INTRODUCTION: Body-image disturbance is a major factor in the development of eating disorders, especially among young women. There are two main components: perceptual disturbance, characterized by a discrepancy between perceived and actual body size, and affective disturbance, characterized by a discrepancy between perceived and ideal body size. Interventions targeting body-image disturbance ask individuals to describe their own body without using negative expressions when either viewing it in a mirror or imagining it. Despite the importance of reducing body-image disturbance, its neural mechanisms remain unclear. Here we investigated the changes in neural responses before and after an intervention. We hypothesized that neural responses correlated with the degree of body-image disturbance would also be related to its reduction, i.e., a reduction in perceptual and affective disturbances would be related to changes in attentional and socio-cognitive processing, respectively. METHODS: Twenty-eight young adult women without known psychiatric disorders underwent a single 40-min intervention. Participants completed tasks before and after the intervention, in which they estimated their perceived and ideal body sizes using distorted silhouette images to measure body-image disturbance. We analyzed the behavioral and neural responses of participants during the tasks. RESULTS: The intervention did not significantly reduce body-image disturbance. Analysis of individual differences showed distinct changes in neural responses for each type of disturbance. A decrease in perceptual disturbance was associated with bodily visuospatial processing: increased activation in the left superior parietal lobule, bilateral occipital gyri, and right cuneus. Reduced affective disturbance was associated with socio-cognitive processing; decreased activation in the right temporoparietal junction, and increased functional connectivity between the left extrastriate body area and the right precuneus. DISCUSSION: We identified distinct neural mechanisms (bodily visuospatial and socio-cognitive processing) associated with the reduction in each component of body-image disturbance. Our results imply that different neural mechanisms are related to reduced perceptual disturbance and the expression thereof, whereas similar neural mechanisms are related to the reduction and expression of affective disturbance. Considering the small sample size of this study, our results should be regarded as preliminary.

The COVID-19 pandemic required people to adapt rapidly to the digital transformation of society for social survival, which highlighted the divide between those who can and cannot digitalize. Previous studies investigated factors promoting adaptation to digitalization; however, outcomes from adaptation to a digitalized society have not been sorted into a parsimonious model, even though there should be several multifaceted outcomes (e.g., usefulness, economic profit, and social outcome), each of which is promoted by different factors. If the effects of individual background factors can be revealed, including the technical-environment and survival-relevant personality in relation to each outcome, it would help in the creation of a society where more people play an active role by adapting to digitalization. This study aimed to construct such a model by identifying major outcomes gained in a digitalized society and investigating individual factors that contribute to the degree of gain of each of these outcomes. Five dimensions were identified by online surveys and factor analysis: Socialization (outcomes derived from new social connections created online), Space–time (freedom from time and space constraints), Economics (monetary outcome by using digital services), and Information (ease and amount of acquisition of information) were the positive outcomes, whereas Loneliness (feelings of not being able to keep up with digitization) was identified as a negative outcome. We determined that technical-environmental factors (e.g., familiarity with digital techniques and the amount of money that can be used for digitalization) facilitated gain in four positive outcomes. Notably, leadership and conscientiousness facilitated the Socialization gain while etiquette suppressed it. These factors’ effects would reflect the importance of a personality trait prioritizing construction and maintenance of social relationships. This study implies that material outcomes (i.e., Space–time, Economics, and Information) are promoted by technical-environmental support, whereas social outcomes may additionally require motivation and a positive attitude for purposeful social engagement.

Coronavirus disease 2019 dramatically changed people’s behavior because of the need to adhere to infection prevention and to overcome general adversity resulting from the implementation of infection prevention measures. However, coping behavior has not been fully distinguished from risk perception, and a comprehensive picture of demographic, risk-perception, and psychobehavioral factors that influence the major coping-behavior factors remain to be elucidated. In this study, we recruited 2,885 Japanese participants. Major coping-behavior and risk-perception factors were identified via exploratory factor analysis of 50 candidate items. Then, we conducted a hierarchical multiple regression analysis to investigate factors associated with each coping-behavior factor. We identified four types of coping behavior [CB1 (mask-wearing), CB2 (information-seeking), CB3 (resistance to social stagnation), and CB4 (infection-prevention)] and three risk-perception factors [RP1 (shortages of daily necessities), RP2 (medical concerns), and RP3 (socioeconomic concerns)]. CB1 was positively associated with female sex and etiquette. CB2 was positively related to RP1 and RP3. CB3 was positively related to RP1 and leadership, and negatively associated with etiquette. CB4 was positively associated with female sex, etiquette, and active well-being. This parsimonious model may help to elucidate essential social dynamics and provide a theoretical framework for coping behavior during a pandemic.

Introduction Coping with mortality threat, a psychological threat unique to humans and distinct from general emotional distress, is traditionally characterized by immediate suppression and prolonged worldview defense within the framework of the influential terror management theory (TMT). Views regarding the personality-trait concepts for this coping capacity diverge: some favor a broad definition based on general psychological attitudes (e.g., hardiness), while others prefer a narrow definition linked to interpersonal attitudes related to social coalition (e.g., attachment style and self-transcendence). Methods Using functional MRI, we presented healthy older participants with death-related words and explored correlations between the neural responses to mortality threat and the factor scores of the Power to Live questionnaire, which measures eight resilience-related psychobehavioral traits. Results We observed a significant association between the factor score and a neural response only for leadership; individuals with a high leadership score exhibited reduced neural response to mortality salience in the right inferior parietal lobule. Discussion Within the TMT framework, our findings align with the concept of the immediate suppression of death-thought accessibility associated with a secure attachment style, a trait conceptually linked to leadership. These findings highlight the unique role for the narrowly defined social-coalitional trait during the immediate stage of the coping process with mortality salience, in contrast to the broadly defined resilience-related personality traits associated with a prolonged worldview defense process. The deterioration of this coping process could constitute a distinct aspect of psychopathology, separate from dysfunction in general emotion regulation.

Despite the diversity of human behavioral and psychological responses to environmental thermal stress, the major dimensions of these responses have not been formulated. Accordingly, the relevance of these responses to a framework of coping with stress (i.e., emotion- and problem-focused) and the neural correlates are unexplored. In this study, we first developed a multidimensional inventory for such responses using social surveys and a factor analysis, and then examined the neural correlates of each dimension using a functional magnetic resonance imaging; we manipulated the ambient temperature between uncomfortably hot and cold, and the correlations between the inventory factor scores and discomfort-related neural responses were examined. We identified three factors to construct the inventory: motivational decline, proactive response, and an active behavior, which appeared to reflect inefficient emotion-focused coping, efficient problem-focused coping, and positive appreciation of extreme environmental temperatures, respectively, under environmental thermal stress. Motivational decline score was positively associated with common neural response to thermal stress in the frontal and temporoparietal regions, implicated in emotion regulation, while proactive response score negatively with the neural responses related to subjective discomfort in the medial and lateral parietal cortices, implicated in problem-solving. We thus demonstrated that two of three major dimensions of individual variation in response to and coping with environmental thermal stress conform to an influential two-dimensional framework of stress coping. The current three-dimensional model may expand the frontiers of meteorological human science in both basic and application domains.

As a countermeasure against M8–9 class Nankai Trough earthquakes, the Japan Meteorological Agency started a service to release “Nankai Trough Earthquake Extra Information (Megathrust Earthquake Alert).” This alert is released after an M8.0 or higher earthquake occurs and the possibility of a subsequent earthquake is evaluated to be higher than usual. This is an innovative attempt at disaster mitigation in Japan as it encourages residents in the predefined area to pre-evacuate for one week when tsunami risk is higher. However, the factors influencing the evacuation behavior of residents are unknown. In this study, we investigated factors contributing to residents’ pre-event evacuation intentions using the hierarchical multiple regression analysis. We focused on the extent to which the recognition of the hazards and risks of the Nankai Trough earthquake and the response to the Extra Information, which are changeable by the local governments’ public relations activities, contributed to pre-event evacuation intentions after controlling for disaster-related general attitude and sociodemographic factors. Further, we paid special attention to residents’ degree of recognition of this information by checking the accuracy of their understanding of whether they lived within the pre-event evacuation area. The results showed that the recognition factors were relevant but less so than the general attitude toward disaster and more so than the sociodemographic factors. In addition, residents’ recognition accuracy was low. Our results suggest that it is important for local governments to make adequate efforts to encourage residents to evacuate.

The Great East Japan Earthquake and Tsunami struck the northeastern coastal area of Japan on 11 March 2011, resulting in the relocation of 329,000 households and the repair of 572,000 houses. Previous studies predominantly addressed the impact of demographic factors on housing recovery. However, the types of housing recoveries and the impact of individual psycho-behavioral factors have been poorly addressed. This study examined the impact of survivors’ demographic and personality-trait factors using a discriminant analysis of five types of housing recovery among 573 survivors in the five years after the disaster. The results revealed two important axes. One axis discriminated self-procured (rebuilt, repaired, and chartered housing) houses from those that were publicly available (emergency temporary and public disaster housing) affected by three personality traits (stubbornness, problem-solving, and active well-being) and survivors’ age. The other axis represented rebuilt houses affected by household size. These results demonstrate that personality traits and not just demographic factors impact three types of self-procured housing recoveries. Further exploration of personality traits that impact housing recovery can improve post-disaster reconstruction and recovery practices.

Recent psychological and neuroimaging studies on altruism–egoism dilemmas have promoted our understanding of the processes underlying altruistic motivation; however, little attention has been paid to the egoistic counter-dynamics that prompt hesitancy to help. These counter-dynamics may involve the construction of reasons not to help based on contextual elaboration and explain individual differences in the tendency to help others in daily life. In this functional magnetic resonance imaging (fMRI) study, we explored the neural correlates of altruism–egoism dilemmas during empathy-driven helping decisions, with particular attention to the counter-dynamics related to individual helping tendency traits. We used two context-rich helping decision scenarios. In the empathy dilemma (Emp) scenario, empathy-driven motivation to help a poor person was associated with a cost, whereas in the economic-dilemma (Eco) scenario, self-beneficial motivation to help a non-poor person was associated with a cost. Our results showed activation of the right anterior prefrontal cortices, supramarginal gyrus, and posterior cingulate cortex (PCC) for the altruism–egoism dilemma (i.e., Emp > Eco). A significant negative effect of the helping tendency trait score was observed on PCC activation; interestingly, this effect was observed for both Emp and Eco dilemmas. The identified neural correlates of altruism–egoism dilemmas appear to be related to the construction of decision reasons based on contextual elaboration in naturalistic situations. In contrast to the classical view, our results suggest a two-stage model that includes an altruistic helping decision followed by counter-dynamics to determine the individual helping tendency.

Although some researchers consider automatic adaptive emotion regulation to be an automatized strategy whereas others consider it to be implicit disengagement of deliberative process, to date, its neural correlates have been poorly investigated. In addition, the valence specificity of automatic adaptive emotion regulation and levels of activation relative to the neutral condition are controversial; the former is relevant to the attribution of resilient emotion regulation to positivity bias or emotional stability, and the latter to determining whether regulation is based on emotion-specific or emotion-non-specific processes. In this functional magnetic resonance imaging (fMRI) study, we presented positive and negative emotional pictures to healthy young participants and investigated the neural correlates of automatic adaptive emotion regulation in spontaneous emotional response. A significant negative trait effect (i.e., regression coefficient) on activation was identified both for positive and negative emotional responses in various cortical regions. A cluster analysis identified three clusters among these regions based on the valence specificity of the trait effect and level of activation relative to neutral stimuli. Cluster 1 included regions in the sensorimotor cortex characterized by negative emotion-specific decreases in activation relative to neutral stimuli in adaptive individuals. Cluster 2 included several cortical regions including the bilateral dorsal executive network, anterior cingulate, and inferior frontal gyrus, which were characterized by valence-independent decreases in activation in adaptive individuals. Cluster 3 included the bilateral ventrolateral and dorsomedial prefrontal cortices, right insula, and other posterior regions, which were characterized by increased activation for negative stimuli in non-adaptive individuals. These findings support the assumption that automatic adaptive emotion regulation involves the implicit disengagement of deliberative process and suggest the relevance of different cortical networks to the potential emotion- and valence-specificity of adaptive regulation.

Sincere praise reliably conveys positive or negative feedback, while flattery always conveys positive but unreliable feedback. These two praise types have not been compared in terms of communication effectiveness and individual preferences using neuroimaging. Through functional magnetic resonance imaging, we measured brain activity when healthy young participants received sincere praise or flattery after performing a visual search task. Higher activation was observed in the right nucleus accumbens during sincere praise than during flattery, and praise reliability correlated with posterior cingulate cortex activity, implying a rewarding effect of sincere praise. In line with this, sincere praise uniquely activated several cortical areas potentially involved in concern regarding others’ evaluations. A high praise-seeking tendency was associated with lower activation of the inferior parietal sulcus during sincere praise compared to flattery after poor task performance, potentially reflecting suppression of negative feedback to maintain self-esteem. In summary, the neural dynamics of the rewarding and socio-emotional effects of praise differed.

Animacy perception—discriminating between animate and inanimate visual stimuli—is the basis for engaging in social cognition and for our survival (e.g., avoiding potential danger). Previous studies indicate that factors in a target, such as the features or motion of a target, enhance animacy perception. However, factors in a perceiver, such as the visual attention of a perceiver to a target, have received little attention from researchers. Research on judgment, decision-making, and neuroeconomics indicates the active role of visual attention in constructing decisions. This study examined the role of visual attention in the perception of animacy by manipulating the exposure time of targets. Among Studies 1a to 1c conducted in this study, participants saw two face illustrations alternately; one of the faces was shown to be longer than the other. The participants chose the face that they considered more animated and rounder. Consequently, longer exposure time toward targets facilitated animacy perception and preference rather than the perception of roundness. Furthermore, preregistered Study 2 examined the underlying mechanisms. The results suggest that mere exposure, rather than orienting behavior, might play a vital role in the perception of animacy. Thus, in the reverse relationship between visual attention and animacy perception, animate objects capture attention—attention results in the perception of animacy.

Background Studies on the survivors of the 2011 Great East Japan earthquake and tsunami have revealed eight factors, called power to live, which are closely related to resilience and effective coping after intense and prolonged stress. However, whether the eight factors, which were examined in adults, are applicable to children is unclear. The purpose of this study is to evaluate whether the eight-factor structure of power to live was present since late childhood. Method A 34-item power to live questionnaire was filled by middle- to upper-grade elementary (n = 378) and junior high school students (n = 456). Moreover, because elementary school students may lack introspective ability, their power to live was evaluated through a parental assessment (n = 358). Additionally, we examined the relationship between each power to live factor and questions regarding disaster prevention awareness among 25 elementary school students. Results The results from confirmatory factor analysis for factor structure revealed generally acceptable fit indices. The reports from elementary school students and their parents significantly positively correlated with each power to live factor. Although reliability indices for factors such as stubbornness, etiquette, self-transcendence, and active well-being were not good for elementary school students, the reliability indices for all factors, excluding stubbornness, increased in junior high school students. Moreover, we identified a correlation between problem-solving, altruism, and emotional regulation and questionnaire items regarding awareness of disaster prevention in elementary school students. Conclusion Our results suggest that although factors common to adults, such as leadership, problem-solving, altruism, and emotional regulation, were identified at the elementary school stage, some factors, such as stubbornness, are in the process of being formed. Future studies should examine the developmental changes assumed to underlie these factors and their relationship to experience and neurodevelopmental basis.

The detection of object movement that is contingent on one's own actions (i.e., movements with action contingency) influences social perception of the object; such interactive objects tend to create a good impression. However, it remains unclear whether neural representation of action contingency is associated with subsequent socio-cognitive evaluation of "contacting agents", or whether the appearance of agents (e.g., face- or non-face-like avatars) is essential for this effect. In this study, we conducted a functional magnetic resonance imaging (fMRI) task with two phases: contact (contact with face- or non-face-like avatars moving contingently or non-contingently) and recognition (rating a static image of each avatar). Deactivation of the frontoparietal self-agency network and activation of the reward network were the main effects of action contingency during the contact phase, consistent with previous findings. During the recognition phase, static avatars that had previously moved in a contingent manner deactivated the frontal component of the frontoparietal network (bilateral insula and inferior-middle frontal gyri), regardless of person-like appearance. Our results imply that frontal deactivation may underlie the effect of action contingency on subsequent social perception, independent of person-like appearance.

Abstract In this study, neural representation of adult second language (L2) speakers’ implicit grammatical knowledge was investigated. Advanced L2 speakers of Japanese living in Japan, as well as L1 Japanese speakers, performed a word-monitoring task (proposed as an implicit knowledge test) in the MRI scanner. Behavioral measures were obtained from aptitude tests for explicit (language analytic ability) and implicit (statistical learning ability) learning. Findings indicate that, although both L1 and L2 speakers recruited neural circuits associated with procedural memory during the word-monitoring task, different brain regions were activated: premotor cortex (L1 speakers) and left caudate (L2 speakers). The premotor cortex activation was weaker in L2 than L1 speakers but was positively correlated with the left caudate activation, suggesting that their grammatical knowledge, while less automatized, was still developing. Behavioral sensitivity to errors was predicted only by explicit language aptitude, which may play a key role in the automatization of grammatical knowledge.

Distracted attention is considered responsible for most car accidents, and many functional magnetic resonance imaging (fMRI) researchers have addressed its neural correlates using a car-driving simulator. Previous studies, however, have not directly addressed safe driving performance and did not place pedestrians in the simulator environment. In this fMRI study, we simulated a pedestrian-rich environment to explore the neural correlates of three types of safe driving performance: accurate lane-keeping during driving (driving accuracy), the braking response to a preceding car, and the braking response to a crossing pedestrian. Activation of the bilateral frontoparietal control network predicted high driving accuracy. On the other hand, activation of the left posterior and right anterior superior temporal sulci preceding a sudden pedestrian crossing predicted a slow braking response. The results suggest the involvement of different cognitive processes in different components of driving safety: the facilitatory effect of maintained attention on driving accuracy and the distracting effect of social-cognitive processes on the braking response to pedestrians.

Body-image disturbance comprises two components. The first is perceptual in nature, and is measured by a discrepancy between one's actual body and perceived self-image ("perceived-actual discrepancy"). The other component is affective, and is measured by a discrepancy between one's perceived self-image and ideal body image ("perceived-ideal discrepancy"). The present study evaluated the relationships between body-image disturbance and characteristics of eating disorders such as symptoms and related personality traits. In a psychophysiological experiment, female university students (mean ± SD age = 21.0 ± 1.38 years) were presented with silhouette images of their own bodies that were distorted in terms of width. The participants were asked whether each silhouette image was more overweight than their actual or ideal body images. Eating-disorder characteristics were assessed using six factors from the Japanese version of the Eating Disorder Inventory 2 (EDI2). We found that perceived-actual discrepancies correlated with negative self-evaluation (i.e., factor 3 of the EDI2), whereas perceived-ideal discrepancies correlated with dissatisfaction with one's own body (i.e., factor 2 of EDI2). These results imply that distinct psychological mechanisms underlie the two components of body-image disturbance.

