顔写真

コグレ マナ
小暮 真奈
Mana Kogure
所属
東北メディカル・メガバンク機構 予防医学・疫学部門
職名
講師
学位
  • 博士(医学)(東北大学)

  • 修士(医科学)(東北大学)

委員歴 2

  • 一般社団法人 日本疫学会 代議員

    2021年6月 ~ 継続中

  • 一般社団法人日本循環器病予防学会 評議員

    2017年6月 ~ 継続中

所属学協会 5

  • 日本栄養改善学会

  • 日本高血圧学会

  • 日本循環器病予防学会

  • 日本公衆衛生学会

  • 日本疫学会

研究キーワード 3

  • 公衆衛生

  • 疫学

  • 栄養疫学

研究分野 2

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない /

  • ライフサイエンス / 栄養学、健康科学 /

受賞 3

  1. 第5回 日本オープンイノベーション大賞 選考委員会特別賞

    2023年2月 内閣府

  2. 第31回血圧管理研究会日野原重明賞

    2019年11月 血圧管理研究会

  3. 優秀演題賞

    2017年6月 宮城県公衆衛生学会学術総会

論文 82

  1. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. 国際誌

    Yoshiaki Noji, Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Tomohiro Nakamura, Naho Tsuchiya, Haruki Momma, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Ryoichi Nagatomi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    BMC public health 24 (1) 714-714 2024年3月5日

    DOI: 10.1186/s12889-024-18244-z  

    詳細を見る 詳細を閉じる

    BACKGROUND: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. METHODS: We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. RESULTS: Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. CONCLUSIONS: Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.

  2. Dietary habits and plasma lipid concentrations in a general Japanese population. 国際誌

    Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

    Metabolomics : Official journal of the Metabolomic Society 20 (2) 34-34 2024年3月5日

    DOI: 10.1007/s11306-024-02087-1  

    詳細を見る 詳細を閉じる

    INTRODUCTION: Accumulating data on the associations between food consumption and lipid composition in the body is essential for understanding the effects of dietary habits on health. OBJECTIVES: As part of omics research in the Tohoku Medical Megabank Community-Based Cohort Study, this study sought to reveal the dietary impact on plasma lipid concentration in a Japanese population. METHODS: We conducted a correlation analysis of food consumption and plasma lipid concentrations measured using mass spectrometry, for 4032 participants in Miyagi Prefecture, Japan. RESULTS: Our analysis revealed 83 marked correlations between six food categories and the concentrations of plasma lipids in nine subclasses. Previously reported associations, including those between seafood consumption and omega-3 fatty acids, were validated, while those between dairy product consumption and odd-carbon-number fatty acids (odd-FAs) were validated for the first time in an Asian population. Further analysis suggested that dairy product consumption is associated with odd-FAs via sphingomyelin (SM), which suggests that SM is a carrier of odd-FAs. These results are important for understanding odd-FA metabolism with regards to dairy product consumption. CONCLUSION: This study provides insight into the dietary impact on plasma lipid concentration in a Japanese population.

  3. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study

    Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N. Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Atsushi Shimizu, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension Research 2024年2月29日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41440-024-01582-1  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23–45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.

  4. Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

    Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology 2024年2月24日

    DOI: 10.2188/jea.JE20230241  

    詳細を見る 詳細を閉じる

    BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.

  5. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 2024年2月6日

    DOI: 10.5551/jat.64535  

    詳細を見る 詳細を閉じる

    AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.

  6. Effects of greenery at different heights in neighbourhood streetscapes on leisure walking: a cross-sectional study using machine learning of streetscape images in Sendai City, Japan. 国際誌 査読有り

    Shusuke Sakamoto, Mana Kogure, Tomoya Hanibuchi, Naoki Nakaya, Atsushi Hozawa, Tomoki Nakaya

    International Journal of Health Geographics 22 (1) 29-29 2023年11月8日

    DOI: 10.1186/s12942-023-00351-6  

    詳細を見る 詳細を閉じる

    BACKGROUND: It has been pointed out that eye-level greenery streetscape promotes leisure walking which is known to be a health -positive physical activity. Most previous studies have focused on the total amount of greenery in the eye-level streetscape to investigate its association with walking behaviour. While it is acknowledged that taller trees contribute to greener environments, providing enhanced physical and psychological comfort compared to lawns and shrubs, the examination of streetscape metrics specifically focused on greenery height remains largely unexplored. Therefore, this study examined the relationship between objective indicators of street greenery categorized by height from a pedestrian viewpoint and leisure walking time. METHODS: We created streetscape indices of street greenery using Google Street View Images at 50-m intervals in an urban area in Sendai City, Japan. The indices were classified into four ranges according to the latitude of the virtual hemisphere centred on the viewer. We then investigated their relationship to self-reported leisure walking. RESULTS: Positive associations were identified between the street greenery in higher positions and leisure walking time, while there was no significant association between the greenery in lower positions. CONCLUSION: The findings indicated that streets with rich greenery in high positions may promote residents' leisure walking, indicating that greenery in higher positions contributes to thermally comfortable and aesthetic streetscapes, thus promoting leisure walking. Increasing the amount of greenery in higher positions may encourage residents to increase the time spent leisure walking.

  7. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. 国際誌

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 2023年10月31日

    DOI: 10.1038/s41440-023-01484-8  

    詳細を見る 詳細を閉じる

    Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.

  8. The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study

    Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Hideaki Hashimoto, Tomohiro Nakamura, Kotaro Nochioka, Taku Obara, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Akira Uruno, Eiichi N. Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension Research 2023年10月13日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41440-023-01454-0  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    Abstract This study aimed to examine whether risk of withdrawal from HTTx was higher in coastal areas that were severely damaged by tsunami than in inland areas. We conducted a cross-sectional study of 9218 participants aged ≥20 years in Miyagi, Japan. The odds ratios (ORs) and confidence interval (CI) for withdrawal from HTTx in coastal and inland groups were compared using multivariate logistic regression analysis, adjusting for potential confounders. In total, 194 of 5860 and 146 of 3358 participants in the inland and coastal groups, respectively, withdrew from HTTx treatment. OR (95%CI) of withdrawal from HTTx in the coastal group was 1.46 (1.14–1.86) compared to the inland group. According to housing damage, ORs (95% CI) in the no damage, partially destroyed, and more than half destroyed coastal groups compared with the no damage inland group were 1.62 (1.04–2.50), 1.69 (1.17–2.45), and 1.08 (0.71–1.65), respectively. In conclusion, the risk of HTTx withdrawal for participants whose homes in coastal areas were relatively less damaged was significantly higher compared with those in inland areas, while the risk of HTTx withdrawal for participants whose homes were more than half destroyed was not. Post-disaster administrative support for disaster victims is considered vital for continuation of their treatment.

  9. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Journal of atherosclerosis and thrombosis 2023年10月6日

    DOI: 10.5551/jat.64425  

    詳細を見る 詳細を閉じる

    AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.

  10. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. 国際誌

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Journal of Alzheimer's disease : JAD 2023年9月11日

    DOI: 10.3233/JAD-230318  

    詳細を見る 詳細を閉じる

    BACKGROUND: Olfactory function decline has recently been reported to be associated with a risk of cognitive impairment. Few population-based studies have included younger adults when examining the association between olfactory test data with multiple odor intensities and suspected cognitive impairment. OBJECTIVE: We investigated the association between high-resolution olfactory test data with fewer odors and suspected cognitive impairments. We also examined the differences between older and younger adults in this association. METHODS: The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered to 1,450 participants, with three odor-intensity-level olfactometry using six different odors. Logistic regressions to discriminate suspected cognitive impairment were conducted to examine the association, adjusted for age, sex, education duration, and smoking history. Data were collected from the Program by Tohoku University Tohoku Medical Megabank Organization, with an additional olfactory test conducted between 2019 and 2021. RESULTS: We generally observed that the lower the limit of distinguishable odor intensity was, the higher the MoCA-J score was. The combination of spearmint and stuffy socks contributed most to the distinction between suspected and unsuspected cognitive impairment. Furthermore, the association was significant in women aged 60-74 years (adjusted odds ratio 0.881, 95% confidence interval [0.790, 0.983], p = 0.024). CONCLUSIONS: The results indicate an association between the limit of distinguishable odor intensity and cognitive function. The olfactory test with multiple odor intensity levels using fewer odors may be applicable for the early detection of mild cognitive impairment, especially in older women aged 60-74 years.

  11. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 45回 261-261 2023年9月

    出版者・発行元:(NPO)日本高血圧学会

  12. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 45回 358-358 2023年9月

    出版者・発行元:(NPO)日本高血圧学会

  13. Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study. 国際誌

    Takashi Ohe, Mitsuhiro Yamada, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Nobuo Fuse, Shinichi Kuriyama, Ayumi Mitsune, Ayumi Suzuki, Shuichiro Matsumoto, Tetsuya Hatakeyama, Chikashi Iwasaki, Manami Suzuki, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Akira Koarai, Tsutomu Tamada, Masayuki Yamamoto, Masakazu Ichinose, Hisatoshi Sugiura

    Respiratory investigation 61 (5) 588-600 2023年7月8日

    DOI: 10.1016/j.resinv.2023.06.004  

    詳細を見る 詳細を閉じる

    BACKGROUND: Birth weight, as a measure of intrauterine growth, is commonly used in epidemiological studies and is reported to be associated with adult lung function. However, findings regarding this association in previous studies have been inconsistent. Furthermore, no studies have reported associations stratified by age or smoking status, or adjusted for eosinophil count or other parameters related to type 2 airway inflammation. METHODS: This cross-sectional study included 2632 men and 7237 women aged ≥20 years living in Miyagi Prefecture, Japan. Lung function was assessed based on spirometry. Birth weight data were obtained through a questionnaire survey. Analysis of covariance was used to evaluate the associations between birth weight and lung function, adjusting for potential confounders. Stratified analyses by age and smoking status were also conducted, together with a sub-analysis for low birth-weight participants. RESULTS: Birth weight was positively associated with forced expiratory volume in 1 s (FEV1) for both sexes and with vital capacity in women, after adjusting for height, age, smoking status, and parameters related to type 2 airway inflammation. The stratified analysis for smoking status revealed associations in never-smokers and ex-smokers. When stratified by age, the associations were confirmed in middle-aged participants. The effect of smoking status on the FEV1 of low birth-weight participants was not significant. CONCLUSIONS: Our analysis of a large, Japanese adult population showed that birth weight was independently and positively associated with adult lung function, even after adjustment for age, height, smoking status, and parameters related to type 2 airway inflammation.

  14. Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Taku Obara, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Junichi Sugawara, Eiichi N Kodama, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 2023年7月5日

    DOI: 10.5551/jat.64151  

    詳細を見る 詳細を閉じる

    AIM: People with high normal blood pressure (BP) have a higher risk of cardiovascular events than those with normal BP; therefore, progression to hypertension (HT) should be prevented. We aimed to assess the HT risk using central BP and carotid intima media thickness (CIMT) in people with high normal BP. METHODS: This prospective cohort study used the Tohoku Medical Megabank Community-Based Project Cohort Study (conducted from 2013 in Miyagi Prefecture in Japan). The participants had a high normal BP, defined as a systolic BP of 120-139 mmHg and diastolic BP <90 mmHg using brachial BP measurement during the baseline survey. The outcome was new-onset HT during the secondary survey, conducted four years after the baseline survey. RESULTS: Overall, 4,021 participants with high normal BP during the baseline survey, with an average age of 58.7 years, were included; 1,030 (26%) were diagnosed with new-onset HT during the secondary survey, 3.5± 0.7 years after the baseline survey. The multivariable odds ratio (95% confidence interval) for HT in the highest versus lowest quartile of central BP was 1.7 (1.2-2.4, p=0.0030), and that of CIMT was 1.8 (1.4-2.4, p<0.001). Subgroup analysis according to age (<60 and ≥ 60 years) and sex revealed that the central BP was influential in groups with younger age and female individuals; CIMT was influential in all groups. CONCLUSIONS: Higher central BP and thicker CIMT at the baseline were correlated with new-onset HT in individuals with high normal BP, independent of brachial systolic BP and other cardiovascular risk factors.

  15. Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power. 国際誌

    Nanako Shiokawa, Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara, Shin-Ichi Izumi

    Journal of clinical medicine 12 (9) 2023年5月4日

    DOI: 10.3390/jcm12093272  

    詳細を見る 詳細を閉じる

    Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90-8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54-7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings.

  16. 高齢者における尿Na/K比の血圧への影響は非高齢者より大きい

    平田 匠, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 丹野 高三, 寳澤 篤

    日本老年医学会雑誌 60 (Suppl.) 178-178 2023年5月

    出版者・発行元:(一社)日本老年医学会

    ISSN:0300-9173

  17. 抑うつ症状と家庭高血圧発症リスクの関連 東北メディカル・メガバンク計画地域住民コホート調査

    時岡 紗由理, 中谷 直樹, 中谷 久美, 小暮 真奈, 千葉 一平, 畑中 里衣子, 菅野 郁美, 小原 拓, 栗山 進一, 寳澤 篤

    日本循環器病予防学会誌 58 (2) 146-146 2023年5月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  18. White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease. 国際誌

    Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Kimihiko Kaneko, Toshiyuki Takahashi, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

    Scientific reports 13 (1) 6481-6481 2023年4月20日

    DOI: 10.1038/s41598-023-33827-3  

    詳細を見る 詳細を閉じる

    White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p < 0.0001), monocyte count (p = 0.0191), MLR (p = 0.0320), and NLR (p = 0.0002) than those of MOGAD-matched volunteers (n = 130). The three demyelinating diseases showed similar levels of the total and differential WBC counts; however, MOGAD and MS showed different structures in the hierarchical clustering and distributions on a two-dimensional canonical plot using differential WBC counts from the other three groups. WBC count profiles were similar in patients with MOGAD and MS but differed from profiles in matched volunteers or patients with AQP4-NMOSD.

  19. Combined fat mass and fat-free mass indices and lung function among Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of epidemiology 2023年4月8日

    DOI: 10.2188/jea.JE20220355  

    詳細を見る 詳細を閉じる

    BACKGROUND: Although fat mass index (FMI) and fat-free mass index (FFMI) affect lung function, FMI and FFMI are not independent of each other since FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. We aimed to examine the association of combined FMI and FFMI with lung function. METHODS: In this cross-sectional study, lung function was evaluated using forced expiratory volume at 1 s and forced vital capacity was measured using spirometry. Both FMI and FFMI were classified into sex-specific quartiles (16 groups). Analysis of covariance was used to assess the associations of combined FMI and FFMI with lung function. The trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1-4 (lowest-highest), and entering the number as a continuous term in the regression model. RESULTS: This study included 3,736 men and 8,821 women aged ≥20 years living in Miyagi Prefecture, Japan. The mean FEV1 (standard deviation) was 3.0 (0.7) L for men and 2.3 (0.5) L for women. The mean FVC was 3.8 (0.7) L for men and 2.8 (0.5) L for women. The FMI was inversely associated with lung function among all FFMI subgroups in both sexes. Conversely, FFMI was positively associated with lung function in all FMI subgroups in both sexes. CONCLUSIONS: Higher FMI was associated with lower lung function independent of FFMI; higher FFMI was associated with higher lung function independent of FMI. Reducing FMI and maintaining FFMI might be important for respiratory health.

  20. Association between the extent of house collapse and urine sodium-to-potassium ratio of victims affected by the 2011 Great East Japan Earthquake and Tsunami: a cross-sectional study

    Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Koichi Asahi, Fumitaka Tanaka, Shinichi Omama, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Atsushi Hozawa, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki

    Hypertension Research 2023年2月17日

    出版者・発行元:Springer Science and Business Media LLC

    DOI: 10.1038/s41440-023-01190-5  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    Abstract People who experience natural disasters have a high risk of developing cardiovascular diseases. We investigated the association between the extent of house collapse and urine sodium-to-potassium (UNa/K) ratio of 2011 Great East Japan Earthquake victims. We used the baseline survey data of the Tohoku Medical Megabank Project Community-Based Cohort Study of 29 542 individuals (aged 20–74 years) residing in the affected areas. The UNa/K ratio was calculated using spot urinary electrolyte values. Analysis of covariance was used to calculate the multivariate-adjusted geometric means of the UNa/K ratio in the following groups stratified according to the self-reported extent of house collapse: total collapse (TC), half collapse (HC), partial collapse (PC), and no damage (ND). Multivariable-adjusted odds ratios (ORs) for a high UNa/K ratio were calculated using logistic regression. The TC, HC, PC, and ND groups comprised 5 359 (18.1%), 3 576 (12.1%), 7 331 (24.8%), and 13 276 (44.9%) participants, respectively. The TC (3.33; 95% confidence interval [CI], 3.28–3.38), HC (3.37; 3.30–3.43), and PC (3.32; 3.28–3.37) groups had significantly higher multivariate-adjusted geometric means of the UNa/K ratio than the ND (3.24; 3.21–3.27) group. The multivariable-adjusted ORs (95% CIs) for a high UNa/K ratio in the TC, HC, and PC groups vs. the ND group were 1.07 (0.99–1.15), 1.20 (1.11–1.31), and 1.20 (1.12–1.28), respectively. Similar associations between house collapse and UNa/K ratio were observed for both sexes. We report that victims of a natural disaster tend to have a diet with high sodium-to-potassium ratio.

