月

    出版者・発行元:日本妊娠高血圧学会

    ISSN:1880-3172

  3. 妊娠期間中の飲酒と妊娠高血圧症候群リスクとの関連

    岩間 憲之, 田中 宏典, 目時 弘仁, 西郡 秀和, 水野 聖士, 高橋 史郎, 渡邉 善, 齋藤 昌利, 櫻井 香澄, 石黒 真美, 小原 拓, 龍田 希, 西島 維知子, 杉山 隆, 藤原 幾磨, 栗山 進一, 有馬 隆博, 仲井 邦彦, 八重樫 伸生

    日本妊娠高血圧学会雑誌 25 109-109 2018年11月

    出版者・発行元:日本妊娠高血圧学会

    ISSN:1880-3172

  4. 疫学研究における妊婦の随時血圧と家庭血圧に関する検討 三世代コホート調査

    臼崎 琢磨, 石黒 真美, 小原 拓, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    日本高血圧学会総会プログラム・抄録集 41回 YIP-09 2018年9月

    出版者・発行元:(NPO)日本高血圧学会

  5. 周辺施設へのアクセシビリティと産後うつとの関連 三世代コホート調査

    永井 雅人, 水野 聖士, 石黒 真美, 宮下 真子, 山中 千鶴, 佐藤 ゆき, 松原 博子, 小原 拓, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    宮城県公衆衛生学会会誌 (50) 30-30 2018年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  6. 周辺環境へのアクセシビリティと産後6ヶ月時点の抑うつ症状との関連:三世代コホート調査

    永井雅人, 水野聖士, 小暮真奈, 石黒真美, 山中千鶴, 松原博子, 小原拓, 小原拓, 菊谷昌浩, 目時弘仁, 目時弘仁, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web) 28th 85 (WEB ONLY) 2018年2月1日

  7. 出生体重と成人期の高血圧有病との関連:東北メディカル・メガバンク計画地域住民コホート調査

    石黒真美, 小原拓, 目時弘仁, 目時弘仁, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

    日本疫学会学術総会講演集(Web) 28th 118 (WEB ONLY) 2018年2月1日

  8. 妊娠高血圧症候群(HDP)フェノタイピングのためのアルゴリズムの検討

    水野聖士, 永家聖, 飯田渓太, 笠原直子, 田宮元, 栗山進一, 八重樫伸生, 田中博, 菅原準一, 荻島創一

    日本疫学会学術総会講演集(Web) 28th 133 (WEB ONLY) 2018年2月1日

  9. 疾患概念を構造化した妊娠高血圧腎症オントロジー(PEO)の開発

    水野聖士, 西郡秀和, 和形麻衣子, 斎藤昌利, 菅原準一, 菅原準一, 田中博, 八重樫伸生, 八重樫伸生, 荻島創一

    日本妊娠高血圧学会雑誌 24 68-68 2017年9月

    出版者・発行元:(一社)日本妊娠高血圧学会

    ISSN:1880-3172

  10. 東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

    宮下 真子, 菊谷 昌浩, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 佐藤 ゆき, 石黒 真美, 小原 拓, 目時 弘仁, 栗山 進一

    東北公衆衛生学会誌 (66) 31-31 2017年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  11. 東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

    宮下 真子, 菊谷 昌浩, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 佐藤 ゆき, 石黒 真美, 小原 拓, 目時 弘仁, 栗山 進一

    東北公衆衛生学会誌 (66) 31-31 2017年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  12. 東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について 東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

    宮下 真子, 菊谷 昌浩, 田中 彰二, 山中 千鶴, 佐藤 ゆき, 水野 聖士, 石黒 真美, 小原 拓, 目時 弘仁, 成田 暁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌 (49) 14-14 2017年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  13. 三世代コホート調査における調査票結果回付における情報管理について

    永家聖, 永家聖, 下川和郎, 佐藤ゆき, 石黒真美, 水野聖士, 宮下真子, 山中千鶴, 目時弘仁, 荻島創一, 高井貴子, 栗山進一, 田中博

    日本疫学会学術総会講演集(Web) 27th 116 (WEB ONLY) 2017年1月25日

  14. 三世代コホート調査の進捗と子どもの父母の質問票

    目時弘仁, 石黒真美, 石黒真美, 小原拓, 小原拓, 佐藤ゆき, 水野聖士, 水野聖士, 宮下真子, 宮下真子, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤, 大隅典子, 大隅典子, 清元秀泰, 清元秀泰, 菅原準一, 菅原準一, 鈴木洋一, 鈴木洋一, 冨永悌二, 冨永悌二, 布施昇男, 布施昇男, 峯岸直子, 峯岸直子, 辻一郎, 辻一郎, 呉繁夫, 呉繁夫, 八重樫伸生, 八重樫伸生, 山本雅之, 山本雅之

    Journal of Epidemiology (Web) 26 (Supplement 1) 105 2016年1月21日

    ISSN:1349-9092

  15. 満期産児の臍帯血赤血球脂肪酸組成におけるdesaturase活性指標と出生体重SDスコアーについて

    長野 伸彦, 岡田 知雄, 阿部 百合子, 細野 茂春, 高橋 滋, 斉藤 恵美子, 岩田 富士彦, 原 光彦, 高橋 昌里, 川端 輝江, 仲井 邦彦, 水野 聖士, 齋藤 彰治, 有馬 隆博, 八重樫 伸生

    The Lipid 26 (2) 209-209 2015年4月

    出版者・発行元:(株)メディカルレビュー社

    ISSN:0915-6607

  16. 妊娠女性の末梢血赤血球ω3系不飽和脂肪酸の決定因子 エコチル調査の追加調査から

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    日本衛生学雑誌 70 (Suppl.) S220-S220 2015年3月