Self-aid and mutual assistance among victims are critical for resolving difficulties in the immediate aftermath of a disaster, but individual facilitative factors for such resolution processes are poorly understood. To identify such individual factors in the background (i.e., disaster damage and demographic) and personality domains considering different types of difficulty and resolution, we analyzed survey data collected in the 3-year aftermath of the 2011 Great East Japan Earthquake and Tsunami. We first identified major types of difficulty using a cluster analysis of 18 difficulty domains and then explored individual factors that facilitated six types of resolution (self-help, request for help, help from family, help from an acquaintance, help through cooperation, and public assistance) of these difficulty types. We identified general life difficulties and medico-psychological difficulties as two broad types of difficulty; disaster damage contributed to both types, while some personality factors (e.g., neuroticism) exacerbated the latter. Disaster damage hampered self-resolution and forced a reliance on resolution through cooperation or public assistance. On the other hand, some demographic factors, such as being young and living in a three-generation household, facilitated resolution thorough the family. Several personality factors facilitated different types of resolution, primarily of general life difficulties; the problem-solving factor facilitated self-resolution, altruism, or stubbornness resolutions through requests, leadership resolution through acquaintance, and emotion-regulation resolution through public assistance. Our findings are the first to demonstrate the involvement of different individual, particularly personality, factors in survival in the complex social dynamics of this disaster stage. They may contribute to disaster risk mitigation, allowing sophisticated risk evaluation and community resilience building.

Clarification of the individual factors determining the speed and quality of life recovery after massive disasters is crucial in assessing the vulnerability and resilience of individuals and communities. The research, however, remains in its infancy in that the index of life recovery per se is yet to be established; researchers have utilized different sets of variables, and their importance seems to vary across recovery phases potentially reflecting the change in housing situation. In addition, previous research on promoting factors of life recovery has primarily focused on demographic factors and inadequately addressed the psychological and behavioral factors, which has large educational and cultural implications. In this study, to address these two issues, we analyzed the survey data of the 2011 Great East Japan Earthquake and Tsunami disaster. First, from the multiple questionnaire items relevant to the situations of life recovery, we extracted the major elements by factor analysis and investigated their relationship to subjective sense of life recovery. At this time, we compared the relationships obtained between victims who lost their housing and those who did not. Then, we examined the psycho-behavioral as well as demographic factors promoting these life-recovery elements. The factor analysis provides two recovery elements: Well-being (health and social connections) and Housing Recovery (integrity of residential environment). The main determinant of subjective sense of life recovery was the housing recovery element for victims who had lost their houses, while it was the well-being element for those who did not experience housing loss. Among the demographic factors, a robust effect of income on the housing recovery element was identified in both victim groups while the effect of age and household structures on the two elements varied between groups. We clarified that different psycho-behavioral factors promoted two life-recovery elements. Across groups, contribution of leadership to the housing recovery element and that of neuroticism (negative), emotional regulation, and active well-being to the well-being element were identified. The former finding is consistent with the importance of consensus building in housing reconstruction, and the latter may reflect the role of common psycho-behavioral capacity oriented to individuals’ well-being including social aspects. The two life-recovery elements and their promoting factors thus identified may provide a parsimonious macroscopic framework for the evaluation and promotion of life recovery from disasters, and have practical utility for an educational approach to strengthening community resilience.

Many food decisions are made rapidly and without reflective processing. The ability to determine nutritional information accurately is a precursor of food decisions and is important for a healthy diet and weight management. However, little is known about the cognitive evaluation of food attributes based on visual information in relation to assessing nutritional content. We investigated the accuracy of visual encoding of nutritional information after brief and extended time exposures to food images. The following questions were addressed: (1) how accurately do people estimate energy and macronutrients after brief exposure to food images, and (2) how does estimation accuracy change with time exposure and the type of nutritional information? Participants were first asked to rate the energy density (calories) and macronutrient content (carbohydrates/fat/protein) of different sets of food images under three time conditions (97, 500 or 1000 ms) and then asked to perform the task with no time constraints. We calculated estimation accuracy by computing the correlations between estimated and actual nutritional information for each time exposure and compared estimation accuracy with respect to the type of nutritional information and the exposure time. The estimated and actual energy densities and individual macronutrient content were significantly correlated, even after a brief exposure time (97 ms). The degree of accuracy of the estimations did not differ with additional time exposure, suggesting that <100 ms was sufficient to predict the energy and macronutrients from food images. Additionally, carbohydrate estimates were less accurate than the estimates of other nutritional variables (proteins, fat and calories), regardless of the exposure time. These results revealed rapid and accurate assessment of food attributes based on visual information and the accuracy of visual encoding of nutritional information after brief and extended time exposure to food imagery.

This study aims to examine the neural mechanisms of resolving response competition during bilingual word recognition in the context of language intermixing. During fMRI scanning, Chinese–Japanese unbalanced bilinguals were required to perform a second-language (L2) lexical decision task composed of cognates, interlingual homographs, matched control words from both Chinese (first language) and Japanese (L2), and pseudowords. Cognate word processing showed longer reaction times and greater activation in the supplementary motor area (SMA) than L2 control word processing. In light of the orthographic and semantic overlap of cognates, these results reflect the cognitive processing involved in resolving response conflicts enhanced by the language membership of non-target language during bilingual word recognition. A significant effect of L2 proficiency was also observed only in the SMA, which is associated with the task decision system. This finding supports the bottom-up process in the BIA+ model and the Multilink model. The task/decision system receives the information from the word identification system, making appropriate responses during bilingual word recognition.

<title>Abstract</title> Career choices affect not only our financial status but also our future well-being. When making these choices, individuals evaluate their willingness to obtain a job (i.e., job values), primarily driven by simulation of future pay and interest. Despite the importance of these decisions, their underlying neural mechanisms remain unclear. In this study, we examined the neural representation of pay and interest. Forty students were presented with 80 job names and asked to evaluate their job values while undergoing functional magnetic resonance imaging (fMRI). Following fMRI, participants rated the jobs in terms of pay and interest. The fMRI data revealed that the ventromedial prefrontal cortex (vmPFC) was associated with job value representation, and the ventral and dorsal regions of the posterior cingulate cortex (PCC) were associated with pay and interest representations, respectively. These findings suggest that the neural computations underlying job valuation conform to a multi-attribute decision-making framework, with overall value signals represented in the vmPFC and the attribute values (i.e., pay and interest) represented in specific regions outside the vmPFC, in the PCC. Furthermore, anatomically distinct representations of pay and interest in the PCC may reflect the differing roles of the two subregions in future simulations.

<p>Nostalgia, a sentimental longing for the past, has attracted attention in the fields of psychology and marketing in recent years. Although these studies have identified what nostalgia is, including its triggers and functions, the question of how nostalgia is induced remains unanswered. In this article, we review existing psychological models and recent neuroimaging studies that have investigated the neural correlates of nostalgia and propose a provisional framework of nostalgia induction. The multilevel memory‒reward coactivation framework expects that different types of autobiographical memory (AM), such as episodic AM and semantic AM, activate the associated mesolimbic reward system. This framework also assumes a working self, a complex set of active goals and associated self-images, which enables us to explain individual differences in nostalgia experience by influencing what is remembered and how the retrieved information is evaluated. This framework is advantageous in that it can integrate existing psychological models into one model and can explain individual differences in nostalgia that are important for the use of nostalgia, especially in clinical situations.</p>

<title>Abstract</title> Facing one’s own death and managing the fear of death are important existential issues, particularly in older populations. Although recent functional magnetic resonance imaging (fMRI) studies have investigated brain responses to death-related stimuli, none has examined whether this brain activation was specific to one’s own death or how it was related to dispositional fear of death. In this study, during fMRI, 34 elderly participants (aged, 60–72 years) were presented with either death-related or death-unrelated negative words and asked to evaluate the relevance of these words to the “self” or the “other.” The results showed that only the left supplementary motor area (SMA) was selectively activated during self-relevant judgments of death-related words. Regression analyses of the effect of fear of death on brain activation during death-related thoughts identified a significant negative linear correlation in the right supramarginal gyrus (SMG) and an inverted-U-shaped correlation in the posterior cingulate cortex (PCC) only during self-relevant judgments. Our results suggest potential involvement of the SMA in the existential aspect of thoughts of death. The distinct fear-of-death-dependent responses in the SMG and PCC may reflect fear-associated distancing of the physical self and the processing of death-related thoughts as a self-relevant future agenda, respectively.

Humans learn languages in real-life situations by integrating multiple signals, including linguistic forms, their meanings, and the actions and intentions of speakers. However, little is known about the neural bases underlying the social learning of a second language (L2) in adults. In this study, 36 adults were asked to learn two sets of L2 spoken words through translation versus simulated social interactive videos (social learning). Brain activation during word learning was measured using fMRI. Greater activation was observed in the bilateral superior temporal sulcus, posterior middle temporal gyri, and right inferior parietal lobule during social learning as compared with translation learning. Furthermore, higher activity in the right temporal parietal junction, right hippocampus, and motor areas was observed during the initial stage of social learning, with the more successful performance being at the time of overnight testing. We argue that social learning may strengthen the link from new L2 forms to rich L2 semantic representations wherein memory properties are embodied, multimodal, and richly contextualized.

<title>Abstract</title> Eating disorder tendencies are psychological characteristics that are prevalent in healthy young females and are known to be among the risk factors for eating disorders such as anorexia and bulimia nervosa. People with greater eating disorder tendencies strongly associate sweet and fatty foods with weight gain and strictly avoid consuming such foods. However, little is known about how eating disorder tendencies influence the association between taste and body shape impression. Research on crossmodal correspondences suggests that people preferentially associate sweet tastes with round shapes, and individual differences affect the degree of such associations. This study investigates how the degree of taste–shape matching is related to eating disorder tendencies with a preliminary investigation of what mediates this relationship. Two experiments were conducted: in Experiment 1, healthy participants rated the degree of association between basic taste words (sweet/sour/salty/bitter) and roundness of shape and subsequently completed questionnaires addressing eating disorder tendencies. In Experiment 2, participants answered additional questionnaires addressing obsessiveness, dichotomous thinking, and self-esteem. The results of Experiment 1 indicated a positive correlation between drive for thinness, which is one indicator of an eating disorder tendency, and the degree of matching sweetness to round shape. Experiment 2 replicated the results of Experiment 1 and revealed the mediating effect of obsessiveness. These findings suggest a relationship between individual differences in taste–shape matching and eating disorder tendency and the preliminary mediating role of obsessiveness. The present study provides new insight into the role of sweet–round matching in eating disorder tendencies and the associated psychological mechanisms.

Temperature is an important characteristic of food and drink. In addition to food-intrinsic temperature (i.e., serving temperature), consumers often experience food-extrinsic temperature (e.g., physical warmth). Emerging research on cross-modal correspondence has revealed that people reliably associate temperature with other sensory features. Building on the literature on cross-modal correspondence and sensation transference theory, the present study aimed to reveal mental representations of temperature-taste correspondence and cross-modal mental representations influencing corresponding sensory/hedonic perceptions of beverages, with a focus on manipulating food-extrinsic warmth. To reveal mental representations of temperature-taste correspondence, Experiment 1 investigated whether temperature words (warm, cool) are associated with sensory/hedonic attributes (e.g., sweet, sour, salty, bitter). The results of Experiment 1 demonstrated that warm (vs. cool) was matched more with saltiness, tastiness, healthfulness, and preference (intention to buy), whereas cool (vs. warm) was matched more with sourness and freshness. Experiment 2 assessed whether cross-modal mental representations influence corresponding sensory/hedonic perceptions of beverages. The participants wore hot and cold pads and rated sensory/hedonic attributes of Japanese tea (Experiment 2a) or black coffee (Experiment 2b) before and after tasting it. The results of Experiment 2a demonstrated that physical warmth (vs. coldness) increased healthfulness and the intention to buy Japanese tea. The results of Experiment 2b did not reveal any effects of physical warmth on sensory/hedonic ratings. These findings provide evidence of taste-temperature correspondence and provide preliminary support for the influence of food-extrinsic warmth on taste attributes related to positivity.

BACKGROUND: Empathic concern (EC) is an important interpersonal resilience factor that represents positive adaptation, such as "relating to others" (a factor of posttraumatic growth [PTG]) after disaster. However, controversy exists regarding whether the changes in EC (e.g., the intra-personal change between the acute phase and the disillusionment phase) positively or negatively affect mental health after a disaster. We hypothesized that increased EC may increase chronic fatigue due to over-adjustment (hypothesis 1). We also hypothesized that increasing the changes in "relating to others" could decrease the changes in chronic fatigue (hypothesis 2). METHODS: Forty-nine young, healthy volunteers (M/F: 36/13; age at 3 months after the disaster [3 months]: mean ± SD: 21.1 ± 1.7 years) underwent assessments of EC using the Japanese version of the Interpersonal Reactivity Index, chronic fatigue using the Japanese version of the Checklist Individual Strength (CIS-J) questionnaire, and "relating to others" using the Japanese version of the PTG inventory during the acute phase (3 months) and the disillusionment phase (1 year after the disaster). Pearson product moment correlations at 3 months and 1 year were determined for all scores related to EC. The changes (delta = degree of change from 3 months to 1 year) or scores at 1 year were entered into linear structural equation systems to test the hypotheses. RESULTS: The delta of EC positively affected the delta of the CIS-J, and the delta of relating to others negatively affected the delta of the CIS-J. Both the EC and relating to others scores were negatively associated with the CIS-J score at 1 year. These results were in accordance with hypothesis 1 and 2. CONCLUSIONS: We demonstrated the opposite effects of 2 types of ECs, i.e., stability (inherent disposition) and flexibility (degree of change), on the degree of chronic fatigue. Increasing EC with increasing chronic fatigue, but not the change in relating to others, may be a red flag for individuals during the disillusionment phase.

PMID: 31888419

Grocery stores and restaurants can control ambient temperatures using air-conditioning. Although questions about how ambient temperature affects consumers’ evaluations of foods are relevant to many food-based businesses, they remain largely unanswered, and there are contradictory hypotheses regarding the influence of ambient temperature on food preferences. Embodiment theory suggests that ambient warm temperature increases food preferences, whereas thermoregulation theory suggests that ambient warm temperature may decrease food preferences to lower the body's temperature by limiting food intake. However, neither of these explanations considers food category. Given that food varies according to whether it is usually eaten warm or cool, the thermoregulation theory leads to the hypothesis that people may try to regulate their body temperature by preferring foods that should be eaten cool and avoiding those that should be eaten warm. To resolve these contradictory hypotheses, this study investigated the effect of warm ambient temperature on preferences for different categories of food. In total, 52 participants in a room with either warm or cool ambient temperature reported preferences for four categories of food images: vegetables, fruits, sweets, and savory foods. The foods were grouped into warm foods (i.e., foods perceived as having a warm temperature: savory foods), cold foods (i.e., foods perceived as having a cool temperature: fruits), and control foods (vegetables and sweets). The results indicated that ambient warm temperatures decreased preferences for savory foods but did not affect preferences for the other foods. The decreased preference for savory foods in warm ambient temperature was based on perceived food temperature but not on tastiness or healthfulness. These findings are the first to establish the effect of food temperature on food preference in warm ambient conditions. Incorporation of food temperature into thermoregulation theory can advance understanding of the sensory influences on consumer behaviors.

Visual attention can be automatically captured. From an evolutionary perspective, automatic attention can be useful for rapidly detecting salient stimuli, such as foods. Two attributes of foods (tastiness and healthfulness) are needed for survival. Moreover, these two attributes have different characteristics possibly associated with automatic visual attention. The more basic and hedonic attributes of tastiness are processed earlier than those of healthfulness during elaborative food choices. However, it remains unknown how the two attributes (tastiness and healthfulness) automatically capture visual attention. To this end, we investigated the extent to which taste- and health-related food information influences automatic visual attention using eye-tracking. Thirty-seven participants engaged in the target-distractor paradigm where four images were presented (top/bottom for houses as the target, left/right for foods as the distractor). Participants indicated whether the presented targets (houses) were the same or not. Visual attention toward foods would be automatic because the participants did not have to attend to them. Tastiness, but not healthfulness, captured automatic visual attention. In addition, preferred foods did not capture automatic visual attention. Even after including confounding factors associated with the stimuli (e.g., brightness, familiarity, complexity), automatic visual attention captured by tastiness remained significant. These preliminary findings indicate that humans detect hedonic food information such as tastiness, but not healthfulness or preferences.

According to the affect-as-information framework, consumers base judgments on their feelings. Disgust is associated with two kinds of appraisal: one in which the consumer avoids and distances him/herself immediately from the object concerned, and another in which the consumer is disgusted due to contamination and impurities within the environment. The first instance indicates that disgust can decrease a consumer's preference for a product, regardless of its category. In contrast, the second case suggests that a product's degree of depreciation is greater in products vulnerable to contamination, such as foods. However, it remains largely unknown how incidental disgust affects product preferences in accordance with the two appraisal-related goals. The present research investigates how incidental disgust (as opposed to sadness, an equally valenced but distinct emotion of appraisal) influences consumer preferences for products with or without a risk of contamination. Twenty-four participants repeatedly judged foods or household products after seeing an emotional image (conveying disgust, sadness, or neutrality). Foods and household products are the two representative product categories in grocery stores, but only foods are associated with a risk of contamination. The results showed that incidental disgust led to negative evaluations of both types of products however, compared to sadness, incidental disgust demonstrated a stronger negative effect on preference for foods than household products. These findings elucidate that disgust and the appraisal of contamination specifically devalue foods, and broaden the application of the appraisal-information framework in consumer settings.

The self-trait evaluation (STE) task, typically a self-descriptiveness judgment on a personality trait adjective, was initially introduced into cognitive neuroscience to address the memory enhancement effect of the self-referential (SR) process. It has now become a standard paradigm in a variety of basic psychological and clinical fields relevant to the SR process. A decade of neuroimaging research using the STE task was, however, influenced by the cortical midline structure (CMS) dogma, which oversimplified the known involvement of the CMS in the SR process to an exclusive structure-function relationship. The meta-analysis included in this chapter demonstrates that activation outside the CMS also seems to be sensitive to various task, stimulus, and participant factors of the STE task as follows: the lateral prefrontal cortex is sensitive to mental disorders, the lateral social- and body-related regions are sensitive to self-relatedness, and the body-related and visual areas are sensitive to psychological adaptation and aging. Future exploration of such variant components of the SR process over the entire cortex is warranted to enrich our cognitive neuroscientific knowledge of this process, in addition to its related psychological and clinical phenomena.