  21. Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 2023年2月11日

    DOI: 10.5551/jat.64039  

    詳細を見る 詳細を閉じる

    AIM: We examined the association between the carotid intima medica thickness (cIMT) and risk factors for atherosclerosis based on the Japan Atherosclerosis Society 2022 Atherosclerosis Prevention Guideline. METHODS: Using data from the Tohoku Medical Megabank Community-based Cohort Study, we performed a cross-sectional study that enrolled 13,366 participants (age ≥ 20 years) with an analysis of covariance to assess associations between cIMT and risk factors for atherosclerosis. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. Analysis was conducted in the model adjusted for age, sex, smoking status, drinking status, body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), high-density lipoprotein-cholesterol (HDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C), and height. RESULTS: In this study cohort, the average age and cIMT were 57.3 (13.8) years and 0.61 (0.13) mm, respectively, which included 3,988 males (29.8%). Males had a higher cIMT than did the females. Age, height, BMI, SBP, HbA1c, and non-HDL-C were positively associated with cIMT. HDL-C was inversely associated with cIMT. Compared with never drinkers, current drinkers (≥ 46.0 g/day) had a significantly decreased cIMT. CONCLUSIONS: The cIMT was associated with atherosclerosis risk factors including age, sex, BMI, SBP, HbA1c, non-HDL-C, and HDL-C, and adequate control of risks in high-risk individuals might be required to prevent atherosclerotic cardiovascular diseases.

  22. 地域在住高齢者の自己報告による視覚障害と要介護発生との関連 鶴ヶ谷プロジェクト

    小幡 紘輝, 鈴鴨 よしみ, 宮武 ミドリ, 永富 良一, 小暮 真奈, 中谷 直樹, 寳澤 篤, 出江 紳一

    Journal of Epidemiology 33 (Suppl.1) 149-149 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  23. 診察室非高血圧者における抑うつ気分と仮面高血圧の関連性の検討

    時岡 紗由理, 中谷 直樹, 千葉 一平, 中谷 久美, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 小原 拓, 栗山 進一, 辻 一郎

    Journal of Epidemiology 33 (Suppl.1) 141-141 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  24. BMI・飲酒・尿Na/K比と高血圧の関連における両親の高血圧既往の影響

    平田 匠, 小暮 真奈, 畑中 里衣子, 千葉 一平, 中谷 久美, 菅野 郁美, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 155-155 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  25. 脂肪量指数と除脂肪量指数の組み合わせと呼吸機能検査指標の関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 155-155 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  26. 糖尿病指標と嗅覚機能の関連

    佐竹 芽久美, 菅野 郁美, 佐藤 守一, 今枝 孝夫, 高梨 昌樹, 早川 和美, 中谷 久美, 千葉 一平, 小暮 真奈, 畑中 里衣子, 斉藤 智, 中村 智洋, 長神 風二, 荻島 創一, 布施 昇男, 麦倉 俊司, 栗山 進一, 中谷 直樹, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 156-156 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  27. 東北メディカル・メガバンク計画地域住民コホート調査(宮城)詳細二次調査の概要

    中谷 久美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 中村 智洋, 小原 拓, 宇留野 晃, 布施 昇男, 辻 一郎, 栗山 進一, 寳澤 篤

    Journal of Epidemiology 33 (Suppl.1) 173-173 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  28. Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. 国際誌

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of hypertension 41 (3) 443-52 2023年1月4日

    DOI: 10.1097/HJH.0000000000003356  

    詳細を見る 詳細を閉じる

    BACKGROUND: Although several studies have shown an inverse association between lung function and hypertension, few studies have examined the association between lung function and hypertension among never-smokers, and no study has investigated the association between lung function and home hypertension. We investigated the associations between lung function and hypertension in a Japanese population. INDIVIDUALS AND METHODS: We conducted a cross-sectional study of 3728 men and 8795 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was assessed using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC), measured by spirometry. Hypertension was defined as a casual blood pressure at least 140/90 mmHg and/or self-reported treatment for hypertension. Home hypertension was defined as morning home blood pressure at least 135/85 mmHg and/or self-reported treatment for hypertension. Multivariate logistic regression models adjusted for potential confounders were used to assess the association between lung function and hypertension. RESULTS: The mean ages (±SD) of men and women were 60.1 (±14.0) years and 56.2 (±13.4) years, respectively, and 1994 (53.5%) men and 2992 (34.0%) women had hypertension. In the multivariable models, FEV1 and FVC were inversely associated with hypertension. Inverse associations between lung function and hypertension were observed even among never-smokers. Furthermore, reduced lung function was associated with higher prevalence of home hypertension in men and women. CONCLUSION: Reduced lung function was associated with higher prevalence of hypertension, independent of smoking status. Assessment of the lung function or blood pressure may be required in individuals with reduced lung function or hypertension.

  29. The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 2022年11月4日

    DOI: 10.5551/jat.63826  

    詳細を見る 詳細を閉じる

    AIM: Impaired lung function is associated with atherosclerotic vascular events. Carotid intima-media thickness (cIMT) is a marker for subclinical atherosclerosis. However, few studies have examined the association between lung function and cIMT among never smokers or individuals stratified by age. We investigated the association between lung function and cIMT in the Japanese population. METHODS: We conducted a cross-sectional study of 3,716 men and 8,765 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was evaluated using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) was measured using spirometry. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between lung function and cIMT and adjusted for potential confounders. A linear trend test was conducted by scoring the categories from 1 (lowest) to 4 (highest) and entering the score as a continuous term in the regression model. RESULTS: After adjusting for potential confounders including passive smoking, lower FEV1 and FVC were associated with higher cIMT in both men and women (P<0.001 for linear trend). This association was confirmed even when we restricted our study to never smokers. Furthermore, even when we stratified by age, an inverse association between lung function and cIMT was confirmed in middle-aged (40-64 years) and elderly participants (65-74 years). CONCLUSIONS: Lower lung function was associated with higher cIMT in the Japanese population independent of age and smoking. Assessment of atherosclerosis or lung function may be required for individuals with lower lung function or atherosclerosis.

  30. これからの循環器病予防研究者育成に何が必要か? 循環器病予防研究者からの提言

    桑原 政成, 佐藤 倫広, 小暮 真奈, 田中 伸弥, 辰巳 友佳子, 矢野 裕一朗, 東條 美奈子, 大久保 孝義

    日本循環器病予防学会誌 57 (3) 214-219 2022年11月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  31. Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan. 国際誌

    Naoki Nakaya, Kumi Nakaya, Naho Tsuchiya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ikumi Kanno, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Shinichi Kuriyama

    BMC public health 22 (1) 1978-1978 2022年10月28日

    DOI: 10.1186/s12889-022-14348-6  

    詳細を見る 詳細を閉じる

    BACKGROUND: Previous observational studies have shown similarities in cardiometabolic risk factors between spouses. It is still possible that this result reflects the age similarity of spouses rather than environmental factors of spouses (e.g. cohabitation effect). To clarify the importance of mate cardiometabolic risk factors for similarity of environmental factors, it is necessary to examine whether they are observed in random male-female pairs while maintaining the age of the spousal pairs. This study aimed to determine whether the similarities found between spousal pairs for cardiometabolic risks were also observed between random male-female pairs. METHODS: This cross-sectional study included 5,391 spouse pairs from Japan; data were obtained from a large biobank study. For pairings, women of the same age were randomly shuffled to create new male-female pairs of the same age as that of the original spouse pairs. Similarities in cardiometabolic risk factors between the random male-female pairs were analysed using Pearson's correlation or age-adjusted logistic regression analyses. RESULTS: The mean ages of the men and women were 63.2 and 60.4 years, respectively. Almost all cardiometabolic risk factors similarities were not noted in cardiometabolic risk factors, including the continuous risk factors (anthropometric traits, blood pressure, glycated haemoglobin level, and lipid traits); lifestyle habits (smoking, drinking, and physical activity); or diseases (hypertension, type 2 diabetes mellitus, and metabolic syndrome) between the random male-female pairs. The age-adjusted correlation coefficients ranged from - 0.007 for body mass index to 0.071 for total cholesterol. The age-adjusted odds ratio (95% confidence interval) for current drinkers was 0.94 (0.81 - 1.09); hypertension, 1.07 (0.93 - 1.23); and type 2 diabetes mellitus, 1.08 (0.77 - 1.50). CONCLUSION: In this study, few similarities in cardiometabolic risk factors were noted among the random male-female pairs. As spouse pairs may share environmental factors, intervention strategies targeting lifestyle habits and preventing lifestyle-related diseases may be effective.

  32. Visualization of estimated prevalence of CES-D positivity accounting for background factors and AIS scores. 国際誌

    Takashi Matsuyama, Akira Narita, Masaki Takanashi, Mana Kogure, Shuichi Sato, Tomohiro Nakamura, Hideo Nakane, Soichi Ogishima, Fuji Nagami, Naoki Nakaya, Kozo Tanno, Takao Imaeda, Atsushi Hozawa

    Scientific reports 12 (1) 17656-17656 2022年10月21日

    DOI: 10.1038/s41598-022-22266-1  

    詳細を見る 詳細を閉じる

    Development of methods for population screening is necessary to improve the efficiency of secondary prevention of diseases. Until now, a common cutoff has been used for all people in the data set. However, if big data for health information can be used to modify individual cutoffs according to background factors, it may avoid wasting medical resources. Here we show that the estimated prevalence of the Center for Epidemiologic Studies Depression Scale positivity can be visualized by a heatmap using background factors from epidemiological big data and scores from the Athens Insomnia Scale. We also show that cutoffs based on the estimated prevalence can be used to decrease the number of people screened without decreasing the number of prevalent cases detected. Since this method can be applied to the screening of different outcomes, we believe our work can contribute to the development of efficient screening methods for various diseases.

  33. 地域在住高齢者の予測努力肺活量と肺炎死の関連および筋力と血清総コレステロール値の影響

    汐川 菜々子, 岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 海老原 覚, 小暮 真奈, 中谷 直樹, 寳澤 篤, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine 59 (秋季特別号) S444-S444 2022年10月

    出版者・発行元:(公社)日本リハビリテーション医学会

    ISSN:1881-3526

    eISSN:1881-8560

  34. 東日本大震災による自宅の被害状況と高血圧治療中断との関連

    畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中村 智洋, 後岡 広太郎, 小原 拓, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 196-196 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  35. 過敏性腸症候群の有病に関連する要因の検討 TMM計画地域住民コホート調査

    中谷 久美, 中谷 直樹, 永家 聖, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 金澤 素, 荻島 創一, 栗山 進一, 辻 一郎, 寳澤 篤, 福土 審

    日本公衆衛生学会総会抄録集 81回 201-201 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  36. 呼吸機能検査指標と高血圧有病との関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 土屋 菜歩, 平田 匠, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 202-202 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  37. 被災後住居形態と肝機能指標に関する横断研究

    相場 繁, 中谷 直樹, 小暮 真奈, 中谷 久美, 畑中 里衣子, 千葉 一平, 菅野 郁美, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 237-237 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  38. 生活習慣病の既往がない者における食事パターンと受診行動および医療費の関連

    五十嵐 有香, 小暮 真奈, 鈴木 寿則, 畑中 里衣子, 中谷 久美, 菅野 郁美, 千葉 一平, 中村 智洋, 荻島 創一, 中谷 直樹, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 246-246 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  39. 健康診査への尿ナトリウム/カリウム比測定導入から見えてきたことと今後の展開

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 大川 亜美, 黒川 悦子, 永吉 翔, 志賀 利一, 清水 友紀子, 牛田 悠介, 上田 宏幸, 中谷 直樹, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 308-308 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  40. 握力および脚伸展力で測定した各筋力と生理学的データの関連

    野路 慶明, 畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中村 智洋, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 431-431 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  41. 呼吸機能検査指標と高血圧有病との関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 土屋 菜歩, 平田 匠, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 202-202 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  42. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌 (71) 28-28 2022年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  43. 尿ナトリウム/カリウム比と脳性ナトリウム利尿ペプチド 大迫研究

    室谷 智子, 佐藤 倫広, 村上 任尚, 中山 晋吾, 廣瀬 卓男, 橋本 英明, 遠山 真弥, 高畠 恭介, 辰巳 友佳子, 井上 隆輔, 坪田 恵[宇津木], 小暮 真奈, 中谷 直樹, 浅山 敬, 野村 恭子, 菊谷 昌浩, 目時 弘仁, 今井 潤, 寳澤 篤, 大久保 孝義

    東北公衆衛生学会誌 (71) 29-30 2022年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  44. Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis. 国際誌

    I Kanno, K Hasegawa, T Nakamura, M Kogure, F Itabashi, A Narita, N Tsuchiya, T Hirata, N Nakaya, J Sugawara, S Kuriyama, I Tsuji, S Kure, A Hozawa

    Public health 208 98-104 2022年7月

    DOI: 10.1016/j.puhe.2022.05.003  

    詳細を見る 詳細を閉じる

    OBJECTIVES: Previous studies have reported the relationship between housing environment and health, although due to cost and effort, it was difficult to conduct housing condition surveys on a large scale. The CASBEE Housing Health Checklist (the Checklist) made it possible to easily evaluate the housing condition from the resident's perspective. This study examined the relationship between housing coldness/warmth evaluation using the Checklist and psychological distress in a large-scale general Japanese population. STUDY DESIGN: A cross-sectional study. METHODS: We analysed data from 29,380 people aged ≥20 years who lived in Miyagi Prefecture, Japan. As an assessment of housing coldness/warmth, we used the Checklist. We classified participants' total scores on the Checklist related to coldness/warmth into quartiles. The Kessler 6 scale was used as an indicator of psychological distress. Multivariable logistic regression models were used to estimate the adjusted odds ratio (OR) and 95% confidence intervals (CIs). Adjusted OR and P-values for linear trends were calculated using the quartiles of the Checklists' score. RESULTS: Among participants in Q1 (i.e., poorer subjective house condition), the percentage of people with psychological distress was high. Compared to the highest quartile, Q1 showed poorer evaluation of housing coldness/warmth, and higher OR for psychological distress. The OR (95% CI) of psychological distress for Q3, Q2, and Q1 compared with Q4 were 1.93 (1.74-2.14), 2.82 (2.55-3.12), and 5.78 (5.25-6.35), respectively. CONCLUSIONS: Housing coldness/warmth evaluation was significantly related to psychological distress. This finding suggests that maintaining a comfortable thermal environment at home could be important for residents' mental health.

  45. Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis 30 (3) 255-273 2022年5月26日

    DOI: 10.5551/jat.63523  

    詳細を見る 詳細を閉じる

    AIM: Although many epidemiological studies have shown that obesity assessed by body mass index is associated with carotid intima-media thickness (cIMT), few studies have evaluated fat-free mass, which is a component of body composition. We investigated the associations between the combined fat mass index (FMI) and fat-free mass index (FFMI) with cIMT. METHODS: We conducted a cross-sectional study of 3,873 men and 9,112 women aged 20 years or older who lived in Miyagi prefecture, Japan. The FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. The indices were classified into sex-specific quartiles and were combined into 16 groups. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between the combined FMI and FFMI with cIMT adjusted for age and smoking status. The linear trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1 (lowest) to 4 (highest), and entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher FMI was not related to higher cIMT in men and women in most FFMI subgroups. Conversely, a higher FFMI was related to higher cIMT in all FMI subgroups (p<0.001 for linear trend). CONCLUSIONS: FMI was not associated with cIMT in most FFMI subgroups. Conversely, FFMI was positively associated with cIMT independently of FMI.

