-
Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-3.
国際誌
査読有り
Tomoki Kita, Kyoko Chiba, Jiye Wang, Atsushi Nakagawa, Shinsuke Niwa
eLife 12 2024年1月11日
出版者・発行元:eLife Sciences Publications, Ltd
DOI:
10.7554/eLife.89040
-
Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis
招待有り
査読有り
Kyoko Chiba, Shinsuke Niwa
Current Opinion in Cell Biology 86 102301-102301 2023年12月
出版者・発行元:Elsevier BV
DOI:
10.1016/j.ceb.2023.102301
ISSN:0955-0674
-
Modeling the motion of disease-associated KIF1A heterodimers.
国際誌
査読有り
Tomoki Kita, Kazuo Sasaki, Shinsuke Niwa
Biophysical journal 122 (22) 4348-4359 2023年11月21日
DOI:
10.1016/j.bpj.2023.10.014
-
Generation of recombinant and chickenized scFv versions of an anti-kinesin monoclonal antibody H2.
国際誌
査読有り
Shinsuke Niwa, Kyoko Chiba
Cytoskeleton (Hoboken, N.J.) 2023年4月10日
DOI:
10.1002/cm.21756
-
Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans.
国際誌
査読有り
Maki Higashida, Shinsuke Niwa
Genes to cells : devoted to molecular & cellular mechanisms 2023年2月6日
DOI:
10.1111/gtc.12996
-
Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder
招待有り
査読有り
Kyoko Chiba, Tomoki Kita, Yuzu Anazawa, Shinsuke Niwa
Journal of Cell Science 136 (5) 2023年1月19日
出版者・発行元:The Company of Biologists
DOI:
10.1242/jcs.260742
ISSN:0021-9533
eISSN:1477-9137
-
Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex.
国際誌
査読有り
Shinya Taguchi, Juri Nakano, Tsuyoshi Imasaki, Tomoki Kita, Yumiko Saijo-Hamano, Naoki Sakai, Hideki Shigematsu, Hiromichi Okuma, Takahiro Shimizu, Eriko Nitta, Satoshi Kikkawa, Satoshi Mizobuchi, Shinsuke Niwa, Ryo Nitta
eLife 11 2022年9月6日
DOI:
10.7554/eLife.77877
-
De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.
国際誌
査読有り
Yuzu Anazawa, Tomoki Kita, Rei Iguchi, Kumiko Hayashi, Shinsuke Niwa
Proceedings of the National Academy of Sciences of the United States of America 119 (32) e2113795119 2022年8月9日
DOI:
10.1073/pnas.2113795119
-
CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation.
国際誌
査読有り
Tsuyoshi Imasaki, Satoshi Kikkawa, Shinsuke Niwa, Yumiko Saijo-Hamano, Hideki Shigematsu, Kazuhiro Aoyama, Kaoru Mitsuoka, Takahiro Shimizu, Mari Aoki, Ayako Sakamoto, Yuri Tomabechi, Naoki Sakai, Mikako Shirouzu, Shinya Taguchi, Yosuke Yamagishi, Tomiyoshi Setsu, Yoshiaki Sakihama, Eriko Nitta, Masatoshi Takeichi, Ryo Nitta
eLife 11 2022年6月28日
DOI:
10.7554/eLife.77365
-
An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity.
国際誌
査読有り
Juri Nakano, Kyoko Chiba, Shinsuke Niwa
Genes to cells : devoted to molecular & cellular mechanisms 27 (6) 421-435 2022年6月
DOI:
10.1111/gtc.12936
-
Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity.
国際誌
Kyoko Chiba, Kassandra M Ori-McKenney, Shinsuke Niwa, Richard J McKenney
Cell reports 39 (9) 110900-110900 2022年5月31日
DOI:
10.1016/j.celrep.2022.110900
-
Analyzing the Impact of Gene Mutations on Axonal Transport in Caenorhabditis Elegans.
国際誌
Yuzu Anazawa, Shinsuke Niwa
Methods in molecular biology (Clifton, N.J.) 2431 465-479 2022年
DOI:
10.1007/978-1-0716-1990-2_25
-
Effects of dynein inhibitor on the number of motor proteins transporting synaptic cargos.