Bilingual studies using alphabetic languages have shown parallel activation of two languages during word recognition. However, little is known about the brain mechanisms of language control during word comprehension with a logogram writing system. We manipulated the types of words (interlingual homographs (IH), cognates, and language-specific words) and the types of participants (Chinese (L1) Japanese (L2) bilinguals vs. Japanese monolinguals). Greater activation was found in the bilateral inferior frontal gyri, supplementary motor area, caudate nucleus and left fusiform gyrus, when the bilinguals processed IH, as compared to cognates. These areas were also commonly activated when the bilinguals processed L2 control words during an Ll lexical decision task. The areas function as the task/decision system that plays a role in cognitive control for resolving response conflict. Furthermore, the anterior cingulate cortex, left thalamus, and left middle temporal gyrus were activated during IH processing, suggesting resolution of the semantic conflict at the stimulus level (i.e., one logographic word having different meanings in the two languages). (C) 2017 Elsevier Inc. All rights reserved.

An increasing number of biometeorological and psychological studies have demonstrated the importance and complexity of the processes involved in environmental thermal perception in humans. However, extant functional imaging data on thermal perception have yet to fully reveal the neural mechanisms underlying these processes because most studies were performed using local thermal stimulation and did not dissociate thermal sensation from comfort. Thus, for the first time, the present study employed functional magnetic resonance imaging (fMRI) and manipulated ambient temperature during brain measurement to independently explore the neural correlates of thermal sensation and comfort. There were significant correlations between the sensation of a lower temperature and activation in the left dorsal posterior insula, putamen, amygdala, and bilateral retrosplenial cortices but no significant correlations were observed between brain activation and thermal comfort. The dorsal posterior insula corresponds to the phylogenetically new thermosensory cortex whereas the limbic structures (i.e., amygdala and retrosplenial cortex) and dorsal striatum may be associated with supramodal emotional representations and the behavioral motivation to obtain heat, respectively. The co-involvement of these phylogenetically new and old systems may explain the psychological processes underlying the flexible psychological and behavioral thermo-environmental adaptations that are unique to humans.

Higher-level managers are said to have a more intuitive cognitive style. To verify this hypothesis, we must consider three factors that have often been left out of account. Previous studies, related to managerial cognitive style and job level, used a unidimensional model of cognitive style, did not consider age, and have mainly been conducted in the UK. Our study replicated previous studies on a population of 1,533 Japanese fulltime workers, using a questionnaire based on a two-dimensional model of cognitive style and setting a frame by age for each job level. Our results showed that higher job levels are associated with more rational cognitive styles. There were significant main effects of the interaction of job level and job level by age in rational thinking style. There was no correlation between intuition and job level. Our findings are the first demonstration that the relationship between job level and cognitive style likely depends on culture.

Higher-level managers are said to have a more intuitive cognitive style. To verify this hypothesis, we must consider three factors that have often been left out of account. Previous studies, related to managerial cognitive style and job level, used a unidimensional model of cognitive style, did not consider age, and have mainly been conducted in the UK. Our study replicated previous studies on a population of 1,533 Japanese fulltime workers, using a questionnaire based on a two-dimensional model of cognitive style and setting a frame by age for each job level. Our results showed that higher job levels are associated with more rational cognitive styles. There were significant main effects of the interaction of job level and job level by age in rational thinking style. There was no correlation between intuition and job level. Our findings are the first demonstration that the relationship between job level and cognitive style likely depends on culture.

Children naturally acquire a language in social contexts where they interact with their caregivers. Indeed, research shows that social interaction facilitates lexical and phonological development at the early stages of child language acquisition. It is not clear, however, whether the relationship between social interaction and learning applies to adult second language acquisition of syntactic rules. Does learning second language syntactic rules through social interactions with a native speaker or without such interactions impact behavior and the brain? The current study aims to answer this question. Adult Japanese participants learned a new foreign language, Japanese sign language (JSL), either through a native deaf signer or via DVDs. Neural correlates of acquiring new linguistic knowledge were investigated using functional magnetic resonance imaging (fMRI). The participants in each group were indistinguishable in terms of their behavioral data after the instruction. The fMRI data, however, revealed significant differences in the neural activities between two groups. Significant activations in the left inferior frontal gyrus (IFG) were found for the participants who learned JSL through interactions with the native signer. In contrast, no cortical activation change in the left IFG was found for the group who experienced the same visual input for the same duration via the DVD presentation. Given that the left IFG is involved in the syntactic processing of language, spoken or signed, learning through social interactions resulted in an fMRI signature typical of native speakers: activation of the left IFG. Thus, broadly speaking, availability of communicative interaction is necessary for second language acquisition and this results in observed changes in the brain.

In our society, partner choice is often reciprocal and, therefore, compromising one's choice may be adaptive depending on one's own market price. To reveal the neural mechanisms underlying this adaptive process, functional magnetic resonance imaging (fMRI) was performed on 27 male subjects during virtual partner choice tasks involving a dance-partner choice or a part-time job choice. Following the evaluation of a rival, the subjects chose a partner either in the face of competition with a rival (reciprocal choice condition) or during no competition (nonreciprocal condition). Irrespective of the type of partner choice situation, the posterior cingulate cortex (PCC) and right temporoparietal junction (TPJ) were specifically activated during reciprocal partner choice. The PCC was also activated during the evaluation of a rival relative to the self, which indicates the involvement of this region in the processing of one's own market price. Activation in the right TPJ was related to the individual tendency to avoid choosing a higher-value candidate when the rival-value was high in the reciprocal choice condition, which indicates that this region plays a role in market-adaptive strategy. Taken together with extant anatomical knowledge, the two-component neurobiological structure underlying the adaptive mechanism of partner choice identified in this study seems to represent the hierarchical evolution of the human socio-cognitive system. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

Consumer behaviors are shaped by fundamental motives: affiliation, self-protection, status attainment, mate attraction, mate retention, and child-rearing. It has been argued that each fundamental motive is activated by cues pertaining to threats or opportunities linked with each fundamental motive, and may be based on qualitatively different cognitive and neural systems. Steroid hormones influence specific neural systems and consumer behaviors rooted in diverse fundamental motives. By taking steroid sex hormones as examples of internal cues, we suggested that at least three fundamental motives (status attainment, mate attraction, and mate retention) may be explained by common cognitive and neural mechanisms. Consumer behaviors rooted in diverse fundamental motives, including status attainment, mate attraction, and mate retention, may be commonly explained by social motivations/vigilance (amygdala) and reward processing (reward-related brain regions). Neuroscientific tools may be useful for refining the fundamental motive framework, and for understanding more fully consumer behaviors rooted in evolutionary motives.

The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.

Early functional neuroimaging research on normal aging brain has been dominated by the interest in cognitive decline. In this framework the age-related compensatory recruitment of prefrontal cortex, in terms of executive system or reduced lateralization, has been established. Further details on these compensatory mechanisms and the findings reflecting cognitive decline, however, remain the matter of intensive investigations. Studies in another framework where age-related neural alteration is considered adaptation to the environmental change are recently burgeoning and appear largely categorized into three domains. The age-related increase in activation of the sensorimotor network may reflect the alteration of the peripheral sensorimotor systems. The increased susceptibility of the network for the mental-state inference to the socioemotional significance may be explained by the age-related motivational shift due to the altered social perception. The age-related change in activation of the self-referential network may be relevant to the focused positive self-concept of elderly driven by a similar motivational shift. Across the domains, the concept of the self and internal model may provide the theoretical bases of this adaptation framework. These two frameworks complement each other to provide a comprehensive view of the normal aging brain. (C) 2016 Elsevier B.V. All rights reserved.

INTRODUCTION: Brain-imaging techniques have begun to be popular in evaluating the effectiveness of cognitive intervention training. Although gamma activities are rarely used as an index of training effects, they have several characteristics that suggest their potential suitability for this purpose. This pilot study examined whether cognitive training in elderly people affected the high-gamma activity associated with attentional processing and whether high-gamma power changes were related to changes in behavioral performance. METHODS: We analyzed (MEG) magnetoencephalography data obtained from 35 healthy elderly subjects (60-75 years old) who had participated in our previous intervention study in which the subjects were randomly assigned to one of the three types of intervention groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C was trained to solve a crossword puzzle as an active control group. High-gamma (52-100 Hz) activity during a three-stimulus visual oddball task was measured before and after training. As a result of exclusion in the MEG data analysis stage, the final sample consisted of five subjects in Group V, nine subjects in Group P, and seven subjects in Group C. RESULTS: Results showed that high-gamma activities were differently altered between groups after cognitive intervention. In particular, members of Group V, who showed significant improvements in cognitive function after training, exhibited increased high-gamma power in the left middle frontal gyrus during top-down anticipatory target processing. High-gamma power changes in this region were also associated with changes in behavioral performance. CONCLUSIONS: Our preliminary results suggest the usefulness of high-gamma activities as an index of the effectiveness of cognitive training in elderly subjects.

Plasma oxytocin (OT) and arginine vasopressin (AVP) are associated with individual differences in emotional responses and behaviors. The amygdala is considered to be an important brain region for regulating emotion-based behavior, with OT and AVP modulating activity in the amygdala during the processing of negative emotions. In particular, increased OT levels may diminish amygdala activation (anxiolytic effects) and enhanced AVP levels may augment amygdala activation (anxiogenic effects) when negative emotions are processed. A growing body of research has shown that the effects of OT and AVP are modulated by sex: the aforementioned anxiolytic effects of OT and the anxiogenic effects of AVP occur in men, but not in women. However, we have little knowledge regarding the biological mechanisms underlying OT and AVP plasma levels or their respective anxiogenic and anxiolytic effects; similarly, little is known about the causes and nature of sex differences related to these neuropeptides and their effects on emotional processing. In the current study, we focused on the neural functions associated with the biological mechanisms underlying such effects. We hypothesized that amygdala activation would correlate with trait plasma OT (anxiolytic effects) and AVP (anxiogenic effects) levels because the amygdala is thought to affect the coordinated release of these neuropeptides following affective experiences. We further hypothesized that the effects would be modulated by sex. We assessed 51 participants (male and female) using a paradigm involving negative emotion in conjunction with functional magnetic resonance imaging and measurements of plasma OT and AVP levels. We determined that increased plasma AVP levels were positively associated with amygdala activation (anxiogenic effects) in men, but not in women. These findings highlight the potential underlying neural mechanisms of plasma AVP levels in men.

This paper introduces practical efforts to reduce local disasters in the “Project on civil empowerment for ‘zest for life during a disaster”’ undertaken by the authors and the three projects that have been developed and implemented thus far: “Pocket Notebook and Handbook for Family’s Disaster Resilience (MINNANO- BOSAI TECHO),” “Pocket Notebook and Handbook for Boys and Girls Disaster Resilience (BOKUNO- WATASHI-NO-BOSAI TECHO),” and “SENDAI CAMP (BOSAI CAMP).” These activities were reported on a public forum in the third UN World Congress on Disaster Reduction, where the importance of involving all citizens in disaster reduction and prevention through projects was recognized in a comprehensive discussion.

Spontaneous imitation is assumed to underlie the acquisition of important skills by infants, including language and social interaction. In this study, functional magnetic resonance imaging (fMRI) was used to examine the neural basis of 'spontaneously' driven imitation, which has not yet been fully investigated. Healthy participants were presented with movie clips of meaningless bimanual actions and instructed to observe and imitate them during an fMRI scan. The participants were subsequently shown the movie clips again and asked to evaluate the strength of their 'urge to imitate' (Urge) for each action. We searched for cortical areas where the degree of activation positively correlated with Urge scores; significant positive correlations were observed in the right supplementary motor area (SMA) and bilateral midcingulate cortex (MCC) under the imitation condition. These areas were not explained by explicit reasons for imitation or the kinematic characteristics of the actions. Previous studies performed in monkeys and humans have implicated the SMA and MCC/caudal cingulate zone in voluntary actions. This study also confirmed the functional connectivity between Urge and imitation performance using a psychophysiological interaction analysis. Thus, our findings reveal the critical neural components that underlie spontaneous imitation and provide possible reasons why infants imitate spontaneously.

An experimental study has been performed to examine the inherent ability to manage unexpected events using micro-world simulation. Unexpected events are defined as the events occurring without prior training and description in the operation manual. The hypothesis that the subjects who can perform better in the preliminary stage of skill development tend to perform better in unexpected situations after acquiring the necessary skill has been tested on the basis of cognitive experiments. The dynamic micro-world simulation of a smart grid system (SGS), in which the subjects are instructed to maintain a grid voltage under dynamically changing conditions, has been utilized. In the preliminary experiment, the unexpected events and situations in SGS have been prepared and the level of task difficulty has been calibrated such that the task completion rate is equal to the intended rate. In the main experiment that followed the preliminary runs, 18 subjects participated in the experiments. The experimental results supported the raised hypothesis, which emphasizes the importance of an initial screening process for the human resources against the events beyond design expectation.(C) 2016 IFAC (Internantional federation of Automatic Control ) Hosting by Elsevier Ltd. All rights reserved.

Self-face recognition in the mirror is considered to involve multiple processes that integrate 2 perceptual cues: temporal contingency of the visual feedback on one's action (contingency cue) and matching with self-face representation in long-term memory (figurative cue). The aim of this study was to examine the neural bases of these processes by manipulating 2 perceptual cues using a "virtual mirror" system. This system allowed online dynamic presentations of real-time and delayed self- or other facial actions. Perception-level processes were identified as responses to only a single perceptual cue. The effect of the contingency cue was identified in the cuneus. The regions sensitive to the figurative cue were subdivided by the response to a static self-face, which was identified in the right temporal, parietal, and frontal regions, but not in the bilateral occipitoparietal regions. Semantic- or integration-level processes, including amodal self-representation and belief validation, which allow modality-independent self-recognition and the resolution of potential conflicts between perceptual cues, respectively, were identified in distinct regions in the right frontal and insular cortices. The results are supportive of the multicomponent notion of self-recognition and suggest a critical role for contingency detection in the co-emergence of self-recognition and empathy in infants.

People perceive, judge, and behave differently in disasters and in a wide range of other difficult situations depending on their personal characteristics. The power to live, as captured by characteristics that are advantageous for survival in such situations, has thus far been modeled in arbitrary ways. Conceptualizing such characteristics in more objective ways may be helpful for systematic preparations for future disasters and life difficulties. Here, we attempted to identify the major factors of the power to live by summarizing the opinions of survivors of the 2011 Great East Japan Earthquake disaster. We conducted personal interviews with 78 survivors about their survival experiences and elicited their opinions about the power to live as relevant to those experiences. We then incorporated these opinions into a questionnaire that was completed by 1400 survivors. Factor analysis identified eight factors related to the power to live: leadership, problem solving, altruism, stubbornness, etiquette, emotional regulation, self-transcendence, and active well-being. All factors had sufficient internal construct validity, and six of them showed significant associations with one or more measures of survival success in the disaster, including immediate tsunami evacuation, problem solving in refugee situations, recovery during reconstruction, physical health, and mental health. Overall, the personal characteristics described by the eight factors largely overlap with those described in previous arbitrary models. Further research should investigate the domains, phases, and contexts in which each factor contributes to survival, address whether the factors are rooted in nature or in nurture, and explore their psychological or physiological bases.

Interoceptive (feelings from inside organs) attention/awareness (IAA) is a body-related aspect of cognition that pursues homeostasis by detecting afferent signals, and there are practices aimed at focusing one's attention and awareness towards such feelings inside one's own body. There is a claim that these practices improve health which is one reason that neural correlates of such practices and IAA in general have been investigated in previous imaging studies. In several of these studies which used subjects with no or limited experience in IAA practices there was a report of supramarginal (SM) activity during IAA tasks, but the role of SM in IAA remain unclear. We first investigated if we could find similar results in novices, and if this activity is sensitive to the designated body part in the IAA task. We further investigated if these regions would be similarly recruited in subjects with extensive experience of IAA tasks while comparing results with a group of age and gender matched novices. Results in the novices replicated that of previous studies, and we showed this is the same for IAA tasks regarding two different parts of the body. Group comparison results showed opposite profiles of SM activation for the two groups; novices showed activation and the experts showed deactivation of the SM. The results suggest that novices recruit SM during IAA possibly due to lack of experience in those tasks but this could be alleviated for performing IAA as illustrated by activation profile in experts.

Communicative speech is a type of language use that involves goal-directed action targeted at another person based on social interactive knowledge. Previous studies regarding one's first language (L1) have treated the theory of mind system, which is associated with understanding others, and the sensorimotor system, which is associated with action simulation, as important contributors to communication. However, little is known about the neural basis of communication in a second language (L2), which is limited in terms of its use as a communication tool. In this fMRI study, we manipulated the type of speech (i.e., communication vs. description) and the type of language (L1 vs. L2) to identify the specific brain areas involved in L2 communication. We also attempted to examine how the cortical mechanisms underlying L2 speech production are influenced by oral proficiency and anxiety regarding L2. Thirty native Japanese speakers who had learned English as an 12, performed communicative and descriptive speech-production tasks in both L1 and L2 while undergoing fMRI scanning. We found that the only the L2 communication task recruited the left posterior supramarginal gyrus (pSMG), which may be associated with the action simulation or prediction involved in generating goal-directed actions. Furthermore, the neural mechanisms underlying L2 communication, but not L2 description, were sensitive to both oral proficiency and anxiety levels; (a) activation in the left middle temporal gyrus (MTG) increased as oral proficiency levels increased, and (b) activation in the orbitofrontal cortex (OFC), including the left insula, decreased as L2 anxiety levels increased. These results reflect the successful retrieval of lexical information in a pragmatic context and an inability to monitor social behaviors due to anxiety. Taken together, the present results suggest that L2 communication relies on social skills and is mediated by anxiety and oral proficiency. (C) 2014 Published by Elsevier Ltd.

We investigated the neural mechanisms underlying the ability to cope in atypical or novel situations using tools. We hypothesized that two cognitive components support this ability: adaptive coordination (for adapting to situational demands) and cognitive inhibition (for inhibiting the incongruent actions afforded by tools). We had subjects choose novel tools for a given task or choose among familiar tools in an atypical situation, during which we examined cortical activation in their brains using functional magnetic resonance imaging. Neural activation during adaptive coordination was observed in the left lateral orbitofrontal cortex, inferior frontal gyrus and sulcus, middle and medial frontal gyrus, intraparietal sulcus, precentral sulcus, inferior temporal gyrus, supramarginal gyrus, the bilateral insula, anterior cingulate cortex, and the right callosal sulcus. Activation indicating cognitive inhibition was observed in the right middle and inferior frontal gyrus. These findings demonstrate that the left parietal region shapes basic action, whereas the right frontal region inhibits stereotypical action. The left frontal regions are thought to be linked to the processing of ambiguous actions and play key roles in coordinating actions, whereas other regions are involved in processing situational contexts. Our results may be important for understanding the neural systems underlying adaptability to daily social situations. (C) 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

The recognition of self-face is a unique and complex phenomenon in many aspects, including its associated perceptual integration process, its emergence during development, and its socio-motivational effect. This may explain the failure of classical attempts to identify the cortical areas specifically responsive to self-face and designate them as a unique system related to 'self'. Neuroimaging findings regarding self-face recognition seem to be explained comprehensively by a recent forward-model account of the three categories of self: the physical, interpersonal, and social selves. Self-face-specific activation in the sensory and motor association cortices may reflect cognitive scrutiny due to prediction error or task-induced top-down attention in the physical internal schema related to the self-face. Self-face-specific deactivation in some amodal association cortices in the dorsomedial frontal and lateral posterior cortices may reflect adaptive suppression of the default recruitment of the social-response system during face recognition. Self-face-specific activation under a social context in the ventral aspect of the medial prefrontal cortex and the posterior cingulate cortex may reflect cognitive scrutiny of the internal schema related to the social value of the self. The multi-facet nature of self-face-specific activation may hold potential as the basis for a multi-dimensional diagnostic tool for the cognitive system. (C) 2014 The Author. Published by Elsevier Ireland Ltd.

