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東北メディカル・メガバンク機構

研究者リスト >> 大槻 晃史
 

大槻 晃史

 
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研究者氏名大槻 晃史
 
オオツキ アキヒト
URLhttp://www.dmbc.med.tohoku.ac.jp/official/
所属東北大学
部署東北メディカル・メガバンク機構 ゲノム解析部門
職名助教
学位博士(医学)(東北大学)
J-Global ID201701015313608920

研究キーワード

 
分子生物学 ,医化学

研究分野

 
  • ライフサイエンス / 医化学 / 

論文

 
 
Mika Sakurai-Yageta   Kazuki Kumada   Chinatsu Gocho   Satoshi Makino   Akira Uruno   Shu Tadaka   Ikuko N Motoike   Masae Kimura   Shin Ito   Akihito Otsuki   Akira Narita   Hisaaki Kudo   Yuichi Aoki   Inaho Danjoh   Jun Yasuda   Hiroshi Kawame   Naoko Minegishi   Seizo Koshiba   Nobuo Fuse   Gen Tamiya   Masayuki Yamamoto   Kengo Kinoshita   
The Journal of Biochemistry      2021年5月
<title>Abstract</title>
Ethnic-specific SNP arrays are becoming more important to increase the power of genome-wide association studies in diverse population. In the Tohoku Medical Megabank Project, we have been developing a series of Japonica Ar...
 
Akihito Otsuki   Yasunobu Okamura   Yuichi Aoki   Noriko Ishida   Kazuki Kumada   Naoko Minegishi   Fumiki Katsuoka   Kengo Kinoshita   Masayuki Yamamoto   
Molecular and cellular biology   41(2)    2021年1月
Our body responds to environmental stress by changing the expression levels of a series of cytoprotective enzymes/proteins through multilayered regulatory mechanisms, including the KEAP1-NRF2 system. While NRF2 upregulates the expression of many c...
 
Jun Takayama   Shu Tadaka   Kenji Yano   Fumiki Katsuoka   Chinatsu Gocho   Takamitsu Funayama   Satoshi Makino   Yasunobu Okamura   Atsuo Kikuchi   Sachiyo Sugimoto   Junko Kawashima   Akihito Otsuki   Mika Sakurai-Yageta   Jun Yasuda   Shigeo Kure   Kengo Kinoshita   Masayuki Yamamoto   Gen Tamiya   
Nature communications   12(1) 226-226   2021年1月   [査読有り]
The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries....
 
Shu Tadaka   Eiji Hishinuma   Shohei Komaki   Ikuko N Motoike   Junko Kawashima   Daisuke Saigusa   Jin Inoue   Jun Takayama   Yasunobu Okamura   Yuichi Aoki   Matsuyuki Shirota   Akihito Otsuki   Fumiki Katsuoka   Atsushi Shimizu   Gen Tamiya   Seizo Koshiba   Makoto Sasaki   Masayuki Yamamoto   Kengo Kinoshita   
Nucleic acids research   49(D1) D536-D544   2021年1月
In the Tohoku Medical Megabank project, genome and omics analyses of participants in two cohort studies were performed. A part of the data is available at the Japanese Multi Omics Reference Panel (jMorp; https://jmorp.megabank.tohoku.ac.jp) as a w...
 
Noriko Ishida   Yuichi Aoki   Fumiki Katsuoka   Ichiko Nishijima   Takahiro Nobukuni   Hayato Anzawa   Li Bin   Miyuki Tsuda   Kazuki Kumada   Hisaaki Kudo   Takahiro Terakawa   Akihito Otsuki   Kengo Kinoshita   Riu Yamashita   Naoko Minegishi   Masayuki Yamamoto   
Free radical biology & medicine   161 71-83   2020年12月   [査読有り]
Human lymphoblastoid cell lines (LCLs) are valuable for the functional analyses of diseases. We have established more than 4200 LCLs as one of the resources of an integrated biobank. While oxidative and inflammatory stresses play critical roles in...

MISC

 
 
Mikiko Suzuki   Akihito Otsuki   Nadine Keleku-Lukwete   Masayuki Yamamoto   
Current Opinion in Toxicology   1 29-36   2016年   
The Keap1–Nrf2 pathway is a cellular defense system against oxidative and xenobiotic stresses derived from reactive oxygen species (ROS) and electrophiles, respectively. Nrf2 is a key transcription factor that activates a set of cytoprotective gen...
 
森口尚   于磊   大槻晃史   山本雅之   エンゲル ジェームスダグラス   
日本生化学会大会(Web)   89th ROMBUNNO.3P‐218 (WEB ONLY)   2016年   
 
Masanobu Morita   Takafumi Suzuki   Hiromi Suda   Akihito Otsuki   Mikiko Suzuki   Ritsuko Shimizu   Masayuki Yamamoto   
TRANSGENIC RESEARCH   23(5) 874-874   2014年10月   

共同研究・競争的資金等の研究課題

 
 
sMaf転写因子を中心とした遺伝子発現制御ネットワークの解明
日本学術振興会: 科学研究費助成事業 若手研究
大槻 晃史 
研究期間: 2019年4月 - 2021年3月