国際誌
Kumiko Hayashi, Miki G Miyamoto, Shinsuke Niwa
Biophysical journal 120 (9) 1605-1614 2021年5月4日
DOI:
10.1016/j.bpj.2021.02.018
-
A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health.
国際誌
Aileen J Lam, Lu Rao, Yuzu Anazawa, Kyoko Okada, Kyoko Chiba, Mariah Dacy, Shinsuke Niwa, Arne Gennerich, Dan W Nowakowski, Richard J McKenney
Science advances 7 (18) 2021年4月
DOI:
10.1126/sciadv.abf1002
-
Neural and behavioral control in Caenorhabditis elegans by a yellow-light-activatable caged compound.
国際誌
Hironori Takahashi, Mako Kamiya, Minoru Kawatani, Keitaro Umezawa, Yoshiaki Ukita, Shinsuke Niwa, Toshiyuki Oda, Yasuteru Urano
Proceedings of the National Academy of Sciences of the United States of America 118 (6) 2021年2月9日
DOI:
10.1073/pnas.2009634118
-
A Combinatorial MAP Code Dictates Polarized Microtubule Transport.
国際誌
査読有り
Brigette Y Monroy, Tracy C Tan, Janah May Oclaman, Jisoo S Han, Sergi Simó, Shinsuke Niwa, Dan W Nowakowski, Richard J McKenney, Kassandra M Ori-McKenney
Developmental cell 53 (1) 60-72 2020年4月6日
DOI:
10.1016/j.devcel.2020.01.029
-
Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors.
国際誌
査読有り
Kyoko Chiba, Hironori Takahashi, Min Chen, Hiroyuki Obinata, Shogo Arai, Koichi Hashimoto, Toshiyuki Oda, Richard J McKenney, Shinsuke Niwa
Proceedings of the National Academy of Sciences of the United States of America 116 (37) 18429-18434 2019年9月10日
DOI:
10.1073/pnas.1905690116
-
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
国際誌
査読有り
Poh Hui Chia, Franklin Lei Zhong, Shinsuke Niwa, Carine Bonnard, Kagistia Hana Utami, Ruizhu Zeng, Hane Lee, Ascia Eskin, Stanley F Nelson, William H Xie, Samah Al-Tawalbeh, Mohammad El-Khateeb, Mohammad Shboul, Mahmoud A Pouladi, Mohammed Al-Raqad, Bruno Reversade
eLife 7 2018年5月22日
DOI:
10.7554/eLife.32451
-
Streptothricin acetyl transferase 2 (Sat2): A dominant selection marker for Caenorhabditis elegans genome editing.
国際誌
査読有り
Hiroyuki Obinata, Asako Sugimoto, Shinsuke Niwa
PloS one 13 (5) e0197128 2018年5月
出版者・発行元:Public Library of Science
DOI:
10.1371/journal.pone.0197128
ISSN:1932-6203
-
BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8.
国際誌
査読有り
Shinsuke Niwa, Li Tao, Sharon Y Lu, Gerald M Liew, Wei Feng, Maxence V Nachury, Kang Shen
Current biology : CB 27 (17) 2569-2578 2017年9月11日
出版者・発行元:CELL PRESS
DOI:
10.1016/j.cub.2017.07.013
ISSN:0960-9822
eISSN:1879-0445
-
Structural basis for CRMP2-induced axonal microtubule formation.
国際誌
査読有り
Shinsuke Niwa, Fumio Nakamura, Yuri Tomabechi, Mari Aoki, Hideki Shigematsu, Takashi Matsumoto, Atsushi Yamagata, Shuya Fukai, Nobutaka Hirokawa, Yoshio Goshima, Mikako Shirouzu, Ryo Nitta
Scientific reports 7 (1) 10681-10681 2017年9月6日
出版者・発行元:NATURE PUBLISHING GROUP
DOI:
10.1038/s41598-017-11031-4
ISSN:2045-2322
-
Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses.
国際誌
査読有り
Shinsuke Niwa, David M Lipton, Manatsu Morikawa, Charles Zhao, Nobutaka Hirokawa, Hang Lu, Kang Shen
Cell reports 16 (8) 2129-2141 2016年8月23日
出版者・発行元:CELL PRESS
DOI:
10.1016/j.celrep.2016.07.043
ISSN:2211-1247
-
The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans.