When sounds occur with temporally structured patterns, we can feel a rhythm. To memorize a rhythm, perception of its temporal patterns and organization of them into a hierarchically structured sequence are necessary. On the other hand, rhythm perception can often cause unintentional body movements. Thus, we hypothesized that rhythm information can be manifested in two different ways; temporal and motor representations. The motor representation depends on effectors, such as the finger or foot, whereas the temporal representation is effector-independent. We tested our hypothesis with a working memory paradigm to elucidate neuronal correlates of temporal or motor representation of rhythm and to reveal the neural networks associated with these representations. We measured brain activity by fMRI while participants memorized rhythms and reproduced them by tapping with the right finger, left finger, or foot, or by articulation. The right inferior frontal gyrus and the inferior parietal lobule exhibited significant effector-independent activations during encoding and retrieval of rhythm information, whereas the left inferior parietal lobule and supplementary motor area (SMA) showed effector-dependent activations during retrieval. These results suggest that temporal sequences of rhythm are probably represented in the right fronto-parietal network, whereas motor sequences of rhythm can be represented in the SMA-parietal network.

After the 2011 Great East Japan (Tohoku) earthquake and tsunami disaster, reduction and avoidance of potential losses from disasters have received much attention. We focused on disaster education which is defined simply as disaster risk reduction education. We developed new educational tool for disaster education. We called the new game-book the “disaster simulation game-book.” This study was designed to investigate the beneficial effects of experimental learning using the disaster simulation game-book on disaster education for children. Thirty four junior high school students participated in the study. They were randomly assigned into learning with the game book or learning with the cartoon film groups. They answered some questions before and after learning disaster. The results clearly demonstrated the beneficial effects of game-book learning on attitudes of disasters measured for question (If a large earthquake occurred, could you overcome difficulty from the earthquake on your own?) and question (If a large earthquake occurred, do you think that you could safely get clear away?). We discussed beneficial effects of the game-book on disaster education.

Visual object recognition is classically believed to involve two stages: a perception stage in which perceptual information is integrated, and a memory stage in which perceptual information is matched with an object's representation. The transition from the perception to the memory stage can be slowed to allow for neuroanatomical segregation using a degraded visual stimuli (DVS) task in which images are first presented at low spatial resolution and then gradually sharpened. In this functional magnetic resonance imaging study, we characterized these two stages using a DVS task based on the classic model. To separate periods that are assumed to dominate the perception, memory, and post-recognition stages, subjects responded once when they could guess the identity of the object in the image and a second time when they were certain of the identity. Activation of the right medial occipitotemporal region and the posterior part of the rostral medial frontal cortex was found to be characteristic of the perception and memory stages, respectively. Although the known role of the former region in perceptual integration was consistent with the classic model, a likely role of the latter region in monitoring for confirmation of recognition suggests the advantage of recently proposed interactive models. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license

The current study used a magnetoencephalogram to investigate the relationship between high-gamma (52-100 Hz) activity within an attention network and individual differences in behavioral performance among healthy elderly adults. We analyzed brain activity in 41 elderly subjects performing a 3-stimulus visual oddball task. In addition to the average amplitude of event-related fields in the left intraparietal sulcus (IPS), high-gamma power in the left middle frontal gyrus (MFG), the strength of high-gamma imaginary coherence between the right MFG and the left MFG, and those between the right MFG and the left thalamus predicted individual differences in reaction time. In addition, high-gamma power in the left MFG was correlated with task accuracy, whereas high-gamma power in the left thalamus and left IPS was correlated with individual processing speed. The direction of correlations indicated that higher high-gamma power or coherence in an attention network was associated with better task performance and, presumably, higher cognitive function. Thus, high-gamma activity in different regions of this attention network differentially contributed to attentional processing, and such activity could be a fundamental process associated with individual differences in cognitive aging. (C) 2014 Elsevier Inc. All rights reserved.

The present study used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of language acquisition in a realistic learning environment. Japanese native speakers were trained in a miniature version of German prior to fMRI scanning. During scanning they listened to (1) familiar sentences, (2) sentences including a novel sentence structure, and (3) sentences containing a novel word while visual context provided referential information. Learning-related decreases of brain activation over time were found in a mainly left-hemispheric network comprising classical frontal and temporal language areas as well as parietal and subcortical regions and were largely overlapping for novel words and the novel sentence structure in initial stages of learning. Differences occurred at later stages of learning during which content-specific activation patterns in prefrontal, parietal and temporal cortices emerged. The results are taken as evidence for a domain-general network supporting the initial stages of language learning which dynamically adapts as learners become proficient.

Implicit or automatic detection of social signals, which discriminate animate, intentional objects in the environment, is essential for higher social cognition and its development. Using functional magnetic resonance imaging, we identified the neural substrate of detecting simple visual social signals and examined its functional link with the mechanism of inferring another's mental state. Healthy participants were presented with the eye-gaze shift (EG) and self-propelling motion (SP) under both implicit and explicit task conditions. They also performed a social role-playing game in which mental inference (MI) was implicitly prompted during the presentation of faces (implicit MI). Implicit detection of EG and SP activated the posterior middle temporal gyrus (pMTG) bilaterally, whereas the right posterior superior temporal sulcus was activated during the explicit conditions. We revealed that the individual variation in neural response in the right pMTG during implicit eye-gaze detection explains the individual tendency to recruit the regions implicated in mental-state inference (medial prefrontal cortex, temporal pole and striatum) during the implicit MI task. Our results suggest that the implicit detection of visual social signals involves the pMTG and underlies the development of higher social cognition.

Most inhabitants of Tohoku district suffer from chronic fatigue after the 2011 Great East Japan Earthquake. Chronic fatigue following disasters may lead to serious illness, even death. Posttraumatic growth appears to counteract fatigue. We predicted that the chronic fatigue would be inversely related to the posttraumatic growth factor "relating to others," as represented by mutual helping and a strong sense of connection with humanity. Young 59 healthy volunteers, residing in Miyagi prefecture, were recruited 3 months after the disaster. We measured the subjects׳ total scores on the Japanese version of the Checklist Individual Strength questionnaire (CIS), the Trait Anxiety (T-A) subscale of the State-Trait Anxiety Inventory (STAI), the Center for Epidemiologic Studies Depression Scale (CES-D), and four subscores on the posttraumatic growth inventory (PTGI). Stepwise regression analyses were conducted with score on the CIS as the dependent variable and other scores as independent variables. Scores on the "relating to others" factor of the PTGI showed a significant negative relationship with the CIS score, whereas the scores on the T-A subscale of the STAI and the CES-D were positively related to the CIS score. Human ties and mutual help were negatively related to the degree of the chronic fatigue.

Older children are more successful at producing unfamiliar, non-native speech sounds than younger children during the initial stages of learning. To reveal the neuronal underpinning of the age-related increase in the accuracy of non-native speech production, we examined the developmental changes in activation involved in the production of novel speech sounds using functional magnetic resonance imaging. Healthy right-handed children (aged 6-18 years) were scanned while performing an overt repetition task and a perceptual task involving aurally presented non-native and native syllables. Productions of non-native speech sounds were recorded and evaluated by native speakers. The mouth regions in the bilateral primary sensorimotor areas were activated more significantly during the repetition task relative to the perceptual task. The hemodynamic response in the left inferior frontal gyrus pars opercularis (IFG pOp) specific to non-native speech sound production (defined by prior hypothesis) increased with age. Additionally, the accuracy of non-native speech sound production increased with age. These results provide the first evidence of developmental changes in the neural processes underlying the production of novel speech sounds. Our data further suggest that the recruitment of the left IFG pOp during the production of novel speech sounds was possibly enhanced due to the maturation of the neuronal circuits needed for speech motor planning. This, in turn, would lead to improvement in the ability to immediately imitate non-native speech.

Social considerations significantly influence daily purchase decisions, and the perception of social risk (i.e., the anticipated disapproval of others) is crucial in dissuading consumers from making purchases. However, the neural basis for consumers' perception of social risk remains undiscovered, and this novel study clarifies the relevant neural processes. A total of 26 volunteers were scanned while they evaluated purchase intention of products (purchase intention task) and their anticipation of others' disapproval for possessing a product (social risk task), using functional magnetic resonance imaging (fMRI). The fMRI data from the purchase intention task was used to identify the brain region associated with perception of social risk during purchase decision making by using subjective social risk ratings for a parametric modulation analysis. Furthermore, we aimed to explore if there was a difference between participants' purchase decisions and their explicit evaluations of social risk, with reference to the neural activity associated with social risk perception. For this, subjective social risk ratings were used for a parametric modulation analysis on fMRI data from the social risk task. Analysis of the purchase intention task revealed a significant positive correlation between ratings of social risk and activity in the anterior insula, an area of the brain that is known as part of the emotion-related network. Analysis of the social risk task revealed a significant positive correlation between ratings of social risk and activity in the temporal parietal junction and the medial prefrontal cortex, which are known as theory-of-mind regions. Our results suggest that the anterior insula processes consumers' social risk implicitly to prompt consumers not to buy socially unacceptable products, whereas ToM-related regions process such risk explicitly in considering the anticipated disapproval of others. These findings may prove helpful in understanding the mental processes involved in purchase decisions. (C) 2014 Elsevier Inc All rights reserved.

Event simulation (ES) is the situational inference process in which perceived event features such as objects, agents, and actions are associated in the brain to represent the whole situation. ES provides a common basis for various cognitive processes, such as perceptual prediction, situational understanding/prediction, and social cognition (such as mentalizing/trait inference). Here, functional magnetic resonance imaging was used to elucidate the neural substrates underlying important subdivisions within ES. First, the study investigated whether ES depends on different neural substrates when it is conducted explicitly and implicitly. Second, the existence of neural substrates specific to the future-prediction component of ES was assessed. Subjects were shown contextually related object pictures implying a situation and performed several picture-word-matching tasks. By varying task goals, subjects were made to infer the implied situation implicitly/explicitly or predict the future consequence of that situation. The results indicate that, whereas implicit ES activated the lateral prefrontal cortex and medial/lateral parietal cortex, explicit ES activated the medial prefrontal cortex, posterior cingulate cortex, and medial/lateral temporal cortex. Additionally, the left temporoparietal junction plays an important role in the future-prediction component of ES. These findings enrich our understanding of the neural substrates of the implicit/explicit/predictive aspects of ES-related cognitive processes.

Verbal irony conveys various emotional messages, from criticism to humor, that differ from the meaning of the actual words. To understand irony, we need conceptual knowledge of irony in addition to an understanding of context. We investigated the neural mechanism of irony comprehension, focusing on two overlooked issues: conceptual knowledge and emotional response. We studied 35 healthy subjects who underwent functional MRI. During the scan, the subject examined first-person-view stories describing verbal interactions, some of which included irony directed toward the subject. After MRI, the subject viewed the stories again and rated the degree of irony, humor, and negative emotion evoked by the statements. We identified several key findings about irony comprehension: (1) the right anterior superior temporal gyrus may be responsible for representing social conceptual knowledge of irony, (2) activation in the medial prefrontal cortex and the right anterior inferior temporal gyrus might underlie the understanding of context, (3) modulation of activity in the right amygdala, hippocampus, and parahippocampal gyrus is associated with the degree of irony perceived, and (4) modulation of activity in the right dorsolateral prefrontal cortex varies with the degree of humor perceived. Our results clarified the differential contributions of the neural loci of irony comprehension, enriching our understanding of pragmatic language communication from a social behavior point of view. Hum Brain Mapp 35:1167-1178, 2014. (c) 2013 Wiley Periodicals, Inc.

我々は、円滑な人間関係を確立・維持するために言語的配慮（ポライトネス）を行っている。ポライトネスには、他者に邪魔されたくないという欲求に配慮する方略（ネガティブポライトネス）と、他者に認められたいという欲求に配慮する方略（ポジティブポライトネス）の2方向の方略がある。本研究では、fMRIを用いて発話産出におけるポライトネスの神経基盤を検討した。実験参加者は、MRIの中で、日常場面で些細な失敗をした架空の友人に対して、 (1)ポジティブポライトネスを用いる、(2)ネガティブポライトネスを用いる条件、(3)ポライトネスを用いない、のいずれかの条件で発話の産出を行った。その結果、ネガティブポライトネス特異的な領域として左眼窩前頭皮質前部および右眼窩前頭皮質後部を、ネガティブポライトネス特異的な領域として右扁桃体を、両方のポライトネスに共通して関与する領域として右外側眼窩前頭皮質後部を同定した。

This paper reports on an exploratory study of "Zest for Living in disaster" to propose a hypothesis based on a qualitative survey and analysis on the text data of personal interviews with 78 victims of the 2011 Great East Japan Earthquake disaster. The main results are as follows: 1) Correspondence and handling cases are divided into four categories of Emergency response immediately after a disaster, First response, Recovery response and Common phases. 2) Appropriate response is classified into Personal character, Attitude and habit, Social capital, Individual capability and resources, and Disaster experiences of "Zest for Living in disaster" in the past.

Many survivors of severe disasters need psychological support, even those not suffering post-traumatic stress disorder (PTSD). The critical issue in understanding the psychological response after experiencing severe disasters is to distinguish neurological microstructural underpinnings as vulnerability factors from signs of emotional distress acquired soon after the stressful life event. We collected diffusion-tensor magnetic resonance imaging (DTI) data from a group of healthy adolescents before the Great East Japan Earthquake and re-examined the DTIs and anxiety levels of 30 non-PTSD subjects from this group 3-4 months after the earthquake using voxel-based analyses in a longitudinal DTI study before and after the earthquake. We found that the state anxiety level after the earthquake was negatively associated with fractional anisotropy (FA) in the right anterior cingulum (Cg) before the earthquake (r = -0.61, voxel level p<0.0025, cluster level p<0.05 corrected), and positively associated with increased FA changes from before to after the earthquake in the left anterior Cg (r = 0.70, voxel level p<0.0025, cluster level p<0.05 corrected) and uncinate fasciculus (Uf) (r = 0.65, voxel level p<0.0025, cluster level p<0.05 corrected). The results demonstrated that lower FA in the right anterior Cg was a vulnerability factor and increased FA in the left anterior Cg and Uf was an acquired sign of state anxiety after the earthquake. We postulate that subjects with dysfunctions in processing fear and anxiety before the disaster were likely to have higher anxiety levels requiring frequent emotional regulation after the disaster. These findings provide new evidence of psychophysiological responses at the neural network level soon after a stressful life event and might contribute to the development of effective methods to prevent PTSD.

From an evolutionary viewpoint, readiness to engage in appropriate behavior toward a recognized person seems to be inherent in the human brain. In support of this hypothesis, functional neuroimaging studies have demonstrated activation in regions relevant to relationship-appropriate behavior during the recognition of personally familiar (PF) people. Recognition of friends and colleagues activates regions involved in real-time communication, including the regions for inference about the other's mental state, autobiographical memory retrieval, and self-referential processes. Recognition of people related by romantic love, maternal love, and lost love induces activation in regions involved in motivational, reward, and affective processes, reflecting behavioral readiness for mating, caretaking, and yearning, respectively. The involvement of motor-associated cortices during recognition of a personal enemy may reflect readiness for attack or defense. Self-recognition in a body-related modality uniquely activates sensory and motor association cortices reflecting the sensorimotor origin of the bodily self-concept, with social cognitive processes being suppressed or context dependent. Issues and future directions are also discussed.

Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability factor and increased WMI in the left anterior Cg and uncinate fasciculus (Uf) after the earthquake was an acquired sign of postearthquake distress. However, the long-term effects on WMI remained unclear. Here, we examined the 1-year WMI changes in 25 subjects to clarify long-term effects on the WMI. We found differential FAs in the right anterior Cg, bilateral Uf, left superior longitudinal fasciculus (SLF), and left thalamus, suggesting that synaptic enhancement and shrinkage were long-term effects. Additionally, the correlation between psychological measures related to postearthquake distress and the degree of WMI alternation in the right anterior Cg and the left Uf led us to speculate that temporal WMI changes in some subjects with emotional distress occurred soon after the disaster. We hypothesized that dynamic WMI changes predict a better prognosis, whereas persistently lower WMI is a marker of cognitive dysfunction, implying the development of anxiety disorders.

Can ongoing fMRI BOLD signals predict fluctuations in swiftness of a person's response to sporadic cognitive demands? This is an important issue because it clarifies whether intrinsic brain dynamics, for which spatio-temporal patterns are expressed as temporally coherent networks (TCNs), have effects not only on sensory or motor processes, but also on cognitive processes. Predictivity has been affirmed, although to a limited extent. Expecting a predictive effect on executive performance for a wider range of TCNs constituting the cingulo-opercular, fronto-parietal, and default mode networks, we conducted an fMRI study using a version of the color-word Stroop task that was specifically designed to put a higher load on executive control, with the aim of making its fluctuations more detectable. We explored the relationships between the fluctuations in ongoing pre-trial activity in TCNs and the task response time (RT). The results revealed the existence of TCNs in which fluctuations in activity several seconds before the onset of the trial predicted RT fluctuations for the subsequent trial. These TCNs were distributed in the cingulo-opercular and fronto-parietal networks, as well as in perceptual and motor networks. Our results suggest that intrinsic brain dynamics in these networks constitute "cognitive readiness," which plays an active role especially in situations where information for anticipatory attention control is unavailable. Fluctuations in these networks lead to fluctuations in executive control performance.

Many disciplines/traditions that promote interoceptive (inner sensation of body parts) attention/awareness (IAA) train practitioners to both attend to and be aware of interoceptive sensory experiences in body parts. The effect of such practices has been investigated in previous imaging studies but limited to cerebral neural activity. Here, for the first time, we studied the impact of these practices on the spinal neural activity of experts and novices. We also attempted to clarify the effect of constant and deep breathing, a paradigm utilized in concentration practices to avoid mind wandering, on IAA-related spinal neural activity. Subjects performed IAA tasks with and without a deep and constant breathing pattern in two sessions. Results showed that neural activity in the spinal segment innervating the attended-to body area increased in experts (P = 0.04) when they performed IAA and that this increase was significantly larger for experts versus novices in each of the sessions (P = 0.024). The significant effects of IAA and expertise on spinal neural activity are consistent with and elaborate on previous reports showing similar effects on cerebral neural activity. As the spinal cord directly innervates body parts, the results might indicate that IAA has an instantaneous (possibly beneficial) effect on the physical body after extended training.