  46. Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study. 国際誌

    Tomoko Muroya, Michihiro Satoh, Takahisa Murakami, Shingo Nakayama, Kei Asayama, Takuo Hirose, Yukako Tatsumi, Ryusuke Inoue, Megumi Tsubota-Utsugi, Azusa Hara, Mana Kogure, Naoki Nakaya, Kyoko Nomura, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Atsushi Hozawa, Takayoshi Ohkubo

    Journal of hypertension 40 (5) 862-869 2022年5月1日

    DOI: 10.1097/HJH.0000000000003087  

    詳細を見る 詳細を閉じる

    OBJECTIVE: No studies have demonstrated the association between urinary sodium-to-potassium (Na/K) ratio and all out-of-office blood pressure (BP) [home morning and evening BP (self-measured at home), and 24-h, daytime, and night-time ambulatory BP] in the same cohort. We aimed to assess, which type of out-of-office BP is more strongly associated with urinary Na/K ratio in the general population. METHODS: This cross-sectional study was conducted in the general population of Ohasama, Japan. Home and ambulatory BP levels were measured, and 24-h urine samples were obtained from 875 participants (men, 25.5%; mean age, 60.1 years). The urinary Na/K ratio in the 24-h urine samples was calculated. RESULTS: The median (interquartile range) urinary Na/K ratio was 4.19 (3.36-5.26). Significant positive trends of home morning, home evening, 24-h, and daytime SBP were observed across quartiles of urinary Na/K ratio (trend P  < 0.041; adjusted mean values between Q1 and Q4 of urinary Na/K ratio: 121.0-125.5 mmHg for home morning, 120.1-123.8mmhg for home evening, 121.6-123.4mmHg for 24-h, 127.5-129.5 mmHg for daytime). Urinary Na/K ratio was not significantly associated with office or night-time SBP and nocturnal BP fall (trend P > 0.13). In the model with both home morning or evening SBP and daytime SBP, only home SBP was significantly associated with urinary Na/K ratio (P < 0.048 for home SBP). CONCLUSION: These findings suggest that urinary Na/K ratio might be more strongly associated with home BP than with 24-h and daytime BP but was not associated with night-time BP.

  47. Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of diabetes investigation 13 (5) 858-867 2022年5月

    DOI: 10.1111/jdi.13729  

    詳細を見る 詳細を閉じる

    AIMS/INTRODUCTION: Fat mass and fat-free mass affect glycated hemoglobin A1c (HbA1c) levels and blood glucose levels, respectively. The aim of the present study was to examine the association between the fat mass index and fat-free mass index with HbA1c. MATERIALS AND METHODS: We carried out a cross-sectional study that included 3,731 men and 9,191 women aged ≥20 years, living in Miyagi Prefecture, Japan, who were not treated for diabetes. The fat mass index and fat-free mass index were calculated as fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into sex-specific quartiles and combined into 16 groups. An analysis of covariance was used to assess associations between the combined fat mass index and fat-free mass index with HbA1c adjusted for potential confounders. The linear trend test was carried out by stratifying the fat mass index and fat-free mass index, entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher fat mass index was related to higher HbA1c levels in men and women in all fat-free mass index subgroups (P < 0.001 for linear trend). When we excluded the participants who had been identified as having diabetes, the fat-free mass index was also related to higher HbA1c levels in most fat mass index subgroups (P < 0.05 for linear trend). CONCLUSIONS: Fat mass index was positively related to HbA1c levels. The fat-free mass index was also related to HbA1c levels when we excluded participants who had been identified as having have diabetes.

  48. White blood cell count profile in patients with physical complaints without known causes. 国際誌

    Tetsuya Akaishi, Tadashi Ishii, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Masashi Aoki, Atsushi Hozawa

    SAGE open medicine 10 20503121221105328-20503121221105328 2022年

    DOI: 10.1177/20503121221105328  

    詳細を見る 詳細を閉じる

    OBJECTIVES: The aim of this study was to search for routine blood test biomarkers in patients with physical symptoms but without a diagnosis after comprehensive routine screening diagnostic examinations. METHODS: A total of 228 adults aged < 65 years who presented with physical complaints without known causes after comprehensive screening diagnostic examinations and 228 age- and sex-matched healthy controls without physical complaints were enrolled. The blood cell count data at the first hospital visit were compared between these groups. RESULTS: Total white blood cell (p = 0.2143), red blood cell (p = 0.8954), and platelet (p = 0.7716) counts did not differ between the groups. The monocyte count (p = 0.0014) and resultant monocyte-to-lymphocyte ratio (p < 0.0001) were higher in the symptomatic group, while the other white blood cell subtypes did not differ significantly between the two groups. In the symptomatic group, patients with a monocyte-to-lymphocyte ratio > 0.25 were likely to have unexplained nonfocal physical symptoms (p < 0.0001). The characteristic findings included fatigability (p < 0.0001), prolonged slight fever (p = 0.0005), and widespread pain (p < 0.0001). The monocyte-to-lymphocyte ratio level was correlated with the proportion of patients with unexplained nonfocal symptoms. CONCLUSION: The blood cell count profile was largely the same between healthy individuals and patients with unexplained physical symptoms. However, patients with unexplained nonfocal physical complaints were likely to show an elevated monocyte-to-lymphocyte ratio, typically > 0.25.

  49. Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study

    Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Kotaro Nochioka, Akira Narita, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Taku Obara, Michihiro Satoh, Hirohito Metoki, Ken Miyagawa, Hiroshi Koshimizu, Sho Nagayoshi, Akira Uruno, Masahiro Kikuya, Kichiya Suzuki, Naoki Nakaya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension Research 2022年

    DOI: 10.1038/s41440-021-00843-7  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) ratio is known to have diurnal and day-to-day variations. Therefore, we investigated the number of days required to yield a better association between the morning uNa/K ratio and home BP (HBP) and determined a morning uNa/K ratio value that can be used as a reference value in participants who are not taking antihypertensive medication. This was a cross-sectional study using data from the Tohoku Medical Megabank Project Cohort Study. A total of 3122 participants borrowed HBP and uNa/K ratio monitors for 10 consecutive days. We assessed the relationship between the morning uNa/K ratio from 1 day to 10 days and home hypertension (HBP ≥ 135/85 mmHg) using multiple logistic regression models. Although a 1-day measurement of the morning uNa/K ratio was positively associated with home hypertension, multiple measurements of the morning uNa/K ratio were strongly related to home hypertension. The average morning uNa/K ratio was relatively stable after 3 days (adjusted odds ratio of home hypertension per unit increase in the uNa/K ratio for more than 3 days: 1.19–1.23). In conclusion, there was no threshold for the uNa/K ratio, and the morning uNa/K ratio was linearly associated with home hypertension. The Na/K ratio 2.0 calculated from the Dietary Reference Intakes for Japanese might be a good indication. Regarding the stability of the association between the morning uNa/K ratio and BP, more than 3 days of measurements is desirable.

  50. The prevalence of current smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer among participants in a community-based cardiometabolic screening program in Miyagi prefecture, Japan: a comparison with nationally representative surveys in other countries. 国際誌

    Yuka Nishimoto, Yoshitaka Tsubono, Mana Kogure, Tomohiro Nakamura, Fumi Itabashi, Naho Tsuchiya, Naoki Nakaya, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Shigeo Kure, Ichiro Tsuji, Atsushi Hozawa

    Cancer medicine 10 (24) 9000-9011 2021年12月

    DOI: 10.1002/cam4.4364  

    詳細を見る 詳細を閉じる

    BACKGROUND: We determined the prevalence of current cigarette smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer in Japan and compared the findings with nationally representative studies in other countries. METHODS: We conducted a cross-sectional study of baseline data from a prospective cohort study. A self-administered questionnaire was surveyed during 2013-2015 with residents aged ≥20 years attending a community-based cardiometabolic screening program in Miyagi prefecture in north-eastern Japan. Subjects with past cancer histories were classified as cancer survivors. Sex-specific, age-standardized prevalence of current smokers, and drinkers were calculated. Age-adjusted prevalence ratios (PRs: the cancer survivors' rate divided by the rate of subjects with no history of cancer) and 95% confidence intervals (CIs) were estimated with log-binomial regressions. RESULTS: 36,786 subjects, including 2760 cancer survivors, responded and provided usable information (58.9% of recruited subjects). For men, the age-standardized prevalence of current smokers and drinkers among survivors was 18.8% and 74.4%, respectively, with an age-adjusted PR (95%CI) of 0.76 (0.66-0.86, p < 0.001) and 0.95 (0.91-0.98, p = 0.002), respectively. For women, the figures were 6.1%, 37.9%, 0.84 (0.67-1.06, p = 0.138) and 0.96 (0.90-1.03, p = 0.313), respectively. The U.S., the U.K, and Australian studies generally showed no substantially lower prevalence of current smokers or drinkers in survivors than in subjects with no history of cancer (PR ≥ 0.75), while Korean studies did (PR < 0.75). CONCLUSIONS: A considerable proportion of Japanese cancer survivors, especially men, remained currently smoking and drinking. Consistent with Western studies, the rates were not substantially lower than those among subjects with no history of cancer.

  51. White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. 国際誌

    Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

    Scientific reports 11 (1) 22357-22357 2021年11月16日

    DOI: 10.1038/s41598-021-01942-8  

    詳細を見る 詳細を閉じる

    Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system; however, its exact mechanism is unknown. This study aimed to elucidate the profile of white blood cells (WBCs) in the acute phase of an MS attack. Sixty-four patients with MS at the time of diagnosis and 2492 age- and sex-adjusted healthy controls (HCs) were enrolled. Data regarding the blood cell counts were compared between the groups. The total WBC (p < 0.0001), monocyte (p < 0.0001), basophil (p = 0.0027), and neutrophil (p < 0.0001) counts were higher in the MS group than in the HC group, whereas the lymphocyte and eosinophil counts did not differ. Adjustments for the smoking status and body mass index yielded the same results. The total and differential WBC counts of the patients with MS did not correlate with the counts of T2 hyperintense brain lesions or the levels of neurological disturbance. In summary, patients with MS showed elevated counts of total WBCs, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.

  52. Impact of type of reconstructed residence on social participation and mental health of population displaced by disasters. 国際誌

    Tomomi Suzuki, Tetsuya Akaishi, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Scientific reports 11 (1) 21465-21465 2021年11月2日

    DOI: 10.1038/s41598-021-00913-3  

    詳細を見る 詳細を閉じる

    After disasters, people are often forced to reconstruct or move to new residences. This study aimed to reveal the association between the types of reconstructed residences and psychosocial or psychiatric conditions among the population. A total of 1071 adult residents in a coastal town, whose houses were destroyed by the tsunami caused by the Great East Japan Earthquake, enrolled in the study five years after the disaster. The type of reconstructed post-disaster residences (reconstructed on the same site/disaster-recovery public condominium/mass-translocation to higher ground/privately moving to remote areas) and the current psychosocial indicators were investigated. The results revealed that individuals living in public condominiums showed significantly worse scores on the Lubben Social Network Scale-6 (p < 0.0001) and the Center for Epidemiologic Studies Depression Scale (p < 0.0001), and slightly worse scores on the Kessler Psychological Distress Scale (p = 0.035) and the Impact of Event Scale-Revised (p = 0.028). Lower psychosocial indicator scores in the public condominium group were more remarkable in younger adults aged < 65 years. Insomnia evaluated using the Athens Insomnia Scale was not different among the four residential types. In summary, residents moving into disaster-recovery public condominiums are likely to have less social interaction, be more depressed, and may need additional interventions.

  53. Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study. 国際誌

    Masato Takase, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Akira Narita, Takumi Hirata, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Clinical and experimental hypertension (New York, N.Y. : 1993) 43 (7) 610-621 2021年10月3日

    DOI: 10.1080/10641963.2021.1925681  

    詳細を見る 詳細を閉じる

    BACKGROUND: A  higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. METHODS: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. RESULTS: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. CONCLUSIONS: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.

  54. Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing. 国際誌

    Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Disaster medicine and public health preparedness 16 (5) 1-9 2021年8月20日

    DOI: 10.1017/dmp.2021.214  

    詳細を見る 詳細を閉じる

    OBJECTIVE: This study aims to evaluate the long-term impact of living in postdisaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held 5 y after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on 5 types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants 5 y after the disaster. CONCLUSIONS: Living in postdisaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities 5 y later.

  55. Coastal exposure and residents' mental health in the affected areas by the 2011 Great East Japan Earthquake and Tsunami. 国際誌

    Ai Tashiro, Mana Kogure, Shohei Nagata, Fumi Itabashi, Naho Tsuchiya, Atsushi Hozawa, Tomoki Nakaya

    Scientific reports 11 (1) 16751-16751 2021年8月18日

    DOI: 10.1038/s41598-021-96168-z  

    詳細を見る 詳細を閉じる

    No previous study has ever explored the association between coastal exposure and the mental health of residents in a post-disaster context. Therefore, we aimed to confirm whether there was an association between sea visibility and coastal proximity and the mental health of coastal residents a devastating tsunami. We targeted 15 coastal municipalities located in the Miyagi Prefecture, and obtained data from a community-based cohort study. The baseline survey was initiated 2 years after the 2011 Great East Japan Earthquake and Tsunami and the secondary survey was initiated 6 years after the disaster. We applied multilevel mixed-effects models to the longitudinal data. Our outcome measure was the Kessler Psychological Distress Scale (K6) score. We assessed the data collected from 2,327 respondents on both surveys as of April 2018 for this ongoing cohort study. We found that neither sea visibility nor coastal proximity was significantly associated with the recovery of mental health after the disaster. However, we found a distinctive trend of mental health recovery in people who lived alone with a sea view, indicating that visibility of the sea had a negative effect on their mental health immediately after the GEJET, but that the negative effect was subsequently eliminated.

  56. Five-year Psychosocial Impact of Living in Post-Disaster Prefabricated Temporary Housing. 国際誌

    Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Disaster medicine and public health preparedness 1-31 2021年6月23日

    DOI: 10.1017/dmp.2021.212  

    詳細を見る 詳細を閉じる

    OBJECTIVE: This study aims to evaluate the long-term impact of living in post-disaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held five years after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on five types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants five years after the disaster. CONCLUSIONS: Living in post-disaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities five years later.

  57. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. 国際誌 査読有り

    Takumi Hirata, Mana Kogure, Naho Tsuchiya, Ken Miyagawa, Akira Narita, Kotaro Nochioka, Akira Uruno, Taku Obara, Tomohiro Nakamura, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 44 (7) 858-865 2021年2月15日

    DOI: 10.1038/s41440-021-00628-y  

    詳細を見る 詳細を閉じる

    Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese population. We conducted a cross-sectional study including 1384 participants (393 men and 991 women) to estimate the odds ratio (OR) and 95% confidence interval (CI) for the presence of any of the conventional risk factors using multivariable logistic regression analyses. The models were adjusted for sex, age, smoking status, and log-transformed average daily steps. We also estimated the OR and 95% CI for the presence of any of the overall risk factors. Furthermore, we calculated the PAF due to these risk factors. The results showed that the prevalence of home hypertension was 39.0% (540/1384). The presence of any of the conventional risk factors, as well as any of the overall risk factors, was significantly associated with an increased prevalence of hypertension (OR 2.80, 95% CI 2.15-3.65; OR 2.50, 95% CI 1.93-3.22, respectively). The PAF for hypertension due to the presence of any of the conventional risk factors and the PAF due to the presence of any of the overall risk factors were 30.2% and 39.0%, respectively. In conclusion, the impact of the overall risk factors, including the urinary Na/K ratio and sleep efficiency, on home hypertension was higher than that of conventional risk factors alone. The management of the urinary Na/K ratio and sleep efficiency as well as conventional risk factors might be important in the management of blood pressure.