    出版者・発行元:(一社)日本衛生学会

    ISSN:0021-5082

    eISSN:1882-6482

  17. 胎盤組織における長鎖不飽和脂肪酸生合成に関わる中間代謝物の解析 出生コホート調査(エコチル調査の追加調査)での検討

    山崎 潔大, 木村 ふみ子, 仲川 清隆, 川端 輝江, 仲井 邦彦, 有馬 隆博, 水野 聖士, 八重樫 伸生, 宮澤 陽夫

    脂質栄養学 23 (2) 152-152 2014年8月

    出版者・発行元:日本脂質栄養学会

    ISSN:1343-4594

  18. 魚介類摂取のリスクとベネフィット ω3不飽和脂肪酸と出生児の各種指標との関連

    仲井 邦彦, 齋藤 彰治, 龍田 希, 下田 和美, 川端 輝江, 水野 聖士, 木村 ふみ子, 宮澤 陽夫, 有馬 隆博, 八重樫 伸生

    日本衛生学雑誌 69 (Suppl.) S247-S247 2014年5月

    出版者・発行元:(一社)日本衛生学会

    ISSN:0021-5082

    eISSN:1882-6482

  19. 母体血および臍帯血赤血球中脂肪酸組成と非妊娠時BMIとの関連

    下田 和美, 川端 輝江, 香川 靖雄, 木村 ふみ子, 宮澤 陽夫, 仲井 邦彦, 有馬 隆博, 水野 聖士, 八重樫 伸生

    日本栄養・食糧学会大会講演要旨集 68回 272-272 2014年4月

    出版者・発行元:(公社)日本栄養・食糧学会

  20. エコチル調査・宮城ユニットセンターにおける妊婦の医薬品使用状況の評価-宮城ユニットセンター薬剤詳細調査より-

    西郡 秀和, 小原 拓, 目時 弘仁, 石黒 真美, 水野 聖士, 櫻井 香澄, 岩間 憲之, 村井 ユリ子, 杉山 隆, 菅原 準一, 眞野 成康, 栗山 進一, 八重樫 伸生

    DOHaD研究 3 (1) 49-49 2014年

    出版者・発行元:日本DOHaD研究会

    ISSN:2187-2597

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    第3回日本DOHaD研究会学術集会 抄録集 【ポスター発表】

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 3

  1. 多因子疾患の環境曝露の発症機序への影響の深層学習によるシステム的解明

    荻島 創一, 川島 秀一, 宮下 哲典, 片山 俊明, 鎌田 真由美, 小島 諒介, 水野 聖士

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research

    研究種目:Grant-in-Aid for Scientific Research (B)

    研究機関:Tohoku University

    2021年4月1日 ~ 2024年3月31日

  2. 多因子疾患の立体的な層別化に基づく臨床的多様性の詳細な理解の手法の開発

    水野 聖士

    2020年4月1日 ~ 2023年3月31日

    詳細を見る 詳細を閉じる

    本年度は、東北メディカル・メガバンク計画三世代コホート調査参加者のうち妊娠高血圧症候群(HDP)患者約二千名を対象に、前年度に同定した有害アウトカムであるLight-for-date(LFD)および降圧剤への治療抵抗性の有無を正解ラベルとした機械学習モデルで取得した有害アウトカムに関連する特徴を使用し、以下の研究を実施した。 1. コミュニティ検出, 2. 検出したコミュニティの評価, 3. 検出したコミュニティで特徴的なクラスタに関連する特徴の同定 1. は、有害アウトカムに関連する特徴を入力とし、K近傍法による近傍の探索とjaccard coefficientでの類似度に基づく対象者のネットワークの構築とlouvain法とleiden法によるコミュニティ検出を実施した。 2. は、検出したコミュニティのうち、有害アウトカムに関連するものを対象に、 クラスタごとに、早産リスク、低出生体重リスク、有害アウトカムのリスク、妊娠期間をターゲットとした生存時間解析のlogrank p-valueおよびhazard ratio、割合の多い病型を評価し、HDPの臨床的多様性に対応するクラスタを取得した。3. は、2.で取得したクラスタを目的変数とした、1.で使用したすべての有害アウトカムに関連する特徴を対象に単変量解析を実施し、HDPの臨床的多様性に対応するクラスタに関連する特徴を取得した。 来年度は、今年度に実施できなかった、HDPの臨床的多様性に対応するクラスタに関連する特徴の評価と、遺伝情報と曝露情報による層別化の組み合わせで定義されるサブクラスを目的変数とした2因子間の相互作用解析および、遺伝情報と曝露情報の相互情報量を使用し構築したネットワーク上での、相互作用のある因子の背景構造の同定を行う。

  3. 妊娠高血圧症候群の高精度な予測と新規知識獲得のための人工知能の開発

    水野 聖士

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    研究種目:Grant-in-Aid for Young Scientists (B)

    研究機関:Tohoku University

    2016年4月1日 ~ 2019年3月31日

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    本研究では、生理学検査や尿検査、既往歴などの多くの情報源を統合的に解析しHDPの病態分類を行う高精度なフェノタイピングアルゴリズムの開発と、得られた病態分類の結果を正解とし、機械学習モデルの検討を行い、大規模出生コホート調査でのHDPの早期診断支援のための機械学習モデル構築のためのワークフローを検討した。その結果、大規模出生コホート調査でのHDPの早期診断支援のための機械学習の可能性が示唆された。