The neural correlates of "self" identified by neuroimaging studies differ depending on which aspects of self are addressed. Here, three categories of self are proposed based on neuroimaging findings and an evaluation of the likely underlying cognitive processes. The physical self, representing self-agency of action, body-ownership, and bodily self-recognition, is supported by the sensory and motor association cortices located primarily in the right hemisphere. The interpersonal self, representing the attention or intentions of others directed at the self, is supported by several a modal association cortices in the dorso medial frontal and lateral posterior cortices. The social self, representing the self as a collection of context dependent social-values, is supported by the ventral aspect of the medial prefrontal cortex and the posterior cingulate cortex. Despite differences in the underlying cognitive processes and neural substrates, all three categories of self are likely to share the computational characteristics of the forward model, which is underpinned by internal schema or learned associations between one's behavioral output and the consequential input. Additionally, these three categories exist with in a hierarchical layer structure based on developmental processes that updates the schema through the attribution of prediction error. In this account, most of the association cortices critically contribute to some aspect of the self through associative learning while the primary regions involved shift from the lateral to the medial cortices in a sequence from the physical to the interpersonal to the social self.

災害ストレスに起因する精神症状と脳形態変化について多数報告はあるが、災害ストレス暴露後の横断研究が主であり、災害後精神症状の脆弱性/獲得因子としての脳形態変化は未解明であった。本稿では、我々が発表した脳形態変化と震災後精神症状の因果関係を解明した最新の研究を紹介し、複数の脳画像データが示唆する生物学的背景について文献的考察を加え、今後の災害ストレスに関わる脳画像研究の方向性を探る。(著者抄録)

Background: Frustrating situations are encountered daily, and it is necessary to respond in an adaptive fashion. A psychological definition states that adaptive social behaviors are "self-performing" and "contain a solution." The present study investigated the neural correlates of adaptive social responses to frustrating situations by assessing the dimension of causal attribution. Based on attribution theory, internal causality refers to one's aptitudes that cause natural responses in real-life situations, whereas external causality refers to environmental factors, such as experimental conditions, causing such responses. To investigate the issue, we developed a novel approach that assesses causal attribution under experimental conditions. During fMRI scanning, subjects were required to engage in virtual frustrating situations and play the role of protagonists by verbalizing social responses, which were socially adaptive or non-adaptive. After fMRI scanning, the subjects reported their causal attribution index of the psychological reaction to the experimental condition. We performed a correlation analysis between the causal attribution index and brain activity. We hypothesized that the brain region whose activation would have a positive and negative correlation with the self-reported index of the causal attributions would be regarded as neural correlates of internal and external causal attribution of social responses, respectively. Results: We found a significant negative correlation between external causal attribution and neural responses in the right anterior temporal lobe for adaptive social behaviors. Conclusion: This region is involved in the integration of emotional and social information. These results suggest that, particularly in adaptive social behavior, the social demands of frustrating situations, which involve external causality, may be integrated by a neural response in the right anterior temporal lobe.

Fatigue reflects the functioning of our physiological negative feedback system, which prevents us from overworking. When fatigued, however, we often try to suppress this system in an effort to compensate for the resulting deterioration in performance. Previous studies have suggested that the effect of fatigue on neurovascular demand may be influenced by this compensatory effort. The primary goal of the present study was to isolate the effect of compensatory effort on neurovascular demand. Healthy male volunteers participated in a series of visual and auditory divided attention tasks that steadily increased fatigue levels for 2 hours. Functional magnetic resonance imaging scans were performed during the first and last quarter of the study (Pre and Post sessions, respectively). Tasks with low and high attentional load (Low and High conditions, respectively) were administrated in alternating blocks. We assumed that compensatory effort would be greater under the High-attentional-load condition compared with the Low-load condition. The difference was assessed during the two sessions. The effect of compensatory effort on neurovascular demand was evaluated by examining the interaction between load (High vs. Low) and time (Pre vs. Post). Significant fatigue-induced deactivation (i.e., Pre>Post) was observed in the frontal, temporal, occipital, and parietal cortices, in the cerebellum, and in the midbrain in both the High and Low conditions. The interaction was significantly greater in the High than in the Low condition in the midbrain. Neither significant fatigue-induced activation (i.e., Pre<Post), nor its interaction with factor Load, was identified. The observed midbrain deactivation ([PreH - PostH]>[PreE- PostE]) may reflect suppression of the negative feedback system that normally triggers recuperative rest to maintain homeostasis.

Although many studies have investigated the neural basis of top-down and bottom-up attention, it still requires refinement in both temporal and spatial terms. We used magnetoencephalography to investigate the spatiotemporal dynamics of high-gamma (52-100 Hz) activities during top-down and bottom-up visual attentional processes, aiming to extend the findings from functional magnetic resonance imaging and event-related potential studies. Fourteen participants performed a 3-stimulus visual oddball task, in which both infrequent non-target and target stimuli were presented. We identified high-gamma event-related synchronization in the left middle frontal gyrus, the left intraparietal sulcus, the left thalamus, and the visual areas in different time windows for the target and non-target conditions. We also found elevated imaginary coherence between the left intraparietal sulcus and the right middle frontal gyrus in the high-gamma band from 300 to 400 ms in the target condition, and between the left thalamus and the left middle frontal gyrus in theta band from 150 to 450 ms. In addition, the strength of high-gamma imaginary coherence between the left middle frontal gyrus and left intraparietal sulcus, between the left middle frontal gyrus and the right middle frontal gyrus, and the high-gamma power in the left thalamus predicted inter-subject variation in target detection response time. This source-level electrophysiological evidence enriches our understanding of bi-directional attention processes: stimulus-driven bottom-up attention orientation to a salient, but irrelevant stimulus; and top-down allocation of attentional resources to stimulus evaluation.

Rhythm is an essential element of human culture, particularly in language and music. To acquire language or music, we have to perceive the sensory inputs, organize them into structured sequences as rhythms, actively hold the rhythm information in mind, and use the information when we reproduce or mimic the same rhythm. Previous brain imaging studies have elucidated brain regions related to the perception and production of rhythms. However, the neural substrates involved in the working memory of rhythm remain unclear. In addition, little is known about the processing of rhythm information from non-auditory inputs (visual or tactile). Therefore, we measured brain activity by functional magnetic resonance imaging while healthy subjects memorized and reproduced auditory and visual rhythmic information. The inferior parietal lobule, inferior frontal gyrus, supplementary motor area, and cerebellum exhibited significant activations during both encoding and retrieving rhythm information. In addition, most of these areas exhibited significant activation also during the maintenance of rhythm information. All of these regions functioned in the processing of auditory and visual rhythms. The bilateral inferior parietal lobule, inferior frontal gyrus, supplementary motor area, and cerebellum are thought to be essential for motor control. When we listen to a certain rhythm, we are often stimulated to move our body, which suggests the existence of a strong interaction between rhythm processing and the motor system. Here, we propose that rhythm information may be represented and retained as information about bodily movements in the supra-modal motor brain system.

Automatic mimicry is based on the tight linkage between motor and perception action representations in which internal models play a key role. Based on the anatomical connection, we hypothesized that the direct effective connectivity from the posterior superior temporal sulcus (pSTS) to the ventral premotor area (PMv) formed an inverse internal model, converting visual representation into a motor plan, and that reverse connectivity formed a forward internal model, converting the motor plan into a sensory outcome of action. To test this hypothesis, we employed dynamic causal-modeling analysis with functional magnetic-resonance imaging (fMRI). Twenty-four normal participants underwent a change-detection task involving two visually-presented balls that were either manually rotated by the investigator's right hand ("Hand") or automatically rotated. The effective connectivity from the pSTS to the PMv was enhanced by hand observation and suppressed by execution, corresponding to the inverse model. Opposite effects were observed from the PMv to the pSTS, suggesting the forward model. Additionally, both execution and hand observation commonly enhanced the effective connectivity from the pSTS to the inferior parietal lobule (IPL), the IPL to the primary sensorimotor cortex (S/M1), the PMv to the IPL, and the PMv to the S/M1. Representation of the hand action therefore was implemented in the motor system was suppressed whereas that toward the PMv and S/M1 was enhanced. Thus, the action-representation network acted as a dynamic feedback-control system during action observation.

小児は、外国語音声を獲得するのに適している時期だと考えられているため、小児の外国語音声処理を明らかにすることは、外国語教育において有用である。 我々は、6〜18歳の右利き健常日本人小児を対象に、機能的MRIを用いて、母国語にはない外国語の音声(1音節)を聞いて繰り返して発話する際の脳活動の発達的変化を調べた。本研究の結果から、成人対象の先行研究で、外国語音声を繰り返す際、言語音産出のための運動計画に関与するとされている左側下前頭回弁蓋部の活動が、年齢とともに増加することが分かった。外国語音声の発話精度も年齢とともに向上していたことから、左下前頭回弁蓋部の脳領域の発達が、外国語音声の即座の繰り返しの精度向上に反映している可能性がある。

&lt;p&gt;脳機能計測、特に機能的MRIをAI研究に応用する際に重要な実験デザイン上の考え方を２点提案する。まず１点は適切な統制条件の重要さである。ここでは人間の認知過程の奥深さと解析・解釈の見通しを十分に配慮する必要がある。もう１点は&quot;脳機能も計測してみる&quot;という「追加」的な発想を避けることである。脳機能計測を上手に使う研究コンセプトは３つある。脳機能計測の応用研究は脳機能計測のプロとの恊働が得策である。&lt;/p&gt;

The concept of social self is often described as a representation of the self-reflected in the eyes or minds of others. Although the appearance of one's own face has substantial social significance for humans, neuroimaging studies have failed to link self-face recognition and the likely neural substrate of the social self, the medial prefrontal cortex (MPFC). We assumed that the social self is recruited during self-face recognition under a rich social context where multiple other faces are available for comparison of social values. Using functional magnetic resonance imaging (fMRI), we examined the modulation of neural responses to the faces of the self and of a close friend in a social context. We identified an enhanced response in the ventral MPFC and right occipitoparietal sulcus in the social context specifically for the self-face. Neural response in the right lateral parietal and inferior temporal cortices, previously claimed as self-face-specific, was unaffected for the self-face but unexpectedly enhanced for the friend's face in the social context. Self-face-specific activation in the pars triangularis of the inferior frontal gyrus, and self-face-specific reduction of activation in the left middle temporal gyrus and the right supramarginal gyrus, replicating a previous finding, were not subject to such modulation. Our results thus demonstrated the recruitment of a social self during self-face recognition in the social context. At least three brain networks for self-face-specific activation may be dissociated by different patterns of response-modulation in the social context, suggesting multiple dynamic self-other representations in the human brain. Hum Brain Mapp, 2011. (c) 2011 Wiley-Liss, Inc.

Self-evaluation is affected by facial attractiveness, particularly in females, and may be related to self-esteem. Self-face evaluation is relative to the attractiveness of others ("contrast effect"). In this functional magnetic resonance imaging (fMRI) study, we examined both the neural correlates of self-face evaluation using the contrast effect and a neural relationship between self-face evaluation and self-esteem. We prepared the following three types of "target faces": one's own face (S), a close friend's face (F), and an unfamiliar face (0). They were randomly intermingled among same-sex unfamiliar foils during two block-types. Our intention was to evoke positive evaluations of target faces using unattractive foils in one block-type, and negative evaluations using attractive foils in the other. The posterior cingulate cortex (PCC) and ventral tegmental area (VTA) exhibited greater activation from the positive modulation for S than for O. Activation in these regions was positively correlated with self-esteem and showed the same tendency between S and F. PCC and VTA, which have been implicated in the processing of self-relatedness and reward, respectively, might play a role in the processing of positive self-face evaluation as self-referential stimuli and social rewards, respectively. These results suggested that the PCC and the VTA are the neural correlates of positive self-face evaluation, and that there is a neural relationship between self-face evaluation and self-esteem. The positive evaluation of a close friend's face might be perceived and processed in the same way as one's own face. (C) 2011 Elsevier Inc. All rights reserved.

Mate choice is an example of sophisticated daily decision making supported by multiple componential processes. In mate-choice literature, different characteristics of the value dimensions, including the sex difference in the value dimensions, and the involvement of self-assessment due to the mutual nature of the choice, have been suggested. We examined whether the brain-activation pattern during virtual mate choice would be congruent with these characteristics in terms of stimulus selectivity and activated brain regions. In measuring brain activity, young men and women were shown two pictures of either faces or behaviors, and they indicated which person they would choose either as a spouse or as a friend. Activation selective to spouse choice was observed face-selectively in men's amygdala and behavior-selectively in women's motor system. During both partner-choice conditions, behavior-selective activation was observed in the temporoparietal regions. Taking the available knowledge of these regions into account, these results are congruent with the suggested characteristics of value dimensions for physical attractiveness, parenting resources, and beneficial personality traits for a long-lasting relationship, respectively. The medial prefrontal and posterior cingulate cortices were nonselectively activated during the partner choices, suggesting the involvement of a self-assessment process. The results thus provide neuroscientific support for the multi-component mate-choice mechanism.

The difference between the speed of simple cognitive processes and the speed of complex cognitive processes has various psychological correlates. However, the neural correlates of this difference have not yet been investigated. In this study, we focused on working memory (WM) for typical complex cognitive processes. Functional magnetic resonance imaging data were acquired during the performance of an N-back task, which is a measure of WM for typical complex cognitive processes. In our N-back task, task speed and memory load were varied to identify the neural correlates responsible for the difference between the speed of simple cognitive processes (estimated from the 0-back task) and the speed of WM. Our findings showed that this difference was characterized by the increased activation in the right dorsolateral prefrontal cortex (DLPFC) and the increased functional interaction between the right DLPFC and right superior parietal lobe. Furthermore, the local gray matter volume of the right DLPFC was correlated with participants' accuracy during fast WM tasks, which in turn correlated with a psychometric measure of participants' intelligence. Our findings indicate that the right DLPFC and its related network are responsible for the execution of the fast cognitive processes involved in WM. Identified neural bases may underlie the psychometric differences between the speed with which subjects perform simple cognitive tasks and the speed with which subjects perform more complex cognitive tasks, and explain the previous traditional psychological findings.

This study used functional magnetic resonance imaging (fMRI) to identify differences in the neural processes underlying direct and semidirect interviews. We examined brain activation patterns while 20 native speakers of Japanese participated in direct and semidirect interviews in both Japanese (first language [L1]) and English (second language [L2]). Significantly greater activation was observed in the regions involved in social communication (the medial prefrontal cortex and the bilateral posterior superior temporal sulci) during the direct interview conducted in the L2 than during the semidirect interview conducted in the L2. In contrast, both the direct and semidirect interviews conducted in the L1 produced similar increases in activation in the same brain areas as those observed during the L2 direct interview. These findings suggest that the direct interview may have elicited L2 communicative ability to a greater degree than the semidirect interview. Furthermore, during the L2 direct interview, activity in the right superior temporal region, which is involved in the processing of paralinguistic features (e. g., prosody and intonation), was positively correlated with increased L2 oral proficiency. Based on our findings, we conclude that the L2 direct interview may elicit more balanced and varied aspects of communicative ability than the L2 semidirect interview.

The representation of social interaction in episodic memory is a critical factor for the successful navigation of social relationships. In general, it is important to separate episodic memory during social interaction from episodic memory during the self-generation of action events. Different cortical representations have been associated with social interaction vs. self-generated episodic memory. Here we clarified the cortical representation of the effect of context (social vs. solitary) on episodic memory by comparing it with the generation effect (self vs. other) on episodic memory. Each participant learned words while engaged in a sentence generation and a reading task, and subsequently each participant was scanned with functional magnetic resonance imaging (fMRI) while they performed a recognition task using the words that had been learned. The experiment was comprised of four conditions and we looked at two situations that involved a social context and non-social (solitary) context task. In the learning session before entering the MRI, two participants collaborated in a social context either generating (social-contextual self-generation condition: SS) or reading (social-contextual other-generation condition: SO) a sequence of sentences alternately to construct a meaningful story narrative. In the non-social context, the participants generated (non-social-contextual self-generation condition: NS) or read (non-social-contextual other-generation condition: NO) a sequence of sentences individually. The stimuli for the recognition session consisted of learned words and novel words. Activation for social context retrieval was identified in the right medial prefrontal cortex (mPFC), and activation for self-generated retrieval was identified in the left mPFC and the left middle cingulate cortex. These results indicate that dissociable regions within the medial prefrontal cortices contribute to the processes involved in the representation of social interaction, including social context and self-generation in the retrieval of episodic memory. Published by Elsevier Inc.

Recent functional neuroimaging studies have shown the possibility of decoding human mental states from their brain activity using noninvasive neuroimaging techniques. In this study, we applied multivariate pattern classification, in conjunction with a short interval of functional near-infrared spectroscopy measurements of the anterior frontal cortex, to decode whether a human likes or dislikes a presented visual object; an ability that is quite beneficial for a number of clinical and technological applications. A variety of objects comprising sceneries, cars, foods, and animals were used as the stimuli. The results showed the possibility of predicting subjective preference from a short interval of functional near-infrared spectroscopy measurements of the anterior frontal regions. In addition, the pattern localization results showed the neuroscientific validity of the constructed classifier. NeuroReport 22:269-273 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Special processes recruited during the recognition of personally familiar people have been assumed to reflect the rich episodic and semantic information that selectively represents each person. However, the processes may also include person nonselective ones, which may require interpretation in terms beyond the memory mechanism. To examine this possibility, we assessed decrease in differential activation during the second presentation of an identical face (repetition suppression) as an index of person selectivity. During fMRI, pictures of personally familiar, famous, and unfamiliar faces were presented to healthy subjects who performed a familiarity judgment. Each face was presented once in the first half of the experiment and again in the second half. The right inferior temporal and left inferior frontal gyri were activated during the recognition of both types of familiar faces initially, and this activation was suppressed with repetition. Among preferentially activated regions for personally familiar over famous faces, robust suppression in differential activation was exhibited in the bilateral medial and anterior temporal structures, left amygdala, and right posterior STS, all of which are known to process episodic and semantic information. On the other hand, suppression was minimal in the posterior cingulate, medial prefrontal, right inferior frontal, and intraparietal regions, some of which were implicated in social cognition and cognitive control. Thus, the recognition of personally familiar people is characterized not only by person-selective representation but also by nonselective processes requiring a research framework beyond the memory mechanism, such as a social adaptive response.