  58. Correction: Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. 国際誌

    Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 44 (2) 262-262 2021年2月

    DOI: 10.1038/s41440-020-00547-4  

  59. Combined associations of liver enzymes and obesity with diabetes mellitus prevalence: The Tohoku Medical Megabank Community-based Cohort Study. 査読有り

    Fumi Itabashi, Takumi Hirata, Mana Kogure, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Naoki Nakaya, Ryohei Sasaki, Nobuyuki Takanashi, Kiyomi Sakata, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of epidemiology 32 (5) 221-227 2020年12月26日

    DOI: 10.2188/jea.JE20200384  

    詳細を見る 詳細を閉じる

    BACKGROUND: Alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) are enzymes associated with diabetes mellitus (DM) prevalence. However, limited information is available regarding the association of liver enzymes and DM consistently present in obese and non-obese individuals. We examined whether the combination of ALT and GGT enzymes is associated with the prevalence of DM regardless of obesity in a general Japanese population. METHODS: We conducted a cross-sectional study of 62,786 participants aged ≥20 years who lived in Miyagi and Iwate, Japan. We divided all the participants into eight groups according to the ALT level (low: <30 IU/L and high: ≥30 IU/L), GGT level (low: <50 IU/L and high: ≥50 IU/L), and the presence of obesity. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression analysis, adjusting for potential confounders, to determine associations of the combination of ALT and GGT levels and obesity with DM prevalence. RESULTS: Overall, 6,008 participants (9.6%) had DM. Compared to non-obese individuals with low ALT and GGT levels, the participants with high ALT and GGT levels had high ORs for DM in both obese (OR 4.06; 95% CI, 3.61-4.56) and non-obese groups (OR 2.19; 95% CI, 1.89-2.52). The obese group had high ORs for DM, even at low ALT and GGT levels. CONCLUSION: High ALT and GGT levels are associated with DM prevalence in obese and non-obese participants. This finding suggests that correcting ALT and GGT levels and controlling obesity are important for the prevention of DM.

  60. Impact of the Great East Japan Earthquake on the Employment Status and Mental Health Conditions of Affected Coastal Communities. 国際誌 査読有り

    Mitsuaki Katayanagi, Moe Seto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Yumi Sugawara, Akira Kodaka, Yusuke Utsumi, Hitomi Usukura, Yasuto Kunii, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    International journal of environmental research and public health 17 (21) 2020年11月3日

    DOI: 10.3390/ijerph17218130  

    詳細を見る 詳細を閉じる

    The Great East Japan Earthquake devasted the old community in coastal areas characterized by primary industry. The number of unemployed people increased from 150,000 to 190,000 after the earthquake. All of the adult residents of Shichigahama (18 years old or older), located in the coastal area of the Miyagi prefecture, whose houses were totally or majorly damaged, were recruited for a survey conducted in October 2011. All of the residents who responded with written informed consent were included in this study. Among 904 individuals who had a job before the Great East Japan Earthquake, 19% became unemployed. Concerning gender and age, 9% of young men, 34% of elderly men, 21% of young women, and 49% of elderly women became unemployed. Concerning the type of industry, 38%, 15%, and 16% of people who had belonged to the primary, secondary, and tertiary industries, respectively, before the disaster became unemployed. Those who became unemployed exhibited a significantly higher risk of insomnia compared to those who maintained jobs. The study pointed out the severe impact of the Great East Japan Earthquake on populations who had belonged to the primary industry, especially among elderly women, and its effect on sleep conditions.

  61. 本態性高血圧のリスク因子としてのナトリウム/カリウム(Na/K)比

    小暮 真奈, 田原 康玄, 寳澤 篤

    日本循環器病予防学会誌 55 (2) 114-123 2020年9月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  62. Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. 国際誌 査読有り

    Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 44 (2) 225-231 2020年8月17日

    DOI: 10.1038/s41440-020-00536-7  

    詳細を見る 詳細を閉じる

    Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.

  63. 非喫煙者における家庭での受動喫煙と高血圧の関連 東北メディカル・メガバンク計画地域住民コホート調査より

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    厚生の指標 67 (8) 1-8 2020年8月

    出版者・発行元:(一財)厚生労働統計協会

    ISSN:0452-6104

    詳細を見る 詳細を閉じる

    目的 近年,受動喫煙が高血圧と関連することを示す疫学研究が散見されるが,関連を示さない報告もあり,一定の結論は得られていない。また,受動喫煙に関して10年前と最近1年間の受動喫煙状況を反映した検討も行われていない。そこで,本研究では非喫煙者を対象とした家庭での10年前および最近1年間における受動喫煙の組み合わせと高血圧有病との関連につき,国内の大規模コホートデータを用いた検討を行った。方法 本研究は東北メディカル・メガバンク計画地域住民コホート調査のベースライン調査データ(2013年5月〜2016年3月に実施)を用いた断面研究である。宮城県在住で同調査のベースライン調査を特定健診共同参加型で受けた非喫煙者を解析対象とし,全解析対象者を10年前と最近1年間の家庭における受動喫煙の有無の組み合わせにより4群に分類した。家庭における10年前・最近1年間の受動喫煙の組み合わせと高血圧有病との関連を多変量ロジスティック回帰分析により検討し,10年前・最近1年間ともに受動喫煙のない者を参照群とした他群の高血圧有病に対するオッズ比と95%信頼区間を算出した。結果 本研究の解析対象者は15,381名(男性2,370名,女性13,011名)であり,高血圧の有病者は5,603名(36.4%)であった。最近1年間に家庭での受動喫煙を認めた者は1,961名(12.7%)であり,そのうち1,775名(90.5%)が10年前にも家庭での受動喫煙を認めた。多変量解析の結果,10年前・最近1年間ともに家庭での受動喫煙を認める者では,10年前・最近1年間ともに家庭での受動喫煙を認めない者と比較して,年齢・BMI・飲酒歴などの高血圧の危険因子と独立し,高血圧の有病と有意な正の関連を認めた(オッズ比1.15,95%信頼区間1.02-1.29)。男女別の解析では,10年前・最近1年間ともに家庭での受動喫煙を認める女性が10年前・最近1年間ともに家庭での受動喫煙を認めない女性と比較し,高血圧の有病と有意な正の関連を認めた(オッズ比1.15,95%信頼区間1.02-1.30)。結論 非喫煙者において家庭での長期間の受動喫煙があると年齢・BMIや飲酒歴などの古典的な高血圧の危険因子と独立して高血圧の有病リスクが有意に上昇した。公衆衛生上の観点からは家庭での受動喫煙の防止が肺がん・慢性閉塞性肺疾患や虚血性心疾患等の予防だけでなく血圧値の低下にも寄与する可能性が示唆された。(著者抄録)

  64. The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study. 国際誌 査読有り

    Yusuke Utsumi, Harumi Nemoto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Tomomi Suzuki, Moe Seto, Mitsuaki Katayanagi, Junko Okuyama, Atsushi Sakuma, Nami Honda, Yumi Sugawara, Halley Kaye-Kauderer, Yuta Takahashi, Akemi Kayama, Yoshihisa Kakuto, Masahiro Kohzuki, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    Sports medicine - open 6 (1) 30-30 2020年7月16日

    DOI: 10.1186/s40798-020-00259-6  

    詳細を見る 詳細を閉じる

    BACKGROUND: In communities affected by a disaster, walking can be a feasible form of physical exercise to improve physical and mental health conditions. However, there is limited evidence to support relationships between walking habits and mental health conditions in post-disaster settings. Cross-sectional epidemiological data obtained from a questionnaire survey (conducted in October 2017) of a community affected by the 2011 Great East Japan Earthquake (GEJE) was analyzed to evaluate the relationships. METHODS: Participants included individuals over 20 years of age (N = 718) from Shichigahama town in Miyagi prefecture, whose houses were significantly damaged by the GEJE. Their mental health conditions were assessed by the Kessler Psychological Distress Scale (K6), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Impact of Event Scale-Revised (IES-R). Additionally, the questionnaire asked the participants spent duration walking on average and their walking purpose by the following items: (1) longer than 60 min per day, (2) between 30 and 60 min per day, or (3) less than 30 min per day, and whether they walked to maintain healthy living habits (health-conscious walkers) or merely for transportation without considering health consequences (non-health-conscious walkers). These information and mental health indicators were analyzed using analysis of covariance (ANCOVA). RESULTS: Among the three walking duration groups of health-conscious walkers, there were significant differences in CES-D and K6 scores (p = 0.01 and p = 0.04), but not in IES-R scores, considering age, gender, and alcohol drinking habits as covariates. CES-D score was significantly higher among short walkers (p = 0.004). Among the three walking duration groups of non-health-conscious walkers, there were significant differences in avoidance symptoms, the subdomain of IES-R (p = 0.01), but not in CES-D, K6, and total IES-R scores, considering the variants. CONCLUSION: Our study suggests that walking durations may positively affect mood, but not PTSR, only when walking is performed with the purpose of maintaining healthy living habits. Walking durations were negatively associated with avoidance symptoms among non-health-conscious walkers in the community affected by the GEJE, indicating that the disaster may have had a long-lasting impact on walking habits.

  65. Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. 国際誌 査読有り

    Maiko Wagata, Mana Kogure, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Akira Narita, Hirohito Metoki, Mami Ishikuro, Masahiro Kikuya, Kozo Tanno, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Masayuki Yamamoto, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

    Hypertension research : official journal of the Japanese Society of Hypertension 43 (11) 1277-1283 2020年5月13日

    DOI: 10.1038/s41440-020-0463-8  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    We investigated whether the association between a history of hypertensive disorders of pregnancy (HDP) and hypertension in later life varies by age group and the effect of obesity on the association between a history of HDP and hypertension in later life. This cross-sectional population-based study was conducted at the Tohoku Medical Megabank Project in Miyagi and Iwate, Japan. The study subjects were 33,412 parous women of 20 years of age and older. We used multivariate logistic regression analysis to assess the association between a history of HDP and hypertension. We constructed a composite variable that combined a history of HDP (±) and overweight/obesity (BMI ≥ 25 kg/m2) (±), resulting in four categories, and analyzed the risks of each category by multivariate logistic regression analysis. In total, 1585 (4.7%) women had a history of HDP. The prevalence of hypertension was higher in women with HDP (51.4%) than in those without HDP (36.8%; p < 0.01). The adjusted odds ratios (ORs) for hypertension in women with HDP in their 30s, 40s, 50s, 60s, and 70s or older were 3.63, 1.84, 2.15, 1.48, and 1.86, respectively. In the interaction analysis, the association between a history of HDP and hypertension was stronger in women in their 30s-50s than in women who were 60 or older (p = 0.057). The adjusted ORs for hypertension were higher in overweight/obese women with HDP than in their nonoverweight/obese counterparts in all age groups (30s: 27.17 vs. 2.22; 70s: 4.75 vs. 1.90). In conclusion, the association between HDP and later hypertension was stronger in younger women and in obese women in the 30-70 age group.

  66. Association of serum adiponectin levels and body mass index with worsening depressive symptoms in elderly individuals: a 10-year longitudinal study. 国際誌 査読有り

    Cong Huang, Mana Kogure, Yasutake Tomata, Yumi Sugawara, Atsushi Hozawa, Haruki Momma, Ichiro Tsuji, Ryoichi Nagatomi

    Aging & mental health 24 (5) 725-731 2020年5月

    DOI: 10.1080/13607863.2019.1584877  

    ISSN:1360-7863

    詳細を見る 詳細を閉じる

    Objectives: Data regarding the association between adiponectin levels and body mass index (BMI) and long-term changes in depressive symptoms are limited and inconsistent. Thus, we investigated whether circulating adiponectin levels and BMI were independently and combinedly correlated to longitudinal changes in depressive symptoms.Methods: This prospective cohort study evaluated 269 elderly Japanese individuals aged ≥70 years who participated in the Tsurugaya Project conducted between 2002 and 2012. A short form of the Geriatric Depression Scale (GDS) was used to assess depressive status. Serum adiponectin levels were measured using an enzyme-linked immunosorbent assay or a latex particle-enhanced turbidimetric immunoassay. BMI was calculated as body weight (kg)/height (m2).Results: Multiple linear regression analysis revealed that baseline serum adiponectin levels were positively associated with changes in GDS scores (β = 0.14, P = 0.035). However, no association was observed after adjusting for BMI (β = 0.09, P = 0.185). Low BMI was associated with increased GDS scores at the 10-year follow-up (β = -0.14, P = 0.033). Participants with a combination of high adiponectin levels and low BMI had a 3.3-fold higher risk of worsening depressive symptoms than those with low adiponectin levels and high BMI (odds ratio: 3.35, 95% confidence interval: 1.60-7.00; P = 0.001).Conclusions: This longitudinal study indicated that high serum adiponectin levels and low BMI were both associated with worsening depressive symptoms among older Japanese individuals. Furthermore, the combination of high adiponectin levels and low BMI was associated with worsening depressive symptoms.

  67. Living Arrangement Affects Urine Na/k Ratio Among 44,085 Residents: Tohoku Medical Megabank Project Community-based Cohort Study 査読有り

    Takahiro Mikami, Kozo Tanno, Ryouhei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Mana Kogure, Atsushi Hozawa, Kiyomi Sakata, Makoto Sasaki

    Circulation 141 (Suppl_1) 2020年3月3日

    出版者・発行元:None

    DOI: 10.1161/circ.141.suppl_1.p483  

    ISSN:0009-7322

    eISSN:1524-4539

  68. Relationship between calcium intake and impaired activities of daily living in a Japanese population: NIPPON DATA90. 査読有り

    Mana Kogure, Naho Tsuchiya, Akira Narita, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Atsushi Hozawa, Takehito Hayakawa, Nagako Okuda, Naoko Miyagawa, Aya Kadota, Takayoshi Ohkubo, Yoshitaka Murakami, Kiyomi Sakata, Katsuyuki Miura, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima

    Journal of epidemiology 31 (2) 119-124 2020年2月8日

    DOI: 10.2188/jea.JE20190234  

    詳細を見る 詳細を閉じる

    BACKGROUND: Major reasons for long-term care insurance certification in Japan are stroke, dementia and fracture. These diseases are reported to be associated with calcium intake. This study examined the association between calcium intake and impaired activities of daily living (ADL) using the data from NIPPON DATA90, consisting of representative sample of the Japanese population. METHODS: A population-based nested case control study was performed. A baseline survey was conducted in 1990, followed by ADL surveys of individuals ≥65 years old in 2000. Individuals with impaired ADL and selected age- and sex-matched controls were then identified. We obtained 132 pairs. Calcium intake was energy-adjusted using the residual method. The association between calcium intake and impaired ADL was examined using conditional logistic regression models. To assess the accuracy of the estimates, we conducted bootstrap analyses. RESULTS: The adjusted odds ratios (ORs) for impaired ADL compared with the group with a calcium intake of <476 mg/day were 0.72 (95% confidence interval, 95% CI: 0.37-1.40) for the 476-606 mg/day group and 0.44 (0.21-0.94) for the ≥607 mg/day group in 2000 (P for linear trend = 0.03). After the bootstrap analyses, the inverse relationship unchanged (median OR per 100-mg rise in calcium intake: 0.87 [1,000 resamplings], 95% CI: 0.76-0.97). CONCLUSIONS: After bootstrap analyses, calcium intake was inversely associated with impaired ADL, 10 years after the baseline survey.

  69. Dietary Inflammatory Index Positively Associated With High-Sensitivity C-Reactive Protein Level in Japanese From NIPPON DATA2010. 査読有り

    Yunqing Yang, Atsushi Hozawa, Mana Kogure, Akira Narita, Takumi Hirata, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Toshiharu Ninomiya, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Journal of epidemiology 30 (2) 98-107 2020年2月5日

    DOI: 10.2188/jea.JE20180156  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BACKGROUND: It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, the Dietary Inflammatory Index (DII®) was developed to assess the inflammatory potential of the overall diet. The DII has been reported as relevant to various diseases but has not been validated in Japanese. Thus, in the present study, we analyzed the relationship between DII scores and high-sensitivity C-reactive protein (hs-CRP) levels in a Japanese population. METHODS: Data of the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010), which contained 2,898 participants aged 20 years or older from the National Health and Nutrition Survey of Japan (NHNS2010), were analyzed. Nutrient intakes derived from 1-day semi-weighing dietary records were used to calculate DII scores. Energy was adjusted using the residual method. Levels of hs-CRP were evaluated using nephelometric immunoassay. Multiple linear regression analyses were performed. RESULTS: After adjusting for age, sex, smoking status, BMI, and physical activity, a significant association was observed between DII scores and log(CRP+1) (standard regression coefficient = 0.05, P < 0.01). Although it was not statistically significant, the positive association was consistently observed in almost all age-sex subgroups and the non-smoker subgroup. CONCLUSIONS: The current study confirmed that DII score was positively associated with hs-CRP in Japanese.