国際誌
査読有り
Shinsuke Niwa
Scientific reports 6 31544-31544 2016年8月12日
出版者・発行元:NATURE PUBLISHING GROUP
DOI:
10.1038/srep31544
ISSN:2045-2322
-
The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.
国際誌
査読有り
Yosuke Tanaka, Shinsuke Niwa, Ming Dong, Atena Farkhondeh, Li Wang, Ruyun Zhou, Nobutaka Hirokawa
Neuron 90 (6) 1215-1229 2016年6月15日
出版者・発行元:CELL PRESS
DOI:
10.1016/j.neuron.2016.05.002
ISSN:0896-6273
eISSN:1097-4199
-
β-Tubulin mutations that cause severe neuropathies disrupt axonal transport
国際誌
査読有り
Niwa S, Takahashi H, Hirokawa N
The EMBO Journal 32 (10) 1352-64 2013年5月15日
出版者・発行元:None
DOI:
10.1038/emboj.2013.59
ISSN:0261-4189
-
A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1A receptor.
国際誌
査読有り
Ruyun Zhou, Shinsuke Niwa, Laurent Guillaud, Ying Tong, Nobutaka Hirokawa
Cell reports 3 (2) 509-19 2013年2月21日
出版者・発行元:AMER SOC CELL BIOLOGY
DOI:
10.1016/j.celrep.2013.01.014
ISSN:1059-1524
eISSN:1939-4586
-
KIF19A is a microtubule-depolymerizing kinesin for ciliary length control.
国際誌
査読有り
Shinsuke Niwa, Kazuo Nakajima, Harukata Miki, Yusuke Minato, Doudou Wang, Nobutaka Hirokawa
Developmental cell 23 (6) 1167-75 2012年12月11日
出版者・発行元:CELL PRESS
DOI:
10.1016/j.devcel.2012.10.016
ISSN:1534-5807
-
Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches
国際誌
査読有り
Noda Y, Niwa S, Homma N, Fukuda H, Imajo-Ohmi S, Hirokawa N
Proceedings of the National Academy of Sciences 109 (5) 1725-30 2012年1月31日
出版者・発行元:None
DOI:
10.1073/pnas.1107808109
ISSN:0027-8424
-
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
国際誌
査読有り
Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka
Neuron 68 (4) 610-38 2010年11月18日
出版者・発行元:CELL PRESS
DOI:
10.1016/j.neuron.2010.09.039
ISSN:0896-6273
-
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
国際誌
査読有り
Ruyun Zhou, Shinsuke Niwa, Noriko Homma, Yosuke Takei, Nobutaka Hirokawa
Cell 139 (4) 802-13 2009年11月13日
出版者・発行元:CELL PRESS
DOI:
10.1016/j.cell.2009.10.023
ISSN:0092-8674
-
Kinesin superfamily motor proteins and intracellular transport.
国際誌
査読有り
Nobutaka Hirokawa, Yasuko Noda, Yosuke Tanaka, Shinsuke Niwa
Nature reviews. Molecular cell biology 10 (10) 682-96 2009年10月
出版者・発行元:NATURE PUBLISHING GROUP
DOI:
10.1038/nrm2774
ISSN:1471-0072
-
KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.
国際誌
査読有り
Shinsuke Niwa, Yosuke Tanaka, Nobutaka Hirokawa
Nature cell biology 10 (11) 1269-79 2008年11月
出版者・発行元:NATURE PUBLISHING GROUP
DOI:
10.1038/ncb1785
ISSN:1465-7392
-
The chromokinesin Kid forms a homodimer and moves processively along microtubules
Shinsuke Niwa, Natsuki Furusaki, Tomoki Kita, Kyoko Chiba
2024年3月13日
DOI:
10.1101/2024.03.13.584902
-
SLC-25A46 Regulates Mitochondrial Fusion through FZO-1/Mitofusin and is Essential for Maintaining Neuronal Morphology
Hiroyuki Obinata, Hironori Takahashi, Satoshi Shimo, Toshiyuki Oda, Asako Sugimoto, Shinsuke Niwa
2024年2月12日
DOI:
10.1101/2024.02.11.579862
-
Extreme-value analysis of intracellular cargo transport by motor proteins
Takuma Naoi, Yuki Kagawa, Kimiko Nagino, Shinsuke Niwa, Kumiko Hayashi
Communications Physics 7 (1) 2024年1月
DOI:
10.1038/s42005-024-01538-4
eISSN:2399-3650
-
The FHA domain is essential for the autoinhibition of KIF1A/UNC-104
Shinsuke Niwa, Taisei Watanabe, Kyoko Chiba
biroxiv 2023年12月24日
DOI:
10.1101/2023.12.24.573241
-
Characterizing Human KIF1Bß Motor Activity by Single-Molecule Motility Assays andCaenorhabtidis elegansGenetics
Rei Iguchi, Tomoki Kita, Taisei Watanabe, Kyoko Chiba, Shinsuke Niwa
biroxiv 2023年11月13日
DOI:
10.1101/2023.11.12.566784
-
Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity.