皮肉や肯定的発話(ほめや感謝)に対して人々がどのように返答するのかを調べた。その結果、肯定的発話に対しては「謙遜する」「お礼を言う」「肯定する」「笑う」が、皮肉に対しては「あやまる」「苦笑する」が、誤解によるほめに対しては「否定する」「苦笑する」が主要な返答のしかたであることが明らかとなった。また、聞き手の性格特性と返答のしかたの関係についても調べられた。その結果、我々は文脈の違いにより返答のしかたを変化させており、また、性格特性が返答の選択に与える影響も文脈によって異なることが示唆された。

In recent years, the neural substrates underlying outcome feedback processing have been investigated in several neuroimaging studies of feedback-based learning. However, what has been missed in these studies is that, the learning process itself also affects the way the feedback is being processed. In this study, we tried to investigate the changes in neural substrates underlying positive and negative feedback processing during goal-directed implicit learning using the Sugar Production Factory (SPF) task in conjunction with an event related functional magnetic resonance imaging. We found a significant learning-related decrease in activity of the right superior frontal gyrus (SFG) in response to positive feedback and a learning-related increase in activity of the precuneus in response to negative feedback. The results demonstrate the changing role of feedback during learning and suggest that learning-related changes in activity of the SFG and precuneus that have been previously reported in several implicit learning studies arise from changes in feedback processing after learning. In addition, the results suggest the important role of positive feedback in early stage and negative feedback in late stage of goal-directed implicit learning. © Rostami et al.

Human memory systems contain self-monitoring mechanisms for evaluating their progress. People can change their learning strategy on the basis of confidence in their performance at that time. However, it has not been fully understood how the brain is engaged in reliable rating of confidence in past recognition memory performance. We measured the brain activity by fMRI while healthy subjects performed a visual short-term recognition memory test and then rated their confidence in their answers as high, middle, or low. As shown previously, their behavioral performance in the confidence rating widely varied; some showed a positive confidence-recognition correlation (i.e., "rate reliably") while others did not. Among brain regions showing greater activity during rating their confidence relative to during a control, non-metamemory task (discriminating brightness of words), only a posterior-dorsal part of the right frontopolar cortex exhibited higher activity as the confidence level better correlated with actual recognition memory performance. These results suggest that activation in the right frontopolar cortex is key to a reliable, retrospective rating of confidence in short-term recognition memory performance. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Memory for person identity information consists of three main components: face-related information, name-related information, and person-related semantic information, such as the person's job title. Although previous studies have demonstrated the importance of the anterior temporal lobe (ATL) in the retrieval of associations between these kinds of information, there is no evidence concerning whether the ATL region contributes to the encoding of this memory, and whether ATL roles are dissociable between different levels of association in this memory. Using fMRI, we investigated dissociable roles within the ATL during successful encoding of this memory. During encoding, participants viewed unfamiliar faces, each paired with a job title and name. During retrieval, each learned face was presented with two job titles or two names, and participants were required to choose the correct job title or name. Successful encoding conditions were categorized by subsequent retrieval conditions: successful encoding of names and job titles (HNJ), names (HN), and job titles (HJ). The study yielded three main findings. First, the dorsal ATL showed greater activations in HNJ than in HN or HJ. Second, ventral ATL activity was greater in HNJ and HJ than in HN. Third, functional connectivity between these regions was significant during successful encoding. The results are the first to demonstrate that the dorsal and ventral ATL roles are dissociable between two steps of association, associations of person-related semantics with name and with face, and a dorsal-ventral ATL interaction predicts subsequent retrieval success of memory for person identity information.

Second language (12) acquisition necessitates learning and retrieving new words in different modes. In this study, we attempted to investigate the cortical representation of an L2 vocabulary acquired in different learning modes and in cross-modal transfer between learning and retrieval. Healthy participants learned new L2 words either by written translations (text-based learning) or in real-life situations (situation-based learning). Brain activity was then measured during subsequent retrieval of these words. The right supramarginal gyrus and left middle frontal gyrus were involved in situation-based learning and text-based learning, respectively, whereas the left inferior frontal gyrus was activated when learners used L2 knowledge in a mode different from the learning mode. Our findings indicate that the brain regions that mediate L2 memory differ according to how L2 words are learned and used. (C) 2009 Elsevier Inc. All rights reserved.

Agency, a feeling that the self is the-cause of action, has a strong relationship to the processing of discrepancies between the predicted multi-sensory feedback from one&apos;s intended action and its actual outcome (hereafter, agency error). Although previous studies have explored the neural basis of agency by assessing the brain&apos;s response to agency error, the effects found are confounded by two types of error irrelevant to agency: a mismatch between different sensory inputs in general (sensory mismatch, SM error) and a basic response to any type of prediction error (oddball error). In this functional magnetic resonance imaging study. we identified the neural response specific to agency error by dissociating it from responses to SM and oddball errors. Subjects played a game in which they controlled an on-screen character. Neural responses to rare events of violated control and-congruency between types of audio-visual feedback were compared to dissociate agency from SM error. In a separate session, subjects viewed repetitive motions of the character, and neural responses to rare events of unpredictable change in movement were identified as related to oddball error. Agency-error-specific activation was observed in the supplementary motor area (SMA), left cerebellum, right posterior parietal cortex (PPC), and right extrastriate body area (EBA). Oddball errors also activated areas near the PPC and EBA peaks. SM errors activated the pre-SMA and the right posterior superior temporal sulcus. Our results suggest that the SMA, cerebellum, and some parts of the PPC and EBA serve as the neural bases of agency. (C) 2009 Elsevier Inc. All rights reserved.

Motion smoothness is critical in transmitting implicit information of body action, such as aesthetic qualities in dance performances. We expected that the perception of motion smoothness would be characterized by great intersubject variability deriving from differences in personal backgrounds and attitudes toward expressive body actions. We used functional magnetic resonance imaging and a humanoid robot to investigate the effects of the motion smoothness of expressive body actions and the intersubject variability due to personal attitudes on perceptions during dance observation. The effect of motion smoothness was analyzed by both conventional subtraction analysis and functional connectivity analyses that detect cortical networks reflecting intersubject variability. The results showed that the cortical networks of motion- and body-sensitive visual areas showed increases in activity in areas corresponding with motion smoothness, but the intersubject variability of personal attitudes toward art did not influence these active areas. In contrast, activation of cortical networks, including the parieto-frontal network, has large intersubject variability, and this variability is associated with personal attitudes about the consciousness of art. Thus, our results suggest that activity in the cortical network involved in understanding action is influenced by personal attitudes about the consciousness of art during observations of expressive body actions.

Daily situations involve many objects and behaviors. To comprehend the meaning of situations, the relationships between objects, behaviors, and the situational context are important. To reveal the cortical networks involved in processing these relationships we used functional magnetic resonance imaging to compare brain activation during processing of behavior-situation and object-situation relationships. Each session examined two aspects of situational relationship processing: monitoring of the situational relationship and responses to irrelevant relationships. Monitoring was analyzed by comparing cortical activation during a situational relevance judgment task with that during a physical appropriateness judgment task. Responses were analyzed by comparing neural responses to situationally irrelevant and situationally relevant components. The left medial frontal cortex, fusiform gyrus, inferior frontal gyrus, calcarine sulcus, right anterior middle temporal gyrus, orbitoinsular junction, and occipito-temporo-parietal junction were commonly activated while monitoring relationships of both types. The right anterior middle temporal gyrus and orbitoinsular junction were considered to have roles in implicit monitoring because they were more deactivated during physical judgment tasks than during the resting state; this deactivation seemed to reflect unconscious situational monitoring in the resting state. Other regions seemed to be linked to explicit conscious monitoring. Responses to irrelevance were linked to separate and category-specific cortical activation in the left medial frontal cortex and frontal pole for behavioral irrelevance and in the left orbitofrontal cortex for irrelevant objects. We demonstrated that the hierarchical structure of processing situational relationships consisted of implicit monitoring, explicit monitoring, and category-specific responses to irrelevance. (C) 2009 Elsevier Inc. All rights reserved.

Person recognition has been assumed to entail many types of person-specific cognitive responses, including retrieval of knowledge, episodic recollection, and emotional responses. To demonstrate the cortical correlates of this modular structure of multimodal person representation, we investigated neural responses preferential to personally familiar people and responses dependent on familiarity with famous people in the temporal and parietal cortices. During functional magnetic resonance imaging (fMRI) measurements, normal subjects recognized personally familiar names (personal) or famous names with high or low degrees of familiarity (high or low, respectively). Effects of familiarity with famous people (i.e., high-low) were identified in the bilateral angular gyri, the left supramarginal gyrus, the middle part of the bilateral posterior cingulate cortices, and the left precuneus. Activation preferentially relevant to personally familiar people (i.e., personal-high) was identified in the bilateral temporo-parietal junctions, the right anterolateral temporal cortices, posterior middle temporal gyrus, posterior cingulate cortex (with a peak in the posterodorsal part), and the left precuneus; these activation foci exhibited varying degrees of activation for high and low names. An equivalent extent of activation was observed for all familiar names in the bilateral temporal poles, the left orbito-insular junction, the middle temporal gyrus, and the anterior part of the posterior cingulate cortex. The results demonstrated that distinct cortical areas supported different types of cognitive responses, induced to different degrees during recognition of famous and personally familiar people, providing neuroscientific evidence for the modularity of multimodal person representation.

Several neuropsychological and neuroimaging studies have been performed to clarify the neural bases of implicit learning, but the question of which brain regions are involved in different forms of implicit learning, including goal-directed learning and habit learning, has not yet been resolved. The present study sought to clarify the mechanisms of goal-directed implicit learning by examining the sugar production factory (SPF) task in conjunction with functional magnetic resonance imaging (fMRI). Several brain regions were identified that contribute to learning in the SPF task. Significant learning-related decreases in brain activity were found in the right inferior parietal lobule (IPL), left superior frontal gyrus, right medial frontal gyrus, cerebellar vermis, and left inferior frontal gyrus, while significant learning-related increases in activity were observed in the right inferior frontal gyrus, left precenteral gyrus and, left precuneus. Among these regions, we speculate that the IPL and medial frontal gyrus may specifically be involved in the early stage of goal-directed implicit learning. We also attempted to investigate the role of the striatum, which has a significant role in habit learning, during learning of the SPF task. The results of ROI analysis showed no learning-related change in the activity of the striatum. Although some of the observed learning-related activations in this study have also been previously reported in neuroimaging studies of habit learning, the possibility that specific brain regions involved in goal-direct implicit learning cannot be excluded. (C) 2009 Elsevier Inc. All rights reserved.

Humans extract behaviorally significant meaning from a situation by integrating meanings from multiple components of a complex daily environment. To determine the neural underpinnings of this ability, the authors performed functional magnetic resonance imaging of healthy subjects while the latter viewed naturalistic scenes of two people and an object, including a threatening situation of a person being attacked by an offender with an object. The authors Used a two-factorial design: the object was either aversive or nonaversive, and the offender&apos;s action was either directed to the person or elsewhere. This allowed the authors to examine the neural response to object aversiveness and person-directed intention separately. A task Unrelated to threat was also Used to address incidental (i.e., subconscious or unintentional) detection. Assuming individual difference,, in incidental threat detection, the authors used a functional connectivity analysis using principal components analysis of intersubject variability. The left lateral orbitofrontal cortex and medial prefrontal cortex (MPFC) were specifically activated in response to a threatening situation. The threat-related component of intersubject variability was extracted from these data and showed a significant correlation with personality scores. There was also a correlation between threat-related intersubject variability and activation for object aversiveness in the left temporal pole and lateral orbitofrontal cortex; person-directed intention in the left superior frontal gyrus; threatening situations in the left MPFC; and independently for both factors in the right MPFC, Results demonstrate independent processing of object aversiveness and person-directed intention in the left temporal-orbitofrontal and superior frontal networks, respectively, and their integration into situational meaning in the MPFC. Hum Brain Mapp 30:2676-2688, 2009. (C) 2008 Wiley-Liss, Inc.

This study examined the neural basis underlying the sequential involvement of sentence processing and determined the point at which the processing cost for an object-initial sentence was observed. We presented each phrase in a Japanese object-initial sentence to Japanese participants one by one using an event-related functional MRI technique and compared with our previous subject-initial experiment. We found that the left lingual gyrus was activated upon presentation of the first noun phrases, and the left inferior frontal gyrus upon presentation of the second noun phrases. The processing cost for an object-initial sentence was observed during verb recognition. Our results suggest that the syntactic complexity of an object-initial sentence is processed by the human brain upon verb recognition. NeuroReport 20:531-535 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

During narrative comprehension, readers understand the emotions of the protagonist by taking the perspective of the character, which is an essential component of empathy. Spatial perspective-taking is crucial to understanding the standpoints and perceptions of others, and gives clues as to what the protagonist knows. As a default, a "here and now" point-of-view is adopted to make sense of the narrative. If the protagonist is in a different location while an event takes place ("there and now"), in order to comprehend the narrative the reader must take an allocentric perspective, which places greater demands on spatial perspective-taking. Utilizing this phenomenon, we evaluated the neural substrates of perspective-taking in emotional narrative comprehension using functional MRI in 18 normal adults. The subjects read short stories followed by a target sentence, which described an event that might evoke an emotional response in the protagonist if the character were present. The stories involved a scenario in which the character was either present at the same location ("here and now") or at a distant location ("there and now") during the event. The "there and now" scenario activated the posterior cingulate cortex and the right temporoparietal junction more prominently than the "here and now" condition. In contrast to the control tasks, both scenarios activated the well-known mentalizing network including the dorsomedial prefrontal cortex, temporal pole, posterior cingulate cortex and temporo-parietal junction. Along with the mentalizing network, the posterior cingulate cortex and the right temporo-parietal junction are involved in spatial perspective-taking during emotional narrative comprehension. (C) 2008 Elsevier Ltd. All rights reserved.

Despite the huge number of studies on control-display compatibility conducted over the past fifty years, there are still debates concerning the efficacy of conventional measures such as subjective evaluation and performance measures for discriminating between compatible and incompatible control-display mappings. Since compatibility refers to the control-display relationship corresponding to mental model of the users, we tried to apply functional neuroimaging technique as a direct objective measure for analyzing cognitive factors involved in human-machine interaction (HMI). Functional Magnetic Resonance Imaging (fMRI) was applied in order to analyze rotary control-linear display movement compatibility for horizontal and vertical linear displays. Although the results of behavioral measures were not significantly different for incompatible and compatible control-display mappings, neuroimaging results were quite successful in discriminating between them. Moreover, the fMRI results showed significantly greater brain activity for the incompatible condition than for the compatible one in the left posterior cingulate and the right interior temporal gyrus that reveals the involvement of a greater cognitive load in terms of attention and visuomotor transformation in the incompatible condition. The results of this study suggest that neuroimaging method is a good complement to conventional measures and is quite helpful to acquire a better understanding of the cognitive processes involved in HMI.

Mirror-symmetrical bimanual movement is more stable than parallel bimanual movement. This is well established at the kinematic level. We used functional MRI (fMRI) to evaluate the neural substrates of the stability of mirror-symmetrical bimanual movement. Right-handed participants (n = 17) rotated disks with Akaike causality model to both kinematic and fMRI time-series data. We hypothesized that kinematic stability is represented by the extent of neural "cross-talk": as the fraction of signals that are common to controlling both hands increases, the stability also increases. The standard deviation of the phase difference for the mirror mode was significantly smaller than that for the parallel mode, confirming that the former was more stable. We used the noise-contribution ratio (NCR), which was computed using a multivariate autoregressive model with latent variables, as a direct measure of the cross-talk between both the two hands and the bilateral primary motor cortices (M1s). The mode-by-direction interaction of the NCR was significant in both the kinematic and fMRI data. Furthermore, in both sets of data, the NCR from the right hand (left M I) to the left (right M I) was more prominent than vice versa during the mirror-symmetrical mode, whereas no difference was observed during parallel movement or rest. The asymmetric interhemispheric interaction from the left M I to the right M I during symmetric bimanual movement might represent cortical-level crosstalk, which contributes to the stability of symmetric bimanual movements. (C) 2008 Elsevier Inc. All rights reserved.

The ability of visual self- recognition in animals and infants is considered a hallmark of the domain-general cognitive representation of the self, which also underpins higher social ability. Cortical regions activated during self-face recognition in human adults have been accordingly expected to play the domain-general role in self-processing. However, there is no evidence of the involvement of this network in non-face domains. We compared cortical responses during face and name recognition of self, a friend, and an unfamiliar person, using functional magnetic resonance imaging (fMRI). Recognition of the self-face activated the right inferior frontal, precentral, supramarginal, and bilateral ventral occipitotemporal regions, consistent with previous findings, whereas these regions did not show self-specific activation during name recognition. During both face and name recognitions, increased activation for the friend and unfamiliar person than for the self was observed in the bilateral temporoparietal regions, and higher activation for the self and friend than for the unfamiliar person was observed in the medial cortical structures. These results suggest that the role of the self-specific networks during face recognition is not domain-general, but rather face-specific, and that the medial cortical structures, which are also implicated in self-referential processes, are not relevant to self-other distinction during face or name recognition. Instead, the reduced temporoparietal activation is a domain-general characteristic of the cortical response during self- recognition, which may reflect suppression of an automatic preparatory process for social interaction, possibly paralleling the disappearance of social behavior to the mirrored self-image at the emergence of self- recognition in animals and infants. (c) 2008 Elsevier Inc. All rights reserved.

One of human-being specific activities, interpreting (oral translation), has been adopted as a popular method to enhance second language acquisition lately. The question, however, how interpreting is executed in human brains, remains largely unknown. In this paper, we present our fMRI (functional Magnetic Resonance Imaging) experimental results to investigate how cerebral cortices are activated when subjects are engaged in interpreting exercises. Twenty-one healthy, right-handed university student subjects participated in this study. We directly compared English to Japanese consecutive inte...