  70. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. 国際誌 査読有り

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    International journal of epidemiology 49 (1) 18-19 2020年2月1日

    DOI: 10.1093/ije/dyz169  

    ISSN:0300-5771

  71. Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. 査読有り

    Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

    Journal of epidemiology 31 (1) 65-76 2020年1月11日

    DOI: 10.2188/jea.JE20190271  

    ISSN:0917-5040

    詳細を見る 詳細を閉じる

    BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.

  72. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. 国際誌 査読有り

    Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 43 (1) 23-29 2020年1月

    DOI: 10.1038/s41440-019-0329-0  

    ISSN:0916-9636

    詳細を見る 詳細を閉じる

    Few studies have reported the relationship between reduced sleep efficiency and the prevalence of hypertension independent of sleep duration in Japan. This study aimed to evaluate whether reduced sleep efficiency, measured using an objective device for >1 week, was related to an increased prevalence of hypertension independent of sleep duration in the general Japanese population. We conducted a cross-sectional study of 904 participants aged ≥20 years who lived in Miyagi Prefecture, Japan. Sleep efficiency was measured using a contactless biomotion sleep sensor for 10 continuous days. The participants were classified into two groups according to their sleep efficiency: reduced (<90%) or not reduced (≥90%). Hypertension was defined as morning home blood pressure ≥135/85 mmHg or self-reported treatment for hypertension. Multivariable logistic regression models were used to obtain odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationship between sleep efficiency and hypertension adjusted for potential confounders. The results showed that two hundred and ninety-four individuals (32.5%) had reduced sleep efficiency, and 331 (36.6%) had hypertension. Individuals with reduced sleep efficiency had a higher body mass index and shorter sleep duration. In the multivariable analysis, reduced sleep efficiency was significantly related to an increased prevalence of hypertension (OR, 1.62; 95% CI, 1.15-2.28). In conclusion, reduced sleep efficiency was significantly related to an increased prevalence of hypertension in Japanese adults. Improvements in sleep efficiency may be important to reduce blood pressure in Japanese adults.

  73. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. 国際誌 査読有り

    Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension 43 (1) 62-71 2020年1月

    DOI: 10.1038/s41440-019-0335-2  

    ISSN:0916-9636

    詳細を見る 詳細を閉じる

    Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, and multiple measurements of the casual urinary Na/K ratio are more strongly correlated with the 24-h urinary Na/K ratio than a single measurement. Multiple measurements of the urinary Na/K ratio might be more strongly associated with hypertension. We aimed to determine the association between multiple measurements of the casual urinary Na/K ratio and home hypertension compared with a single measurement. A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old and participated in the Tohoku Medical Megabank Project Cohort Study. We targeted 3273 subjects who borrowed home blood pressure (HBP) monitors and urinary Na/K ratio monitors for 10 consecutive days. The association between the urinary Na/K ratio and home hypertension (HBP ≥ 135/85 mmHg or under treatment for hypertension) was examined using multiple logistic regression models. To compare the prediction of home hypertension using multiple measurements with that using a single measurement, we calculated the area under the receiver operating characteristic curve (AUROC). Multiple measurements of the urinary Na/K ratio strongly related to home hypertension were better than 1 or 2 days of measurement (adjusted odds ratio of home hypertension per unit increase in urinary Na/K ratio over 6 days: 1.13-1.15). The AUROC of the urinary Na/K ratio measurement for home hypertension was stable after 5 days (AUROC = 0.779). In conclusion, multiple measurements of the urinary Na/K ratio are strongly related to home hypertension. This finding suggests that multiple measurements of the urinary Na/K ratio are useful for evaluating home hypertension.

  74. Significant Association of House Collapse With High Urine Na/K Ratios Among 24,580 Coastal Residents Who Survived the Great East Japan Earthquake 査読有り

    Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Atsushi Hozawa, Mana Kogure, Shinichi Kuriyama, Ichiro Tsuji, Mamoru Sato, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki

    CIRCULATION 139 2019年

    出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS

    DOI: 10.1161/circ.139.suppl_1.P086  

    ISSN:0009-7322

    eISSN:1524-4539

  75. Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake 査読有り

    Naoki Nakaya, Harumi Nemoto, Carine Yi, Ayako Sato, Kotomi Shingu, Tomoka Shoji, Shosuke Sato, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Yumi Sugawara, Zhiqian Yu, Nicole Gunawansa, Shinichi Kuriyama, Osamu Murao, Takeshi Sato, Fumihiko Imamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    International Journal of Disaster Risk Reduction 28 206-213 2018年6月1日

    出版者・発行元:Elsevier Ltd

    DOI: 10.1016/j.ijdrr.2018.02.037  

    ISSN:2212-4209

    詳細を見る 詳細を閉じる

    The effectiveness of tsunami drills in guiding evacuation behavior remains uninvestigated. Accumulation of evidence regarding the effectiveness of tsunami drills would be beneficial for improving survival and health of communities to be inundated by a tsunami. A questionnaire to inquire participants' location at the onset of the Great East Japan Earthquake and experience of the tsunami was issued as part of a survey of total adult residents of Shichigahama town whose houses were significantly damaged by the disaster. Along with the location information, self-reported information on participation in tsunami disaster drills and attendance of a lecture about tsunamis before the disaster and whether the participants evacuated after the earthquake was subjected to multiple logistic regression analyses adjusted for potential confounding factors. Amongst the 2314 participants who were present in the town at the onset of the disaster and completed the questionnaires, 1560 (67%) evacuated after the earthquake. The rate of evacuation was significantly higher amongst the population who participated in tsunami disaster drills before the event than amongst those who did not participate (multivariate-adjusted odds ratio [MOR] = 1.99, 95% confidence interval [CI] = 1.53–2.61, p &lt 0.01). However, other experience of earthquake and tsunami disaster prevention before the event did not affect evacuation behavior (MOR = 0.86–1.16). A survey of the population who survived the catastrophe provides initial evidence to advocate the administration of tsunami drills in seaside communities to enhance the evacuation behavior immediately after the disaster onset.

  76. Factors Related to Participation in Health Examinations for Japanese National Health Insurance: NIPPON DATA2010. 査読有り

    Imamura H, Kogure M, Kita Y, Nakagawa H, Hozawa A, Okamura T, Murakami Y, Nishi N, Okuda N, Kadota A, Ohkubo T, Ueshima H, Okayama A, Miura K

    Journal of epidemiology 28 Suppl 3 S53-S58 2018年

    DOI: 10.2188/jea.JE20170251  

    ISSN:0917-5040

  77. Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011 査読有り

    Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Jun Aida, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    PSYCHIATRY AND CLINICAL NEUROSCIENCES 71 (1) 52-60 2017年1月

    出版者・発行元:WILEY

    DOI: 10.1111/pcn.12467  

    ISSN:1323-1316

    eISSN:1440-1819

    詳細を見る 詳細を閉じる

    AimSocial capital has been considered an important factor affecting mental-health outcomes, such as psychological distress in post-disaster settings. Although disaster-related house condition and displacement could affect both social capital and psychological distress, limited studies have investigated interactions. This study aimed to examine the association between social capital and psychological distress, taking into consideration the interaction of disaster-related house condition after the Great East Japan Earthquake of 2011. MethodsUsing data from 3793 adults living in Shichigahama, Miyagi Prefecture, Japan, we examined the association between social capital measured by generalized trust and psychological distress measured by the Kessler 6 scale. We conducted stratified analysis to investigate an interaction of house destruction and displacement. Multivariate analyses taking into consideration the interaction were performed. ResultsIn the crude analysis, low social capital (odds ratio [OR] 4.46; 95% confidence interval [CI], 3.27-6.07) and large-scale house destruction (OR 1.96; 95%CI, 1.47-2.62) were significantly associated with psychological distress. Stratified analyses detected an interaction with house destruction and displacement (P for interaction = 0.04). Multivariate analysis with interaction term revealed that individuals with low social capital, large-scale house damage, and displacement were at greater risk of psychological distress, corresponding to adjusted OR of 5.78 (95%CI, 3.48-9.60). ConclusionIn the post-disaster setting, low social capital increased the risk of psychological distress, especially among individuals who had large-scale house destruction. Among the participants with severe disaster damage, high social capital would play an important role in protecting mental health.

  78. Does the flushing response modify the relationship between alcohol intake and hypertension in the Japanese population? NIPPON DATA2010 査読有り

    Mana Kogure, Naho Tsuchiya, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naomi Miyamatsu, Hideo Tanaka, Ichiro Wakabayashi, Aya Higashiyama, Nagako Okuda, Naoyuki Takashima, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    HYPERTENSION RESEARCH 39 (9) 670-679 2016年9月

    出版者・発行元:NATURE PUBLISHING GROUP

    DOI: 10.1038/hr.2016.46  

    ISSN:0916-9636

    eISSN:1348-4214

    詳細を見る 詳細を閉じる

    The influence of alcohol intake on hypertension may vary depending on the flushing response, but this relationship has not been confirmed. The relationship between alcohol intake and hypertension was examined according to the flushing response in a representative sample of the Japanese population. Participants in the National Health and Nutrition Survey in 2010 were asked to participate in the baseline survey of NIPPON DATA2010. Here, we investigated the relationship between alcohol intake and hypertension according to the flushing response. Statistical analyses were performed in a cross-sectional manner using multiple logistic regression models after adjusting for age, body mass index, smoking status, present illness of diabetes mellitus and present illness of dyslipidemia. Of the 1139 men and 1263 women, 659 and 463, respectively, had hypertension. Among the men, alcohol intake was positively associated with hypertension, regardless of the flushing response (P for linear trend both &lt;0.05). This positive relationship was observed for both users and non-users of antihypertensive drugs. No interaction with the flushing response was observed (P for interaction=0.360). In women, although the direction differed between flushers and non-flushers, the association between alcohol intake and hypertension was not significant, regardless of flushing response. In conclusion, In Japanese men, alcohol intake was positively associated with hypertension in a manner that was not influenced by the flushing response.

  79. Housing type after the Great East Japan Earthquake and loss of motor function in elderly victims: a prospective observational study 査読有り

    Kumiko Ito, Yasutake Tomata, Mana Kogure, Yumi Sugawara, Takashi Watanabe, Tadayoshi Asaka, Ichiro Tsuji

    BMJ OPEN 6 (11) e012760 2016年

    出版者・発行元:BMJ PUBLISHING GROUP

    DOI: 10.1136/bmjopen-2016-012760  

    ISSN:2044-6055

    詳細を見る 詳細を閉じる

    Objective: Previous studies have reported that elderly victims of natural disasters might be prone to a subsequent decline in motor function. Victims of the Great East Japan Earthquake (GEJE) relocated to a wide range of different types of housing. As the evacuee lifestyle varies according to the type of housing available to them, their degree of motor function loss might also vary accordingly. However, the association between postdisaster housing type and loss of motor function has never been investigated. The present study was conducted to investigate the association between housing type after the GEJE and loss of motor function in elderly victims. Methods: We conducted a prospective observational study of 478 Japanese individuals aged &gt;= 65 years living in Miyagi Prefecture, one of the areas most significantly affected by the GEJE. Information on housing type after the GEJE, motor function as assessed by the Kihon checklist and other lifestyle factors was collected by interview and questionnaire in 2012. Information on motor function was then collected 1 year later. The multiple logistic regression model was used to estimate the multivariate adjusted ORs of motor function loss. Results: We classified 53 (11.1%) of the respondents as having loss of motor function. The multivariate adjusted OR (with 95% CI) for loss of motor function among participants who were living in privately rented temporary housing/rental housing was 2.62 (1.10 to 6.24) compared to those who had remained in the same housing as that before the GEJE, and this increase was statistically significant. Conclusions: The proportion of individuals with loss of motor function was higher among persons who had relocated to privately rented temporary housing/rental housing after the GEJE. This result may reflect the influence of a move to a living environment where few acquaintances are located (lack of social capital).

  80. 東日本大震災の被災地における運動教室の効果 宮城県被災者健康調査における経時的研究

    遠又 靖丈, 佐藤 紀子, 小暮 真奈, 須藤 彰子, 今井 雪輝, 青木 眸, 杉山 賢明, 鈴木 玲子, 菅原 由美, 渡邉 崇, 永富 良一, 辻 一郎

    日本公衆衛生雑誌 62 (2) 66-72 2015年2月

    出版者・発行元:日本公衆衛生学会

    ISSN:0546-1766

    詳細を見る 詳細を閉じる

    目的 被災地で心理的ストレス、活動量低下の問題が懸念されており、運動教室などが行われているが、その効果は十分に検討されていない。そこで、被災地における運動教室の心身への健康効果を検証した。方法 平成24年度に、宮城県石巻市の雄勝地区・牡鹿地区の住民を対象とした「被災者健康調査」の一環として、運動教室を実施した。運動教室の参加者と非参加者で健康状態の推移が異なるかを検討するため、同地区での「被災者健康調査」のデータから運動教室の参加者81人とベースライン特性の似た運動教室の非参加者81人を傾向スコアマッチングで抽出した。マッチングには性別、年齢、地域のほか、6種のアウトカム変数を用いた。アウトカム指標は、K6(心理的ストレスの指標)、主観的健康感、睡眠時間、睡眠の質、外出頻度、歩行時間(1日あたり)とした。解析には線形混合モデルを用い、有意水準はP&lt;0.05とした。結果 K6得点の経時変化は、参加者と非参加者で有意差を認めなかった(P=0.913)。主観的健康感(P=0.011)、外出頻度(P=0.002)は有意な改善を認めたが、睡眠時間、睡眠の質、歩行時間では経時変化に有意差を認めなかった。結論 運動教室に参加した者では、主観的健康感や外出頻度は有意に改善した。被災地における運動介入は、健康感の改善に有効な対策であることが示唆された。(著者抄録)

  81. [Health effects of interventions to promote physical activity in survivors of the 2011 Great East Japan Earthquake. A longitudinal study]. 査読有り

    Yasutake Tomata, Noriko Sato, Mana Kogure, Syoko Suto, Yuki Imai, Hitomi Aoki, Kemmyo Sugiyama, Reiko Suzuki, Yumi Sugawara, Takashi Watanabe, Ryoichi Nagatomi, Ichiro Tsuji

    [Nihon koshu eisei zasshi] Japanese journal of public health 62 (2) 66-72 2015年

    DOI: 10.11236/jph.62.2_66  

    ISSN:0546-1766

    詳細を見る 詳細を閉じる

    OBJECTIVES: Interventions that promote physical activity to prevent psychological distress and disuse syndromes were carried out in disaster-stricken areas. However, the effect of these interventions to promote physical activity in disaster-stricken areas has not yet been fully clarified. The purpose of this study was to examine the health effects of promoting physical activity in a disaster-stricken area. METHODS: We conducted an exercise intervention as part of a health survey project among residents of Ishinomaki-city, Miyagi, Japan in 2012. To determine if changes in health condition differed between intervention participants and nonparticipants, health condition data from 81 participants were compared with data from 81 nonparticipants selected by propensity score matching. Factors including sex, age, original address (pre-quake), and six outcome variables (psychological distress [K6 score], subjective health status, sleep duration, sleep quality, frequency of outings, and time spent walking) were used for matching. A linear mixed model was used for statistical analysis. RESULTS: There were no significant differences in K6 score between participants and nonparticipants (P=0.913). Significant improvements were observed in subjective health status (P=0.011) and outing frequency (P=0.002), but not in other outcome variables. CONCLUSION: Subjective health status and outing frequency were significantly improved among participants of the exercise intervention. Exercise intervention may be an effective public health strategy in disaster-stricken areas.

  82. The association between self-reported history of physical diseases and psychological distress in a community-dwelling Japanese population: the Ohsaki Cohort 2006 Study 査読有り

    Naoki Nakaya, Mana Kogure, Kumi Saito-Nakaya, Yasutake Tomata, Toshimasa Sone, Masako Kakizaki, Ichiro Tsuji

    EUROPEAN JOURNAL OF PUBLIC HEALTH 24 (1) 45-49 2014年2月

    出版者・発行元:OXFORD UNIV PRESS

    DOI: 10.1093/eurpub/ckt017  

    ISSN:1101-1262

    eISSN:1464-360X

    詳細を見る 詳細を閉じる

    Background: Patients with physical disease are known to suffer considerable psychological distress. Social support may confound the association between physical disease and psychological distress. Population-based epidemiological studies have not been conducted on the association between history of physical disease, psychological distress and social support. Methods: Using cross-sectional data from 2006, we studied 43 487 community-dwelling people aged epsilon 40 years living in Japan. We examined the association between 13 self-reported histories of physical disease and psychological distress evaluated using the Kessler 6-item psychological distress scale (K6), defined as epsilon 13 points out of 24. To investigate the association, we performed multiple logistic regression analyses adjusted for age, gender, social support and possible confounders. Social support, as the interaction between physical disease and psychological depression, was tested through the addition of cross-product terms to the multivariate-adjusted model. Results: The following histories of physical disease were found significantly and positively associated with psychological distress: cancer, diabetes mellitus, hyperlipidemia, hypertension, myocardial infarction, stroke, gastric or duodenal ulcer, liver disease, arthritis, osteoporosis, kidney disease and fall or fracture (odds ratio, 1.2-2.3). Social support did not modify the association between most histories of physical disease and psychological distress. Conclusions: Subjects with a history of physical disease were significantly and positively associated with psychological distress, and social support did not modify this association for most physical diseases. Even after patients have left hospital following treatment for physical disease, they require continuous monitoring for psychological distress by doctors and paramedics.

