東北メディカル・メガバンク機構

研究キーワード

生命情報システム科学 ,数理生物物理非線形科学反応拡散系 ,Reaction-diffusion computing ,Nonlinear Science ,Mathematical Biophysics

研究分野

ライフサイエンス / 生物物理学 /
自然科学一般 / 生物物理、化学物理、ソフトマターの物理 /
自然科学一般 / 数理物理、物性基礎 /
ライフサイエンス / ゲノム生物学 /

論文

Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan

Nobuo Fuse Miyuki Sakurai Ikuko N. Motoike Kaname Kojima Takako Takai-Igarashi Naoki Nakaya Naho Tsuchiya Tomohiro Nakamura Mami Ishikuro Taku Obara Akiko Miyazawa Kei Homma Keisuke Ido Makiko Taira Tomoko Kobayashi Ritsuko Shimizu Akira Uruno Eiichi N. Kodama Kichiya Suzuki Yohei Hamanaka Hiroaki Tomita Junichi Sugawara Yoichi Suzuki Fuji Nagami Soichi Ogishima Fumiki Katsuoka Naoko Minegishi Atsushi Hozawa Shinichi Kuriyama Nobuo Yaegashi Shigeo Kure Kengo Kinoshita Masayuki Yamamoto

Ophthalmology Science 2(1) 100113-100113 2022年3月

dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Soichi Ogishima Satoshi Nagaie Satoshi Mizuno Ryosuke Ishiwata Keita Iida Kazuro Shimokawa Takako Takai-Igarashi Naoki Nakamura Sachiko Nagase Tomohiro Nakamura Naho Tsuchiya Naoki Nakaya Keiko Murakami Fumihiko Ueno Tomomi Onuma Mami Ishikuro Taku Obara Shunji Mugikura Hiroaki Tomita Akira Uruno Tomoko Kobayashi Akito Tsuboi Shu Tadaka Fumiki Katsuoka Akira Narita Mika Sakurai Satoshi Makino Gen Tamiya Yuichi Aoki Ritsuko Shimizu Ikuko N. Motoike Seizo Koshiba Naoko Minegishi Kazuki Kumada Takahiro Nobukuni Kichiya Suzuki Inaho Danjoh Fuji Nagami Kozo Tanno Hideki Ohmomo Koichi Asahi Atsushi Shimizu Atsushi Hozawa Shinichi Kuriyama Nobuo Fuse Teiji Tominaga Shigeo Kure Nobuo Yaegashi Kengo Kinoshita Makoto Sasaki Hiroshi Tanaka Masayuki Yamamoto

HUMAN GENOME VARIATION 8(1) 2021年12月

To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an i...

代謝プロファイルに影響を与える遺伝要因の網羅的解析

小柴生造元池育子三枝大輔井上仁菱沼英史青木裕一田高周城田松之木下賢吾山本雅之

日本生化学会大会プログラム・講演要旨集 94回 [P-837] 2021年11月

Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator

Mitsuhiro Yamada Ikuko N. Motoike Kaname Kojima Nobuo Fuse Atsushi Hozawa Shinichi Kuriyama Fumiki Katsuoka Shu Tadaka Matsuyuki Shirota Miyuki Sakurai Tomohiro Nakamura Yohei Hamanaka Kichiya Suzuki Junichi Sugawara Soichi Ogishima Akira Uruno Eiichi N. Kodama Naoya Fujino Tadahisa Numakura Tomohiro Ichikawa Ayumi Mitsune Takashi Ohe Kengo Kinoshita Masakazu Ichinose Hisatoshi Sugiura Masayuki Yamamoto

COMMUNICATIONS BIOLOGY 4(1) 2021年11月

Lung function reflects the ability of the respiratory system and is utilized for the assessment of respiratory diseases. Because type 2 airway inflammation influences lung function, genome wide association studies (GWAS) for lung function would be...

Subjective sleep quality, quantitative sleep features, and their associations dependent on demographic characteristics, habitual sleep–wake patterns, and distinction of weekdays/weekends

Siwalee Choilek Akihiro Karashima Ikuko Motoike Norihiro Katayama Kengo Kinoshita Mitsuyuki Nakao

Sleep and Biological Rhythms 19(4) 369-381 2021年10月

Generally applicable qualifications of sleep and principles for achieving better sleep are difficult to design, because sleep quality can depend on individual demographic characteristics and lifestyles. In this study, the static and dynamic featur...

MISC

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代謝プロファイルに影響を与える遺伝要因の網羅的解析

小柴生造小柴生造小柴生造元池育子元池育子三枝大輔三枝大輔井上仁井上仁井上仁菱沼英史青木裕一青木裕一田高周田高周城田松之城田松之城田松之木下賢吾木下賢吾木下賢吾山本雅之山本雅之山本雅之

日本生化学会大会(Web) 94th 2021年

大規模コホート研究におけるGC-MS/MSによるヒト血漿メタボローム解析

三枝大輔三枝大輔松川直美松川直美田高周田高周元池育子元池育子小柴生造小柴生造

日本プロテオーム学会誌(Web) 4(1) 2019年

ゲノミクスを基盤とした生活習慣病解析最前線ゲノム情報と連携した日本人多層オミックス参照パネルの意義

小柴生造元池育子三枝大輔井上仁城田松之青木裕一田高周斎藤智木下賢吾山本雅之

糖尿病 61(Suppl.1) S-48 2018年4月

Estimating frequency of pathogenic variants in a Japanese population by using the whole-genome reference panel of ToMMo

Yumi Yamaguchi-Kabata Jun Yasuda Osamu Tanabe Yoichi Suzuki Hiroshi Kawame Nobuo Fuse Masao Nagasaki Yosuke Kawai Kaname Kojima Fumiki Katsuoka Sakae Saito Inaho Danjoh Ikuko N. Motoike Riu Yamashita Seizo Koshiba Daisuke Saigusa Gen Tamiya Shigeo Kure Nobuo Yaegashi Yoshio Kawaguchi Fuji Nagami Shinichi Kuriyama Junichi Sugawara Naoko Minegishi Atsushi Hozawa Soichi Ogishima Hideyasu Kiyomoto Takako Takai-Igarashi Kengo Kinoshita Masayuki Yamamoto

HUMAN GENOMICS 12 2018年3月

他分野の基礎研究から学ぶ最先端研究メタボローム解析を応用した個別化医療

三枝大輔佐藤孝太齋藤律水元池育子中澤徹山本雅之

日本眼科学会雑誌 122(臨増) 30-30 2018年3月