国際誌
Kyoko Chiba, Kassandra M Ori-McKenney, Shinsuke Niwa, Richard J McKenney
Cell reports 39 (13) 111016-111016 2022年6月28日
DOI:
10.1016/j.celrep.2022.111016
-
Japan-US symposium on cytoskeletal motor proteins and their associated proteins.
Kumiko Hayashi, Shinsuke Niwa
Biophysics and physicobiology 18 241-243 2021年
DOI:
10.2142/biophysico.bppb-v18.026
-
Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis.
国際誌
査読有り
Zhenhua Shao, Shinsuke Niwa, Atsushi Higashitani, Yasukazu Daigaku
DNA repair 82 102688-102688 2019年10月
DOI:
10.1016/j.dnarep.2019.102688
-
Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia.
国際誌
招待有り
査読有り
Gabrych DR, Lau VZ, Niwa S, Silverman MA
Frontiers in Neuroscience 13 419-419 2019年9月
DOI:
10.3389/fncel.2019.00419
-
Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging.
国際誌
査読有り
Shota Yanagi, Tomoya Sugai, Takuma Noguchi, Masato Kawakami, Makoto Sasaki, Shinsuke Niwa, Asako Sugimoto, Haruhiko Fuwa
Organic & biomolecular chemistry 17 (28) 6771-6776 2019年7月17日
DOI:
10.1039/c9ob01276a
-
KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth.
国際誌
査読有り
Xu F, Takahashi H, Tanaka Y, Ichinose S, Niwa S, Wicklund MP, Hirokawa N
The Journal of cell biology 217 (10) 3480-3496 2018年10月1日
DOI:
10.1083/jcb.201801085
ISSN:0021-9525
-
Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8.
国際誌
査読有り
Kumiko Hayashi, Shin Hasegawa, Takashi Sagawa, Sohei Tasaki, Shinsuke Niwa
Physical chemistry chemical physics : PCCP 20 (5) 3403-3410 2018年1月31日
出版者・発行元:Royal Society of Chemistry
DOI:
10.1039/c7cp05890j
ISSN:1463-9076
-
Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons.
国際誌
査読有り
Shinsuke Niwa
Journal of visualized experiments : JoVE (128) 2017年10月18日
出版者・発行元:JOURNAL OF VISUALIZED EXPERIMENTS
DOI:
10.3791/56690
ISSN:1940-087X
-
Characterizing KIF16B in neurons reveals a novel intramolecular "stalk inhibition" mechanism that regulates its capacity to potentiate the selective somatodendritic localization of early endosomes.
国際誌
査読有り
Atena Farkhondeh, Shinsuke Niwa, Yosuke Takei, Nobutaka Hirokawa
The Journal of neuroscience : the official journal of the Society for Neuroscience 35 (12) 5067-86 2015年3月25日
出版者・発行元:SOC NEUROSCIENCE
DOI:
10.1523/JNEUROSCI.4240-14.2015
ISSN:0270-6474
-
Kinesin superfamily proteins and the regulation of microtubule dynamics in morphogenesis.
Shinsuke Niwa
Anatomical science international 90 (1) 1-6 2015年1月
DOI:
10.1007/s12565-014-0259-5
-
[The role of kinesin superfamily proteins in morphogenesis].
Niwa S
Kaibogaku zasshi. Journal of anatomy 2014年9月
-
Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport.
国際誌
査読有り
Takao Nakata, Shinsuke Niwa, Yasushi Okada, Franck Perez, Nobutaka Hirokawa
The Journal of cell biology 194 (2) 245-55 2011年7月25日
DOI:
10.1083/jcb.201104034
ISSN:1540-8140