︎全件表示 ︎最初の5件までを表示

MISC 150

  1. 大規模観察研究におけるランダム男女ペア間の循環代謝リスク因子の類似性の検討

    中谷 直樹, 中谷 久美, 土屋 菜歩, 曽根 稔雅, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 目時 弘仁, 小原 拓, 石黒 真美, 寳澤 篤, 栗山 進一

    Journal of Epidemiology 33 (Suppl.1) 173-173 2023年2月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  2. これからの循環器病予防研究者育成に何が必要か? 循環器病予防研究者からの提言

    桑原 政成, 佐藤 倫広, 小暮 真奈, 田中 伸弥, 辰巳 友佳子, 矢野 裕一朗, 東條 美奈子, 大久保 孝義

    日本循環器病予防学会誌 57 (3) 214-219 2022年11月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  3. 正常高値血圧、高値血圧における中心血圧、頸動脈内膜中膜厚と新規高血圧発症の関連

    時岡 紗由理, 中谷 直樹, 中谷 久美, 高瀬 雅仁, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 千葉 一平, 目時 弘仁, 村上 任尚, 佐藤 倫広, 小原 拓, 栗山 進一, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 44回 80-80 2022年10月

    出版者・発行元:(NPO)日本高血圧学会

  4. 年齢と骨梁面積率との関連 年齢階級別の検討 ToMMo地域住民コホート調査

    菅野 郁美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 中村 智洋, 小原 拓, 目時 弘仁, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 81回 203-203 2022年9月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  5. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌 (71) 28-28 2022年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  6. 地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと 健診機関とのタイアップ

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 菅野 郁美, 板橋 芙美, 黒川 悦子, 大川 亜美, 宮川 健, 永吉 翔, 牛田 悠介, 清水 友紀子, 上田 宏幸, 土屋 菜歩, 中谷 直樹, 寳澤 篤

    総合健診 49 (1) 205-205 2022年1月

    出版者・発行元:(一社)日本総合健診医学会

    ISSN:1347-0086

    eISSN:1884-4103

  7. 脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

    高瀬 雅仁, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 土屋 菜歩, 平田 匠, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 32 (Suppl.1) 126-126 2022年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  8. 脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

    高瀬 雅仁, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 土屋 菜歩, 平田 匠, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 32 (Suppl.1) 126-126 2022年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  9. 地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと 健診機関とのタイアップ

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 菅野 郁美, 板橋 芙美, 黒川 悦子, 大川 亜美, 宮川 健, 永吉 翔, 牛田 悠介, 清水 友紀子, 上田 宏幸, 土屋 菜歩, 中谷 直樹, 寳澤 篤

    総合健診 49 (1) 205-205 2022年1月

    出版者・発行元:(一社)日本総合健診医学会

    ISSN:1347-0086

    eISSN:1884-4103

  10. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 80回 219-219 2021年11月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  11. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 80回 219-219 2021年11月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  12. 特定健康診査時に尿ナトカリ計で4年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

    小暮 真奈, 須藤 庸子, 及川 満代, 土屋 菜歩, 平田 匠, 畑中 里衣子, 佐々木 久美子, 黒川 悦子, 宮川 健, 牛田 悠介, 上田 宏幸, 佐々木 秀美, 本間 洋子, 中谷 直樹, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 43回 261-261 2021年10月

    出版者・発行元:(NPO)日本高血圧学会

  13. 東日本大震災に伴う災害による健康影響に関する文献レビュー

    高瀬雅仁, 五十嵐有香, 中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 中村智洋, 後岡広太郎, 後岡広太郎, 寳澤篤

    日本循環器病予防学会誌 56 (3) 2021年

    ISSN:1346-6267

  14. 脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

    高瀬 雅仁, 中村 智洋, 平田 匠, 小暮 真奈, 板橋 芙美, 土屋 菜歩, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 101-101 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  15. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology 31 (Suppl.) 116-116 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  16. 住環境の主観的評価と心理的苦痛との関連

    菅野 郁美, 長谷川 兼一, 中村 智洋, 土屋 菜歩, 小暮 真奈, 板橋 芙美, 成田 暁, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 143-143 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  17. 脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

    高瀬 雅仁, 中村 智洋, 平田 匠, 小暮 真奈, 板橋 芙美, 土屋 菜歩, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 101-101 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  18. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology 31 (Suppl.) 116-116 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  19. 住環境の主観的評価と心理的苦痛との関連

    菅野 郁美, 長谷川 兼一, 中村 智洋, 土屋 菜歩, 小暮 真奈, 板橋 芙美, 成田 暁, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology 31 (Suppl.) 143-143 2021年1月

    出版者・発行元:(一社)日本疫学会

    ISSN:0917-5040

    eISSN:1349-9092

  20. 東日本大震災被災者の居住環境の変化による他者との交流習慣・メンタルヘルスへの影響

    鈴木 智美, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 中谷 直樹, 寳澤 篤, 辻 一郎, 富田 博秋

    日本公衆衛生学会総会抄録集 79回 415-415 2020年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  21. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌 (52) 20-20 2020年4月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  22. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌 (52) 20-20 2020年4月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  23. 食品摂取回避行動の実態と関連要因の検討:東北メディカル・メガバンク計画地域住民コホート調査

    坪田(宇津木)恵, 丹野高三, 丹野高三, 佐々木亮平, 佐々木亮平, 高梨信之, 事崎由佳, 小暮真奈, 寳澤篤, 坂田清美, 坂田清美

    日本疫学会学術総会講演集(Web) 30th 2020年

  24. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  25. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  26. 遺伝因子と飲酒量の交互作用と随時血圧値の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 小暮 真奈, 田宮 元, 中村 智洋, 土屋 菜歩, 平田 匠, 丹野 高三, 清水 厚志, 菅原 準一, 栗山 進一, 辻 一郎, 木下 賢吾, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 216-216 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  27. 睡眠の測定機器から得られた睡眠状況と心理的苦痛との関連

    五十嵐 有香, 小暮 真奈, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 宮川 健, 宇留野 晃, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 223-223 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  28. 家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 223-223 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  29. 高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討 東北メディカル・メガバンク計画コホート調査の成果から

    小暮 真奈, 平田 匠, 土屋 菜歩, 中村 智洋, 宮川 健, 小清水 宏, 小原 拓, 目時 弘仁, 宇留野 晃, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 287-287 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  30. 特定健康診査時に尿ナトカリ計で2年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

    小暮 真奈, 須藤 庸子, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 宮川 健, 中谷 直樹, 佐々木 秀美, 本間 洋子, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 287-287 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  31. 非喫煙者における受動喫煙の有無と家庭高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 288-288 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  32. 血漿メタボロームと頸動脈内膜中膜肥厚の関連

    寳澤 篤, 小柴 生造, 平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 元池 育子, 三枝 大輔, 峯岸 直子, 栗山 進一, 田宮 元, 辻 一郎, 木下 賢吾, 呉 繁夫

    日本高血圧学会総会プログラム・抄録集 42回 304-304 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  33. 配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査 査読有り

    中谷 直樹, 土屋 菜歩, 成田 暁, 石黒 真美, 目時 弘仁, 平田 匠, 小暮 真奈, 中村 智洋, 後岡 広太郎, 中谷 久美, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 224-224 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  34. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連 査読有り

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  35. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査 査読有り

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 212-212 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  36. 高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討 東北メディカル・メガバンク計画コホート調査の成果から 査読有り

    小暮 真奈, 平田 匠, 土屋 菜歩, 中村 智洋, 宮川 健, 小清水 宏, 小原 拓, 目時 弘仁, 宇留野 晃, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 287-287 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  37. 非喫煙者における受動喫煙の有無と家庭高血圧の関連 査読有り

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集 42回 288-288 2019年10月

    出版者・発行元:(NPO)日本高血圧学会

  38. 家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 223-223 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  39. 配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査

    中谷 直樹, 土屋 菜歩, 成田 暁, 石黒 真美, 目時 弘仁, 平田 匠, 小暮 真奈, 中村 智洋, 後岡 広太郎, 中谷 久美, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集 78回 224-224 2019年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  40. 一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

    良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 宮崎真理子, 寳澤篤

    日本腎臓学会誌 61 (3) 332-332 2019年5月15日

    出版者・発行元:(一社)日本腎臓学会

    ISSN:0385-2385

    eISSN:1884-0728

  41. 尿ナトリウム/カリウム比を健診に追加することで高血圧のPAFが12%増加し約50%に:COI東北拠点と登米市の共同研究

    小暮真奈, 小暮真奈, 須藤庸子, 中村智洋, 中村智洋, 土屋菜歩, 土屋菜歩, 平田匠, 平田匠, 成田暁, 成田暁, 宮川健, 宮川健, 中谷直樹, 中谷直樹, 佐々木秀美, 寳澤篤, 寳澤篤

    日本循環器病予防学会誌 54 (2) 122 2019年4月11日

    ISSN:1346-6267

  42. 非肥満者において肝機能指標の組み合わせと糖尿病の関連は飲酒により異なるか

    一迫芙美, 平田匠, 平田匠, 土屋菜歩, 土屋菜歩, 中村智洋, 中村智洋, 成田暁, 成田暁, 小暮真奈, 小暮真奈, 中谷直樹, 中谷直樹, 栗山進一, 栗山進一, 呉繁夫, 呉繁夫, 寳澤篤, 寳澤篤

    日本循環器病予防学会誌 54 (2) 115 2019年4月11日

    ISSN:1346-6267

  43. 東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

    平田 匠, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐藤 衛, 菊谷 昌浩, 石垣 泰, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫

    糖尿病 62 (Suppl.1) S-304 2019年4月

    出版者・発行元:(一社)日本糖尿病学会

    ISSN:0021-437X

    eISSN:1881-588X

  44. 東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

    平田 匠, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐藤 衛, 菊谷 昌浩, 石垣 泰, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫

    糖尿病 62 (Suppl.1) S-304 2019年4月

    出版者・発行元:(一社)日本糖尿病学会

    ISSN:0021-437X

  45. 新規リスク因子(尿ナトカリ比高値・睡眠効率不良)の高血圧への集団寄与危険割合の検討

    平田 匠, 中村 智洋, 小暮 真奈, 宮川 健, 小原 拓, 中谷 直樹, 宇留野 晃, 菅原 準一, 栗山 進一, 寳澤 篤

    日本循環器病予防学会誌 54 (2) 121-121 2019年4月

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  46. 成人における客観的睡眠効率と高血圧有病率との関連(Association of Objective Sleep Efficiency with Prevalence of Hypertension in Adults) 査読有り

    平田 匠, 中村 智洋, 小暮 真奈, 成田 暁, 宮川 健, 後岡 広太郎, 土屋 菜歩, 小原 拓, 中谷 直樹, 栗山 進一, 寳澤 篤

    日本循環器学会学術集会抄録集 83回 OJ22-4 2019年3月

    出版者・発行元:(一社)日本循環器学会

  47. 東日本大震災による津波避難訓練の有効性

    中谷直樹, 根本晴美, YI Carine J, 佐藤文子, 新宮古都美, 庄子朋香, 佐藤翔輔, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 菅原由美, 兪志前, GUNAWANSA Nicole, 栗山進一, 村尾修, 佐藤健, 今村文彦, 富田博秋

    宮城県公衆衛生学会会誌 (51) 12 2019年3月

    ISSN:0912-747X

  48. 未治療高血圧者に対する平成29年度特定健康診査時の尿ナトカリ比及び保健指導後の医療受診動向について

    鈴木智美, 鈴木智美, 板橋由紀, 小暮真奈, 堀籠千賀, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 渡邊真孝, 小野誠司, 渡辺文昭, 寳澤篤

    宮城県公衆衛生学会会誌 (51) 13-13 2019年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  49. 東北メディカル・メガバンク機構―地域住民コホート調査詳細二次調査

    寳澤篤, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫

    宮城県公衆衛生学会会誌 (51) 17-17 2019年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  50. 東日本大震災による家屋損壊程度と過敏性腸症候群の関連

    永家聖, 中谷直樹, 田中由佳里, 金澤素, 荻島創一, 高井貴子, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 栗山進一, 田中博, 辻一郎, 呉繁夫, 寳澤篤, 福土審

    日本疫学会学術総会講演集(Web) 29th 149 (WEB ONLY) 2019年1月30日

  51. 配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査

    中谷直樹, 土屋菜歩, 中谷久美, 成田暁, 平田匠, 中村智洋, 小暮真奈, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 122 (WEB ONLY) 2019年1月30日

  52. 非肥満者における肝機能指標の組み合わせと糖尿病の関連

    一迫芙美, 平田匠, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 中谷直樹, 栗山進一, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 151 (WEB ONLY) 2019年1月30日

  53. 夫婦間のメタボリック症候群及び構成因子の共有度:東北メディカル・メガバンク計画―地域住民コホート調査

    土屋菜歩, 橋本航, 中谷直樹, 中村智洋, 平田匠, 成田暁, 小暮真奈, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 154 (WEB ONLY) 2019年1月30日

  54. 自宅近隣環境の組み合わせと肥満との関連―東北メディカル・メガバンク計画地域住民コホート調査―

    小暮真奈, 小暮真奈, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 村上慶子, 永井雅人, 栗山進一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 87 (WEB ONLY) 2019年1月30日

  55. 遺伝因子と飲酒量の交互作用と随時血圧値の関連―東北メディカル・メガバンク計画地域住民コホート調査―

    成田暁, 中谷直樹, 小暮真奈, 田宮元, 中村智洋, 土屋菜歩, 平田匠, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 29th 147 (WEB ONLY) 2019年1月30日

  56. 東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

    片柳光昭, 富田博秋, 富田博秋, 瀬戸萌, 瀬戸萌, 根本晴美, 奥山純子, 鈴木智美, 鈴木智美, 菅原由美, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 小高晃, 辻一郎, 辻一郎, 寳澤篤

    日本精神神経学会総会プログラム・抄録集 115th (2019特別号) S.753-S753 2019年

    出版者・発行元:(公社)日本精神神経学会

    ISSN:0033-2658

  57. 尿中ナトリウムカリウム比値と家庭血圧値の変化:地域住民コホート調査

    小暮真奈, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 77th 215-215 2018年10月9日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  58. 東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

    土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫, 大塚耕太郎, 富田博秋, 寳澤篤

    日本公衆衛生学会総会抄録集 77th 252 2018年10月9日

    ISSN:1347-8060

  59. 東日本大震災の被災地住民における家庭血圧値の変化:地域住民コホート調査

    中村智洋, 中谷直樹, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 77th 218-218 2018年10月9日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  60. 東日本大震災の被災地住民における平均歩数の変化:地域住民コホート調査

    中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 77th 209-209 2018年10月9日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  61. 家屋損壊程度と骨梁面積率の変化量の関連:東北メディカル・メガバンク事業

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 77th 253-253 2018年10月9日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  62. 家屋の損壊の程度と頸動脈エコー内膜中膜肥厚の変化 地域住民コホート調査

    寳澤 篤, 中谷 久美, 平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 呉 繁夫

    日本公衆衛生学会総会抄録集 77回 345-345 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  63. 一般住民における尿Na/K比と腎機能障害への進行の関連 住民コホート調査

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 345-345 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  64. 東日本大震災に伴う家屋被害の程度とHbA1c値の変化の関連 地域住民コホート調査

    平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 77回 358-358 2018年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  65. 単日および複数日測定による尿ナトカリ比値と高血圧有病率との関連:東北メディカル・メガバンク計画コホート調査の成果から