The purpose of this study was to identify the neural correlates of psychosocial maturity during understanding others from the viewpoint of self. In psychology, ego identity is one of the most famous theories for psychosocial maturity. Those who have established ego identity have a definite purpose for one&#039;s life and an ability of goal directed behavior. We assumed that such a psychosocial maturity is related to the ability to distinguish others from self when one understands the others. We used an fMRI technique to identify cortical regions where activity during understanding others&#039; decision-making is correlated with personality maturity. We measured subjects&#039; personality maturity using the Rasmussen&#039;s Ego Identity Scale. There were three conditions, S, F and G which were perspective taking conditions for inferring self, best friend and people in general&#039;s decision-making, respectively. Differential activation of both the contrasts F-S and G-S was significantly correlated with the ego identity scale in the left lateral prefrontal cortex (LPFC). The results indicate that the activity of the left LPFC is related to psychosocial maturity when understanding others from the viewpoint of self. We suggest that psychosocial maturity is related to the development of the executive function which is supported by the left LPFC. &lt;b&gt;[J Physiol Sci. 2008;58 Suppl:S30]&lt;/b&gt;

Phylogenetical and ontogenetical evidence suggests that visual self-recognition requires cognitive mechanisms that are partially distinct from those for recognition of other person, but closely related to a higher social cognition ability, such as empathy. Recent functional imaging studies demonstrated a pattern of cortical activation observed specifically during the recognition of one&#039;s own face. A characteristic of the pattern includes an absence of activation in the temporoparietal regions, which is observed during other-face recognition, and has been implicated in social perception. Given that this pattern has been replicated in the self-name recognition, the lack of the involvement of the social perception network seems to be a domain-general characteristic of self-recognition. On the other hand, several cortical regions, predominantly in the right parietal and frontal cortices, exhibit activation specifically during the self-face but not self-name recognition. While these regions have been typically associated with the sensorimotor integration, results of a functional connectivity analysis on intersubject variability in activation suggested that the right parietal and frontal networks play distinct roles in self-face recognition. Taking these findings together, cortical activation specific to the self-face appears to reflect self-other distinction at multiple levels, at least including physical and social levels. &lt;b&gt;[J Physiol Sci. 2008;58 Suppl:S29]&lt;/b&gt;

Humans can often conduct both linear and nonlinear control tasks after a sufficient number of trials, even if they initially do not have sufficient knowledge about the system's dynamics and the way to control it. Theoretically, it is well known that some nonlinear systems cannot be stabilized asymptotically by any linear controllers. However, such differences between linear and nonlinear controls from the viewpoint of brain activities are still unclear. In this paper, we have conducted an f-MRI experiment using complex nonlinear control tasks where subjects are required to control a 2-link planer under actuated manipulator (2PUAM). The 2PUAM has nonholonomic constrains and cannot be stabilized asymptotically by any linear controller. Although there are similar activations such as in motor cortex and somatosensory cortex, some differences between linear and nonlinear cases have been observed by the f-MRI. According to the brain function mapping, the result implies that some additional information such as the shape of the manipulator and its trajectory, which are not needed for linear control tasks, may be required to control the 2PUAM. Therefore, this suggests that the difference in linear and nonlinear control tasks can be observed through the brain activities.

To determine the effect of robotic embodiment on human-robot interaction, we used functional magnetic resonance imaging (fMRI) to measure brain activity during the observation of emotionally positive or neutral actions performed by bipedal or wheel-drive humanoid robots. fMRI data from 30 participants were analyzed in the study. The results revealed that bipedal humanoid robot performing emotionally positive actions induced the activation of the left orbitofrontal cortex, which is associated with emotional empathy, whereas wheel-drive humanoid robot performing the same actions elicited a lesser response. These results demonstrate that humans more readily empathize with a bipedal humanoid robot based on the ability to simulate human-like body movements.

To understand implicit social meanings, the interaction of literal meanings and relevant information in a situational context is important. However, previous studies have not investigated such contextual interactions. Using functional magnetic resonance imaging (fMRI), we investigated cortical mechanisms underlying the processing of implicit meanings, particularly irony, in realistic social situations, focusing on contextual interactions. Healthy subjects were shown pictures depicting daily communicative situations during judgment tasks involving situational appropriateness and literal correctness. The left medial prefrontal cortex showed significantly greater activation during tasks involving situational judgments than during literal judgments. The right temporal pole was activated task-independently during irony-specific processing. The medial orbitofrontal cortex was activated task-dependently during irony processing in situational judgment tasks. These regions have been reported to be involved in theory of mind, and have not been implicated in previous studies on the linguistic processing of implicit meanings. This suggests that the intentional assessment of situational appropriateness for task execution is carried out in the left medial prefrontal cortex, whereas irony is processed in the right temporal pole by assessing situational context automatically, and is judged based on the situational context in the medial orbitofrontal cortex. Our results show that the processing of implicit meanings and irony in contextually rich situations depends on brain mechanisms involved in the "theory of mind," based on processing relevant information in a situational context, and suggest different functions in each region. (C) 2007 Elsevier Inc. All rights reserved.

Communicative speech requires conformity not only to linguistic rules but also to behavior that is appropriate for social interaction. The existence of a special brain mechanism for such behavioral aspects of communicative speech has been suggested by studies of social impairment in autism, and it may be related to communicative vocalization in animals. We used functional magnetic resonance imaging (fMRI) to measure cortical activation while normal subjects casually talked to an actor (communication task) or verbally described a situation (description task) while observing video clips of an action performed by a familiar or an unfamiliar actor in a typical daily situation. We assumed that the communication task differed from the description task in the involvement of behavioral aspects of communicative speech production, which may involve the processing of interaction-relevant biographical information. Significantly higher activation was observed during the communication task than during the description task in the medial prefrontal cortex (polar and dorsal parts), the bilateral anterior superior temporal sulci, and the left temporciparietal junction. The results suggest that these regions play a role in the behavioral aspects of communicative speech production, presumably in understanding of the context of the social interaction. The activation of the polar part of the medial prefrontal cortex during the communication task was greater when the actor was familiar than when the actor was unfamiliar, suggesting that this region is involved in communicative speech production with reference to biological information. The precuneus was activated during the communication task only with the familiar actor, suggesting that this region is related to access to biographical information per se. (c) 2007 Elsevier Inc. All rights reserved.

The goal of this study was to examine the effect of the linguistic distance between a first language (L1) and a second language (L2) on neural activity during second language relative to first language processing. We compared different L1-L2 pairs in which different linguistic features characterize linguistic distance. Chinese and Korean native speakers were instructed to perform sentence comprehension tasks in two L2s (English and Japanese) and their respective L1s. Activation while understanding English sentences relative to understanding sentences in L1 was greater for the Korean group than the Chinese group in the left inferior frontal gyrus, bilateral posterior superior temporal gyri, and right cerebellum. Activation while understanding Japanese sentences relative to understanding sentences in L1 was greater for the Chinese group than the Korean group in the anterior portion of the left superior temporal gyrus. The results demonstrated that the location of the L2-L1 processing-induced cortical activation varies between different L1-L2 pairs.

In this study of native Korean trilinguals we examined the effect of syntactic similarity between first (L1) and second (L2) languages on cortical activation during the processing of Japanese and English, which are, respectively, very similar to and different from Korean. Subjects had equivalent proficiency in Japanese and English. They performed auditory sentence comprehension tasks in Korean, Japanese, and English during functional MRI (fMRI). The bilateral superior temporal cortex was activated during the comprehension of three languages. The pars triangularis of the left inferior frontal gyrus (IFG) was additionally activated for L2 processing. Furthermore, the right cerebellum, the pars opercularis of the left IFG, and the posteriomedial part of the superior frontal gyrus were activated during the English tasks only. We observed significantly greater activation in the pars opercularis of the left IFG, the right cerebellum, and the right superior temporal cortex during the English than Japanese task; activation in these regions did not differ significantly between Korean and Japanese. Differential activation of the pars opercularis of the left IFG and the right cerebellum likely reflects syntactic distance and differential activation in the right superior temporal cortex may reflect the prosodic distance between English from Korean and Japanese. Furthermore, in the pars oparcularis of the left IFG and the right cerebellum, significant negative correlation between the activation and duration of exposure was observed for English, but not for Japanese. Our research supports the notion that linguistic similarity between L1 and L2 affects the cortical processing of second language.

Since the brain may engage different neuronal systems for a single behavioral goal, activation may show intersubject variability expressed in the systematic recruitment of multiple distinct networks. We apply a principal component analysis (PCA) to activation over task conditions and subjects to reveal cortical networks that may underlie this intersubject variability. Normal subjects were presented with novel meaningless objects, which appeared in personally familiar or unfamiliar places. During a subsequent, event-related functional MRI (fMRI) experiment, each subject was presented with learned or novel objects in isolation and performed a learned/novel judgment. Recollection of places was not essential for the task, and may exhibit large intersubject variations. The right posterodorsal posterior cingulate cortex (pPCC) and left retrosplenial cortex, whose involvement in place-recognition has been previously established, were selected as regions of interest for the PCA. Neural responses to objects associated with familiar relative to unfamiliar places in pPCC, but not in the retrosplenial cortex, were negatively correlated with task-related activation (common over all objects) in the right anterolateral prefrontal cortex and the left intraparietal sulcus. The latter areas have been implicated previously in cognitive control and object recognition, respectively. These results suggest right prefrontal control over neural processes both in the left parietal cortex, related to object-recognition (enhancement), and pPCC, related to nonessential recollection of place-memory (suppression), but not in the retrosplenial cortex, related to the sense of familiarity. This analysis revealed an important aspect of functional anatomy that was not detectable using a conventional analysis of average activations.

Multiple brain networks may support visual self-recognition. It has been hypothesized that the left ventral occipito-temporal cortex processes one's own face as a symbol, and the right parieto-frontal network processes self-image in association with motion-action contingency. Using functional magnetic resonance imaging, we first tested these hypotheses based on the prediction that these networks preferentially respond to a static self-face and to moving one's whole body, respectively. Brain activation specifically related to self-image during familiarity judgment was compared across four stimulus conditions comprising a two factorial design: factor Motion contrasted picture (Picture) and movie (Movie), and factor Body part a face (Face) and whole body (Body). Second, we attempted to segregate self-specific networks using a principal component analysis (PCA), assuming an independent pattern of inter-subject variability in activation over the four stimulus conditions in each network. The bilateral ventral occipito-temporal and the right parietal and frontal cortices exhibited self-specific activation. The left ventral occipito-temporal cortex exhibited greater self-specific activation for Face than for Body, in Picture, consistent with the prediction for this region. The activation profiles of the right parietal and frontal cortices did not show preference for Movie Body predicted by the assumed roles of these regions. The PCA extracted two cortical networks, one with its peaks in the right posterior, and another in frontal cortices; their possible roles in visuo-spatial and conceptual self-representations, respectively, were suggested by previous findings. The results thus supported and provided evidence of multiple brain networks for visual self-recognition. (c) 2006 Elsevier Inc. All rights reserved.

Personally familiar people are likely to be represented more richly in episodic, emotional, and behavioral contexts than famous people, who are usually represented predominantly in semantic context. To reveal cortical mechanisms supporting this differential person representation, we compared cortical activation during name recognition tasks between personally familiar and famous names, using an event-related functional magnetic resonance imaging (MRI). Normal subjects performed familiar- or unfamiliar-name detection tasks during visual presentation of personally familiar (Personal), famous (Famous), and unfamiliar (Unfamiliar) names. The bilateral temporal poles and anterolateral temporal cortices, as well as the left temporoparietal junction, were activated in the contrasts Personal-Unfamiliar and Famous-Unfamiliar to a similar extent. The bilateral occipitotemporoparietal junctions, precuneus, and posterior cingulate cortex showed activation in the contrasts Personal-Unfamiliar and Personal-Famous. Together with previous findings, differential activation in the occipitotemporoparietal junction, precuneus, and posterior cingulate cortex between personally familiar and famous names is considered to reflect differential person representation. The similar extent of activation for personally familiar and famous names in the temporal pole and anterolateral temporal cortex is consistent with the associative role of the anterior temporal cortex in person identification, which has been conceptualized as a person identity node in many models of person identification. The left temporoparietal junction was considered to process familiar written names. The results illustrated the neural correlates of the person representation as a network of discrete regions in the bilateral posterior cortices, with the anterior temporal cortices having a unique associative role. (c) 2006 Elsevier Inc. All rights reserved.

The purpose of this study is to determine, by functional magnetic resonance imaging, how the activated regions of the brain change as a Japanese sentence is presented in a grammatically correct order. In this study, we presented constituents of a sentence to Japanese participants one by one at regular intervals. The results showed that the left lingual gyrus was significantly activated at the beginning of the sentence, then the left inferior frontal gyrus and left supplementary motor area, in the middle of the sentence, and the left inferior temporal gyrus, at the end of the sentence. We suggest that these brain areas are involved in sentence comprehension in this temporal order. © 2005 Elsevier Inc. All rights reserved.

Paced Serial Addition Test (PSAT) was used as one of the neuropsychological assessment tools. In the PSAT, stimulus presentation rate was varied under several conditions, and known that the number of correct responses decreases with the increase in stimulus presentation rate. In the present study, we examined brain activation correlated with the change in stimulus presentation rate during the Paced Visual Serial Addition Test (PVSAT) by functional magnetic resonance imaging (fMRI). The Simple Addition Test (SAT) was used as a control task. The results showed significantly greater activations in the right dorsolateral prefrontal cortex, bilateral dorsal premotor cortex, bilateral precentral gyrus, supplementary motor area, left inferior parietal lobule, right superior parietal lobule, bilateral precuneus, right anterior cingulate gyros, left caudate nucleus, and the bilateral cerebellum during the PVSAT than during the SAT, independent of the change in stimulus presentation rate. These areas are considered to be related working memory or the attention process during the PVSAT. Among these regions, the right dorsolateral prefrontal cortex, left premotor cortex and the left precuneus showed positively correlated activation with the increase in stimulus presentation rate during the PVSAT, but not during the SAT. These three areas may consist of brain network(s) involved in updating or manipulating information in working memory.

The recognition of both personally familiar objects and places involves nonspatial memory retrieval processes, but only personally familiar places are represented as space. Although the posterior cingulate cortex (PCC) is considered to process both types Of Such memories, its functional organization is poorly understood. In this event-related fMRI study, normal subjects judged familiar/unfamiliar pictures in four categories: familiar places (FP), familiar objects (170), unfamiliar places (UP), and unfamiliar objects (UO), thus constituting a two-factorial design. A significant main effect of stimuli with greater activation in the place (FP and UP) than object (FO and UO) trials was observed bilaterally in several medial temporo-occipito-parietal regions, including the caudal PCC (cPCC) and parahippocampal gyrus. The reverse comparison revealed greater activation in the lateral inferior occipito-temporal junctions and intraparietal sulci bilaterally. A significant main effect of familiarity with greater activation in the familiar (FP and FO) than unfamiliar (UP and UO) trials was observed in the mid-dorsal PCC mPCC, retrosplenial cortex, posterior precuneus, and the left intraparietal sulcus. Activation specific to the FP trials (as assessed by the interaction) was observed in the right posterodorsal PCC (pPCC) only. Together with data from previous functional imaging studies, the results suggest a functional segregation of human PCC with differential involvement of pPCC in spatial representations of personally familiar places and of the mPCC and retrosplenial cortex in episodic retrieval of personally familiar places and objects. Activation of the left intrapariltal sulcus may reflect retrieval of memories related to object manipulation.

Several lines of evidence have suggested that visual self-recognition is supported by a special brain mechanism; however, its functional anatomy is of great controversy. We performed an event-related functional magnetic resonance imaging (fMRI) study to identify brain regions selectively involved in recognition of one's own face. We presented pictures of each subject's own face (SELF) and a prelearned face of an unfamiliar person (CONT), as well as two personally familiar faces with high and low familiarity (HIGH and LOW, respectively) to test selectivity of activation to the SELF face. Compared with the CONT face, activation selective to the SELF face was observed in the right occipito-temporo-parietal junction and frontal operculum, as well as in the left fusiform gyrus. On the contrary, the temporoparietal junction in both the hemispheres and the left anterior temporal cortex, which were activated during recognition of HIGH and/or LOW faces, were not activated during recognition of the SELF face. The results confirmed the partial distinction of the brain mechanism involved in recognition of personally familiar faces and that in recognition of one's own face. The right occipito-temporo-parietal junction and frontal operculum appear to compose a network processing motion-action contingency, a role of which in visual self-recognition has been suggested in previous behavioral studies. Activation of the left fusiform gyrus selective to one's own face was consistent with the results of two previous functional imaging studies and a neuropsychological report, possibly suggesting its relationship with lexical processing. (C) 2004 Elsevier Inc. All rights reserved.

Mental visual synthesis is the capacity for experiencing, constructing, or manipulating 'mental imagery'. To investigate brain networks involved in mental visual synthesis, brain activity was measured in right-handed healthy volunteers during mental imagery tasks, in which the subjects were instructed to imagine a novel object, that does not exist in the real world, by composing it from two visually presented words associated with a real object or two achromatic line drawings of a real object, using functional magnetic resonance imaging (fMRI). Both tasks activated the same areas in the inferior frontal and inferior temporal cortices of the left hemisphere. Our results indicate that the source of mental visual synthesis may be formed by activity of a brain network consisting of these areas, which are also involved in semantic operations and visual imagery.

Although involvement of the frontoparietal regions in visually guided saccade and visuospatial attention has been established, functional difference of the frontal and parietal regions suggested in neuropsychological observations and lesion studies in animals has not been explicitly supported by functional imaging studies. Considering a possible disadvantage of cognitive subtraction in an interregional comparison, we directly compared the time course of BOLD signal changes across regions. Normal subjects performed a modified version of a memory-guided saccade task in which saccade was performed both during encoding and execution phases. In addition, the delay period was fixed and the peripheral target was presented also during the execution phase together with distracters. Therefore, visuospatial representation was likely maintained in the sensory domain during the delay phase. A principal component analysis on the time-course data separated the 20 activated areas into three groups, which largely coincided with the cerebral lobes. The frontal group included the putative human FEF and SEF, and the parietal group PER The frontal and occipital groups exhibited the time course of activation with two peaks corresponding to neural responses during the encoding and execution phases, and the parietal group exhibited a single-humped activation pattern corresponding to neural activity during the delay phase. The results suggest that the frontal regions are more associated with the execution of saccade, and the parietal regions with visuospatial representation, presumably in the sensory domain. (C) 2004 Wiley-Liss, inc.

The human tongue is so sensitive and dexterous that spatial representations of the inside of the oral cavity for the tongue movement are naturally expected to exist. In the present study, we examined the brain activity associated with spatial processing during tongue movements using a functional magnetic resonance imaging technique. Twenty-four normal subjects participated in the study, which consisted of a periodic series of three blocks; resting of the tongue, tongue movement (pressing the inside of a tooth with the tip of the tongue), and tongue retraction. The cerebral fields of activation during the tongue movement to the left and right side relative to those during rest were found in the primary sensorimotor area and supplementary motor area bilaterally, and in the left inferior parietal lobule (IPL). The activation areas during the tongue retraction relative to those during rest were almost the same, except that activation in the left IPL was not observed. The fields of activation during tongue movement to the left and right side relative to those during tongue retraction were found bilaterally in the dorsal premotor area, superior parietal lobule (SPL), and the IPL. The results indicate that the bilateral SPL and IPL were specifically involved in the processing for human tongue movement. Although no significant laterality was observed, the left parietal area tended to show greater activation in statistical values and area than the right parietal area, thus indicating the possibility that this processing for human tongue movement is related to that for language. © 2004 Elsevier Inc. All rights reserved.