    小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 宮川健, 栗山進一, 菅原準一, 菊谷昌浩, 寳澤篤

    日本循環器病予防学会誌 53 (2) 181-181 2018年5月25日

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  66. 東北大学と自治体における尿ナトカリ計の社会実装についての続報

    小暮真奈, 寳澤篤

    宮城県公衆衛生学会会誌 (50) 12‐15 2018年3月

    ISSN:0912-747X

  67. 特定保健指導前後のナトリウムカリウム比変化と家庭血圧値変化との関連:東北大学COI拠点と七ヶ浜町の共同研究

    小暮真奈, 小暮真奈, 宮川健, 宮川健, 板橋由紀, 鈴木智美, 鈴木智美, 土屋菜歩, 中村智洋, 中谷直樹, 青木ゆかり, 阿部真也, 安田純, 安田純, 寳澤篤, 寳澤篤

    宮城県公衆衛生学会会誌 (50) 20-20 2018年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  68. サンプル間の非独立性が関連解析に及ぼす影響の予備的検討

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 田宮元, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 134 (WEB ONLY) 2018年2月1日

  69. 東日本大震災後の夫婦における生活習慣の共有度についての検討

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 77 (WEB ONLY) 2018年2月1日

  70. 自宅周辺の環境とBMI高値との関連―東北メディカル・メガバンク計画地域住民コホート調査―

    小暮真奈, 中谷直樹, 土屋菜歩, 中村智洋, 成田暁, 永井雅人, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 77 (WEB ONLY) 2018年2月1日

  71. 日本茶摂取頻度と頸動脈内膜中膜肥厚の関連

    寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 木皿楓子, 丹野高三, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

    日本疫学会学術総会講演集(Web) 28th 116 (WEB ONLY) 2018年2月1日

  72. 東日本大震災の被災者における高い平均歩数と関連する要因:地域住民コホート調査

    中谷直樹, 成田暁, 土屋菜歩, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌弘, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 137 (WEB ONLY) 2018年2月1日

  73. 周辺環境へのアクセシビリティと産後6ヶ月時点の抑うつ症状との関連:三世代コホート調査

    永井雅人, 水野聖士, 小暮真奈, 石黒真美, 山中千鶴, 松原博子, 小原拓, 小原拓, 菊谷昌浩, 目時弘仁, 目時弘仁, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web) 28th 85 (WEB ONLY) 2018年2月1日

  74. 出生体重と成人期の高血圧有病との関連:東北メディカル・メガバンク計画地域住民コホート調査

    石黒真美, 小原拓, 目時弘仁, 目時弘仁, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

    日本疫学会学術総会講演集(Web) 28th 118 (WEB ONLY) 2018年2月1日

  75. 東日本大震災による家屋損壊の程度とメタボリック症候群の構成要素

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 28th 137 (WEB ONLY) 2018年2月1日

  76. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 国民健康保険受給者における健診受診の関連要因―NIPPON DATA2010横断解析―

    今村晴彦, 小暮真奈, 喜多義邦, 中川秀昭, 寳澤篤, 岡村智教, 村上義孝, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web) 87‐88 (WEB ONLY) 2018年

  77. 東日本大震災における軽度身体的外傷と心理的苦痛の関連:七ヶ浜健康増進プロジェクト 査読有り

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生雑誌 65 (4) 157-163 2018年

    出版者・発行元:日本公衆衛生学会

    DOI: 10.11236/jph.65.4_157  

    ISSN:0546-1766

    詳細を見る 詳細を閉じる

    <p><b>目的</b> 自然災害による身体的外傷がメンタルヘルスに与える影響に関する研究はこれまでにも報告されているが,軽度の身体的外傷においてもメンタルヘルスと関連するかはほとんど検証されていない。本研究は,東日本大震災に起因する軽度身体的外傷と心理的苦痛の関連を横断研究デザインにて検討することを目的とした。</p><p><b>方法</b> 宮城県七ヶ浜町と東北大学は,共同事業「七ヶ浜健康増進プロジェクト」において,東日本大震災後の町民の健康状態や生活状況を把握するための調査を実施している。本研究では,七ヶ浜健康増進プロジェクトが大震災から約1年後に行った調査に参加し,大震災に起因する外傷およびKessler 6項目心理的苦痛尺度(以下,K6)の全設問に回答した対象者のうち,20歳以上の男女3,844人(男性1,821人/女性2,023人)を解析対象とした。心理的苦痛(K6で24点満点中13点以上を「あり」,12点以下を「なし」と定義)を目的変数,身体的外傷の有無を説明変数とし,性,年齢,社会的要因,生活習慣を調整した多変量ロジスティック回帰分析を行った。軽度身体的外傷と心理的苦痛の関連について,震災被害(近親者の喪失,人の死の目撃,家屋損壊程度)のそれぞれで層別化した解析も併せて実施した。</p><p><b>結果</b> 身体的外傷なしの群に対し,ありの群における心理的苦痛の多変量調整済みオッズ比は2.05(1.26-3.34)と有意な正の関連を示した。また,軽度身体的外傷(「擦り傷」,「切り傷・刺し傷」,「打撲・捻挫」)なしの群に対し,ありの群における心理的苦痛の多変量調整済みオッズ比は2.18(1.32-3.59)と有意な正の関連を示した。家屋損壊程度に基づく層別化解析において,家屋が半壊以下であった群では4.01(2.03-7.93)と有意な関連を示したが,大規模半壊以上の群では両者の関連は有意でなく,家屋損壊程度と軽度身体的外傷の間に有意な交互作用が示された(<i>P</i> for interaction=0.03)。</p><p><b>結論</b> 東日本大震災の甚大な被害を受けた地域住民約4,000人を対象に,大震災に起因する身体的外傷と心理的苦痛の関連を検討した。その結果,大震災に起因する軽度身体的外傷と心理的苦痛の間に有意な正の関連が認められた。心理的苦痛のハイリスク者を同定する上で,軽度身体外傷を有する者についても考慮する必要がある。</p>

  78. 東日本大震災後の地域住民における腎機能と関連因子

    土屋菜歩, 清元秀泰, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 菊谷昌浩, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 76th 290-290 2017年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  79. 東日本大震災被災地における運動習慣の状況:TMM CommCohort Study

    高梨信之, 丹野高三, 丹野高三, 佐々木亮平, 佐々木亮平, 坪田恵, 坂田清美, 坂田清美, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 栗山進一, 辻一郎, 中村元行, 人見次郎

    日本公衆衛生学会総会抄録集 76th 603 2017年10月15日

    ISSN:1347-8060

  80. 東日本大震災被災地における社会的孤立の状況:TMM CommCohort Study

    佐々木亮平, 丹野高三, 高梨信之, 坪田(宇津木, 恵, 坂田清美, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 栗山進一, 辻一郎, 中村元行, 人見次郎

    日本公衆衛生学会総会抄録集 76th 603 2017年10月15日

    ISSN:1347-8060

  81. 東日本大震災による家屋の被災状況と骨密度の関連:東北メディカル・メガバンク事業

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寶澤篤

    日本公衆衛生学会総会抄録集 76th 409-409 2017年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  82. 東北メディカル・メガバンク計画地域住民コホート調査における参加者の筋力について

    永井雅人, 土屋菜歩, 菊谷昌浩, 中谷直樹, 成田暁, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菅原準一, 辻一郎, 呉繁夫, 栗山進一, 寳澤篤

    日本公衆衛生学会総会抄録集 76th 652-652 2017年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  83. 性・年齢階級別にみた家族との同居状況と心理的苦痛の関連:地域住民コホート調査

    及川真紀, 及川真紀, 佐藤喜根子, 佐藤眞理, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 富田博秋, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 76th 315-315 2017年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  84. 東日本大震災後の家屋損壊程度と体脂肪率の関連:地域住民コホート調査

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 76th 292-292 2017年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  85. 地域住民コホート調査における家屋の被害の程度と平均歩数の関連

    中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寶澤篤

    日本公衆衛生学会総会抄録集 76th 325-325 2017年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  86. 東北メディカル・メガバンク計画地域住民コホート調査における参加者のAQについて

    山中千鶴, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菊谷昌浩, 石黒真美, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

    日本公衆衛生学会総会抄録集 76th 285-285 2017年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  87. 東北メディカル・メガバンク計画における地域住民コホート調査の詳細二次調査の概要

    寳澤 篤, 丹野 高三, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 菊谷 昌浩, 目時 弘仁, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 中村 元行, 呉 繁夫

    日本公衆衛生学会総会抄録集 76回 287-287 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  88. 尿中ナトリウムカリウム比と高血圧有病リスクとの関連 地域住民コホート調査

    小暮 真奈, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 清元 秀泰, 菊谷 昌浩, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 291-291 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  89. 地域住民コホート調査における年齢別の中心血圧分布

    菊谷 昌浩, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 293-293 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  90. 頸動脈IMTとリスク因子の関連 東北メディカル・メガバンク計画地域住民コホート調査

    木皿 楓子, 土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 高井 貴子, 菊谷 昌浩, 目時 弘仁, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集 76回 293-293 2017年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  91. 飲酒量と推定食塩摂取量との関連:東北メディカル・メガバンク計画地域住民コホート調査

    小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 坪田(宇津木, 恵, 丹野高三, 寳澤篤

    日本アルコール・薬物医学会雑誌 52 (4) 204 2017年8月

    ISSN:1341-8963

  92. 性・年齢別に見た東日本大震災後の地域住民における腎機能と頸動脈内膜中膜複合体厚の関連

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 丹野高三, 菅原準一, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    東北公衆衛生学会講演集 66th (66) 30-30 2017年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  93. 尿ナトカリ計を特定健康診査・特定保健指導に活用した自治体の新たな試み

    小暮真奈, 小暮真奈, 宮川健, 宮川健, 土屋菜歩, 土屋菜歩, 中村智洋, 中村智洋, 中谷直樹, 中谷直樹, 安田純, 安田純, 寳澤篤, 寳澤篤

    東北公衆衛生学会講演集 66th 21 2017年7月

    ISSN:0915-549X

  94. 性・年齢階級別にみた東日本大震災後の平均歩数:地域住民コホート調査

    中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    東北公衆衛生学会講演集 66th (66) 29-29 2017年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  95. カリウム摂取強化の食事指導による尿中ナトカリ比を指標とした減塩効果の介入―第27回日本循環器病予防セミナー研究助成報告―

    桑原和代, 小暮真奈, 中村孝裕, 栗田修司, 小佐見光樹, 内田和彦, 村上優子, 野村加代子, 荒巻真理, 岡村智教

    日本循環器病予防学会誌 52 (2) 188-188 2017年5月29日

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  96. 東北メディカル・メガバンク事業 地域住民コホート(宮城県)の進捗とこれまでの成果で見えてきたこと

    寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 菊谷 昌浩, 小原 拓, 石黒 真美, 佐藤 ゆき, 山中 千鶴, 宮下 真子, 目時 弘仁, 栗山 進一, 辻 一郎

    宮城県公衆衛生学会会誌 (49) 17-17 2017年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  97. 自宅から最寄駅までの距離とBody Mass Indexの関連―震災後の住居による層別化解析

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 辻一郎, 辻一郎, 寳澤篤

    宮城県公衆衛生学会会誌 (49) 18-18 2017年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  98. 国民健康保険受給者における健診受診の関連要因―NIPPON DATA2010横断解析―

    今村晴彦, 小暮真奈, 喜多義邦, 中川秀昭, 寳澤篤, 岡村智教, 村上義孝, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web) 27th 94 (WEB ONLY) 2017年1月25日

  99. 東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較

    中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 100 (WEB ONLY) 2017年1月25日

  100. 東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 103 (WEB ONLY) 2017年1月25日

  101. 東日本大震災後における自宅から最寄駅までの距離とBMIの関連は食事パターンで説明できるか

    小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 88 (WEB ONLY) 2017年1月25日

  102. 東北メディカル・メガバンク事業―地域住民コホート調査の進捗―

    寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 鈴木洋一, 佐藤衛, 峯岸直子, 栗山進一, 辻一郎, 中村元行, 呉繁夫

    日本疫学会学術総会講演集(Web) 27th 113 (WEB ONLY) 2017年1月25日

  103. 東日本大震災後の内陸部と沿岸部の胃がんリスク比較

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫

    日本疫学会学術総会講演集(Web) 27th 130 (WEB ONLY) 2017年1月25日

  104. 東日本大震災後のメンタルヘルスの内陸‐沿岸較差:東北メディカル・メガバンク事業

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 冨田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web) 27th 126 (WEB ONLY) 2017年1月25日

  105. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 国民健康保険受給者における健診受診の関連要因―NIPPON DATA2010横断解析―

    今村晴彦, 小暮真奈, 喜多義邦, 中川秀昭, 寳澤篤, 岡村智教, 村上義孝, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web) 70‐72 (WEB ONLY) 2017年

  106. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 飲酒と高血圧との関連はフラッシング反応により修飾されるか:NIPPON DATA2010

    小暮真奈, 土屋菜歩, 寳澤篤, 中谷直樹, 中村智洋, 宮松直美, 田中英夫, 若林一郎, 東山綾, 奥田奈賀子, 高嶋直敬, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web) 49‐50 (WEB ONLY) 2017年

  107. 職域におけるナトカリ計を用いた効果的な保健指導手法の開発

    桑原和代, 小暮真奈, 岡村智教

    立石科学技術振興財団助成研究成果集(Web) (26) ROMBUNNO.JOSEIKENKYUSEIKAHOKOKU,18 (WEB ONLY) 2017年

  108. 東日本大震災後の自宅から最寄駅までの距離と高血圧治療中断に関する地理疫学的検討

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 75th 253-253 2016年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  109. 東日本大震災における外傷と心理的苦痛の関連:七ヶ浜健康増進プロジェクト

    成田暁, 成田暁, 中谷直樹, 中谷直樹, 中村智洋, 中村智洋, 土屋菜歩, 土屋菜歩, 小暮真奈, 辻一郎, 辻一郎, 寳澤篤, 寳澤篤, 富田博秋, 富田博秋, 富田博秋

    日本公衆衛生学会総会抄録集 75th 208 2016年10月15日

    ISSN:1347-8060

  110. 東日本大震災後の身体活動量とこころの健康の関連:地域住民コホート調査

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 75th 288-288 2016年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  111. 沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク

    中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本公衆衛生学会総会抄録集 75th 303-303 2016年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  112. 東北メディカル・メガバンク事業:地域住民コホート調査の進捗について

    寳澤篤, 丹野高三, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 佐々木亮平, 高梨信之, 坂田清美, 菅原準一, 栗山進一, 中村元行, 呉繁夫, 辻一郎

    日本公衆衛生学会総会抄録集 75th 381-381 2016年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  113. 東日本大震災後の現在の居住地と食事パターンの関連:地域住民コホート調査

    小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

    日本公衆衛生学会総会抄録集 75th 304-304 2016年10月15日

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  114. カリウム摂取強化の食事指導による尿中ナトカリ比を指標とした減塩効果の介入―第27回日本循環器病予防セミナー研究助成 初年度報告―

    桑原和代, 栗田修司, 栗田修司, 小暮真奈, 小佐見光樹, 中村孝裕, 大西浩文, 岡村智教, 岡山明

    日本循環器病予防学会誌 51 (2) 141-141 2016年5月26日

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  115. 東日本大震災後の宮城県沿岸部における治療中断 東北メディカル・メガバンク事業:地域住民コホート調査

    中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 中谷純, 峯岸直子, 布施昇男, 鈴木洋一, 菅原準一, 菊谷昌浩, 富田博秋, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤, 丹野高三, 佐々木亮平, 坂田清美

    宮城県公衆衛生学会会誌 (48) 11-11 2016年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  116. 随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

    寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

    Journal of Epidemiology (Web) 26 (Supplement 1) 123 2016年1月21日

    ISSN:0917-5040

  117. カルシウム摂取量と日常生活動作(ADL)との関連:NIPPON DATA90

    小暮真奈, 土屋菜歩, 成田暁, 寳澤篤, 早川岳人, 奥田奈賀子, 宮川尚子, 三浦克之, 三浦克之, 岡山明, 岡村智教, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web) 26 (Supplement 1) 76 2016年1月21日