The cognitive mechanism for inference of personal dispositions, such as personality traits and abilities, is postulated to be dependent on the amount of episodic memory concerning target persons. To examine whether there is such target dependency in the brain mechanism during dispositional inference, we measured brain activity of normal volunteers while they were performing seven dispositional inference tasks, each for a target person in different categories, using positron emission tomography (PET). Effect of the target-person category on activation was significant in the posterodorsal, polar, and ventral subdivisions of medial prefrontal cortex, right orbitoinsular junction, left temporal pole and superior temporal sulcus, cerebellum, and thalamus, suggesting the existence of target dependency in activation during dispositional inference. The amount of episodic memory concerning a target person measured using the self-evaluative questionnaire was positively correlated with the activation in the polar subdivision of the medial prefrontal cortex, and negatively with that in a region in the left superior temporal sulcus. Together with the available knowledge on the functional roles of these regions and the proposed cognitive model in social psychology, our results suggest that these two regions play roles supplementary to each other in dispositional inference; a region in the superior temporal sulcus is involved in the processing of relevant episodic exemplar and the polar subdivision of the medial prefrontal cortex in the processing of summarized value information about the target person. (C) 2004 Elsevier Inc. All rights reserved.

The purpose of this study was to investigate human brain activity during the reading aloud of Japanese sentences using fMRI. Twenty-three right-handed normal Japanese subjects performed three reading tasks: covert reading of meaningful or meaningless sentences, and reading aloud of meaningful sentences. Areas in the bilateral frontal and temporal cortices were activated during the reading-aloud task compared with the covert reading task. In addition, activation of these brain areas showed significant positive correlation with the reading speed during the reading-aloud task. Our results indicate that bilateral frontal-temporal networks are involved in phonological processing during reading aloud. © 2003 Lippincott Williams &amp; Wilkins.

本研究は、functionarl Magnetic Resonance Imaging(fMRI)を用いて、聴覚言語理解時の統語関係の理解と意味理解に関わる脳の領域を探ることが目的である。被験者には、正しい文、文法の誤った文、意味が不自然な文をランダムに聞かせそれぞれの文の正誤判断をさせた。その結果左半球の中前頭回、下前頭回、下頭頂小葉に共通に有意な脳の賦活化が観察された。また、文法の誤った文を聞いた時は、下頭頂小葉が最も有意に、一方、意味の不自然な文を聞いた時は、下前頭回が最も有意に脳の賦活化した。以上のことから、文の「誤り」「不自然さ」に関わる領域について、文法情報処理と意味情報処理はそれぞれ異なる領域で行われているというよりはむしろ、前頭連合野から頭頂連合野のネットワークを用い、相補的に処理が行われている可能性が示唆された。

本研究は、functionarl Magnetic Resonance Imaging(fMRI)を用いて、聴覚言語理解時の統語関係の理解と意味理解に関わる脳の領域を探ることが目的である。被験者には、正しい文、文法の誤った文、意味が不自然な文をランダムに聞かせそれぞれの文の正誤判断をさせた。その結果左半球の中前頭回、下前頭回、下頭頂小葉に共通に有意な脳の賦活化が観察された。また、文法の誤った文を聞いた時は、下頭頂小葉が最も有意に、一方、意味の不自然な文を聞いた時は、下前頭回が最も有意に脳の賦活化した。以上のことから、文の「誤り」「不自然さ」に関わる領域について、文法情報処理と意味情報処理はそれぞれ異なる領域で行われているというよりはむしろ、前頭連合野から頭頂連合野のネットワークを用い、相補的に処理が行われている可能性が示唆された。

One of the important roles of the prefrontal cortex is inhibition of movement. We applied an event-related functional magnetic resonance imaging (fMRI) technique to observe changes in fMRI signals of the entire brain during a GO/NO-GO task to identify the functional fields activated in relation to the NO-GO decision. Eleven normal subjects participated in the study, which consisted of a random series of 30 GO and 30 NO-GO trials. The subjects were instructed to press a mouse button immediately after the GO signal was presented. However, they were instructed not to move when the NO-GO signal was presented. We detected significant changes in MR signals in relation to the preparation phases, GO responses, and NO-GO responses. The activation fields related to the NO-GO responses were located in the bilateral middle frontal cortices, left dorsal premotor area, left posterior intraparietal cortices, and right occipitotemporal area. The fields of activation in relation to the GO responses were found in the left primary sensorimotor, right cerebellar anterior lobule, bilateral thalamus, and the area from the anterior cingulate to the supplementary motor area (SMA). Brain activations related to the preparation phases were identified in the left dorsal premotor, left lateral occipital, right ventral premotor, right fusiform, and the area from the anterior cingulate to the SMA. The results indicate that brain networks consisting of the bilateral prefrontal, intraparietal, and occipitotemporal cortices may play an important role in executing a NO-GO response. © 2002 Elsevier Science (USA).

The changes of regional cerebral blood flow (rCBF) in Parkinson's disease (PD) were investigated. Because of individual differences in brain volume and the extent of brain atrophy, previous functional imaging studies involved potential methodological difficulties. In this study, using the statistical parametric mapping technique, 99mTechnetium-labeled hexamethylpropyleneamineoxime brain single-photon emission computed tomography images from 18 patients with PD were transformed into standard brain-based stereotaxic coordinate spaces and then compared with such images for 11 control subjects matched for age and extent of brain atrophy. A rCBF decrement in the supplementary motor area (SMA) and such decrement in the dorsolateral prefrontal cortex (DLPFC) were observed in the summarized PD images as compared with controls (p&lt 0.005). In a subgroup in the Hoehn-Yahr III/IV stage (11 cases), the rCBF decrement was demonstrated not only in the SMA, but also in the DLPFC and insular cortex (p&lt 0.001). There was a correlation between the degree of the rCBF decrement in the DLPFC or the insular cortex and the score of the unified Parkinson's disease rating scale (p&lt 0.05), while the rCBF decrement in the SMA showed no relationship with the severity of disease. The function of the SMA is closely associated with the nigro-striatal pathway and its impairment can explain the basic akinetic symptoms in PD, which are responsive to L-DOPA treatment. On the other hand, the DLPFC and insular cortex may play key roles in specific symptoms of impairment at advanced stages, such as impaired working memory, postural instability and autonomic dysfunction. We hypothesize that the impairment of the DLPFC and insular function is correlated with the progression of the disease and is related to DOPA-refractory symptoms, which are major problems in the care of patients with advanced PD. Copyright © 2001 Elsevier Science B.V.

The basis of perceptual assimilation of tool and hand has been considered to be in modification of body schemata, for which integration of multimodal sensory information about our body parts is required. Using positron emission tomography and H2 15O, we aimed to identify brain regions that change their neural activity in association with changes in neural processing of visual and/or somatosensory information when humans use a simple tool. Normal subjects were instructed to manipulate a small graspable object with a pair of tongs or with the fingers of their right or left hand. The only site activated during manipulation with the tool, compared with the fingers, with the right hand was the lateral edge of the right intraparietal sulcus (IPS). During manipulation using the left hand with the tool, compared with using the fingers, an area in the middle part of the left IPS was activated. Areas in the contralateral hemisphere were activated during both the tool-use and the finger-use tasks compared to the control task, but there was no statistically significant difference between the tool-use and the finger-use tasks. Therefore, the results suggest that the ipsilateral posterior parietal cortex was recruited during the tool-use tasks to integrate visuosomatosensory information. © 2001 Academic Press.

The purpose of this study was to investigate functional organization in the human brain involved in the representation of knowledge regarding plants. We measured the brain activity of eight male volunteers during the recognition of visual stimuli representing plants, animals and artifacts, using positron emission tomography. The participants were presented with and were required to name silently two different images each of 15 entities belonging to three ontological categories, and 30 series of four to six digits. Marked increases in regional cerebral blood flow were found in the hippocampus and the parahippocampal areas bilaterally and the right lateral occipital cortex during the silent naming of all three categories, compared with that during the silent reading of digits. The right lateral occipital cortex was specifically activated in association with the naming of plants, and the right fusiform cortex was specifically activated in association with the naming of animals. In addition, the right temporo-occipital cortex was activated only during animals and plants, not artifacts. Our results indicate that there were a few characteristic activations for the different categories, and that entities belonging to the different categories are not necessarily represented in different locations of the brain. Copyright © 2001 Elsevier Science Inc.

In order to investigate the human br ain process of facial recognition, a combined study using (H2O)-O-15-PET and MEG was performed, Six right-handed male volunteers participated in this study. The subjects performed the following three tasks for both PET and MEG measurement: 1) discriminating the location of a small red dot which was randomly overlapped on scrambled face images (Ctrl); 2) discriminating the direction of unfamiliar face images (Al); and 3) discriminating the faces of friends and associates from unfamiliar faces (A2). The regional cerebral blood flow was measured by PET. Statistically significant activation during each task was analyzed using SPM96. Evoked magnetic responses following the presentation of images in each of the three tasks were measured by MEG. The PET results revealed that the Al task activated the bilateral fusiform gyri, in comparison with the Ctrl task. The A2 task further activated the bilateral temporal poles, the bilateral hippocampi, and the anterior and posterior cingulate gyri. The MEG data were able to provide time information to the PET data, showing that the posterior part of the inferior occipito-temporal cortices is activated earlier than the more anterior part. Combination of the two modalities suggested posterior-to-anterior information processing in the ventral pathway.

We measured the regional cerebral blood flow (rCBF) in six healthy volunteers with PET (positron emission tomography) and H2 15O to identify the areas of the human brain involved in sensorimotor learning. The learning task was visually guided reaching with sensorimotor discrepancy caused by optical rotation. PET measurements were performed in the early and late stages of the adaptation to the sensorimotor perturbation. Control measurements were obtained during an eye movement task and a reaching task without optical rotation. The rCBF data of each learning stage were compared to those of both control conditions. During the early stage, rCBF increases were detected in the rostral premotor cortex bilaterally, the posterior part of the left superior parietal lobule (SPL), and the right SPL including the intraparietal sulcus (IPS). During the late stage, rCBF increases were detected in the left caudal premotor area, the left supplementary motor area proper, the left SPL, the right SPL including the IPS, and the right postcentral sulcus extending to the inferior parietal lobule. These results reveal that sensorimotor learning accompanies changes in the recruited cortical areas during different stages of the adaptation, reflecting the different functional roles of each area for different components of adaptation, from learning of new sensorimotor coordination to retention or retrieval of acquired coordination. (C) 2000 Academic Press.

Personality traits are a variance of behavioral patterns among individuals and may reflect a variance of brain activity, but their neurobiological explanation is still a matter of debate. Cloninger proposed three dimensions of personality traits, each of which has strong correlation with activity in a specific central monoaminergic system. Although this theory has been supported by physiological and genetic studies, it is still unclear how these personality parameters are correlated with the activity of the cortical networks which control human behavior. Here we measured the regional cerebral blood flow (rCBF) at rest in 30 normal volunteers who completed the personality inventory of Cloninger. Voxel-by-voxel analysis was employed to identify cortical regions where the rCBF showed significant correlation with any of the three personality parameters. Statistically significant correlation was observed in several paralimbic and neocortical regions and was consistent with the assumed monoaminergic influence on neural activity and the distribution of its projections, in each personality dimension. The results suggest that activity in a variety of cortical regions is associated with human personality traits and lend support to Cloninger's theory concerning central monoaminergic influence on human personality traits. (C) 2000 Academic Press.

Spatial normalization methods, which are indispensable for intersubject analysis in current PET studies, have been improved in many aspects. These methods have not necessarily been evaluated as anatomic normalization methods because PET images are functional images. However, in view of the close relation between brain function and morphology, it is very intriguing how precisely normalized brains coincide with each other. In this report, the anatomic precision of spatial normalization is validated with three different methods. Methods: Four PET centers in Japan participated in this study. In each center, six normal subjects were recruited for both H215O-PET and high-resolution MRI studies. Variations in the location of the anterior commissure (AC) and size and contours of the brain and the courses of major sulci were measured in spatially normalized MR images for each method. Spatial normalization was performed as follows. (a) Linear: The AC-posterior commissure and midsagittal plane were identified on MRI and the size of the brain was adjusted to the Talairach space in each axis using linear parameters. (b) Human brain atlas (HBA): Atlas structures were manually adjusted to MRI to determine linear and nonlinear transformation parameters and then MRI was transformed with the inverse of these parameters. (c) Statistical parametric mapping (SPM) 95: PET images were transformed into the template PET image with linear and nonlinear parameters in a least-squares manner. Then, coregistered MR images were transformed with the same parameters used for the PET transformation. Results: The AC was well registered in all methods. The size of the brain normalized with SPM95 varied to a greater extent than with other approaches. Larger variance in contours was observed with the linear method. Only SPM95 showed significant superiority to the linear method when the courses of major sulci were compared. Conclusion: The results of this study indicate that SPM95 is as effective a spatial normalization as HBA, although it does not use anatomic images. Large variance in structures other than the AC and size of the brain in the linear method suggests the necessity of nonlinear transformations for effective spatial normalization. Operator dependency of HBA also must be considered.

We measured regional cerebral blood flow (rCBF) using positron emission tomography (PET) to determine which brain regions are involved in the assessment of facial emotion. We asked right-handed normal subjects to assess the signalers' emotional state based on facial gestures and to assess the facial attractiveness, as well as to discriminate the background color of the facial stimuli, and compared the activity produced by each condition. The right inferior frontal cortex showed significant activation during the assessment of facial emotion in comparison with the other two tests. The activated area was located within a triangular area of the inferior frontal cortex in the right cerebral hemisphere. These results, together with those of previous imaging and clinical studies, suggest that the right inferior frontal cortex processes emotional communicative signals that could be visual or auditory and that there is a hemispheric asymmetry in the inferior frontal cortex in relation to the processing of emotional communicative signals.

FRONTAL cortical damage can lead to changes in affective aspects of personality. However, the difficulty of dissociating such abnormalities from cognitive disorders has overshadowed most previous findings. Regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) while normal subjects were assessing facial attractiveness. Two left frontal regions showed a significant increase in rCBF while assessing facial attractiveness. The increased rCBF in the left anterior frontal cortex correlated with the overall percentage of assessments of a face as unattractive, while that in the left fronto-temporal junction correlated with the percentage of assessments of a face as attractive. These findings provide direct evidence that the left frontal regions are engaged in the assessment of facial attractiveness.

We have created images of z value, error, and variation components for a PET activation study using various ANOVA designs and anatomical standardization methods. Data were acquired in four PET centers. In each center, CBF was measured on six normal male subjects under resting and covert verb generation, three times for each. The images were anatomically standardized with LINEAR transformation, SPM (Ver. 95), HBA (Karolinska/Tohoku), or MICHIGAN (Minoshima). ANOVA was performed pixel by pixel to compute t (and z) for the task main effect (Verb vs Rest) in four different designs: (i) two way (subject and task) (2W), (ii) two-way with interaction (2WI), (iii) subject considered a random factor (2WI-MX), and (iv) three-way (subject, task, and replication) (3W). A large area extending from the Broca to the left premotor cortex was activated. The localization of the highest peak depended both on the anatomical standardization and on the ANOVA design, the variation ranging 3-4 cm. Smoothing reduced the variation while erasing possible subfoci. The z images of 2W, 2WI, and 3W looked alike, whereas 2WI-MX presented lower peak z values. SPM tended to present higher z values than the other methods. The error was high in the gray and low in the white matter. The root mean square for the subject effect was high on the border of gray matter especially in LINEAR and HBA, revealing intersubject mismatch in the gray matter distribution. The root mean square for the subject-by-task interaction effect revealed individual variation in activation.

This study was conducted to determine where in the human brain visual feedback of hand movements is processed to allow accurate pointing. Regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) and H2 15O in nine normal volunteers while performing one control and two reaching tasks. In all tasks, visual stimuli were presented on a head mounted display (HMD). A target board was placed in front of the subjects bearing six red light-emitting diodes (LEDs) aligned on a circle with a green LED at its center. The center green LED and one of the six red LEDs, randomly selected, were repeatedly switched on and off, alternatively. In the control task, subjects were instructed to gaze at the lit LED. In the two reaching tasks, the reaching with visual feedback (RwithF) task and the reaching without visual feedback (RwithoutF) task, they had to point to the lit red LED with their fight index fingers. In the RwithF task, their right hands were visible on the HMD before touching the target, whereas in the RwithoutF task, they were not visible. For each subject, subtraction images of each reaching task minus the control and the RwithF task minus the RwithoutF task were calculated after transformation of PET images into the standard brain shape with an adjustable computerized brain atlas. These subtraction rCBF images were then averaged among the subjects, and significant changes of rCBF were identified. Significant increases in rCBF not only in the RwithF task minus control image but also in the RwithF task minus the RwithoutF task image were observed in the supramarginal cortex, the premotor cortex and the posterior cingulate cortex of the left hemisphere, the caudate nucleus and the thalamus of the right hemisphere, and the right cerebellum and vermis. These results indicate that the supramarginal cortex, the premotor cortex, and the posterior cingulate cortex of the left hemisphere and the cerebellum are involved in integrating visual feedback of hand movements and execution of accurate pointing.

The purpose of this study was to identify the brain regions activated in relation to oculomotor sequence learning. Nine healthy subjects participated in the study, which consisted of three positron emission tomography scans. In the initial learning task, subjects were instructed to track a sequence of seven successive positions of visual targets and to memorize the order of the targets as well as their spatial locations. In the saccade task, subjects were instructed to track visual targets presented at random locations. In the control task, subjects were instructed to gaze at a fixation point. Fields showing significant regional cerebral blood flow change were determined from task-minus-control subtraction images. We determined that fields in the pre-supplementary motor area (pre-SMA), the intraparietal cortex, and the prefrontal cortex were activated not only in the learning-minus-control images but also in the learning-minus-saccade images. Although prefrontal and parietal activations were bilateral, pre-SMA activation was confined to the left hemisphere. The results indicate that these fields function as a part of the neural network involved in the learning of sequential saccadic eye movements.

REGIONAL cerebral blood flow (rCBF) was measured in six subjects to study changes of activity in the parietal cortex during learning of a visually guided pointing task with a discrepancy of visuomotor coordination and to determine whether reorganization affects the parietal activity after learning. During the early stage of learning, the right posterior parietal cortex showed a significant increase in rCBF. During the late stage, on the other hand, significant activation was noted in the postcentral gyrus of the right hemisphere. These results support a role for the posterior parietal cortex in remapping visuomotor coordinates and suggest the involvement of the human postcentral gyrus in retaining sensorimotor coordinates, considered to relate to the self image of the hand.

Regional cerebral blood flow was measured in six healthy volunteers by positron emission tomography during identification of speaker and emotion from spoken words. The speaker identification task activated several audio-visual multimodal areas, particularly the temporal poles in both hemispheres, which may be involved in connecting vocal attributes with the visual representations of speakers. The emotion identification task activated regions in the cerebellum and the frontal lobe, suggesting a functional relationship between those regions involved in emotion. The results suggest that different anatomical structures contribute to the vocal identification of speaker and emotion.