    ISSN:0917-5040

  118. 随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

    寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

    Journal of Epidemiology (Web) 26 (Supplement 1) 123 2016年1月21日

    ISSN:1349-9092

  119. カルシウム摂取量と日常生活動作(ADL)との関連:NIPPON DATA90

    小暮真奈, 土屋菜歩, 成田暁, 寳澤篤, 早川岳人, 奥田奈賀子, 宮川尚子, 三浦克之, 三浦克之, 岡山明, 岡村智教, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web) 26 (Supplement 1) 76 2016年1月21日

    ISSN:1349-9092

  120. 宮城県地域住民における心理的苦痛と喫煙行動の関連についての検討

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

    日本公衆衛生学会総会抄録集 74th 296 2015年10月15日

    ISSN:1347-8060

  121. 東日本大震災後の宮城県における歯科受診状況と関連因子についての検討

    土屋 菜歩, 坪井 明人, 白石 成, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 鈴木 洋一, 菊谷 昌浩, 富田 博秋, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤

    日本公衆衛生学会総会抄録集 74回 261-261 2015年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  122. 高齢者におけるイソフラボン摂取が脳容量・認知機能に及ぼす影響

    辻一郎, 遠又靖丈, THYREAU Benjamin, 瀧靖之, 瀧靖之, 渡邉崇, 杉山賢明, 小暮真奈, CHOU Wan‐Ting, 本蔵賢治, 海法悠, 松尾兼幸, 菅原由美, 曽根稔雅, 曽根稔雅, 高橋英子, 柿崎真沙子, 相田潤

    大豆たん白質研究 17 90-94 2015年6月

    ISSN:1344-4050

  123. カリウム摂取強化の食事指導による尿中ナトカリ比を指標とした減塩効果の研究(Na‐K Study)

    桑原和代, 栗田修司, 小暮真奈, 小佐見光樹, 中村孝裕

    日本循環器病予防学会誌 50 (2) 115-115 2015年6月1日

    出版者・発行元:(一社)日本循環器病予防学会

    DOI: 10.24561/00015981  

    ISSN:1346-6267

  124. 東北メディカル・メガバンク 地域住民コホート宮城エリアにおける随時尿Na/K比の内陸部・沿岸部比較

    寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 中谷純, 峯岸直子, 清元秀泰, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

    日本循環器病予防学会誌 50 (2) 126-126 2015年6月1日

    出版者・発行元:(一社)日本循環器病予防学会

    ISSN:1346-6267

  125. 宮城県における東日本大震災被災者の健康状態等に関する調査 被災者に対する運動訓練の効果評価 石巻市雄勝地区におけるハイリスクアプローチ型運動介入の心理的ストレス軽減・生活不活発予防の効果に関する研究

    永富良一, 遠又靖丈, 菅原由美, 杉山賢明, 渡邉崇, 本藏賢治, 海法悠, 小暮真奈

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成26年度総括・分担研究報告書 67-72 2015年

  126. 東日本大震災の被災高齢者における転居先の住宅と運動機能低下に関する前向き研究

    伊藤 久美子, 遠又 靖丈, 小暮 真奈, 菅原 由美, 渡邉 崇, 柿崎 真沙子, 辻 一郎

    日本公衆衛生学会総会抄録集 73回 536-536 2014年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  127. 非常食対応マニュアルと給食提供の早期再開との関連―東日本大震災後における仙台市認可保育所の調査―

    小暮真奈, 遠又靖丈, CHOU Wan‐Ting, 佐々木公子, 佐藤佳子, 青柳友美, 辻一郎

    栄養学雑誌 72 (2) 84-90 2014年4月1日

    DOI: 10.5264/eiyogakuzashi.72.84  

    ISSN:0021-5147

  128. 介護予防事業(二次予防事業)の利用率と新規要介護認定率との関連:保険者間の比較研究

    遠又靖丈, 小暮真奈, 渡邉崇, 杉山賢明, 海法悠, 本蔵賢治, 菅原由美, 柿崎真沙子, 辻一郎

    Journal of Epidemiology 24 (Supplement 1) 63 2014年1月23日

    ISSN:0917-5040

  129. アディポネクチンと尿失禁に関する前向きコホート研究:鶴ケ谷プロジェクト

    本藏賢治, 遠又靖丈, 渡邉崇, CHOU Wan‐Ting, 小暮真奈, 杉山賢明, 松尾兼幸, 高橋英子, 海法悠, 菅原由美, 柿崎真沙子, 辻一郎

    Journal of Epidemiology 24 (Supplement 1) 121 2014年1月23日

    ISSN:0917-5040

  130. 宮城県における東日本大震災被災者の健康状態等に関する調査 被災者健康調査の実施概要

    辻一郎, 菅原由美, 遠又靖丈, 柿崎真沙子, 福地成, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 海法悠, 小暮真奈, 伊藤久美子, 押谷仁, 神垣太郎, 三村敬司, 松岡洋夫, 松本和紀, 富田博秋, 八重樫伸生, 永富良一, 須藤彰子, 井樋栄二, 萩原嘉廣, 南優子, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成25年度総括研究年度終了報告書 11-18 2014年

  131. 宮城県における東日本大震災被災者の健康状態等に関する調査 生活環境の推移とその影響に関する検討

    押谷仁, 辻一郎, 遠又靖丈, 菅原由美, 柿崎真沙子, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 神垣太郎, 三村敬司

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成25年度総括研究年度終了報告書 19-31 2014年

  132. 宮城県における東日本大震災被災者の健康状態等に関する調査 被災者に対する運動訓練の効果評価 石巻地区におけるポピュレーションアプローチ型運動介入の心理的ストレス軽減・生活不活発予防の効果に関する研究

    永富良一, 遠又靖丈, 辻一郎, 菅原由美, 柿崎真沙子, 小暮真奈, 伊藤久美子, 須藤彰子, 金村政輝, 鈴木玲子

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成25年度総括研究年度終了報告書 79-89 2014年

  133. 宮城県における東日本大震災被災者の健康状態等に関する調査 母子保健の影響に関する検討

    八重樫伸生, 辻一郎, 菅原由美, 遠又靖丈, 柿崎真沙子, 福地成, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 海法悠, 小暮真奈

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成25年度総括研究年度終了報告書 41-78 2014年

  134. 宮城県における東日本大震災被災者の健康状態等に関する調査 被災者のメンタルヘルス支援と効果評価―東日本大震災被災者のメンタルヘルスの推移―

    松岡洋夫, 菅原由美, 辻一郎, 遠又靖丈, 柿崎真沙子, 福地成, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 海法悠, 小暮真奈, 富田博秋, 松本和紀, 粟田主一

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成25年度総括研究年度終了報告書 32-40 2014年

  135. 東日本大震災後の仙台市認可保育所における給食提供の実態―フェーズ1からの推移―

    小暮真奈, 佐々木公子, 佐藤佳子, 青柳友美, CHOU Wan‐Ting, 遠又靖丈, 辻一郎

    栄養学雑誌 71 (6) 357-366 2013年12月1日

    出版者・発行元:日本栄養改善学会 ; 1941-

    DOI: 10.5264/eiyogakuzashi.71.357  

    ISSN:0021-5147

  136. 震災後の睡眠状況の変化に関連する要因 被災者健康調査の結果から

    菅原 由美, 柿崎 真沙子, 遠又 靖丈, 渡邉 崇, 小暮 真奈, 辻 一郎

    日本公衆衛生学会総会抄録集 72回 262-262 2013年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  137. 高齢者における生活習慣調査 鶴ヶ谷プロジェクト10年後調査ベースライン調査報告

    柿崎 真沙子, 遠又 靖丈, 菅原 由美, 渡邉 崇, 杉山 賢明, 小暮 真奈, 曽根 稔雅, 海法 悠, 高橋 英子, 辻 一郎

    日本公衆衛生学会総会抄録集 72回 416-416 2013年10月

    出版者・発行元:日本公衆衛生学会

    ISSN:1347-8060

  138. 東日本大震災後の給食施設におけるエネルギー提供量の実態:仙台市認可保育所の調査

    小暮真奈, 佐々木公子, 遠又靖丈, 佐藤佳子, 青柳友美, 辻一郎

    栄養学雑誌 71 (5 Supplement) 331 2013年9月12日

    ISSN:0021-5147

  139. 東日本大震災の被災地における運動教室の効果

    遠又 靖丈, 佐藤 紀子, 小暮 真奈, 須藤 彰子, 渡邉 崇, 杉山 賢明, 菅原 由美, 柿崎 真沙子, 鈴木 玲子, 永富 良一, 辻 一郎

    東北公衆衛生学会誌 62nd (62) 37-37 2013年7月

    出版者・発行元:東北公衆衛生学会

    ISSN:0915-549X

  140. 東日本大震災後の仙台市における保育所給食の実態(第1報)

    遠又 靖丈, 佐々木 公子, 周 婉てい, 佐藤 佳子, 青柳 友美, 伊藤 貴恵, 阿部 鮎美, 大瀧 仁美, 山中 美佳, 小暮 真奈, 柿崎 真沙子, 辻 一郎

    宮城県公衆衛生学会会誌 (45) 9-9 2013年3月

    出版者・発行元:宮城県公衆衛生学会

    ISSN:0912-747X

  141. 東日本大震災後における非常食対応マニュアルと給食提供の早期再開との関連:仙台市保育所の悉皆調査

    小暮真奈, 遠又靖丈, 周婉てい, 佐々木公子, 佐藤佳子, 青柳友美, 伊藤貴恵, 阿部鮎美, 大瀧仁美, 山中美佳, 柿崎真沙子, 辻一郎

    Journal of Epidemiology 23 (Supplement 1) 144 2013年1月24日

    ISSN:0917-5040

  142. 宮城県における東日本大震災被災者の健康状態等に関する調査 被災者健康調査の実施概要

    辻一郎, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 平野かよ子, 神垣太郎, 三村敬司, 松岡洋夫, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健, 富田博秋, 松本和紀, 金村政輝, 相田潤, 粟田主一

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成24年度総括・分担研究報告書 13-22 2013年

  143. 宮城県における東日本大震災被災者の健康状態等に関する調査 被災地高齢者の生活機能の推移:石巻市雄勝地区・牡鹿地区の実態

    辻一郎, 遠又靖丈, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 平野かよ子, 松岡洋夫, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健, 粟田主一

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成24年度総括・分担研究報告書 96-102 2013年

  144. 宮城県における東日本大震災被災者の健康状態等に関する調査 母子保健の影響に関する検討

    八重樫伸生, 辻一郎, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 平野かよ子, 松岡洋夫, 永富良一, 南優子, 佐々木啓一, 小坂健

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成24年度総括・分担研究報告書 48-85 2013年

  145. 宮城県における東日本大震災被災者の健康状態等に関する調査 生活環境の推移とその影響に関する検討

    押谷仁, 辻一郎, 神垣太郎, 三村敬司, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 平野かよ子, 松岡洋夫, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成24年度総括・分担研究報告書 23-31 2013年

  146. 宮城県における東日本大震災被災者の健康状態等に関する調査 被災者の生活習慣の変化とその影響に関する検討

    平野かよ子, 菅原由美, 辻一郎, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成24年度総括・分担研究報告書 32-38 2013年

  147. 介護予防事業の進捗管理と効果評価のためのデータ整備に関する研究 介護予防に資する生活習慣・生活行動に関する研究:鶴ケ谷10年後調査

    辻一郎, 小坂健, 相田潤, 瀧靖之, 中川晴夫, 柿崎真沙子, 遠又靖丈, 菅原由美, 周婉てい, 渡邉崇, 杉山賢明, 本藏賢治, 小暮真奈

    介護予防事業の進捗管理と効果評価のためのデータ整備に関する研究 平成24年度総括・分担研究報告書 35-57 2013年

  148. 宮城県における東日本大震災被災者の健康状態等に関する調査 東日本大震災被災地域における運動教室型保健サービスの概要

    永富良一, 佐藤紀子, 遠又靖丈, 小暮真奈, 青木眸, 今井雪輝

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成24年度総括・分担研究報告書 86-92 2013年

  149. 宮城県における東日本大震災被災者の健康状態等に関する調査 東日本大震災被災者のメンタルヘルスの推移

    松岡洋夫, 柿崎真沙子, 辻一郎, 中原篤史, 佐藤紀子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 平野かよ子, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健, 富田博秋, 松本和紀, 粟田主一

    宮城県における東日本大震災被災者の健康状態等に関する調査 平成24年度総括・分担研究報告書 39-47 2013年

  150. 東日本大震災後にエネルギーの充足された給食を提供できた保育所の特性:関連要因の検証

    遠又靖丈, 佐々木公子, 佐藤佳子, 青柳友美, 伊藤貴恵, 阿部鮎美, 大瀧仁美, 山中美佳, 小暮真奈, 辻一郎

    栄養学雑誌 70 (5 Supplement) 186 2012年9月12日

    ISSN:0021-5147

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 2

  1. 血圧に対するナトリウムカリウム比感受性者の選別とその保健指導への活用に向けた研究

    小暮 真奈, 寳澤 篤

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    研究種目:Grant-in-Aid for Scientific Research (C)

    研究機関:Tohoku University

    2020年4月 ~ 2023年3月

    詳細を見る 詳細を閉じる

    高血圧の原因として、塩分の過剰摂取が知られている。またカリウム摂取による降圧効果も報告されているが、何れも測定に時間を要し、保健指導の現場での活用が困難であった。しかし、最近開発された尿中ナトリウムとカリウムの比(Na/K比)を評価する尿ナトカリ計により尿Na/K比が簡便かつ即時に測定可能となった。尿Na/K比測定を健診等の現場で活用することで、より分かりやすい高血圧指導が可能になると考えられる。しかし、これまでの知見によりNa/K比を下げても血圧が変化しない集団が存在することから、Na/K比の感受性について知見を深める必要もある。本研究では、東北メディカル・メガバンク計画の地域住民コホート調査のデータを用いてNa/K比の感受性遺伝子を同定することを目的として検討を行っている。 本年度は昨年度に引き続き、Na/K比・血圧・遺伝子に関連する先行研究を調べつつ、ゲノムデータの解析方法について東北メディカル・メガバンク機構のGWASセンター(SNPアレイ解析、GWAS解析を実施するセンター)とディスカッションを開始した。そこで専門の先生方より解析の方向性について助言をいただいたので解析対象者や解析方法について見直し、軌道修正を行った。また、GWAS解析を実施するにあたり、Linuxの使用方法についても習得を開始した。更に、前回作成したデータセットから詳細な情報を追加し、人数を増やしてアップデートを行った。今後GWASセンターのサポートを得ながら解析を進める予定である。

  2. 食事・栄養素が認知指標および脳形態に与える影響の解明-オミックス解析を用いた検討

    小暮 真奈, 瀧 靖之, 寳澤 篤, 小柴 生造

    提供機関:Japan Society for the Promotion of Science

    制度名:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    研究種目:Grant-in-Aid for Scientific Research (C)

    研究機関:Tohoku University

    2017年4月 ~ 2020年3月

    詳細を見る 詳細を閉じる

    どの栄養素が、どのような中間物質(代謝物質)を介して脳形態に影響を及ぼしているのかについて、人での作用機序は明らかになっていないのが現状であるため、本研究では「食事・栄養素と脳形態との関連を検証すると同時に食事・栄養素と脳形態・認知機能との中間にある代謝物質を同定すること」を目的として検討を行っている。食事・栄養素と脳形態との関連を検証し、更に食事・栄養素と脳形態・認知機能との中間にある代謝物質を同定するにあたっては、栄養情報、MRI情報、MMSE(認知機能)の情報が必須となるが、現在、①65歳以上、②MRI撮像済み、③MMSE回答済みの全ての条件に該当し、データ化されている者が一定数に満たないため、引き続きデータを蓄積している状況である。 今年度は先行研究の結果に基づき、曝露要因である食品や栄養素、食事パターンの詳細な検討を行った。本データより食事パターンについて因子分析を用いて検討した結果、日本食パターン、洋食パターン、魚・アルコールパターンの3つのパターンに分類されることが考えられた。また要介護認知症発症リスクに高血圧が関わっている可能性が示唆された学会発表もあったことから、尿中のナトリウムカリウム比(ナトカリ比)も認知症に影響を及ぼす要因の一つであることが考えられた。以上の結果や先行研究の結果をもとに、きのこや緑茶、日本食、ナトカリ比を中心とした食品・栄養素・食事パターンと脳形態(大脳皮質や海馬の萎縮)や認知機能との関連を引き続き検討し、更にオミックス解析結果を加えることにより詳細なメカニズムも併せて検討可能あることが考えられる。